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Dissertations / Theses on the topic 'Polymeric micelles Doxorubicin Drug'

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Published: 2 June 2025

Last updated: 31 July 2025

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1

Teng, Yue. "Solubilization and release studies of small molecules in polymeric micelles /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

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Master, Alyssa M. "EGFR-Targeted Polymeric Micelles For Targeted Pc 4-PDT Of Oropharyngeal Tumors." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1364833269.

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3

Pawlish, Gerald Joseph. "TAILORING DRUG-CARRIER INTERACTIONS IN POLY(SIALIC ACID) MICELLES FOR USE AS CANCER THERAPEUTIC CARRIERS." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/519673.

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Bioengineering<br>Ph.D.<br>Although great progress has been made, cancer still remains one of the most prevalent maladies plaguing mankind. New treatment methodologies using nanoparticles have come to the forefront by allowing for enhanced delivery of therapeutics to the tumor site. The design of the nanoparticle should allow for long circulation times, tumor-specific targeting and efficient release at the site of action. This requires that both the external shell and internal core of the nanoparticle be carefully selected to meet the maximal criteria of each of these steps. Poly(sialic acid)

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Mishra, Kaushik. "Folate Receptor-Targeted Polymeric Micellar Nanocarriers as Drug Delivery Systems." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1629218263972419.

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Hans, Meredith L. Lowman Anthony M. "Synthesis, characterization, and application of biodegradable polymeric prodrug micelles for long-term drug delivery /." Philadelphia, Pa. : Drexel University, 2006. http://dspace.library.drexel.edu/handle/1860/741.

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6

Brunato, Silvia. "Biocompatible modular nanovectors for anticancer drug delivery and controlled release." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3425395.

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The research project of this PhD thesis was focused on the design and development of innovative “smart” nanosystems for a controlled anticancer drug delivery. Smart drug delivery systems have emerged as a strategy to achieve enhanced site-specific drug accumulation and control release within the desired tissue, thus offering the opportunity to reduce systemic side effects caused by an unspecific drug biodistribution. Among the several colloidal systems available, polymeric micelles formed by amphiphilic polyaminoacidic block copolymers are gaining relevance for therapeutic application as the

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Lavrador, Pedro Oliveira. "Development of drug-loaded polymeric nanomicelles for stem cell osteogenic differentiation." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22832.

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Mestrado em Bioquímica Clínica<br>As doenças musculoesqueléticas afetam atualmente uma grande percentagem da população mundial sendo esperado que a sua prevalência venha a aumentar no futuro. De entre as abordagens terapêuticas atualmente aplicadas a nível clínico para as patologias ou danos ósseos, a utilização de terapias celulares baseadas em células estaminais mesenquimais humanas (hMSCs) surge como uma das mais promissoras devido à capacidade de diferenciação das hMSCs em células do tecido esquelético. No entanto, a diferenciação destas células em células osteoprogenitoras tem sido

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8

Diaz, Mario Alfonso. "High-Frequency Ultrasound Drug Delivery and Cavitation." BYU ScholarsArchive, 2007. https://scholarsarchive.byu.edu/etd/1050.

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The viability of a drug delivery system which encapsulates chemotherapeutic drugs (Doxorubicin) in the hydrophobic core of polymeric micelles and triggers release by ultrasound application was investigated at an applied frequency of 500 kHz. The investigation also included elucidating the mechanism of drug release at 70 kHz, a frequency which had previously been shown to induce drug release. A fluorescence detection chamber was used to measure in vitro drug release from both Pluronic and stabilized micelles and a hydrophone was used to monitor bubble activity during the experiments. A threshol

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Wek, Kristen S. "Development of Polymeric Therapeutic Nanoparticles: Toward Targeted Delivery and Efficient ¹⁹F MRI of Solid Tumors." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1491168123379844.

