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Relevant bibliographies by topics / Polymorphic variation / Dissertations / Theses

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Dissertations / Theses on the topic 'Polymorphic variation'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Hamzeiy, Hossein. "Identification and functional analysis of inherited variation in the CYP3A4 gene regulatory region." Thesis, University of Surrey, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248064.

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2

Sandberg, Lundblad Mia. "Interindividual variation in drug metabolism with focus on polymorphic cytochrome P450 2C9 /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-740-427-9/.

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3

Gíslason, Davíd. "Genetic and morphological variation in polymorphic Arctic charr, Salvelinus alpinus, from Icelandic lakes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ33225.pdf.

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4

Fenech, Anthony. "Polymorphic variation and transcriptional regulation of muscarinic receptor genes in human airway cells." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289500.

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Muscarinic M2 and M3 receptors are important for the development of airway hyperresponsiveness in asthma. While there is currently no evidence to suggest altered function of M3 receptors in airway disease, a dysfunctionality of M2 receptors has been reported to occur in asthmatic patients. Current studies suggest that this dysfunctionality may be caused by allosteric modulation induced by endogenous mediators released by pro-inflammatory cells in inflamed airways. However, it is not known whether genetic variation in the coding or transcriptional regulatory regions of the gene contributes to t

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5

Allnutt, Theodore Richard. "The study of genetic variation in trees using the random amplified polymorphic DNA (RAPD) technique." Thesis, Liverpool John Moores University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319848.

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6

Horton, Brent. "Corticosterone and Morph-Specific Variation in the Reproductive Behavior of the Polymorphic White-Throated Sparrow (Zonotrichia albicollis)." Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/HortonBM2007.pdf.

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7

Gregg, Robert. "An auditory event related potential study investigating the influence of polymorphic variation on population differences in information processing." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534734.

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8

Ghosh, Rajlakshmi. "Assessment of genetic variation and population differentiation in invasive multiflora rose, Rosa multiflora Thunberg (Rosaceae) in northeastern Ohio." Kent State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=kent1247851008.

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9

Yardin, Marie Roseline, of Western Sydney Hawkesbury University, Faculty of Science and Technology, and School of Science. "Genetic variation in Anadara trapezia (Sydney cockle) : implications for the recruitment of marine organisms." THESIS_FST_SS_Yardin_M.xml, 1997. http://handle.uws.edu.au:8081/1959.7/56.

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This project investigated the genetic composition of natural populations of Anadara trapezia in Australia at three spatial scales : i) microgeographic (within an estuary, 50 metres to ~ 6 kilometres); ii) microgeographic (within populations, less than 50 metres); and, iii) macrogeographic (hundreds of kilometres along the coast of Australia). Allozyme polymorphism surveys using cellulose acetate strips have revealed, from 43 enzymes screened, 18 putative polymorphic loci. Comparisons of levels of heterozygosity among enzyme structural groups showed no significant differences, however, monomers

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10

Arendse, Lauren Beth. "Exploring the effects of polymorphic variation on the stability and function of human cytochrome P450 enzymes in silico and in vitro." Doctoral thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/12711.

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Includes bibliographical references.<br>Cytochrome P450s are highly polymorphic enzymes responsible for the Phase I metabolism of over 80% of pharmaceutical drugs. Polymorphic variation can result in altered drug efficacy as well as adverse drug reactions so the lack of understanding of the effects of single amino acid substitutions on cytochrome P450 drug metabolism is a major problem for drug development. In order to begin to address this problem, this thesis describes an in silico analysis of over 300 nonsynonymous single nucleotide polymorphisms found across nine of the major human drug me

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11

Nishihara, Mitsuhiro. "Investigation of Drug Metabolism by Non-Cytochrome P450 Enzymes and Its Clinical Relevance." Kyoto University, 2014. http://hdl.handle.net/2433/189328.

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12

Ivgin, Tunca Rahsan. "Determination And Comparison Of Genetic Variation In Honey Bee (apis Mellifera L.)populations Of Turkey By Random Amplified Polymorphic Dna And Microsatellite Analyses." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12610443/index.pdf.

