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Journal articles on the topic 'Polymeric micelles Doxorubicin Drug'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Wang, Jing, Xueqing Xing, Xiaocui Fang, et al. "Cationic amphiphilic drugs self-assemble to the core–shell interface of PEGylated phospholipid micelles and stabilize micellar structure." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 371, no. 2000 (2013): 20120309. http://dx.doi.org/10.1098/rsta.2012.0309.

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Since polymeric micelles are promising and have potential in drug delivery systems, people have become more interested in studying the compatibility of polymeric carriers and drugs, which might help them to simplify the preparation method and increase the micellar stability. In this article, we report that cationic amphiphilic drugs can be easily encapsulated into PEGylated phospholipid (PEG–PE) micelles by self-assembly method and that they show high encapsulation efficiency, controllable drug release and better micellar stability than empty micelles. The representative drugs are doxorubicin

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2

Zhang, Yixin, Song Luo, Yan Liang, et al. "Synthesis, characterization, and property of biodegradable PEG-PCL-PLA terpolymers with miktoarm star and triblock architectures as drug carriers." Journal of Biomaterials Applications 32, no. 8 (2018): 1139–52. http://dx.doi.org/10.1177/0885328217751247.

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A series of amphiphilic terpolymers with miktoarm star and triblock architectures of poly(ethylene glycol) (PEG), poly(ε-caprolactone) (PCL) and poly(l-lactide acid) (PLLA) or poly(DL-lactide acid) (PDLLA) terpolymers were synthesized as carriers for drug delivery. The architecture, molecular weight and crystallization behavior of the terpolymers were characterized. Anticancer drug doxorubicin was encapsulated in the micelles to investigate their drug loading properties. The miktoarm star terpolymers exhibited stronger crystallization capability, smaller size and better stability than that of

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3

Zhang, Hai, Jianqin Yan, Heng Mei, et al. "High-drug-loading capacity of redox-activated biodegradable nanoplatform for active targeted delivery of chemotherapeutic drugs." Regenerative Biomaterials 7, no. 4 (2020): 359–69. http://dx.doi.org/10.1093/rb/rbaa027.

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Abstract Challenges associated with low-drug-loading capacity, lack of active targeting of tumor cells and unspecific drug release of nanocarriers synchronously plague the success of cancer therapy. Herein, we constructed active-targeting, redox-activated polymeric micelles (HPGssML) self-assembled aptamer-decorated, amphiphilic biodegradable poly (benzyl malolactonate-co-ε-caprolactone) copolymer with disulfide linkage and π-conjugated moieties. HPGssML with a homogenous spherical shape and nanosized diameter (∼150 nm) formed a low critical micellar concentration (10−3 mg/mL), suggesting good

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4

Wen, Weiqiu, Chong Guo, and Jianwei Guo. "Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery." Nanomaterials 11, no. 1 (2021): 188. http://dx.doi.org/10.3390/nano11010188.

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Four-arm star-shaped (denoted as ‘S’) polymer adamantane-[poly(lactic-co-glycolic acid)-b-poly(N,N’-diethylaminoethyl methacrylate) poly(ethylene glycol) monomethyl ether]4 (S-PLGA-D-P) and its linear (denoted as ‘L’) counterpart (L-PLGA-D-P) were synthesized, then their self-assembled micelles were further developed to be platforms for anticancer drug delivery. Two types of polymeric micelles exhibited strong pH-responsiveness and good drug loading capacity (21.6% for S-PLGA-D-P and 22.9% for L-PLGA-D-P). Using doxorubicin (DOX) as the model drug, their DOX-loaded micelles displayed well cont

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5

Zhou, Xin Xin, Long Jin, Rui Qun Qi, and Teng Ma. "pH-responsive polymeric micelles self-assembled from amphiphilic copolymer modified with lipid used as doxorubicin delivery carriers." Royal Society Open Science 5, no. 3 (2018): 171654. http://dx.doi.org/10.1098/rsos.171654.

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In the present study, a novel pH-responsive amphiphilic copolymer, 1,2-distearoyl- sn -glycero-3-phosphoethanolamine- N -[methoxy(polyethylene glycol)] conjugated poly(β-amino esters) (DSPE- b -PEG- b -PAE- b -PEG- b -DSPE), was designed and successfully synthesized via Michael-type step polymerization. The chemical structure of the pentablock copolymer was confirmed with proton nuclear magnetic resonance ( 1 H-NMR) and Fourier transform infrared (FT-IR) spectroscopy. The copolymer was able to self-assemble into core/shell polymeric micelles in aqueous solution at low concentrations, and its c

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Emami, Jaber, Moloud Kazemi, and Mina Mirian. "Synthesis and in vitro evaluation of self-assembling biocompatible heparin-based targeting polymeric micelles for delivery of doxorubicin to leukemic cells." Research in Pharmaceutical Sciences 20, no. 1 (2025): 142–64. https://doi.org/10.4103/rps.rps_197_24.

