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Dissertations / Theses on the topic 'Polymorphism of the TLR4 gene'

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Published: 28 May 2022

Last updated: 30 July 2025

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1

Бевз, Т., Г. Мартинюк, С. Куляс, О. Попович та Л. Медведєва. "Особливості клінічного перебігу та прогнозу хронічного гепатиту С при поліморфізмі гену TLR4". Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/65455.

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Згідно офіційної статистики, в Україні станом на 1 січня 2014 р. близько 3% наслення хворі на ВГС. Приблизно у 85% всіх інфікованих розвивається хронічний гепатит С, що призводить до розвитку цирозу печінки у 20% (протягом 20 років) і гепатоцелюлярної карциноми у 7% пацієнтів. Відсутність специфічної імунопрофілактики; побічні ефекти та стійкість до лікування, яке є високовартісним – все це диктує необхідність пошуку нових шляхів оптимізації діагностики та лікування хворих на хронічний вірусний гепатит С.<br>The clinical investigation discusses the connection between TLR4-polymorphysm

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2

Lundberg, Anna. "Immune responses to lipopolysaccharide in relation to allergic disease : a TLR4 gene polymorphism and endotoxin exposure." Doctoral thesis, Linköpings universitet, Pediatrik, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16783.

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Background: Allergic diseases have increased during the last decades, particularly in affluent countries, possibly due to a reduced and/or altered microbial exposure during infancy. Activation of the immune system by microbes early in life is probably required for accurate maturation of the immune system and tolerance development. It is not fully understood how microbial exposure is associated with the development of allergic diseases, however. Genetic factors may influence microbial induced immune responses. A certain polymorphism, in the gene coding for the Toll-like receptor 4, i.e. (TLR4 A

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3

Бевз, Т., Г. Мартинюк, С. Куляс, О. Попович та Л. Медведєва. "Особливості клінічного перебігу та прогнозу хронічного гепатиту С при поліморфізмі гену TLR4". Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/64380.

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Згідно офіційної статистики, в Україні станом на 1 січня 2014 р. близько 3% наслення хворі на ВГС. Приблизно у 85% всіх інфікованих розвивається хронічний гепатит С, що призводить до розвитку цирозу печінки у 20% (протягом 20 років) і гепатоцелюлярної карциноми у 7% пацієнтів. Відсутність специфічної імунопрофілактики; побічні ефекти та стійкість до лікування, яке є високовартісним – все це диктує необхідність пошуку нових шляхів оптимізації діагностики та лікування хворих на хронічний вірусний гепатит С.<br>The clinical investigation discusses the connection between TLR4-polymorphys

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4

Roldan, Montes Valentina. "Estudo de polimorfismos do gene TLR4 e suas associações com características de importância econômica em búfalas leiteiras /." Jaboticabal, 2016. http://hdl.handle.net/11449/144661.

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Orientador: Humberto Tonhati<br>Coorientador: Gregório Miguel Ferreira de Camargo<br>Coorientador: Naudin Alejandro Hurtado Lugo<br>Banca: Lenira El Faro Zadra<br>Banca: Henrique Nunes de Oliveira<br>Resumo: Considerando a importância das doenças que afetam o desempenho produtivo dos animais na indústria leiteira em todo o mundo é necessário implementar ferramentas moleculares que auxiliem na identificação e controle destas doenças. Quando ocorre alguma infecção em um organismo superior, existe aumento do número de células de defesa e o sistema imune inato proporciona uma linha de defesa contr

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5

Neto, Lídio Gonçalves Lima. "Polimorfismo dos genes CD14, TLR2, TLR4, IL6 e sua associação com o infarto do miocárdio em adultos jovens." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-18022014-101606/.

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O objetivo deste estudo foi avaliar a possível associação entre os polimorfismos -260C/T do gene CD14, Arg753Gln do gene TLR2, Asp299Gli e Thr39911e do gene TLR4 e -174G/C do gene IL6 com o infarto do miocárdio em adultos jovens. Para isso, foi realizado um estudo caso controle, sendo o grupo de estudo constituído por 102 pacientes que tiveram de infarto do miocárdio (34,5 ± 5 anos) e o grupo controle (35,1±8,7 anos) por 108 indivíduos sem histórico de doenças cardiovasculares. A genotipagem foi realizada pela PCRRFLP. Houve ausência de associação entre a distribuição dos genótipos dos SNPs -2

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6

Prioli, Renato Alves [UNESP]. "Caracterização da variabilidade de genes relacionados à fisiologia do sistema imune em equinos da raça mangalarga." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/92578.

