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1

England, R. M., J. I. Hare, P. D. Kemmitt, K. E. Treacher, M. J. Waring, S. T. Barry, C. Alexander, and M. Ashford. "Enhanced cytocompatibility and functional group content of poly(l-lysine) dendrimers by grafting with poly(oxazolines)." Polymer Chemistry 7, no. 28 (2016): 4609–17. http://dx.doi.org/10.1039/c6py00478d.

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We report the use of polyoxazolines as materials for modifying the surface of a generation 5 l-lysine dendrimer resulting in a significant improvement in the biocompatibility properties compared to the unmodified dendrimer. The polyoxazoline coatings represent interesting alternatives to polyethylene glycol and can also offer an opportunity for increasing drug loading.
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2

Sťahel, Pavel, Věra Mazánková, Klára Tomečková, Petra Matoušková, Antonín Brablec, Lubomír Prokeš, Jana Jurmanová, et al. "Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance." Polymers 11, no. 12 (December 12, 2019): 2069. http://dx.doi.org/10.3390/polym11122069.

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Polyoxazolines are a new promising class of polymers for biomedical applications. Antibiofouling polyoxazoline coatings can suppress bacterial colonization of medical devices, which can cause infections to patients. However, the creation of oxazoline-based films using conventional methods is difficult. This study presents a new way to produce plasma polymerized oxazoline-based films with antibiofouling properties and good biocompatibility. The films were created via plasma deposition from 2-methyl-2-oxazoline vapors in nitrogen atmospheric pressure dielectric barrier discharge. Diverse film properties were achieved by increasing the substrate temperature at the deposition. The physical and chemical properties of plasma polymerized polyoxazoline films were studied by SEM, EDX, FTIR, AFM, depth-sensing indentation technique, and surface energy measurement. After tuning of the deposition parameters, films with a capacity to resist bacterial biofilm formation were achieved. Deposited films also promote cell viability.
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3

Oudin, Amandine, Julie Chauvin, Laure Gibot, Marie-Pierre Rols, Stéphanie Balor, Dominique Goudounèche, Bruno Payré, et al. "Amphiphilic polymers based on polyoxazoline as relevant nanovectors for photodynamic therapy." Journal of Materials Chemistry B 7, no. 32 (2019): 4973–82. http://dx.doi.org/10.1039/c9tb00118b.

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4

Mazánková, Věra, Pavel Sťahel, Petra Matoušková, Antonín Brablec, Jan Čech, Lubomír Prokeš, Vilma Buršíková, et al. "Atmospheric Pressure Plasma Polymerized 2-Ethyl-2-oxazoline Based Thin Films for Biomedical Purposes." Polymers 12, no. 11 (November 13, 2020): 2679. http://dx.doi.org/10.3390/polym12112679.

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Polyoxazoline thin coatings were deposited on glass substrates using atmospheric pressure plasma polymerization from 2-ethyl-2-oxazoline vapours. The plasma polymerization was performed in dielectric barrier discharge burning in nitrogen at atmospheric pressure. The thin films stable in aqueous environments were obtained at the deposition with increased substrate temperature, which was changed from 20 ∘C to 150 ∘C. The thin film deposited samples were highly active against both S. aureus and E. coli strains in general. The chemical composition of polyoxazoline films was studied by FTIR and XPS, the mechanical properties of films were studied by depth sensing indentation technique and by scratch tests. The film surface properties were studied by AFM and by surface energy measurement. After tuning the deposition parameters (i.e., monomer flow rate and substrate temperature), stable films, which resist bacterial biofilm formation and have cell-repellent properties, were achieved. Such antibiofouling polyoxazoline thin films can have many potential biomedical applications.
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5

Beck, M., P. Birnbrich, U. Eicken, H. Fischer, W. E. Fristad, B. Hase, and H. J. Krause. "Polyoxazoline auf fettchemischer Basis." Angewandte Makromolekulare Chemie 223, no. 1 (December 1994): 217–33. http://dx.doi.org/10.1002/apmc.1994.052230116.

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6

Rayeroux, David, Christophe Travelet, Vincent Lapinte, Redouane Borsali, Jean-Jacques Robin, and Cécile Bouilhac. "Tunable amphiphilic graft copolymers bearing fatty chains and polyoxazoline: synthesis and self-assembly behavior in solution." Polymer Chemistry 8, no. 29 (2017): 4246–63. http://dx.doi.org/10.1039/c7py00632b.

