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Journal articles on the topic 'Population analysis profile (PAP)'

Author: Grafiati

Published: 11 December 2022

Last updated: 31 July 2025

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1

Casapao, Anthony M., Susan L. Davis, John Paul McRoberts, et al. "Evaluation of Vancomycin Population Susceptibility Analysis Profile as a Predictor of Outcomes for Patients with Infective Endocarditis Due to Methicillin-Resistant Staphylococcus aureus." Antimicrobial Agents and Chemotherapy 58, no. 8 (2014): 4636–41. http://dx.doi.org/10.1128/aac.02820-13.

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ABSTRACTInfective endocarditis due to methicillin-resistantStaphylococcus aureus(MRSA IE) is associated with high morbidity and mortality. Vancomycin continues to be the primary treatment for this disease. The emergence of heterogeneous vancomycin-intermediateStaphylococcus aureus(hVISA), defined as a modified population analysis profile (PAP) of ≥0.9, may affect patient outcomes. The objective of this study was to evaluate the relationship of vancomycin subpopulation susceptibility and the clinical outcomes of MRSA IE. We conducted a retrospective cohort study of patients treated with vancomy

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Binda, Elisa, Francesca Berini, Flavia Marinelli, Adriana Bava, and Fabrizio Beltrametti. "Heterogeneous A40926 Self-Resistance Profile in Nonomuraea gerenzanensis Population Informs Strain Improvement." Fermentation 7, no. 3 (2021): 140. http://dx.doi.org/10.3390/fermentation7030140.

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Nonomuraea gerenzanensis ATCC 39727 produces the glycopeptide antibiotic A40926, which is the natural precursor of the semi-synthetic, last-resort drug dalbavancin. To reduce the cost of dalbavancin production, it is mandatory to improve the productivity of the producing strain. Here, we report that the exposure of N. gerenzanensis wild-type population to sub-inhibitory concentrations of A40926 led to the isolation of differently resistant phenotypes to which a diverse A40926 productivity was associated. The most resistant population (G, grand colonies) represented at least the 20% of the colo

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Bathavatchalam, Yamuna Devi, Dhanalakshmi Solaimalai, Anushree Amladi, Hariharan Triplicane Dwarakanathan, Shalini Anandan, and Balaji Veeraraghavan. "Vancomycin heteroresistance in Staphylococcus haemolyticus: elusive phenotype." Future Science OA 7, no. 7 (2021): FSO710. http://dx.doi.org/10.2144/fsoa-2020-0179.

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Aim: To determine the presence of vancomycin heteroresistance in Staphylococcus haemolyticus. Materials & methods: A total of 48 rifampicin-resistant S. haemolyticus isolates from bloodstream infections were included. Vancomycin heteroresistance was determined using the population analysis profile-area under curve (PAP-AUC) method. All the isolates were screened for the presence of mecA gene, mutations in the rpoB gene, staphylococcal cassette chromosome mec and multilocus sequence types. Results: Fifteen isolates were identified as heteroresistant vancomycin-intermediate S. haemolyticus u

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Wootton, M. "A modified population analysis profile (PAP) method to detect hetero-resistance to vancomycin in Staphylococcus aureus in a UK hospital." Journal of Antimicrobial Chemotherapy 47, no. 4 (2001): 399–403. http://dx.doi.org/10.1093/jac/47.4.399.

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Wootton, M. "A modified population analysis profile (PAP) method to detect hetero-resistance to vancomycin in Staphylococcus aureus in a UK hospital." Journal of Antimicrobial Chemotherapy 48, no. 1 (2001): 161. http://dx.doi.org/10.1093/jac/48.1.161.

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Hermes, Djuli M., Caroline Pormann Pitt, Larissa Lutz, et al. "Evaluation of heteroresistance to polymyxin B among carbapenem-susceptible and -resistant Pseudomonas aeruginosa." Journal of Medical Microbiology 62, no. 8 (2013): 1184–89. http://dx.doi.org/10.1099/jmm.0.059220-0.

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One hundred and twenty-four Pseudomonas aeruginosa isolates were selected for antimicrobial susceptibility testing with anti-pseudomonal agents, MIC determination for polymyxin B and metallo-beta-lactamase detection (genes bla SPM, bla VIM-1, bla NDM-1 and bla IMP). According to the imipenem and/or meropenem susceptibility profile, a set of randomly selected isolates (12 isolates carbapenem-susceptible and 12 isolates carbapenem-resistant) were evaluated for heteroresistance to polymyxin B. Heteroresistance testing was performed by plating the isolates onto increasing concentrations of polymyx

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Khatib, Riad, Kathleen Riederer, Mamta Sharma, Stephen Shemes, Sugantha P. Iyer, and Susan Szpunar. "Screening for Intermediately Vancomycin-Susceptible and Vancomycin-Heteroresistant Staphylococcus aureus by Use of Vancomycin-Supplemented Brain Heart Infusion Agar Biplates: Defining Growth Interpretation Criteria Based on Gold Standard Confirmation." Journal of Clinical Microbiology 53, no. 11 (2015): 3543–46. http://dx.doi.org/10.1128/jcm.01620-15.

