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Journal articles on the topic 'Polylactic-co-glycolic acid'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Liu, Liping, Jing Tan, Baoyuan Li, et al. "Construction of functional pancreatic artificial islet tissue composed of fibroblast-modified polylactic-co-glycolic acid membrane and pancreatic stem cells." Journal of Biomaterials Applications 32, no. 3 (2017): 362–72. http://dx.doi.org/10.1177/0885328217722041.

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Objective To improve the biocompatibility between polylactic- co-glycolic acid membrane and pancreatic stem cells, rat fibroblasts were used to modify the polylactic- co-glycolic acid membrane. Meanwhile, we constructed artificial islet tissue by compound culturing the pancreatic stem cells and the fibroblast-modified polylactic- co-glycolic acid membrane and explored the function of artificial islets in diabetic nude mice. Methods Pancreatic stem cells were cultured on the fibroblast-modified polylactic- co-glycolic acid membrane in dulbecco's modified eagle medium containing activin-A, β-cat

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Yammine, Paolo, Rima Kassab, and Dima Moussa. "Encapsulation of an antifungal agent within biodegradable polymers: composition effect." JOURNAL OF ADVANCES IN CHEMISTRY 12, no. 3 (2016): 4274–79. http://dx.doi.org/10.24297/jac.v12i3.2168.

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Polylactic acid and poly(lactic-co-glycolic acid) are two aliphatic polyesters commonly used in drug delivery systems. Having a hydrophobic nature, they could be used for the encapsulation of hydrophobic drugs such as Amphotericin B. Drug-loaded microspheres were prepared using solvent evaporation by changing the ratio of Polylactic acid to poly(lactic-co-glycolic acid) in the organic mixture. Results showed that higher drug encapsulation and drug loading values were seen for formulations having higher lactide content. This had also influenced the drug release rate which was slower at higher l

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Tazhbayev, Burkeyev, Zhaparova, Zhumagalieva, and Arystanova. "Nanoparticles on the basis of polylactic acid and polylactic-co-glycolic acids loaded with drugs." Bulletin of the Karaganda University. "Chemistry" series 90, no. 2 (2018): 31–39. http://dx.doi.org/10.31489/2018ch2/31-39.

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4

Branton, Alice, Mahendra Kumar Trivedi, Dahryn Trivedi, Gopal Nayak, and Snehasis Jana. "Physicochemical and Thermal Characterization of Biofield Energy Treated Polylactic-co-glycolic acid (PLGA)." Journal of Analytical, Bioanalytical and Separation Techniques 4, no. 1 (2019): 1–6. https://doi.org/10.15436/2476-1869.19.2026.

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Polylactic-co-glycolic acid (PLGA) is a biodegradable copolymer. It has many applications in the pharmaceuticals and biomedical industries, but its degradation and stability is a major concern. The objective of this study was to evaluate the influence of the Trivedi Effect® on the physicochemical and thermal properties of PLGA using modern analytical techniques. The PLGA sample was divided into control and Biofield Energy Treated parts. The control sample did not obtain the Biofield Energy Treatment, whereas the treated PLGA was received the Trivedi Effect®-Consciousness Energy Healing

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Ariyasu, Kazumasa, Atsuhiro Ishii, Taiga Umemoto, and Mitsuhiro Terakawa. "Laser-triggered release of encapsulated molecules from polylactic-co-glycolic acid microcapsules." Journal of Biomedical Optics 21, no. 8 (2016): 085003. http://dx.doi.org/10.1117/1.jbo.21.8.085003.

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6

Safaei, Mohsen, Farnoosh Khaleseh, Saba Ahmadi, et al. "Antibacterial effect of polylactic-co-glycolic acid/selenium nanocomposite against dental biofilm." Polimery 70, no. 3 (2025): 186–93. https://doi.org/10.14314/polimery.2025.3.4.

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To determine the optimal conditions for obtaining poly(lactic-co-glycolic) acid with selenium (PLGA/selenium) nanocomposites the Taguchi method was used. FT-IR, Raman spectroscopy, XRD and FESEM analysis confirmed the nanocomposites’ structure. The nanocomposite containing 6 mg/mL of selenium obtained in the process where the mixing time was 75 min showed the highest antibacterial activity against Streptococcus mutans. The obtained nanocomposites are an innovative approach to improving oral health and can be used as antibacterial materials for medical and dental applications.