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Background and purpose: Biodegradable polymeric micelles have emerged as one of the most promising platforms for targeted drug delivery. In the present study, a polymeric micelle composed of folic acid (FA), heparin (HEP), dexamethasone (DEX), and (FA-PEG-HEP-CA-TOC) was developed for the delivery of doxorubicin (DOX) to leukemic cells. Experimental approach: FA-HEP-DEX was synthesized and characterized by 1H-NMR. DOX-loaded micelles were prepared using a dialysis method. The impact of various processing variables, including polymer-to-drug ratio, dialysis temperature, and solvent type, on the

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Romero, Jocelyn Fernanda, Svenja Herziger, Mariam Cherri, et al. "Dendritic Glycerol-Cholesterol Amphiphiles as Drug Delivery Systems: A Comparison between Monomeric and Polymeric Structures." Pharmaceutics 15, no. 10 (2023): 2452. http://dx.doi.org/10.3390/pharmaceutics15102452.

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The application of micelles as drug delivery systems has gained a great deal of attention as a means to overcome the current several drawbacks present in conventional cancer treatments. In this work, we highlight the comparison of polymeric and monomeric amphiphilic systems with a similar hydrophilic–lipophilic balance (HLB) in terms of their biocompatibility, aggregation behavior in aqueous solution, and potential in solubilizing hydrophobic compounds. The polymeric system consists of non-ionic polymeric amphiphiles synthesized via sequential RAFT polymerization of polyglycerol first-generati

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8

Jiang, Junting, Junbo Li, Biyu Zhou, et al. "Fabrication of Polymer Micelles with Zwitterionic Shell and Biodegradable Core for Reductively Responsive Release of Doxorubicin." Polymers 11, no. 6 (2019): 1019. http://dx.doi.org/10.3390/polym11061019.

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To achieve a high stability in physiological environment and rapid intracellular drug release, a biodegradable zwitterionic triblock copolymer with a disulfide-linked poly-ε-caprolactone and polycarboxybetaine methacrylate (PCBMA-SS-PCL-SS-PCBMA) was prepared for micellar carrier to delivery doxorubicin (DOX) into tumor cells. PCBMA-SS-PCL-SS-PCBMA was obtained by following steps: i) introducing disulfide bonds through end-group modification of PCL diol with cystamine dihydrochloride; ii) preparing PCL-RAFT macromolecular chain transfer agent by EDC/NHS chemistry; iii) RAFT polymerization of z

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9

Ramesh, Kalyan, Avnish Kumar Mishra, Jin Kon Kim, Yeon Tae Jeong, Yeong-Soon Gal, and Kwon Taek Lim. "Preparation of Doxorubicin-Loaded Amphiphilic Poly(D,L-Lactide-Co-Glycolide)-b-Poly(N-Acryloylmorpholine) AB2 Miktoarm Star Block Copolymers for Anticancer Drug Delivery." Materials 13, no. 17 (2020): 3713. http://dx.doi.org/10.3390/ma13173713.

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Owing to their unique topology and physical properties, micelles based on miktoarm amphiphilic star block copolymers play an important role in the biomedical field for drug delivery. Herein, we developed a series of AB2-type poly(D,L-lactide-co-glycolide)-b-poly(N-acryloyl morpholine) (PLGA-b-PNAM2) miktoarm star block copolymers by reversible addition–fragmentation chain–transfer polymerization and ring-opening copolymerization. The resulting miktoarm star polymers were investigated by 1H NMR spectroscopy and gel permeation chromatography. The critical micellar concentration value of the mice

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Choi, Young, Eun-sook Choi, Kwan Mun, et al. "Dual-responsive Gemini Micelles for Efficient Delivery of Anticancer Therapeutics." Polymers 11, no. 4 (2019): 604. http://dx.doi.org/10.3390/polym11040604.

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Polymeric micelles as drug delivery vehicles are popular owing to several advantages. In this study, a gemini amphiphile (gemini mPEG-Cys-PMT) consisting of hydrophilic poly(ethylene glycol) and hydrophobic poly(methionine) with cystine disulfide spacer was synthesized and its micellar properties for thiol- or reactive oxygen species (ROS)-dependent intracellular drug delivery were described. The cleavage of cystine linkage in a redox environment or the oxidation of methionine units in a ROS environment caused the destabilization of micelles. Such redox- or ROS-triggered micellar destabilizati

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11

Sawdon, Alicia, Jun Zhang, Xutu Wang, and Ching-An Peng. "Enhanced Anticancer Activity of 5’-DFUR-PCL-MPEG Polymeric Prodrug Micelles Encapsulating Chemotherapeutic Drugs." Nanomaterials 8, no. 12 (2018): 1041. http://dx.doi.org/10.3390/nano8121041.

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The compound 5’-deoxy-5-fluorouridine (5’-DFUR) is a prodrug of the anti-tumor drug 5-fluorouracil (5-FU). Thymidine phosphorylase (TP) is an enzyme that can convert 5’-DFUR to its active form 5-FU and the expression of TP is upregulated in various cancer cells. In this study, 5’-DFUR associated with amphiphilic copolymer poly(ε-caprolactone)-methoxy poly(ethylene glycol) (5’-DFUR-PCL-MPEG) was synthesized, characterized, and self-assembled into functional polymeric micelles. To demonstrate that the prodrug 5’-DFUR could convert into cytotoxic 5-fluorouracil (5-FU) by endogenous TP, HT-29 colo

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12

Brewer, Kyle, Fengxiang Bai, and Anton Blencowe. "pH-Responsive Poly(ethylene glycol)-b-poly(2-vinylpyridine) Micelles for the Triggered Release of Therapeutics." Pharmaceutics 15, no. 3 (2023): 977. http://dx.doi.org/10.3390/pharmaceutics15030977.

