Log in

Relevant bibliographies by topics / Poröse Medien / Journal articles

To see the other types of publications on this topic, follow the link: Poröse Medien.

Journal articles on the topic 'Poröse Medien'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 47 journal articles for your research on the topic 'Poröse Medien.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Stoltenberg, D., D. Enke, and A. Seidel-Morgenstern. "Mesoporöse Glasmembranen als Modellsysteme zur Untersuchung der Gasdiffusion durch poröse Medien." Chemie Ingenieur Technik 82, no. 6 (April 30, 2010): 829–35. http://dx.doi.org/10.1002/cite.201000021.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Brink, Norbert, Thomas Wehler, and Udo Werner. "Die Durchströmung von Schüttungen mit kompressiblen Medien bei überlagerter Injektion bzw. Absaugung von Masse durch poröse Wände." Chemie Ingenieur Technik 63, no. 10 (October 1991): 1022–23. http://dx.doi.org/10.1002/cite.330631015.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Weiss, W. "Numerische Simulation von porösen Medien." ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik 80, S1 (2000): 169–72. http://dx.doi.org/10.1002/zamm.20000801343.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Maennel, Hartmut. "Perkolationstheorie: Stochastische Modelle poröser Medien." Mathematische Semesterberichte 41, no. 2 (September 1994): 179–206. http://dx.doi.org/10.1007/bf03186509.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Neumann, T., C. Bergins, and K. Strauß. "Mehrphasige Durchströmung kompressibler und heterogener poröser Medien." Chemie Ingenieur Technik 78, no. 6 (June 2006): 701–8. http://dx.doi.org/10.1002/cite.200500167.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Huwe, Bernd. "Water Movement in Porous Media with Time-dependent Porosity." Zeitschrift der Deutschen Geologischen Gesellschaft 136, no. 2 (December 1, 1985): 311–19. http://dx.doi.org/10.1127/zdgg/136/1985/311.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Hashemzadeh, Abdulmajid, and Werner-Michael Kulicke. "Degradation von Polymer-Molekülen beim Durchströmen poröser Medien." Chemie Ingenieur Technik 58, no. 4 (1986): 325–27. http://dx.doi.org/10.1002/cite.330580412.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Keil, Frerich J. "Modellierung von heterogen-katalysierten Reaktionen in porösen Medien." Chemie Ingenieur Technik 83, no. 12 (November 11, 2011): 2188–210. http://dx.doi.org/10.1002/cite.201100158.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Mack, S., M. A. Hussein, and T. Becker. "Numerische Modellierung der Wärme- und Stoffübertragung in porösen Medien." Chemie Ingenieur Technik 82, no. 9 (August 27, 2010): 1367. http://dx.doi.org/10.1002/cite.201050507.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Hohenthanner, C. R., W. Kast, and H. Fröhlich. "Stationäre und instationäre Permeations- und Diffusionsmessungen in porösen Medien." Chemie Ingenieur Technik 70, no. 12 (December 1998): 1549–53. http://dx.doi.org/10.1002/cite.330701211.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Keil, F. J. "Modellierung von Adsorption, Diffusion und katalysierten Reaktionen in porösen Medien." Chemie Ingenieur Technik 82, no. 6 (May 6, 2010): 881–90. http://dx.doi.org/10.1002/cite.201000016.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Mahler, Frank, and Diethard Hesse. "Probleme bei der Computersimulation des diffusiven Stofftransports inrekonstruierten porösen Medien." Chemie Ingenieur Technik 72, no. 10 (October 2000): 1195–99. http://dx.doi.org/10.1002/1522-2640(200010)72:10<1195::aid-cite1195>3.0.co;2-s.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Menzel, Olaf, and Diethard Hesse. "Probleme bei der Computersimulation des Random-Walk in rekonstruierten porösen Medien." Chemie Ingenieur Technik 72, no. 12 (December 2000): 1545–49. http://dx.doi.org/10.1002/1522-2640(200012)72:12<1545::aid-cite1545>3.0.co;2-a.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

ERMILOV, SERGEY G., and JOSEF STARÝ. "New taxa of oribatid mites from Korup National Park (Cameroon). The genus Pergalumna (Acari, Oribatida, Galumnidae), with description of three new species and a key to known species from the Ethiopian region." Zootaxa 4425, no. 2 (May 30, 2018): 201. http://dx.doi.org/10.11646/zootaxa.4425.2.1.

Full text

Abstract:

Three new species of oribatid mites of the genus Pergalumna (Oribatida, Galumnidae) are described from litter and soil in the Korup National Park (Cameroon). Pergalumna jenoi sp. nov. differs from P. margaritata Mahunka, 1989 and P. pseudomargaritata Mahunka, 1994 by the presence of simple dorsosejugal suture, dentate anterior margin of the ventral plate, distinct reticulate pattern on the pteromorphs and dense stria on the genital plates, the localization of setal alveoli la posterior to porose areas Aa, and the absence of a median pore. Pergalumna tuberclesejugalis sp. nov. differs from P. margaritata and P. pseudomargaritata by the larger body size, the localization of porose areas Aa closer to lm than la, and setal alveoli h3 close and lateral to A2, the presence of sejugal porose areas, and the absence of a median pore and stria on the genital plates. Pergalumna grebennikovi sp. nov. differs from P. bifissurata Hammer, 1972 by the larger body size, the presence of smooth bothridial setae, well-developed interlamellar setae, reticulate anterior margin of pteromorphs, comparatively long prodorsal median ridge and a median pore, and the localization of setal alveoli la and porose areas Aa. An identification key to the known species of the genus Pergalumna from the Ethiopian region is presented.

APA, Harvard, Vancouver, ISO, and other styles

15

Zheng, Qian-Fen, Wen-Qin Liang, Guo-Ru Ren, and Mao-Fa Yang. "Two new and a newly recorded species of the genus Pergalumna (Acari, Oribatida, Galumnidae) from China." Acarologia 61, no. 1 (March 12, 2021): 154–72. http://dx.doi.org/10.24349/acarologia/20214424.

Full text

Abstract:

Two new species, Pergalumna clava n. sp. and Pergalumna pilosus n. sp., and a newly recorded species, Pergalumna amamiensis Aoki, 1984 of oribatid mites are described and illustrated from China. Pergalumna clava n. sp. is different from most known species of Pergalumna in the dorsosejugal suture complete; developed four pairs notogastral porose areas, Aa transverse irregular wedge; short interlamellar seta and bothridial seta clavate. Pergalumna pilosus n.sp. different from most known species of Pergalumna in the dorsosejugal suture complete; Aa porose area transverse irregular wedge; longer interlamellar barbed; median pore and postanal porose area present.