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Pradhan, Roshan, Bijay Kumar Poudel, Thiruganesh Ramasamy, Han-Gon Choi, Chul Soon Yong, and Jong Oh Kim. "Docetaxel-Loaded Polylactic Acid-Co-Glycolic Acid Nanoparticles: Formulation, Physicochemical Characterization and Cytotoxicity Studies." Journal of Nanoscience and Nanotechnology 13, no. 8 (2013): 5948–56. http://dx.doi.org/10.1166/jnn.2013.7735.

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Kaval, Berna, Fatma Dilara Şen, Kemal Kaya Batmaz, Meliha Ekinci, and A. Alper Öztürk. "Latest research about active pharmaceutical ingredient loaded Poly Lactic Acid-co-Glycolic Acid (PLGA) based drug delivery system in Türkiye." European Journal of Life Sciences 1, no. 3 (2023): 127–39. http://dx.doi.org/10.55971/ejls.1197082.

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Some of the most well-engineered and produced biomaterials are polyesters based on polyglycolic acid (PGA), polylactic acid (PLA), and their copolymers, polylactic acid co-glycolic acid (PLGA). In controlled release systems, PLGA is the most extensively used and popular polymer. Because of its biodegradability, biocompatibility, and favorable release kinetics, but also because of the reliability of protein delivery issues, this synthetic polymer has been found to be very successful. PLGA is approved in various human drug delivery systems by EMA and FDA. In this review, first, PLGA and historic

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Contreras-Magallanes, Yesenia Guadalupe, Marina Durán-Aguilar, Susana L. Sosa-Gallegos, et al. "Prime Vaccination with Chitosan-Coated Phipps BCG and Boosting with CFP-PLGA against Tuberculosis in a Goat Model." Animals 11, no. 4 (2021): 1046. http://dx.doi.org/10.3390/ani11041046.

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Attempts to improve the immune response and efficacy of vaccines against tuberculosis in cattle, goats, and other animal species have been the focus of research in this field during the last two decades. Improving the vaccine efficacy is essential prior to running long-lasting and expensive field trials. Studies have shown that vaccine protocols utilizing boosting with proteins improve the vaccine efficacy. The use of polymers such as chitosan and PolyLactic-co-Glycolic Acid (PLGA) improves the immune response against different diseases by improving the interaction of antigens with the cellula

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10

Jiang, Jun, Jianpeng Xiao, Dongqing Wang, and Huazhong Cai. "Application of Implantable Polylactic-Co-Glycolic Acid Microcapsule in Repairing Alveolar Bone Defects." Evidence-Based Complementary and Alternative Medicine 2021 (July 27, 2021): 1–10. http://dx.doi.org/10.1155/2021/5580785.

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Alveolar bone defects (ABDs) were a perennial problem, especially in the aged. Bisphosphonates, especially etidronate sodium (ET), were frequently used in clinical treatment of ABD. However, the oral administration of ET had poor absorption (<1%). Therefore, optimization of a suitable dosage form substituted with ET to locally repair the ABD was a straightforward approach. Polylactide-co-glycolide (PLGA) is a biodegradable material and had been used in locally implanted medical devices. Therefore, an ET-PLGA microcapsule may help local delivery and prolong the activity of healing ABD. In th

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Prakobvaitayakit, Mukdavan, and Ubonthip Nimmannit. "Optimization of polylactic-co-glycolic acid nanoparticles containing itraconazole using 23 factorial design." AAPS PharmSciTech 4, no. 4 (2003): 565–73. http://dx.doi.org/10.1208/pt040471.

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12

Rezaee-Tazangi, Fatemeh, Negar Varaa, Layasadat Khorsandi, and Mohammadreza Abbaspour. "Effects of Silymarin-Loaded Polylactic-co-Glycolic Acid Nanoparticles on Osteoarthritis in Rats." Iranian Journal of Science and Technology, Transactions A: Science 44, no. 3 (2020): 605–14. http://dx.doi.org/10.1007/s40995-020-00870-y.

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13

Daugherty, Ann L., Jeffrey L. Cleland, Eileen M. Duenas, and Randall J. Mrsny. "Pharmacological modulation of the tissue response to implanted polylactic-co-glycolic acid microspheres." European Journal of Pharmaceutics and Biopharmaceutics 44, no. 1 (1997): 89–102. http://dx.doi.org/10.1016/s0939-6411(97)00065-9.