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The use of pH-responsive polymeric micelles is a promising approach to afford the targeted, pH-mediated delivery of hydrophobic drugs within the low-pH tumour milieu and intracellular organelles of cancer cells. However, even for a common pH-responsive polymeric micelle system—e.g., those utilising poly(ethylene glycol)-b-poly(2-vinylpyridine) (PEG-b-PVP) diblock copolymers—there is a lack of available data describing the compatibility of hydrophobic drugs, as well as the relationships between copolymer microstructure and drug compatibility. Furthermore, synthesis of the constituent pH-respons

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13

Cheng, Xinfeng, Huixian Li, Xiaomeng Sun, et al. "Visible-Light-Induced Diselenide-Crosslinked Polymeric Micelles for ROS-Triggered Drug Delivery." Molecules 29, no. 16 (2024): 3970. http://dx.doi.org/10.3390/molecules29163970.

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To synthesize an effective and versatile nano-platform serving as a promising carrier for controlled drug delivery, visible-light-induced diselenide-crosslinked polyurethane micelles were designed and prepared for ROS-triggered on-demand doxorubicin (DOX) release. A rationally designed amphiphilic block copolymer, poly(ethylene glycol)-b-poly(diselenolane diol-co-isophorone diisocyanate)-b-poly(ethylene glycol) (PEG-b-PUSe-b-PEG), which incorporates dangling diselenolane groups within the hydrophobic PU segments, was initially synthesized through the polycondensation reaction. In aqueous media

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14

Kuang, Gaizhen, Qingfei Zhang, Shasha He, Yanjuan Wu, and Yubin Huang. "Reduction-responsive disulfide linkage core-cross-linked polymeric micelles for site-specific drug delivery." Polymer Chemistry 11, no. 44 (2020): 7078–86. http://dx.doi.org/10.1039/d0py00987c.

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15

Cheng, Lulu, Tingting Luan, Di Liu, et al. "Diblock copolymer glyco-nanomicelles constructed by a maltoheptaose-based amphiphile for reduction- and pH-mediated intracellular drug delivery." Polymer Chemistry 9, no. 11 (2018): 1337–47. http://dx.doi.org/10.1039/c7py01601h.

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16

Zhai, Jingming, Biyu Zhou, Yanhui An, Binzhong Lu, Yonggang Fan, and Junbo Li. "Galactosamine-Conjugating Zwitterionic Block Copolymer for Reduction-Responsive Release and Active Targeted Delivery of Doxorubicin to Hepatic Carcinoma Cells." Journal of Nanomaterials 2020 (April 20, 2020): 1–11. http://dx.doi.org/10.1155/2020/7863709.

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Nanocarriers with integrated advantage, such as excellent stealth property, active targeting function, and rapid intracellular drug release, are significant for cancer treatment. Herein, a biodegradable zwitterionic triblock copolymer containing disulfide-linked poly-ε-caprolactone and polycarboxybetaine methacrylate (PCB-SS-PCL-SS-PCB) was first synthesized and then partly modified with galactosamine (GAL) for constructing polymeric micelle drug carrier with multifunctionality. Polymeric micelles showed ultralow protein absorption in serum and obvious reduction-responsiveness in the presence

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17

Xu, Jing, Benkai Qin, Shujuan Luan, et al. "Acid-labile poly(ethylene glycol) shell of hydrazone-containing biodegradable polymeric micelles facilitating anticancer drug delivery." Journal of Bioactive and Compatible Polymers 33, no. 2 (2018): 119–33. http://dx.doi.org/10.1177/0883911517715658.

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Biodegradable pH-sensitive amphiphilic block polymer (mPEG-Hyde-PLGA) was synthesized via ring-opening polymerization, initiated from a hydrazone-containing macro-initiator. In this way, a pH-sensitive hydrazone bond was inserted into the backbone of block copolymer, linking hydrophilic poly(ethylene glycol) segment and hydrophobic poly(lactic-co-glycolic acid) segment. The copolymer self-assembled to form stable micelles with mean diameters below 100 nm and served as a drug delivery system for doxorubicin, with drug loading content of 5.3%. pH sensitivity of the hydrazone-containing micelles

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18

Radeva, Lyubomira, Yordan Yordanov, Ivanka Spassova, Daniela Kovacheva, Virginia Tzankova, and Krassimira Yoncheva. "Double-Loaded Doxorubicin/Resveratrol Polymeric Micelles Providing Low Toxicity on Cardiac Cells and Enhanced Cytotoxicity on Lymphoma Cells." Pharmaceutics 15, no. 4 (2023): 1287. http://dx.doi.org/10.3390/pharmaceutics15041287.

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The anthracycline antibiotic doxorubicin is a well-known antitumour agent, however its cardiotoxicity is a significant obstacle to therapy. The aim of the present study was to improve the safety of doxorubicin through its simultaneous encapsulation with a cardioprotective agent (resveratrol) in Pluronic micelles. The formation and double-loading of the micelles was performed via the film hydration method. Infrared spectroscopy proved the successful incorporation of both drugs. X-ray diffraction analyses revealed that resveratrol was loaded in the core, whereas doxorubicin was included in the s

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Bai, Lan, Fei Song, Xiao-hui Wang, et al. "Ligand–metal-drug coordination based micelles for efficient intracellular doxorubicin delivery." RSC Advances 5, no. 59 (2015): 47629–39. http://dx.doi.org/10.1039/c5ra05747g.