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BHI agars supplemented with vancomycin 4 (BHI-V4) and 3 (BHI-V3) mg/liter have been proposed for screening vancomycin intermediately susceptibleStaphylococcus aureus(VISA) and heteroresistant (hVISA) phenotypes, respectively, but growth interpretation criteria have not been established. We reviewed the growth results (CFU) during population analysis profile-area under the curve (PAP-AUC) of consecutive methicillin-resistantStaphylococcus aureus(MRSA) blood isolates, which were saved intermittently between 1996 and 2012. CFU counts on BHI-V4 and BHI-V3 plates were stratified according to PAP-AU

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Baaity, Zain, Friederike D. von Loewenich, Elisabeth Nagy, et al. "Phenotypic and Molecular Characterization of Carbapenem-Heteroresistant Bacteroides fragilis Strains." Antibiotics 11, no. 5 (2022): 590. http://dx.doi.org/10.3390/antibiotics11050590.

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Carbapenem-resistant Bacteroides fragilis strains usually emerge by an insertion sequence (IS) jump into the upstream region of the cfiA carbapenemase gene. However, intermediate or fully resistant cfiA-positive strains also exist. These do not have such IS element activations, but usually have heterogeneous resistance (HR) phenotypes, as detected by a disc diffusion or gradient tests. Heteroresistance is a serious antibiotic resistance problem, whose molecular mechanisms are not fully understood. We aim to characterize HR and investigate diagnostic issues in the set of cfiA-positive B. fragil

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Khalili, Kianoush. "0565 The Obstructive Sleep Apnea CPAP Therapy Compliance; Progressions, Challenges and Interventions." SLEEP 46, Supplement_1 (2023): A248—A249. http://dx.doi.org/10.1093/sleep/zsad077.0565.

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Abstract Introduction Obstructive sleep apnea (OSA) is a common sleep disorder affecting 26% of the United States adult population and is associated with adverse health outcomes. Despite the advent of an array of treatment options, PAP remains the primary treatment modality for OSA since the approach was introduced in 1981. The objective of this systematic review is to determine how we can increase compliance to PAP therapy as the gold standard of OSA treatment. Methods A systematic review was conducted to study meta-analyses performed to determine the clinical significance of using PAP in sev

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10

Sun, Wenjia, Hongbin Chen, Yudong Liu, et al. "Prevalence and Characterization of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Isolates from 14 Cities in China." Antimicrobial Agents and Chemotherapy 53, no. 9 (2009): 3642–49. http://dx.doi.org/10.1128/aac.00206-09.

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ABSTRACT The prevalence of heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) among 1,012 vancomycin-susceptible methicillin (meticillin)-resistant S. aureus isolates collected from 14 cities in China from 2005 to 2007 was 13 to 16%, as determined by a combination of (i) measurement by the modified population analysis profile-area under the curve method (PAP-AUC) and (ii) estimation from the measured sensitivity and specificity of a screening method. Two hundred isolates from blood were chosen as a subset for measurement of the sensitivities and the specificities of several pr

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Howard-Anderson, Jessica, Michelle Davis, Alexander M. Page, et al. "Prevalence of colistin heteroresistance in carbapenem-resistant Pseudomonas aeruginosa and association with clinical outcomes in patients: an observational study." Journal of Antimicrobial Chemotherapy 77, no. 3 (2021): 793–98. http://dx.doi.org/10.1093/jac/dkab461.

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Abstract Objectives To describe the prevalence of colistin heteroresistance in carbapenem-resistant Pseudomonas aeruginosa (CRPA) and evaluate the association with clinical outcomes. Methods Colistin heteroresistance was evaluated in CRPA isolates collected from patients without cystic fibrosis in Atlanta, Georgia, USA using two definitions: HR1, growth at 4 and 8 mg/L of colistin at a frequency ≥1 × 10−6 the main population; and HR2, growth at a colistin concentration ≥8× the MIC of the main population at a frequency ≥1 × 10−7. A modified population analysis profile (mPAP) technique was compa

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Pongkumpai, Montri, Suwanna Trakulsomboon, and Chusana Suankratay. "An evaluation of 2.0 McFarland Etest method for detection of heterogeneous vancomycin-intermediate Staphylococcus aureus." Asian Biomedicine 4, no. 1 (2010): 141–45. http://dx.doi.org/10.2478/abm-2010-0016.

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Abstract Background: Staphylococcus aureus with reduced susceptibility to vancomycin or heterogeneous vancomycinintermediate S. aureus (hVISA) have become increasingly reported from various parts of the world. hVISA cannot be detected by routine test for minimal inhibitory concentration (MIC) for vancomycin. The gold standard method for detection, population analysis profiles (PAP) method, is complicated, time-consuming, expensive, and needs well-trained microbiologists. Objective: Evaluate of 2.0 McFarland Etest method, in comparison with the PAP method, for detection of hVISA in clinical spe

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Silveira, A. C. O., J. Caierão, C. I. Silva, et al. "Impact of mutations in hVISA isolates on decreased susceptibility to vancomycin, through population analyses profile – area under curve (PAP-AUC)." Diagnostic Microbiology and Infectious Disease 95, no. 3 (2019): 114854. http://dx.doi.org/10.1016/j.diagmicrobio.2019.06.006.

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Telles O Lima, Jurema, Carla Rameri Alexandre Silva De Azevedo, Candice Lima Lima, et al. "Concrete case: An opportunity to improve cervical cancer prevention—Primary and secondary prevention of cervical cancer in patients with cervical cancer and their families." Journal of Clinical Oncology 39, no. 15_suppl (2021): e18571-e18571. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e18571.