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10

Alqarni, Ali. "Solubility Ratios, Encapsulation Efficiency, and Size of Beta-sitosterol Loaded Poly(Lactide)-Block-Poly(Ethylene glycol) Polymeric Micelles." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2019. http://digitalcommons.auctr.edu/cauetds/201.

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β-sitosterol/poly(ethylene glycol)-block-poly(lactic acid) (PLA-b-PEG) complexes were prepared by solution blending in purified water and ethanol. The mixture of water and ethanol is a suitable solvent system for the two components. The complex was studied by using Nuclear Magnetic Resonance (NMR) spectroscopy and Differential Scanning Calorimetry (DSC). β-sitosterol is a drug that may reduce the swelling of benign prostatic hyperplasia (BPH) and diminishing inflammation. However, it is hydrophobic and difficult to deliver in aqueous solution. Since PLA-b-PEG has amphiphilic properties, the co

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11

Reeds, Kimberly. "In vitro effects of canine Wharton’s jelly mesenchymal stromal cells and nanoparticles on canine osteosarcoma D17 cell viability." Thesis, Kansas State University, 2011. http://hdl.handle.net/2097/11990.

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Master of Science<br>Department of Clinical Sciences<br>Mary Lynn Higginbotham<br>Objectives – To isolate and maintain canine Wharton’s jelly mesenchymal stromal cells (WJMSCs) in culture, to determine the effects of micellar nanoparticles containing doxorubicin (DOX) on WJMSCs and canine osteosarcoma (OSA) D17 cell viability, and to determine the effects of conditioned media from WJMSCs loaded with micellar nanoparticles containing DOX on OSA D17 cell viability. Sample Population – Canine WJMSCs containing various concentrations of DOX micelles and canine OSA D17 cells. Procedures – WJMSCs

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12

Akasov, Roman. "Novel 3D in vitro models based on multicellular tumor spheroids to test anticancer drugs and drug delivery vehicles." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF013/document.

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Les sphéroïdes multicellulaires tumoraux (SMT) constituent un outil prometteur dans le domaine de l’étude biologique des tumeurs. Le but de la thèse était de développer une technique de la formation de SMT et de démontrer la disponibilité de ces sphéroïdes comme modèle in vitro 3D pour tester l’efficacité de principes actifs anticancéreux ainsi que celle de formulations de délivrance de médicaments. L'effet d’auto-assemblage de cellules induit par une addition des peptides RGD cycliques a été étudié pour 16 lignées cellulaires de différentes origines. Le peptide cyclique RGDfK et sa modificati

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13

Fugit, Kyle Daniel. "QUANTIFICATION OF FACTORS GOVERNING DRUG RELEASE KINETICS FROM NANOPARTICLES: A COMBINED EXPERIMENTAL AND MECHANISTIC MODELING APPROACH." UKnowledge, 2014. http://uknowledge.uky.edu/pharmacy_etds/37.

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Advancements in nanoparticle drug delivery of anticancer agents require mathematical models capable of predicting in vivo formulation performance from in vitro characterization studies. Such models must identify and incorporate the physicochemical properties of the therapeutic agent and nanoparticle driving in vivo drug release. This work identifies these factors for two nanoparticle formulations of anticancer agents using an approach which develops mechanistic mathematical models in conjunction with experimental studies. A non-sink ultrafiltration method was developed to monitor liposomal rel

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Adams, Monica L. "Chemically tailored polymeric micelles for drug delivery." 2003. http://www.library.wisc.edu/databases/connect/dissertations.html.

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Hao-HsiangChang and 張皓翔. "Fluorescent Polymeric Micelles with Oligofluorene Moieties as Nanocarriers for Curcumin and Doxorubicin." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/49413677844953600893.