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20

Lo, Yu-Lun, Yao-Hsing Fang, Yen-Ju Chiu, et al. "Light- and Redox-Responsive Block Copolymers of mPEG-SS-ONBMA as a Smart Drug Delivery Carrier for Cancer Therapy." Pharmaceutics 14, no. 12 (2022): 2594. http://dx.doi.org/10.3390/pharmaceutics14122594.

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The development of stimuli-responsive polymeric micelles for targeted drug delivery has attracted much research interest in improving therapeutic outcomes. This study designs copolymers responsive to ultraviolet (UV) light and glutathione (GSH). A disulfide linkage is positioned between a hydrophilic poly(ethylene glycol) monomethyl ether (mPEG) and a hydrophobic o-nitrobenzyl methacrylate (ONBMA) to yield amphiphilic copolymers termed mPEG-SS-pONBMA. Three copolymers with different ONBMA lengths are synthesized and formulated into micelles. An increase in particle size and a decrease in criti

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Li, Yuxi. "pH-Sensitive Polymeric Nanoparticles for Effective Delivery of Doxorubicin." Highlights in Science, Engineering and Technology 65 (August 29, 2023): 37–42. http://dx.doi.org/10.54097/hset.v65i.11229.

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pH-responsive micelles beam nanoparticles were created using the self-assembly of PEG-Shiff-DOX medication. Under normal circumstances, these nanoparticles have great storage stability for more than a week, however they will degrade fast in a weak acidic environment. We saw a process-dependent drug release behaviour. This could lead to higher intracellular drug concentrations and a more sustained effect. The anti-tumor efficacy of nanoparticles on HeLa cells is superior to that of free DOX, according to the CCK-8 analysis. The potential for creating conversion DOX formulations for the treatmen

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Xiong, Di, Liyang Wen, Shiyuan Peng, Jianchang Xu, and Lijuan Zhang. "Reversible Cross-Linked Mixed Micelles for pH Triggered Swelling and Redox Triggered Degradation for Enhanced and Controlled Drug Release." Pharmaceutics 12, no. 3 (2020): 258. http://dx.doi.org/10.3390/pharmaceutics12030258.

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Good stability and controlled drug release are important properties of polymeric micelles for drug delivery. A good candidate for drug delivery must have outstanding stability in a normal physiological environment, followed with low drug leakage and side effects. Moreover, the chemotherapeutic drug in the micellar core should also be quickly and “on-demand” released in the intracellular microenvironment at the tumor site, which is in favor of overcoming multidrug resistance (MDR) effects of tumor cells. In this work, a mixed micelle was prepared by the simple mix of two amphiphilic copolymers,

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Wang, Yuyan. "Polymeric Micelles for Cancer Drug Delivery and Targeting." E3S Web of Conferences 290 (2021): 01014. http://dx.doi.org/10.1051/e3sconf/202129001014.

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Over the past years, the emergence of various therapeutic approaches has attracted so much consideration, but chemotherapy remains the most effective way in experimental practice. However, due to obstacles and difficulties, there is a limitation for the additional clinical presentation of the outdated chemical treatments such as paclitaxel and doxorubicin. Some of the barriers are severe side effects, profound cytotoxicity, and low therapeutic efficacy. Drug delivery systems (DDS) such as polymeric micelles have been technologically advanced over the recent decades to advance the treatment eff

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Yang, Yang, Fuwei Yang, Xiaotian Shan, et al. "Fabrication of pH/Reduction Sensitive Polyethylene Glycol-Based Micelles for Enhanced Intracellular Drug Release." Pharmaceutics 13, no. 9 (2021): 1464. http://dx.doi.org/10.3390/pharmaceutics13091464.

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At present, the drug is still difficult to release completely and quickly only with single stimulation. In order to promote the rapid release of polymeric micelles at tumor site, pH/reduction sensitive polymers (PCT) containing disulfide bonds and orthoester groups were synthesized. The PCT polymers can self-assemble in water and entrap doxorubicin to form drug-loaded micelles (DOX/PCT). In an in vitro drug release experiment, the cumulative release of DOX/PCT micelles in the simulated tumor microenvironment (pH 5.0 with GSH) reached (89.7 ± 11.7)% at 72 h, while it was only (16.7 ± 6.1)% in t

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Efthimiadou, Eleni. "New approach in synthesis, characterization and release study of pH-sensitive polymeric micelles, based on PLA-Lys-b-PEGm, conjugated with doxorubicin." Journal of nanoparticle research 13, no. 12 (2011): 6725–36. https://doi.org/10.1007/s11051-011-0579-5.

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Amphiphilic block copolymers are well established as building blocks for the preparation of micellar drug carriers. The functional polymer micelles possess several advantages, such as high drug efficiency, targeted delivery, and minimized cytotoxicity. The synthesis of block copolymers using nanostructured templates has emerged as a useful and versatile approach for preparing drug carriers. Here, we report the synthesis of a smart polymeric compound of a diblock PLA-Lys-b-PEG copolymer containing doxorubicin. We have synthesized functionalized diblock copolymers, with lysinol, poly(lactide) an

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Senevirathne, Suchithra A., Katherine E. Washington, Jason B. Miller, et al. "HDAC inhibitor conjugated polymeric prodrug micelles for doxorubicin delivery." Journal of Materials Chemistry B 5, no. 11 (2017): 2106–14. http://dx.doi.org/10.1039/c6tb03038f.

