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1

Kayacan, Mehmet C., Yakup B. Baykal, Tamer Karaaslan, et al. "Monitoring the osseointegration process in porous Ti6Al4V implants produced by additive manufacturing: an experimental study in sheep." Journal of Applied Biomaterials & Functional Materials 16, no. 2 (2017): 68–75. http://dx.doi.org/10.5301/jabfm.5000385.

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Background: This study investigated the design and osseointegration process of transitive porous implants that can be used in humans and all trabecular and compact bone structure animals. The aim was to find a way of forming a strong and durable tissue bond on the bone–implant interface. Methods: Massive and transitive porous implants were produced on a direct metal laser sintering machine, surgically implanted into the skulls of sheep and kept in place for 12 weeks. At the end of the 12-week period, the Massive and porous implants removed from the sheep were investigated by scanning electron
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2

Karlsson, Kaj H., Heimo Ylänen, and Hannu Aro. "Porous bone implants." Ceramics International 26, no. 8 (2000): 897–900. http://dx.doi.org/10.1016/s0272-8842(00)00033-x.

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3

Silva de Medeiros, Waléria, Marize Varella de Oliveira, and José Mauro Granjeiro. "Evaluation of Biomimetic Solution for Coating Powder Metallurgy Porous Titanium Samples." Materials Science Forum 591-593 (August 2008): 703–7. http://dx.doi.org/10.4028/www.scientific.net/msf.591-593.703.

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In order to improve implant-bone attachment, porous titanium has been used to achieve the ingrowth of bone tissue within the porous structure. Although this biomaterial has shown efficient bone adhesion for orthopedic and dental implants, the ideal surface must have chemical bonds at the implant-bone interface. In this work, samples of pure porous titanium were produced by powder metallurgy technique and submitted to biomimetic process in order to evaluate the material’s bioactivity and to enhance its osteoconductivity. The samples were immersed in modified simulated body fluid (mSBF) which in
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4

Miao, X. "Modification of Porous Alumina Ceramics with Bioinert and Bioactive Glass Coatings." Advanced Materials Research 32 (February 2008): 211–14. http://dx.doi.org/10.4028/www.scientific.net/amr.32.211.

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Porous biomaterials including porous bioceramics play important roles for hard tissue replacement and regeneration. I this paper, porous alumina (with and without zirconia addition) ceramics were produced via coating polyurethane (PU) foams with Al2O3 (ZrO2) slurries, followed by drying at room temperature and sintering at 1300 oC. The advantage of the PU foam method was the achieved high pore interconnectivity, but the mechanical properties of the porous ceramics were rather poor due to the high macroporosity and the high microporosity. To remove the microporosity and strengthen the porous al
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Nguyen Xuan Thanh, Tram, Michito Maruta, Kanji Tsuru, Shigeki Matsuya, and Kunio Ishikawa. "Three-Dimensional Porous Carbonate Apatite with Sufficient Mechanical Strength as a Bone Substitute Material." Advanced Materials Research 891-892 (March 2014): 1559–64. http://dx.doi.org/10.4028/www.scientific.net/amr.891-892.1559.

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In this study, three - dimensional porous carbonate apatite (CO3Ap) materials with the chemical compositions and structures similar to cancellous bone were produced via phosphorization of porous calcite precursor in hydrothermal condition. In order to make porous calcite precursor, negative replication of polyurethane foam that named as inverse ceramic foam method was conducted. When the polyurethane template occupied within the ceramic solid walls disappeared due to burning at high temperature, interconnected hollow pathways were produced. Polyurethane foam was used as a porogen - template fi
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Dawson, Eileen, Richard Suzuki, Melissa Samano, and Matthew Murphy. "Increased Internal Porosity and Surface Area of Hydroxyapatite Accelerates Healing and Compensates for Low Bone Marrow Mesenchymal Stem Cell Concentrations in Critically-Sized Bone Defects." Applied Sciences 8, no. 8 (2018): 1366. http://dx.doi.org/10.3390/app8081366.

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For clinical treatment of skeletal defects, osteoinductive scaffolds must have the ability to conform to the unique geometry of the injury site without sacrificing biologically favorable properties, including porosity. This investigation seeks to combine the osteoinductive properties of porous hydroxyapatite (HA) scaffolds with the beneficial handling characteristics of granules or putties, while evaluating the effects of mesenchymal stem cell (MSC) concentration on the composite grafts’ ability to regenerate bone in vivo. The results demonstrate that porous HA granules regenerate significantl
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Goia, Tamiye Simone, Kalan Bastos Violin, Carola Gomez Ágreda, José Carlos Bressiani, and Ana Helena de Almeida Bressiani. "Bone Tissue Response in a Metallic Bone Architecture Microstructure." Journal of Biomimetics, Biomaterials and Biomedical Engineering 20 (June 2014): 73–85. http://dx.doi.org/10.4028/www.scientific.net/jbbbe.20.73.