APA, Harvard, Vancouver, ISO, and other styles

16

Ma, Y., and G. Brenner. "Hybride Parallelisierung von Lattice-Boltzmann-Verfahren zur Berechnung von Transportvorgängen in porösen Medien." Chemie Ingenieur Technik 85, no. 9 (August 23, 2013): 1381–82. http://dx.doi.org/10.1002/cite.201250710.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Bockhorn, H., and I. Dinkov. "Direkte numerische Simulation auf Porenskala der Strömung und Verbrennung in porösen inerten Medien." Chemie Ingenieur Technik 86, no. 9 (August 28, 2014): 1594. http://dx.doi.org/10.1002/cite.201450304.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Akrami, Mohammad Ali, Fatemeh Ordouni, and Sara Ramroodi. "A new species of Pergalumna (Acari: Oribatida: Galumnidae) from southeastern Iran, including a key to all species of the genus from the Palaearctic region." Systematic and Applied Acarology 26, no. 2 (January 25, 2021): 379–94. http://dx.doi.org/10.11158/saa.26.2.5.

Full text

Abstract:

A new species of oribatid mite of the family Galumnidae, Pergalumna sistanbaluchestanica sp. nov., is described and illustrated based on adult specimens from soil in Sistan and Baluchestan province, southeastern Iran. The new species is characterized by dentate rostrum; long interlamellar setae; long, setiform, finely barbed bothridial setae; complete dorsosejugal furrow; large, nearly triangular porose areas Aa; presence of median pore in females and males; large, elongated postanal porose area and large body size. The new species is most similar morphologically to P. seminervosa Mahunka & Mahunka-Papp, 2008, however, differs from it in morphology of bothridial setae and notogastral porose areas Aa and also by the surface ornamentation of the pteromorphs and genital plates; localization of setal alveoli la and lyrifissures im and body size. An identification key to known species of Pergalumna from the Palaearctic region is given.

APA, Harvard, Vancouver, ISO, and other styles

19

Liang, Wenqin, Maofa Yang, and Guoru Ren. "Two new species of the genus Galumna (Acari: Oribatida: Galumnidae) from China." Systematic and Applied Acarology 23, no. 4 (March 26, 2018): 603. http://dx.doi.org/10.11158/saa.23.4.3.

Full text

Abstract:

Two new species of Galumna Heyden, 1826, Galumna (Galumna) wuzhishanensis sp. nov. and Galumna (Galumna) longisensilla sp. nov., are described from soil and leaf litter samples in Hainan and Guizhou Provinces, China. Adults of Galumna (Galumna) wuzhishanensis sp. nov., is morphologically most similar to Galumna (Galumna) acutirostrum Ermilov, 2010, however it differs from the latter by the body length and pattern of surface, length of interlamellar setae, location of im and the absence of median pore and postanal porose area. Adults of Galumna (Galumna) longisensilla sp. nov., is morphologically most similar to Galumna (Galumna) calva Starý, 1997, but differs by the shape of Aa and location of gla, size of A3 and the presence of postanal porose area.

APA, Harvard, Vancouver, ISO, and other styles

20

HAGINO, WATARU, and SATOSHI SHIMANO. "Supplementary descriptions of Pergalumna amamiensis Aoki, 1984 (Acariformes, Galumnoidea) from Ryukyu Islands." Zootaxa 4647, no. 1 (July 26, 2019): 378–84. http://dx.doi.org/10.11646/zootaxa.4647.1.24.

Full text

Abstract:

A species of oribatid mites, Pergalumna amamiensis was collected from Amami-Ohshima Island, Ishigaki Island, and Okinawa Island, Southwestern Japan. The specimens were studied in detail, and supplementary descriptions are provided; these include features of the rostrum, the subcapitulum and the surface pattern of pteromorphs. The main morphological traits for this species are summarized as follows; body length 519–570 μm, body width 363–410 μm, rostral tip pointed, sensillus with a long stalk covered by minute barbs, porose areas Aa bulbous, porose areas A1, A2, and A3 circular, surface of pteromorphs ornamented by fine granular structure and dense wrinkles, fine granular structure on prodorsum, subcapitulum, genital plates and anal plates, median pore on the notogaster represented as single pore.

APA, Harvard, Vancouver, ISO, and other styles

21

ERMILOV, SERGEY G., ELIZABETH A. HUGO-COETZEE, and ALEXANDER A. KHAUSTOV. "Three new species of oribatid mites of the family Galumnidae (Acari, Oribatida) from South Africa." Zootaxa 4920, no. 1 (January 27, 2021): 91–100. http://dx.doi.org/10.11646/zootaxa.4920.1.3.

Full text

Abstract:

Three new species of oribatid mites of the family Galumnidae are described from soil and coniferous litter of Hogsback State Forest, Eastern Cape Province, South Africa. Pilogalumna hogsbackensis sp. nov. differs from Pilogalumna tenuiclava and P. ornatula by the presence of elongate oval postanal porose area and narrowly unilaterally dilated bothridial head. Pergalumna amatholensis sp. nov. differs from Pergalumna distincta by the presence of smaller body size, rounded rostrum, unilaterally dilated bothridial head, one pair of notogastral porose areas Aa, and the localization of opisthonotal gland opening and lyrifissure im. Stictozetes ihaguensis sp. nov. differs from all species of the genus by presence of bothridial seta with narrowly dilated head and median pore in both genders. An identification key to known species of Stictozetes is presented.

APA, Harvard, Vancouver, ISO, and other styles

22

Gálvez, J. C., E. B. Bermejo, A. Moragues, and M. Fernández Cánovas. "Permeabilidad y estructura porosa de hormigones autocompactantes de resistencia moderada." Materiales de Construcción 60, no. 299 (August 10, 2010): 37–51. http://dx.doi.org/10.3989/mc.2010.50709.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Ermilov, Sergey G., and Josef STARÝ. "Two new species of the genus Pergalumna (Acari, Oribatida, Galumnidae) from Northern Vietnam." Systematic and Applied Acarology 22, no. 4 (April 3, 2017): 494. http://dx.doi.org/10.11158/saa.22.4.6.

Full text

Abstract:

Two new species of oribatid mites of the genus Pergalumna (Oribatida, Galumnidae) are described from the Tam Dao National Park of Northern Vietnam. Pergalumna kunsti sp. nov. differs from P. magnipora xishuangbanna Aoki & Hu, 1993 by the larger body size, barbed bothridial setae, peanut-shell shaped notogastral porose areas Aa, lamellar setae longer than interlamellar setae and smooth genital plates. Pergalumna storkani sp. nov. differs from P. paratsurusakii Ermilov, Shtanchaeva, Kaluz & Subias, 2013 by the larger body size, rounded rostrum, strong and erect adanal setae ad2, lamellar setae longer than interlamellar setae, and the absence of a median pore.