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碩士<br>國立成功大學<br>化學工程學系碩博士班<br>101<br>In recent years, polymeric micelles formed from amphiphilic block copolymers have found a rich variety of applications in nanotechnology as drug delivery vehicles. Amphiphilic block copolymers can self-assemble into core-shell micelles with hydrophobic block as the core and hydrophilic as the shell in water. They can efficiently load hydrophobic drugs into its hydrophobic core and significantly improve its solubility. For drug delivery system, Polymeric micelles have several advantages of improving bioavailability of hydrophobic drugs and low critical micel

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Li, Yu-Lun, and 李毓倫. "Tumor Cell Targeting and Endocytosis Pathways of Doxorubicin Loaded Folate-Conjugated Polymeric Micelles." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/49896646013671045460.

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碩士<br>中原大學<br>生物醫學工程研究所<br>100<br>The specificity between normal cells and cancer cells in conventional chemotherapy is in-sufficient. The plasma surface of cancer cells is expressed various receptors depending on the physiological functions of the cells. Folate receptor (FR) is overexpressed in the apical membrane surface of certain cancer cells making a potential target of tumor therapeutics. Hence, in this study, folate-decorated micelles based on the star-shaped PCL-PEG copolymer were prepared for targeting to the folate receptor overexpressing in human oral cavity carcinoma cells (KB) and

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Chan, Dianna. "Polymeric Micelles for SiRNA and AON Delivery." Thesis, 2012. http://hdl.handle.net/1807/33368.

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Immuno-nanoparticles of poly(ᴅ,ʟ-lactide-co-2-methyl-2-carboxytrimethylene carbonate)-g-poly(ethylene glycol) (poly(LA-co-TMCC)-g-PEG) have been used to target breast cancer cells through the specific binding of trastuzumab antibodies to over-expressed human epidermal growth factor receptor 2 (HER2). Small interfering RNA (siRNA) and antisense oligonucleotides (AONs) disrupt the synthesis of select proteins. It is hypothesized that oligonucleotides coupled to polymeric immuno-nanoparticles can be used for gene silencing and specifically to target luciferase. The first objective is to demonstra

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Ho, Karyn. "Targeted Drug Delivery to Breast Cancer using Polymeric Nanoparticle Micelles." Thesis, 2012. http://hdl.handle.net/1807/34054.

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Broad distribution and activity limit the utility of anti-cancer compounds by causing unacceptable systemic toxicity and narrow therapeutic indices. To improve tumour accumulation, drug-loaded macromolecular assemblies have been designed to replace conventional surfactant-based formulations. Their nanoscale size enhances tumour accumulation via hyperpermeable vasculature and reduced lymphatic drainage. Incorporating targeting ligands introduces cell specificity through receptor-specific binding and uptake, enabling drugs to reach intracellular targets. In this work, the targeting propertie

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Po-WenLiao and 廖柏雯. "Multifunctional Polymeric Mixed Micelles for the Application of Drug Delivery System." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/41141929458246037670.

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Chia-WeiWang and 王嘉瑋. "Polymeric Micelles with Triple Stimuli-Responsive characteristics for Controlled Drug Release." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/3h6e84.

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Chung-HaoCheng and 鄭仲豪. "Photocleavable and Thermoresponsive Polymeric Micelles: Synthesis, Characterization, and Application in Drug Encapsulation." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/90214789171964615350.

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碩士<br>國立成功大學<br>化學工程學系碩博士班<br>100<br>In this study, a series of new photo- and thermo-sensitive amphiphilic block copolymers, poly(triethylene glycol methacrylate)-b-poly(o-nitrobenzyl methacrylate) (PTEGMA-b-PNBMA) was synthesized and the polymeric micelles of these copolymers self-assembled in aqueous solution were investigated. PNBMA was a photo-cleavable polymer and it was the hydrophobic block of the copolymers. After the irradiation of UV light, PNBMA was broken and transformed from hydrophobic to hydrophilic. PTEGMA was a thermo-responsive polymer. PTEGMA was hydrophilic below the lower

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Jen-IngChen and 陳正穎. "Photocleavable and Fluorescent Polymeric Micelles: Synthesis, Characterization, and Application in Drug Encapsulation." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/50275709672544961890.