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Zlotnikov, Igor D., Dmitriy A. Streltsov, Alexander A. Ezhov, and Elena V. Kudryashova. "Smart pH- and Temperature-Sensitive Micelles Based on Chitosan Grafted with Fatty Acids to Increase the Efficiency and Selectivity of Doxorubicin and Its Adjuvant Regarding the Tumor Cells." Pharmaceutics 15, no. 4 (2023): 1135. http://dx.doi.org/10.3390/pharmaceutics15041135.

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The main factors that determine the low effectiveness of chemotherapy are the low target bioavailability of antitumor drugs and the efflux process. In attempts to overcome this problem, several approaches are proposed here. Firstly, the development of polymeric micellar systems based on chitosan grafted by fatty acids (different types to optimize their properties), which, on the one hand, increase the solubility and bioavailability of cytostatics and, on the other hand, effectively interact with tumor cells due to the polycationic properties of chitosan, allowing for more effective penetration

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Guzmán Rodríguez, Andy Guzmán, Marquiza Sablón Sablón Carrazana, Chrislayne Rodríguez Rodríguez Tanty, Martijn J. A. Malessy, Gastón Fuentes, and Luis J. Cruz. "Smart Polymeric Micelles for Anticancer Hydrophobic Drugs." Cancers 15, no. 1 (2022): 4. http://dx.doi.org/10.3390/cancers15010004.

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Cancer has become one of the deadliest diseases in our society. Surgery accompanied by subsequent chemotherapy is the treatment most used to prolong or save the patient’s life. Still, it carries secondary risks such as infections and thrombosis and causes cytotoxic effects in healthy tissues. Using nanocarriers such as smart polymer micelles is a promising alternative to avoid or minimize these problems. These nanostructured systems will be able to encapsulate hydrophilic and hydrophobic drugs through modified copolymers with various functional groups such as carboxyls, amines, hydroxyls, etc.

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Husseini, Ghaleb A., and William G. Pitt. "The Use of Ultrasound and Micelles in Cancer Treatment." Journal of Nanoscience and Nanotechnology 8, no. 5 (2008): 2205–15. http://dx.doi.org/10.1166/jnn.2008.225.

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The high toxicity of potent chemotherapeutic drugs like Doxorubicin (Dox) limits the therapeutic window in which they can be applied. This window can be expanded by controlling the drug delivery in both space and time such that non-targeted tissues are not adversely affected. Recent research has shown that ultrasound (US) can be used to control the release of Dox and other hydrophobic drugs from polymeric micelles in both time and space. It has also been shown using an in vivo rat tumor model that Dox activity can be enhanced by ultrasound in one region, while in an adjacent region there is li

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Xu, Jing, Jingmou Yu, Xiao Xu, et al. "Development, Characterization, and Evaluation of PSMA-Targeted Glycol Chitosan Micelles for Prostate Cancer Therapy." Journal of Nanomaterials 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/462356.

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Prostate cancer-binding peptides- (PCP-) modified polymeric micelles were prepared and used for the treatment of prostate-specific membrane antigen- (PSMA-) expressing prostate cancer in a target-specific manner. Cholesterol-modified glycol chitosan (CHGC) was synthesized. PCP-conjugated CHGC (PCP-CHGC) micelles were fabricated and characterized. The degree of substitution was 5.2 PCP groups and 5.8 cholesterol groups per 100 sugar residues of glycol chitosan. The critical aggregation concentration (CAC) of PCP-CHGC copolymer was 0.0254 mg/mL. Doxorubicin (DOX) was chosen as a model antitumor

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Aji Alex, M. R., Srivani Veeranarayanan, Aby Cheruvathoor Poulose, Chetan Nehate, D. Sakthi Kumar, and Veena Koul. "Click modified amphiphilic graft copolymeric micelles of poly(styrene-alt-maleic anhydride) for combinatorial delivery of doxorubicin and plk-1 siRNA in cancer therapy." Journal of Materials Chemistry B 4, no. 45 (2016): 7303–13. http://dx.doi.org/10.1039/c6tb02094a.

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Gutiérrez-Saucedo, Ramón A., Julio C. Gómez-López, Adrián A. Villanueva-Briseño, et al. "Pluronic F127 and P104 Polymeric Micelles as Efficient Nanocarriers for Loading and Release of Single and Dual Antineoplastic Drugs." Polymers 15, no. 10 (2023): 2249. http://dx.doi.org/10.3390/polym15102249.

