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Dissertations / Theses on the topic 'Polymorphism (genetics)'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Wang, Wei. "Plasminogen polymorphism in dairy cattle." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=26174.

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A genetic approach to lowering protease (plasmin) levels in milk, requires the presence of polymorphism of bovine plasminogen. This study was conducted to determine to what extent genetic polymorphism exists in dairy cattle. Bovine plasminogen was first purified from Holstein cow plasma by affinity chromatography on Lysine-Sepharose and antibodies to bovine plasminogen were raised by monthly intramuscular injection of the isolated bovine plasminogen into rabbits. For plasminogen phenotyping, blood samples were collected at random from 50 Holstein and Ayrshire cattle, and plasminogen was isolat

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2

Bergman, Ingrid-Maria. "Polymorphism in pattern recognition receptor genes in pigs." Doctoral thesis, Linnéuniversitetet, Institutionen för naturvetenskap, NV, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-116.

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The mammalian immune defense consists of two systems, which are interconnected and co-operate to provide host defense. The innate immune system is always active and detects and responds to non-self without delay. The adaptive immune system has a lag phase, but is more specific and has got a memory. The innate immune system relies on pattern recognition receptors (PRRs) to detect molecular patterns signaling microbial presence. This thesis focuses on a centrally placed family of PRRs, namely the Toll-like receptors (TLRs), and on mannan-binding lectin (MBL), a PRR which initiates the lectin act

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3

Sjödin, Per. "Effects of Selection and Demography on DNA Polymorphism in Black Mustard (Brassica nigra)." Doctoral thesis, Uppsala universitet, Evolutionär funktionsgenomik, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6633.

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The evolution of three genes from the CONSTANS-LIKE gene family is studied in Brassica nigra. We use a combination of population genetic and phylogenetic techniques in order to assess the relative importance of selection and demography on the pattern of DNA variation. The analysis is complicated by the fact that they are recent duplicates of each other and hence there is a potential redundancy factor that has to be considered. The relationship between two of the genes, COa and COb, is however much closer than between any relationship to the third gene, COL1. The three genes are all suspected t

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4

Wilkie, Susan Elizabeth. "DNA polymorphism in Allium." Thesis, University of Hertfordshire, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332242.

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5

Mitchell, John Edward. "Structural polymorphism in repeated DNA." Thesis, University of Portsmouth, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306945.

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6

Loh, Yong-Hwee Eddie. "Genetic variation in fast-evolving East African cichlid fishes: an evolutionary perspective." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41148.

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Cichlid fishes from the East African Rift lakes Victoria, Tanganyika and Malawi represent a preeminent example of replicated and rapid evolutionary radiation. In this single natural system, numerous morphological (eg. jaw and tooth shape, color patterns, visual sensitivity), behavioral (eg. bower-building) and physiological (eg. development, neural patterning) phenotypes have emerged, much akin to a mutagenic screen. This dissertation encompasses three studies that seek to decipher the underpinnings of such rapid evolutionary diversification, investigated via the genetic variation in East Afri

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7

Liu, Shuk Ming. "Single nucleotide polymorphism in human microsomal glutathione s-transferase gene and colorectal cancer /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202003%20LIU.

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Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003.<br>Includes bibliographical references (leaves 95-105). Also available in electronic version. Access restricted to campus users.

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8

Jordan, Gabriele. "Polymorphism of normal colour vision in humans." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240178.

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9

Rao, Ravi Madduri. "Defining the functional significance of the E-selectin S128R polymorphism." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271215.

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10

Chen, Pak-lam Sammy, and 陳栢林. "Influence of microsomal triglyceride transfer protein (MTP) gene polymorphism on plasma lipids and lipoproteins in southern Chinese." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31980922.

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11

Hu, Yin. "Genetic polymorphism and regulation of cytochrome P450 2E1 /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3690-0.

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12

Davidson, Scott. "Investigating human polymorphism density and transcriptional regulation of the galanin gene." Thesis, University of Aberdeen, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=100111.

