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Journal articles on the topic 'Porphyromonas gingivalis infections'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Winkelhoff, Arie J., and Jørgen Slots. "Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in nonoral infections." Periodontology 2000 20, no. 1 (June 1999): 122–35. http://dx.doi.org/10.1111/j.1600-0757.1999.tb00160.x.

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Condorelli, Francesca, Guido Scalia, Giuditta Calì, Bruno Rossetti, Giuseppe Nicoletti, and Anna M. Lo Bue. "Isolation of Porphyromonas gingivalisand Detection of Immunoglobulin A Specific to Fimbrial Antigen in Gingival Crevicular Fluid." Journal of Clinical Microbiology 36, no. 8 (1998): 2322–25. http://dx.doi.org/10.1128/jcm.36.8.2322-2325.1998.

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The present study evaluated the prevalence of Porphyromonas gingivalis and the correlation between the bacterial culture method and the detection of immunoglobulin A (IgA) specific to theP. gingivalis fimbrial antigen in gingival crevicular fluid (GCF). P. gingivalis was isolated from 78.3% of subgingival plaque samples obtained from active sites and 34.7% of those from inactive sites of periodontal patients. P. gingivalis was isolated from only 4.7% of healthy subjects (control group). Immunoglobulins specific to the P. gingivalis fimbrial antigen were detected by enzyme-linked immunosorbent

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3

Hirasawa, Masaaki, and Tomoko Kurita-Ochiai. "Porphyromonas gingivalis Induces Apoptosis and Autophagy via ER Stress in Human Umbilical Vein Endothelial Cells." Mediators of Inflammation 2018 (July 29, 2018): 1–8. http://dx.doi.org/10.1155/2018/1967506.

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It has been reported that periodontitis is associated with an increased risk of atherosclerosis. Accumulating evidence suggests that endothelial dysfunction is an early marker for atherosclerosis. To determine how periodontal infections contribute to endothelial dysfunction, we examined the effect of Porphyromonas gingivalis on human umbilical vein endothelial cells (HUVEC). P. gingivalis significantly suppressed the viability of HUVEC, induced DNA fragmentation and annexin V staining, and increased caspase-3, caspase-8, and caspase-9 activities. P. gingivalis also increased the expression of

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4

Wu, Jie, and Hua Xie. "Role of Arginine Deiminase of Streptococcus cristatus in Porphyromonas gingivalis Colonization." Antimicrobial Agents and Chemotherapy 54, no. 11 (July 26, 2010): 4694–98. http://dx.doi.org/10.1128/aac.00284-10.

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ABSTRACT The ability to attach to a variety of oral surfaces is an important characteristic of Porphyromonas gingivalis. Previous studies have demonstrated that expression and production of FimA, a major subunit protein of the long fimbriae, is required for P. gingivalis colonization. Here we report that a surface protein, arginine deiminase (ArcA) of Streptococcus cristatus, represses FimA production and inhibits biofilm formation of P. gingivalis. This inhibitory function of ArcA is also observed in the formation of heterotypic P. gingivalis-Streptococcus gordonii biofilms. P. gingivalis is

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Rôças, Isabela N., and José F. Siqueira. "Distribution of Porphyromonas gingivalis fimA genotypes in primary endodontic infections." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 109, no. 3 (March 2010): 474–78. http://dx.doi.org/10.1016/j.tripleo.2009.11.009.

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6

Odell, Lynnetta J., J. Craig Baumgartner, Tian Xia, and Larry L. David. "Survey for collagenase gene prtC in Porphyromonas gingivalis and Porphyromonas endodontalis isolated from endodontic infections." Journal of Endodontics 25, no. 8 (August 1999): 555–58. http://dx.doi.org/10.1016/s0099-2399(99)80379-3.

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7

Fiorillo, Luca, Gabriele Cervino, Luigi Laino, Cesare D’Amico, Rodolfo Mauceri, Tolga Fikret Tozum, Michele Gaeta, and Marco Cicciù. "Porphyromonas gingivalis, Periodontal and Systemic Implications: A Systematic Review." Dentistry Journal 7, no. 4 (December 11, 2019): 114. http://dx.doi.org/10.3390/dj7040114.