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The potential application of biodegradable and biocompatible polymeric micelles formed by Pluronic F127 and P104 as nanocarriers of the antineoplastic drugs docetaxel (DOCE) and doxorubicin (DOXO) is presented in this work. The release profile was carried out under sink conditions at 37 °C and analyzed using the Higuchi, Korsmeyer–Peppas, and Peppas–Sahlin diffusion models. The cell viability of HeLa cells was evaluated using the proliferation cell counting kit CCK-8 assay. The formed polymeric micelles solubilized significant amounts of DOCE and DOXO, and released them in a sustained manner f

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Duan, Zhongyu, Yu-Juan Gao, Zeng-Ying Qiao та ін. "A photoacoustic approach for monitoring the drug release of pH-sensitive poly(β-amino ester)s". J. Mater. Chem. B 2, № 37 (2014): 6271–82. http://dx.doi.org/10.1039/c4tb00319e.

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In this work, we prepared PEG modified poly(β-amino ester) graft copolymers with pH-sensitive properties. Doxorubicin (DOX) and squaraine (SQ) dye as a photoacoustic tomography (PAT) reporter molecule were loaded into the hydrophobic core of polymeric micelles, and their release profiles investigated using the PAT technique.

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Liu, Jia, Juan Li, and Tingting Liu. "Fabrication of Mixed Polymeric Micelles Based on Stimuli-Responsive Amphiphilic Copolymers for Drug Delivery and Controlled Release." Nano 15, no. 03 (2020): 2050040. http://dx.doi.org/10.1142/s179329202050040x.

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In this report, mixed polymeric micelles (MPMs) system self-assembled from two kinds of cholesterol-grafted amphiphilic block copolymers cholesterol modified poly ([Formula: see text]-amino esters)-grafted disulfide poly (ethylene glycol) methyl ether (PAE(-ss-mPEG)-[Formula: see text]-Chol) and poly([Formula: see text]-amino ester)-g-poly(ethylene glycol) methyl ether-cholesterol (PAE-[Formula: see text]-mPEG-Chol) were prepared for drug delivery and controlled release with pH and redox-responsibilities. The self-assembly of two block copolymers was evaluated by measurement of critical micell

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Wan, Dong, Yujun Liu, Xinhao Guo, Jianxin Zhang, and Jie Pan. "Intelligent Drug Delivery by Peptide-Based Dual-Function Micelles." International Journal of Molecular Sciences 23, no. 17 (2022): 9698. http://dx.doi.org/10.3390/ijms23179698.

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To endow the polymeric prodrug with smart properties through a safe and simple method, matrix metalloproteinase (MMPs) responsive peptide GPLGVRGDG was introduced into the block copolymer to prepare TPGS3350-GPLGVRGDG-DOX&DOX micelles, where TPGS3350 is D-α-tocopheryl polyethylene glycol 3350 succinate. During the doxorubicin delivery, the cleavage of the peptide chain triggers de-PEGylation, and the remaining VRGDG sequence was retained on the surface of the micelles, which can act as a ligand to facilitate cell uptake. Moreover, the cytotoxicity of TPGS3350-GPLGVRGDG-DOX&DOX micelles

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Song, Fei, Zhidan Wang, Wenli Gao, Yu Fu, Qingrong Wu, and Shouxin Liu. "Novel Temperature/Reduction Dual-Stimulus Responsive Triblock Copolymer [P(MEO2MA-co- OEGMA)-b-PLLA-SS-PLLA-b-P(MEO2MA-co-OEGMA)] via a Combination of ROP and ATRP: Synthesis, Characterization and Application of Self-Assembled Micelles." Polymers 12, no. 11 (2020): 2482. http://dx.doi.org/10.3390/polym12112482.

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Novel temperature/reduction dual stimulus-responsive triblock copolymers, poly [2-(2-methoxyethoxy) ethyl methacrylate-co-oligo (ethylene glycol) methacrylate]-b-(L-polylactic acid)-SS-b-(L-polylactic acid)-b-poly[2-(2-methoxyethoxy) ethyl methacrylate-co-oligo(ethylene glycol)methacrylate] [P(MEO2MA-co-OEGMA)-b-PLLA-SS-PLLA-b-P(MEO2MA-co-OEGMA)] (SPMO), were synthesized by ring opening polymerization (ROP) of L-lactide and 2,2’-dithio diethanol (SS-DOH), and random copolymerization of MEO2MA and OEGMA monomers via atom transfer radical polymerization (ATRP) technology. The chemical structures

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Wang, Zhao, Xinyu Guo, Lingyun Hao, Xiaojuan Zhang, Qing Lin, and Ruilong Sheng. "Charge-Convertible and Reduction-Sensitive Cholesterol-Containing Amphiphilic Copolymers for Improved Doxorubicin Delivery." Materials 15, no. 18 (2022): 6476. http://dx.doi.org/10.3390/ma15186476.

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For achieving successful chemotherapy against cancer, designing biocompatible drug delivery systems (DDSs) with long circulation times, high cellular endocytosis efficiency, and targeted drug release is of upmost importance. Herein, a well-defined PEG-b-P(MASSChol-co-MANBoc) block copolymer bearing redox-sensitive cholesteryl-side group was prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization (with non-redox PEG-b-P(MACCChol-co-MAN-DCA) as the reference), and 1,2-dicarboxylic-cyclohexene acid (DCA) was then grafted onto the hydrophobic block to endow it with char

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Liu, Huanhuan, Cangxia Li, Dandan Tang, Xiaonan An, Yanfei Guo, and Youliang Zhao. "Multi-responsive graft copolymer micelles comprising acetal and disulfide linkages for stimuli-triggered drug delivery." Journal of Materials Chemistry B 3, no. 19 (2015): 3959–71. http://dx.doi.org/10.1039/c5tb00473j.