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碩士<br>國立成功大學<br>化學工程學系碩博士班<br>100<br>The nanostructures and photophysical properties of the fluorescent polymeric micelles self-assembled from a series of new amphiphilic block copolymers, poly(ethylene glycol)-b-[polystyrene-co-poly(2-(1,2,3,4,5-pentaphenyl-1H-silol-1 -yloxy)ethyl methacrylate)] [PEG-b-(PS-co-PAIE), P3] and poly(ethylene glycol)-b -[poly(2-nitrobenzyl methacrylate)-co-poly(2-(1,2,3,4,5-pentaphenyl-1H-silol-1 -yloxy)ethyl methacrylate)] [PEG-b-(PNBMA-co-PAIE), P4], were investigated in this work. We chose PEG as the hydrophilic block, and a fluorescent pendent group with the s

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Huang, Yu-Hsin, and 黃于馨. "Development of pH-sensitive polymeric mixed micelles for anticancer drug delivery system." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/hqb92j.

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Yu-ShengKuo and 郭育勝. "Stimuli-responsive and Fluorescent Polymeric Micelles for the Application of Drug Delivery System." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/8qhted.

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碩士<br>國立成功大學<br>化學工程學系<br>102<br>In this study, we successfully synthesize a series of amphiphilic block copolymers PTEGMA-b-P(NBMA-co-AIE), containing thermo- and photo-responsive moieties and fluorophores with aggregation induced emission. These amphiphilic block copolymers could self-assemble in aqueous solution to form micelles due to their amphiphilic characteristic. The hydrophobic segments form the core and the hydrophilic segments form the corona of the micelles. Herein, the polymeric micelles are utilized as nanocarriers for the chemotherapy drug, doxorubicin (Dox), encapsulated by th

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Vakil, Ronak. "Polymeric micelle nanocarriers for the treatment of disseminated candidiasis /." 2006. http://www.library.wisc.edu/databases/connect/dissertations.html.

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Liao, Zhi-Sheng, and 廖智盛. "Ultrasensitive pH-Responsive Polymeric Micelles for High-Efficiency Anticancer Therapy and Controllable Drug Delivery." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/05654583505080670198.

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碩士<br>國立臺灣科技大學<br>應用科技研究所<br>105<br>This work has successfully constructed a polyurethane containing Ultrasensitive pH-Responsive ability. The new material can not only perform self-assembly of nano-scale micelles in aqueous solution, but also possess excellent drug-loading capability and adjustable drug-loading capacity. Besides, in the test of a long period of time, the micelles still represent highly durability and stability. In vitro test of the Macrophages (Raw 264.7), the behavior of the drug release can be well controlled by the pH value of the environment. Moreover, under weak acidic c

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YUN-CHU, WANG, and 王韻筑. "Studies on Intelligent Polymeric Micelles for Application in Controlled Drug Release and Photodynamic Therapy." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/85xvu6.

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碩士<br>國立中正大學<br>化學工程研究所<br>102<br>The utilization of drugs delivery system to treat tumors have been widely studided in recent years. Intelligent materials that respond to specific stimuli, such as temperature, pH, or enzymatic activity have been attracted great attention. In addition, the photodynamic therapy (PDT) is a novel and noninvasive technique for certain kinds of cancer tumor treatment, which utilized photosensitizer, oxygen and light together to generate singlet oxygen to induce apoptosis of tumor tissue. Herein, we use atom transfer radical polymerization (ATRP) and ring opening po

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Ling-TaoChi and 紀凌濤. "Enhancement of Drug-Loading Capability for the Polymeric Micelles via Co-Encapsulation with Triglyceride." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/54k6yz.