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Porous metallic structures have been developed to mimic the natural bone architecture, having interconnected porosity, disposing enough room to cell migration, anchoring, vascularization, nourishing and proliferation of new bone tissue. Research involving porous titanium has been done with purpose to achieve desirable porosity and increasing of bone-implant bond strength interface. Samples of titanium were prepared by powder metallurgy (PM) with addition of different natural polymers (cornstarch, rice starch, potato starch and gelatin) at proportion of 16wt%. In aqueous solution the hydrogenat
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8

Zhao, Li Sheng, Zheng Wang, Ke Ya Mao та ін. "Preparation and Properties of Porous β–Tricalcium Phosphate Bone Graft". Advanced Materials Research 624 (грудень 2012): 226–30. http://dx.doi.org/10.4028/www.scientific.net/amr.624.226.

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The need for bone repair has increased as the population ages. However, currently, the bone grafts still have some disadvantages, such as low compressive strength and porosity, which limit their use. In order to solve these disadvantages, in this study, the porous beta-tricalcium phosphate (β-TCP) anorganic bone graft were prepared from healthy bovine cancellous bone by cell-free, defat and twice calcinations. X-ray diffraction (XRD) was used to investigate the chemical composition of the bone graft. And the morphology, porosity and mechanical strength of the bone graft were also evaluated. Th
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Wang, Yanying, Xiaodi Sun, Qingfu Wang, et al. "In vitro and in vivo evaluation of porous chitosan electret membrane for bone regeneration." Journal of Bioactive and Compatible Polymers 33, no. 4 (2018): 426–38. http://dx.doi.org/10.1177/0883911518774814.

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A porous chitosan electret membrane, possessing a three-dimensional porous structure and surface charges, was developed using thermally induced phase separation method and grid-controlled corona charging. Results showed that surface charge release of porous electret membrane could be altered by varying charging voltage. Rat osteoblasts adhered well, and cell proliferation and differentiation were enhanced by porous electret membrane compared to porous uncharged membrane. Furthermore, rabbit calvarial defects model demonstrated that porous electret membrane promoted bone regeneration more signi
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10

Hasegawa, Shin, Jiro Tamura, Masashi Neo, et al. "In Vivo Evaluation of Porous Hydroxyapatite/Poly D/L-Lactide Composite for Bone Substitute and Scaffold." Key Engineering Materials 284-286 (April 2005): 769–74. http://dx.doi.org/10.4028/www.scientific.net/kem.284-286.769.

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We investigated the biocompatibility, osteoconductivity, and biodegradability of porous composite of Hydroxyapatite (HA) and Poly D/L-lactide (PDLLA). At 6weeks afterimplantation to rabbit femoral condyle, HA/PDLLA was covered with bone and contacted with bone directly. The amounts of newly formed bone in the pores had increased during the examined period. By 26weeks, bone remodeling of formed bone in the pores was seen and bone marrow tissue formation was seen in the pores of HA/PDLLA. Porous HA/PDLLA was resorbed much faster than porous HA as a control. Porous HA/PDLLA was resorbed constantl
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11

Zhang, Yongde, Peter B. Ahn, Daniel C. Fitzpatrick, Anneliese D. Heiner, Robert A. Poggie, and Thomas D. Brown. "INTERFACIAL FRICTIONAL BEHAVIOR: CANCELLOUS BONE, CORTICAL BONE, AND A NOVEL POROUS TANTALUM BIOMATERIAL." Journal of Musculoskeletal Research 03, no. 04 (1999): 245–51. http://dx.doi.org/10.1142/s0218957799000269.

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A laboratory test was undertaken to evaluate the interfacial frictional characteristics of cortical and cancellous bone, as well as a novel porous tantalum biomaterial (Hedrocel®, Implex Corp.). Three sets of tests were conducted to measure the friction coefficients of (1) bovine cancellous bone against bovine cortical bone; (2) net-shape formed porous tantalum against bovine cortical and cancellous bone; and (3) electron-discharge-machine formed (EDM'd) porous tantalum against bovine cortical and cancellous bone. The bovine cortical bone was tested in three conditions: periosteum-intact, peri
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12

He, Si, Jiang Zhu, Yiwan Jing, et al. "Effect of 3D-Printed Porous Titanium Alloy Pore Structure on Bone Regeneration: A Review." Coatings 14, no. 3 (2024): 253. http://dx.doi.org/10.3390/coatings14030253.

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As a biomedical material, porous titanium alloy has gained widespread recognition and application within the field of orthopedics. Its remarkable biocompatibility, bioactivity, and mechanical properties establish it as a promising material for facilitating bone regeneration. A well-designed porous structure can lower the material’s modulus while retaining ample strength, rendering it more akin to natural bone tissue. The progression of additive manufacturing (AM) technology has significantly propelled the advancement of porous implants, simplifying the production of such structures. AM allows
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13

Zhang, Xuesong, Guoquan Zheng, Jiaqi Wang, et al. "Porous Ti6Al4V Scaffold Directly Fabricated by Sintering: Preparation andIn VivoExperiment." Journal of Nanomaterials 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/205076.

