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Dissertations / Theses on the topic 'Polypeptiden'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Kukula, Hildegard. "Lineare und verzweigte Blockcopolymere aus Polypeptiden und synthetischen Polymeren." Phd thesis, [S.l.] : [s.n.], 2001. http://pub.ub.uni-potsdam.de/2001/0014/kukula.pdf.

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2

Wildemann, Dirk. "Charakterisierung von Einzelbindungs-Konformationsänderungen in Polypeptiden durch chemische Modifikation und Enzymkatalyse." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=97564694X.

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3

Wichmann, Christoph [Verfasser], and Paul [Akademischer Betreuer] Tavan. "Das spektroskopische polarisierbare Kraftfeld für Amidgruppen in Polypeptiden / Christoph Wichmann ; Betreuer: Paul Tavan." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1160876258/34.

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4

Simanski, Maren [Verfasser]. "Molekulare Charakterisierung von antimikrobiellen und cytolytischen Polypeptiden von Acanthamoeba culbertsoni, einem freilebenden und potenziell humanpathogenen Protozoon / Maren Simanski." Kiel : Universitätsbibliothek Kiel, 2008. http://d-nb.info/1019543329/34.

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5

Aronsson, Christopher. "Tunable and modular assembly of polypeptides and polypeptide-hybrid biomaterials." Doctoral thesis, Linköpings universitet, Molekylär fysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-132949.

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Biomaterials are materials that are specifically designed to be in contact with biological systems and have for a long time been used in medicine. Examples of biomaterials range from sophisticated prostheses used for replacing outworn body parts to ordinary contact lenses. Currently it is possible to create biomaterials that can e.g. specifically interact with cells or respond to certain stimuli. Peptides, the shorter version of proteins, are excellent molecules for fabrication of such biomaterials. By following and developing design rules it is possible to obtain peptides that can self-assemb

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6

Billeter, Martin Urs. "Strukturermittlung von Polypeptiden und kleinen Proteinen auf der Basis von H-1-NMR Daten mittels Computer-Graphik und Optimierung /." Zürich, 1985. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=7723.

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7

Meyer, Matthias. "PIPOX-PEP kontrollierte Synthese und Aggregationsverhalten von Blockcopolymeren mit schaltbarer Hydrophilie /." Phd thesis, [S.l.] : [s.n.], 2006. http://opus.kobv.de/ubp/volltexte/2006/1083.

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8

Xiao, Ye. "Synthesis and self-assembly of polysaccharide-b-elastin-like polypeptide bioconjugates." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0172.

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L’association de polysaccharides naturels et de polypeptides recombinants de type élastine (ELP) dans des structures de copolymères à blocs doit permettre d’accéder à des matériaux possédant des propriétés d’auto-assemblage sous l’action de stimuli et potentiellement bioactifs. Nous avons réalisé et présentons ici la synthèse d'une série de bioconjugués polysaccharide-b-ELP, dans lesquels 4 polysaccharides hydrophiles différents ont été couplés à l'extrémité N-terminale de l’ELP par "chimie click".Ces bioconjugués ont été caractérisés par RMN 1D et 2D, SEC et FTIR. Leur thermo-sensibilité et l

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9

Ji, Sifan. "Analogues polypeptides intelligents de la protéine fluorescente verte." Electronic Thesis or Diss., Bordeaux, 2025. http://www.theses.fr/2025BORD0010.

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La protéine fluorescente verte (GFP) s'est imposée comme une sonde fluorescente unique qui trouve des applications dans le domaine des sciences de la vie. La découverte et le développement de la GFP ont été dûment récompensés par le prix Nobel de chimie en 2008. La protéine se compose d'un chromophore central, intégré dans une chaîne polypeptidique hélicoïdale et encapsulé dans une cage protéique. Ces dernières années, des fluorophores synthétiques analogues au chromophore de la GFP ont été développés dans le but d'imiter les propriétés de fluorescence de la protéine et de ses dérivés. Ces flu

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10

Ng, Yuen-lam Stephanie, and 吳宛霖. "Identification of VIP, PACAP and their receptors in agnathans: insights into the ancestral origin of theligands and receptors." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45704879.

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11

Cimmino, Teresa. "Whole genome sequencing to decipher the resistome of clinical multidrug-resistant bacteria." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM5068/document.