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碩士<br>國立成功大學<br>化學工程學系<br>105<br>In this study, we developed a novel, dual-sensitive drug carrier based on polymeric micelles co-assembled from amphiphilic block copolymers, [PCL-b-P(TEGMA-co-AHA)] (PTAHA), with tricaprin, a kind of medium-chain triglyceride (MCT). PTEGMA possessed thermo-sensitive and AHA performed pH-sensitive in aqueous solution. The micelles, PTAHA/MCT, were designed to improve capability of Doxorubicin (DOX) loading and compared to blank micelles, PTAHA, as control. Among micelles, PCL and MCT formed a mixed hydrophobic domain known as micellar emulsion to encapsulate DOX

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YI-CHEN, CHEN, and 陳怡辰. "Characterization of Amphiphilic Polymeric Micelles as a Drug Carrier and Pharmacokinetic Study in Rats." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/96543591162595968758.

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碩士<br>國立臺灣大學<br>藥學研究所<br>91<br>Micelles formed from amphiphilic copolymers have been explored in recent years as carriers for hydrophobic drugs. The hydrophobic micelle core serves as a microenvironment for the incorporation of lipophilic drugs, while the corona shell serves as a stabilizing interface between the hydrophobic core and the external medium. In our studies, three kinds of monomers (e-caprolactone, d-valerolactone and L-lactide) and poly(ethyl glycol)s with different molecular weights (PEG4000 and PEG10000) were used to prepare triblock copolymers. A dialysis method was

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Parra, Ana Isabel Xavier Pinto. "Internship Reports and Monograph entitled "Polymeric Micelles: A promising pathway for dermal drug delivery"." Master's thesis, 2021. http://hdl.handle.net/10316/98954.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>No âmbito da realização do Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas da Faculdade de Farmácia da Universidade de Coimbra, o presente trabalho apresenta sob a forma de uma Análise SWOT (Pontos Fortes, Pontos Fracos, Oportunidades, Ameaças) os relatórios de estágio relativos ao Estágio Curricular em Farmácia Comunitária na Farmácia Alves e ao Estágio Curricular na Direção da Qualidade & Investigação da SONAE MC. Na terceira parte, este trabalho contém a Monografia

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SUN, Ya-Ting, and 孫雅庭. "Supramolecular Polymeric Micelles Constructed by Self-Complementary Multiple Hydrogen Bonding for Controlled Drug Delivery." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/7bh7c6.

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碩士<br>國立臺灣科技大學<br>應用科技研究所<br>107<br>Facile construction of supramolecular polymers, based on the incorporation of multiple hydrogen bonds, with the desired chemical and physical properties to achieve the effective, safe and reliable delivery of drugs for chemotherapy treatment remains highly challenging. In this thesis, we successfully developed new supramolecular polymers containing self-complementary quadruple/sextuple hydrogen bonding groups, which undergo spontaneous assembling into nanospherical micelles in an aqueous environment. This system generates supramolecular micelles that can be

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Lee, Helen Hoi Ning. "Roles of Passively and Actively Targeted Block Copolymer Micelles in Cancer Therapy." Thesis, 2010. http://hdl.handle.net/1807/26365.

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Nanoparticle-based drug delivery systems (NDDS) have emerged as a promising strategy for formulation of anticancer drugs due to their ability to passively target solid tumors via exploitation of the enhanced permeation and retention effect. In particular, nano-sized block copolymer micelles (BCMs) have proven to be a viable delivery vehicle for hydrophobic anticancer drugs. To further enhance the specificity of BCMs towards cancer cells, extensive research has been focused on the formulation of actively targeted BCMs with tumor cell binding antigens conjugated to their surface. However, the

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Hsing-ChunChen and 陳興群. "Functional Polymeric Mixed Micelles Based on Amphiphilic Copolymers: Preparation, Characterization, and Application in Drug Carriers." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/8ksxjd.