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Made available in DSpace on 2014-06-11T19:26:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-02-08Bitstream added on 2014-06-13T19:33:16Z : No. of bitstreams: 1 prioli_ra_me_jabo.pdf: 689132 bytes, checksum: 17eaeca002f2374370af36bb9266bcc4 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Os objetivos deste trabalho foram a padronização de metodologia alternativa de genotipagem do SNP AY_731081:g.1900T>C do gene CD14 equino por PCR-RFLP, bem como a caracterização em equinos da raça Mangalarga deste e de outros dois polimorfismos, o AY_005808: c.1530A>G do T

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7

Pakalnienė, Jolita. "Genų, koduojančių penktą chemokino ir trečią Toll-like receptorius, polimorfizmų reikšmė erkinio encefalito viruso infekcijos metu." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140930_085230-33015.

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Erkinis encefalitas (EE) – pati dažniausia ir sunkiausia virusinė nervų sistemos infekcija Lietuvoje, kuria per metus vidutiniškai suserga 400 žmonių. Užsikrėtus EE virusu (EEV), galima besimptomė arba klinikinius požymius sukelianti ligos eiga, turinti platų požymių spektrą – nuo lengvos, meningitinės ligos formos iki sunkaus encefalito. Nors mirštamumas nuo EE yra nedidelis, svarbiausia problema – ilgai trunkantis sveikimo laikotarpis ir ilgalaikiai liekamieji reiškiniai, kurie būdingi 26–46 proc. persirgusiųjų. Neaišku, kodėl užsikrėtę identiško virulentiškumo virusu, vieni žmonės perserga

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8

Salimu, Josephine. "Tumour antigen cross-presentation from irradiated tumour cells and the role of tlr4 polymorphism." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/64217/.

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Immune responses contribute to the success of radiation therapy of solid tumours; however, the mechanism of triggering CD8+ T cell responses is poorly understood. Antigen cross-presentation from tumour cells by dendritic cells (DC) is a likely dominant mechanism to achieve CD8+ T cell stimulation. We established a cross-presentation model in prostate cancer in which DC present a naturally expressed oncofetal tumour antigen (5T4) from irradiated DU145 tumour cells to 5T4-specific T cells. Ionising radiation (12 Gy) caused G2/M cell cycle arrest and cell death, increased cellular 5T4 and high-mo

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9

Tellier, AureÌlien. "A theory of polymorphism in gene-for-gene interactions." Thesis, University of East Anglia, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439932.

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10

Atan, Deniz. "Cytokine gene polymorphism in non-infectious uveitis." Thesis, University of Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492470.

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Non-infectious uveitis is a blinding intraocular inflammatory disorder with an autoimmune pathogenesis. Like other autoimmune diseases, uveitis has multifactorial and polygenic aetiology. The results of this study have shown that polymorphisms of the ILIO and TNF genes influence the susceptibility and seventy of uveitis. These polymorphisms were either known to correlate with altered transcription levels, or linked with other polymorphisms positioned within regulatory conserved non-coding sequences. Thus the identification of specific genetic variants that confer susceptibility or resistance t

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11

Sankaran, David. "Cytokine gene polymorphism and kidney transplant outcome." Thesis, University of Manchester, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488310.

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The pro-inflammatory cytokine TNF -a. and the immunoregulatory cytokine IL-IO have been implicated in acute rejection of kidney allografts. Similarly, the pro-fibrotic cytokine TGF-IJ 1 has been reported to be involved in the development of chronic rejection. It has also been shown that polymorphisms in the TNFA gene promoter (position -308) and in the TGF-IJI gene (at codon 25) correlate with differential production of these cytokines in vitro. Gene polymorphisms in the IL-IO promoter were also identified previously. However, their function had not been determined. Therefore, the initial part

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12

Pandya, Bhavna Kalpesh. "Thiopurine s-methyl transferase gene polymorphism : Clinical correlations." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529233.