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We analyzed a total of 760 worker bees, two samples per colony, 390 colonies in 26 provinces in Turkey to determine and compare the genetic variation of Turkish honey bee (Apis mellifera L.) populations using 10 primers for RAPD and 6 microsatellite loci. Mean gene diversity levels ranged from 0.035 (Sanliurfa) to 0.175 (Antalya) for RAPD and 0.449 (Mugla) to 0.739 (Artvin) for microsatellite markers. Private band patterns and alleles, pairwise FST values support that the Anatolian honey bees belong to C lineage except for Hatay and Sanliurfa populations illustrated from previous findings of m

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13

Laubscher, Andrea M. "Polymorphic Variation of the DGAT1 Gene in Cal Poly Holstein and Jersey Breeds and the Correlation of Milk Fat Content, and Genetic Values." DigitalCommons@CalPoly, 2011. https://digitalcommons.calpoly.edu/theses/661.

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The selection of dairy cattle is dictated by improvement of yield and composition of milk. Genotyping tests give breeders the opportunity to use previously unavailable information to increase the frequency of beneficial alleles in their herds. A QTL influencing milk yield and composition is located in the centromeric end of chromosome 14. The polymorphism being analyzed is a K232A substitution (lysine to alanine amino acid change) in exon VII of the diacylglycerol acyl transferase 1 (DGAT1) gene. DGAT1 is a key acyltranferase in triglyceride biosynthesis. DGAT1 encodes an enzyme which cat

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14

Corniquel, Béatrice. "Construction de banques d'ADNc de palmier dattier (Phoenix dactylifera L. ). Différenciation de cultivars par RFLP à l'aide des ADNc : isolement et caractérisation d'un ADNc polymorphe. Isolement et caractérisation d'un ADNc codant pour la glutamine synthetase cytosolique." Angers, 1994. http://www.theses.fr/1994ANGE0014.

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La caractérisation des cultivars de palmier dattier a été réalisée par des analyses RFLP et RAPD à partir des feuilles internes des rejets. Des sondes ont été isolées d'une banque d’ADNc construite à partir d'ARNM extraits de cals organogènes du cultivar bou sthammi noire. La sonde ADNc 1 a permis d'obtenir neuf profils d'hybridation distincts pour chacun des neuf cultivars étudiés. Des profils d'amplification distincts pour trois cultivars ont été obtenus par RAPD avec des amorces oligonucléotidiques. Des analyses RFLP ont été aussi réalisées sur du matériel maintenu in vitro ou issu de cultu

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15

Davidson, Scott. "Investigating human polymorphism density and transcriptional regulation of the galanin gene." Thesis, University of Aberdeen, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=100111.

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The present study aimed to gain better insights into the distribution of genomic variation, in the form of single nucleotide polymorphisms, within the human genome. Using set theory, the average SNP density of the human genome was found to be 2.6 SNPs per kilobase. This figure decreased with increasing evolutionary depth, i.e. conservation. The conserved exonic, intronic subsets had a lower SNP density than the conserved intergenic subset, suggesting that the conserved exonic and intronic regions are under similar strengths of selective pressure while conserved intergenic regions are under

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16

Adrian, Andrew B. "Fine scale recombination variation in Drosophila melanogaster." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/2175.

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The study of natural variation is a principle component of biology. One process that affects levels of natural variation is meiotic recombination—the process by which homologous chromosomes break and interchange genetic information with one another during the formation of gametes. Surprisingly, this factor that shapes levels of natural variation across the genome itself presents with a great deal of variation. That variation manifests itself at many levels: within genomes, between individual organisms, across populations, and among species. The factors and mechanisms responsible for the non-ra

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17

Quadri, Asima. "Assessment of genetic diversity in Asarum canadense L. using amplified fragment length polymorphism (AFLP)." Virtual Press, 2007. http://liblink.bsu.edu/uhtbin/catkey/1371851.