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14

Ghaderinia, Parivash, Reza Shapouri, Kobra Rostamizadeh, Alireza Khodavandi, and Mehdi Mahdavi. "Capsular K-antigen-PLGA Nano conjugated Vaccine against Klebsiella pneumoniea pneumoniae K2O1 Infection." Journal of Advances in Medical and Biomedical Research 30, no. 138 (2021): 73–74. https://doi.org/10.30699/jambs.30.e57891.

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<strong>Abstract:</strong>    <em>Klebsiella pneumoniae</em> is the most common pathogenic bacterium in the genus <em>Klebsiella </em>(1). The aim of this study was to use Polylactic-co-glycolic acid (PLGA) nanoparticles in vaccine design of the capsule antigen of <em>Klebsiella pneumoniae</em> K2O1. The capsular antigen was loaded into the polylactic-co-glycolic acid (PLGA) nanoparticles by W/O /W method (5). FT-IR and AFM were used to confirm capsule antigen loading and morphology of the nanoparticles, respectively (6,7). The fever after the vaccination was

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15

Balaban, Mihaela, Bogdana Virgolici, Adriana Dinu, et al. "Metabolic Parameters in Wistar Rats Treated with Glucocorticosteroids and Vitamin E-Charged Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles." Revista de Chimie 70, no. 4 (2019): 1315–18. http://dx.doi.org/10.37358/rc.19.4.7117.

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Glucocorticosteroids are the mainstay of treatment in many inflammatory and autoimmune disorders. Their administration can be associated with various side effects, similar to those within the metabolic syndrome. The beneficial effects of vitamin E in metabolic syndrome were demonstrated by many studies. Nowadays, vitamin E can be administrated through a new and innovative system delivery, such as polylactic-co-glycolic acid nanoparticles (PLGA-NPs). The aim of this experimental study was to compare the metabolic and haematological parameters after Prednisone administration as a single drug or

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Özcan, Mutlu, Dachamir Hotza, Márcio Celso Fredel, Ariadne Cruz, and Claudia Angela Maziero Volpato. "Materials and Manufacturing Techniques for Polymeric and Ceramic Scaffolds Used in Implant Dentistry." Journal of Composites Science 5, no. 3 (2021): 78. http://dx.doi.org/10.3390/jcs5030078.

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Preventive and regenerative techniques have been suggested to minimize the aesthetic and functional effects caused by intraoral bone defects, enabling the installation of dental implants. Among them, porous three-dimensional structures (scaffolds) composed mainly of bioabsorbable ceramics, such as hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) stand out for reducing the use of autogenous, homogeneous, and xenogenous bone grafts and their unwanted effects. In order to stimulate bone formation, biodegradable polymers such as cellulose, collagen, glycosaminoglycans, polylactic acid (PLA)

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Kim, Sang-Guen, Sib Sankar Giri, Su-Jin Jo, et al. "Prolongation of Fate of Bacteriophages In Vivo by Polylactic-Co-Glycolic-Acid/Alginate-Composite Encapsulation." Antibiotics 11, no. 9 (2022): 1264. http://dx.doi.org/10.3390/antibiotics11091264.

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With concern growing over antibiotics resistance, the use of bacteriophages to combat resistant bacteria has been suggested as an alternative strategy with which to enable the selective control of targeted pathogens. One major challenge that restrains the therapeutic application of bacteriophages as antibacterial agents is their short lifespan, which limits their antibacterial effect in vivo. Here, we developed a polylactic-co-glycolic acid (PLGA)/alginate-composite microsphere for increasing the lifespan of bacteriophages in vivo. The alginate matrix in PLGA microspheres encapsulated the bact

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Mironov, Anton Vladimirovich, Olga Anatolevna Mironova, Maria Aleksandrovna Syachina, and Vladimir Karpovich Popov. "3D printing of polylactic-co-glycolic acid fiber scaffolds using an antisolvent phase separation process." Polymer 182 (November 2019): 121845. http://dx.doi.org/10.1016/j.polymer.2019.121845.

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19

Xue, Min, Qun Zhao, Zhi-yue Li, et al. "Polylactic-co-glycolic acid microspheres containing three neurotrophic factors promote sciatic nerve repair after injury." Neural Regeneration Research 10, no. 9 (2015): 1491. http://dx.doi.org/10.4103/1673-5374.165522.

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20

Algebraistova, Polina Yu, Andrey V. Basko, Anna N. Ilyasova, et al. "Phase Equilibria and Structure Formation in the Polylactic-co-Glycolic Acid/Tetraglycol/Water Ternary System." Polymers 15, no. 5 (2023): 1281. http://dx.doi.org/10.3390/polym15051281.

