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Dissertations / Theses on the topic 'Pontile'

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Published: 4 June 2021
Last updated: 1 February 2022

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1

Cunningham, Dawn K. "(Re-)constructing a passion the pontile of Modena Cathedral /." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1058618800.

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Thesis (Ph. D.)--Ohio State University, 2003.
Title from first page of PDF file. Document formatted into pages; contains xxi, 298 p.; also includes graphics Includes bibliographical references (p. 275-298). Available online via OhioLINK's ETD Center
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2

Cunningham, Dawn K. "(Re-)constructing a passion: the pontile of Modena Cathedral." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1058618800.

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3

Conconi, Federico. "Progettazione e calcoli per un pontile ad uso ricreativo in località Riccione." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amslaurea.unibo.it/1734/.

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4

D’Antonio, Francesco. "Progetto di un pontile turistico a Riccione (RN) con valutazione della sollecitazione ondosa e modalità d'accosto." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amslaurea.unibo.it/1730/.

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5

Grigoletto, Aude. "Rôle de la reptine dans le carcinome hépatocellulaire." Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR21946/document.

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Le carcinome hépatocellulaire (CHC) est le principal cancer primitif du foie et est associé à un très mauvais pronostic. Notre équipe a mis en évidence que la Reptine et la Pontine, des AAA+ ATPases homologues, sont surexprimées dans le CHC par rapport au foie non tumoral. Au cours de ce travail de thèse, j’ai contribué à démontrer que l’extinction de la Reptine par l’induction de shRNA suffit à arrêter la croissance de tumeurs déjà établies, et même à induire leur régression dans des xénogreffes chez la souris. Ces résultats encourageants suggèrent que la Reptine pourrait être une cible thérapeutique dans le CHC. L’utilisation de siRNA en thérapeutique n’étant pas envisageable actuellement, il parait plus pertinent de tenter de cibler la Reptine via son activité ATPase. Le principal objectif de ma thèse était donc de déterminer l’implication de l’activité ATPase de la Reptine pour ses propriétés oncogéniques dans le CHC. Nos résultats ont montré que des mutants inactifs de la Reptine (D299N et E300G) ont un effet dominant négatif et ne sont pas capables de complémenter l’absence de la Reptine endogène, ce qui conduit à une diminution significative de la croissance des cellules HuH7 et Hep3B, et à une induction de l’apoptose. Ceci indique que l’activité ATPase de la Reptine est nécessaire pour la croissance et la survie des cellules de CHC. Enfin, grâce à une étude transcriptomique, nous avons identifié de nouveaux gènes dont l’expression est régulée par la Reptine et/ou la Pontine. Parmi ces gènes, certains pourraient être impliqués dans les fonctions oncogéniques de la Reptine et/ou de la Pontine dans le CHC. Finalement, ce travail a permis de mettre en évidence l’implication de l’activité ATPase de la Reptine, et d’apporter des éléments permettant de mieux comprendre le mécanisme d’action de la Reptine dans le CHC
Hepatocellular carcinoma (HCC) is the main primary cancer of the liver and is often associated with poor prognosis. Our team has demonstrated that Reptin and Pontin, two AA+ ATPases, are overexpressed in HCC compared to normal liver. Moreover this overexpression is also associated with poor prognosis. In the course of my PhD, I demonstrated that shRNA-mediated silencing of Reptin is sufficient to inhibit tumor growth and even can promote their regression in xenografted mice. These encouraging results suggest that Reptin might represent a novel therapeutic target in HCC. As the use of siRNA as therapeutic tools is still debated, the targeting of Reptin enzymatic activity might represent a more relevant approach to impair its functions. To this end I first proposed to determine the involvement of Reptin ATPase activity in HCC oncogenesis. My results show that ATPase inactive Reptin mutants (D299N and E300G) play dominant negative roles toward Reptin functions and are unable to complement for the depletion of endogenous Reptin, thereby leading to a significant decrease of cell growth and to a significant increase of apoptosis in HuH7 and Hep3B cells. These results show that Reptin’s ATPase activity is necessary for HCC cell growth and survival. Moreover, using a transcriptomic approach that compared gene expression upon siRNA-mediated Reptin or Pontin silencing, we identified specific genes whose expression is under the control of those proteins and whose functions might provide mechanistic explanation to Reptin’s involvement in HCC. Collectively, the results obtained during my PhD thesis have characterized the contribution of Reptin ATPase activity to HCC growth and development and might represent a founding step in the understanding of Reptin’s biology in cancer development
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6

Tarozzi, Mirco. "Caratterizzazione dinamica di ponti in calcestruzzo: analisi del ponte Bacchelli a Bologna." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017.

