Relevant bibliographies by topics / Polysome profiling

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Polysome profiling'

Author: Grafiati
Published: 4 June 2021
Last updated: 12 February 2022

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Journal articles on the topic "Polysome profiling"

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Masek, Tomas, Edgar del Llano, Lenka Gahurova, et al. "Identifying the Translatome of Mouse NEBD-Stage Oocytes via SSP-Profiling; A Novel Polysome Fractionation Method." International Journal of Molecular Sciences 21, no. 4 (2020): 1254. http://dx.doi.org/10.3390/ijms21041254.

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Meiotic maturation of oocyte relies on pre-synthesised maternal mRNA, the translation of which is highly coordinated in space and time. Here, we provide a detailed polysome profiling protocol that demonstrates a combination of the sucrose gradient ultracentrifugation in small SW55Ti tubes with the qRT-PCR-based quantification of 18S and 28S rRNAs in fractionated polysome profile. This newly optimised method, named Scarce Sample Polysome Profiling (SSP-profiling), is suitable for both scarce and conventional sample sizes and is compatible with downstream RNA-seq to identify polysome associated
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Liang, Shuo, Hermano Martins Bellato, Julie Lorent, et al. "Polysome-profiling in small tissue samples." Nucleic Acids Research 46, no. 1 (2017): e3-e3. http://dx.doi.org/10.1093/nar/gkx940.

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Bronson, Michael W., Sara Hillenmeyer, Richard W. Park, and Alexander S. Brodsky. "Estrogen Coordinates Translation and Transcription, Revealing a Role for NRSF in Human Breast Cancer Cells." Molecular Endocrinology 24, no. 6 (2010): 1120–35. http://dx.doi.org/10.1210/me.2009-0436.

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Abstract Posttranscriptional regulation may enhance or inhibit estrogen transcriptional control to promote proliferation of breast cancer cells. To understand how transcriptome and translational responses coordinate to drive proliferation, we determined estrogen’s global and specific effects on translation regulation by comparing the genome-wide profiles of total mRNA, polysome-associated mRNA, and monosome-associated mRNAs in MCF-7 cells after stimulation by 1 h of 10 nm 17β-estradiol (E2). We observe three significant, novel findings. 1) E2 regulates several transcripts and pathways at the t
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Lacsina, Joshua R., Gregory LaMonte, Christopher V. Nicchitta, and Jen-Tsan Chi. "Polysome profiling of the malaria parasite Plasmodium falciparum." Molecular and Biochemical Parasitology 179, no. 1 (2011): 42–46. http://dx.doi.org/10.1016/j.molbiopara.2011.05.003.

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Seimetz, Joseph, Waqar Arif, Sushant Bangru, Mikel Hernaez, and Auinash Kalsotra. "Cell-type specific polysome profiling from mammalian tissues." Methods 155 (February 2019): 131–39. http://dx.doi.org/10.1016/j.ymeth.2018.11.015.

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Ramirez, Oscar, Anil Kesarwani, Gupta Abhishek, Alex C. Minella, and Manoj M. Pillai. "Integrative Analysis of RNA-Interactome and Translatome Reveal Functional Targets of MSI2 in Myeloid Leukemia." Blood 128, no. 22 (2016): 1881. http://dx.doi.org/10.1182/blood.v128.22.1881.1881.

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Abstract Musashi 2 (MSI2) is an RNA binding protein (RBP) that regulates asymmetric cell division and cell fate of several cell types including hematopoietic stem and progenitor cells. MSI2 was recently shown to be transcriptionally up-regulated in aggressive myeloid leukemia including chronic myelogenous leukemia in blast crisis (CML-BC) and acute myeloid leukemia (AML). Loss-of-function studies have confirmed an important role for MSI2 in the aggressive biology of these leukemia, but the precise molecular mechanisms remain undefined. MSI2 is thought to bind to the 3' untranslated region (3'U
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Lupinacci, Fernanda Cristina Sulla, Hellen Kuasne, Martin Roffé, et al. "Polysome Profiling of a Human Glioblastoma Reveals Intratumoral Heterogeneity." International Journal of Molecular Sciences 20, no. 9 (2019): 2177. http://dx.doi.org/10.3390/ijms20092177.