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This paper concerns a detailed study of the phase separation and structure formation processes that occur in solutions of highly hydrophobic polylactic-co-glycolic acid (PLGA) in highly hydrophilic tetraglycol (TG) upon their contact with aqueous media. In the present work, cloud point methodology, high-speed video recording, differential scanning calorimetry, and both optical and scanning electron microscopy were used to analyze the behavior of PLGA/TG mixtures differing in composition when they are immersed in water (the so-called “harsh” antisolvent) or in a nonsolvent consisting of equal a

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21

Petposri, Sidabhat, Nuttawut Thuaksuban, Supanee Buranadham, Trin Suwanrat, Winita Punyodom, and Woraporn Supphaprasitt. "Physical Characteristics and Biocompatibility of 3D-Printed Polylactic-Co-Glycolic Acid Membranes Used for Guided Bone Regeneration." Journal of Functional Biomaterials 14, no. 5 (2023): 275. http://dx.doi.org/10.3390/jfb14050275.

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Bioresorbable polymeric membranes for guided bone regeneration (GBR) were fabricated using the three-dimensional printing technique. Membranes made of polylactic-co-glycolic acid (PLGA), which consist of lactic acid (LA) and glycolic acid in ratios of 10:90 (group A) and 70:30 (group B), were compared. Their physical characteristics including architecture, surface wettability, mechanical properties, and degradability were compared in vitro, and their biocompatibilities were compared in vitro and in vivo. The results demonstrated that the membranes of group B had mechanical strength and could s

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Christoforidis, John B., Susie Chang, Angela Jiang, Jillian Wang, and Colleen M. Cebulla. "Intravitreal Devices for the Treatment of Vitreous Inflammation." Mediators of Inflammation 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/126463.

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The eye is a well-suited organ for local delivery of therapeutics to treat vitreous inflammation as well as other pathologic conditions that induce visual loss. Several conditions are particularly challenging to treat and often require chronic courses of therapy. The use of implantable intravitreal devices for drug delivery is an emerging field in the treatment of vitreous inflammation as well as other ophthalmologic diseases. There are unique challenges in the design of these devices which include implants, polymers, and micro- and nanoparticles. This paper reviews current and investigational

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23

Casalini, Tommaso, Monica Bassas-Galia, Hervé Girard, et al. "A Systematic Experimental and Computational Analysis of Commercially Available Aliphatic Polyesters." Applied Sciences 9, no. 16 (2019): 3397. http://dx.doi.org/10.3390/app9163397.

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Aliphatic polyesters, such as polylactic acid (PLA), polyglycolic acid (PGA), and their copolymer polylactic-co-glycolic acid (PLGA) have become an established choice in the biomedical field in a wide range of applications, from nanoparticles for local drug delivery to bone fixation screws, and, hence, in a huge spectrum of uses in different medical devices currently available on the market worldwide. The reason for their popularity lies in their combination of interesting peculiarities: in situ degradation, intrinsic biocompatibility (degradation products are recognized and metabolized), proc

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Branton, Alice, Mahendra Kumar Trivedi, Dahryn Trivedi, Gopal Nayak, and Snehasis Jana. "Assessment of the Physicochemical and Thermal Characterization of Biofield Energy Treated Polylactic-co-glycolic acid (PLGA)." Journal of Analytical, Bioanalytical and Separation Techniques 3, no. 1 (2019): 1–6. http://dx.doi.org/10.15436/2476-1869.19.2026.

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Polylactic-co-glycolic acid (PLGA) is a biodegradable copolymer. It has many applications in the pharmaceuticals and biomedical industries, but its degradation and stability is a major concern. The objective of this study was to evaluate the influence of the Trivedi Effect® on the physicochemical and thermal properties of PLGA using modern analytical techniques. The PLGA sample was divided into control and Biofield Energy Treated parts. The control sample did not obtain the Biofield Energy Treatment, whereas the treated PLGA was received the Trivedi Effect®-Consciousness Energy Healing Treatme

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25

Yang, Tianzhi, Divine Nyiawung, Alexandra Silber, Jiukuan Hao, Leanne Lai, and Shuhua Bai. "Comparative Studies on Chitosan and Polylactic-co-glycolic Acid Incorporated Nanoparticles of Low Molecular Weight Heparin." AAPS PharmSciTech 13, no. 4 (2012): 1309–18. http://dx.doi.org/10.1208/s12249-012-9854-8.