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In recent scientific literature, oral infections and systemic manifestations, or correlations between oral health and systemic diseases are a topic of discussion. Porphyromonas gingivalis is one of the bacteria implicated in the biofilm formation of bacterial plaque, and plays an important role in the progression of periodontal disease. In this systematic review authors have evaluated the literature of the last 10 years on P. gingivalis and all the systemic implications proven. This study therefore evaluates all the districts of the organism in which this bacterium may have implications. From

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8

Maezono, H., Y. Noiri, Y. Asahi, M. Yamaguchi, R. Yamamoto, N. Izutani, H. Azakami, and S. Ebisu. "Antibiofilm Effects of Azithromycin and Erythromycin on Porphyromonas gingivalis." Antimicrobial Agents and Chemotherapy 55, no. 12 (September 12, 2011): 5887–92. http://dx.doi.org/10.1128/aac.05169-11.

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ABSTRACTAntibiotic resistance of biofilm-grown bacteria contributes to chronic infections, such as marginal and periapical periodontitis, which are strongly associated withPorphyromonas gingivalis. Concurrent azithromycin (AZM) administration and mechanical debridement improve the clinical parameters of periodontal tissuein situ. We examined thein vitroefficacy of AZM againstP. gingivalisbiofilms. The susceptibilities of adherentP. gingivalisstrains 381, HW24D1, 6/26, and W83 to AZM, erythromycin (ERY), ampicillin (AMP), ofloxacin (OFX), and gentamicin (GEN) were investigated using a static mo

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9

Siqueira, José F., Isabela N. Rôças, and Marlei G. Silva. "Prevalence and Clonal Analysis of Porphyromonas gingivalis in Primary Endodontic Infections." Journal of Endodontics 34, no. 11 (November 2008): 1332–36. http://dx.doi.org/10.1016/j.joen.2008.08.021.

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10

Loos, B. G., D. Mayrand, R. J. Genco, and D. P. Dickinson. "Genetic Heterogeneity of Porphyromonas (Bacteroides) gingivalis by Genomic DNA Fingerprinting." Journal of Dental Research 69, no. 8 (August 1990): 1488–93. http://dx.doi.org/10.1177/00220345900690080801.

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This study describes the use of total genomic DNA fingerprinting with the use of restriction endonucleases to characterize clinical isolates of Porphyromonas gingivalis (Bacteroides gingivalis) obtained from patients with periodontitis or with root-canal infections. The majority of independent isolates had a unique DNA fingerprint, indicating extensive genetic heterogeneity within this species. Twenty-nine distinct DNA fingerprints were found among the 33 isolates investigated. This is in contrast to biotyping and serotyping, where only one type and three types, respectively, have been reporte

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11

Pyrc, Krzysztof, Paulina Strzyz, Aleksandra Milewska, Anna Golda, Oliver Schildgen, and Jan Potempa. "Porphyromonas gingivalis enzymes enhance infection with human metapneumovirus in vitro." Journal of General Virology 92, no. 10 (October 1, 2011): 2324–32. http://dx.doi.org/10.1099/vir.0.032094-0.

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Relatively recently discovered, human metapneumovirus (HMPV) is a human pathogen with worldwide prevalence, accounting for a substantial percentage of respiratory tract diseases. Concurrent viral and bacterial infections enable intricate mechanisms of cooperation between pathogens, which complicate the symptoms and outcome of the disease. Such bilateral interactions are based on the modulation of bacterial growth on epithelium pathologically altered during viral illness and the modulation of immune responses, as well as the enhancement of virus replication by bacterial virulence factors. This

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12

Cao, H., Z. Qi, H. Jiang, J. Zhao, Z. Liu, and Z. Tang. "Detection of Porphyromonas endodontalis, Porphyromonas gingivalis and Prevotella intermedia in primary endodontic infections in a Chinese population." International Endodontic Journal 45, no. 8 (March 19, 2012): 773–81. http://dx.doi.org/10.1111/j.1365-2591.2012.02035.x.