APA, Harvard, Vancouver, ISO, and other styles

24

ERMILOV, SERGEY G., and JOSEF STARÝ. "New Galumnoidea (Acari, Oribatida) from Hanoi (Northern Vietnam)." Zootaxa 4379, no. 4 (February 15, 2018): 497. http://dx.doi.org/10.11646/zootaxa.4379.4.3.

Full text

Abstract:

Three new species of oribatid mites of the superfamily Galumnoidea (Acari, Oribatida) are described from vicinities of the city of Hanoi in Northern Vietnam. Allogalumna bochkovi sp. nov. differs from all species of the genus Allogalumna by the spindle-shaped bothridial setae having very long, setiform apex. Trichogalumna mironovi sp. nov. differs from all species of the genus Trichogalumna by the presence of a large quadrangular protruding rostrum and strong ridges of different form in median part of notogaster and anogenital region, and the absence of notogastral porose areas Aa. Galumnella paracellularis sp. nov. differs from G. cellularis Balogh & Mahunka, 1967 by the larger body size and reticulate prodorsum.

APA, Harvard, Vancouver, ISO, and other styles

25

Grunewald, J. "Mass and Energy Transport in Porous Media -Thermodynamical Identification of Driving Potentials/ Massen- und Energietransport in porösen Medien - thermodynamische Beschreibung der treibenden Potentiale." Restoration of Buildings and Monuments 5, no. 2 (April 1, 1999): 113–42. http://dx.doi.org/10.1515/rbm-1999-5354.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Ermilov, Sergey G., and Josef Starý. "Two new species of Galumna (Acari, Oribatida) from Andasibe-Mantadia National Park, Madagascar." Systematic and Applied Acarology 25, no. 8 (August 8, 2020): 1384–94. http://dx.doi.org/10.11158/saa.25.8.3.

Full text

Abstract:

Two new species of the subgenus Galumna (Galumna) (Oribatida, Galumnidae) are described from leaf litter of evergreen rain forest in eastern Madagascar. Galumna brevilineata sp. nov. differs from its closest species Galumna (Galumna) anuakensis Ermilov, 2019 and Galumna paracalcicola Ermilov & Anichkin 2014 by the length of interlamellar and lamellar setae, the localization of notogastral lyrifissures im, the ornamentation of anogenital region, the morphology of bothridial setae and postanal porose area, and the absence of median pore. Galumna (Galumna) paraarmatifera sp. nov. differs from its closest species Galumna armatifera Mahunka, 1996 by the morphology of bothridial setae and anal plates, and the length of circumpedal carinae. An identification key to species of Galumna (Galumna) of the calcicola-group (species with short lamellar lines) was presented.

APA, Harvard, Vancouver, ISO, and other styles

27

Ermilov, Sergey G., and Josef Starý. "New and interesting species of the genera Galumna and Pergalumna (Acari, Oribatida, Galumnidae) from the Montagne d'Ambre National Park, Madagascar." Acarologia 60, no. 1 (January 17, 2020): 64–74. http://dx.doi.org/10.24349/acarologia/20204357.

Full text

Abstract:

This work includes taxonomic and faunistic data on galumnid mites (Oribatida, Galumnidae) belonging to the genera Galumna and Pergalumna collected from the Montagne d'Ambre National Park, North Madagascar. Two new species are described: Galumna sandormahunkai n. sp. differs from its closest species, Galumna sphagni by the larger body size, the presence of strongly protruding rostrum, lanceolate, pointed apically bothridial setae, the direction of lamellar lines, and the absence of median pore; Pergalumna janosbaloghi n. sp. differs from the most similar species, Pergalumna aegra, by the smaller body size and the presence of long lamellar setae and elongate, distinctly or slightly triangular porose areas Aa. Galumna granalata and Pergalumna amamiensis are recorded in the Ethiopian region for the first time; Pergalumna conspicua and P. frater are recorded in Madagascar for the first time.

APA, Harvard, Vancouver, ISO, and other styles

28

Golubev, V. I. "Pore space colmatation during the bimodal suspension flow through the porous medium." Computational Mathematics and Information Technologies 3, no. 2 (2019): 67–75. http://dx.doi.org/10.23947/2587-8999-2019-2-2-67-75.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Scheufele, B. T. "Die Konstruktion von Feindbildern. Zum Sprachgebrauch in neonazistischen Medien [Constructing enemies. Speech acts in 'Neo-Nazi' media], Bernhard Porksen, Opladen, Westdeutscher Verlag, 2000, 232 pp., ISBN 3-531-13502-3." International Journal of Public Opinion Research 14, no. 4 (December 1, 2002): 478–80. http://dx.doi.org/10.1093/ijpor/14.4.478.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Ermilov, Sergey, Tapas Chatterjee, Mrinal Das, and Sabitry Bordoloi. "Three new species of oribatid mites of the genus Pergalumna (Acari: Oribatida: Galumnidae) from India." Biologia 69, no. 4 (January 1, 2014). http://dx.doi.org/10.2478/s11756-014-0332-5.

Full text

Abstract:

AbstractThree new oribatid mite species of the genus Pergalumna (Galumnidae) are described from growing mosses on rocks near a water stream in India. Pergalumna paraclericata sp. n. is very similar morphologically to Carinogalumna clericata (Berlese, 1914), however, it differs from the latter by the structure of lamellar lines and number of notogastral porose areas. Pergalumna minipora sp. n. is very similar morphologically to Pergalumna bifissurata Hammer, 1972, however, it differs from the latter by the body size and the presence of prodorsal ridges and a median pore. Pergalumna paracattienica sp. n. is very similar morphologically to Pergalumna cattienica Ermilov & Anichkin, 2011, however, it differs from the latter by the number of notogastral porose areas and the body integument on the ventral plate.

APA, Harvard, Vancouver, ISO, and other styles

31

Hagenau, Jens, and Heinz Borg. "Eine mathematische Beschreibung der Stoffauswaschung aus porösen Medien in Abhängigkeit von der applizierten Wassermenge und der Applikationsrate." altlasten spektrum, no. 2 (April 7, 2008). http://dx.doi.org/10.37307/j.1864-8371.2008.02.05.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Ermilov, Sergey G., and Josef Stary. "A new species of Pergalumna (Acari, Oribatida, Galumnidae) from Bolivia, with updated identification key to known species of the genus from the Neotropical region." Systematic and Applied Acarology, June 14, 2021, 1097–108. http://dx.doi.org/10.11158/saa.26.6.7.