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7

Ramiasa, M. N., A. A. Cavallaro, A. Mierczynska, S. N. Christo, J. M. Gleadle, J. D. Hayball, and K. Vasilev. "Plasma polymerised polyoxazoline thin films for biomedical applications." Chemical Communications 51, no. 20 (2015): 4279–82. http://dx.doi.org/10.1039/c5cc00260e.

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We report novel solvent-free and substrate independent, plasma polymerised nanoscale biocompatible polyoxazoline coatings capable of controlling protein and cell adhesion, and significantly reducing biofilm build up.
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8

Legros, Camille, Marie-Claire De Pauw-Gillet, Kam Chiu Tam, Daniel Taton, and Sébastien Lecommandoux. "Crystallisation-driven self-assembly of poly(2-isopropyl-2-oxazoline)-block-poly(2-methyl-2-oxazoline) above the LCST." Soft Matter 11, no. 17 (2015): 3354–59. http://dx.doi.org/10.1039/c5sm00313j.

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9

Morgese, Giulia, and Edmondo M. Benetti. "Polyoxazoline biointerfaces by surface grafting." European Polymer Journal 88 (March 2017): 470–85. http://dx.doi.org/10.1016/j.eurpolymj.2016.11.003.

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10

Macgregor-Ramiasa, Melanie N., Alex A. Cavallaro, and Krasimir Vasilev. "Properties and reactivity of polyoxazoline plasma polymer films." Journal of Materials Chemistry B 3, no. 30 (2015): 6327–37. http://dx.doi.org/10.1039/c5tb00901d.

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Nanoscale polyoxazoline coatings generated via a single step plasma deposition process are investigated. The complex functionality of the film can be controlled by varying the deposition conditions. Partial retention of the oxazoline ring facilitates covalent binding of nanoparticles and biomolecules.
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11

Korchia, L., C. Bouilhac, A. Aubert, J. J. Robin, and V. Lapinte. "Light-switchable nanoparticles based on amphiphilic diblock, triblock and heterograft polyoxazoline." RSC Advances 7, no. 68 (2017): 42690–98. http://dx.doi.org/10.1039/c7ra07094b.

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Photo-active nanoparticles (NPD, NPT, NPH) were elaborated in water from amphiphilic diblock (D), triblock (T) and heterograft (H) copolymers based on a chromatic unit, coumarin, linked to an alkyl chain and a hydrophilic polyoxazoline chain.
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12

Gil Alvaradejo, Gabriela, Mathias Glassner, Richard Hoogenboom, and Guillaume Delaittre. "Maleimide end-functionalized poly(2-oxazoline)s by the functional initiator route: synthesis and (bio)conjugation." RSC Advances 8, no. 17 (2018): 9471–79. http://dx.doi.org/10.1039/c8ra00948a.

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13

CHUJO, Yoshiki, Eiji IHARA, and Takeo SAEGUSA. "Synthesis of Polyoxazoline-Polysiloxane Block Copolymers." KOBUNSHI RONBUNSHU 49, no. 11 (1992): 943–46. http://dx.doi.org/10.1295/koron.49.943.

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14

Hruby, Martin, Sergey K. Filippov, Jiri Panek, Michaela Novakova, Hana Mackova, Jan Kucka, David Vetvicka, and Karel Ulbrich. "Polyoxazoline Thermoresponsive Micelles as Radionuclide Delivery Systems." Macromolecular Bioscience 10, no. 8 (May 20, 2010): 916–24. http://dx.doi.org/10.1002/mabi.201000034.

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15

Velander, William H., Rapti D. Madurawe, Anuradha Subramanian, Guneet Kumar, Gurudas Sinai-Zingde, Judy S. Riffle, and Carolyn L. Orthner. "Polyoxazoline-Peptide adducts that retain antibody avidity." Biotechnology and Bioengineering 39, no. 10 (April 25, 1992): 1024–30. http://dx.doi.org/10.1002/bit.260391006.

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16

Harris, J. Milton, Michael D. Bentley, Randall W. Moreadith, Tacey X. Viegas, Zhihao Fang, Kunsang Yoon, Rebecca Weimer, Bekir Dizman, and Lars Nordstierna. "Tuning drug release from polyoxazoline-drug conjugates." European Polymer Journal 120 (November 2019): 109241. http://dx.doi.org/10.1016/j.eurpolymj.2019.109241.

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17

Dong, Lichao, Tian Lan, Yin Liang, Shifeng Guo, and Hao Zhang. "Correction: Metal-free [2+2+1] cycloaddition polymerization of alkynes, nitriles, and oxygen atoms to functional polyoxazoles." RSC Advances 11, no. 4 (2021): 2292. http://dx.doi.org/10.1039/d0ra90139c.