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The interface between the implant and host bone plays a key role in maintaining primary and long-term stability of the implants. Surface modification of implant can enhance bone ingrowth and increase bone formation to create firm osseointegration between the implant and host bone and reduce the risk of implant losing. This paper mainly focuses on the fabricating of 3-dimensiona interconnected porous titanium by sintering of Ti6Al4V powders, which could be processed to the surface of the implant shaft and was integrated with bone morphogenetic proteins (BMPs). The structure and mechanical prope
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14

Arsista, Dede, Yosi Kusuma Eriwati, Siti Triaminingsih, and Sunarso Sunarso. "The Use of Sucrose Granule as Pore Maker in Preparation of Porous Calcium Sulfate Dihydrate." Key Engineering Materials 829 (December 2019): 75–80. http://dx.doi.org/10.4028/www.scientific.net/kem.829.75.

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Calcium sulfate dihydrate (CSD) has been clinically used as bone filler for decades. CSD bone graft is cheap, biocompatible and can be transformed to other osteoconductive ceramics such as hydroxyapatite and carbonate apatite. In addition, porous ceramic bone grafts is desired clinically. Development of porous ceramics bone graft with simple and cost-effective method is preferred. Thus, in this study, porous CSD was developed. Porous CSD can be used both as bone filler or precursor for porous hydroxyapatite and carbonate apatite. Porous CSD was prepared by mixing calcium sulfate hemihydrate (C
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15

Koju, Naresh, Suyash Niraula, and Behzad Fotovvati. "Additively Manufactured Porous Ti6Al4V for Bone Implants: A Review." Metals 12, no. 4 (2022): 687. http://dx.doi.org/10.3390/met12040687.

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Ti-6Al-4V (Ti64) alloy is one of the most widely used orthopedic implant materials due to its mechanical properties, corrosion resistance, and biocompatibility nature. Porous Ti64 structures are gaining more research interest as bone implants as they can help in reducing the stress-shielding effect when compared to their solid counterpart. The literature shows that porous Ti64 implants fabricated using different additive manufacturing (AM) process routes, such as laser powder bed fusion (L-PBF) and electron beam melting (EBM) can be tailored to mimic the mechanical properties of natural bone.
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16

Jones, Julian R., Peter D. Lee, and Larry L. Hench. "Hierarchical porous materials for tissue engineering." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 364, no. 1838 (2005): 263–81. http://dx.doi.org/10.1098/rsta.2005.1689.

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Biological organisms have evolved to produce hierarchical three-dimensional structures with dimensions ranging from nanometres to metres. Replicating these complex living hierarchical structures for the purpose of repair or replacement of degenerating tissues is one of the great challenges of chemistry, physics, biology and materials science. This paper describes how the use of hierarchical porous materials in tissue engineering applications has the potential to shift treatments from tissue replacement to tissue regeneration. The criteria that a porous material must fulfil to be considered ide
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17

Zhang, Chunyu, and Yuehong Wang. "Biomechanical Analysis of Axial Gradient Porous Dental Implants: A Finite Element Analysis." Journal of Functional Biomaterials 14, no. 12 (2023): 557. http://dx.doi.org/10.3390/jfb14120557.

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The porous structure can reduce the elastic modulus of a dental implant and better approximate the elastic characteristics of the material to the alveolar bone. Therefore, it has the potential to alleviate bone stress shielding around the implant. However, natural bone is heterogeneous, and, thus, introducing a porous structure may produce pathological bone stress. Herein, we designed a porous implant with axial gradient variation in porosity to alleviate stress shielding in the cancellous bone while controlling the peak stress value in the cortical bone margin region. The biomechanical distri
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18

Yang, Xue, Xiujuan Song, Guoliang Zhang, et al. "Design, analysis and optimization of porous titanium alloys scaffolds by using additive manufacture." International Journal for Simulation and Multidisciplinary Design Optimization 15 (2024): 16. http://dx.doi.org/10.1051/smdo/2024013.

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In order to have a stronger bond with the surrounding bone, the bone prosthesis needs to have interconnecting pores for bone cells to grow and more importantly to avoid stress shielding. At the same time, human bones have different composition and structure of bone tissue in different parts of the body due to different physical factors of the person, so the elastic modulus of the bones that need to be supported and replaced are not the same. And additive manufacturing has the advantages of rapid, efficient and precise manufacturing of complex shapes and high-quality three-dimensional structure
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19

Uklejewski, Ryszard, Mariusz Winiecki, and Piotr Rogala. "Computer Aided Stereometric Evaluation of Porostructuralosteoconductive Properties of Intra-Osseous Implant Porous Coatings." Metrology and Measurement Systems 20, no. 3 (2013): 431–42. http://dx.doi.org/10.2478/mms-2013-0037.