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WGS permet d'analyser et de déchiffrer l'étude de résistances de bactéries multirésistantes(MDR), en comprenant les différents mécanismes de résistance, les annuaires génétiques. Au cours de ma thèse de doctorat, j'ai réalisé: 1 revue de la littérature sur l'utilisation de nouveaux outils de diagnostic contemporains et les capacités dans la détection des foyers dans les maladies infectieuses causées par MDR. L'identification et l'analyse de résistances de bactéries multirésistantes Comme étant des Shewanellalgae, normalement de l'environnement marin, dans notre cas une souche clinique isolée d

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12

Göransson, Ulf. "Macrocyclic polypeptides from plants." Doctoral thesis, Uppsala University, Department of Medicinal Chemistry, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1956.

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<p>The aim of this work was to explore the structural and functional diversity of polypeptides that are found in plants. Expanding knowledge of simililarities between plant use of these compound and animal use promises exceptional opportunities for finding, from plant research, new structures with biomedical and biotechnological potential.</p><p>A fractionation protocol was developed and applied to many plant species, providing fractions enriched in polypeptides, amenable to chemical and biological evaluation. From one species, the common field pansy (<i>Viola arvensis</i>), a 29-amino-acid re

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13

Petry, Renate. "Spektroskopische Strukturanalytik synthetischer Polypeptide." Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=969651074.

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14

Aili, Daniel. "Polypeptide-Based Nanoscale Materials." Doctoral thesis, Linköpings universitet, Sensorvetenskap och Molekylfysik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15124.

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Self-assembly has emerged as a promising technique for fabrication of novel hybrid materials and nanostructures. The work presented in this thesis has been focused on developing nanoscale materials based on synthetic de novo designed polypeptides. The polypeptides have been utilized for the assembly of gold nanoparticles, fibrous nanostructures, and for sensing applications. The 42-residue polypeptides are designed to fold into helix-loop-helix motifs and dimerize to form four-helix bundles. Folding is primarily driven by the formation of a hydrophobic core made up by the hydrophobic faces of

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15

Gelling, Richard Wayne. "Structure-function studies of the gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (GIP) receptor." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34523.pdf.

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16

Mortenson, Paul Neil. "Energy landscapes of model polypeptides." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621232.

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17

Monreal, Jorge. "Polymer Characteristics of Polyelectrolyte Polypeptides." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6326.

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Polypeptides are polymerized chains of amino acids linked covalently through peptide bonds. Polyelectrolyte polypeptides are polypeptides with electrolyte repeating groups. Several amino acids contain ionizable side chains which result in charge distributions when dissolved in aqueous solutions. This dissertation is motivated by a desire to gain knowledge of polyelectrolyte polypeptides as recent advances in chemical synthesis of polypeptides have made possible the fabrication of designed polypeptides that do not naturally occur in nature. Potential applications of newly designed polypeptides

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18

Gunther, Selina Lavinia. "Polypeptide extraction using reverse micelles." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5529.

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The reverse micelle (RM) extraction of human IgG4 monoclonal antibodies (MAbs), humanized IgG4 MAb B72.3 Fab fragments and horse heart cytochrome-c was investigated. The effects of system parameters on forward (FE) and backward (BE) extraction was examined, and optimal extraction conditions were determined. Sodium bis(2-ethylhexyl)sulfosuccinate (AOT), bis(2-ethylhexyl)phosphate (HDEHP), isooctane and corn oil were the model surfactants and solvents. Precipitate formation was investigated, and non-ionic (polyoxyethylene(4) lauryl ether i.e. Brij 30) and counterionic (trioctylmethylammonium chl

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19

Mullin, M. J. "Combinatorial studies on the B-loop residues of human epidermal growth factor." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273233.

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20

Smith, Dawn. "Protein distribution between cytoplasmic and thylakoid membranes of cyanobacteria." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282019.

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21

Deller, Marc Christian. "Structural studies of cytokines and cytokine receptors." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326028.

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22

Meillon, Jean Christophe. "Transport transmembranaire et auto-assemblage impliquant des peptides synthétiques modifiés." Sherbrooke : Université de Sherbrooke, 1998.

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23

Fahnenschmidt, Monika. "De-novo-synthetisierte Proteine mit Metalloporphyrinkofaktoren." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=959723854.

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24

Rubini, Marina. "Protein engineering and design with non canonical amino acids." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974166073.