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Correction for ‘Metal-free [2+2+1] cycloaddition polymerization of alkynes, nitriles, and oxygen atoms to functional polyoxazoles’ by Lichao Dong et al., RSC Adv., 2020, 10, 24368–24373, DOI: 10.1039/D0RA04249H.
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18

Dong, Lichao, Tian Lan, Yin Liang, Shifeng Guo, and Hao Zhang. "Retraction: Metal-free [2+2+1] cycloaddition polymerization of alkynes, nitriles, and oxygen atoms to functional polyoxazoles." RSC Advances 11, no. 27 (2021): 16200. http://dx.doi.org/10.1039/d1ra90113c.

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Retraction of ‘Metal-free [2+2+1] cycloaddition polymerization of alkynes, nitriles, and oxygen atoms to functional polyoxazoles’ by Lichao Dong et al., RSC Adv., 2020, 10, 24368–24373, DOI: 10.1039/D0RA04249H.
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19

Bogomolova, Anna, Martin Hruby, Jiri Panek, Maria Rabyk, Stuart Turner, Sara Bals, Milos Steinhart, et al. "Small-angle X-ray scattering and light scattering study of hybrid nanoparticles composed of thermoresponsive triblock copolymer F127 and thermoresponsive statistical polyoxazolines with hydrophobic moieties." Journal of Applied Crystallography 46, no. 6 (November 7, 2013): 1690–98. http://dx.doi.org/10.1107/s0021889813027064.

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A combination of new thermoresponsive statistical polyoxazolines, poly[(2-butyl-2-oxazoline)-stat-(2-isopropyl-2-oxazoline)] [pBuOx-co-piPrOx], with different hydrophobic moieties and F127 surfactant as a template system for the creation of thermosensitive nanoparticles for radionuclide delivery has recently been tested [Pánek, Filippov, Hrubý, Rabyk, Bogomolova, Kučka & Stěpánek (2012).Macromol. Rapid Commun.33, 1683–1689]. It was shown that the presence of the thermosensitive F127 triblock copolymer in solution reduces nanoparticle size and polydispersity. This article focuses on a determination of the internal structure and solution properties of the nanoparticles in the temperature range from 288 to 312 K. Here, it is demonstrated that below the cloud point temperature (CPT) the polyoxazolines and F127 form complexes that co-exist in solution with single F127 molecules and large aggregates. When the temperature is raised above the CPT, nanoparticles composed of polyoxazolines and F127 are predominant in solution. These nanoparticles could be described by a spherical shell model. It was found that the molar weight and hydrophobicity of the polymer do not influence the size of the outer radius and only slightly change the inner radius of the nanoparticles. At the same time, molar weight and hydrophobicity did affect the process of nanoparticle formation. In conclusion, poly(2-oxazoline) molecules are fully incorporated inside of F127 micelles, and this result is very promising for the successful application of such systems in radionuclide delivery.
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20

Viegas, Tacey X., Michael D. Bentley, J. Milton Harris, Zhihao Fang, Kunsang Yoon, Bekir Dizman, Rebecca Weimer, Anna Mero, Gianfranco Pasut, and Francesco M. Veronese. "Polyoxazoline: Chemistry, Properties, and Applications in Drug Delivery." Bioconjugate Chemistry 22, no. 5 (May 18, 2011): 976–86. http://dx.doi.org/10.1021/bc200049d.

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21

Morgese, Giulia, Valerio Causin, Michele Maggini, Stefano Corrà, Silvia Gross, and Edmondo M. Benetti. "Ultrastable Suspensions of Polyoxazoline-Functionalized ZnO Single Nanocrystals." Chemistry of Materials 27, no. 8 (April 7, 2015): 2957–64. http://dx.doi.org/10.1021/acs.chemmater.5b00252.

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22

Chujo, Yoshiki, Kazuki Sada, Akio Naka, Ryoji Nomura, and Takeo Saegusa. "Synthesis and redox gelation of disulfide-modified polyoxazoline." Macromolecules 26, no. 5 (September 1993): 883–87. http://dx.doi.org/10.1021/ma00057a001.

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23

Celebi, O., C. H. Lee, Y. Lin, J. E. McGrath, and J. S. Riffle. "Synthesis and characterization of polyoxazoline–polysulfone triblock copolymers." Polymer 52, no. 21 (September 2011): 4718–26. http://dx.doi.org/10.1016/j.polymer.2011.08.018.

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24

Sultana, S., T. Zuberi, and M. J. Lawrence. "Physico-chemical characterization of non-ionic polyoxazoline surfactants." Journal of Pharmacy and Pharmacology 50, S9 (September 1998): 176. http://dx.doi.org/10.1111/j.2042-7158.1998.tb02376.x.