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The present study aimed to gain better insights into the distribution of genomic variation, in the form of single nucleotide polymorphisms, within the human genome. Using set theory, the average SNP density of the human genome was found to be 2.6 SNPs per kilobase. This figure decreased with increasing evolutionary depth, i.e. conservation. The conserved exonic, intronic subsets had a lower SNP density than the conserved intergenic subset, suggesting that the conserved exonic and intronic regions are under similar strengths of selective pressure while conserved intergenic regions are under

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13

Michie, Laura Jane. "Evolution and genetics of colour polymorphism in three ladybird species." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609207.

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14

Olsen, Jeffrey B. "Genetic interpretation of microsatellite polymorphism in Pacific salmon : case studies in population genetics and kinship analysis /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/5285.

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15

McCloskey, Daniel John. "Population genetics of HLA class I-A, -B and -Cw polymorphism." Thesis, Queen Mary, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271337.

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16

Zhang, Hanyuan. "Genetics of plumage colour polymorphism in the Gouldian finch (Erythrura gouldiae)." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/8924/.

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External pigmentation plays an important role in the evolution, ecology and behaviour of birds. However, our understanding of the genetic basis of variation in plumage colouration is as yet very limited, and especially for loci that control carotenoid pigmentation. Therefore, this thesis details the exploration of the molecular genetic basis of head colour polymorphism that occurs in natural populations of the Gouldian finch (Erythrura gouldiae). In order to identify the genomic regions encoding variation in plumage traits, a microsatellite-based genetic linkage map was constructed. There was

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17

Woo, Andrew Jonghan. "Characterization and identification of transcription factors that bind to the tumor necrosis factor -308 polymorphism." University of Western Australia. School of Biomedical and Chemical Sciences, 2003. http://theses.library.uwa.edu.au/adt-WU2004.0044.

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[Formulae and special characters can only be approximated. Please see the pdf version of this abstract for an accurate reproduction.] Tumor necrosis factor (TNF) is a pleiotropic cytokine that mediates a long list of immunological and pathophysiological processes. TNF is produced by a wide variety of cells including immune and non-immune cells, however in most cell types TNF is not expressed prior to stimulation. The function of TNF is mediated via its trimeric domain by binding to TNF receptors that are found on most types of cells, especially of the haematopoietic systems, hence transpiring

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18

Montgomery, Stephen. "On computational strategies for regulatory element and regulatory polymorphism detection." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/58.

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Identification of the mechanisms by which genes are regulated in eukaryotes is one of the principal challenges of modern biology. The emergence of genome sequencing has facilitated the marked expansion of experimental and computational approaches designed to address this challenge. Integrating and assessing this information remains a major scientific endeavor that requires new and innovative application of technology. Furthermore, our limited understanding of the mechanisms of gene regulation in eukaryotes has undermined our ability to understand the role of genetics in gene regulation. R

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19

Hedberg, Jesper. "Function, expression and polymorphism of human alcohol dehydrogenase 3/glutathione-dependent formaldehyde dehydrogenase /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4749-x/.

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20

Sawyer, Sarah Lynn. "Using SNPs to study complex genetic disease : a population and evolutionary genetics perspective /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-967-6/.

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21

Silva, Erica Furquim Soledade Neves. "Polimorfismos dos genes GSTM1 e GSTT1, do sistema da Glutationa S-Transferase, e T6235C e A4889G do gene CYP1A1, do sistema do Citocromo P450, na susceptibilidade ao carcinoma de celulas escamosas de cabeça e pescoço." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290505.

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Orientador: Carmen Silvia Passos Lima<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-10T01:04:22Z (GMT). No. of bitstreams: 1 Silva_EricaFurquimSoledadeNeves_M.pdf: 1247474 bytes, checksum: fb164930ca8036640d7d8a9b9f56bca8 (MD5) Previous issue date: 2007<br>Resumo: As glutationa S-transferases (GSTs) são enzimas detoxificantes que atuam no mecanismo de proteção contra a carcinogênese. Os genes GSTM1 e o GSTT1 são polimórficos em humanos e estão deletados de forma homozigótica em 40-50% e 15-25% dos

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22

Sikström, Carin. "The transferrin polymorphism : population genetics and associations with reproductive hazards and disease." Doctoral thesis, Umeå universitet, Medicinsk och klinisk genetik, 1994. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100565.

