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Dissertations / Theses on the topic 'Polypeptides'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Aronsson, Christopher. "Tunable and modular assembly of polypeptides and polypeptide-hybrid biomaterials." Doctoral thesis, Linköpings universitet, Molekylär fysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-132949.

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Biomaterials are materials that are specifically designed to be in contact with biological systems and have for a long time been used in medicine. Examples of biomaterials range from sophisticated prostheses used for replacing outworn body parts to ordinary contact lenses. Currently it is possible to create biomaterials that can e.g. specifically interact with cells or respond to certain stimuli. Peptides, the shorter version of proteins, are excellent molecules for fabrication of such biomaterials. By following and developing design rules it is possible to obtain peptides that can self-assemb

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2

Göransson, Ulf. "Macrocyclic polypeptides from plants." Doctoral thesis, Uppsala University, Department of Medicinal Chemistry, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1956.

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<p>The aim of this work was to explore the structural and functional diversity of polypeptides that are found in plants. Expanding knowledge of simililarities between plant use of these compound and animal use promises exceptional opportunities for finding, from plant research, new structures with biomedical and biotechnological potential.</p><p>A fractionation protocol was developed and applied to many plant species, providing fractions enriched in polypeptides, amenable to chemical and biological evaluation. From one species, the common field pansy (<i>Viola arvensis</i>), a 29-amino-acid re

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3

Ng, Yuen-lam Stephanie, and 吳宛霖. "Identification of VIP, PACAP and their receptors in agnathans: insights into the ancestral origin of theligands and receptors." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45704879.

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4

Mortenson, Paul Neil. "Energy landscapes of model polypeptides." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621232.

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5

Monreal, Jorge. "Polymer Characteristics of Polyelectrolyte Polypeptides." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6326.

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Polypeptides are polymerized chains of amino acids linked covalently through peptide bonds. Polyelectrolyte polypeptides are polypeptides with electrolyte repeating groups. Several amino acids contain ionizable side chains which result in charge distributions when dissolved in aqueous solutions. This dissertation is motivated by a desire to gain knowledge of polyelectrolyte polypeptides as recent advances in chemical synthesis of polypeptides have made possible the fabrication of designed polypeptides that do not naturally occur in nature. Potential applications of newly designed polypeptides

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6

Ji, Sifan. "Analogues polypeptides intelligents de la protéine fluorescente verte." Electronic Thesis or Diss., Bordeaux, 2025. http://www.theses.fr/2025BORD0010.

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La protéine fluorescente verte (GFP) s'est imposée comme une sonde fluorescente unique qui trouve des applications dans le domaine des sciences de la vie. La découverte et le développement de la GFP ont été dûment récompensés par le prix Nobel de chimie en 2008. La protéine se compose d'un chromophore central, intégré dans une chaîne polypeptidique hélicoïdale et encapsulé dans une cage protéique. Ces dernières années, des fluorophores synthétiques analogues au chromophore de la GFP ont été développés dans le but d'imiter les propriétés de fluorescence de la protéine et de ses dérivés. Ces flu

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7

Crick, F. "Polypeptides and proteins : X-ray studies." Thesis, University of Cambridge, 2013. https://www.repository.cam.ac.uk/handle/1810/250994.

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8

Oomen, Ray. "Interaction of polypeptides with lipid bilayers." Thesis, University of Ottawa (Canada), 1988. http://hdl.handle.net/10393/5253.

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9

Ling, Roger. "Polypeptides of murine and avian pneumoviruses." Thesis, University of Warwick, 1988. http://wrap.warwick.ac.uk/55532/.

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The work described in this thesis identifies some properties of the major polypeptides of pneumonia virus of mice (PVM) and of turkey rhinotracheitis (TRT) virus. The PVM glycoproteins have been studied in particular detail while the results obtained with TRT virus provide a preliminary description of the polypeptides of this virus. Twelve major PVM specific polypeptides designated L, G1, G2, F1, N, 39K, 35K, M, 20K, 19K, 16K and 12K were identified. In addition PVM specific polypeptides designated 25K, 24K, 23K, 18K and 17K were sometimes detected. Monoclonal antibodies directed against the G

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10

Galbraith, Toby Patrick. "Biophysical studies of membrane channel polypeptides." Thesis, Birkbeck (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249171.