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Abstract The proper interaction of bone tissue - the natural porous biomaterial - with a porous coated intra-osseous implant is conditioned, among others, by the implant porous coating poroaccessibility for bone tissue adaptive ingrowth. The poroaccessibility is the ability of implant porous coating outer layer to accommodate the ingrowing bone tissue filling in its pore space and effective new formed bone mineralizing in the pores to form a biomechanically functional bone-implant fixation. The functional features of the microtopography of intra-osseous implant porous surfaces together with th
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20

Cheong, Vee San, Paul Fromme, Melanie J. Coathup, Aadil Mumith, and Gordon W. Blunn. "Partial Bone Formation in Additive Manufactured Porous Implants Reduces Predicted Stress and Danger of Fatigue Failure." Annals of Biomedical Engineering 48, no. 1 (2019): 502–14. http://dx.doi.org/10.1007/s10439-019-02369-z.

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Abstract New porous implant designs made possible by additive manufacturing allow for increased osseointegration, potentially improving implant performance and longevity for patients that require massive bone implants. The aim of this study was to evaluate how implantation and the strain distribution in the implant affect the pattern of bone ingrowth and how changes in tissue density within the pores alter the stresses in implants. The hypothesis was that porous metal implants are susceptible to fatigue failure, and that this reduces as osteointegration occurs. A phenomenological, finite eleme
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Xu, Shubo, Hailong Ma, Xiujuan Song, Sen Zhang, Xinzhi Hu, and Zixiang Meng. "Finite Element Simulation of Stainless Steel Porous Scaffolds for Selective Laser Melting (SLM) and Its Experimental Investigation." Coatings 13, no. 1 (2023): 134. http://dx.doi.org/10.3390/coatings13010134.

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In recent years, bone defect and bone tissue damage have become common clinical diseases. The development of bionic bone has had an important impact on the repair and reconstruction of bone tissue. Porous scaffolds have the advantages of adjustable pore size and controllable shape, which can solve the problem of mismatch in the process of bone repair, but traditional processing methods cannot overcome the challenge of the preparation of complex porous scaffolds. Therefore, 316L porous stainless steel scaffolds with different pore sizes (200 μm, 300 μm, 400 μm and 500 μm, respectively) were pre
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22

Takemoto, Mitsuru, Shunsuke Fujibayashi, Tomiharu Matsushita, J. Suzuki, Tadashi Kokubo, and Takashi Nakamura. "Mechanical Properties and Osteoconductivity of Porous Bioactive Titanium Metal." Key Engineering Materials 284-286 (April 2005): 263–66. http://dx.doi.org/10.4028/www.scientific.net/kem.284-286.263.

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Porous bioactive titanium implant was produced by plasma-spray method and succeeding chemical and thermal treatment. This porous titanium implant possess a porosity of 40% and complex interconnective porous structure. Mechanical property of porous titanium was characterized for compressive and 4-point bending properties, as well as compressive fatigue. Bone tissue response and biocompatibility of porous bioactive titanium implant was evaluated by in vivo osteoconductive model. Ultimate compression strength and bending strength were 280 and 101 MPa. Bone ingrowth showed significant increases in
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Herliansyah, Muhammad Kusumawan, Suyitno, Punto Dewo, Mohd Hamdi Bin Abdul Shukor, and A. Ide-Ektessabi. "Development and Characterization of Bovine Hydroxyapatite Porous Bone Graft for Biomedical Applications." Advanced Materials Research 277 (July 2011): 59–65. http://dx.doi.org/10.4028/www.scientific.net/amr.277.59.

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The porous Hydroxyapatite (HA) ceramics have found enormous use in biomedical applications including bone tissue regeneration, cell proliferation, and drug delivery. This paper investigates the preparation and characterization of bovine Hydroxyapatite (BHA) porous bone graft by mixing sucrose powder as porogens with bovine bone powder. After uniaxially pressing at 156 MPa and pressurelessly sintering in air atmosphere at 1200°C for 2 hours the bioceramic showed an interconnecting porosity. The XRD analysis indicated that bovine hydroxyapatite (BHA) porous bone graft resulted in this research i
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Yoon, J. H., J. H. Park, Eui Kyun Park, et al. "Osteogenic Repair by Bovine Bone Ash Derived Porous HA Ceramic Formed by Foaming Method." Key Engineering Materials 342-343 (July 2007): 633–36. http://dx.doi.org/10.4028/www.scientific.net/kem.342-343.633.

