Relevant bibliographies by topics / Polyplexe ADN

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'Polyplexe ADN'

Author: Grafiati
Published: 4 June 2021
Last updated: 18 February 2022

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Journal articles on the topic "Polyplexe ADN"

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Lin, Martin Hsiu-Chu, Ping-Shan Lai, Li-Ching Chang, et al. "Characterization and Optimization of Chitosan-Coated Polybutylcyanoacrylate Nanoparticles for the Transfection-Guided Neural Differentiation of Mouse Induced Pluripotent Stem Cells." International Journal of Molecular Sciences 22, no. 16 (2021): 8741. http://dx.doi.org/10.3390/ijms22168741.

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Gene transfection is a valuable tool for analyzing gene regulation and function, and providing an avenue for the genetic engineering of cells for therapeutic purposes. Though efficient, the potential concerns over viral vectors for gene transfection has led to research in non-viral alternatives. Cationic polyplexes such as those synthesized from chitosan offer distinct advantages such as enhanced polyplex stability, cellular uptake, endo-lysosomal escape, and release, but are limited by the poor solubility and viscosity of chitosan. In this study, the easily synthesized biocompatible and biode
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Kalinova, Radostina, Miroslava Valchanova, Ivaylo Dimitrov, et al. "Functional Polyglycidol-Based Block Copolymers for DNA Complexation." International Journal of Molecular Sciences 22, no. 17 (2021): 9606. http://dx.doi.org/10.3390/ijms22179606.

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Gene therapy is an attractive therapeutic method for the treatment of genetic disorders for which the efficient delivery of nucleic acids into a target cell is critical. The present study is aimed at evaluating the potential of copolymers based on linear polyglycidol to act as carriers of nucleic acids. Functional copolymers with linear polyglycidol as a non-ionic hydrophilic block and a second block bearing amine hydrochloride pendant groups were prepared using previously synthesized poly(allyl glycidyl ether)-b-polyglycidol block copolymers as precursors. The amine functionalities were intro
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Plianwong, Samarwadee, Praneet Opanasopit, Tanasait Ngawhirunpat, and Theerasak Rojanarata. "Chitosan Combined with Poly-L-arginine as Efficient, Safe, and Serum-Insensitive Vehicle with RNase Protection Ability for siRNA Delivery." BioMed Research International 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/574136.

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Chitosan (CS) combined with poly-L-arginine (PLA) was formulated and evaluated for its performance to deliver siRNA to HeLa cells expressing enhanced green fluorescent protein (EGFP). Compared with the formulations using single polymer in which the polyplexes were completely formed at the weight ratio of >20 : 1 for CS/siRNA or 1 : 1 for PLA/siRNA, the combination of CS and PLA could reduce the amounts of the polymers required for the complete complexation with siRNA, thereby forming positively charged, nanosized polyplex at the weight ratio of CS/PLA/siRNA of 5 : 0.5: 1. In addition, while
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Kandasamy, Gayathri, Elena N. Danilovtseva, Vadim V. Annenkov, and Uma Maheswari Krishnan. "Poly(1-vinylimidazole) polyplexes as novel therapeutic gene carriers for lung cancer therapy." Beilstein Journal of Nanotechnology 11 (February 17, 2020): 354–69. http://dx.doi.org/10.3762/bjnano.11.26.

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The present work explores the ability of poly(1-vinylimidazole) (PVI) to complex small interfering RNA (siRNA) silencing vascular endothelial growth factor (VEGF) and the in vitro efficiency of the formed complexes in A549 lung cancer cells. The polyplex formed was found to exhibit 66% complexation efficiency. The complexation was confirmed by gel retardation assays, FTIR and thermal analysis. The blank PVI polymer was not toxic to cells. The polyplex was found to exhibit excellent internalization and escaped the endosome effectively. The polyplex was more effective than free siRNA in silencin
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Zhou, Guoyong, Yongmin Xu, Meiwan Chen, Du Cheng, and Xintao Shuai. "Tumor-penetrating peptide modified and pH-sensitive polyplexes for tumor targeted siRNA delivery." Polymer Chemistry 7, no. 23 (2016): 3857–63. http://dx.doi.org/10.1039/c6py00427j.