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13

Jacinto, R. C., B. P. F. A. Gomes, H. N. Shah, C. C. Ferraz, A. A. Zaia, and F. J. Souza-Filho. "Incidence and antimicrobial susceptibility of Porphyromonas gingivalis isolated from mixed endodontic infections." International Endodontic Journal 39, no. 1 (January 3, 2006): 62–70. http://dx.doi.org/10.1111/j.1365-2591.2005.01053.x.

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14

Kesavalu, Lakshmyya, Sabapathi Sathishkumar, Vasudevan Bakthavatchalu, Chad Matthews, Dolph Dawson, Michelle Steffen, and Jeffrey L. Ebersole. "Rat Model of Polymicrobial Infection, Immunity, and Alveolar Bone Resorption in Periodontal Disease." Infection and Immunity 75, no. 4 (January 8, 2007): 1704–12. http://dx.doi.org/10.1128/iai.00733-06.

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ABSTRACT One of the predominant polymicrobial infections of humans is expressed clinically as periodontal disease. Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia have been strongly implicated as members of a pathogenic consortium in the etiology of adult periodontitis. In this study we hypothesized that P. gingivalis, T. denticola, and T. forsythia are synergistic in terms of virulence potential and induce chronic periodontal inflammation that leads to alveolar bone resorption in a polymicrobial infection in rats. Groups of rats were infected with either P. gingivalis,

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Zhang, Ping, Jianzhong Liu, Qingan Xu, Gregory Harber, Xu Feng, Suzanne M. Michalek та Jenny Katz. "TLR2-dependent Modulation of Osteoclastogenesis by Porphyromonas gingivalis through Differential Induction of NFATc1 and NF-κB". Journal of Biological Chemistry 286, № 27 (12 травня 2011): 24159–69. http://dx.doi.org/10.1074/jbc.m110.198085.

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Osteolytic diseases, including rheumatoid arthritis, osteomyelitis, and periodontitis, are usually associated with bacterial infections. However, the precise mechanisms by which bacteria induce bone loss still remain unclear. Evidence exists that Toll-like receptor (TLR) signaling regulates both inflammation and bone metabolism and that the receptor activator of NF-κB ligand (RANKL) and its receptor RANK are the key regulators for bone remodeling and for the activation of osteoclasts. Here, we investigate the direct effects of the periodontal pathogen Porphyromonas gingivalis on osteoclast dif

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16

Teng, Y. T. A. "Protective and Destructive Immunity in the Periodontium: Part 1—Innate and Humoral Immunity and the Periodontium." Journal of Dental Research 85, no. 3 (March 2006): 198–208. http://dx.doi.org/10.1177/154405910608500301.

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Based on the results of recent research in the field, the present paper will discuss the protective and destructive aspects of the innate vs. adaptive (humoral and cell-mediated) immunity associated with the bacterial virulent factors or antigenic determinants during periodontal pathogenesis. Attention will be focused on: (i) the Toll-like receptors (TLR), the innate immune repertoire for recognizing the unique molecular patterns of microbial components that trigger innate and adaptive immunity for effective host defenses, in some general non-oral vs. periodontal microbial infections; (ii) T-c

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17

Allaker, R. P., K. A. Young, T. Langlois, R. de Rosayro, and J. M. Hardie. "Dental Plaque Flora of the Dog with Reference to Fastidious and Anaerobic Bacteria Associated with Bites." Journal of Veterinary Dentistry 14, no. 4 (December 1997): 127–30. http://dx.doi.org/10.1177/089875649701400401.

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Animal bite wounds are amongst the most common types of traumatic injuries in humans. The organisms isolated from these wounds generally reflect the oral flora of the biting animal and may be fastidious in nature and difficult to identify. This study was undertaken to determine the prevalence of Eikenella corrodens, Actinobacillus actinomycetemcomitans, Porphyromonas and Prevotella spp. in supragingival dental plaque collected from the right maxillary canine and carnassial teeth and the right mandibular canine tooth of dogs. In part one of the study, 30 dogs were used. E. corrodens was found i

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18

Lopatin, Dennis E., Allison Combs, Domenica G. Sweier, J. Christopher Fenno, and Sangeeta Dhamija. "Characterization of Heat-Inducible Expression and Cloning of HtpG (Hsp90 Homologue) of Porphyromonas gingivalis." Infection and Immunity 68, no. 4 (April 1, 2000): 1980–87. http://dx.doi.org/10.1128/iai.68.4.1980-1987.2000.