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11

Mullin, M. J. "Combinatorial studies on the B-loop residues of human epidermal growth factor." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273233.

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12

Smith, Dawn. "Protein distribution between cytoplasmic and thylakoid membranes of cyanobacteria." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282019.

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13

Deller, Marc Christian. "Structural studies of cytokines and cytokine receptors." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326028.

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14

Meillon, Jean Christophe. "Transport transmembranaire et auto-assemblage impliquant des peptides synthétiques modifiés." Sherbrooke : Université de Sherbrooke, 1998.

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15

McColl, Suzzanne May. "Study on polypeptides of cyanobacterial photosystem 2." Thesis, University of Central Lancashire, 1993. http://clok.uclan.ac.uk/21003/.

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The main objective of this work was to characterize cyanobacterial PS2 polypeptides with particular respect to calcium binding. A number of cyanobacteria were studied by trypsin digestion of their thylakoid membranes which showed that using the same method of preparation some cyanobacteria produce everted thylakoid vesicles whilst others produce right sided vesicles. No direct correlation between the sidedness of the produced thylakoids and any growth or metabolic characteristic of the organithm was found. In Synechocystis 6308 a polypeptide of 27kDa , apparently unrelated to known polypeptide

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16

Wallace, T. Paul. "Extrinsic photosystem II polypeptides in Phormidium laminsoum." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335249.

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17

Miramon, Hélène. "Développement de polypeptides hélicoïdaux et activité élicitrice." Montpellier 2, 2009. http://www.theses.fr/2009MON20046.

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Le travail présenté a pour but la synthèse de polypeptides hélicoïdaux par polymérisation de N-carboxyanhydrides d'a-aminoacides. La première partie concerne le développement de polymères éliciteurs, c'est-à-dire capables de stimuler les défenses immunitaires des plantes. Ces polypeptides biodégradables et non toxiques sont constitués d'aminoacides inducteurs d'hélice a, comme l'alanine ou l'acide glutamique. Les polymères obtenus, hydrophobes et insolubles, ont été caractérisés par MALDI-TOF, électrophorèse capillaire de zone, dichroïsme circulaire et RMN. Ces composés ont été testés en utili

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18

Georgilis, Evangelos. "Engineering of Thermoresponsive Diblock Elastin-like Polypeptides." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0444.

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La thèse présentée porte sur l’ingénierie de diblocs de polypeptides à base de motifs élastine (ELPs) susceptibles de s’auto-assembler sous forme de nanoparticules après modification chimique de certains résidus. La stratégie inclue le développement de diblocs d’ELPs composés d’un bloc hydrophobe comportant l’isoleucine en position hôte, fusionné à l’extrémité N-terminale avec un bloc contenant des résidus méthionine chimiosélectivement modifiables. Des modifications du groupement thioéther permettent en effet l’hydrophilisation du segment ELP correspondant ainsi que l’introduction de groupeme

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19

Alanazi, Hamdan Noman. "Characterization of Elastin-Like Polypeptides Using Viscometry." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1311026986.

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20

Leuthold, Simone Denise. "Structure-function relationship of organic anion transporting polypeptides /." Zürich : ETH, 2007. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17208.

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21

Turpin, Eleanor R. "Computational studies of folding and binding of polypeptides." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13644/.

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In this thesis molecular dynamics simulations, in conjunction with the complementary methods of docking and QM-MM, are used, and further developed, to study two unusual polypeptide systems: the conformational preferences of isomers of an antibiotic peptide and the binding behaviour of a human transporter protein. The antibiotic peptides are analogues of a naturally occurring antibacterial called nisin which has a biological function dependent on the formation of five macrocyclic rings closed by a thioether bond between modified L-amino and D-amino residues. We propose analogues where the thioe

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22

Gaskell, M. J. "Intracellular fates of microinjected precursor and mature polypeptides." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371998.

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23

Ramesh, Balasubramaniyam. "The chemical synthesis and characteriation of biomembrane polypeptides." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281777.