Full text

Abstract:

A new species of Pergalumna (Oribatida, Galumnidae) is described from leaf litter of rain forest in the Espejillos environs near the Bolivian Ambor National Park. Pergalumna espejillosensis sp. nov. is similar to Pergalumna nasica Pérez-Íñigo & Baggio, 1980 in the presence of protruding rostrum, three pairs of rounded/oval notogastral porose areas and minute interlamellar seta, and in the absence of dorsosejugal suture, but differs by the smaller body length, setiform bothridial seta and long lamellar seta, and the absence of a median pore. An identification key to known species/subspecies of the genus from the Neotropical region is presented.

APA, Harvard, Vancouver, ISO, and other styles

33

Jereb, Sara, Natalija Planinc Strunjaš, and Matjaž Jereb. "Vpliv vrste povzročitelja na porast koncentracije prokalcitonina pri bolnikih s sepso." Slovenian Medical Journal 84, no. 2 (April 7, 2015). http://dx.doi.org/10.6016/zdravvestn.1120.

Full text

Abstract:

AbstractTheoretical background: Procalcitonin (PCT) is diagnostic and prognostic biomarker of sepsis. The objective of this study was to evaluate the correlation between sepsis causative agent and serum PCT concentration, since it would influence the initial empirical antimicrobial therapy selection.Methods: This retrospective study included 96 patients with sepsis who were admitted to Intensive Care Unit of Department of Infectious Diseases and Febrile Illnesses of University Clinical Center Ljubljana from September of 2011 through March of 2013. Sepsis was established clinically and defined aetiologically by haemoculture growth. Statistical evaluation was conducted in 76 patients who had not received proper antimicrobial therapy prior to blood collection. ForPCT determination imunoluminometric method was used and concentrations above 5 mg/L were considered elevated. Results: Serum PCT concentration was significantly higher in Gram-negative sepsis (PCT median was 26,3 μg/L) compared to Gram-positive sepsis (PCT median was 11,2 μg/L) (p = 0,016). Differences in PCT concentrations between Gram-positive pathogens were not statistically significant (p = 0,09), however, S. aureus sepsis is linked to higher serum PCT concentration (median PCT 12,8 μg/L) than all other Gram-positive agents put together (median PCT of 5,9 μg/L) (p = 0,016). Difference in PCT concentration in E. coli sepsis (median PCT of 38,2 μg/L) compared to other enterobacteria (median PCT of 26,3 μg/L) is not statistically significant (p = 0,902). Conclusions: Causative agent has a significant effect on serum PCT concentration in patients with sepsis. Higher values were present in Gram-negative than in Gram-positive sepsis. Amongst Gram-positive pathogens, S. aureus caused greater rise in PCT than other Gram-positive bacteria put together.

APA, Harvard, Vancouver, ISO, and other styles

34

Varga, Gergely, András Dávid Tóth, Virág Réka Szita, Zoltán Csukly, Apor Hardi, Júlia Gaál-Weisinger, Zsolt Nagy, et al. "Beneficial Effect of Lenalidomide-Dexamethason Treatment in Relapsed/Refractory Multiple Myeloma Patients: Results of Real-Life Data From 11 Hungarian Centers." Pathology and Oncology Research 27 (April 22, 2021). http://dx.doi.org/10.3389/pore.2021.613264.

Full text

Abstract:

In Hungary, the cost of lenalidomide-based therapy is covered only for relapsed multiple myeloma (MM) patients, therefore lenalidomide is typically used in the second-line either as part of a triplet with proteasome inhibitors or as a doublet. Lenalidomide-dexamethasone is a standard treatment approach for relapsed/refractory MM, and according to recent large randomized clinical trials (RCT, the standard arm of POLLUX, ASPIRE, TOURMALINE), the progression-free survival (PFS) is expected to be approximately 18 months. We surveyed ten Hungarian centers treating MM and collected data of 278 patients treated predominantly after 2016. The median age was 65 years, and patients were distributed roughly equally over the 3 international staging system groups, but patients with high risk cytogenetics were underrepresented. 15.8% of the patients reached complete response, 21.6% very good partial response, 40.6% partial response, 10.8% stable disease, and 2.5% progressed on treatment. The median PFS was unexpectedly long, 24 months, however only 9 months in those with high risk cytogenetics. We found interesting differences between centers regarding corticosteroid type (prednisolone, methylprednisolone or dexamethasone) and dosing, and also regarding the choice of anticoagulation, but the outcome of the various centers were not different. Although the higher equivalent steroid dose resulted in more complete responses, the median PFS of those having lower corticosteroid dose and methylprednisolone were not inferior compared to the ones with higher dose dexamethasone. On multivariate analysis high risk cytogenetics and the number of prior lines remained significant independent prognostic factors regarding PFS (p < 0.001 and p = 0.005). Our results show that in well-selected patients Lenalidomide-dexamethasone can be a very effective treatment with real-world results that may even outperform those reported in the recent RCTs. This real world information may be more valuable than outdated RCT data when treatment options are discussed with patients.

APA, Harvard, Vancouver, ISO, and other styles

35

Kopińska, A., A. Koclęga, A. Wieczorkiewicz-Kabut, K. Woźniczka, D. Kata, M. Włodarczyk, and G. Helbig. "Allogeneic Stem Cell Transplantation for Relapsed and Refractory Hodgkin Lymphoma: Real World Experience of a Single Center." Pathology and Oncology Research 27 (July 27, 2021). http://dx.doi.org/10.3389/pore.2021.1609867.

Full text

Abstract:

Introduction: Refractory and relapsed Hodgkin lymphoma (R/R HL) is associated with poor prognosis, and allogeneic stem cell transplantation (allo-SCT) remains the only potentially curative approach.Aim: The aim of the study was to evaluate the feasibility of allotransplantation in R/R HL setting.Material: Overall, 24 patients (17 men and 7 women) at a median age of 27 years (range 18–44) underwent allo-SCT between 2002 and 2020.Results: Nineteen patients received prior autologous stem cell transplantation (ASCT1) whereas eight patients received second ASCT (ASCT2) after failure of ASCT1. Six patients received only brentuximab vedotin (BV; n = 4) or BV followed by checkpoint inhibitors (CPI; n = 2) before entering allo-SCT. Median time from ASCT1 to allo-SCT was 17.1 months. Fifteen patients received grafts from unrelated donors. Peripheral blood was a source of stem cells for 16 patients. Reduced-intensity conditioning was used for all patients. Disease status at transplant entry was as follows: complete remission (CR; n = 4), partial response (PR; n = 10), and stable disease (SD; n = 10). Acute and chronic graft-versus-host disease (GVHD) developed in 13 (54%) and 4 (16%) patients, respectively. Median follow-up for the entire cohort was 13.3 months. At the last follow-up, 17 (71%) patients died. The main causes of death were disease progression (n = 10), infectious complications (n = 6), and steroid-resistant GVHD (n = 1). Non-relapse mortality at 12 months was 25%. At the last follow-up, seven patients were alive; six patients were in CR, and one had PR. The 2-year overall survival (OS) was 40%.Conclusion: Chemosensitive disease at transplant was associated with better outcome. Allo-SCT allows for long-term survival in refractory and relapsed HL.