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Forest fragmentation poses a serious danger to population diversity in plants and animals by increasing species isolation, thus reducing the population size and genetic diversity. However, little information is available concerning how fragmentation impacts plant diversity. AFLP fingerprinting was used to assess genetic diversity within and between populations of Asarum canadense L. (Canadian Wild Ginger) across 11 different populations in East-Central Indiana. AFLP fingerprints using two primer pairs generated 51 distinct bands with an average of 25.5 bands per primer. Forty-eight low molecul

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18

Charinthon, Ngamamonpirat Jitra Waikagul. "Sequence variation of Gnathostoma spinigerum mitochondrial DNA by single-strand conformation polymorphism analysis /." Abstract, 2003. http://mulinet3.li.mahidol.ac.th/thesis/2546/46E-Charinthon-N.pdf.

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19

Wennersten, Lena. "Population-level consequences of variation." Doctoral thesis, Linnéuniversitetet, Institutionen för naturvetenskap, NV, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-32522.

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Consequences of within population variation have recently attracted an increased interest in evolutionary ecology research. Theoretical models suggest important population-level consequences, but many of these predictions still remain to be tested. These issues are important for a deepened understanding of population performances and persistence, especially in a world characterized by rapid fragmentation of natural habitats and other environmental changes. I review theoretical models of consequences from intra population genetic and phenotypic variation. I find that more variable populations a

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20

Fredman, David. "Computational exploration of human genome variation /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-025-7/.

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21

Varney, Robin Lynne. "Assessment of nuclear DNA variation and population structure in the eastern oyster, Crassostrea virginica, through discovery and analysis of single nucleotide polymorphisms (SNPs)." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 216 p, 2009. http://proquest.umi.com/pqdweb?did=1891582831&sid=1&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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22

XUE, BIN. "META ANALYSIS OF THE ASSOCIATION OF p53 CODON 72 VARIATION AND CERVICAL CANCER." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1108234287.

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23

Synnergren, Jane. "Wheat variety identification using genetic variations." Thesis, University of Skövde, Department of Computer Science, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-821.

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<p>There is a continuous development of different crop varieties in the crop trade. The cultivated crops tend to be more and more alike which require an effective method for crop identification. Crop type and crop type purity has become a quality measure in crop trade both nationally and internationally. A number of well known quality attributes of interest in the crop trade can be correlated to the specific crop type and therefore it is of great importance to reliably be able to identify different crop varieties. It is well known from the literature that there exist genomic variations at the

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24

Murphy, Lisa. "Variations in immune response as determined by MHC class 1 polymorphism in cattle." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/29901.

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In this study we examined bovine MHC class I genes using both molecular and cellular approaches. There is evidence for the existence of five or six classical class I loci in cattle, with the number of genes expressed varying between haplotypes. Most alleles are putatively assigned to a locus according to their grouping following phylogenetic analysis. Here we applied reference strand mediated conformational analysis (RSCA), a high resolution typing method, to four of these groups: 1, 2, 3 and 6. Using group-specific primers and two reference strands 22 potential new alleles were identified wi

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25

Hollox, Edward John. "Molecular and population genetic analyses of variation within and surrounding the human lactase gene." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322742.

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26

Ramanankandrasana-Randrianarivo, Bienvenue Michèle. "Variation intraspécifique de Taenia solium : analyse génétique par Random Amplified Polymorphie DNA, relation avec la répartition géographique." Limoges, 2003. http://aurore.unilim.fr/theses/nxfile/default/66682872-8814-459f-b979-ddb7cbfc018d/blobholder:0/2003LIMO310A.pdf.

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Tænia solium est un ver parasite de l'homme dont la larve, connue sous le nom de Cysticercus cellulosae, est responsable de cysticercose, maladie très fréquente dans les pays en voie de développement. La cysticercose humaine constitue un grave problème de Santé Publique dans les pays d'Afrique, d'Asie et d'Amérique Latine. Dans les pays d'Afrique et d'Asie, la cysticercose apparaît sous la forme neurologique aussi bien que sous la forme extra neurologique ; alors qu'en Amérique Latine, seules les formes neurologiques sont décrites. La neurocysticercose présente des manifestations cliniques var

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27

Shavorskaya, Oksana. "Identification of genes affecting flowering time variation in Brassica species /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish Univ. of Agricultural Sciences, 2004. http://epsilon.slu.se/a453.pdf.

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28

Trotter, Meridith V., and n/a. "Frequency-dependent selection and the maintenance of genetic variation." University of Otago. Department of Zoology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081114.120926.