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e18571 Background: cervical cancer (CC) reveals regional and social inequalities and should be understood not only as an oncological indicator, but essentially as an indicator of social vulnerability and health care needs.CC is the second most incident and the most deadly among women from the Northeast’S Brazil and the third most incident in Brazil Although the HPV vaccine coverage and the Pap smear test are available through the Brazilian public health system, the coverage of the target population is low. objective: Verify the conditions of access/use of the health system by women with cervic

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Shinde, Shraddha, Xiaoyu Lin, Can Yin, Meghan Pettine, Atif Adam, and Swarna Khare. "0536 Patient Profiles and Treatment Patterns for Obstructive Sleep Apnea (OSA) in Germany: A Real-world Data Analysis." SLEEP 47, Supplement_1 (2024): A229—A230. http://dx.doi.org/10.1093/sleep/zsae067.0536.

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Abstract Introduction Obstructive sleep apnea (OSA) impacts approximately 30% of 30–69-year-olds in Germany, however comprehensive real-world data on patient demographics, diagnostic pathway, and treatment patterns, remains limited. This study aims to analyze real-world data to characterize OSA patient profiles and their treatment journey within Germany. Methods Retrospective longitudinal analysis of German Statutory Health Insurance claims data, including 146,227 adults (≥18 years) diagnosed with OSA between 2012-2022. Data included patient demographics, clinical diagnoses, sleep study histor

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Horne, K. C., B. P. Howden, E. A. Grabsch, et al. "Prospective Comparison of the Clinical Impacts of Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus (MRSA) and Vancomycin-Susceptible MRSA." Antimicrobial Agents and Chemotherapy 53, no. 8 (2009): 3447–52. http://dx.doi.org/10.1128/aac.01365-08.

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ABSTRACT Although methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) strains with reduced susceptibility to vancomycin (RVS-MRSA; including vancomycin-intermediate S. aureus [VISA] and heterogeneous VISA [hVISA]) have been linked with vancomycin treatment failure, it is unclear whether they are more pathogenic than vancomycin-susceptible MRSA (VS-MRSA). We prospectively assessed patients with clinical MRSA isolates during a 10-month period to determine clinical status (infection versus colonization) and therapeutic outcome before correlating these findings with the results of deta

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Handayani, Ririn. "Long term Depot Medroxy Progesterone Asetate (DMPA) Injectable Increase Changes in Lipid Profiles of DMPA Injection Contraceptive Acceptors." Jurnal Kesehatan dr. Soebandi 9, no. 1 (2021): 46–51. http://dx.doi.org/10.36858/jkds.v9i1.257.

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DMPA injectable contraceptives can cause changes in lipoprotein metabolism. Long term use of DMPA increases triglyceride levels, total cholesterol and LDL and decreases HDL levels. So, it can be concluded that DMPA can cause changes in lipid metabolism which can increase the risk of cardiovascular disease. Changes in fat metabolism occur due to the influence of the hormonal progesterone, which causes disruption of the balance of the lipid profile in the body. The purpose of this study was to determine the effect of using Depo Medroxy Progeserone Acetate injection on the lipid profile of three

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Morales-León, Felipe, Celia A. Lima, Gerardo González-Rocha, Andrés Opazo-Capurro та Helia Bello-Toledo. "Colistin Heteroresistance among Extended Spectrum β-lactamases-Producing Klebsiella pneumoniae". Microorganisms 8, № 9 (2020): 1279. http://dx.doi.org/10.3390/microorganisms8091279.

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Colistin-heteroresistant (CST-HR) Enterobacterales isolates have been identified recently, challenging the clinical laboratories since routine susceptibility tests fail to detect this phenotype. In this work we describe the first CST-HR phenotype in extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae isolates in South America. Additionally, we determine the genomic mechanisms of colistin heteroresistance in these strains. The CST-HR phenotype was analyzed by the population analysis profile (PAP) method, and mutations associated with this phenotype were determined by whole-geno

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Wongthong, Sujintana, Karnjana Dutchanutouch, Viladda Namsaengkang, Aroonwadee Chanawong, Chotechana Wilailuckana, and Aroonlug Lulitanond. "Performance of vancomycin and teicoplanin disk diffusion test in isogenic vancomycin non-susceptible Staphylococcus aureus." Journal of Infection in Developing Countries 9, no. 02 (2015): 157–64. http://dx.doi.org/10.3855/jidc.5059.

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Introduction: Detection of heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) is currently problematic. Although the population analysis profile with area under the curve (PAP-AUC) is the gold standard for detecting hVISA strains, this method is time consuming. This study aimed to induce vancomycin non-susceptible Staphylococcus aureus isolates in methicillin-resistant S. aureus (MRSA) and to determine the performance of the vancomycin and teicoplanin disk diffusion test for screening of induced and natural vancomycin non-susceptible isolates. Methodology: Vancomycin resistanc

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Chacko, Kieran, Colleen Beckford, Carlotta Calvi Molina, and Harm Van Bakel. "2561. Using Whole Genome Sequencing to Assess the Emergence of Antibiotic Resistance During Treatment of Enterococcus faecium and Enterococcus faecalis Bacteremia at Mount Sinai Hospital." Open Forum Infectious Diseases 5, suppl_1 (2018): S71. http://dx.doi.org/10.1093/ofid/ofy209.169.

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Abstract Background Multidrug-resistant Enterococci are a major cause of nosocomial infections, yet our understanding of how resistance emerges during antibiotic treatment remains incomplete. We performed whole- and complete-genome sequencing of all paired isolates from 11 Enterococcus faecium and 10 Enterococcus faecalis cases that acquired resistance during hospitalization at Mount Sinai Hospital. Comparative and phylogenetic genomic analyses identified novel mechanisms of resistance and heteroresistance. Methods 2.5 years of electronic health records were analyzed to identify cases of bacte

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Shen, Ping, Kai Zhou, Yu Wang, et al. "High prevalence of a globally disseminated hypervirulent clone, Staphylococcus aureus CC121, with reduced vancomycin susceptibility in community settings in China." Journal of Antimicrobial Chemotherapy 74, no. 9 (2019): 2537–43. http://dx.doi.org/10.1093/jac/dkz232.