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ABSTRACT Porphyromonas gingivalis is implicated in the etiology of periodontal disease. Associations between microbial virulence and stress protein expression have been identified in other infections. For example, Hsp90 homologues in several microbial species have been shown to contribute to virulence. We previously reported that P. gingivalis possessed an Hsp90 homologue (HtpG) which cross-reacts with human Hsp90. In addition, we found that elevated levels of serum antibody to Hsp90 stress protein in individuals colonized with this microorganism were associated with periodontal health. Howeve

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19

Núñez-Acurio, Daniela, Denisse Bravo, and Francisco Aguayo. "Epstein–Barr Virus—Oral Bacterial Link in the Development of Oral Squamous Cell Carcinoma." Pathogens 9, no. 12 (December 18, 2020): 1059. http://dx.doi.org/10.3390/pathogens9121059.

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Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer. Its development has been associated with diverse factors such as tobacco smoking and alcohol consumption. In addition, it has been suggested that microorganisms are risk factors for oral carcinogenesis. Epstein–Barr virus (EBV), which establishes lifelong persistent infections and is intermittently shed in the saliva, has been associated with several lymphomas and carcinomas that arise in the oral cavity. In particular, it has been detected in a subset of OSCCs. Moreover, its presence in patients with periodontitis has

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20

Inagaki, Satoru, Shinsuke Onishi, Howard K. Kuramitsu, and Ashu Sharma. "Porphyromonas gingivalis Vesicles Enhance Attachment, and the Leucine-Rich Repeat BspA Protein Is Required for Invasion of Epithelial Cells by “Tannerella forsythia”." Infection and Immunity 74, no. 9 (September 2006): 5023–28. http://dx.doi.org/10.1128/iai.00062-06.

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ABSTRACTThe human oral cavity harbors more than 500 species of bacteria. Periodontitis, a bacterially induced inflammatory disease that leads to tooth loss, is believed to result from infection by a select group of gram-negative periodontopathogens that includesPorphyromonas gingivalis,Treponema denticola, and “Tannerella forsythia” (opinion on name change fromTannerella forsythensispending; formerlyBacteroides forsythus). Epithelial cell invasion by periodontopathogens is considered to be an important virulence mechanism for evasion of the host defense responses. Further, the epithelial cells

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21

Socransky, Sigmund S., Anne D. Haffajee, Laurie Ann Ximenez-Fyvie, Magda Feres, and Donna Mager. "Ecological considerations in the treatment of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis periodontal infections." Periodontology 2000 20, no. 1 (June 1999): 341–62. http://dx.doi.org/10.1111/j.1600-0757.1999.tb00165.x.

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22

Wikström, M., J. L. Wennstrom, S. Renvert, and R. Jonsson. "Immunohistological characteristics of periodontal lesions associated with Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans infections." Oral Microbiology and Immunology 11, no. 1 (February 1996): 1–7. http://dx.doi.org/10.1111/j.1399-302x.1996.tb00329.x.

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23

Alshammari, Hatem, Jessica Neilands, Gunnel Svensäter, and Andreas Stavropoulos. "Antimicrobial Potential of Strontium Hydroxide on Bacteria Associated with Peri-Implantitis." Antibiotics 10, no. 2 (February 3, 2021): 150. http://dx.doi.org/10.3390/antibiotics10020150.

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Background: Peri-implantitis due to infection of dental implants is a common complication that may cause significant patient morbidity. In this study, we investigated the antimicrobial potential of Sr(OH)2 against different bacteria associated with peri-implantitis. Methods: The antimicrobial potential of five concentrations of Sr(OH)2 (100, 10, 1, 0.1, and 0.01 mM) was assessed with agar diffusion test, minimal inhibitory concentration (MIC), and biofilm viability assays against six bacteria commonly associated with biomaterial infections: Streptococcus mitis, Staphylococcus epidermidis, Aggr

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Kalburgi, Nagaraj B., Arati C. Koregol, Ruchita S. Patil, and Tejashwini Puttarevanna. "ANTI-MICROBIAL EFFICACY OF AN ETHANOLIC EXTRACT OF MURRAYA KOENIGII AGAINST PERIODONTAL PATHOGENS LIKE PORPHYROMONAS GINGIVALIS AND AGGREGATIBACTER ACTINOMYCETEMCOMITANS: IN VITRO ANALYSIS." International Journal of Research in Ayurveda and Pharmacy 12, no. 3 (July 6, 2021): 41–45. http://dx.doi.org/10.7897/2277-4343.120371.