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13

Tomeson, D. "Nucleotide excision repair gene polymorphism and skin cancer." Thesis, University of Edinburgh, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.662988.

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The most important environmental risk factor for skin cancer is sunlight exposure. The genetic component is seen in the inherited genodermatoses, such as Xeroderma Pigmentosum (XP), where there is a 1000-fold increased risk of skin cancer. Nucleotide excision repair (NER), the pathway responsible for removal of UV-induced DNA damage, is defective in XP patients. The XPB and XPD helicases are essential components of the NER pathway. Frequent polymorphisms have been reported in NER genes and polymorphisms in ERCC2, ERCC1 and XPF have been investigated for association with various types of cancer

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14

Moskaliuk, I. I., and O. I. Fediv. "Thyrotoxicosis and irritable bowel syndrome: SERT-gene polymorphism." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17104.

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15

Prioli, Renato Alves. "Caracterização da variabilidade de genes relacionados à fisiologia do sistema imune em equinos da raça mangalarga /." Jaboticabal : [s.n.], 2010. http://hdl.handle.net/11449/92578.

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Resumo: Os objetivos deste trabalho foram a padronização de metodologia alternativa de genotipagem do SNP AY_731081:g.1900T>C do gene CD14 equino por PCR-RFLP, bem como a caracterização em equinos da raça Mangalarga deste e de outros dois polimorfismos, o AY_005808: c.1530A>G do TLR4 e o AX_463789: g.133T>C do Cε, a fim de promover o embasamento necessário para futuras pesquisas visando associação entre marcadores de DNA e características relacionadas à fisiologia do sistema imune na raça. Para tanto, foram utilizados 151 animais Mangalarga, de ambos os sexos e de idades variadas, representati

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16

Maughan, Willard. "The Effect of Single Nucleotide Polymorphisms (SNPs) in Toll-Like Receptors -2, -4, -9, and CD14 Genes in an African-American Population with Chronic Periodontitis." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1844.

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AIM: to determine if a relationship exists between TLR-2, TLR-4, TLR-9, or CD14 polymorphisms and risk for developing chronic periodontal disease in an African-American population. This is the first study conducted to determine role of SNPs in TLR genes and CD14 gene in a periodontally-diseased African-American population. Additionally, this is the first study to assess the role of TLR-9 polymorphism in periodontitis patients. METHODS: A total of 130 subjects were involved in the study. The chronic periodontitis (CP) group contained 73 subjects, and the healthy control (NP) group 57subject

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17

Franchim, Camila Sommerauer [UNIFESP]. "Mediadores de inflamação e pré-eclâmpsia: análise de polimorfismos de genes codificadores de IL1-R1, IL-12, IL-18, TLR-2 e TLR-4." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/9805.

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Made available in DSpace on 2015-07-22T20:50:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-04-29<br>Objetivo: avaliar a possível relação entre polimorfismos dos genes codificadores de receptor 1 de interleucina (IL) 1 (IL-1R1) (PstI, rs2234650), IL-12 (+1188, rs3212227), IL-18 (-137, rs187238), IL-18 (-607, rs1946519), receptor tipo Toll (TLR) 2 (TLR-2) (+2258, rs5743708) e TLR-4 (+896, rs4986790) e a pré-eclâmpsia (PE). Pacientes e métodos: Este estudo de caráter caso-controle incluiu 109 pacientes com PE e 174 gestantes sem patologia sistêmica ou obstétrica, e com história de

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18

Smith, Erin N. "Gene-environment interaction in yeast gene expression /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/5025.

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19

Raunio, T. (Taina). "Gene polymorphism and systemic inflammatory response in chronic periodontitis." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514292361.