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Dey, Debabrata, Chiranjit Maiti, Souvik Maiti, and Dibakar Dhara. "Interaction between calf thymus DNA and cationic bottle-brush copolymers: equilibrium and stopped-flow kinetic studies." Physical Chemistry Chemical Physics 17, no. 4 (2015): 2366–77. http://dx.doi.org/10.1039/c4cp03309d.

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Liu, Shuang, Shaohui Deng, Xiaoxia Li, and Du Cheng. "Size- and Surface- Dual Engineered Small Polyplexes for Efficiently Targeting Delivery of siRNA." Molecules 26, no. 11 (2021): 3238. http://dx.doi.org/10.3390/molecules26113238.

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Though siRNA-based therapy has achieved great progress, efficient siRNA delivery remains a challenge. Here, we synthesized a copolymer PAsp(-N=C-PEG)-PCys-PAsp(DETA) consisting of a poly(aspartate) block grafted with comb-like PEG side chains via a pH-sensitive imine bond (PAsp(-N=C-PEG) block), a poly(l-cysteine) block with a thiol group (PCys block), and a cationic poly(aspartate) block grafted with diethylenetriamine (PAsp(DETA) block). The cationic polymers efficiently complexed siRNA into polyplexes, showing a sandwich-like structure with a PAsp(-N=C-PEG) out-layer, a crosslinked PCys int
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Skandalis, Athanasios, Dimitrios Selianitis, and Stergios Pispas. "PnBA-b-PNIPAM-b-PDMAEA Thermo-Responsive Triblock Terpolymers and Their Quaternized Analogs as Gene and Drug Delivery Vectors." Polymers 13, no. 14 (2021): 2361. http://dx.doi.org/10.3390/polym13142361.

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In this work, the ability of thermo-responsive poly [butyl acrylate-b-N-isopropylacrylamide-b-2-(dimethylamino) ethyl acrylate] (PnBA-b-PNIPAM-b-PDMAEA) triblock terpolymer self-assemblies, as well as of their quaternized analogs (PnBA-b-PNIPAM-b-QPDMAEA), to form polyplexes with DNA through electrostatic interactions was examined. Terpolymer/DNA polyplexes were prepared in three different amine over phosphate group ratios (N/P), and linear DNA with a 2000 base pair length was used. In aqueous solutions, the terpolymers formed aggregates of micelles with mixed PNIPAM/(Q)PDMAEA coronas and PnBA
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Valente, J. F. A., P. Pereira, A. Sousa, J. A. Queiroz, and F. Sousa. "Effect of Plasmid DNA Size on Chitosan or Polyethyleneimine Polyplexes Formulation." Polymers 13, no. 5 (2021): 793. http://dx.doi.org/10.3390/polym13050793.

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Gene therapy could be simply defined as a strategy for the introduction of a functional copy of desired genes in patients, to correct some specific mutation and potentially treat the respective disorder. However, this straightforward definition hides very complex processes related to the design and preparation of the therapeutic genes, as well as the development of suitable gene delivery systems. Within non-viral vectors, polymeric nanocarriers have offered an ideal platform to be applied as gene delivery systems. Concerning this, the main goal of the study was to do a systematic evaluation on
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Sim, Taehoon, Gayoung Park, Hyeyoung Min, et al. "Development of a gene carrier using a triblock co-polyelectrolyte with poly(ethylene imine)-poly(lactic acid)-poly(ethylene glycol)." Journal of Bioactive and Compatible Polymers 32, no. 3 (2016): 280–92. http://dx.doi.org/10.1177/0883911516671154.

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The success of gene therapy mainly depends on the carriers for effective gene delivery. A non-viral vector using a cationic block co-polyelectrolyte, PEI-PLA-PEG polyethyleneimine-poly(lactic acid)-poly(ethylene glycol)) was developed as a potential gene carrier. The cationic PEI-PLA-PEG showed less toxicity compared to PEI and formed a gene nanocomplex (termed polyplex) by interaction with plasmid DNA or small interference RNA. The polyplex showed smaller particle size and greater positive zeta potential by increasing the high polymer nitrogen/DNA phosphate ratio. The polyplex with a nitrogen
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Dissertations / Theses on the topic "Polyplexe ADN"

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Le, Bohec Maël. "PEGylated cationic polyacrylates for transfection : synthesis, characterization, DNA complexation and cytotoxicity." Thesis, Le Mans, 2017. http://www.theses.fr/2017LEMA1027/document.