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To develop a suitable scaffold optimizing bone regeneration, we developed bovine bone ash derived fully connected porous HA ceramic scaffolds adopting a foaming method. They revealed excellent biocompatibility. The attached cells on the scaffolds proliferated in multi-layers with osteoblastic differentiation. The bone defects grafted with bovine bone ash derived fully interconnected porous HA ceramics having average 500 μm sized spherical pores and average 150 μm sized interconnecting interpores with average 80% porosity were favorably healed without any pathologic changes within 3 weeks. New
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Resende-Gonçalves, Cláudia Inês, Nuno Sampaio, Joaquim Moreira, et al. "Porous Zirconia Blocks for Bone Repair: An Integrative Review on Biological and Mechanical Outcomes." Ceramics 5, no. 1 (2022): 161–72. http://dx.doi.org/10.3390/ceramics5010014.

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The aim of this study was to conduct an integrative review of the biological and mechanical outcomes of porous zirconia structures for extensive bone repair. An electronic search was performed on the PubMed database using a combination of the following scientific terms: porous, scaffold, foam, zirconia, bone regeneration, bone repair, bone healing. Articles published in the English language up to December 2021 and related to porosity, pore interconnectivity, biocompatibility and strength of the material, and the manufacturing methods of zirconia porous structures were included. Randomized cont
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Phuoc, Hung Do, Phu Nguyen Hoang, Sam Yang, Darren Fraser, and Vu Thua Nguyen. "Osseointegrability of 3D-printed porous titanium alloy implant on tibial shaft bone defect in rabbit model." PLOS ONE 18, no. 9 (2023): e0282457. http://dx.doi.org/10.1371/journal.pone.0282457.

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Previous studies have demonstrated the ability of osseointegration of porous titanium implants in cancellous bone. Our study was designed to (i) investigate the ability of bone ingrowth into 3D-printed porous titanium alloy implant on the cortical bone of rabbits using CT-scan and histology, and (ii) to identify the consistency of the radiology information between clinical Cone Beam Computed Tomography (CBCT) and Micro Computed Tomography (μCT) in the evaluation of bone ingrowth. The porous titanium alloy implants were 3D-printed employing the Electron Beam Melting (EBM) technology with an int
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Alshehri, Fahad, Mohammed Alshehri, Terrence Sumague, et al. "Evaluation of Peri-Implant Bone Grafting Around Surface-Porous Dental Implants: An In Vivo Study in a Goat Model." Materials 12, no. 21 (2019): 3606. http://dx.doi.org/10.3390/ma12213606.

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Dental implants with surface-porous designs have been recently developed. Clinically, peri-implant bone grafting is expected to promote early osseointegration and bone ingrowth when applied with surface-porous dental implants in challenging conditions. The aim of this study was to comparatively analyze peri-implant bone healing around solid implants and surface-porous implants with and without peri-implant bone grafting, using biomechanical and histomorphometrical assessment in a goat iliac bone model. A total of 36 implants (4.1 mm wide, 11.5 mm long) divided into three groups, solid titanium
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Matsuzaki, Akio, Kenji Shitama, Keisuke Ota, and Yoshio Araki. "Porous Hydroxyapatite as artificial bone." Orthopedics & Traumatology 35, no. 4 (1987): 1465–67. http://dx.doi.org/10.5035/nishiseisai.35.1465.

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Abbasi, Naghmeh, Stephen Hamlet, Robert M. Love, and Nam-Trung Nguyen. "Porous scaffolds for bone regeneration." Journal of Science: Advanced Materials and Devices 5, no. 1 (2020): 1–9. http://dx.doi.org/10.1016/j.jsamd.2020.01.007.

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Simske, S. J., R. A. Ayers, and T. A. Bateman. "Porous Materials for Bone Engineering." Materials Science Forum 250 (September 1997): 151–82. http://dx.doi.org/10.4028/www.scientific.net/msf.250.151.

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31

Bobik, G., J. Żmudzki, and K. Majewska. "Bone tissue loads around titanium femoral implant and coated with porous layer." Journal of Achievements in Materials and Manufacturing Engineering 2, no. 90 (2018): 77–84. http://dx.doi.org/10.5604/01.3001.0012.8386.

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Purpose: Difference in the mechanical properties of bone and stiffer femoral implant causes bone tissue resorption, which may result in implant loosening and periprosthetic fractures. The introduction of porous material reduces the stiffness of the implant. The aim of the study was to analyse the influence of porous shell of femoral revision implant on bone tissue loading distribution with use the finite element method. Design/methodology/approach: Load transfer in the femur has been investigated using the finite element method (Ansys). Cementless implant models were placed in the anatomical f
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Pramuková Vilčeková, Zuzana, Monika Kašiarová, Magdaléna Precnerová Domanická, Miroslav Hnatko, and Pavol Šajgalík. "Local Mechanical Properties of Highly Porous Si3N4 for Trabecular Bone Replacement." Key Engineering Materials 662 (September 2015): 142–46. http://dx.doi.org/10.4028/www.scientific.net/kem.662.142.