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Abstract Objectives Most vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA) are derived from hospital-associated MRSA due to treatment failure; however, the prevalence of hVISA/VISA in community settings remains unclear. Methods Four hundred and seventy-six community-associated isolates were collected between 2010 and 2011 during national surveillance for antimicrobial resistance in 31 county hospitals across China. Drug susceptibility evaluation and mecA detection were performed by using broth microdilution and PCR analysis, respectively. hVISA/VISA were ident

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MacGowan, Alasdair P., Chris A. Rogers, H. Alan Holt, and Karen E. Bowker. "Activities of Moxifloxacin against, and Emergence of Resistance in, Streptococcus pneumoniae and Pseudomonas aeruginosa in an In Vitro Pharmacokinetic Model." Antimicrobial Agents and Chemotherapy 47, no. 3 (2003): 1088–95. http://dx.doi.org/10.1128/aac.47.3.1088-1095.2003.

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ABSTRACT The pharmacodynamics of moxifloxacin against Streptococcus pneumoniae and Pseudomonas aeruginosa were investigated in a pharmacokinetic infection model. Three strains of S. pneumoniae, moxifloxacin, and two strains of P. aeruginosa were used. Antibacterial effect and emergence of resistance were measured for both species over a 72-h period using an initial inoculum of about 108 CFU/ml. At equivalent area under the curve (AUC)/MIC ratios, S. pneumoniae was cleared from the model while P. aeruginosa was not. For S. pneumoniae, the area under the bacterial kill curve up to 72 h could be

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Farias, Taiza Rôse De Oliveira, Rosangela Diniz Cavalcante, Romanniny Hévillyn Silva Costa, Richardson Augusto Rosendo Da Silva, Camyla Bernardo Medeiros, and Marcela Fernandes De Araújo Batista De Morais. "Profile of women between 45 and 49 years who have never had the PAP Test." Revista de Enfermagem UFPE on line 6, no. 2 (2012): 401. http://dx.doi.org/10.5205/reuol.2052-14823-1-le.0602201220.

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ABSTRACTObjective: to present the profile of women who never underwent oncotic cytology, living in Paraiso neighborhood, in the town of Santa Cruz, Rio Grande do Norte, Brazil. Method: this is an investigation with a quantitative design, carried out with 12 women from 45 to 49 years, after the approval by the Research Ethics Committee of Universidade do Estado do Rio Grande do Norte (UERN) (Protocol 002/10). The data collection was held from May to August 2010, with the application of structured and semi-structured questionnaires, with information regarding age, education, profession/occupatio

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Rodriguez, Carlos A., Maria Agudelo, Andres F. Zuluaga, and Omar Vesga. "Generic Vancomycin Enriches Resistant Subpopulations of Staphylococcus aureus after Exposure in a Neutropenic Mouse Thigh Infection Model." Antimicrobial Agents and Chemotherapy 56, no. 1 (2011): 243–47. http://dx.doi.org/10.1128/aac.05129-11.

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ABSTRACTPrevious studies have shown that “bioequivalent” generic products of vancomycin are less effectivein vivoagainstStaphylococcus aureusthan the innovator compound. Considering that suboptimal bactericidal effect has been associated with emergence of resistance, we aimed to assessin vivothe impact of exposure to innovator and generic products of vancomycin onS. aureussusceptibility. A clinical methicillin-resistantS. aureus(MRSA) strain from a liver transplant patient with persistent bacteremia was used for which MIC, minimum bactericidal concentration (MBC), and autolytic properties were

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Gratsianskaya, S. E., and T. V. Martynyuk. "COMPARATIVE CLINICAL CHARACTERISTICS OF PATIENTS WITH VARIOUS FORMS OF PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONGENITAL HEART DISEASE, ACCORDING TO THE CLINICAL CLASSIFICATION." Eurasian heart journal, no. 4 (December 30, 2019): 108–21. http://dx.doi.org/10.38109/2225-1685-2019-4-108-121.

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Objective: to conduct a comprehensive analysis of the clinical, functional, hemodynamic profile of patients with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) according to the Russian Registry.Materials and methods: The study involved 30 patients with Eisenmenger syndrome, 25 patients with PAH associated with prevalent systemic-to-pulmonary shunts and 26 patients with PAH after defect correction. All patients had been entered in the Russian registry (NCT03707561). A comparative analysis of clinical, functional, hemodynamic parameters was held. The diagnosis

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Nouer, Simone, Débora S. Fernandes, Rennan Les, Adriana Lucia Pires Ferreira, and Kátia Regina Netto dos Santos. "Bloodstream Infections Caused by S. aureus: Daptomycin Nonsusceptibility and Clinical Aspects." Infection Control & Hospital Epidemiology 41, S1 (2020): s143. http://dx.doi.org/10.1017/ice.2020.658.