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Human serum transferrin (TF) carries iron from the intestine, reticuloendothelial system and liver parenchymal cells to proliferating cells in the body. TF is highly polymorphic, and previous findings of associations between TF types and reproductive hazards in different species suggest that the TF polymorphism may be involved in natural selection and susceptibility to disease. The aims of this thesis were: to examine the TF polymorphism in Finns, Swedes and Swedish Saamis and variations of TF allele frequencies between 23 North-Swedish subpopulations. to study TF types in relation to spontane

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23

McDonald, D. P. "Genetics, physiology and biochemistry of the PGI polymorphism in Asellus aquaticus (L.)." Thesis, University of Essex, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328752.

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24

Wang, Jue. "Regulation and polymorphism of CYP2A6, CYP2B6 and CYP2E1 : functional and clinical aspects /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-650-6/.

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25

Yengi, Lilian Gambo. "Polymorphism at loci encoding detoxifying enzymes : influence on susceptibility to cancer and inflammatory mediated pathologies." Thesis, Staffordshire University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242066.

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26

Hrabik, Sarah A. "The Clinical Utility of a SNP Microarray in Patients with Epilepsy at a Tertiary Medical Center." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368024881.

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27

Silva, Susana Maria Nunes da. "Susceptibilidade genética para cancro da mama." Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2010. http://hdl.handle.net/10362/5552.

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RESUMO: O cancro da mama é a patologia oncológica mais frequente nas mulheres sendo o responsável pela maior taxa de mortalidade por cancro no sexo feminino. Contudo, as causas inerentes a esta patologia permanecem por esclarecer. Nos últimos anos tem-se verificado que o risco para patologia neoplásica depende de factores ambientais e genéticos, estando estes últimos associados à variabilidade genética inter-individual. Polimorfismos genéticos em genes envolvidos no metabolismo de hormonas sexuais, de cancerígenos ambientais e na reparação da lesão genética, são potenciais candidatos a estarem

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28

Wang, Linghang. "Killer immunoglobulin-like receptor polymorphism in a Chinese HIV-1 infection cohort." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:9c1d0fb9-21b0-4123-995d-6bd5ae3e094f.

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Genetic and functional studies have demonstrated that KIR gene polymorphism, including different haplotypes, allelic polymorphisms and different expression levels of KIRs, may all play a part in the association with HIV-1 infection outcome. Currently, there are very few studies focusing on the association between KIR and HIV in the Chinese population. In this project, we started to look at the polymorphism of KIRs in a unique chronic HIV-1 infected cohort (SM cohort), evaluating the impact of KIR and KIR-HLA interactions in terms of HIV-1 infection progression. The SM cohort is unique because

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29

Raunio, T. (Taina). "Gene polymorphism and systemic inflammatory response in chronic periodontitis." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514292361.

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Abstract In this study, associations between periodontitis expression, serum levels of inflammatory markers and genetic factors were investigated. The periodontal status of 56 subjects with chronic periodontitis, 28 control subjects and 80 subjects with type I diabetes mellitus (DM) was examined. In addition, a reference group (n=178) with genetic but not with periodontal health data was included. The single nucleotide polymorphisms of CD14 -260, IL-6 -174, TNF-α -308, IL-10 -1082, IL-1A -889, IL-1B +3954, and TLR4 +896 were determined using PCR with RFLP or allele-specific primers, and compar

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30

Ajuria, Ibarra Helena. "Maintenance of a female-limited colour polymorphism in the crab spider Synema globosum (Araneae: Thomisidae)." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13186/.

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The occurrence of multiple genetically and phenotypically distinct forms in a single interbreeding population, known as polymorphism, represents a long-standing puzzle in evolutionary biology. Several mechanisms, both selective and stochastic, have been proposed to account for the maintenance of such diversity. Nevertheless, although our knowledge about how these mechanisms might operate has increased substantially in recent years, the specific role that they play in the maintenance of polymorphisms in natural populations remains to be determined. In particular, negative frequency-dependent se

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31

Gerber, Jaclyn. "Cytochrome P450 polymorphisms : relevance in two South African disease populations." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53345.