APA, Harvard, Vancouver, ISO, and other styles

36

Yang, Hui, Kunlun Wang, Shenglei Li, Yan Li, and Ling Yuan. "The Prognostic Role of PORT and EGFR Mutation Status in Completely Resected Stage IIIA/N2 Non-Small Cell Lung Cancer Patients with Postoperative Chemotherapy." Pathology and Oncology Research 27 (August 10, 2021). http://dx.doi.org/10.3389/pore.2021.1609898.

Full text

Abstract:

Background: The treatment choice for completely resected stage IIIA/N2 non-small cell lung cancer (NSCLC) patients is still controversial now. Our study aims to identify potential prognostic factors in stage IIIA/N2 NSCLC patients with complete surgical resection and postoperative chemotherapy.Methods: In this study, we screened the stage IIIA/N2 NSCLC patients diagnosed in the Affiliated Cancer Hospital of Zhengzhou University from 2015 to 2019. Completely resected patients with postoperative chemotherapy (PCT) were enrolled. The univariate and multivariate COX proportional hazards regression analyses were used to identify the prognostic factors. The Kaplan-Meier survival curve was used to compare the disease-free survival (DFS) and overall survival (OS) in the subgroup analyses.Results: 180 patients were collected, including 142 patients with PCT treatment alone and 38 patients with postoperative radiotherapy (PORT) treatment. The median DFS was 17.8 months (95% CI: 16.5–19.1 months) and the median OS was 50.6 months (47.4–53.9 months) in all the patients. The median DFS of the PORT group was significantly longer than the PCT group (38.7 vs 16.7 months, p < 0.001). Epidermal growth factor receptor (EGFR) mutation-positive patients had a worse DFS compared with EGFR mutation-negative patients (16.8 vs 18.0 months, p = 0.032). Possible prognostic factors were evaluated through univariate COX regression analysis. The further multivariate COX regression analysis showed that patients with PORT (HR: 0.318, 95% CI: 0.185–0.547, p < 0.001), EGFR mutation-negative (HR: 0.678, 95% CI: 0.492–0.990, p = 0.044), T1 (HR: 0.661, 95% CI: 0.472–0.925, p = 0.016), and lobectomy (HR: 0.423, 95% CI: 0.191–0.935, p = 0.034), had better DFS. The only independent prognostic factor of OS was the type of surgery (p = 0.013).Conclusion: PORT might improve the DFS of stage IIIA/N2 NSCLC patients with complete surgical resection and PCT, but it cannot increase OS. Besides, EGFR mutation status, T stage, and type of surgery are possible independent prognostic factors for DFS, and type of surgery is associated with OS. These factors remain to be clarified in further studies.

APA, Harvard, Vancouver, ISO, and other styles

37

Wu, Yuqing, Saisai Chen, Minhao Zhang, Kuangzheng Liu, Jibo Jing, Kehao Pan, Lihua Zhang, Bin Xu, Xiaoming Lu, and Ming Chen. "Factors Associated with Survival From Xp11.2 Translocation Renal Cell Carcinoma Diagnosis—A Systematic Review and Pooled Analysis." Pathology and Oncology Research 27 (March 30, 2021). http://dx.doi.org/10.3389/pore.2021.610360.

Full text

Abstract:

Purpose: Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC) is a rare subtype of renal cell carcinoma (RCC), characterized by translocations of Xp11.2 breakpoints, involving of the transcription factor three gene (TFE3). The aim of our study was to comprehensively characterize the clinical characteristics and outcomes, and to identify risk factors associated with OS and PFS in Xp11.2 tRCC patients.Methods: Literature search on Xp11.2 tRCC was performed using databases such as pubmed EMBASE and Web of Science. Studies were eligible if outcomes data (OS and/or PFS) were reported for patients with a histopathologically confirmed Xp11.2 tRCC. PFS and OS were evaluated using the univariable and multivariable Cox regression model.Results: There were 80 eligible publications, contributing 415 patients. In multivariable analyses, the T stage at presentation was significantly associated with PFS (HR: 3.87; 95% CI: 1.70 to 8.84; p = 0.001). The median time of PFS was 72 months. In the multivariable analyses, age at diagnosis (HR: 2.16; 95% CI: 1.03 to 4.50; p = 0.041), T stage at presentation (HR: 4.44; 95% CI: 2.16 to 9.09; p < 0.001) and metastasis status at presentation (HR: 2.67; 95% CI: 1.12 to 6.41; p = 0.027) were all associated with OS, with a median follow-up time of 198 months.Conclusion: T stage at presentation is the only factor that is associated with both PFS and OS in patients with Xp11.2 tRCC. Also, patients over 45 or with metastases are more likely to have poorer OS.

APA, Harvard, Vancouver, ISO, and other styles

38

Lőcsei, Zoltán, Klára Sebestyén, Zsolt Sebestyén, Eszter Fehér, Dorottya Soltész, Zoltán Musch, and László Csaba Mangel. "IMAT-IGRT Treatment with Simultaneous Integrated Boost as Dose Escalation for Patients with Cervical Cancer: A Single Institution, Prospective Pilot Study." Pathology and Oncology Research 27 (March 24, 2021). http://dx.doi.org/10.3389/pore.2021.608446.

