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1

The colours of life: An introduction to the chemistry of porphyrins and related compounds. Oxford: Oxford University Press, 1997.

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2

Sergeevich, Enikolopi͡a︡n Nikolaĭ, ed. Metalloporfiriny. Moskva: "Nauka", 1988.

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3

Berezin, Dmitrij Borisovič. Makrocikličeskij ėffekt i strukturnaja chimija porfirinov. Moskva: URSS [u.a.], 2010.

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4

Brady, Sharon P. Porphyrins and metalloporphyrins as biomimetic oxidation catalysts and as photosensitisers in photodynamic therapy. Dublin: University College Dublin, 1997.

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5

Singh, Jag J. Investigation of oxygen-induced quenching of phosphorescence in photoexcited aromatic molecules by positron annihilation spectroscopy. Hampton, Va: National Aeronautics and Space Administration, Langley Research Center, 1996.

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6

Singh, Jag J. Investigation of oxygen-induced quenching of phosphorescence in photoexcited aromatic molecules by positron annihilation spectroscopy. Hampton, Va: National Aeronautics and Space Administration, Langley Research Center, 1996.

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7

Singh, Jag J. Investigation of oxygen-induced quenching of phosphorescence in photoexcited aromatic molecules by positron annihilation spectroscopy. Hampton, Va: National Aeronautics and Space Administration, Langley Research Center, 1996.

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8

Singh, Jag J. Investigation of oxygen-induced quenching of phosphorescence in photoexcited aromatic molecules by positron annihilation spectroscopy. Hampton, Va: National Aeronautics and Space Administration, Langley Research Center, 1996.

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9

Singh, Jag J. Investigation of oxygen-induced quenching of phosphorescence in photoexcited aromatic molecules by positron annihilation spectroscopy. Hampton, Va: National Aeronautics and Space Administration, Langley Research Center, 1996.

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10

Photosensitizers in medicine, environment, and security. Dordrecht: Springer, 2012.

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11

A, Sheldon Roger, ed. Metalloporphyrins in catalyticoxidations. New York: M. Dekker, 1994.

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12

A, Sheldon Roger, ed. Metalloporphyrins in catalytic oxidations. New York: M. Dekker, 1994.

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13

Weber, E. Topics in Current Chemistry: Macrocycles (Topics in Current Chemistry). Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, 1991.

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14

Kessel, David, Thomas J. Dougherty, Donald Pfaff, and Ravindra K. Pandey. Handbook of Photodynamic Therapy: Updates on Recent Applications of Porphyrin-Based Compounds. World Scientific Publishing Co Pte Ltd, 2016.

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15

Dierdorf, Stephen F. Porphyria. Edited by Matthew D. McEvoy and Cory M. Furse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190226459.003.0026.

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Heme, and iron containing compound that forms the nonprotein portion of hemoglobin, is essential to life. Heme synthesis requires eight enzymatic steps, and a deficiency in any one of the eight enzymes can lead to the accumulation of potentially toxic intermediates. Some forms of porphyria may be asymptomatic until the patient receives a triggering agent, and acute porphyrias can also be difficult to diagnose because of the nonspecific clinical features. The most serious of the clinical manifestations is severe neurologic dysfunction. An attack can be triggered by medications administered during the perioperative period, and failure to act promptly can result in mortality rates as high as 5%.
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16

K, Silbergeld Ellen, Fowler Bruce A, and New York Academy of Sciences., eds. Mechanisms of chemical-induced porphyrinopathies. New York, N.Y: New York Academy of Sciences, 1987.

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17

Deegan, Patrick. Porphyria. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0179.

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This chapter discusses six diseases caused by inborn errors of metabolism affecting the biosynthesis of haem. Haem is a tetracyclic metal-binding compound involved in oxygen transport (in haemoglobin and myoglobin) and redox reactions (e.g. in the cytochrome P450 system). Each of these conditions is caused by a single gene defect in one of the enzymes involved in the biosynthesis of haem. Inheritance is usually autosomal dominant with incomplete penetrance. The enzyme defect results in disease, not as a result of deficiency of the reaction product, but as a result of accumulation of precursors. Early, soluble precursors, 5-aminolaevulinic acid, and porphobilinogen (not porphyrins as such) are neurotoxic and, when present in great excess, as occurs when flux through the haem synthetic pathway is increased in response to particular medications or hormones, lead to acute neurovisceral crises. Later cyclical precursors (porphyrins) in the pathway are also water soluble and excreted in urine, but are susceptible to activation by electromagnetic radiation in the visible spectrum and are converted to free-radical metabolites that cause pain, inflammation, and tissue damage in the skin. The final haem precursors (also porphyrins) are hydrophobic and excreted in the bile and faeces and are also activated by light to toxic metabolites.
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18

Lee, Y. J. Metal Complexes with Tetrapyrrole Ligands I. Springer, 2013.

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19

Porphyrins and Related Compounds - Properties and Applications [Working Title]. IntechOpen, 2019. http://dx.doi.org/10.5772/intechopen.80112.

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20

W, Buchler J., ed. Metal complexes with Tetrapyrrole Ligands III. Berlin: Springer, 1995.

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21

Nyokong, Tebello, and Vefa Ahsen. Photosensitizers in Medicine, Environment, and Security. Springer, 2014.

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22

Nyokong, Tebello, and Vefa Ahsen. Photosensitizers in Medicine, Environment, and Security. Springer, 2012.

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23

N, Lomova T., and Zaikov Gennadiĭ Efremovich, eds. Chemical processes with participation of biological and related compounds: Biophysical and chemical aspects of porphyrins, pigments, drugs, biodegradable polymers and nanofibers. Leiden: Brill, 2008.

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24

N, Lomova T., and Zaikov Gennadiĭ Efremovich, eds. Chemical processes with participation of biological and related compounds: Biophysical and chemical aspects of porphyrins, pigments, drugs, biodegradable polymers and nanofibers. Leiden: Brill, 2008.

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