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Thesis (MSc)--Stellenbosch University, 2003.<br>ENGLISH ABSTRACT: With knowledge of the human genome increasing constantly we are continually faced with new and potentially groundbreaking methods for managing, treating and/or identifying diseases and predisposition to diseases and conditions at a genetic level. The human cytochrome P450 (CYP) super-family of genes code for enzymes that can participate in metabolism of drugs and foreign chemicals and in steroid synthesis and metabolism. Mutations in these genes may contribute to clinically relevant diseases. In this study, the effects of

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32

Sjödin, Per. "Effects of selection and demography on DNA polymorphism in black mustard (Brassica nigra) /." Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6633.

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33

Yang, Chongqing. "Single nucleotide polymorphism in the coding sequence of follicle stimulating hormone receptor and susceptibility to ovarian and endometrial cancer." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31456133.

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34

Fitzsimmons, Carolyn. "Exploring the Realm of Gene Expression Differences Between White Leghorn and Red Junglefowl Chickens." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6273.

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35

Fainman, Joshua. "The promoter of the vervet serotonin transporter gene : sequencing and association of a novel polymorphism with anxiety." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80259.

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The serotonin transporter has long been implicated as a key modulator of mood, with deficits of central nervous system serotonin implicated in many psychiatric disorders (anxiety, depression, alcoholism, etc.). The serotonin transporter is responsible for the high-affinity reuptake of serotonin from the synapse, effectively terminating the potentiation of the serotonergic signal. The objectives of this work were to sequence the serotonin transporter promoter region in the vervet monkey (C. aethiops), identify polymorphisms and determine whether they were associated with any of the previ

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36

Bentzen, Paul. "Mitochondrial DNA polymorphism in American shad (Alosa sapidissima) and its implications for population structure." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75964.

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Analysis of mitochondrial DNA (mtDNA) sequence variation among 244 American shad (Alosa sapidissima) from 14 rivers spanning the (Florida-Quebec) range of the species revealed several unusual features of shad mtDNA polymorphism. Two types of heteroplasmy, one involving a length polymorphism and the other a restriction site are common in shad. The length polymorphism involves a novel tandem triplication of a 1.5-kb sequence in the D-loop region. Both forms of heteroplasmy stem from multiple mutational events. The mtDNA data indicate that shad populations are reproductively discrete, and suggest

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37

Kaiser, Liselotte. "Molecular characterisation of major allergens from mite (Lep d 2) and cat (Fel d 1) /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-859-9.

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38

Ruppelt, Theresa. "Single nucleotide polymorphism array analysis in copy number variant detection: assessment of its feasibility in the diagnostic setting." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/23720.

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Intellectual disability/developmental delay (ID/DD) is a significant problem in child health affecting 2 to 3% of the population worldwide. While the underlying aetiology of ID/DD in a large proportion (about 50%) of these patients is unknown, 15 to 20% of the internationally reported cases detected using microarray technologies are due to copy number variants (CNVs), whereas only 3 to 5% of ID/DD can be identified with conventional cytogenetics. The Affymetrix® Cytoscan™ High Density (HD) Array (Affymetrix, Santa Clara, CA) containing over 2.4 million markers for copy number (CN) was used to

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39

Yang, Chongqing, and 楊重慶. "Single nucleotide polymorphism in the coding sequence of follicle stimulating hormone receptor and susceptibility to ovarian andendometrial cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31456133.

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40

Dilek, Derya. "Relationship Between The Nat Genetic Polymorphism And Susceptibility To Prostate Cancer." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/2/12609777/index.pdf.

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Prostate cancer (PCa) is one of the most prevelant cancers in males in many countries, increasing in frequency with age. PCa incidence and mortality rates are not evenly distributed worldwide. Family history is an established risk factor for prostate cancer and families demonstrating autosomal dominant or X-linked transmission of susceptibility have been observed. Although an increasing number of candidate genes or hereditary prostate cancer susceptibility have been identified, only 5 to 10 percent of prostate cancer cases in the population may arise from major susceptibility genes. A few risk

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41

Somridhivej, Benjaporn Liu Zhanjiang. "Characterization, polymorphism assessment, and database construction for microsatellites from BAC end sequences of catfish a resource for integration of linkage and physical maps /." Auburn, Ala., 2007. http://repo.lib.auburn.edu/Send%2011-10-07/SOMRIDHIVEJ_BENJAPORN_30.pdf.