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Glioblastoma (GBM) is one of the most aggressive cancers, with median survival of less than 2 years. Despite of considerable advance in molecular classification of GBMs, no improvements in therapy have been described. The scenario is further complicated by tumor heterogeneity and the relationship among genetic, transcriptional and functional findings. Classically, gene expression has been evaluated by steady-state mRNA, however, this does not take translational control into consideration, which contributes considerably to the composition of the proteome. In this study, we evaluated the transcr
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Firmino, Alexandre Augusto Pereira, Michal Gorka, Alexander Graf, et al. "Separation and Paired Proteome Profiling of Plant Chloroplast and Cytoplasmic Ribosomes." Plants 9, no. 7 (2020): 892. http://dx.doi.org/10.3390/plants9070892.

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Conventional preparation methods of plant ribosomes fail to resolve non-translating chloroplast or cytoplasmic ribosome subunits from translating fractions. We established preparation of these ribosome complexes from Arabidopsis thaliana leaf, root, and seed tissues by optimized sucrose density gradient centrifugation of protease protected plant extracts. The method co-purified non-translating 30S and 40S ribosome subunits separated non-translating 50S from 60S subunits, and resolved assembled monosomes from low oligomeric polysomes. Combining ribosome fractionation with microfluidic rRNA anal
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Liu, Lichao, J. Yuyang Lu, Fajin Li, et al. "IDH1 fine-tunes cap-dependent translation initiation." Journal of Molecular Cell Biology 11, no. 10 (2019): 816–28. http://dx.doi.org/10.1093/jmcb/mjz082.

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Abstract The metabolic enzyme isocitrate dehydrogenase 1 (IDH1) catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG). Its mutation often leads to aberrant gene expression in cancer. IDH1 was reported to bind thousands of RNA transcripts in a sequence-dependent manner; yet, the functional significance of this RNA-binding activity remains elusive. Here, we report that IDH1 promotes mRNA translation via direct associations with polysome mRNA and translation machinery. Comprehensive proteomic analysis in embryonic stem cells (ESCs) revealed striking enrichment of ribosom
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Grech, Godfrey, Montserrat Balzquez-Domingo, Andreas Kolbus, et al. "The Regulation of mRNA Translation Controls the Balance between Expansion and Differentiation of Erythroid Progenitors." Blood 104, no. 11 (2004): 462. http://dx.doi.org/10.1182/blood.v104.11.462.462.

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Abstract Erythroid progenitors can be expanded in vitro in the presence of erythropoietin (Epo), stem cell factor (SCF) and dexamethasone, while they differentiate to enucleated erythrocytes in presence of Epo only. Our study aims to identify (i) signaling pathways that control expansion of erythroid progenitors and (ii) genes regulated by these signaling pathways. Since SCF strongly activates phosphotidylinositol 3 kinase (PI3K) and inhibition of PI3K with LY294002 induces terminal differentiation of erythroid progenitors under Epo and SCF stimulation, SCF seems to enhance renewal divisions o
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Dissertations / Theses on the topic "Polysome profiling"

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Blin-Gonthier, Juliana. "Regulation of mRNA translation during the inflammatory response in murine macrophages." Thesis, Lyon, 2020. http://www.theses.fr/2020LYSEN032.

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La régulation dynamique de la synthèse des protéines en fonction des besoins de la cellule facilite son adaptation face aux fluctuations de l’environnement. Malgré l’importance de la régulation de la traduction au cours du processus d’expression des gènes, l’impact de ce mécanisme sur des processus biologiques fondamentaux, comme la mise en place d’une réponse immunitaire, reste mal compris. Grâce au développement de nouvelles technologies basées sur l’utilisation du séquençage à haut débit, comme le ribosome profiling, il est désormais possible d’étudier en détails la façon dont la synthèse d
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Nguyen, Tan-Trung. "Identifier des gènes nucléaires liés au maintien de l’ADN mitochondrial chez le champignon filamenteux Podospora anserina." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112014.