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25

Diehl, Christina, and Helmut Schlaad. "Polyoxazoline-based Crystalline Microspheres for Carbohydrate-Protein Recognition." Chemistry - A European Journal 15, no. 43 (September 25, 2009): 11469–72. http://dx.doi.org/10.1002/chem.200901420.

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26

Zhang, Peng, Kangjun Yuan, Cheng Li, Xiaoke Zhang, Wei Wu, and Xiqun Jiang. "Cisplatin-Rich Polyoxazoline-Poly(aspartic acid) Supramolecular Nanoparticles." Macromolecular Bioscience 17, no. 12 (October 25, 2017): 1700206. http://dx.doi.org/10.1002/mabi.201700206.

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27

Kure, S., Y. Chujo, and T. Saegusa. "An organic-inorganic hybrid polymer derived from polyoxazoline." Reactive Polymers 15 (November 1991): 241–42. http://dx.doi.org/10.1016/0923-1137(91)90204-2.

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28

Chujo, Yoshiki, Kazuki Sada, Takeshi Kawasaki, Eiji Ihara, and Takeo Saegusa. "Gelation of telechelic trimethoxysilyl-terminated polyoxazolines." Polymer Bulletin 31, no. 3 (September 1993): 311–16. http://dx.doi.org/10.1007/bf00692957.

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29

Qi, Fuling, Lianxun Gao, and Fushe Han. "Design and synthesis of macrocyclic polyoxazoles." Chemical Research in Chinese Universities 30, no. 4 (July 5, 2014): 587–92. http://dx.doi.org/10.1007/s40242-014-4069-z.

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30

Iida, Keisuke, and Kazuo Nagasawa. "Macrocyclic Polyoxazoles as G-Quadruplex Ligands." Chemical Record 13, no. 6 (November 13, 2013): 539–48. http://dx.doi.org/10.1002/tcr.201300015.

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31

Tsutsumiuchi, Kaname, Keigo Aoi, and Masahiko Okada. "Synthesis of Polyoxazoline−(Glyco)peptide Block Copolymers by Ring-Opening Polymerization of (Sugar-Substituted) α-Amino AcidN-Carboxyanhydrides with Polyoxazoline Macroinitiators." Macromolecules 30, no. 14 (July 1997): 4013–17. http://dx.doi.org/10.1021/ma970086p.

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32

Sinai-Zingde, G., A. Verma, Q. Liu, A. Brink, J. M. Bronk, H. Marand, J. E. McGrath, and J. S. Riffle. "Polyoxazoline containing copolymers useful as emulsifiers for polymer blends." Makromolekulare Chemie. Macromolecular Symposia 42-43, no. 1 (March 1991): 329–43. http://dx.doi.org/10.1002/masy.19910420127.

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33

Chujo, Yoshiki, Kazuki Sada, Takeshi Kawasaki, and Takeo Saegusa. "Synthesis of Non-Ionic Hydrogel from Star-Shaped Polyoxazoline." Polymer Journal 24, no. 11 (1992): 1301–6. http://dx.doi.org/10.1295/polymj.24.1301.

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34

Chujo, Yoshikl, Eiji Ihara, Hiroyashu lhara, and Takeo Saegusa. "Synthesis of polysiloxane-polyoxazoline graft copolymer by hydrosilylation reaction." Polymer Bulletin 19, no. 5 (May 1988): 435–40. http://dx.doi.org/10.1007/bf00263911.

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35

Diehl, Christina, and Helmut Schlaad. "Thermo-Responsive Polyoxazolines with Widely Tuneable LCST." Macromolecular Bioscience 9, no. 2 (November 13, 2008): 157–61. http://dx.doi.org/10.1002/mabi.200800213.

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36

Dworak, Andrzej, Barbara Trzebicka, Agnieszka Kowalczuk, Christo Tsvetanov, and Stanislav Rangelov. "Polyoxazolines — mechanism of synthesis and solution properties." Polimery 59, no. 01 (January 2014): 88–94. http://dx.doi.org/10.14314/polimery.2014.088.

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37

Gonzalez Garcia, Laura E., Melanie MacGregor-Ramiasa, Rahul Madathiparambil Visalakshan, and Krasimir Vasilev. "Protein Interactions with Nanoengineered Polyoxazoline Surfaces Generated via Plasma Deposition." Langmuir 33, no. 29 (July 11, 2017): 7322–31. http://dx.doi.org/10.1021/acs.langmuir.7b01279.