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24

Nigro, Giuliano. "Incorporation de la beta alanine dans des polypeptides." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLX064.

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Les cellules vivantes utilisent 20 acides α aminés canoniques lors de la synthèse ribosomale des protéines, même si dans de rares occasions, d’autres acides aminés (selenocysteine ou pyrrolysine) peuvent être utilisés. Le répertoire des acides aminés utilisables est donc assez restreint. Cela limite la possibilité de construire des protéines ayant de nouvelles propriétés. Une tendance forte dans le domaine de l’ingénierie des protéines est la construction de systèmes permettant d’incorporer des acides aminés non canoniques pendant la biosynthèse in vivo. Ces travaux ont connu d’importants succ

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25

Lucas, Paul. "Cationic polypeptides for gene delivery to eukaryotic cells." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307110.

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26

Scanlan, D. J. "Biochemical and molecular genetic approaches to studying protein export by cyanobacteria." Thesis, University of Warwick, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384785.

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27

Manasse, Robert Samuel. "Photosystem I and cyclic transfer in Phormidium laminosum." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336741.

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28

Petitdemange, Rosine. "Chemoselective modifications of recombinant elastin-like polypeptides : tuning thermosensitivity and bioactivity." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0360/document.

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La thèse présentée porte sur la préparation de dérivés de polypeptides recombinant à base de motifs élastine (ELPs) ainsi que sur l'étude de leurs propriétés physicochimiques et biologiques. Des ELPs contenant des résidus méthionine ont été modifiés de manière chimiosélective soit en utilisant des halogénures d'alkyle ou différents époxydes, soit par oxydation des résidus méthionine. La caractérisation par RMN et par spectrométrie de masse des composés obtenus a permis de confirmer leur fonctionnalisation quantitative. L'étude de la réponse en température de ces dérivés d'ELP par des mesures d

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29

Chittchang, Montakarn Johnston Thomas P. "Effect of secondary structure on paracellular transport of polypeptides." Diss., UMK access, 2004.

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Thesis (Ph. D.)--School of Pharmacy and Dept. of Chemistry. University of Missouri--Kansas City, 2004.<br>"A dissertation in pharmaceutical sciences and chemistry." Advisor: Thomas P. Johnston. Typescript. Vita. Description based on contents viewed Feb. 23, 2006; title from "catalog record" of the print edition. Includes bibliographical references (leaves 202-223). Online version of the print edition.

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30

Stark, Margareta. "Isolation and characterization of lipid-associated and neurosecretory polypeptides /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4202-1/.

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31

Leiper, Kenneth Alexander. "Beer polypeptides and their selective removal with silica gels." Thesis, Heriot-Watt University, 2002. http://hdl.handle.net/10399/444.

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32

Flint, Daniel Geoffrey. "A molecular modelling study of covalently cross-linked polypeptides." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411850.

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33

Ray, Nicola. "Genetic manipulation of photosystem two polypeptides in Chlamydomonas reinhardtii." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395045.

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34

Bishop, Cleo Lucinda. "An investigation of the small polypeptides of photosystem ll." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271720.

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35

Engler, Amanda Catherine. "Synthesis and testing of novel polypeptides for biological applications." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/62732.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2011.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Natural systems produce macromolecules that assemble into complex, highly ordered structures. In particular, proteins and peptides derived from the 20 naturally occurring amino acids are sequenced macromolecules that can fold into secondary and tertiary structures and can self assemble into quaternary structures. Through weak interactions, these ordered systems produce high-strength materials, provide physical cues to i

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36

Morey, Shannon Marie. "Development and study of synthetic polypeptides for biomaterial applications." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/82333.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.<br>Vita. Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 38-39).<br>Creating new scaffolds for cells is critical to the development of new tissue engineering techniques. In this work, the synthesis of new polypeptide systems is discussed. These systems are intended for the formation of hydrogels which can then be used as cell substrates. Attempts at using the clickable synthetic polypeptide poly(ypropargyl L-glutamate) (PPLG) to form a self-assembly amphiphilic system is discussed,

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37

Zholobko, Oksana. "Functional Colloids from Amphiphilic Polymer Assemblies and Peptides/Polypeptides." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/29963.