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Il presente lavoro di tesi viene svolto all’interno del “Progetto SHAPE – Predicting Strength Changes in Bridges from Frequency Data Safety, Hazard, and Poly-harmonic Evaluation”, progetto che fa parte del programma “ERA-NET Plus Infravation 2014 Call” finanziato dalla Comunità Europea e che si occupa della valutazione dello stato di sicurezza dei ponti esistenti attraverso la definizione di un sistema di acquisizione e monitoraggio dei parametri modali al fine di percepirne le variazioni. L’elaborato si compone principalmente di due parti, la prima introduce il monitoraggio, le principali tecniche di identificazione del danno e riprende alcune delle principali nozioni inerenti all’analisi del segnale e alla dinamica delle strutture; la seconda parte, invece, si focalizza principalmente sull’applicazione dell’analisi nel dominio delle frequenze di segnali acquisiti sperimentalmente mediante la tecnica di analisi modale operazionale di tipo Output-Only. La caratterizzazione dinamica viene condotta su due ponti modello, realizzati in scala 1:4 presso il laboratorio LISG della Scuola di Ingegneria e Architettura di Bologna, e per un ponte esistente, il ponte R. Bacchelli, situato sempre a Bologna. L’acquisizione dei dati accelerometrici si è operata a seguito di un’eccitazione impulsiva nel caso dei modelli in scala, e di un’eccitazione random, quale quella del traffico, per quanto riguarda il ponte esistente in condizione di esercizio, l’elaborazione dei dati è stata effettuata mediante tecniche di analisi del segnale in ambiente Matlab, i cui risultati sono stati poi confrontati con quelli ottenuti da modelli FEM realizzati con il software Straus7 ed infine si è proceduto ad un’analisi critica dei risultati.
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7

Mussoni, Taron. "Rimini. Un nuovo fronte mare. Riqualificazione del lungomare e proposta di un centro polifunzionale." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/8406/.

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Il progetto di tesi si pone come obiettivo la riqualificazione urbana del fronte mare della città di Rimini e la progettazione di un nuovo centro culturale polifunzionale. La costruzione di nuovi margini urbani, viene qui proposta secondo una reinterpretazione di un carattere tipicamente funzionale delle città di costa del litorale adriatico: la proiezione della funzione urbana oltre la linea di costa, con la costruzione di moli oltre l’edificato. “La città allunga la mano nell’acqua.” La tesi riprende questo aspetto di tipicità e propone una serie di “nuovi moli”, strutture polifunzionali destinate a incentivare quale risorsa fruitiva per il pubblico, stanziale o turistico, il rapporto col mare Adriatico. Anche in relazione a queste “proiezioni” oltre il litorale marino la tesi ha analizzato le forme dell’architettura di ultima generazione, cercando di recepirne i significati espressi attraverso la definizione formale; da qui parte il percorso della formulazione compositiva espressa nelle tavole grafiche, nelle quali si sottolinea il rapporto funzionale in relazione alla nova forma urbis e alla ricaduta sul nuovo assetto ambientale. E’, in sintesi, l’accettabilità di questo e dell’integrazione paesaggistica che la tesi vuole sostenere, attraverso il lungo percorso analitico e progettuale affrontato.
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8

Brighenti, Gabriele. "Modellazione ed analisi di ponti ad arco in muratura: il ponte ferroviario sul fiume Reno." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amslaurea.unibo.it/1974/.

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9

Cornélis, Jean-Philippe. "Homo Pontifex et Pontifex Oppositorum : créativité, imaginaire et heuristique." Paris 1, 2003. http://www.theses.fr/2003PA010501.

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La thèse " Homo Pontifex et Pontifex Oppositorum, Créativité, Imaginaire et Heuristique" se propose d'analyser les trois domaines de pertinence de la créativité, de l'imaginaire et de l'heuristique (ou science de la découverte) à partir de la notion de construction et/ou de découverte du sens dans l'anthropologie et l'épistémologie. Ces trois notions de sens sont décrites comme : celle du domaine de la structure de la personnalité (du sujet, du moi, de l'individu) comme non encore immergé dans le tissu social: cette structure est décrite dans la thèse par le mythe de Narcisse : celle du domaine de la structure sociale ayant trait aux valeurs, codes, lois et règlements érigés par cette société pour organiser la " civilité " et le vivre ensemble : cette structure est décrite dans la thèse par le mythe de Babel ; celle du domaine de l'approche technico-scientifique des sciences dites exactes et ayant trait à l'élaboration de codes et de lois scientifiques et techniques conçus pour mettre en application les lois de la nature: cette structure est décrite dans la thèse par le mythe d'Icare.
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10

Grossrubatscher, Florian. "Modellazione e analisi di ponti ad arco in muratura: il caso del ponte di Bagno di Piano." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amslaurea.unibo.it/62/.

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La Tesi tratta della modellazione e dell'analisi di ponti ad arco in muratura. In particolare è stato studiato il caso del vecchio ponte di Bagno di Piano, sito al km 14 della S.P. 18 "Palludese" in comune di Sala Bolognese in Provincia di Bologna. L’obiettivo della Tesi di Laurea è duplice, nel senso che da un lato si cerca di risalire alle probabili cause del crollo e, dall’altra si intende mettere a punto un quadro operativo per l’analisi strutturale di ponti ad arco in muratura.
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11

Corgne, Eugène. "Pontivy et son district pendant la Révolution : 1789-germinal an V /." Pontivy : la Ville, 1988. http://catalogue.bnf.fr/ark:/12148/cb349998341.

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12

Elkaïm, Judith. "Drug design in silico : criblage virtuel de protéines à visée thérapeutique." Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14444/document.