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Dual-cleavable polymeric aggregates were efficiently used for thermo-, pH and reduction triggered controlled release of doxorubicin due to the stimuli-dependent topological transformation and reaggregation of copolymer aggregates.

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Kim, Kihong, Chung-Sung Lee, and Kun Na. "Light-controlled reactive oxygen species (ROS)-producible polymeric micelles with simultaneous drug-release triggering and endo/lysosomal escape." Chemical Communications 52, no. 13 (2016): 2839–42. http://dx.doi.org/10.1039/c5cc09239f.

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A doxorubicin (DOX)-loaded and light-induced ROS-producing polymeric micelle (D-LRPM), in which light triggers simultaneous DOX-release and endo/lysosomal escape, produces a powerful, spatiotemporally controllable, therapeutic efficacy for tumor treatment.

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40

Gao, Di, and Pui-Chi Lo. "Combined pH-responsive chemotherapy and glutathione-triggered photosensitization to overcome drug-resistant hepatocellular carcinoma — a SPP/JPP Young Investigator Award paper." Journal of Porphyrins and Phthalocyanines 24, no. 11n12 (2020): 1387–401. http://dx.doi.org/10.1142/s1088424620500212.

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Doxorubicin (DOX) resistance, which results in a reduced accumulation of DOX in the nucleus and hence decreased DNA damage, is a major challenge for chemotherapy against hepatocellular carcinoma. In this paper, we combined chemotherapy with photodynamic therapy (PDT) to combat DOX-resistant human hepatocellular carcinoma cells. We have prepared the polymeric micelles conjugating with DOX and zinc(II) phthalocyanine (ZnPc) through a pH-responsive hydrazone linker and a glutathione (GSH)-responsive disulfide linker, respectively. The polymeric micelles (DOX-ZnPc-micelles) exhibited a spherical s

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Bhadran, Abhi, Himanshu Polara, Godwin K. Babanyinah, Sruthy Baburaj, and Mihaela C. Stefan. "Advances in Doxorubicin Chemotherapy: Emerging Polymeric Nanocarriers for Drug Loading and Delivery." Cancers 17, no. 14 (2025): 2303. https://doi.org/10.3390/cancers17142303.

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Background/Objectives: Effective and targeted delivery of doxorubicin (DOX) remains a significant challenge due to its dose-limiting cardiotoxicity and systemic side effects. Liposomal formulations like Doxil® have improved tumor targeting and reduced toxicity, but issues such as limited stability, poor release control, and insufficient site-specific delivery persist. As a result, there is a growing interest in advanced drug delivery systems, particularly polymeric nanocarriers, which offer biocompatibility, tunable properties, and ease of fabrication. Methods: This review is organized into tw

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Zlotnikov, Igor D., Alexander A. Ezhov, Natalia V. Dobryakova, and Elena V. Kudryashova. "Disulfide Cross-Linked Polymeric Redox-Responsive Nanocarrier Based on Heparin, Chitosan and Lipoic Acid Improved Drug Accumulation, Increased Cytotoxicity and Selectivity to Leukemia Cells by Tumor Targeting via “Aikido” Principle." Gels 10, no. 3 (2024): 157. http://dx.doi.org/10.3390/gels10030157.

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We have developed a micellar formulation of anticancer drugs based on chitosan and heparin grafted with lipoic and oleic acids that can release the cytotoxic cargo (doxorubicin) in response to external stimuli, such as increased glutathione concentration—a hallmark of cancer. Natural polysaccharides (heparin and chitosan) provide the pH sensitivity of the nanocarrier: the release of doxorubicin (Dox) is enhanced in a slightly acidic environment (tumor microenvironment). Fatty acid residues are necessary for the formation of nanoparticles (micelles) and solubilization of cytostatics in a hydrop

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Chueahongthong, Fah, Singkome Tima, Sawitree Chiampanichayakul, et al. "Doxorubicin-Loaded Polymeric Micelles Conjugated with CKR- and EVQ-FLT3 Peptides for Cytotoxicity in Leukemic Stem Cells." Pharmaceutics 14, no. 10 (2022): 2115. http://dx.doi.org/10.3390/pharmaceutics14102115.

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Doxorubicin (Dox) is the standard chemotherapeutic agent for acute myeloblastic leukemia (AML) treatment. However, 40% of Dox-treated AML cases relapsed due to the presence of leukemic stem cells (LSCs). Thus, poloxamer 407 and CKR- and EVQ-FLT3 peptides were used to formulate Dox-micelles (DMs) and DM conjugated with peptides (CKR and EVQ) for improving AML-LSC treatment. Results indicated that DMs with a weight ratio of Dox to P407 of 1:200 had a particle size of 23.3 ± 1.3 nm with a high percentage of Dox entrapment. They were able to prolong drug release and maintain physicochemical stabil

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Fan, Dun, Jingmou Yu, Ruiqiao Yan, et al. "Preparation and Evaluation of Doxorubicin-Loaded Micelles Based on Glycyrrhetinic Acid Modified Gelatin Conjugates for Targeting Hepatocellular Carcinoma." Journal of Nanomaterials 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/8467169.