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The study deals with the development of highly porous undegradable ceramics based on silicon nitride as potential replacement of trabecular bone. These materials were produced using replication method with polyurethane foams as pore-forming agents to achieve similar porous structure to trabecular bone. Prepared porous ceramics had a bimodal pore structure with macro-pores larger than 200 μm and micro-pores smaller than 1 μm in diameter, which are necessary for tissue ingrowths, cell adhesion, adsorption of biological metabolites and nutrition delivery in organism. The microstructure and local
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33

Alessandri, Giulia, Gian Maria Santi, Paolo Martelli, Eleonora Guidotti, and Alfredo Liverani. "3D-printing of porous structures for reproduction of a femoral bone." F1000Research 12 (January 6, 2023): 17. http://dx.doi.org/10.12688/f1000research.129267.1.

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Background: 3D-printing has shown potential in several medical advances because of its ability to create patient-specific surgical models and instruments. In fact, this technology makes it possible to acquire and study physical models that accurately reproduce patient-specific anatomy. The challenge is to apply 3D-printing to reproduce the porous structure of a bone tissue, consisting of compact bone, spongy bone and bone marrow. Methods: An interesting approach is presented here for reproducing the structure of a bone tissue of a femur by 3D-printing porous structure. Through the process of C
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Kokot, G., K. Skalski, A. Makuch, and W. Ogierman. "Digital Image Correlation and nanoindentation in evaluation of material parameters of cancellous bone microstructure." Archives of Materials Science and Engineering 1, no. 83 (2017): 10–16. http://dx.doi.org/10.5604/01.3001.0009.7536.

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Purpose: Purpose of this paper is to present the possibilities of the application of the two methods: Digital Image Correlation and nanoindentation in porous bone tissues testing. Firstly, as a tool in the evaluation process of material parameters for porous microstructures, such as bone tissues or other foams and, secondly, as validation and verification tools for finite element analysis of bone or foams structures. Those methods are helpful when the high accuracy of the mechanical parameters of porous microstructures is required.Design/methodology/approach: Two methods: Digital Image Correla
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Suzuki, Yuko, Naoyuki Nomura, Shuji Hanada, et al. "Osteoconductivity of Porous Titanium Having Young’s Modulus Similar to Bone and Surface Modification by OCP." Key Engineering Materials 330-332 (February 2007): 951–54. http://dx.doi.org/10.4028/www.scientific.net/kem.330-332.951.

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The present study was designed to investigate whether porous titanium (Ti) having Young’s modulus similar to bone has osteoconductive characteristics in rat critical-sized calvarial bone defect. The effect of coating by octacalcium phosphate (OCP) was also examined. OCP is known as a precursor of initial mineral crystals of biological apatite in bones and teeth. Ti powder was prepared by plasma rotating electrode process in an Ar atmosphere. Then, porous Ti disks, 8 mm in diameter with 1 mm thick, were obtained using the particles ranging from 300 to 500 +m, by sintering at 1573 K without appl
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Wang, Weiwei, Xiaqing Zhou, Zhuozhuo Yin, and Xiaojun Yu. "Fabrication and Evaluation of Porous dECM/PCL Scaffolds for Bone Tissue Engineering." Journal of Functional Biomaterials 14, no. 7 (2023): 343. http://dx.doi.org/10.3390/jfb14070343.

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Porous scaffolds play a crucial role in bone tissue regeneration and have been extensively investigated in this field. By incorporating a decellularized extracellular matrix (dECM) onto tissue-engineered scaffolds, bone regeneration can be enhanced by replicating the molecular complexity of native bone tissue. However, the exploration of porous scaffolds with anisotropic channels and the effects of dECM on these scaffolds for bone cells and mineral deposition remains limited. To address this gap, we developed a porous polycaprolactone (PCL) scaffold with anisotropic channels and functionalized
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Zou, Zhenhao, Vee San Cheong, and Paul Fromme. "BONE REMODELLING PREDICTION FOR IMPROVED POROUS IMPLANT DESIGN." Orthopaedic Proceedings 105-B, SUPP_16 (2023): 26. http://dx.doi.org/10.1302/1358-992x.2023.16.026.

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AbstractObjectivesYoung patients receiving metallic bone implants after surgical resection of bone cancer require implants that last into adulthood, and ideally life-long. Porous implants with similar stiffness to bone can promote bone ingrowth and thus beneficial clinical outcomes. A mechanical remodelling stimulus, strain energy density (SED), is thought to be the primary control variable of the process of bone growth into porous implants. The sequential process of bone growth needs to be taken into account to develop an accurate and validated bone remodelling algorithm, which can be employe
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38

Gao, Xin Rui. "The Design, Rapid Manufacture, and Materials of Artificial Porous Bone Structure." Applied Mechanics and Materials 421 (September 2013): 186–89. http://dx.doi.org/10.4028/www.scientific.net/amm.421.186.