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Background:Staphylococcus aureus is one of the leading pathogens isolated from bloodstream infections (BSIs), and vancomycin has been the main choice to treat MRSA (methicillin-resistant S. aureus) infections. Vancomycin-intermediate S. aureus (VISA) and heteroresistant-VISA (hVISA) have been described, limiting this antibiotic use. We evaluated aspects associated with the resistance and its clonality of the S. aureus isolated from BSIs, and we determined their association with clinical aspects of patients attended at Rio de Janeiro between 2016 and 2018. The detection of MRSA and trimethoprim

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Hagihara, Mao, Seth T. Housman, David P. Nicolau, and Joseph L. Kuti. "In VitroPharmacodynamics of Polymyxin B and Tigecycline Alone and in Combination against Carbapenem-Resistant Acinetobacter baumannii." Antimicrobial Agents and Chemotherapy 58, no. 2 (2013): 874–79. http://dx.doi.org/10.1128/aac.01624-13.

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ABSTRACTCarbapenem-resistantAcinetobacter baumanniiis increasing in prevalence. Polymyxin B and tigecycline are among the most active antibiotics used against this pathogenin vitro. Pastin vitrostudies, however, neglected the importance of simulating exposures observed in humans to determine their antibacterial effects. In this study, four carbapenem-resistantA. baumanniiisolates were evaluated using anin vitropharmacodynamic model. Free-drug exposures using 1 mg/kg of body weight of polymyxin B every 12 h (q12h), 100 and 200 mg tigecycline q12h, and the combination of these regimens were simu

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Castro, Betsy E., Maritza Berrio, Monica L. Vargas, et al. "Detection of heterogeneous vancomycin intermediate resistance in MRSA isolates from Latin America." Journal of Antimicrobial Chemotherapy 75, no. 9 (2020): 2424–31. http://dx.doi.org/10.1093/jac/dkaa221.

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Abstract Background Vancomycin is a common first-line option for MRSA infections. The heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) phenotype is associated with therapeutic failure. However, hVISA isolates are usually reported as vancomycin susceptible by routine susceptibility testing procedures. Objectives To detect and characterize the hVISA phenotype in MRSA isolates causing infections in nine Latin American countries. Methods We evaluated a total of 1189 vancomycin-susceptible MRSA isolates recovered during 2006–08 and 2011–14. After an initial screening of hVISA usi

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Vieira, Rodrigo Covre, Jaqueline de Sá Lima Heninng, Camila Carla da Silva Costa, et al. "Câncer de colo uterino: detecção precoce e ações educativas com mulheres universitárias." Revista Ciência em Extensão 13, no. 1 (2017): 72–82. https://doi.org/10.23901/1679-4605.2017v13n1p72-82.

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Background: Cervical cancer (CC) is the most common cancer among women from northern Brazil. The periodic performance of Pap testing enables the identification of precursor lesions of cancer and provides high rates of recovery. Objectives: To promote educational measures and early detection of CC among university students, using the Pap test, the polymerase chain reaction (PCR) test for human papillomavirus (HPV), and advice about the risk factors associated with viral infections. Methods: This study is part of a university extension program focused on health care for adolescents and young pub

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Klisic, Aleksandra, Nebojsa Kavaric, Sanja Vujcic, Vesna Spasojevic-Kalimanovska, Jelena Kotur-Stevuljevic, and Ana Ninic. "Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population." Oxidative Medicine and Cellular Longevity 2021 (January 27, 2021): 1–9. http://dx.doi.org/10.1155/2021/6661940.

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Different byproducts of oxidative stress do not always lead to the same conclusion regarding its relationship with cardiometabolic risk, since controversial results are reported so far. The aim of the current study was to examine prooxidant determinant ((prooxidant-antioxidant balance (PAB)) and the marker of antioxidant defence capacity (total sulphydryl groups (tSHG)), as well as their ratio (PAB/tSHG) in relation to different cardiometabolic risk factors in the cohort of adult population. Additionally, we aimed to examine the joint effect of various cardiometabolic parameters on these marke

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Pratama, Adam Kurnia, and Khoiril Anam. "Variasi indeks massa tubuh pemain PS POP Bhayangkara Muda Semarang 2022 berdasarkan posisi bermain." Sepakbola 3, no. 1 (2023): 8. https://doi.org/10.33292/sepakbola.v3i1.201.

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Sepakbola merupakan olahraga yang dimainkan oleh dua tim, dimana masing-masing tim terdiri 11 pemain inti. Permainan ini hampir eluruhnya menggunakan anggota tubuh kecuali tangan, kecuali penjaga gawang yang boleh menggunakan tangan di areanya. Untuk menunjang performa dalam permainan sepakbola, seorang pemain perlu memiliki Indeks Massa Tubuh yang ideal. Â . Penelitian ini bertujuan menganalisis Indeks Massa Tubuh pemain PS POP Bhayangkara Muda Semarang Penelitian menggunakan model survey dengan tes dan pengukuran untuk mengetahui profil indeks massa tubuh pemain sepakbola PS POP Bhayangkara

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Halliday, Jane L., Evelyne Muggli, Sharon Lewis, et al. "Alcohol consumption in a general antenatal population and child neurodevelopment at 2 years." Journal of Epidemiology and Community Health 71, no. 10 (2017): 990–98. http://dx.doi.org/10.1136/jech-2017-209165.

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BackgroundPrenatal alcohol exposure (PAE) is a community health problem with up to 50% of pregnant women drinking alcohol. The relationship between low or sporadic binge PAE and adverse child outcomes is not clear. This study examines the association between PAE in the general antenatal population and child neurodevelopment at 2 years, accounting for relevant contributing factors.MethodsThis prospective population-based cohort recruited 1570 pregnant women, providing sociodemographic, psychological and lifestyle information and alcohol use for five time periods. PAE categories were ‘low’, ‘mod

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Xu, Jia, Long Pang, Xiao Xue Ma, et al. "Phenotypic and molecular characterisation of Staphylococcus aureus with reduced vancomycin susceptibility derivated in vitro." Open Medicine 13, no. 1 (2018): 475–86. http://dx.doi.org/10.1515/med-2018-0071.