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25

Phelps, Andrea Lee. "Metal catalyzed copolymerization processes involving carbon oxides as substrates." Texas A&M University, 2005. http://hdl.handle.net/1969.1/2531.

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Studies concerning two different copolymerization processes are detailed in this dissertation: propylene oxide/CO2 coupling to afford poly(propylene carbonate) and Nbutylaziridine/ CO coupling to afford poly-??-butylalanoid. The copolymerization of propylene oxide and CO2 to form the industrially useful poly(propylene carbonate) has been investigated employing chromium(salen)N3 complexes as catalysts. Unfortunately the reaction could not be studied in real time via in situ infrared spectroscopy, thereby obtaining detailed kinetic data, because of the copolymer-limited solubility in most solven

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26

Crick, F. "Polypeptides and proteins : X-ray studies." Thesis, University of Cambridge, 2013. https://www.repository.cam.ac.uk/handle/1810/250994.

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27

Oomen, Ray. "Interaction of polypeptides with lipid bilayers." Thesis, University of Ottawa (Canada), 1988. http://hdl.handle.net/10393/5253.

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28

Ling, Roger. "Polypeptides of murine and avian pneumoviruses." Thesis, University of Warwick, 1988. http://wrap.warwick.ac.uk/55532/.

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The work described in this thesis identifies some properties of the major polypeptides of pneumonia virus of mice (PVM) and of turkey rhinotracheitis (TRT) virus. The PVM glycoproteins have been studied in particular detail while the results obtained with TRT virus provide a preliminary description of the polypeptides of this virus. Twelve major PVM specific polypeptides designated L, G1, G2, F1, N, 39K, 35K, M, 20K, 19K, 16K and 12K were identified. In addition PVM specific polypeptides designated 25K, 24K, 23K, 18K and 17K were sometimes detected. Monoclonal antibodies directed against the G

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29

Galbraith, Toby Patrick. "Biophysical studies of membrane channel polypeptides." Thesis, Birkbeck (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249171.

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30

Denschlag, Robert. "Effizientes Abtasten der Gleichgewichtsensembles gelöster Polypeptide." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-119364.

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31

Ponter, Andrew A. "Dietary manipulation of gastric inhibitory polypeptide." Thesis, University of Reading, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280307.

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32

Wiltzius, Jed John William. "Structural studies of islet amyloid polypeptide." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1691848941&sid=6&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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33

Scanlan, D. J. "Biochemical and molecular genetic approaches to studying protein export by cyanobacteria." Thesis, University of Warwick, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384785.

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34

Manasse, Robert Samuel. "Photosystem I and cyclic transfer in Phormidium laminosum." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336741.

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35

Petitdemange, Rosine. "Chemoselective modifications of recombinant elastin-like polypeptides : tuning thermosensitivity and bioactivity." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0360/document.

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La thèse présentée porte sur la préparation de dérivés de polypeptides recombinant à base de motifs élastine (ELPs) ainsi que sur l'étude de leurs propriétés physicochimiques et biologiques. Des ELPs contenant des résidus méthionine ont été modifiés de manière chimiosélective soit en utilisant des halogénures d'alkyle ou différents époxydes, soit par oxydation des résidus méthionine. La caractérisation par RMN et par spectrométrie de masse des composés obtenus a permis de confirmer leur fonctionnalisation quantitative. L'étude de la réponse en température de ces dérivés d'ELP par des mesures d

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36

McColl, Suzzanne May. "Study on polypeptides of cyanobacterial photosystem 2." Thesis, University of Central Lancashire, 1993. http://clok.uclan.ac.uk/21003/.

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The main objective of this work was to characterize cyanobacterial PS2 polypeptides with particular respect to calcium binding. A number of cyanobacteria were studied by trypsin digestion of their thylakoid membranes which showed that using the same method of preparation some cyanobacteria produce everted thylakoid vesicles whilst others produce right sided vesicles. No direct correlation between the sidedness of the produced thylakoids and any growth or metabolic characteristic of the organithm was found. In Synechocystis 6308 a polypeptide of 27kDa , apparently unrelated to known polypeptide

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37

Wallace, T. Paul. "Extrinsic photosystem II polypeptides in Phormidium laminsoum." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335249.

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38

Miramon, Hélène. "Développement de polypeptides hélicoïdaux et activité élicitrice." Montpellier 2, 2009. http://www.theses.fr/2009MON20046.