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Hepatocellular carcinoma (HCC) is one of the most prevalent fatal diseases and the incidence of HCC is increasing worldwide. Polymeric micelles with targeting groups have drawn great attention as carriers for drug delivery in HCC therapy. Herein, novel glycyrrhetinic acid modified gelatin (GA-GEL) conjugates with three substitution degrees were synthesized and characterized. Doxorubicin (DOX) was applied as a model drug. DOX-loaded GA-GEL (DOX/GA-GEL) micelles were prepared by an emulsion-solvent evaporation method. The mean diameters of DOX/GA-GEL micelles were in the range of 195–235 nm. The

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Li, Yunmo. "Preparation of pH-Sensitive Polymeric Nanoparticles for the Targeted Delivery of Doxorubicin with High Drug Capacity." Highlights in Science, Engineering and Technology 45 (April 18, 2023): 384–90. http://dx.doi.org/10.54097/hset.v45i.7583.

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In this study, pH-responsive prodrug nanoparticles PEG-Schiff-doxorubicin (PEG-Schiff-DOX) were designed and synthesised using chemical conjugation method and can self-assembly into spherical micelles in aqueous solution. These nanoparticles show good storage stability which can be stored over one week under normal condition. The acid-liable Schiff linker is stable under neutral pH and cleave under acidic environment, allowing the prodrug micelles to withhold DOX anticancer drug when being delivered in human circulation and disassemble to release drug once enter tumor cell tissue or taken into

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Liu, Jie, Jinlin He, Mingzu Zhang, Guoqiang Xu, and Peihong Ni. "A synergistic polyphosphoester-based co-delivery system of the anticancer drug doxorubicin and the tumor suppressor gene p53 for lung cancer therapy." Journal of Materials Chemistry B 6, no. 20 (2018): 3262–73. http://dx.doi.org/10.1039/c8tb00746b.

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Kunitskaya, L., and T. Zheltonozhskaya. "BEHAVIOR OF ACID HYDROLYSIS IN BLOCK COPOLYMERS COMPRISING POLYACRYLAMIDE AND POLY(ETHYLENE OXIDE)." Bulletin of Taras Shevchenko National University of Kyiv. Chemistry, no. 1(55) (2018): 60–63. http://dx.doi.org/10.17721/1728-2209.2018.1(55).15.

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Polymeric micelles self-assembled from amphiphilic block copolymers have been intensively investigated as nano-carrier systems for tumor-targeted drug delivery. Diblock copolymers PEO-b-PAAm (DBC) and thriblock copolymers PAAm-b-PEO-b-PAAm (TBC) contained biocompatible chemically complementary polyacrylamide and poly(ethylene oxide) formed micellar structures in aqueous solutions which have hydrophobic complex “core” formed by the hydrogen-bonded PEO/PAAm chains and hydrophilic “corona” of the surplus segments of PAAm blocks. The ability of DBCs and TBCs to bind the anticancer drug doxorubicin

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Debele, Tilahun Ayane, Kuan-Yi Lee, Ning-Yu Hsu та ін. "A pH sensitive polymeric micelle for co-delivery of doxorubicin and α-TOS for colon cancer therapy". Journal of Materials Chemistry B 5, № 29 (2017): 5870–80. http://dx.doi.org/10.1039/c7tb01031a.

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Gu, Li, Ning Wang, Leora M. Nusblat, Rose Soskind, Charles M. Roth, and Kathryn E. Uhrich. "pH-responsive amphiphilic macromolecular carrier for doxorubicin delivery." Journal of Bioactive and Compatible Polymers 32, no. 1 (2016): 3–16. http://dx.doi.org/10.1177/0883911516643219.

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In this work, pH-sensitive amphiphilic macromolecules are designed to possess good biocompatibility and drug loading while employing an acid-sensitive linkage to trigger drug release at tumor tissues. Specifically, two pH-sensitive amphiphilic macromolecules were synthesized with a hydrazone linkage between the hydrophobic and hydrophilic segments. The chemical structure, molecular weight, critical micelle concentration, micelle size, and pH-triggered cleavage of the amphiphilic macromolecules were characterized via matrix-assisted laser desorption/ionization time-of-flight, nuclear magnetic r

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Chung, Tze-Wen, Der-Zen Liu, Jui-Hsiang Hsieh, Xian-Chan Fan, Jean-Dean Yang та Jui-Hsiang Chen. "Characterizing Poly(ε-caprolactone)-b-Chitooligosaccharide-b-Poly(ethylene glycol) (PCP) Copolymer Micelles for Doxorubicin (DOX) Delivery: Effects of Crosslinked of Amine Groups". Journal of Nanoscience and Nanotechnology 6, № 9 (2006): 2902–11. http://dx.doi.org/10.1166/jnn.2006.450.

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New amine-groups containing tri-block copolymers and micelles that consisting of poly(ε-caprolactone)-b-chitooligosaccharide-b-poly(ethylene glycol) (PCL-b-COS-b-PEG, PCP), were synthesized, characterized, and evaluated for delivering doxorubicin (DOX) with or without crosslinked amine groups by genipin. The characteristics of the PCP copolymers of Fourier-transform infrared spectrometry (FT-IR) verify the amine and ester groups of the COS and the PCL of the copolymers, respectively. 1H nuclear magnetic resonance (1H NMR) spectra verify the structures of the PCP copolymers consisting two PCL a

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