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By using dexelization algorithms, the Brep model of artificial bone is transformed to the three direction DEXEL model and VOXEL model. By setting the transparence attributes of VOXELs in this VOXEL model, the artificial porous bone structures are designed. In order to preserve bio-activities of materials when we manufacture the artificial porous bone structure, the low-temperature deposition manufacturingLDM is used. By using the blended materials poly-lactic-coglycolic acid (PLGA) and tricalcium phosphate (TCP), we could manufacture the artificial porous bone structures.
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Kim, Jung Jae, Hae Jung Kim, and Kang Sik Lee. "Evaluation of Biocompatibility of Porous Hydroxyapatite Developed from Edible Cuttlefish Bone." Key Engineering Materials 361-363 (November 2007): 155–58. http://dx.doi.org/10.4028/www.scientific.net/kem.361-363.155.

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A edible cuttlefish(Zoological name : Sepia esculenta) bone has a porous structure with all pores interconnected The purpose of this research is to develop porous hydroxyapatite prepared by hydrothermal treatment from cuttlefish bone and evaluate the biocompatibility using undecalcified materials through the in-vivo test of rabbits. In this study, the phase and substructure of a porous hydroxyapatite, prepared by hydrothermal treatment using edible cuttlefish bone as a calcium source, has been confirmed by X-ray diffractometer and scanning electronic microscope. After preparing the specimens w
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Zhao, Chao Yong, Hu Li, T. Yuan, Hong Song Fan, Xing Dong Zhang, and Zhong Wei Gu. "A Comparative Study of Porous Titanium with Different Surface Modification Implanted in Dogs." Key Engineering Materials 342-343 (July 2007): 561–64. http://dx.doi.org/10.4028/www.scientific.net/kem.342-343.561.

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This study was carried out to investigate the effect of acid-alkali treatment and alkaliheat treatment on the push-out strength and tissue response of the porous titanium in vivo. Porous titanium with different treatment was implanted in dog bony site for 2 months and 5 months and the push-out strength was tested. At 2 months, the mean push-out strengths of the acid-alkali treated and alkali-heat treated porous titanium were 11.3 and 15 MPa, respectively. At 5 months, the values reached 29.8 and 35 MPa, respectively. Histological observation showed a close contact between implants and bone, an
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Huang, Gan, Shu-Ting Pan, and Jia-Xuan Qiu. "The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering." Materials 14, no. 10 (2021): 2647. http://dx.doi.org/10.3390/ma14102647.

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Porous tantalum (Ta) is a promising biomaterial and has been applied in orthopedics and dentistry for nearly two decades. The high porosity and interconnected pore structure of porous Ta promise fine bone ingrowth and new bone formation within the inner space, which further guarantee rapid osteointegration and bone–implant stability in the long term. Porous Ta has high wettability and surface energy that can facilitate adherence, proliferation and mineralization of osteoblasts. Meanwhile, the low elastic modulus and high friction coefficient of porous Ta allow it to effectively avoid the stres
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42

Supriadi, Sugeng. "Development of Porous Material and Hybrid Porous Ti6Al4V Dental Implants using Metal Injection Molding (MIM)." Journal of Mechanical Engineering 21, no. 1 (2024): 105–22. http://dx.doi.org/10.24191/jmeche.v21i1.25362.

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Dental implants are biomaterial devices implanted in the jawbone through surgery to replace missing teeth. The surface topography of dental implants with surface roughness and a porous layer made of Ti6Al4V material is recommended to improve osseointegration and induce the growth of new bone tissue (bone ingrowth) while reducing the effect of stress shielding due to the high Young's modulus of the implant material. This study presents the fabrication of porous layers, the development of dental implant design, and the manufacturing process of hybrid porous dental implants using Metal Injection
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Wu, Jiongyi, Youwei Zhang, Yongtao Lyu, and Liangliang Cheng. "On the Various Numerical Techniques for the Optimization of Bone Scaffold." Materials 16, no. 3 (2023): 974. http://dx.doi.org/10.3390/ma16030974.

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As the application of bone scaffolds becomes more and more widespread, the requirements for the high performance of bone scaffolds are also increasing. The stiffness and porosity of porous structures can be adjusted as needed, making them good candidates for repairing damaged bone tissues. However, the development of porous bone structures is limited by traditional manufacturing methods. Today, the development of additive manufacturing technology has made it very convenient to manufacture bionic porous bone structures as needed. In the present paper, the current state-of-the-art optimization t
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Wen, Cui E., Yasuo Yamada, A. Nouri, and Peter D. Hodgson. "Porous Titanium with Porosity Gradients for Biomedical Applications." Materials Science Forum 539-543 (March 2007): 720–25. http://dx.doi.org/10.4028/www.scientific.net/msf.539-543.720.