Full text

Abstract:

Purpose: The aim of this study was to introduce the simultaneous integrated boost (SIB) technique to assess the safety of replacement of the brachytherapy (BT) boost for ineligible patients with cervical cancer receiving radiochemotherapy (RCT).Methods: Fourteen patients were enrolled between 2015 and 2018. SIB was delivered using RapidArc technique at doses of 2.4 Gy per fraction during pelvic irradiation with 50.4/1.8 Gy in seven patients (to a total dose of 67.2 Gy) with limited volume disease. In 7 patients with a more advanced disease stage (>5 cm tumor, parametric invasion both sides), parametric boost therapy was added to the pelvic radiotherapy to a total dose of the macroscopic tumor of 79.2 Gy. All patients received simultaneous cisplatin-based chemotherapy for 5 cycles with a dosage of 40 mg/m2. We examined acute toxicity (CTCAE v4.1) and quality of life (EORTC QLQ30 and CX24). The tumor regression rate was evaluated with RECIST 1.1 after the first 3- to 4-months follow-up Magnetic Resonance Imaging (MRI) scan. We calculated the percentage of tumor regression rate and the local control during the follow-up period and evaluated the survival data.Results: Our patient data are presented at a median follow-up time of 24.5 months. During the treatment period, no grade 3 to 4 toxicity was observed. During the follow-up period, no late-onset toxicity was observed. The tumor regression rate at the first MRI scan was 95.31% on average. Disease free survival (DFS) during the median follow-up of 24 months was 98.6%.Conclusion: In patients with cervical cancer, the SIB technique is amenable as part of definitive RCT. Dose escalation with the SIB technique can be safely administered to cervical cancer patients during definitive RCT if BT is not feasible. However, further randomized clinical studies are needed to validate the method, so routine use of it cannot be recommended yet.

APA, Harvard, Vancouver, ISO, and other styles

39

Valdivia, Daniel, Danjouma Cheufou, Benjamin Fels, Stephan Puhlvers, Khaled Mardanzai, Mohamed Zaatar, Gerhard Weinreich, et al. "Potential Prognostic Value of Preoperative Leukocyte Count, Lactate Dehydrogenase and C-Reactive Protein in Thymic Epithelial Tumors." Pathology and Oncology Research 27 (April 21, 2021). http://dx.doi.org/10.3389/pore.2021.629993.

Full text

Abstract:

Thymic epithelial tumors are the most common mediastinal tumors. Surgery is the mainstay of treatment and complete resection provides the best survival rate. However, advanced tumors often require multimodality treatment and thus we analyzed the prognostic potential of routine circulating biomarkers that might help to risk-stratify patients beyond tumor stage and histology. Preoperative values for white blood cell count (WBC), C-reactive protein (CRP) and lactate dehydrogenase (LDH) were analyzed in 220 thymic epithelial tumor patients operated between 1999 and 2018. Increased CRP levels (>1 mg/dl) were significantly more often measured in thymic carcinoma and neuroendocrine tumors when compared to thymoma. LDH serum activity was higher in thymic neuroendocrine tumors when compared to thymoma or thymic carcinoma. The median disease specific survival was significantly longer in thymoma cases than in thymic carcinoma and neuroendocrine tumors. Increased preoperative LDH level (>240 U/L) associated with shorter survival in thymus carcinoma (HR 4.76, p = 0.0299). In summary, higher CRP associated with carcinoma and neuroendocrine tumors, while LDH increased primarily in neuroendocrine tumors suggesting that biomarker analysis should be performed in a histology specific manner. Importantly, preoperative serum LDH might be a prognosticator in thymic carcinoma and may help to risk stratify surgically treated patients in multimodal treatment regimens.

APA, Harvard, Vancouver, ISO, and other styles

40

Boér, Katalin, Zsuzsanna Kahán, László Landherr, Tibor Csőszi, Károly Máhr, Ágnes Ruzsa, Zsolt Horváth, Barna Budai, and Gábor Rubovszky. "Pathologic Complete Response Rates After Neoadjuvant Pertuzumab and Trastuzumab with Chemotherapy in Early Stage HER2-Positive Breast Cancer - Increasing Rates of Breast Conserving Surgery: A Real-World Experience." Pathology and Oncology Research 27 (May 4, 2021). http://dx.doi.org/10.3389/pore.2021.1609785.

Full text

Abstract:

Purpose: The neoadjuvant use of pertuzumab and trastuzumab with chemotherapy improves the pathologic complete response (pCR) in early HER2+ breast cancer. The aim of this study was to determine the pCR rate obtained with dual HER2 blockade in routine clinical practice. The secondary and tertiary objective was to investigate the impact of neoadjuvant systemic therapy (NST) on performing breast-conserving surgery and survival data.Methods: This was a multicentre, retrospective, observational study in patients with stage II and III HER2+ early breast cancer who received pertuzumab and trastuzumab-based NST. Data were collected from patients’ medical records.Results: Eighty-two patients were included in the study treated in 8 cancer centers in Hungary between March 2015 and January 2020. The study included women with a median age of 50.3 years. The majority of the patients (95%) received a sequence of anthracycline-based chemotherapy followed by docetaxel. pCR was achieved in 54% of the cases. As a result of NST a significant increase of conservative breast surgeries (33% vs. 3.6% planned, p = 0.0001) was observed. Ki67 expression and neutrophil-to-lymphocyte ratio (NLR) significantly predicted pCR. None of the variables were independent predictors of DFS.Conclusion: The pCR rate achieved in our study demonstrates the reproducibility of trial data in a real-world population. The rate of breast-conserving surgery was significantly increased.

APA, Harvard, Vancouver, ISO, and other styles

41

Dong, Yinlei, Junjie Tian, Bingqian Yan, Kun Lv, Ji Li, and Deliang Fu. "Liver-Metastasis-Related Genes are Potential Biomarkers for Predicting the Clinical Outcomes of Patients with Pancreatic Adenocarcinoma." Pathology and Oncology Research 27 (July 5, 2021). http://dx.doi.org/10.3389/pore.2021.1609822.

Full text

Abstract:

It is widely acknowledged that metastasis determines the prognosis of pancreatic adenocarcinoma (PAAD), and the liver is the most primary distant metastatic location of PAAD. It is worth exploring the value of liver-metastasis-related genetic prognostic signature (LM-PS) in predicting the clinical outcomes of PAAD patients post R0 resection. We collected 65 tumors and 165 normal pancreatic data from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression project (GTEx), respectively. Differentially expressed genes (DEGs) between primary tumor and normal pancreatic samples were intersected with DEGs between primary tumor samples with liver metastasis and those without new tumor events. The intersected 45 genes were input into univariate Cox regression analysis to identify the prognostic genes. Thirty-three prognostic liver-metastasis-related genes were identified and included in least absolute shrinkage and selection operator (LASSO) analysis to develop a seven-gene LM-PS, which included six risk genes (ANO1, FAM83A, GPR87, ITGB6, KLK10, and SERPINE1) and one protective gene (SMIM32). The PAAD patients were grouped into low- and high-risk groups based on the median value of risk scores. The LM-PS harbored an independent predictive ability to distinguish patients with a high-risk of death and liver metastasis after R0 resection. Moreover, a robust prognostic nomogram based on LM-PS, the number of positive lymph nodes, and histologic grade were established to predict the overall survival of PAAD patients. Besides, a transcription factor‐microRNA coregulatory network was constructed for the seven LM-PS genes, and the immune infiltration and genomic alterations were systematically explored in the TGCA-PAAD cohort.