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Les processus qui mènent à la découverte de nouveaux médicaments sont longs et fastidieux, et les taux de succès sont relativement faibles. L’identification de candidats par le biais de tests expérimentaux s’avère coûteuse, et nécessite de connaître en profondeur les mécanismes d'action de la protéine visée afin de mettre en place des essais efficaces. Le criblage virtuel peut considérablement accélérer ces processus en permettant une évaluation rapide de chimiothèques de plusieurs milliers de molécules afin de déterminer lesquelles sont les plus susceptibles de se lier à une cible. Ces dernières années ont ainsi été témoins de quelques success stories dans ce domaine.Le premier objectif de ce travail était de comparer différents outils et stratégies couramment utilisés dans le criblage virtuel “structure-based”, puis de les appliquer à des cibles protéiques à visée thérapeutique, en particulier dans le cadre du cancer.La protéine kinase GSK3 et un test set de ligands connus ont servi de modèle pour différentes études méthodologiques ayant pour but d’évaluer les programmes de docking et de scoring à notre disposition. En particulier, l’utilisation de plusieurs structures relaxées du récepteur ou l’insertion de torsions sur certains résidus du site actif pendant le docking ont permis d’évaluer l’influence de la flexibilité de la protéine. L’utilité et la pertinence d’outils permettant de générer automatiquement les structures 3D des ligands et de méthodes de consensus scoring ont également été étudiées.Un criblage virtuel de la Pontine, une ATPase impliquée dans la croissance tumorale pour laquelle aucun inhibiteur n’était connu, a permis la sélection de candidats issus de banques de données commerciales. Ces molécules ont été testées dans un essai enzymatique par le biais d’une collaboration, et quatre d’entre elles se sont révélées capable d’inhiber l’activité ATPase de la Pontine. Le criblage de bases de ligands synthétisés et imaginés dans l’équipe a également fourni un inhibiteur original. Au contraire, l’étude de la sPLA2-X humaine, une phospholipase dont l’activité catalytique est dépendante d’un atome de Ca2+ localisé au sein du site actif, a montré les limites de nos outils de docking qui n’ont pas été capables de gérer cet ion métallique et mis en évidence la nécessité de mettre en place d’autres outils
The process of drug discovery is long and tedious. Besides, it is relatively inefficient in terms of hit rate. The identification of candidates through experimental testing is expensive and requires extensive data on the mechanisms of the target protein in order to develop efficient assays. Virtual screening can considerably accelerate the process by quickly evaluating large databases of compounds and determining the most likely to bind to a target. Some success stories have emerged in the field over the last few years.The objectives of this work were first, to compare common tools and strategies for structure-based virtual screening, and second, to apply those tools to actual target proteins implied notably in carcinogenesis.In order to evaluate the docking and scoring programs available, the protein kinase GSK3 and a test set of known ligands were used as a model to perform methodological studies. In particular the influence of the flexibility of the protein was explored via relaxed structures of the receptor or the insertion of torsions on the side chains of residues located in the binding site. Studies concerning the automatic generation of 3D structures for the ligands and the use of consensus scoring also provided insights on the usability of these tools while performing a virtual screening.Virtual screening of the human protein Pontin, an ATPase implied in tumor cell growth for which no inhibitors were known, allowed the prioritization of compounds from commercial databases. These compounds were tested in an enzymatic assay via a collaboration, and led to the identification of four molecules capable of inhibiting the ATPase activity of Pontin. Additional screens of in-house oriented databases also provided at least one innovative inhibitor for this protein. On the contrary, a study of the human PLA2-X, a phospholipase that requires a Ca2+ atom to bind to its active site in order to catalyze the hydrolysis of its substrate, revealed the limits of our docking tools that could not handle the metal ion and the need for new tools
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13

Amar, Jean-Michel. "Myélinolyse centro pontine et hyponatrémie: à propos d'une observation." Montpellier 1, 1988. http://www.theses.fr/1988MON11130.

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14

Barat, Claire. "Sinope dans son environnement pontique." Bordeaux 3, 2006. http://www.theses.fr/2006BOR30068.

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La cité de Sinope se trouve au centre de la côte méridionale de la mer Noire. Le travail vise à déterminer quel fut le rayonnement de la cité de Sinope dans l’Antiquité à la lumière des sources littéraires, mais aussi épigraphiques, numismatiques, archéologiques et amphorologiques. La première partie consiste en une présentation de Sinope, à travers les récits de voyageurs (XVIIe-XIXe s. ), puis les fouilles archéologiques menées dans la ville moderne de Sinop et sur son territoire au XXe s. La seconde partie concerne l’histoire politique de Sinope, de sa fondation, au VIIe s. Av. J. -C. , à l’époque romaine. A l’époque classique, Sinope fut soumise à l’Empire perse, mais fut aussi parfois relativement indépendante, quand le contrôle central se relâchait. Elle bénéficia de sa position périphérique aux conquêtes d’Alexandre le Grand et connut ainsi l’indépendance et la prospérité à l’époque hellénistique. En 183, elle fut conquise par Pharnace du Pont, et devint ensuite la capitale du royaume du Pont. Sa conquête fut particulièrement recherchée lors des Guerres Mithridatiques : elle fut prise par Lucullus en 70 et devint une colonie césarienne en 45 av. J. -C. A l’époque romaine, la documentation épigraphique permet d’étudier la vie municipale de Sinope. La troisième partie traite du rayonnement de Sinope. A travers l’étude des ressources naturelles, de la circulation des monnaies, des hommes et des amphores de Sinope, il est possible de définir ce rayonnement. Le dernier chapitre se concentre sur les cultes à Sinope et montre qu’ils furent particulièrement originaux à l’époque romaine (culte de Sarapis)
The city of Sinope lies on the Southern Black Sea Coast. This work’s aim is to show the influence of the city during the Antiquity, trough litterary, numistatic, epigraphic, archaeologic and amphorologic sources. The first part is a presentation of Sinope through travellers’accounts (XVIIth-XIXth Centuries) and archaeaological excavations in modern Sinop and its territory in the XXth Century. The second part is about the political history of Sinope, from its foundation in the VIIth Century B. C. To the Roman times. In Classical period, Sinope was a subject of the Persian Empire, but was also, from times to times, quite independent, when the central power was too weak. Thanks to its peripherical position, it escaped Alexander’s conquests and became independent and wealthy in the Hellenistic period. In 183, it was conquered by Pharnaces of Pontus, and became later the capital of the Pontic Kingdom. Its conquest was particularly important during the Mithridatic wars : it was taken by Lucullus in 70 and became a Cesarian colony in 45 B. C. In Roman period, thanks to the epigraphic documentation, it is possible to study the municipal life of Sinope. The third part is about the extension of Sinope. Through the study of the natural ressources, the circulation of coins, men and amphoras, it is possible to determine this extension. The last chapter is about the cults in Sinope and shows that they were particularly original in the Roman period (Sarapis’cult)
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15