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Le développement de la thérapie génique dépend des systèmes utilisés pour le transport de gènes vers les cellules eucaryotes. Les systèmes à base de virus sont les plus efficaces. Cependant, il est urgent de trouver une alternative à de tels systèmes viraux pathogènes et oncogènes. Les polymères cationiques sont des vecteurs synthétiques prometteurs ; toutefois, une question cruciale reste en suspens : quelle structure de polymère cationique visée pour une efficacité de transfection élevée et une faible cytotoxicité ? Face à ce questionnement scientifique, de nouveaux polymères cationiques off
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Book chapters on the topic "Polyplexe ADN"

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"Polyplexes." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_13232.

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Wagner, Ernst, and Kurosh Ameri. "Receptor-Targeted Polyplexes." In Gene and Cell Therapy. CRC Press, 2003. http://dx.doi.org/10.1201/9780824758608.ch13.

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Rafael, Diana, Fernanda Andrade, Alexandra Arranja, Sofia Luís, and Mafalda Videira. "Lipoplexes and Polyplexes: Gene Therapy." In Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Taylor & Francis, 2015. http://dx.doi.org/10.1081/e-ebpp-120050058.

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Rafael, Diana, Fernanda Andrade, Alexandra Arranja, Sofia Luís, and Mafalda Videira. "Lipoplexes and Polyplexes: Gene Therapy." In Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. CRC Press, 2017. http://dx.doi.org/10.1081/e-ebppc-120050058.

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Philipp, Alexander, and Ernst Wagner. "Receptor-Targeted Polyplexes for DNA and siRNA Delivery." In Gene and Cell Therapy. CRC Press, 2008. http://dx.doi.org/10.1201/9780849387999.ch15.

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Beckert, Linda, Alexander Philipp, and Ernst Wagner. "Receptor-Targeted Polyplexes for pDNA and siRNA Delivery." In Gene and Cell Therapy. CRC Press, 2015. http://dx.doi.org/10.1201/b18002-15.

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Iwamoto, Noriyuki, and Mariko Hrada-Shiba. "Intratracheal Gene Transfer Using Polyplex Nanomicelles and Their Application to Cardiology." In Nanomedicine and the Cardiovascular System. Science Publishers, 2011. http://dx.doi.org/10.1201/b11401-18.

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Conference papers on the topic "Polyplexe ADN"

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D’Andrea, Cosimo, Andrea Bassi, Paola Taroni, Daniele Pezzoli, Alessandro Volonterio, and Gabriele Candiani. "Study of cationic polymer/DNA complex (polyplex) formation by time-resolved fluorescence spectroscopy." In Bio-Optics: Design and Application. OSA, 2011. http://dx.doi.org/10.1364/boda.2011.bwc5.

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Marzal, Jefri, Hong Xie, and Chun Che Fung. "An algorithm for splitting an orthogonal polyhedron with an orthogonal polyplane." In 2011 International Conference on Uncertainty Reasoning and Knowledge Engineering (URKE). IEEE, 2011. http://dx.doi.org/10.1109/urke.2011.6007857.

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Ohgidani, Masahiro, Koichi Furugaki, Shinkai Kentaro, et al. "Abstract A59: Block/homo polyplex micelle-based GM-CSF gene therapy via intraperitoneal administration elicits antitumor immunity against peritoneal dissemination and exhibits safety potentials in mice and monkeys." In Abstracts: AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; December 2-5, 2012; Miami, FL. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.tumimm2012-a59.

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Reports on the topic "Polyplexe ADN"

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Veleva-Kostadinova, Emilia, Ivaylo Dimitrov, Natalia Toncheva-Moncheva, Christo Novakov, and Stanislav Rangelov. Effect of PreparationConditions on the Structure of Polyplex Particles of Thermally Sensitive Poly(L-lysine)-based Copolymers and DNA. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, 2018. http://dx.doi.org/10.7546/crabs.2018.08.04.

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Journal articles
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