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AbstractVancomycin has been the primary agent used to treat serious Methicillin-resistantStaphylococcus aureus(MRSA) infection for many years. However, the rise of MRSA infection rates and the extensive use of vancomycin have led to the emergence of reduced vancomycin susceptibility. Therefore, four typicalStaphylococcus aureus(S. aureus)strains from different clinical specimens were derivated by vancomycin in vitro to better clarify their phenotypic and molecular characteristics. Some experiments, such as stepwise selection of vancomycin-resistant strains, pulsed-field gel electrophoresis (PF

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Choby, Jacob E., Tugba Ozturk, Sarah W. Satola, Jesse T. Jacob, and David Weiss. "LB16. Surveillance Rates of Cefiderocol Heteroresistance Correlate With All-cause Mortality in the APEKS-NP and CREDIBLE-CR Trials." Open Forum Infectious Diseases 8, Supplement_1 (2021): S813. http://dx.doi.org/10.1093/ofid/ofab466.1652.

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Abstract Background Cefiderocol is a recently FDA approved, novel siderophore beta-lactam antibiotic. Conventional antimicrobial susceptibility testing (AST) suggests that a variety of Gram-negative pathogens, including carbapenem-resistant (CR) isolates, are overwhelmingly susceptible to cefiderocol.. This antibiotic performed well in the APEKS-NP trial for the treatment of nosocomial pneumonia caused largely by carbapenem susceptible isolates. However, in the CREDIBLE-CR trial involving exclusively CR Gram-negative bacteria, cefiderocol was associated with a higher rate of all-cause mortalit

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Thompson, J. P., J. G. Sheedy, and N. A. Robinson. "Resistance of Wheat Genotypes to Root-Lesion Nematode (Pratylenchus thornei) Can be Used to Predict Final Nematode Population Densities, Crop Greenness, and Grain Yield in the Field." Phytopathology® 110, no. 2 (2020): 505–16. http://dx.doi.org/10.1094/phyto-06-19-0203-r.

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The root-lesion nematode Pratylenchus thornei is a major pathogen of wheat (Triticum aestivum) in many regions globally. Resistance of wheat genotypes to P. thornei can be determined from final nematode population densities in glasshouse experiments but combining results across multiple experiments presents challenges. Here, we use a factor analytic method for multiexperiment analysis of final population densities of P. thornei for 1,096 unique wheat genotypes in 22 glasshouse experiments. The resistance to P. thornei of the genotypes was effectively represented by a two-factor model with rota

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Wieteska-Miłek, Maria, Sebastian Szmit, Michał Florczyk, Beata Kuśmierczyk-Droszcz, Robert Ryczek, and Marcin Kurzyna. "COVID-19 Vaccination in Patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: Safety Profile and Reasons for Opting against Vaccination." Vaccines 9, no. 12 (2021): 1395. http://dx.doi.org/10.3390/vaccines9121395.

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The incidence of COVID-19 infection in patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) is similar to that in the general population, but the mortality rate is much higher. COVID-19 vaccination is strongly recommended for PAH/CTEPH patients. The aim of our cross-sectional study was to identify reasons why PAH/CTEPH patients refused vaccination against COVID-19. Moreover, we assessed the safety profile of approved COVID-19 vaccines in PAH/CTEPH patients. We examined 261 patients (164 PAH patients and 97CTEPH patients) with a median ag

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Duan, Jianchun, Longgang Cui, Guoqiang Wang, et al. "Immunotherapy efficacy and safety of programmed cell death 1 (PD-1) versus programmed death ligand-1 (PD-L1) inhibitors in pan-cancer: A systematic review and meta-analysis." Journal of Clinical Oncology 37, no. 15_suppl (2019): e14113-e14113. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e14113.

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e14113 Background: Immune checkpoint inhibitors (ICIs) that target programmed cell death 1 (PD-1) and its ligand (PD-L1) have led to a paradigm shift in cancer treatment, while whether PD-1 and PD-L1 inhibitors deliver different clinical outcomes remains obscure. Here we carried out a systematic review and meta-analysis to compare the efficacy and safety profile of PD-1 and PD-L1 inhibitors in pan-cancer patients. Methods: We systematically searched PubMed, Cochrane library, and Embase from January 2000 to December 2018 for randomized controlled trials that compared PD-1/PD-L1 inhibitors with

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Seol, Hee Yun, Mary C. Rolfes, Wi Chung, et al. "Expert artificial intelligence-based natural language processing characterises childhood asthma." BMJ Open Respiratory Research 7, no. 1 (2020): e000524. http://dx.doi.org/10.1136/bmjresp-2019-000524.

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IntroductionThe lack of effective, consistent, reproducible and efficient asthma ascertainment methods results in inconsistent asthma cohorts and study results for clinical trials or other studies. We aimed to assess whether application of expert artificial intelligence (AI)-based natural language processing (NLP) algorithms for two existing asthma criteria to electronic health records of a paediatric population systematically identifies childhood asthma and its subgroups with distinctive characteristics.MethodsUsing the 1997–2007 Olmsted County Birth Cohort, we applied validated NLP algorithm

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Nurmayuli, Nurmayuli, and Raujatul Jannah. "Rancang Bangun Kokurikuler Penerapan P5PPRA di MI Kota Lhokseumawe." An-Nidzam : Jurnal Manajemen Pendidikan dan Studi Islam 11, no. 2 (2024): 171–85. https://doi.org/10.33507/an-nidzam.v11i2.2273.