Furnish, Robin. "Evaluating Immune Modulatory Therapeutic Strategies for Diffuse Intrinsic Pontine Glioma." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595849080346532.

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16

Vittori, Giulio. "Gestire la manutenzione dei ponti: dalle prove in sito alla valutazione della capacità portante Applicazione al ponte sul fiume Lamone a Ravenna​." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/12892/.

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La gestione e la manutenzione dei ponti in Italia è per legge affidata all'Ente proprietario; tuttavia non sempre questi riesce a far fronte, a causa della scarsità di risorse alla manutenzione di tutte le opere realizzati. Questa tesi illustra una metodologia completa che, partendo dall'ispezione visiva del manufatto permette l'individuazione delle situazioni di maggior degrado. L'utilizzo di prove in sito permette quindi la determinazione delle caratteristiche meccaniche dei materiali; queste a loro volta sono inserite in un modello numerico calibrato che simula il reale comportamento della struttura sotto carico. I risultati numerici consentono l'esecuzione di verifiche di resistenza nelle sezioni maggiormente sollecitate e il confronto delle deformazioni teoriche con quelle sperimentali ottenute da prove di carico statiche. Il metodo permette quindi, sulle basi dei risultati sperimentali e numerici la certificazione della capacità portante dell'opera, lasciando all'Ente la possibilità di stimare accuratamente i costi di risanamento.
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17

Poirier, Yann, and Yann Poirier. "Utilisation préopératoire du ballon intra-aortique avant pontage aorto-coronarien : impacts hémodynamiques et cliniques." Master's thesis, Université Laval, 2019. http://hdl.handle.net/20.500.11794/36960.