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碩士<br>國立成功大學<br>化學工程學系<br>104<br>In this study, we prepare a mixed micelle system as drug carriers. The mixed micelles were co-assembled of three amphiphilic copolymers, [PCL-b-P(TEGMA-co-FA)], [PCL-b-P(TEGMA-co-AHA)] and [PCL-b-P(TEGMA-co-(PPS-HEMA))]. PCL block is hydrophobic and used as the core of micelle to encapsulate hydrophobic drug, DOX. PTEGMA block is thermo-sensitive and acts as the hydrophilic shell of micelle. In addition, we introduced the pH-sensitive, active targeting and fluorescent monomer (AHA, FA and PPS-HEMA) to the hydrophilic block by copolymerization the corresponding

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Wang, Yu-Ting, and 王昱婷. "Preparation of PLGA conjugated with different generation polyurethane dendrimers polymeric micelles and study on drug delivery." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/k9m7xv.

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碩士<br>嘉南藥理大學<br>生物科技系<br>102<br>Drug delivery system to improve the efficacy of treatment have a considerable types. In recent years some studies indicate that polymer nano-micelles can be used as delivery vehicles for drug with lower solubility. Polymeric micelles usually consists of amphiphilic copolymer. The purpose of this study is to design amphiphilic copolymer to form polymeric micelles. Hydrophobic side of the copolymer form the core, and then dendrimer hydrophilic end stabilize the particles in the aqueous medium. The amphiphilic copolymer was obtained through the reaction between the

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CHIH-CHANG, LIN, and 林志昌. "In vivo Tissue Distribution an In vitro Anticancer Activity of Polymeric Micelles as a Drug Carrier." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/53830499909344862743.

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碩士<br>國立臺灣大學<br>藥學研究所<br>91<br>Recently, micelles have been well studied with the use of biodegradable amphiphilic block copolymers. The lypophilic segments of copolymers are assembled in aqueous media to form micelles with a core-shell structure above critical micellar concentration. With this character, micelles can become ideal carriers for water insoluble drugs. In the first part of this study, the copolymers were synthesized by a ring-opening polymerization of three kinds of lactones monomer (e-caprolactone、d-valerolactone and L-lactide) initiated with hydroxyl-terminated polye

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Chi-MingHuang and 黃祈銘. "Stimuli-responsive and Targeting Polymeric Micelles for the Applications of Controlled Drug Release and Target Delivery." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/40019228348250310986.

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碩士<br>國立成功大學<br>化學工程學系碩博士班<br>101<br>In this work, a new series of mixed polymeric micelles with multi-functionalities was investigated and their application as the carrier of anti-cancer drugs was explored. These micelles were self-assembled from two amphiphilic diblock copolymers, poly(ɛ-caprolactone)-b-poly[triethylene glycol methacrylate-co- 6-(methacrylamido)hexanoic acid] [PCL-b-P(TEGMA-co-AHA)] and poly(ɛ-caprolactone)-b-poly[triethylene glycol methacrylate-co- N-(2-(methacrylamido)ethyl) folatic amide] [PCL-b-P(TEGMA-co-FA)]. The hydrophobic core of micelles composed of the PCL block c

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El, Sabahy Mahmoud. "Polymeric micelles as versatile carriers for drugs and nucleic acids." Thèse, 2009. http://hdl.handle.net/1866/3481.

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Le cancer est la principale cause de mortalité au Canada. Les taxanes (e.g. le paclitaxel et le docétaxel (DCTX)) constituent des remèdes efficaces contre une série de tumeurs solides telles que les cancers du sein, du poumon et de l’ovaire. Par ailleurs, des acides nucléiques (e.g. les oligonucléotides antisens (AON) ou les petits ARN interférents (siRNAs)), capables de supprimer sélectivement certains oncogènes impliqués dans la carcinogénèse, sont actuellement étudiés pour traiter une large gamme de cancers. Bien que l’activité des taxanes et des acides nucléiques soit bien établie sur des

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Chen, Wen-Ju, and 陳文如. "N-isopropylacrylamide Copolymers for the Preparation of Thermo- and pH- Sensitive Polymeric Micelles: Application for Drug Delivery." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/97245249275199064672.