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38

Alexis, Cédric, Clarence Charnay, Vincent Lapinte, and Jean-Jacques Robin. "Hydrophilization by coating of silylated polyoxazoline using sol–gel process." Progress in Organic Coatings 76, no. 4 (April 2013): 519–24. http://dx.doi.org/10.1016/j.porgcoat.2012.09.012.

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39

Chujo, Yoshiki, Kazuki Sada, and Takeo Saegusa. "Reversible gelation of polyoxazoline by means of Diels-Alder reaction." Macromolecules 23, no. 10 (May 1990): 2636–41. http://dx.doi.org/10.1021/ma00212a007.

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40

Kim, Kyung-Min, Dong-Ki Keum, and Yoshiki Chujo. "Organic−Inorganic Polymer Hybrids Using Polyoxazoline Initiated by Functionalized Silsesquioxane." Macromolecules 36, no. 3 (February 2003): 867–75. http://dx.doi.org/10.1021/ma021303b.

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41

Einzmann, Mirko, and Wolfgang H. Binder. "Novel initiators for oxazoline polymerization: generation of polydiacetylene-polyoxazoline networks." Macromolecular Symposia 181, no. 1 (May 2002): 57–62. http://dx.doi.org/10.1002/1521-3900(200205)181:1<57::aid-masy57>3.0.co;2-6.

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42

Venturini, Pierre, Solenne Fleutot, Franck Cleymand, Thomas Hauet, Jean‐Charles Dupin, Jaafar Ghanbaja, Hervé Martinez, Jean‐Jacques Robin, and Vincent Lapinte. "Facile One‐Step Synthesis of Polyoxazoline‐Coated Iron Oxide Nanoparticles." ChemistrySelect 3, no. 42 (November 13, 2018): 11898–901. http://dx.doi.org/10.1002/slct.201802234.

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43

Korchia, Laetitia, Vincent Lapinte, Christophe Travelet, Redouane Borsali, Jean-Jacques Robin, and Cécile Bouilhac. "UV-responsive amphiphilic graft copolymers based on coumarin and polyoxazoline." Soft Matter 13, no. 25 (2017): 4507–19. http://dx.doi.org/10.1039/c7sm00682a.

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44

Kroning, Annika, Andreas Furchner, Stefan Adam, Petra Uhlmann, and Karsten Hinrichs. "Probing carbonyl–water hydrogen-bond interactions in thin polyoxazoline brushes." Biointerphases 11, no. 1 (March 2016): 019005. http://dx.doi.org/10.1116/1.4939249.

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45

Volet, Gisèle, and Catherine Amiel. "Polyoxazoline adsorption on silica nanoparticles mediated by host–guest interactions." Colloids and Surfaces B: Biointerfaces 91 (March 2012): 269–73. http://dx.doi.org/10.1016/j.colsurfb.2011.11.018.

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46

Gutberlet, T., A. Wurlitzer, U. Dietrich, E. Politsch, G. Cevc, R. Steitz, and M. Lösche. "Organization of tethered polyoxazoline polymer brushes at the air/water interface." Physica B: Condensed Matter 283, no. 1-3 (June 2000): 37–39. http://dx.doi.org/10.1016/s0921-4526(99)01887-6.

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47

Ogoshi, Tomoki, and Yoshiki Chujo. "Synthesis of colloidal polyoxazoline/silica hybrids prepared in an aqueous solution." Polymer 47, no. 11 (May 2006): 4036–41. http://dx.doi.org/10.1016/j.polymer.2006.02.042.

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48

Macgregor, Melanie N., Andrew Michelmore, Hanieh Safizadeh Shirazi, Jason Whittle, and Krasimir Vasilev. "Secrets of Plasma-Deposited Polyoxazoline Functionality Lie in the Plasma Phase." Chemistry of Materials 29, no. 19 (September 29, 2017): 8047–51. http://dx.doi.org/10.1021/acs.chemmater.7b03023.

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49

Chujo, Yoshiki, Kazuki Sada, and Takeo Saegusa. "Iron(II) bipyridyl-branched polyoxazoline complex as a thermally reversible hydrogel." Macromolecules 26, no. 24 (November 1993): 6315–19. http://dx.doi.org/10.1021/ma00076a001.

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50

Morgese, Giulia, Shivaprakash N. Ramakrishna, Rok Simic, Marcy Zenobi-Wong, and Edmondo M. Benetti. "Hairy and Slippery Polyoxazoline-Based Copolymers on Model and Cartilage Surfaces." Biomacromolecules 19, no. 2 (January 11, 2018): 680–90. http://dx.doi.org/10.1021/acs.biomac.7b01828.

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