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Tableau d'honneur de la Faculté des études supérieures et postdoctorales, 2019-2020
Tableau d'honneur de la Faculté des études supérieures et postdoctorales, 2019-2020
La maladie coronarienne athérosclérotique représente la première cause de mortalité à travers le monde. De nombreux traitements existent dans le but de réduire son incidence et sa symptomatologie. Parmi ceux-ci, la chirurgie de revascularisation par pontage aorto-coronarien demeure le plus efficace, mais les risques qui lui sont associés sont importants. Le ballon intra-aortique est un outil mécanique de support à la circulation utilise en cas d’instabilité hémodynamique, notamment en contexte de pontage aorto-coronarien. Il agit en augmentant la perfusion coronarienne en diastole et en réduisant la postcharge ventriculaire gauche en systole. Son utilisation est encadrée dans plusieurs situations, mais les évidences entourant sa pratique demeurent faibles et controversées. Ce mémoire avait donc comme objectif l’évaluation de l’impact de l’installation préoperatoire d’un ballon intra-aortique sur la mortalité et le taux de complications lors d’un pontage aorto-coronarien. Une revue systématique de la littérature avec meta-analyse a ainsi été entreprise dans ce contexte à l’Institut universitaire de cardiologie et de pneumologie de Québec. Bien qu’une réduction de la mortalité ait été observée avec le ballon intra-aortique au sein des études à répartition aléatoire, de tels résultats n’ont pu être obtenus des études à caractère rétrospectif. Qui plus est, nombreuses étaient les limitations relevées au sein des essais randomisés, mandatant interprétation prudente des effets observés. À la lumière de ces résultats controversés, nous ne pouvons encourager une utilisation préoperatoire du ballon intra-aortique aussi répandue qu’elle l’est actuellement. La continuelle investigation de ce champ d’expertise est impérative afin de caractériser les risques et bénéfices réels associés à cette pratique mandatant une interprétation prudente des effets observes. À la lumière de ces résultats controversés, nous ne pouvons encourager une utilisation préoperatoire du ballon intra-aortique aussi répandue qu’elle l’est actuellement. La continuelle investigation de ce champ d’expertise est impérative afin de caractériser les risques et bénéfices réels associés à cette pratique.
La maladie coronarienne athérosclérotique représente la première cause de mortalité à travers le monde. De nombreux traitements existent dans le but de réduire son incidence et sa symptomatologie. Parmi ceux-ci, la chirurgie de revascularisation par pontage aorto-coronarien demeure le plus efficace, mais les risques qui lui sont associés sont importants. Le ballon intra-aortique est un outil mécanique de support à la circulation utilise en cas d’instabilité hémodynamique, notamment en contexte de pontage aorto-coronarien. Il agit en augmentant la perfusion coronarienne en diastole et en réduisant la postcharge ventriculaire gauche en systole. Son utilisation est encadrée dans plusieurs situations, mais les évidences entourant sa pratique demeurent faibles et controversées. Ce mémoire avait donc comme objectif l’évaluation de l’impact de l’installation préoperatoire d’un ballon intra-aortique sur la mortalité et le taux de complications lors d’un pontage aorto-coronarien. Une revue systématique de la littérature avec meta-analyse a ainsi été entreprise dans ce contexte à l’Institut universitaire de cardiologie et de pneumologie de Québec. Bien qu’une réduction de la mortalité ait été observée avec le ballon intra-aortique au sein des études à répartition aléatoire, de tels résultats n’ont pu être obtenus des études à caractère rétrospectif. Qui plus est, nombreuses étaient les limitations relevées au sein des essais randomisés, mandatant interprétation prudente des effets observés. À la lumière de ces résultats controversés, nous ne pouvons encourager une utilisation préoperatoire du ballon intra-aortique aussi répandue qu’elle l’est actuellement. La continuelle investigation de ce champ d’expertise est impérative afin de caractériser les risques et bénéfices réels associés à cette pratique mandatant une interprétation prudente des effets observes. À la lumière de ces résultats controversés, nous ne pouvons encourager une utilisation préoperatoire du ballon intra-aortique aussi répandue qu’elle l’est actuellement. La continuelle investigation de ce champ d’expertise est impérative afin de caractériser les risques et bénéfices réels associés à cette pratique.
Coronary artery disease is the leading cause of mortality worldwide. Several different treatments currently exist in order to reduce its incidence and symptomatology. Revascularization by coronary artery bypass graft surgery (CABG) remains the most effective option, however the risks associated with this intervention are considerable. Intra1aortic balloon pump (IABP) is a mechanical cardiac assist1device primarily used for hemodynamically unstable patients undergoing coronary artery bypass grafting. The pump increases diastolic coronary artery blood flow and reduces systolic left ventricular afterload. Use of IABP has been described in various situations but the indications regarding its installation remain weak and controversial. The purpose of this master’s thesis was to assess the impact of preoperative installation of IABP on both mortality and complication rates in patients undergoing CABG. A systemic review of the literature and a meta1 analysis were therefore completed at the Institut universitaire de cardiologie et de pneumologie de Québec. While results showed a reduction in mortality with IABP in randomized controlled trials, such was not the case in retrospective studies. Moreover, many limitations reported in randomized controlled trials demanded careful interpretation in order to identify real observed effects. In light of the controversial results found, we cannot fully encourage the widespread use of preoperative intra1aortic balloon pump, as opposed to the current trend in the literature. In order to better characterize the associated risks regarding this practice, further investigation is required.
Coronary artery disease is the leading cause of mortality worldwide. Several different treatments currently exist in order to reduce its incidence and symptomatology. Revascularization by coronary artery bypass graft surgery (CABG) remains the most effective option, however the risks associated with this intervention are considerable. Intra1aortic balloon pump (IABP) is a mechanical cardiac assist1device primarily used for hemodynamically unstable patients undergoing coronary artery bypass grafting. The pump increases diastolic coronary artery blood flow and reduces systolic left ventricular afterload. Use of IABP has been described in various situations but the indications regarding its installation remain weak and controversial. The purpose of this master’s thesis was to assess the impact of preoperative installation of IABP on both mortality and complication rates in patients undergoing CABG. A systemic review of the literature and a meta1 analysis were therefore completed at the Institut universitaire de cardiologie et de pneumologie de Québec. While results showed a reduction in mortality with IABP in randomized controlled trials, such was not the case in retrospective studies. Moreover, many limitations reported in randomized controlled trials demanded careful interpretation in order to identify real observed effects. In light of the controversial results found, we cannot fully encourage the widespread use of preoperative intra1aortic balloon pump, as opposed to the current trend in the literature. In order to better characterize the associated risks regarding this practice, further investigation is required.
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ALBOUY, DOMINIQUE. "Evolution des indications de pontage aorto-coronaire : etude de deux populations (annees 1983-84 et annee 1989) ayant beneficie d'une revascularisation myocardique chirurgicale." Clermont-Ferrand 1, 1990. http://www.theses.fr/1990CLF13053.

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Khairy, Mostafa. "Pontage de VO-nHO et caractérisation." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37614676f.

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Bond, Helen Katharine. "Pontius Pilate in history and interpretation." Thesis, Durham University, 1994. http://etheses.dur.ac.uk/967/.

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Khairy, Mostafa. "Pontage de V2O5 nH2O et caractérisation." Orléans, 1988. http://www.theses.fr/1988ORLE2046.

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Vignes, Jean-Pierre. "Urétéro-hydronéphrose et pontage aorto-bifémoral." Bordeaux 2, 1991. http://www.theses.fr/1991BOR2M192.