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42

Mercer, Heather Milliken. "The Distribution of Single Nucleotide Polymorphisms in Pyoderma Gangrenosum: Biomarker Discovery." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1383769612.

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43

Ferezin, Letícia Perticarrara. "Associação de polimorfismos genéticos com parametros de saúde em mulheres a partir de 50 anos de idade." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/22/22132/tde-24012017-162252/.

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O processo de envelhecimento é marcado por diversos estilos de vivências e experiências e traz consigo alterações morfológicas e fisiológicas. Estas mudanças ocorrem devido a componentes celulares e moleculares, os quais são controladas por fatores genéticos e não genéticos. Por isso, é de grande importância investigar sobre as associações existentes entre as alterações genéticas, o envelhecimento e o ambiente para a compreensão das características próprias do processo de envelhecimento. O objetivo foi estudar a associação dos polimorfismos genéticos AKT1 G205T (rs1130214), AGTR1

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Koushik, Anita. "The p53 CODON 72 polymorphism and risk of pre-invasive cervical neoplasia /." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84277.

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Introduction. The Arg/Arg genotype vs. Arg/Pro or Pro/ Pro at codon 72 of the p53 gene has been implicated in increasing susceptibility of the cervix to the action of human papillomaviruses (HPV) and thus altering cancer risk. However, research on this topic has been contentious. Meta-analysis and meta-regression analysis, included as part of this project, revealed that studies where departures from Hardy-Weinberg equilibrium were observed tended to report higher odds ratios (OR). In fact, several methodological and study design choices can contribute to such departures. The primary pur

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45

Lu, Yang 1972. "High throughput study of the translational effect of human single nucleotide polymorphisms." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116089.

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Introduction: As a part of the Gene Regulators in Disease project (GRID), this study aims to create a novel high throughput method to discover the genetic effect on gene translation, taking advantage of the rationale that efficiently translated mRNAs associate with multiple ribosomes, while less active ones with fewer or none.<br>Methods: Lymphoblastoid cell lines (LCLs) from 44 HapMap European individuals were used for polyribosomal fractionation and establishing the sample bank for the future study. The fractionated mRNA samples of 10 out of the 44 individuals were run on an Illumina GoldenG

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46

Yaşar, Ümit. "Cytochrome P450 2C9 polymorphism : interindividual differences in drug metabolism and phenotyping methodology /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-131-4/.

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47

Chakuroff, Carolyn. "The effect of complement factor H Y402H polymorphism on visual outcomes after anti-VEGF treatment of exudative AMD." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543346415979437.

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48

Tanrikut, Cihan. "Dna Repair Genes, Xrcc3 And Rad51, Polymorphisms And Risk Of Childhood Acute Lymphoblastic Leukemia." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612836/index.pdf.

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In this study, the role of two DNA repair genes, X-ray repair cross complementing group 3 (XRCC3) Thr241Met and Rad51 G135C polymorphisms were investigated in the risk of development of childhood ALL in Turkish population among 193 healthy controls and 184 ALL patients, by using PCR-RFLP technique. For XRCC3 Thr241Met polymorphism, the frequencies of both heterozygous and homozygous mutant genotypes were found to be higher in the controls compared to ALL patients (OR: 0.59, p = 0.02<br>OR: 0.48, p = 0.02, respectively). In addition, either heterozygous (Thr/Met) or homozygous mutant (Met/Me

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49

Ledmyr, Helena. "Molecular regulation of microsomal triglyceride transfer protein, MTP : functional genetic studies in relation to cardiovascular disease /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-142-3/.

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50

Southwell, Jason M. "The role of the androgen receptor CAG repeat polymorphism in the AR-T877A prostate cancer somatic mutant /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111933.

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The androgen receptor plays a critical role in both normal and neoplastic prostate growth. The first exon of the androgen receptor contains a polymorphic CAG repeat region that has been implicated in the development of prostate cancer. Epidemiologic studies suggest that shorter CAG repeats are associated with an increased risk of prostate cancer. Interestingly, the length of the CAG repeat region in the androgen receptor is inversely correlated with the transactivational competence of the receptor. This provides a biologically plausible mechanism by which the more active androgen receptors wit

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