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Les mitochondries jouent un rôle majeur dans le métabolisme de l'ATP des cellules eucaryotes. Le maintien de l'ADN mitochondrial (ADNmt) est fondamental pour la production d'énergie chez les organismes aérobie stricte. De grandes délétions de ADNmt sont à l'origine d'anomalies mitochondriales entrainant des maladies chez l'homme. Plusieurs gènes nucléaires impliqués dans le métabolisme de l’ADNmt ont été identifiés et caractérisés chez l'homme. Cependant, l’ensemble des facteurs et leurs activités requis pour le maintien de l'ADNmt reste largement inconnu. L'identification de ces facteurs et l
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Costache, Vlad. "Régulation traductionnelle en réponse à la fécondation et en conditions perturbées dans l'embryon d'oursin." Phd thesis, Université Rennes 1, 2012. http://tel.archives-ouvertes.fr/tel-00706548.

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La traduction est une étape critique de la régulation de l'expression des gènes. Chez l'oursin, la fécondation induit une augmentation de la synthèse protéique, qui dépend essentiellement de la traduction d'ARN messagers maternels. Cette synthèse protéique est indispensable au déroulement des cycles cellulaires du développement précoce. Le développement embryonnaire de l'oursin constitue ainsi un modèle de choix pour étudier la régulation de la traduction. Dans le cadre de cette thèse, le contrôle de la traduction a été étudié chez l'oursin dans deux situations : le contexte physiologique de l
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Tréfier, Aurelie. "Le traductome induit par le récepteur FSH et l'implication des B-arrestines dans le contrôle de la traduction des ARNm 5' TOP." Thesis, Tours, 2017. http://www.theses.fr/2017TOUR4040.

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La FSH est une des hormones clés qui régule la reproduction chez les mammifères. Chez le mâle, elle cible les cellules de Sertoli, qui expriment le RFSH. La cellule de Sertoli a un rôle trophique important pour le bon développement de la spermatogenèse. Dans cette thèse, nous avons établi le premier traductome, c’est-à-dire l’ensemble des ARNm en cours de traduction, dépendant du RFSH. La traduction de certains ARNm significativement modulés par la FSH exercerait un rétrocontrôle sur la signalisation FSH-dépendante. L’analyse du protéome nous a permis de valider ce traductome au niveau systémi
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Book chapters on the topic "Polysome profiling"

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Zuccotti, Paola, and Angelika Modelska. "Studying the Translatome with Polysome Profiling." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3067-8_4.

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Kudla, Marek, and Fedor V. Karginov. "Measuring mRNA Translation by Polysome Profiling." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3591-8_11.

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Jin, Hyun Yong, and Changchun Xiao. "An Integrated Polysome Profiling and Ribosome Profiling Method to Investigate In Vivo Translatome." In Methods in Molecular Biology. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7514-3_1.

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Bajak, Kathrin, and Christine Clayton. "Polysome Profiling and Metabolic Labeling Methods to Measure Translation in Trypanosoma brucei." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0294-2_7.

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Krawczak, Karolina. "Chapter 3. The role of verb polysemy in constructional profiling." In Constructional Approaches to Language. John Benjamins Publishing Company, 2021. http://dx.doi.org/10.1075/cal.29.03kra.

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Conference papers on the topic "Polysome profiling"

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Kabardaeva, K. V., O. N. Mustafaev, I. V. Deineko, A. V. Suhorukova, and I. V. Goldenkova-Pavlova. "Finding of regulatory codes in 5`-UTR of A. thaliana mRNAs by polysome profiling method." In 2nd International Scientific Conference "Plants and Microbes: the Future of Biotechnology". PLAMIC2020 Organizing committee, 2020. http://dx.doi.org/10.28983/plamic2020.107.

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The polysome profiling method was used to separate mRNAs depending on their loading by ribosomes into polysomal and monosomal fractions. Pools separation of such mRNAs and analysis of transcripts (mRNAs) which are associated with each mRNA pool due to RNA sequencing allowed to get an idea of the translational efficiency of individual mRNAs. Moreover, subsequent in silico analysis make possible searching of regulatory contexts in the 5'-UTR of plant A. thaliana, which may be potentially important for efficient translation of mRNA.
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Vassalakis, Julia A., Stenio C. Zequi, Stephania M. Bezerra, et al. "Abstract 2441: Polysome profiling suggests VHL-dependent translational control in clear cell renal cell carcinoma." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2441.

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Hajj, Glaucia N., Fernanda C. Lupinacci, Martin Roffe, et al. "Abstract 2439: Transcriptome-wide polysome profiling of glioblastomas identifies molecular subgroups with impact in survival and treatment." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2439.

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