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Periodontitis is primarily an infectious disease with Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans present in plaque biofilm as the key pathogens, causing destruction of supporting periodontal tissues. Herbal formulations are widely substituting synthetic anti-microbials due to their minimal adverse effects and cost effectiveness. Murraya koenigii (M. koenigii) is a well-known anti-microbial agent used in treating systemic infections. Hence its anti-microbial efficacy against key periodontal pathogens also needs to be tested. The aim of this study is to determine Minimum

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Zhu, Hongguang, Shouyi Lu, Meirong Wei, Xiaoshan Cai, and Guoyou Wang. "Identification of novel genes involved in gingival epithelial cells responding to Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis infections." Archives of Oral Biology 96 (December 2018): 113–21. http://dx.doi.org/10.1016/j.archoralbio.2018.08.017.

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Curtis, M. A., J. Aduse Opoku, M. Rangarajan, A. Gallagher, J. A. C. Sterne, C. R. Reid, H. E. A. Evans, and B. Samuelsson. "Attenuation of the Virulence of Porphyromonas gingivalis by Using a Specific Synthetic Kgp Protease Inhibitor." Infection and Immunity 70, no. 12 (December 2002): 6968–75. http://dx.doi.org/10.1128/iai.70.12.6968-6975.2002.

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ABSTRACT The Arg- and Lys-gingipains of Porphyromonas gingivalis are important virulence determinants in periodontal disease and may correspond to targets for immune- or drug-based treatment strategies. In this investigation we aimed to determine which of these enzymes represents the most promising molecular target for protease inhibitor-based therapy and to examine the effectiveness of the resultant compound in a murine virulence assay. Isogenic mutants with mutations in rgpA and rgpB (encoding Arg-gingipains) and in kgp (encoding Lys-gingipain) and a double mutant with mutations in rgpA and

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27

Guthmiller, Janet M., Kaaren G. Vargas, Rupasree Srikantha, Lori L. Schomberg, Paula L. Weistroffer, Paul B. McCray, and Brian F. Tack. "Susceptibilities of Oral Bacteria and Yeast to Mammalian Cathelicidins." Antimicrobial Agents and Chemotherapy 45, no. 11 (November 1, 2001): 3216–19. http://dx.doi.org/10.1128/aac.45.11.3216-3219.2001.

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ABSTRACT The effects of cathelicidins against oral bacteria and clinically important oral yeasts are not known. We tested the susceptibilities of Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum,Porphyromonas gingivalis, Streptococcus sanguis, Candida krusei, Candida tropicalis and Candida albicans to the following cathelicidins: FALL39, SMAP29, and CAP18. SMAP29 and CAP18 were antimicrobial, whereas FALL39 did not exhibit antimicrobial activity. Future studies are needed to determine the potential use of these antimicrobial peptides in prevention and treatment of oral infections.

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Kulik, Eva M., Thomas Thurnheer, Lamprini Karygianni, Clemens Walter, Anton Sculean, and Sigrun Eick. "Antibiotic Susceptibility Patterns of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis Strains from Different Decades." Antibiotics 8, no. 4 (December 6, 2019): 253. http://dx.doi.org/10.3390/antibiotics8040253.

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The aim of this study was to determine the antibiotic susceptibility patterns of 57 Aggregatibacter actinomycetemcomitans and 56 Porphyromonas gingivalis strains isolated from subgingival biofilm samples of periodontitis patients in Switzerland from 1980 to 2017. The minimal inhibitory concentrations (MIC) of the most commonly used antibiotics in periodontal therapy (amoxicillin, metronidazole, azithromycin, and doxycycline) or in severe body infections (amoxicillin/clavulanic acid, clindamycin, ertapenem, and moxifloxacin) were determined. Furthermore, all the strains were screened for beta-l

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Ślęzak, Paulina, Michał Śmiga, John W. Smalley, Klaudia Siemińska, and Teresa Olczak. "Porphyromonas gingivalis HmuY and Streptococcus gordonii GAPDH—Novel Heme Acquisition Strategy in the Oral Microbiome." International Journal of Molecular Sciences 21, no. 11 (June 10, 2020): 4150. http://dx.doi.org/10.3390/ijms21114150.