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Abstract In this study, associations between periodontitis expression, serum levels of inflammatory markers and genetic factors were investigated. The periodontal status of 56 subjects with chronic periodontitis, 28 control subjects and 80 subjects with type I diabetes mellitus (DM) was examined. In addition, a reference group (n=178) with genetic but not with periodontal health data was included. The single nucleotide polymorphisms of CD14 -260, IL-6 -174, TNF-α -308, IL-10 -1082, IL-1A -889, IL-1B +3954, and TLR4 +896 were determined using PCR with RFLP or allele-specific primers, and compar

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20

Wiener, Christopher Charles. "Intraspecific 16S ribosomal RNA gene polymorphism in Staphylococcus epidermidis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ39895.pdf.

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21

Muhammed, H., Андрій Миколайович Лобода, Андрей Николаевич Лобода, and Andrii Mykolaiovych Loboda. "Gene polymorphism in patients with type 1 diabetes mellitus." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/60769.

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Type 1 diabetes mellitus (T1DM) is a common medical and social problem, which frequency increased during last decade. Annual incidence varies from 0.61 cases per 100,000 population in China to 41.4 cases per 100,000 population in Finland. A general amount ill child in Ukraine in 2016 is approximately 8,500. T1DM is a disease with heterogeneous etiology, influenced by environmental factors and prevalent autoimmune susceptibility. Predisposition of the autoimmune pancreatic β-cell destruction has been associated with genetic variations on different chromosomes.

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Aramini, Beatrice <1979&gt. "Role of SP-A gene polymorphism in lung transplantation." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3634/1/aramini_beatrice_tesi.pdf.

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Lung transplantation is a widely accepted therapeutic option for end stage lung disease. Clinical outcome is yet challenged by primary graft failure responsible for the majority of the early mortality, by chronic allograft dysfunction and chronic rejection accounting for more than 30% of deaths after the third postoperative year. Pulmonary surfactant proteins (SP) A, B, C and D are one of the first host defense mechanisms the lung can mount. SP-A in particular, produced by the type II pneumocytes, is active in the innate and adaptive immune system being an opsonin, but also regulating the macr

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Aramini, Beatrice <1979&gt. "Role of SP-A gene polymorphism in lung transplantation." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3634/.

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Lung transplantation is a widely accepted therapeutic option for end stage lung disease. Clinical outcome is yet challenged by primary graft failure responsible for the majority of the early mortality, by chronic allograft dysfunction and chronic rejection accounting for more than 30% of deaths after the third postoperative year. Pulmonary surfactant proteins (SP) A, B, C and D are one of the first host defense mechanisms the lung can mount. SP-A in particular, produced by the type II pneumocytes, is active in the innate and adaptive immune system being an opsonin, but also regulating the macr

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24

Schaffer, Marie. "HLA and KIR gene polymorphism in hematopoietic stem cell transplantation /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-836-3/.

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25

Tarlow, Joanna Karen. "Interleukin-1 receptor antagonist gene polymorphism in chronic inflammatory diseases." Thesis, University of Sheffield, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296761.

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26

Pungliya, Manish S. "Single nucleotide polymorphism analysis in application to fine gene mapping." Digital WPI, 2001. https://digitalcommons.wpi.edu/etd-theses/642.

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Single nucleotide polymorphisms (SNPs) are single base variations among groups of individuals. In order to study their properties in fine gene mapping, I considered their occurrence as transitions and transversions. The aim of the study was to classify each polymorphism depending upon whether it was a transition or transversion and to calculate the proportions of transitions and transversions in the SNP data from the public databases. This ratio was found to be 2.35 for data from the Whitehead Institute for Genome Research database, 2.003 from the Genome Database, and 2.086 from the SNP Consor

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Cavet, James. "Risk factors for graft-versus-host-disease." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250123.

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Riddoch, B. "Selection component analysis of the PGI polymorphism in Sphaeroma rugicauda." Thesis, University of Essex, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378440.

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Davidson, Scott. "Investigating human polymorphism density and transcriptional regulation of the galanin gene." Thesis, University of Aberdeen, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=100111.