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TANG, Hai, Ning XU, Jin MENG, Chao WANG, Shu-fang NIE, and Wei-san PAN. "Application of a Novel Approach to Prepare Biodegradable Polylactic-co-glycolic Acid Microspheres: Surface Liquid Spraying." YAKUGAKU ZASSHI 127, no. 11 (2007): 1851–62. http://dx.doi.org/10.1248/yakushi.127.1851.

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27

Ghosh, Pooja, Jayita Patwari, and Swagata Dasgupta. "Complexation With Human Serum Albumin Facilitates Sustained Release of Morin From Polylactic-Co-Glycolic Acid Nanoparticles." Journal of Physical Chemistry B 121, no. 8 (2017): 1758–70. http://dx.doi.org/10.1021/acs.jpcb.6b08559.

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28

Wu, Jingyao, Xi Lu, Lili Tan, Bingchun Zhang, and Ke Yang. "Effect of hydrion evolution by polylactic-co-glycolic acid coating on degradation rate of pure iron." Journal of Biomedical Materials Research Part B: Applied Biomaterials 101, no. 7 (2013): 1222–32. http://dx.doi.org/10.1002/jbm.b.32934.

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29

Ibarra, Blanca, Joaquin García‐García, Galo Azuara, et al. "Polylactic‐co‐glycolic acid microspheres added to fixative cements and its role on bone infected architecture." Journal of Biomedical Materials Research Part B: Applied Biomaterials 107, no. 8 (2019): 2517–26. http://dx.doi.org/10.1002/jbm.b.34342.

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30

Wang, Yongbo, Bin Yao, Zhenbo Wang, Tianyu Xie, and Jichao Ye. "Development of polylactic-co-glycolic acid-polyethylene glycol nanoparticles as drug carriers to promote wound healing." Materials Express 13, no. 3 (2023): 442–46. http://dx.doi.org/10.1166/mex.2023.2359.

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Impaired wound healing is a common complication of orthopedic surgery and poses a difficult challenge in the clinic. Fibroblasts are thought to play a significant role in wound healing, and can be positively affected by low concentrations of rapamycin; however, rapamycin is cytotoxic at higher concentrations. To address this issue, a RAPA/PLGA-PEG drug delivery system was constructed in this study to maintain low concentrations of rapamycin. The results showed that the nanoparticles were stable, had good sustained drug release properties and were able to reduce the toxicity of rapamycin to fib

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31

González, Arely M., Raúl Rosales, Juan Ludert, et al. "POLYCAPROLACTONE AND POLYLACTIC-CO-GLYCOLIC ACID (80:20) SCAFFOLD APPLICATIONS: EVALUATION FOR HYALINE CARTILAGE TISSUE ENGINEERING." Osteoarthritis and Cartilage 33 (April 2025): S326—S327. https://doi.org/10.1016/j.joca.2025.02.457.

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32

Shanmugam, Kirubanandan. "Modification of Biodegradable Polymer Nanofibers for Cartilage Tissue Engineering Applications: A Review." Bone and Arthrosurgery Science 2, no. 1 (2024): 9–29. http://dx.doi.org/10.26689/bas.v2i1.5957.

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Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physiochemical factors to improve or replace biological functions at the injured site. The designing of a biomaterial that can mimic the three-dimensional tissues in vivo is still challenging. Biodegradable polymers are used for the development of tissue engineering constructs in the form of sponges, films, and macroporous scaffolds, which do not influence cell fate processes such as cell differentiation, migration, and proliferation. Biodegradable polymer nanofibers fabrica

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Farjaminejad, Samira, Rosana Farjaminejad, Melika Hasani, et al. "Advances and Challenges in Polymer-Based Scaffolds for Bone Tissue Engineering: A Path Towards Personalized Regenerative Medicine." Polymers 16, no. 23 (2024): 3303. http://dx.doi.org/10.3390/polym16233303.

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Polymers have become essential in advancing bone tissue engineering, providing adaptable bone healing and regeneration solutions. Their biocompatibility and biodegradability make them ideal candidates for creating scaffolds that mimic the body’s natural extracellular matrix (ECM). However, significant challenges remain, including degradation by-products, insufficient mechanical strength, and suboptimal cellular interactions. This article addresses these challenges by evaluating the performance of polymers like poly(lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL), and polylactic acid (P

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Pavlinich, Sergey, Xi Wei Liu, Hong Zhao, Zhen Li, and Li Li. "Study on Kinetics and Biocompatibility Evaluation of Multiple Polymer Layer with Biochemical Material Properties in Drug-Eluting Stent." Advanced Materials Research 644 (January 2013): 183–88. http://dx.doi.org/10.4028/www.scientific.net/amr.644.183.