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碩士<br>南台科技大學<br>電機工程系<br>97<br>ABSTRACT In this work, fluorescently labeled smart micelle copolymers which consist of Dioctadecylamine-501 (DODA-501) as the hydrophobic segment, N-isopropylacrylamide (NIPAAm) as well as acrylic acid (AAc) as the hydrophilic segments were prepared. These micelles showed both thermo- and pH-sensitive properties due to the nature properties of NIPAAm and AAc, respectively. The particle size of the prepared micelles ranged from 94～200 nm and was found to increase with DODA-501 concentration. The size of particles varied in different pH mediums or different tempera

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Francis, Mira. "Engineering polymeric micelles for solubilization of poorly-water soluble drugs : a novel approach for oral drug delivery." Thèse, 2005. http://hdl.handle.net/1866/15629.

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Shi-HaoWang and 王士豪. "Preparation of Fluorescent Polymeric Mixed Micelles for Monitoring Drug Encapsulation and Release via Forster Resonance Energy Transfer." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/rfpjaj.

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Kuo, Hsuan-Ting, and 郭炫廷. "Superparamagnetic Iron Oxide Nanoparticles Encapsulated in Polyethylene Glycol Modified Polymeric Micelles for MRI-Guided Drug and Gene Delivery." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/14675568928300475057.

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碩士<br>國立臺灣大學<br>醫學工程學研究所<br>98<br>Over the past several years, cancer has become one of the most devastating diseases worldwide. Nowadays, cancer treatment is much dependent on surgery, chemotherapy and radiotherapy. However, these methods were less successful and had major side effects. In order to improve the efficiency of cancer treatment, we focus on the development of multifunctional polymeric micelles for drug delivery, gene therapy and diagnostic imaging application. The developed polymeric micelles were composed of a hydrophobic stearic acid (SA) core and a positively charged polyethyl

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Chih-HaoCheng and 鄭至浩. "Polymeric Mixed Micelles with Triple Stimuli-Responsive Characteristics and Forster Resonance Energy Transfer Phenomenon for Drug Delivery System." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/z944e9.

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Hsu, Ning-Yu, and 徐寧妤. "Investigation of pH-Sensitive Vitamin E-contained Polymeric Micelles to Induce Apoptosis for Cancer Cells in Drug Delivery System." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/17753549876747735261.

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碩士<br>國立陽明大學<br>醫學工程研究所<br>102<br>α-Tocopheryl succinate (α-TOS), an analogue of vitamin E, can induce apoptosis in cancer cells, while exhibiting low toxicity in normal cells. In this study, the block copolymer, methoxy poly(ethylene glycol)-block-poly (hydroxypropyl methacrylate) (mPEG-b-PHPMA) was designed as the hydrophilic main chain. The hydrophobic α-TOS and pH-sensitive histidine were grafted onto the block copolymer by coupling reaction, forming comb-like copolymer, mPEG-b-P(HPMA-g-α-TOS-g- His). The copolymers were self-assembled into polymeric micelles which loaded with both antica

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Richter, Annett [Verfasser]. "Polymeric micelles and dendritic amphiphiles for the anticancer drug sagopilone : solubilization, formulation development, and toxicity assessment / vorgelegt von Annett Richter." 2010. http://d-nb.info/1004808763/34.

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Gaurav, Raval. "Thermodynamic and Spectroscopic Studies on the Molecular Interaction of Doxorubicin (DOX) with Negatively Charged Polymeric Nanoparticles." Thesis, 2012. http://hdl.handle.net/1807/33509.