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Bittner, Angela. "Gesellschaft und Wirtschaft in Herakleia Pontike : eine Polis zwischen Tyrannis und Selbstverwaltung /." Bonn : R. Habelt, 1998. http://catalogue.bnf.fr/ark:/12148/cb388943742.

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Texte remanié de: Diss.--Philosophischen Fakultät--Erlangen, Nürnberg--Friedrich-Alexander Universität, 1996.
La couv. porte en plus : "Forschungsstelle Asia Minor im Seminar für Alte Geschichte der Westfälischen Wilhelms-Universität Münster" Contient la transcription des livres 9 à 16 de la chronique d'Héraclée de Memnon, avec la traduction allemande en regard. Bibliogr. p. 214-225.
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Gueorguieva, Nevena Dimitrova. "Amphorae and amphora stamps from Apollonia Pontica." Thesis, Royal Holloway, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271537.

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EL-ACHI, ABDALLAH. "Le pontage des arteres interventriculaires anterieures occluses." Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX20710.

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Condrea, Corin-Nicolae. "Problèmes de psychologie chez Evagre le Pontique." Université Marc Bloch (Strasbourg) (1971-2008), 2001. http://www.theses.fr/2001STR20065.

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Le moine grec Evagre le Pontique a marqué l'histoire de la spiritualité chrétienne par sa doctrine ascétique, même si une partie de son oeuvre a été condamnée comme hérétique. Fruit de l'enseignement de ses maîtres égyptiens et de sa propre expérience ascétique, cette doctrine est remarquable par son caractère systématique et par les problèmes de psychologie qu'elle soulève. Pour arriver à discerner ces problèmes et à essayer d'en expliquer certains, nous avons présenté d'abord son anthropologie. Nous avons établi ensuite des distinctions dans la terminologie évagrienne en ce qui concerne les pensées, les passions, l'action des démons. Quant à la référence psychologique choisie, la terminologie de C. G. Jung nous a paru la plus appropriée pour notre recherche. Nous avons utilisé certains mécanismes psychologiques décrits par le psychologue suisse pour expliquer à l'homme moderne, une partie de la pensée du moine du IVe siècle. Cette étude veut défricher quelques pistes dans une direction bien établie : l'étude psychologique de la doctrine ascétique évagrienne. D'autres points de vue doivent être considérés pour enlever les ombres qui restent encore sur l'oeuvre du moine pontique
The Greek monk Evagrios Ponticos marked the history of Christian spirituality by his ascetic doctrine, even if part of his writings were condemned as heretics. These doctrine, result of the teaching of its Egyptian Masters and his own ascetic experiment, is remarkable by its systematic character and the problems of psychology which it raises. In order to distinguish these problems and to try to explain some of them, we presented initially his anthropology. .
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Dal, Forno Manuela. "A família Graphidaceae (Ascomycota Liquenizados) em restinga em Pontal do Sul, Pontal do Paraná, Paraná /." PDF version, 2009. http://dspace.c3sl.ufpr.br:8080/dspace/handle/1884/18156.

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Dal, forno Manuela. "A família Graphidaceae (Ascomycota Liquenizados) em restinga em Pontal do Sul, Pontal do Paraná, Paraná." reponame:Repositório Institucional da UFPR, 2009. http://hdl.handle.net/1884/18156.

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Papon, Xavier. "Les pontages femoro-poplites hauts en polytetrafluoroethylene : etude retrospective de 217 pontages ; resultats a long terme." Angers, 1994. http://www.theses.fr/1994ANGE1028.

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POULET, MARIE-LAURE. "Le pontage grande saphene in situ par tunnellisation trans-osseuse tibiale dans la revascularisation distale des arteres tibiale anterieure et peroniere : analyse retrospective d'une serie de 27 cas." Angers, 1991. http://www.theses.fr/1991ANGE1056.

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Le, Goanvic Christophe. "L'angor post-pontage : a propos de 248 patients." Toulouse 3, 1994. http://www.theses.fr/1994TOU31531.

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DELAIRE, DIDIER. "Pontage coronarien chez les sujets de plus de 70 ans : analyse de l'experience de 3 annees d'activite au c.h.r.u. de nice." Nice, 1991. http://www.theses.fr/1991NICE6002.

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NGUYEN, RODOLPHE. "Pontages aorto-bifemoraux pour lesions obliterantes aorto-iliaques : a propos de 150 cas." Toulouse 3, 1991. http://www.theses.fr/1991TOU31577.

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COURTHALIAC, ANNIE. "Traitement chirurgical des coarctations compliquees de l'aorte a l'age adulte par by-pass aorto-aortique : a propos de 8 cas operes entre 1977 et 1988." Lyon 1, 1990. http://www.theses.fr/1990LYO1M052.

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DAVERAT, ISABELLE. "Pontages axillo-bifemoraux : indications, technique, resultats : a propos de 15 cas originaux." Bordeaux 2, 1988. http://www.theses.fr/1988BOR25051.

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SAHAFI, FEREYDOUN. "Pontage coronaire au-dela de 70 ans; resultats a court et long terme : a propos de 73 cas." Lille 2, 1990. http://www.theses.fr/1990LIL2M030.

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Coelho, Mario Cesar. "Moderna ponte velha :." Florianópolis, SC, 1997. http://repositorio.ufsc.br/xmlui/handle/123456789/77241.