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The Paclitaxel-eluting stents (PTX) with three-layered polymer coating were studied in this work. The PLGA (polylactic acid-co-glycolic acid) with 15 percent PEG (poly ethylene glycol) concentration in blend have been applied for preparing multiple layer drug carrier and fabricated on the surface of 316L stainless steel stents by ultrasonic atomization spraying method. The Paclitaxel was explored in doses: (~255μg) for single layer coated PTX (30 wt%), and (~275μg) for multiple layer coated PTX in accordance. Pre- and post-expansion surface morphologies of multiple layer stent were examined by

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Pavlinich, Sergey, Xi Wei Liu, Li Da Hou, Hong Zhao, Zhen Li, and Li Li. "In Vitro Drug Release and Hemocompatibility of Biodegradable Plga/Peg Coated Paclitaxel-Eluting Stents." Advanced Materials Research 651 (January 2013): 49–53. http://dx.doi.org/10.4028/www.scientific.net/amr.651.49.

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The Paclitaxel-eluting stents (PTX) with biodegradable copolymer coating were studied in investigations. The polymer blend composition of PLGA (polylactic acid-co-glycolic acid) and PEG (poly ethylene glycol) have been applied as drug carrier and fabricated on the surface of 316L stainless steel stents by ultrasonic atomization spraying method. Were explored three doses: low-dose (~80μg per stent, 10 wt%), moderate-dose (~150μg per stent , 20 wt%), and high-dose (~220μg per stent , 30 wt%). The weight ratio of Paclitaxel to PLGA/PEG blends was 10:90, 20:80, and 30:70. Pre- and post-expansion s

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Guerrero, Daissy Julieth Paredes, Jhon Jhamilton Artunduaga Bonilla, Claudia Cristina Ortiz López, and Rodrigo Gonzalo Torres Sáez. "Encapsulation of Silver Nanoparticles in Polylactic Acid or Poly(lactic-co-glycolic acid) and Their Antimicrobial and Cytotoxic Activities." Journal of Nanoscience and Nanotechnology 19, no. 11 (2019): 6933–41. http://dx.doi.org/10.1166/jnn.2019.16663.

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Encapsulation with biodegradable polymers is an alternative to reduce adverse effects and improve the physicochemical properties of metallic nanoparticles. In this study, spherical polymeric nanoparticles with an average size of 200 nm loaded with silver nanoparticles (AgNPs) were obtained. The antimicrobial activity against Escherichia coli O157:H7, methicillin-resistant Staphylococcus aureus (MRSA), and yeasts as Candida albicans, Candida parapsilosis and Candida guilliermondii was determined. MIC90 values of nanocomposites were between 0.01 to 1 μg/mL, potentialized effect up to 500 times c

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Nayak, Gopal, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, and Snehasis Jana. "Evaluation of the Physicochemical and Thermal Properties of Consciousness Energy Healing Treated Polylactic-co-glycolic Acid (PLGA)." Journal of Food Science and Technology 5, no. 3 (2018): 117–25. https://doi.org/10.5281/zenodo.3373548.

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Poly(lactic-co-glycolic acid) (PLGA) is an FDA approved popular biodegradable copolymer, which has several applications in the pharmaceuticals and biomedical industries. But the degradation and stability of PLGA is a major problem. The objective of this research work was to evaluate the effect of the Trivedi Effect®-Consciousness Energy Healing Treatment on the physicochemical and thermal properties of PLGA using modern analytical techniques. The test sample was divided into control and treated parts. The control part of the test sample did not receive the Biofield Energy Treatment; wherea

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Casalini, Tommaso, Filippo Rossi, Luisa Brizielli, and Giuseppe Perale. "Theoretical Investigation of Design Space for Multi Layer Drug Eluting Bioresorbable Suture Threads." Current Pharmaceutical Biotechnology 20, no. 4 (2019): 332–45. http://dx.doi.org/10.2174/1389201020666190206200411.