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The present study aimed to gain better insights into the distribution of genomic variation, in the form of single nucleotide polymorphisms, within the human genome. Using set theory, the average SNP density of the human genome was found to be 2.6 SNPs per kilobase. This figure decreased with increasing evolutionary depth, i.e. conservation. The conserved exonic, intronic subsets had a lower SNP density than the conserved intergenic subset, suggesting that the conserved exonic and intronic regions are under similar strengths of selective pressure while conserved intergenic regions are under

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Maksymyuk, V. V. "Polymorphism N34S of the SPINK1 gene in patients with acute pancreatitis." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19661.

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Chadwick, Ian George. "Studies on the angiotensin converting enzyme gene polymorphism and ACE inhibitors." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/21136.

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Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II, an important step in the control of blood pressure. The gene encoding for ACE is subject to an insertion/deletion (I/D) polymorphism which is associated with different levels of the enzyme in serum. This polymorphism accounts for 47% of the variability in serum ACE concentrations between subjects but its relevance to tissue ACE is unknown. ACE inhibition increases kinin level, for example bradykinin. Kinins have been proposed be involved in the pathogenesis of cough due to ACE inhibitors, a common adverse effect in t

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Donati, Mauro. "Gene polymorphisms and related cell markers in periodontitis lesions /." Göteborg : Department of Periodontology, Institute of Odontology, The Sahlgrenska Academy at University of Gothenburg, 2009. http://hdl.handle.net/2077/20298.

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Gattan, H. S. M. "Bats and their endoparasites : characterising pipistrelle infections and toll-like receptor (TLR2 and TLR4) gene variations." Thesis, University of Salford, 2017. http://usir.salford.ac.uk/43675/.

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Bats are unique mammals since they are able to fly and due to their crucial ecosystem roles, they are designated as keystone species. However, in many parts of the world, it is difficult to study bats due to the existence of protective legislation caused by their threatened status. Consequently, bat endoparasite studies are limited and even less is known about the bat immune system. To address this paucity of knowledge, this study was conducted using 99 pipistrelle bats (<I>Pipistrellus pipistrellus</I>, n=93 and <I>P. pygmaeus</I>, n=6 bats) that were obtained opportunistically from the Great

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Montgomery, Stephen. "On computational strategies for regulatory element and regulatory polymorphism detection." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/58.

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Identification of the mechanisms by which genes are regulated in eukaryotes is one of the principal challenges of modern biology. The emergence of genome sequencing has facilitated the marked expansion of experimental and computational approaches designed to address this challenge. Integrating and assessing this information remains a major scientific endeavor that requires new and innovative application of technology. Furthermore, our limited understanding of the mechanisms of gene regulation in eukaryotes has undermined our ability to understand the role of genetics in gene regulation. R

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Silva, Fernanda Abujamra da. "Associação da aterosclerose com polimorfismo de TLR2, TLR4, TNF-α e IL-6 e suas expressões em pacientes diabéticos tipo 2." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-23042010-083813/.

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O Diabete tipo 2 é uma síndrome heterogênea caracterizada por resistência à insulina e /ou diminuição relativa da função secretora das células β pancreáticas. Os Diabéticos têm risco maior de desenvolver aterosclerose, que é uma doença inflamatória crônica que envolve a resposta imune. Os TLRs sinalizadores da resposta imune inata que ativam vias que participam na regulação da inflamação podem estar associados com a patogênese da aterosclerose. Além disso, são capazes de induzir a resistência à insulina. Estudos sugerem que a inflamação é um fator chave na aterogênese em diabéticos tipo 2

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Woods, David Richard. "The ACE I/D polymorphism and gene-environment interaction in human performance." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413280.

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Schveigert, Diana. "Matrix metalloproteinases gene expression and their polymorphism in breast and prostate cancer." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20141230_153210-88818.

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Matrix metalloproteinases (MMP) are a family of proteolytic enzymes; these enzymes participate in tumour angiogenesis, processes of tumour growth and development of metastases. Therefore, it is important to evaluate the changes of expression of these enzymes in cancer patients. The aim of this study – to assess the expression of MMP genes and single nucleotide polymorphism in promoter sequences of MMP genes in breast and prostate cancer and evaluate parameters investigated regarding prognosis. The perspective study included 88 female patients with breast cancer and 82 patients with prostate ca

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38

Yu, Chack-yung. "The gene structure and the polymorphism of the human complement component C4." Thesis, University of Oxford, 1987. http://ora.ox.ac.uk/objects/uuid:5a8473fb-01c1-43a1-961b-6c23f41c93f4.