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Costa, Sandro da Silveira. "Ponte Hercílio Luz." Florianópolis, SC, 2002. http://repositorio.ufsc.br/xmlui/handle/123456789/82560.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-Graduação em História.
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A presente pesquisa tem como tema principal as mutações urbanas no centro da cidade de Florianópolis promovidas pela construção da ponte Hercílio Luz. O que se propõe é discutir a maneira como a ponte Hercílio Luz desencadeou mudanças no meio urbano de Florianópolis, uma vez que a cidade desde sua fundação no século XVII, até as primeiras décadas do século XX, não dispunha de uma ligação terrestre entre o espaço insular e continental. Objetiva-se, desta forma, discutir quais as transformações mais imediatas na área insular da cidade de Florianópolis. Ou seja, pretende-se estudar quais as vias próximas à ponte que se converteram nos principais meios de escoamento do tráfego rumo ao centro da cidade. Paralelamente, busca-se entender como delineou-se, de forma predominante, o sentido de orientação do desenvolvimento urbano. Objetiva-se, igualmente, referenciar essas mutações na parte continental da cidade (Estreito e arredores), analisando a dinâmica populacional e comercial entre a Ilha e o Continente.
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Hayashi, Fernando Augusto Yudyro. "Ponte Hercílio Luz." reponame:Repositório Institucional da UFSC, 2012. http://repositorio.ufsc.br/handle/123456789/103429.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Arquitetura e Urbanismo, Florianópolis, 2012.
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Este trabalho busca identificar os principais aspectos relacionados com o projeto de uma ponte pênsil desenvolvido por Robinson & Steinman em 1923 para a sua execução em Florianópolis, ligando a ilha de Santa Catarina com o continente. São apresentadas considerações sobre a logística utilizada e algumas das estratégias adotadas nas etapas de construção da ponte. Busca-se também caracterizar as intervenções da ponte ao longo de nove décadas, onde são mostradas as diferentes configurações e tipos de utilização com as decorrentes transformações da paisagem no entorno. Este trabalho ainda apresenta um breve diagnóstico das principais manifestações patológicas observadas e um resumo das manutenções realizadas de modo a apresentar um quadro sintético do atual estado de conservação da ponte. Por fim, são apresentados os aspectos mais relevantes das propostas de restauração e reabilitação, cujas obras estão em fase de execução.

Abstract : This research seeks to identify the main aspects of the project of a suspension bridge designed by Robinson & Steinman in 1923 constructed in Florianópolis, connecting the island of Santa Catarina to the mainland. Logistics and some of the strategies adopted in the stages of construction of the bridge are presented. The interventions on the bridge over nine decades are described in this investigation, which shows the different settings and types of use with the resulting changes in the surrounding landscape. This study also presents a brief diagnosis of the main pathological manifestations observed and a summary of maintenance performed in order to present the current condition of the bridge. Finally, the most relevant aspects of the proposed rehabilitation and restoration are presented, whose works are in progress.
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Bailly, Rémy. "Application de la dynamique moléculaire à plusieurs échelles au complexe hélicase : pontine/reptine." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0415/document.

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Pontine et Reptine constituent de nouvelles cibles thérapeutiques encore très méconnues à ce jour. Outre leur activité ATPase, les complexes multimériques de Pontine et Reptine ont été décrits comme des hélicases capables d’ouvrir les acides nucléiques. La modélisation moléculaire constitue un outil puissant pour l’étude des systèmes protéiques et c’est pourquoi une approche par docking et dynamique a été envisagée. Au vue de la taille d’un complexe à douze sous-unités, les simulations prenant en compte tous les atomes se sont avérées trop coûteuses en termes de puissance de calcul. Une approche mésoscopique,appelée gros-grains, a donc été utilisée pour réduire le nombre de particules à traiter. Legain de temps de calcul offert par ce modèle nous a permis d’étudier les complexes de Pontine et Reptine en présence de partenaires de type ligands, l’ATP et l’ADP, et de type acide nucléique. Par le biais d’un retour au niveau atomique, une ouverture de la double hélice d’ADN a pu être observée ainsi qu’une orientation préférentielle des brins. Des hypothèses mécanistiques de l'activité hélicase du complexe ont alors pu être formulées sur la base de ces résultats
Pontin/Reptin complexes offer new therapeutic opportunities despite the fact they are still notwell known. In addition to their ATPase activity, multimeric complexes of Pontin/Reptin were reported as hélicases able to unwind nucleic acids. Molecular modeling techniques are a powerful tool to study proteins, both a docking and molecular dynamics were applied.Considering the size of a twelve sub-units complex, simulations taking into account all atoms were too expensive in terms of computational costs. A mesoscopic approach, called coarse grain,was used to reduce the number of particles. The calculation time saved with this model allowed the study of Pontin/Reptin complexes in the presence of diverse partners like small ligands (ATP or ADP) and/or nucleic acids. Reverse transformation from coarse-grain to the atomic level led to a DNA double helix opening along to the single strands rearrangement.Several mechanistic hypotheses for the complex helicase activity were formulated from these results
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Tsahourides, Matthaios. "The Pontic Lyra in Contemporary Greece." Thesis, Goldsmiths College (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506971.