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Highly porous titanium and titanium alloys with an open cell structure are promising implant materials due to their low elastic modulus, excellent bioactivity, biocompatibility and the ability for bone regeneration. However, the mechanical strength of the porous titanium decreases dramatically with increasing porosity, which is a prerequisite for the ingrowth of new bone tissues and vascularization. In the present study, porous titanium with porosity gradients, i.e. solid core with highly porous outer shell was successfully fabricated using a powder metallurgy approach. Satisfactory mechanical
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Will, Julia, Reinhold Melcher, Cornelia Treul, et al. "Porous ceramic bone scaffolds for vascularized bone tissue regeneration." Journal of Materials Science: Materials in Medicine 19, no. 8 (2008): 2781–90. http://dx.doi.org/10.1007/s10856-007-3346-5.

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Goia, Tamiye Simone, Kalan Bastos Violin, José Carlos Bressiani, and Ana Helena de Almeida Bressiani. "Mimicking Bone Architecture in a Metallic Structure." Advances in Science and Technology 84 (September 2012): 7–12. http://dx.doi.org/10.4028/www.scientific.net/ast.84.7.

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The porous metallic structure has been developed to mimic the natural bone architecture, having interconnected porosity, disposing enough room to cell migration, anchoring, vascularization, nourishing and proliferation of new bone tissue. The titanium is used as porous implants due its excellent mechanical properties and biological interaction. Research evolving porous titanium has been done with purpose to achieve desirable pore size, total porosity percentage and influence of those in the increasing of bone-implant bond strength interface. Were prepared samples of titanium by powder metallur
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Zhang, Ye, Jun-Ichiro Jo, Liji Chen, Shigeki Hontsu, and Yoshiya Hashimoto. "Effect of Hydroxyapatite Coating by Er: YAG Pulsed Laser Deposition on the Bone Formation Efficacy by Polycaprolactone Porous Scaffold." International Journal of Molecular Sciences 23, no. 16 (2022): 9048. http://dx.doi.org/10.3390/ijms23169048.

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Composite scaffolds obtained by the combination of biodegradable porous scaffolds and hydroxyapatite with bone regeneration potential are feasible materials for bone tissue engineering. However, most composite scaffolds have been fabricated by complicated procedures or under thermally harsh conditions. We have previously demonstrated that hydroxyapatite coating onto various substrates under a thermally mild condition was achieved by erbium-doped yttrium aluminum garnet (Er: YAG) pulsed laser deposition (PLD). The purpose of this study was to prepare a polycaprolactone (PCL) porous scaffold coa
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Chen, Changjun, Yang Li, Min Zhang, Xiaonan Wang, Chao Zhang, and Hemin Jing. "Effect of laser processing parameters on mechanical properties of porous tantalum fabricated by laser multi-layer micro-cladding." Rapid Prototyping Journal 23, no. 4 (2017): 758–70. http://dx.doi.org/10.1108/rpj-05-2014-0068.

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Purpose Additive manufacturing (AM), a method used in the nuclear, space and racing industries, allows the creation of customized titanium alloy scaffolds with highly defined external shape and internal structure using rapid prototyping as supporting external structures within which bone tissue can grow. AM allows porous tantalum parts with mechanical properties close to that of bone tissue to be obtained. Design/methodology/approach In this paper, porous tantalum structures with different scan distance were fabricated by AM using laser multi-layer micro-cladding. Findings Porous tantalum samp
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Takeuchi, Akari, Chikara Ohtsuki, Masanobu Kamitakahara, et al. "Biodegradation of Porous Alpha-Tricalcium Phosphate Coated with Silk Sericin." Key Engineering Materials 284-286 (April 2005): 329–32. http://dx.doi.org/10.4028/www.scientific.net/kem.284-286.329.

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Porous a-tricalcium phosphate (a-TCP) ceramics are attractive as a novel bioresorbable material for bone repair, since they can be easily fabricated through conventional sintering of b-TCP at high temperature. However, the solubility of a-TCP is too high to keep its body until the bone defect is repaired completely. Coating of the a-TCP porous body with organic polymer is a way to reduce the degradation rate. In the present study, biodegradation of a-TCP porous body coated with silk sericin was evaluated in vivo. Bone repair at the defect made in rabbit tibia was nearly completed after 4 weeks
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Lin, Feng, Cheng Yan, Wei Zheng, Wei Fan, Clayton Adam, and Adekunle Oloyede. "Preparation of Mesoporous Bioglass Coated Zirconia Scaffold for Bone Tissue Engineering." Advanced Materials Research 365 (October 2011): 209–15. http://dx.doi.org/10.4028/www.scientific.net/amr.365.209.

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Porous yttria-stabilized zirconia (YSZ) has been regarded as a potential candidate for bone substitute due to its high mechanical strength. However, porous YSZ is biologically inert to bone tissue. It is therefore necessary to introduce bioactive coatings onto the walls of the porous structures to enhance its bioactivity. In this study, porous YSZ scaffolds were prepared using a replication technique and then coated with mesoporous bioglass due to its excellent bioactivity. The microstructures were examined using scanning electron microscopy and the mechanical strength was evaluated via compre
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