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Frequency-dependent selection has long been a popular heuristic explanation for the maintenance of genetic diversity in natural populations. Indeed, a large body of theoretical and empirical work has already gone into elucidating the causes and consequences of frequency-dependent selection. Most theoretical work, to date, has focused either on the diallelic case, or dealt with only very specific forms of frequency-dependence. A general model of the maintenance of multiallelic genetic diversity has been lacking. Here we extend a flexible general model of frequency-dependent selection, the pairw

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29

Auerbach, Scott Sean. "Functional effects of genetic polymorphism and splice variation in human nuclear receptors and their co-activators /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/6307.

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30

Razzaghian, Hamid Reza. "Post-zygotic Genetic Variation in Health and Disease." Doctoral thesis, Uppsala universitet, Medicinsk genetik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196217.

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Post-zygotic genetic variation has previously been shown in healthy individuals and linked to various disorders. The definition of post-zygotic or somatic variation is the existence of genetically distinct populations of cells in a subject derived from a single zygote. Structural changes in the human genome are a major type of inter-individual genetic variation and copy number variation (CNV), involving changes in the copy number of genes, are one of the best studied category of structural genetic changes. In paper I we reported a pair of healthy female monozygotic (MZ) twins discordant for an

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31

Zhao, Mengyao. "Genomic variation detection using dynamic programming methods." Thesis, Boston College, 2014. http://hdl.handle.net/2345/bc-ir:104357.

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Thesis advisor: Gabor T. Marth<br>Background: Due to the rapid development and application of next generation sequencing (NGS) techniques, large amounts of NGS data have become available for genome-related biological research, such as population genetics, evolutionary research, and genome wide association studies. A crucial step of these genome-related studies is the detection of genomic variation between different species and individuals. Current approaches for the detection of genomic variation can be classified into alignment-based variation detection and assembly-based variation detection.

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32

Katzov, Hagit. "Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-787-1/.

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33

Hasmats, Johanna. "Analysis of genetic variations in cancer." Doctoral thesis, KTH, Genteknologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-104438.

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The aim of this thesis is to apply recently developed technologies for genomic variation analyses, and to ensure quality of the generated information for use in preclinical cancer research. Faster access to a patients’ full genomic sequence for a lower cost makes it possible for end users such as clinicians and physicians to gain a more complete understanding of the disease status of a patient and adjust treatment accordingly. Correct biological interpretation is important in this context, and can only be provided through fast and simple access to relevant high quality data. Therefore, we here

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34

Lovmar, Lovisa. "Methods for Analysis of Disease Associated Genomic Sequence Variation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4525.

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35

Kristjansdottir, Gudlaug Thora. "Genetic Variation and Expression of the IRF5 Gene in Autoimmune Diseases." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-99098.

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36

Loh, Yong-Hwee Eddie. "Genetic variation in fast-evolving East African cichlid fishes: an evolutionary perspective." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41148.

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Cichlid fishes from the East African Rift lakes Victoria, Tanganyika and Malawi represent a preeminent example of replicated and rapid evolutionary radiation. In this single natural system, numerous morphological (eg. jaw and tooth shape, color patterns, visual sensitivity), behavioral (eg. bower-building) and physiological (eg. development, neural patterning) phenotypes have emerged, much akin to a mutagenic screen. This dissertation encompasses three studies that seek to decipher the underpinnings of such rapid evolutionary diversification, investigated via the genetic variation in East Afri

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37

Gulduren, Zerrin. "Causes And Consequences Of Seasonal Variation Of Phosphoglucomutase (pgm) Enzyme Polymorphism In Honeybees, (apis Mellifera L.) Of Turkey." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609357/index.pdf.

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Phosphoglucomutase (PGM) is one of the central enzymes in energy metabolism at a branch point at the head of the metabolic pathway leading into glycogen metabolism, pentose shunt and the main glycolytic cycle, catalyzing the reversible interconversion of glucose-1-phosphate to glucose-6-phosphate. Whole year, month to month analysis of pattern of allozyme variation at Pgm and Hk loci in Apis mellifera L. from three provinces<br>Kirklareli, Artvin, and Hatay revealed that there is significant seasonal variation of allozyme frequencies at Pgm locus (P&lt<br>0.001). The difference in genotype

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38

Lindroos, Katarina. "Accessing Genetic Variation by Microarray Technology." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5251-5/.