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1. The DNA sequence of the human complement C4A gene from a cosmid clone Cos 3A3 was determined and the complete exon-intron structure elucidated. The 5' flanking region of the C4 gene contains three TATA sequences and a transcriptional enhancer core sequence, which are >200 nucleotides (nt) and 60-70 nt upstream from the CAP site, respectively. The gene consists of 42 exons coding for a precursor protein of 1745 residues. The first exon codes for a 51 nt 5' untranslated sequence, a leader peptide of 19 residues, and the N-terminus of the β chain. The β-α and the α-γ chain junctions are encode

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Kirkpatrick, Alison. "Cytokine gene polymorphism analysis and HPV typing in low grade cervical lesions." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1446468/.

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Persistent high-risk human papillomavirus infection (HPVI) of the uterine cervix is associated with squamous intraepithelial lesions (SIL) and cervical cancer. Low-grade SIL (LSIL) is common but factors determining the outcome are incompletely understood and the management is controversial. The infecting HPV type and the host response to HPVI are thought to be important. Genetic polymorphisms in the regulatory sequences of genes have been identified that are associated with different levels of cytokine expression. These include interieukin 1 alpha (IL-1alpha, 46 base pair VNTR in intron 6), in

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Roldan, Montes Valentina [UNESP]. "Estudo de polimorfismos do gene TLR4 e suas associações com características de importância econômica em búfalas leiteiras." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/144661.

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Submitted by VALENTINA ROLDAN MONTES null (valentiniya@hotmail.com) on 2016-11-14T17:33:47Z No. of bitstreams: 1 dissertação_Valentina_Roldan.pdf: 1303188 bytes, checksum: 91f87b135d433e48cad11782f8d4380d (MD5)<br>Approved for entry into archive by Juliano Benedito Ferreira (julianoferreira@reitoria.unesp.br) on 2016-11-21T13:30:26Z (GMT) No. of bitstreams: 1 roldanmonter_v_me_jabo.pdf: 1303188 bytes, checksum: 91f87b135d433e48cad11782f8d4380d (MD5)<br>Made available in DSpace on 2016-11-21T13:30:26Z (GMT). No. of bitstreams: 1 roldanmonter_v_me_jabo.pdf: 1303188 bytes, checksum: 91f87b135

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Angelo, Sandro Nunes. "Influencia dos polimorfismos T6235C e A4889G, do gene CYP1A1, e dos haplotipos NAT1*3, NAT1*4 e NAT1*10 do gene NAT1, associados com o metabolismo de carcinogenos, na susceptibilidade ao adenocarcinoma colorretal esporadico." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308618.

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Orientadores: Carmen Silvia Passos Lima, Claudio Saddy Rodrigues Coy<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-12T04:46:06Z (GMT). No. of bitstreams: 1 Angelo_SandroNunes_M.pdf: 2804773 bytes, checksum: b88b1fbf49effea5eae1bf248bc95389 (MD5) Previous issue date: 2008<br>Resumo: A exposição das células do cólon e do reto a substâncias carcinogênicas está associada ao consumo de alimentos que constituam fonte de substratos, como aminas aromáticas e hidrocarbonetos aromáticos policiclícos. Enzimas como a m

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El-Sakka, N. "Polymorphism of the manganese superoxide dismutase gene : relevance to mitochondrial dysfuntion and sepsis." Thesis, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419715.

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Dhar, Kalyan K. "Analysis of cyclin D1 gene (CCND1) polymorphism and expression in epithelial ovarian cancer." Thesis, Keele University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.344055.

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Iftoda, O. M. "Gender aspects of connexin 26 (GJB2) gene polymorphism in children with hearing loss." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19712.

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Kmyta, V. "Bcli polymorphism of glucocorticoid receptor gene in patients with bronchial asthma and obesity." Thesis, Sumy State University, 2015. http://essuir.sumdu.edu.ua/handle/123456789/40552.