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The aim of this study was to investigate the molecular interactions of the anti-cancer drug Doxorubicin (DOX) with poly(methacrylic acid) grafted starch nanoparticles (PMAA-g-St). In order to fully understand the DOX/PMAA-g-St system, we conducted in-depth studies on DOX dimer dissociation and DOX/PMAA-g-St binding interactions using various techniques such as isothermal titration calorimetry (ITC), dynamic light scattering (DLS), and fluorescence and absorption spectroscopy. Based on our experimental results, we developed a quantitative thermodynamic model with relevant parameters such as dis

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Huynh, Loan. "Rational Design of Drug Formulations using Computational Approaches." Thesis, 2012. http://hdl.handle.net/1807/35730.

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Theory has been used to complement experiment in the development of both drugs and delivery systems. Theoretical methods are capable of identifying the molecular basis of drug formulation inadequacies and systematic theoretical studies may suggest fruitful avenues for material modification. This thesis highlights the utility of computer-based theoretical calculations for guiding the design of drug formulations and enhancing material-drug compatibility and stability. Specifically, the present work explores the applications of semi-empirical methods and atomistic molecular dynamics (MD) simulati

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Singh, Vikramjit. "Enhanced functionality of monodispersed polymeric nanocarriers in medicine." Thesis, 2012. http://hdl.handle.net/2152/26082.

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Polymeric monodispersed nanocarriers with controlled shape and size have been fabricated in the literature primarily using top down processes such as imprint lithography. In this dissertation, the geometric and material property limits of imprint based techniques have been studied. The resulting insight has led to the creation of new processes that significantly extend the limits of imprint processes in several ways: (i) Ability to print nanocarriers with ultra-soft biomaterials (<1MPa modulus); (ii) Sub-50nm diameter cylindrical particles with >3:1 aspect ratio with >5x enhanced wafer yield;

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Rebanda, Magda Mora. "Poly : l-lactide-co-caprolactone-co-glycolide : based nanocarriers for drug delivery : synthesis optimization and cellular studies." Master's thesis, 2018. http://hdl.handle.net/10400.14/30648.

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Nanomedicine has viewed countless breakthroughs in drug implementation. Nanomaterials have been used to enable enhanced drug delivery to tumor cells with lower toxicity to healthy ones. Controlled Drug Delivery Systems (DDS) have several advantages compared to the traditional forms of drugs. Indeed, when a drug is transported efficiently to the place of action its influence on vital tissues and undesirable side effects can be significantly minimized. Its accumulation at the target site increases and, consequently, the required doses are lower. Different nanoparticles (NPs) have been developed

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Σεργίδης, Ανδρέας. "Μελέτη των παραμέτρων της σύνθεσης υβριδικών κολλοειδών νανοκρυστάλλων με υπερπαραμαγνητικές ιδιότητες για την ανάπτυξη πολυλειτουργικών συστημάτων ελεγχόμενης χορήγησης αντικαρκινικών ουσιών". Thesis, 2014. http://hdl.handle.net/10889/8576.

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Η Πακλιταξέλη (PTX) αποτελεί ένα ευρέως διαδεδομένο αντινεοπλασματικό φάρμακο και ενδείκνυται σε μεταστατικό καρκίνο του μαστού, καρκίνο ωοθηκών, μη μικροκυτταρικό καρκίνο του πνεύμονα και σε σάρκωμα Kaposi ασθενών με AIDS. Παρ’ όλα αυτά, η σημαντική τοξικότητα που εμφανίζει (μυελοκαταστολή, νευροτοξικότητα, αντιδράσεις υπερευαισθησίας), υπογραμμίζει την αναγκαιότητα για μορφοποίησή της σε Συστήματα Ελεγχόμενης Χορήγησης Φαρμάκων (DDS), με σκοπό τη μείωση των ανεπιθύμητων ενεργειών και την αύξηση της βιοδιαθεσιμότητας του φαρμάκου. Τα πολυμερικά μικκύλια έχουν μελετεθεί εκτενώς τα τελευταία

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