APA, Harvard, Vancouver, ISO, and other styles

42

Jain, Deepali, Prerna Guleria, Varsha Singh, Rajinder Parshad, Sunil Kumar, Timo Gaiser, Katrin S. Kurz, et al. "GTF2I Mutation in Thymomas: Independence From Racial-Ethnic Backgrounds. An Indian/German Comparative Study." Pathology and Oncology Research 27 (August 23, 2021). http://dx.doi.org/10.3389/pore.2021.1609858.

Full text

Abstract:

Thymomas are the most frequent adult mediastinal cancers. Their etiology is unknown and their pathogenesis poorly understood. Racial, ethnic and environmental factors influence tumorigenesis in many cancers, but their role in thymomas remains unclear to date. In this study that included pretreatment thymoma cases from India and Germany (n = 37 and n = 77, respectively) we compared i) the prevalence of the thymoma-specific chromosome 7 c.74146970T > A mutation of the GTF2I gene in type A and AB thymomas; ii) epidemiological features; and iii) the frequency of myasthenia gravis (MG). Due to a known predominance of GTF2I mutation in A and AB histotypes, we included only a marginal number of type B thymomas as a control group in both cohorts. While the distribution of histological types between the cohorts was similar (p = 0.1622), Indian patients were strikingly younger (p < 0.0001; median age 50 vs. 65 years) and showed significantly lower tumour stage (Masaoka-Koga stage I) at primary diagnosis (p = 0.0005) than the German patients. In patients with known MG status (n = 17 in Indian and n = 25 in German cohort), a clear trend towards more frequent MG was observed in the Indian group (p = 0.0504; 48 vs. 82%). The prevalence of the GTF2I mutation (analysed in n = 34 Indian and n = 77 German patients) was identical in the two cohorts. We conclude that racial-ethnic and environmental factors do not significantly influence the most common molecular feature of thymomas but may have an impact on the timing of clinical presentation.

APA, Harvard, Vancouver, ISO, and other styles

43

Kelany, Mohamed, Thomas FE Barth, Dina Salem, and Marwa M. Shakweer. "Prevalence and Prognostic Implications of PD-L1 Expression in Soft Tissue Sarcomas." Pathology and Oncology Research 27 (July 1, 2021). http://dx.doi.org/10.3389/pore.2021.1609804.

Full text

Abstract:

Background: PD-L1 expression differs from 19 to 92% in various cancer subtypes. Its expression carries a worse prognostic value in various malignancies and could also be used as a predictive marker for immune checkpoint inhibitor response. This study aimed to explore the prevalence of PD-L1 expression in soft tissue sarcomas and the correlation of PD-L1 expression with clinicopathological features.Patients and Methods: The tissue samples of 50 patients with STS were tested for PD-L1 expression using immunohistochemistry (IHC). We followed a 6-step proportional scoring system. The patients were treated at Ain Shams University Hospital from 2011 to 2017. We also explored the correlation of PD-L1 expression with different clinical features of the patients. The chi-square test was used to calculate the differences among variables.Results: Twelve cases (24%) showed positive PD-L1 expression with the highest prevalence in rhabdomyosarcoma and desmoid tumors (2/2 and 2/3 cases, respectively), followed by GIST in 2/4 cases and liposarcoma in 3/11 cases. Patients with positive PD-L1 expression showed a trend for worse survival, with a median overall survival of 11 months vs. 19 months for patients with negative PD-L1 expression (p-value = 0.1) and a mean PFS of 6 months vs. 11 months for patients with negative PD-L1 expression (p-value = 0.1). However, these findings did not reach statistical significance.Conclusion: Although the results did not reach statistical significance due to the small number of cases, PD-L1 expression could represent a prognostic factor for poor outcome. Larger clinical trials are recommended for the validation of PD-L1 as a poor prognostic biomarker.

APA, Harvard, Vancouver, ISO, and other styles

44

Čerina, Dora, Višnja Matković, Kristina Katić, Ingrid Belac Lovasić, Robert Šeparović, Ivana Canjko, Blanka Jakšić, et al. "Precision Oncology in Metastatic Uterine Cancer; Croatian First-Year Experience of the Comprehensive Genomic Profiling in Everyday Clinical Practice." Pathology and Oncology Research 27 (September 27, 2021). http://dx.doi.org/10.3389/pore.2021.1609963.

Full text

Abstract:

Comprehensive genomic profiling (CGP) is gradually becoming an inevitable part of the everyday oncology clinical practice. The interpretation and optimal implementation of the results is one of the hot topics of modern-day oncology. According to the recent findings, uterine cancer harbors a high level of gene alterations but is still insufficiently explored. The primary goal of this project was to assess the proportion of patients with targetable mutations. Also, the aim was to define and emphasize potential opportunities as well as the problems we have faced in the first year of testing on the national level. We performed a multicentric, retrospective, nested cross-sectional analysis on the total population of Croatian patients with advanced/metastatic uterine cancer where the tumor CGP was performed during 2020. CGP of the tumor tissue of 32 patients revealed clinically relevant genomic alterations (CRGA) in 27 patients (84%) with a median of 3 (IQR 1-4) CRGA per patient. The most common CRGAs were those of phosphatide-inositol-3 kinases (PIK3) in 22 patients (69%), with 13/22 (59%) of those patients harboring PIK3CA mutation. The next most common CGRAs were ARID1A and PTEN mutations in 13 (41%) and 11 (34%) patients, respectively. Microsatellite status was determined as stable in 21 patients (66%) and highly unstable in 10 patients (31%). A high tumor mutational burden (≥10Muts/Mb) was reported in 12 patients (38%). CGP analysis reported some kind of targeted therapy for 28 patients (88%). CGP determined clinically relevant genomic alterations in the significant majority of patients with metastatic uterine cancer, defining it as a rich ground for further positioning and development of precision oncology.

APA, Harvard, Vancouver, ISO, and other styles

45

Cruz-Rico, Graciela, Alejandro Avilés-Salas, Xitlally Popa-Navarro, Luis Lara-Mejía, Rodrigo Catalán, Roberto Sánchez-Reyes, Dennis López-Sánchez, et al. "Association of Lung Adenocarcinoma Subtypes According to the IASLC/ATS/ERS Classification and Programmed Cell Death Ligand 1 (PD-L1) Expression in Tumor Cells." Pathology and Oncology Research 27 (April 8, 2021). http://dx.doi.org/10.3389/pore.2021.597499.