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This thesis examines the performance techniques for playing the Politic l>>ra, a vertically-held bottle-shaped bowed lute which is the main instrument of the Poetic Greeks. The objectives of the research were to identify the ways in which the traditional performance techniques for the lyra have been extended in the past, especially in the work of Gogos Petrides, and to explore the possibilities of extending these further in order to enable the lyra player to effectively perform styles and repertoires from outside Greece, with particular reference to the music of Afghanistan. A detailed discussion of changes in performance practices required the use of a broad range of contextualising material, enabling the author to position his work in the context of modern Greece. The thesis begins with a historical overview and provides background information about the culture and history of the Pontic settlements on the Black Sea coast of what is modern Turkey, up to the population exchanges of 1922. It provides a detailed organological study of the instrument and looks into its history, concluding it has a European/Byzantine rather than a Middle Eastern origin. The author also discusses the traditional and the contemporary performance techniques of the Pontic lyra and describes his own experience as both performer and ethnographer during extended periods of fieldwork. The DVD and CD included in the thesis are of major importance as they provide a key role in demonstrating and illustrating the author's core research methods, findings and outcomes. The author's work was `mirrored' in an unassessed recital given at the end of the research. Chapter 1 provides a historical overview of the culture of the Pontic Greeks. Chapter 2 describes the morphology of the Pontic lyra and discusses its origins. Chapter 3 discusses the traditional and the contemporary performance techniques for the lyra; the author also describes his own learning experience within the context of a musical family. Chapter 4 considers three traditional genres of lyra music, the extended techniques attributed to Gogos Petrides, which have been further developed by the author. Chapter 5 recounts fieldwork carried out in Greece with six well-established Pontic musicians, who have much to say about the influence of Gogos Petrides. Chapter 6 explains how, through making a study of Afghan music as played on the dutar and rubab, the author has adapted pre-existing and devised new techniques for playing the Afghan repertoire on the Pontic lyra. Chapter 7 summarises the research carried out, while an Appendix describes the preparations made for the recital which is part of the examination process. This thesis is accompanied by a CD and a DVD illustrating aspects of the research.
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Gruppuso, Paolo. "From marshes to reclamation : there and back again : contested nature, memories and practices in two wetlands of Agro Pontino, Italy." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230972.

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What is a wetland? What does this category imply? Is it different from a land which is wet? This thesis addresses these questions through a study of environmental conflicts in two protected wetlands in Agro Pontino, Italy. This region, 70 kilometres south of Rome, was affected between the 1920s and the 1930s, by one of the most important operations of land reclamation of that time, conducted by the fascist regime which drained the largest marshland in Italy, i.e. the Pontine Marshes. Based on fieldwork in protected wetlands considered as the remnants of the Pontine Marshes, the thesis includes the analysis of various original case studies, such as the activities of Environmental Interpretation and farming, among others. Moreover, it discloses archive records that cast new light on the social and environmental context of the Pontine Marshes. The thesis explores how farmers and conservationists relate with a particular kind of environment, namely wetlands in conservation areas; their relations with non-humans; their different reading of the history and evolution of these landscapes and the connections between these aspects and the conflicts affecting these areas. These conflicts concern different ideas of what a wetland should be and the appropriate practices aimed at implementing those ideas. The research, which is influenced by the work of Tim Ingold, challenges the established notion of wetland, based on a topographic and spatial understanding of the world, suggesting that wetlands are patterns characterized by movements, tasks and activities: entanglements of innumerable life-lines traced by human and non-human beings in the accomplishment of their tasks. It is in this entanglement which politics emerge, conflicts flourish and life goes on. Accordingly, I argue that following these life-lines and exploring what I call the geography of the meshwork, can disclose new interpretative perspectives to understand environmental conflicts.
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Sökmen, Emine. ""Temple states" of Pontus Comana Pontica and Zela /." [Ankara] : METU, 2005. http://os.osdd.net/index.php/record/view/87033.

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Fremiot, Karine Rozec Jean. "Evaluation de l'intérêt du dosage du NT-proBNP (Elecsys) en chirurgie cardiaque." [S.l.] : [s.n.], 2004. http://theses.univ-nantes.fr/thesemed/SPEfremiot.pdf.

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NAVARRO, XAVIER. "Thromboses precoces et tardives de protheses aorto-bifemorales : a propos de 114 sujets." Clermont-Ferrand 1, 1992. http://www.theses.fr/1992CLF13816.

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MILLION-RANQUIN, MARTIAL. "Pontages composites sous le genou : resultats a propos de 83 cas." Lyon 1, 1989. http://www.theses.fr/1989LYO1M209.

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GOURDIER, ANNE-LAURENCE. "Fibrinolyse in situ des pontages arteriels des membres inferieurs : resultats initiaux et tardifs : a propos de 62 procedures." Angers, 1992. http://www.theses.fr/1992ANGE1028.

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TINELLI, RICHARD. "Pontage ou angioplastie chez les patients pluritronculaires : etude prospective ; resultats immediats et a court terme." Toulouse 3, 1991. http://www.theses.fr/1991TOU31004.

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PADOVANI, MICHEL. "Les pontages jambiers pour arteriopathie chronique obliterante des membres inferieurs : a propos de 73 cas." Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX20172.

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Iqbal, Mustafa. "Pintas jantung paru pada bedah jantung menyebabkan gangguan metabolisme laktat di hati : infus natrium laktat hipertonik memperbaiki hemodinamik dan status asam basa." Université Joseph Fourier (Grenoble), 2002. http://www.theses.fr/2002GRE10240.

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