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Certain investigations showed that genetic factors of bronchial asthma (BA) and obesity overlap each other, this indicates that they have common genetic predisposition. Thus, BA and obesity are associated with the genes, which encode β-adrenergic receptor, insulin-like growth factor, IL-1α, leukotriene A4 hydroxylase, glucocorticoid receptor (GR), uncoupling protein, etc.

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Chumakov, V., Олександр Леонідович Ситнік, Александр Леонидович Сытник, Oleksandr Leonidovych Sytnik, and A. Dmitruk. "Polymorphism of gene of IL-8 cytokine in acute pancreatitis complicated with peritonitis." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/63611.

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This study has assessed the possible association of IL-8 (-251А/Т) polymorphism with clinical course of pancreatogenic peritonitis and suggests that the identification of genetic polymorphism of IL-8 (-251A/T) may be informative and serve as an additional criterion to predict both the clinical course and outcome of pancreatogenic peritonitis.<br>Te studium zostało przeprowadzone w celu określenia możliwego związku miedzy genetycznym polimorfem cytokiny IL-8 (-251А/Т), a jego wpływu na warianty klinicznego przebiegu ostrego zapalenia trzustki, skomplikowanego zapaleniem otrzewnej i może d

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Wang, Tian-You, and 王天佑. "An Investigation on the Association between TLR4 Gene Polymorphism and Periodontal Disease in a Taiwan Han Population." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/73975649107569980050.

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碩士<br>高雄醫學大學<br>牙醫學研究所<br>100<br>Objectives: Periodontitis is an inflammatory disease that affecting the periodontal connective supporting tissues. Gene polymorphisms of Toll-like receptor could affect the host’s ability to respond to microbial pathogens. This study aimed to investigate the possible association between TLR4 gene polymorphism and periodontal disease in a Taiwan Han population. Material and methods: Genomic DNA was obtained from the peripheral blood of 122 patients with chronic periodontitis (CP), 84 patients with (aggressive periodontitis (AgP) and 64 periodontally healthy s

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Těšický, Martin. "Mezidruhový polymorfismus vybraných genů vrozené imunity u sýkor (Paridae)." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-411457.

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Adaptation of host receptor system to optimal detection of infection-related structures is one of the key evolutionary challenges of immunity in host-pathogen interactions. Toll-like receptors (TLRs) are genetically variable molecules of vertebrate innate immunity that recognise danger signals, e.g. pathogenic molecules. Examination of genetic variation in TLRs may reveal mechanisms of host immunity adaptation to pathogenic pressure at molecular level. Trans-species polymorphism (TSP) is a phenomenon which assumes that several identical alleles or allelic lineages are inherited from ascendant

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Askar, Eva. "Chronic hepatitis C: Liver disease manifestations with regard to respective innate immunity receptors gene polymorphisms." Thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-0006-B1FD-8.

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Etwa 3% der Weltbevölkerung sind von dem Hepatitis-C-Virus-Infektion betroffen. Phänotyp der HCV-induzierten Lebererkrankung variiert stark von einem Patienten zum anderen. Die Wahrnehmung der viralen doppelsträngigen RNA (dsRNA) und einzelsträngigen RNA (ssRNA) durch den Toll-like-Rezeptor 3 (TLR3) bzw. TLR7 scheinen an der Früherkennung der Pathogene und an der Wirtsantwort auf viraler Infektion beteiligt zu sein. Darüber hinaus ist die membran-assoziierte Form des Endotoxin-Rezeptor

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Wang, Chiou-Huey, and 王秋惠. "Association of TLR8 gene polymorphisms with Hepatitis C virus infection." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/9s3u9s.

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博士<br>高雄醫學大學<br>醫學研究所-基礎醫學組<br>102<br>Toll-like receptors (TLRs) play pivotal roles in the innate immune system and control inflammatory responses and adaptive immunity. Growing amounts of data suggest that the ability of individuals to respond to TLR ligands may be different due to single nucleotide polymorphisms (SNPs) within TLR genes, resulting in an altered susceptibility to infectious diseases. TLR8 located in X chromosome, activates downstream signals to induce inflammatory cytokines and type I interferon through recognizing single-stranded RNA. In our previous study, we found that a TL

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