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Le travail présenté a pour but la synthèse de polypeptides hélicoïdaux par polymérisation de N-carboxyanhydrides d'a-aminoacides. La première partie concerne le développement de polymères éliciteurs, c'est-à-dire capables de stimuler les défenses immunitaires des plantes. Ces polypeptides biodégradables et non toxiques sont constitués d'aminoacides inducteurs d'hélice a, comme l'alanine ou l'acide glutamique. Les polymères obtenus, hydrophobes et insolubles, ont été caractérisés par MALDI-TOF, électrophorèse capillaire de zone, dichroïsme circulaire et RMN. Ces composés ont été testés en utili

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39

Georgilis, Evangelos. "Engineering of Thermoresponsive Diblock Elastin-like Polypeptides." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0444.

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La thèse présentée porte sur l’ingénierie de diblocs de polypeptides à base de motifs élastine (ELPs) susceptibles de s’auto-assembler sous forme de nanoparticules après modification chimique de certains résidus. La stratégie inclue le développement de diblocs d’ELPs composés d’un bloc hydrophobe comportant l’isoleucine en position hôte, fusionné à l’extrémité N-terminale avec un bloc contenant des résidus méthionine chimiosélectivement modifiables. Des modifications du groupement thioéther permettent en effet l’hydrophilisation du segment ELP correspondant ainsi que l’introduction de groupeme

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40

Alanazi, Hamdan Noman. "Characterization of Elastin-Like Polypeptides Using Viscometry." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1311026986.

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41

Selegård, Robert. "Polypeptide functionalized gold nanoparticles for bioanalytical applications." Doctoral thesis, Linköpings universitet, Molekylär fysik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-106719.

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Detection strategies that allow for simple, rapid, cost efficient and sensitive monitoring of proteins and their interactions with biomolecules are of great importance in drug development and diagnostics. This thesis describes the development of bioanalytical applications based on the tunable self-assembly of gold nanoparticles functionalized with a de novo designed polypeptide. Strategies for protein affinity sensing and for detection of several fundamentally important biological processes have been investigated, including Zn2+-mediated coordination between polypeptides and low molecular weig

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42

Martin, Mackenzie Marie. "Synthetic polypeptide-based hydrogel systems for biomaterials." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/91120.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Chemistry, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 27-28).<br>Hydrogels formed from synthetic polypeptides generated by ring opening polymerization (ROP) of a-amino acid N-carboxyanhydrides (NCAs) present a robust material for modeling the interaction between extracellular matrix (ECM) properties and cellular phenomena. The unique properties of the polypeptide backbone allow it to fold into secondary structures and the ability to modify the side chain presents the opportunity

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43

Losik, Magdalena. "Phasenverhalten von Polypeptid-Blockcopolymeren." Phd thesis, [S.l. : s.n.], 2004. http://pub.ub.uni-potsdam.de/2004/0061/losik.pdf.

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44

Pakstis, Lisa M. "Controlled self-assembly of amphiphilic diblock copolypeptides." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 14.66 Mb., 139 p, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3200558.

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45

Gao, Yi. "Development of a novel hTERTC27 based cancer : gene therapy /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557790.

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46

Wright, Penelope A. "Mechanistic studies on the catalysis and inhibition of serine proteases." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302492.

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47

Qiu, Guang, and 邱光. "Assessment of the role of corticosterone and adiponectin in the neuroprotective effect of dietary restriction." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290604.

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48

Qiu, Guang. "Assessment of the role of corticosterone and adiponectin in the neuroprotective effect of dietary restriction." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41290604.

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49

Leuthold, Simone Denise. "Structure-function relationship of organic anion transporting polypeptides /." Zürich : ETH, 2007. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17208.

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50

Turpin, Eleanor R. "Computational studies of folding and binding of polypeptides." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13644/.

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In this thesis molecular dynamics simulations, in conjunction with the complementary methods of docking and QM-MM, are used, and further developed, to study two unusual polypeptide systems: the conformational preferences of isomers of an antibiotic peptide and the binding behaviour of a human transporter protein. The antibiotic peptides are analogues of a naturally occurring antibacterial called nisin which has a biological function dependent on the formation of five macrocyclic rings closed by a thioether bond between modified L-amino and D-amino residues. We propose analogues where the thioe

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