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39

Yavaş, Gökhan. "Algorithms for Characterizing Structural Variation in Human Genome." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1279345476.

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40

Woodahl, Erica Lynn. "Genetic variation in the multidrug resistance gene (MDRI) : impact on drug delivery and disposition /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/7950.

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41

Ruehl, Clifton Benjamin. "Resource variation and the evolution of phenotypic plasticity in fishes." Thesis, Texas A&M University, 2004. http://hdl.handle.net/1969.1/486.

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Resource variation and species interactions require organisms to respond behaviorally, physiologically, and morphologically within and among generations to compensate for spatial and temporal environmental variation. One successful evolutionary strategy to mitigate environmental variation is phenotypic plasticity: the production of alternative phenotypes in response to environmental variation. Phenotypic plasticity yields multiple characters that may enable organisms to better optimize phenotypic responses across environmental gradients. In this thesis, I trace the development of thought on

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42

Lindström, Sara. "Genetic variation and prostate cancer : population-based association studies in Sweden." Doctoral thesis, Umeå universitet, Strålningsvetenskaper, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1329.

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Prostate cancer constitutes the most common malignancy and the most common cause of cancer‐related death in Swedish men. A large body of evidence suggests that inherited genetic variants contribute to both development and progression of prostate cancer. The aim of this thesis is to identify genetic variants that alter prostate cancer risk and progression. All papers included in this thesis are based on a Swedish population‐based case‐control study (CAPS) comprising 2,965 incident prostate cancer cases and 1,823 controls. In paper I, we investigated if genetic variants in the E‐cadherin gene al

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43

McLarty, Callum. "A pilot study to identify links between genetic variation and shoulder pain and dysfunction after breast cancer radiotherapy." Master's thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/33800.

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Introduction – Treatment for breast cancer is associated with a risk of chronic shoulder and upper limb morbidity in up to 30% of patients. There is currently no consensus for the possible reason for this often repeated finding in the literature. Previous research has suggested that development of fibrotic tissue in response to cancer treatments such as surgery and radiotherapy could be an underlying cause of musculoskeletal dysfunction and pain. This study investigated if any genetic variants in several key fibrosis-modulating genes could be shown to be associated with risk of upper limb musc

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44

Bergman, Olle. "On the influence of dopamine-related genetic variation on dopamine-related disorders /." Göteborg : Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, 2009. http://hdl.handle.net/2077/21077.

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45

Roe, Susan Leslie. "Temporal variation of hydrophobic organochlorine contaminants in the zebra mussel Dreissena polymorpha in relation to physiological and limnological factors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1996. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/MQ30926.pdf.

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46

Olsson, Jens. "Interplay Between Environment and Genes on Morphological Variation in Perch – Implications for Resource Polymorphisms." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7212.

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47

Jian, Zhengwen. "Genetic Diversity and Expression Variation in Human Cytochrome P450 Genes." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1203393700.

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48

Lowe, Robert M. J. "AT-repeat polymorphisms of the human CTLA-4 gene : associations with autoimmune diabetes and allele-specific variation of expression /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/5026.

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49

Yang, Chongqing, and 楊重慶. "Single nucleotide polymorphism in the coding sequence of follicle stimulating hormone receptor and susceptibility to ovarian andendometrial cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31456133.

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50

Hegedus, Miles. "Wing shape variation in the mimetic butterfly Papilio dardanus (Papilionidae) and its unpalatable nymphalid models." ScholarWorks@UNO, 2017. https://scholarworks.uno.edu/td/2410.

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Papilio dardanus displays female-limited polymorphic mimicry of multiple model species. Butterfly wing shape is species-specific and can influence mimetic signaling, but has not been characterized in this species. We used elliptical fourier analysis to investigate whether mimetic P. dardanus female forms have converged on the wing shape of their respective models. Although both models and mimics varied in forewing and hind wing shape, we found no evidence of forewing shape convergence between them. Overall, forewings did not differ in shape between sexes in P. dardanus, nor in four non-mimetic

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