Full text

Abstract:

Background: Programmed cell death-ligand 1 (PD-L1) protein expression is one of the most extensively studied biomarkers in patients with non-small cell lung cancer (NSCLC). However, there is scarce information regarding its association with distinct adenocarcinoma subtypes. This study evaluated the frequency of PD-L1 expression according to the IASLC/ATS/ERS classification and other relevant histological and clinical features.Patients and Methods: PD-L1 expression was assessed by immunohistochemistry (IHC). According to its positivity in tumor cells membrane, we stratified patients in three different tumor proportions score (TPS) cut-off points: a) <1% (negative), b) between 1 and 49%, and c) ≥50%; afterward, we analyzed the association among PD-L1 expression and lung adenocarcinoma (LADC) predominant subtypes, as well as other clinical features. As an exploratory outcome we evaluated if a PD-L1 TPS score ≥15% was useful as a biomarker for determining survival.Results: A total of 240 patients were included to our final analysis. Median age at diagnosis was 65 years (range 23–94 years). A PD-L1 TPS ≥1% was observed in 52.5% of the entire cohort; regarding specific predominant histological patterns, a PD-L1 TPS ≥1 was documented in 31.2% of patients with predominant-lepidic pattern, 46.2% of patients with predominant-acinar pattern, 42.8% of patients with a predominant-papillary pattern, and 68.7% of patients with predominant-solid pattern (p = 0.002). On the other hand, proportion of tumors with PD-L1 TPS ≥50% was not significantly different among adenocarcinoma subtypes. At the univariate survival analysis, a PD-L1 TPS cut-off value of ≥15% was associated with a worse PFS and OS.Conclusion: According to IASLC/ATS/ERS lung adenocarcinoma classification, the predominant-solid pattern is associated with a higher proportion of PD-L1 positive samples, no subtype was identified to be associated with a high (≥50%) TPS PD-L1.

APA, Harvard, Vancouver, ISO, and other styles

46

Ma, Weijun, Weidong Li, Lei Xu, Lu Liu, Yu Xia, Liping Yang, and Mingxu Da. "Identification of a Gene Prognostic Model of Gastric Cancer Based on Analysis of Tumor Mutation Burden." Pathology and Oncology Research 27 (September 10, 2021). http://dx.doi.org/10.3389/pore.2021.1609852.

Full text

Abstract:

Introduction: Gastric cancer is one of the most common cancers. Although some progress has been made in the treatment of gastric cancer with the improvement of surgical methods and the application of immunotherapy, the prognosis of gastric cancer patients is still unsatisfactory. In recent years, there has been increasing evidence that tumor mutational load (TMB) is strongly associated with survival outcomes and response to immunotherapy. Given the variable response of patients to immunotherapy, it is important to investigate clinical significance of TMB and explore appropriate biomarkers of prognosis in patients with gastric cancer (GC).Material and Methods: All data of patients with gastric cancer were obtained from the database of The Cancer Genome Atlas (TCGA). Samples were divided into two groups based on median TMB. Differently expressed genes (DEGs) between the high- and low-TMB groups were identified and further analyzed. We identified TMB-related genes using Lasso, univariate and multivariate Cox regression analysis and validated the survival result of 11 hub genes using Kaplan-Meier Plotter. In addition, “CIBERSORT” package was utilized to estimate the immune infiltration.Results: Single nucleotide polymorphism (SNP), C > T transition were the most common variant type and single nucleotide variant (SNV), respectively. Patients in the high-TMB group had better survival outcomes than those in the low-TMB group. Besides, eleven TMB-related DEGs were utilized to construct a prognostic model that could be an independent risk factor to predict the prognosis of patients with GC. What’s more, the infiltration levels of CD4+ memory-activated T cells, M0 and M1 macrophages were significantly increased in the high-TMB group compared with the low-TMB group.Conclusions: Herein, we found that patients with high TMB had better survival outcomes in GC. In addition, higher TMB might promote immune infiltration, which could provide new ideas for immunotherapy.

APA, Harvard, Vancouver, ISO, and other styles

47

Zhang, Ning, Yiwen Liu, Hong Yang, Mengxia Liang, Xiaopeng Wang, Min Wang, Jinyu Kong, Xiang Yuan, and Fuyou Zhou. "Clinical Significance of Fusobacterium nucleatum Infection and Regulatory T Cell Enrichment in Esophageal Squamous Cell Carcinoma." Pathology and Oncology Research 27 (July 9, 2021). http://dx.doi.org/10.3389/pore.2021.1609846.

Full text

Abstract:

A variety of pathogenic microorganisms promote tumor occurrence and development through long-term colonization in the body. Fusobacterium nucleatum (F. nucleatum) is abundant in precancerous esophageal lesions and is closely related to the malignant progression of esophageal squamous cell carcinoma (ESCC). The invasion of exogenous microorganisms can reshape the immune microenvironment, make the immune system incapacitated, and assist tumor cells in immune escape. A variety of pathogenic microorganisms induce the recruitment of regulatory T cell (Tregs) to allow tumor cells to escape immune surveillance and provide favorable conditions for their own long-term colonization. Tregs are one of the major obstacles to tumor immunotherapy and have a significant positive correlation with the occurrence and development of many kinds of tumors. Because F. nucleatum can instantly enter cells and colonize for a long time, we speculated that F. nucleatum infection could facilitate the immune escape of tumor cells through enrichment of Tregs and promote the malignant progression of ESCC. In this study, we found a significant concordance between F. nucleatum infection and Tregs infiltration. Therefore, we propose the view that chronic infection of F. nucleatum may provide favorable conditions for long-term colonization of itself by recruiting Tregs and suppressing the immune response. At the same time, the massive enrichment of Treg may also weaken the immune response and assist in the long-term colonization of F. nucleatum. We analyzed the correlation between F. nucleatum infection with the clinicopathological characteristics and survival prognosis of the patients. F. nucleatum infection was found to be closely related to sex, smoking, drinking, degree of differentiation, depth of invasion, lymph node metastasis, and clinical stage. The degree of differentiation, depth of infiltration, lymph node metastasis, clinical stage, and F. nucleatum infection are independent risk factors affecting ESCC prognosis. Additionally, the survival rate and median survival time were significantly shortened in the F. nucleatum infection positive group. Therefore, we propose that long-term smoking and alcohol consumption cause poor oral and esophageal environments, thereby significantly increasing the risk of F. nucleatum infection. In turn, F. nucleatum infection and colonization may weaken the antitumor immune response through Treg enrichment and further assist in self-colonization, promoting the malignant progression of ESCC.

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!