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Background: The work presented here is focused on the development of a comprehensive theoretical model for the description of drug release from a double - layer bioresorbable suture thread and the therapeutic efficacy of the active compounds delivered in the surrounding tissue. Methods: In particular, the system under investigation is composed of a core of slow-degrading polylactic- acid-co-ε-caprolactone (PLCL), where an antibiotic compound (Vancomycin) is loaded, surrounded by a shell of a fast-degrading polylactic-co-glycolic acid (PLGA) which contains an anesthetic drug (Lidocaine hydrochl

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Shahi, Maryam, Mahmood Nadari, Mehdi Sahmani, Ehsan Seyedjafari, Naser Ahmadbeigi, and Amir Peymani. "Osteoconduction of Unrestricted Somatic Stem Cells on an Electrospun Polylactic-Co-Glycolic Acid Scaffold Coated with Nanohydroxyapatite." Cells Tissues Organs 205, no. 1 (2018): 9–19. http://dx.doi.org/10.1159/000485122.

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The limitation of traditional bone grafts could be overcome by applying engineered bone constructs, which are mainly produced by seeding suitable stem cells on appropriate scaffolds. So far, bone marrow-derived stromal cells have been the most applied cells in bone tissue engineering, but current data show that unrestricted somatic stem cells (USSCs) from human cord blood might actually be a better stem cell source due to the accessibility and noninvasive procedure of collection. In this study, we cultured USSCs on a plasma-treated electrospun polylactic-co-glycolic acid (PLGA) scaffold coated

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Mohebbi, Elaheh, Eleonora Pavoni, Cristina Minnelli, et al. "Adsorption of Polylactic-co-Glycolic Acid on Zinc Oxide Systems: A Computational Approach to Describe Surface Phenomena." Nanomaterials 14, no. 8 (2024): 687. http://dx.doi.org/10.3390/nano14080687.

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Zinc oxide and polylactic-co-glycolic acid (ZnO-PLGA) nanocomposites are known to exhibit different biomedical applications and antibacterial activity, which could be beneficial for adding to wound dressings after different surgeries. However, possible cytotoxic effects along with various unexpected activities could reduce the use of these prominent systems. This is correlated to the property of ZnO, which exhibits different polymeric forms, in particular, wurtzite, zinc-blende, and rocksalt. In this study, we propose a computational approach based on the density functional theory to investiga

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Castagna, Arianna, Alexandra J. Zander, Iaroslaw Sautkin, et al. "Enhanced intraperitoneal delivery of charged, aerosolized curcumin nanoparticles by electrostatic precipitation." Nanomedicine 16, no. 2 (2021): 109–20. http://dx.doi.org/10.2217/nnm-2020-0373.

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Aims: To investigate the potential of curcumin-loaded polylactic-co-glycolic acid nanoparticles (CUR-PLGA-NPs), alone and with electrostatic precipitation, for improving tissue uptake during pressurized intraperitoneal aerosol chemotherapy (PIPAC). Methods: Positively and negatively charged CUR-PLGA-NPs were delivered as PIPAC into inverted bovine urinary bladders ex vivo. The experiment was repeated with the additional use of electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (electrostatic PIPAC). Results: Positively charged CUR-PLGA-NPs increased depth of tissue pe

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Zahra, Fatima T., Quincy Quick, and Richard Mu. "Electrospun PVA Fibers for Drug Delivery: A Review." Polymers 15, no. 18 (2023): 3837. http://dx.doi.org/10.3390/polym15183837.

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Innovation in biomedical science is always a field of interest for researchers. Drug delivery, being one of the key areas of biomedical science, has gained considerable significance. The utilization of simple yet effective techniques such as electrospinning has undergone significant development in the field of drug delivery. Various polymers such as PEG (polyethylene glycol), PLGA (Poly(lactic-co-glycolic acid)), PLA(Polylactic acid), and PCA (poly(methacrylate citric acid)) have been utilized to prepare electrospinning-based drug delivery systems (DDSs). Polyvinyl alcohol (PVA) has recently g

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Izquierdo, Natalia, Enrique Gamez, Teresa Alejo, Gracia Mendoza, and Manuel Arruebo. "Antimicrobial Photodynamic Therapy Using Encapsulated Protoporphyrin IX for the Treatment of Bacterial Pathogens." Materials 17, no. 8 (2024): 1717. http://dx.doi.org/10.3390/ma17081717.