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The use of responsive polymers, where even minor changes in one of the macromolecular characteristics triggered by the external stimuli can cause drastic changes in the material function or performance, is widely studying area of research. Formation of the thermodynamically stable polymer-peptide colloids, such as mixed micellar assemblies or polymer-enzyme conjugates, loading capacity of the colloids, and cargo activity all depend on the macromolecular interactions within the peptide/polypeptide-polymer system. The goal of this work is to investigate interactions between range of new polymers

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38

Agut, Willy. "Conception de nano-objets adaptatifs à base de polypeptides." Thesis, Bordeaux 1, 2008. http://www.theses.fr/2008BOR12319/document.

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Les copolymères à blocs représentent de bons candidats pour des applications biomédicales, notamment pour l’encapsulation et le relargage contrôlé de médicaments. Depuis quelques années, les équipes de recherche tentent de concevoir des nanoparticules fonctionnelles « sur mesure » de façon à augmenter leur efficacité en tant que nano-vecteurs. C’est dans ce contexte que s’est s’inscrit ce travail dont le but est de concevoir des copolymères à blocs multi-stimulables en vue d’obtenir des nano-objets adaptatifs en milieu aqueux, capables d’encapsuler des molécules actives et de les relarguer de

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39

Hayward, Richard Laurence. "Inelastic neutron scattering spectroscopy of polypeptides and molecular crystals." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/21296.

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A predictive and practical theory for a fundamental biological problem - the relation between a protein's three dimensional folded form and its function - will rest on an accurate description of the potential energy surface as a function of the protein configuration, and, thereby, on an accurate description of dynamic and thermodynamic properties. A successful theory of this sort will provide the means for rational design of proteins and ligands with desirable properties. Modern computational chemistry techniques have been applied, with qualitative success, to the calculation of protein potent

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40

Ma, Jiao. "Discovery and Characterization of Novel smORF-Encoded Polypeptides (SEPs)." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:26718718.

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Peptides and small proteins have essential physiological roles including metabolism (insulin), sleep (orexin), and stress (corticotropin-releasing hormone). Recent exploration of the human genome and proteome has revealed the existence of hundreds to thousands of short open reading frames (sORFs); however, the extent to which sORFs are translated into polypeptides is unknown. Inline with the current convention, a protein-coding short ORF is defined to be a small ORF or smORF; the protein product as a smORF-encoded polypeptide is called a SEP; and a sORF or smORF upstream from an open reading f

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41

Watson, David C. (David Charles) Carleton University Dissertation Biology. "Analysis of polypeptides associated with Typula iridescent virus particles." Ottawa, 1993.

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42

Agut, Willy Lecommandoux Sébastien Taton Daniel. "Conception de nano-objets adaptatifs à base de polypeptides." S. l. : Bordeaux 1, 2008. http://ori-oai.u-bordeaux1.fr/pdf/2008/AGUT_WILLY_2008.pdf.

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43

Dauber-Osguthorpe, Pnina. "Conformation and internal motion of polypeptides : molecular dynamics simulations." Thesis, University of Bath, 1990. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252972.

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44

Pakstis, Lisa M. "Controlled self-assembly of amphiphilic diblock copolypeptides." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 14.66 Mb., 139 p, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3200558.

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45

Gao, Yi. "Development of a novel hTERTC27 based cancer : gene therapy /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557790.

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46

Wright, Penelope A. "Mechanistic studies on the catalysis and inhibition of serine proteases." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302492.

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47

Qiu, Guang, and 邱光. "Assessment of the role of corticosterone and adiponectin in the neuroprotective effect of dietary restriction." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290604.

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48

Qiu, Guang. "Assessment of the role of corticosterone and adiponectin in the neuroprotective effect of dietary restriction." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41290604.

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49

Cowie, David. "Differential induction of organic anion transporting polypeptides in rat liver." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Restricted: no access until April 24, 2020, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25707.

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50

Lundh, Ann-Christin. "The rational design of catalytically active polypeptides with supersecondary structure." Göteborg : Department of Organic Chemistry, University of Göteborg, 1995. http://catalog.hathitrust.org/api/volumes/oclc/39066015.html.

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