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Changes in the independent curriculum make school principals and teachers must be ready to follow these changes. Where in the independent curriculum there are 2 parts, namely instraural learning and project-based learning to strengthen the character of the Pancasila student profile. However, in the statement of the implementation of the Pancasila Student Profile Strengthening Project and the Rahmatan lil Alamin Student Profile (P5PPRA) in each Madrasah, there are still obstacles in determining the project theme. The purpose of the research is to design and build the P5PPRA co-curricular in MI

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Jotte, Robert M., Federico Cappuzzo, Ihor Vynnychenko, et al. "IMpower131: Primary PFS and safety analysis of a randomized phase III study of atezolizumab + carboplatin + paclitaxel or nab-paclitaxel vs carboplatin + nab-paclitaxel as 1L therapy in advanced squamous NSCLC." Journal of Clinical Oncology 36, no. 18_suppl (2018): LBA9000. http://dx.doi.org/10.1200/jco.2018.36.18_suppl.lba9000.

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LBA9000 Background: Atezolizumab (atezo; anti–PD-L1) demonstrated OS benefit vs docetaxel in 2L+ NSCLC regardless of PD-L1 status or tumor histology. Because cytotoxic agents can exhibit positive immunomodulatory effects, combining atezo with chemotherapy may further improve outcomes. IMpower131 (NCT02367794) was designed to evaluate atezo + carboplatin (carbo) + paclitaxel (pac) or nab-paclitaxel (nab-pac) in 1L stage IV squamous NSCLC. Methods: Patients (pts) were randomized 1:1:1 to Arm A (atezo 1200 mg q3w + carbo AUC 6 q3w + pac 200 mg/m2 q3w), Arm B (atezo + carbo + nab-pac 100 mg/m2 wee

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Wu, Hongjiang, Eric S. H. Lau, Aimin Yang, et al. "Age-specific population attributable risk factors for all-cause and cause-specific mortality in type 2 diabetes: An analysis of a 6-year prospective cohort study of over 360,000 people in Hong Kong." PLOS Medicine 20, no. 1 (2023): e1004173. http://dx.doi.org/10.1371/journal.pmed.1004173.

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Background The prevalence of type 2 diabetes has increased in both young and old people. We examined age-specific associations and population attributable fractions (PAFs) of risk factors for all-cause and cause-specific mortality in people with type 2 diabetes. Methods and findings We analysed data from 360,202 Chinese with type 2 diabetes who participated in a territory-wide diabetes complication screening programme in Hong Kong between January 2000 and December 2019. We compared the hazard ratios and PAFs of eight risk factors, including three major comorbidities (cardiovascular disease [CV

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Shitara, Kohei, Ben George, Julien Taieb, et al. "The impact of prior therapies on outcomes with trifluridine/tipiracil (FTD/TPI) in the phase III TAGS trial." Journal of Clinical Oncology 39, no. 3_suppl (2021): 247. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.247.

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247 Background: It is unclear whether prior treatment with ramucirumab (RAM) or RAM plus paclitaxel (PAC), standard second-line treatments for metastatic gastric or gastroesophageal junction cancer (mGC/GEJC), can influence outcomes with third-line chemotherapy in this patient (pt) population (pop). In the phase 3 TAGS trial, FTD/TPI showed a survival benefit vs placebo (PBO) in pts with mGC/GEJC who had received ≥2 prior chemotherapy regimens. Post hoc analyses were performed to assess the impact of prior RAM, PAC or RAM+PAC treatment on the efficacy and safety of FTD/TPI in TAGS. Methods: Pt

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Silbermins, Damian, Laura M. De Castro, Jude C. Jonassaint, Shiaowen David Hsu, Marilyn J. Telen, and Jen-Tsan Chi. "Genomic Approaches to Identifying Risk for Pulmonary Artery Hypertension among Individuals with Sickle Cell Disease." Blood 112, no. 11 (2008): 1442. http://dx.doi.org/10.1182/blood.v112.11.1442.1442.

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Abstract Pulmonary artery hypertension (PAH) occurs in 30–50% of adult patients with sickle cell disease (SCD), with mortality ranging from 16 to 50% and a median survival of 25 months. Our objective was to use gene expression profiling to develop a gene signature predictor for PAH through the analysis of gene expression of blood cells from SCD patients with or without PAH. We hypothesized that these gene signatures could allow us to identify patients at risk for PAH, as well as to generate hypotheses as to the pathophysiology of PAH in SCD. We used Affymetrix U133A2 GeneChip to determine the

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Hoke, Frank, Kara Schmelzer, Jianping Zhang, Philip Lorenzi, and Iman El-Hariry. "Population Pharmacokinetics of Eryaspase in Patients with Acute Lymphoblastic Leukemia or Pancreatic Adenocarcinoma." Blood 136, Supplement 1 (2020): 1–2. http://dx.doi.org/10.1182/blood-2020-134377.