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Herein, we report on the antimicrobial photodynamic effect of polymeric nanoparticles containing the endogenous photosensitizer protoporphyrin IX. Compared to equivalent doses of the free photosensitizer, we demonstrated that the photodynamic antimicrobial efficacy of PLGA (polylactic-co-glycolic acid) nanoparticles containing protoporphyrin IX (PpIX) against pathogenic Staphylococcus aureus (S. aureus) is preserved after encapsulation, while photobleaching is reduced. In addition, compared to equivalent doses of the free porphyrin, we show that a reduction in the cytotoxicity in mammalian cel

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Xu, Wen, Qingping Zhang, and Leiming Sun. "Enhancement of the antitumor effect of cisplatin and ginsenoside Rg3 by encapsulation in polylactic-co-glycolic acid nanoparticles." Tropical Journal of Pharmaceutical Research 23, no. 1 (2024): 51–56. http://dx.doi.org/10.4314/tjpr.v23i1.7.

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Purpose: To develop dual-loaded polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) with two chemotherapeutic agents, i.e., cisplatin (DDP) and 20(R)-ginsenoside Rg3(Rg3), and to evaluate the drug release profiles and synergistic inhibitory effects of the nanoparticles on lung cancer A549 cells.Methods: The dual-laden PLGA NPs were synthesized using modified emulsion and solvent vaporization procedures. Drug loading (DL) and efficacy of co-encapsulation (EE) were determined with a modification of column elution technique. The cytotoxic and inhibitory effects of individual and combined drugs

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Islam, Mohammad Saiful, and Somenath Mitra. "Synthesis of Microwave Functionalized, Nanostructured Polylactic Co-Glycolic Acid (nfPLGA) for Incorporation into Hydrophobic Dexamethasone to Enhance Dissolution." Nanomaterials 13, no. 5 (2023): 943. http://dx.doi.org/10.3390/nano13050943.

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The low solubility and slow dissolution of hydrophobic drugs is a major challenge for the pharmaceutical industry. In this paper, we present the synthesis of surface-functionalized poly(lactic-co-glycolic acid) (PLGA) nanoparticles for incorporation into corticosteroid dexamethasone to improve its in vitro dissolution profile. The PLGA crystals were mixed with a strong acid mixture, and their microwave-assisted reaction led to a high degree of oxidation. The resulting nanostructured, functionalized PLGA (nfPLGA), was quite water-dispersible compared to the original PLGA, which was non-dispersi

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Li, Xia, Jiale Zhou, Haiyan Wu, Fangyin Dai, Jiashen Li, and Zhi Li. "Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer." Molecules 27, no. 14 (2022): 4563. http://dx.doi.org/10.3390/molecules27144563.

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Photothermal therapy is a promising treating method for cancers since it is safe and easily controllable. Black phosphorus (BP) nanosheets have drawn tremendous attention as a novel biodegradable thermotherapy material, owing to their excellent biocompatibility and photothermal properties. In this study, silk fibroin (SF) was used to exfoliate BP with long-term stability and good solution-processability. Then, the prepared BP@SF was introduced into fibrous membranes by electrospinning, together with SF and polylactic-co-glycolic acid (PLGA). The SF/PLGA/BP@SF membranes had relatively smooth an

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Wang, Wei, Kun Fang, Xiaobing Wang, et al. "Antigen-Specific Killer Polylactic-Co-Glycolic Acid (PLGA) Microspheres Can Prolong Alloskin Graft Survival in a Murine Model." Immunological Investigations 44, no. 4 (2015): 385–99. http://dx.doi.org/10.3109/08820139.2015.1014098.

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Fu, Shaoju, Dongchao Yang, Peihua Zhang, and Gang Sun. "Antibacterial Polylactic-co-glycolic Acid Braided Threads Using Plasma and Coating Modifications for Acupoint Catgut Embedding Therapy Applications." ACS Applied Bio Materials 3, no. 4 (2020): 1902–12. http://dx.doi.org/10.1021/acsabm.9b01071.

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Chen, Liben, Shuang Li, Zhengfang Wang, Ruilong Chang, Jingliang Su, and Bo Han. "Protective effect of recombinant staphylococcal enterotoxin A entrapped in polylactic-co-glycolic acid microspheres against Staphylococcus aureus infection." Veterinary Research 43, no. 1 (2012): 20. http://dx.doi.org/10.1186/1297-9716-43-20.

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Huang, Jia, Xiaobo Zhou, Yanbing Shen, et al. "Asiaticoside loading into polylactic‐co‐glycolic acid electrospun nanofibers attenuates host inflammatory response and promotes M2 macrophage polarization." Journal of Biomedical Materials Research Part A 108, no. 1 (2019): 69–80. http://dx.doi.org/10.1002/jbm.a.36793.

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