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L-asparaginase (ASNase) is a microbial enzyme and a chemotherapeutic agent that has been a standard component of multi-agent chemotherapy for the treatment of acute lymphoblastic leukemia (ALL). Eryaspase, ASNase encapsulated in red blood cells, is being developed with an improved pharmacokinetic profile compared to some other ASNase products. The purpose of the present analysis was to describe the population pharmacokinetics (Pop PK) of eryaspase and sources of variability in two patient populations - ALL or pancreatic adenocarcinoma (PAC). Eryaspase was administered intravenously at doses of

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Ramos-Flores, Christian, Teresa Romero-Gutiérrez, Iván Delgado-Enciso, et al. "Polymorphisms in the Genes Related to Angiogenesis Are Associated With Uterine Cervical Cancer." International Journal of Gynecologic Cancer 23, no. 7 (2013): 1198–204. http://dx.doi.org/10.1097/igc.0b013e31829f4c6f.

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IntroductionThe expression of plasminogen activator inhibitor type 1 (PAI-1), vascular endothelial growth factor (VEGF), and transforming growth factor β1 (TGF-β1) participates in the angiogenesis of several cancer types. The goal of this study was to investigate polymorphisms in genes related to angiogenesis (PAI-1-675 4G/5G, VEGF C936T, and TGF-β1 G-800A) to evaluate the risk for developing uterine cervical cancer (UCC).MethodsIn a case-control study, 100 healthy subjects and 100 patients with UCC from Mexico were included. We determined the genetic profile of the polymorphic markers, which

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Kurysheva, Natalia I., Oxana Y. Rodionova, Alexey L. Pomerantsev, Galina A. Sharova, and Olga Golubnitschaja. "Machine learning–couched treatment algorithms tailored to individualized profile of patients with primary anterior chamber angle closure predisposed to the glaucomatous optic neuropathy." EPMA Journal 14, no. 3 (2023): 527–38. http://dx.doi.org/10.1007/s13167-023-00337-1.

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Abstract Background Primary angle closure glaucoma (PACG) is still one of the leading causes of irreversible blindness, with a trend towards an increase in the number of patients to 32.04 million by 2040, an increase of 58.4% compared with 2013. Health risk assessment based on multi-level diagnostics and machine learning–couched treatment algorithms tailored to individualized profile of patients with primary anterior chamber angle closure are considered essential tools to reverse the trend and protect vulnerable subpopulations against health-to-disease progression. Aim To develop a methodology

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Sanders, James, Marguerite Monogue, David E. Greenberg, Christine A. Pybus, and Andrew E. Clark. "1222. Ceftolozane-Tazobactam Heteroresistance in Cystic Fibrosis Related Pseudomonas aeruginosa Infections." Open Forum Infectious Diseases 8, Supplement_1 (2021): S701. http://dx.doi.org/10.1093/ofid/ofab466.1414.

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Abstract Background Cystic fibrosis (CF) patients are often colonized with Pseudomonas aeruginosa (PSA). During treatment, PSA can develop subpopulations exhibiting variable in vitro antimicrobial susceptibility patterns. Heteroresistance may underlie the reported discordant in vitro results and clinical responses to various antimicrobials. Here, we sought to examine the presence and nature of PSA heteroresistance to ceftolozane-tazobactam (C-T) in isolates originating from CF pulmonary exacerbations. Methods Respiratory cultures from 26 adult CF patients were collected. From each sample, 5-10

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Borah, Meghna, and Rohini Goswami. "Sociodemographic and clinical characteristics of a diabetic population at a tertiary care center in Assam, India." Journal of Social Health and Diabetes 05, no. 01 (2017): 037–42. http://dx.doi.org/10.4103/2321-0656.193997.

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Abstract Aims: To elucidate the sociodemographic and clinical characteristics of patients with type 2 diabetes mellitus (T2DM) attending a tertiary care hospital in Dibrugarh, Assam. Subjects and Methods: A total of 132 T2DM patients (74 males and 48 females) were included in the study. Patients were evaluated with detailed history, meticulous examination, and laboratory investigations and given a detailed interview questionnaire to fill out. Statistical Analysis Used: Graph Pad Prism, published by GraphPad Software, Inc., California. Results: The highest prevalence was found in the age group

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Pálešová, Nina, Léa Maitre, Stratakis Nikos, et al. "Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study)." International Journal of Hygiene and Environmental Health 252 (July 5, 2023): 114215. https://doi.org/10.1016/j.ijheh.2023.114215.

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<strong>Introduction</strong>: Firefighting is one of the most hazardous occupations due to exposure to per- and polyfluoroalkyl substances (PFAS) and polycyclic aromatic hydrocarbons (PAHs). Such exposure is suspected to affect the cardiometabolic profile, e.g., liver function and serum lipids. However, only a few studies have investigated the impact of this specific exposure among firefighters. <strong>Methods: </strong>Men included in the CELSPAC-FIREexpo study were professional firefighters (n = 52), newly recruited firefighters in training (n = 58), and controls (n = 54). They comple

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Kilari, Deepak, Chintan Pandya, Chunkit Fung, et al. "Characteristics and outcomes of elderly patients with systemic prostate cancer (PCa) treated with peripheral androgen blockade (PAB)." Journal of Clinical Oncology 31, no. 6_suppl (2013): 226. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.226.

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226 Background: The side effect profile of androgen deprivation (ADT) warrants exploration of alternative options for elderly patients with systemic PCa. In phase 2 trials, the combination of anti-androgen and 5 alpha reductase inhibitor (PAB) demonstrated efficacy with low morbidity in the fit population. The objective of this retrospective study was to evaluate the characteristics and outcomes of elderly patients treated with PAB in lieu of ADT. Methods: We reviewed records of patients ≥65 yrs who received PAB in the geriatric oncology program from 2007-2012. Patients were evaluated with a v

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