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The oral cavity of healthy individuals is inhabited by commensals, with species of Streptococcus being the most abundant and prevalent in sites not affected by periodontal diseases. The development of chronic periodontitis is linked with the environmental shift in the oral microbiome, leading to the domination of periodontopathogens. Structure-function studies showed that Streptococcus gordonii employs a “moonlighting” protein glyceraldehyde-3-phosphate dehydrogenase (SgGAPDH) to bind heme, thus forming a heme reservoir for exchange with other proteins. Secreted or surface-associated SgGAPDH c

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Brzezińska-Błaszczyk, Ewa, Elżbieta Pawłowska, Tomasz Płoszaj, Henryk Witas, Urszula Godzik, and Justyna Agier. "Presence of archaea and selected bacteria in infected root canal systems." Canadian Journal of Microbiology 64, no. 5 (May 2018): 317–26. http://dx.doi.org/10.1139/cjm-2017-0531.

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Infections of the root canal have polymicrobial etiology. The main group of microflora in the infected pulp is bacteria. There is limited data that archaea may be present in infected pulp tissue. The aim of this study was to check the prevalence of archaea in necrotic root canal samples obtained from patients with primary or post-treatment infection. The prevalence of selected bacteria species (Prevotella intermedia, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Synergistes sp.) in necrotic samples was evaluated as well. Sixty-four samples from root canal were collected

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Lewis, Janina P., and Francis L. Macrina. "IS195, an Insertion Sequence-Like Element Associated with Protease Genes in Porphyromonas gingivalis." Infection and Immunity 66, no. 7 (July 1, 1998): 3035–42. http://dx.doi.org/10.1128/iai.66.7.3035-3042.1998.

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ABSTRACT Porphyromonas gingivalis is recognized as an important etiologic agent in adult and early-onset periodontal disease. Proteases produced by this organism contribute to its virulence in mice. Protease-encoding genes have been shown to contain multiple copies of repeated nucleotide sequences. These conserved sequences have also been found in hemagglutinin genes. In the process of studying the genetic loci containing the conserved repeated sequences, we have characterized a prtP gene homolog from P. gingivalis W83 encoding a cysteine protease with Lys-X specificity. However, thisprtP gene

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M. M. Al-Rawi, Amera. "Detection of Porphyromonas gingivalis from Periodontal Pocket Infections by Microbial Cultivation and PCR Techniques." Rafidain Journal of Science 23, no. 2 (March 1, 2012): 39–55. http://dx.doi.org/10.33899/rjs.2012.27971.

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Yu, Wen-Han, Han Hu, Qingde Zhou, Yu Xia, and Salomon Amar. "Bioinformatics Analysis of Macrophages Exposed to Porphyromonas gingivalis: Implications in Acute vs. Chronic Infections." PLoS ONE 5, no. 12 (December 23, 2010): e15613. http://dx.doi.org/10.1371/journal.pone.0015613.

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Loos, B. G., D. W. Dyer, T. S. Whittam, and R. K. Selander. "Genetic structure of populations of Porphyromonas gingivalis associated with periodontitis and other oral infections." Infection and Immunity 61, no. 1 (1993): 204–12. http://dx.doi.org/10.1128/iai.61.1.204-212.1993.

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Ramalingam, Ashwin Kumar, Smiline Girija Aseervatham Selvi, and Vijayashree Priyadharsini Jayaseelan. "Targeting prolyl tripeptidyl peptidase from Porphyromonas gingivalis with the bioactive compounds from Rosmarinus officinalis." Asian Biomedicine 13, no. 5 (June 4, 2020): 197–203. http://dx.doi.org/10.1515/abm-2019-0061.

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AbstractBackgroundComplications in periodontitis and other systemic infections related to Porphyromonas gingivalis poses a serious impediment in the treatment process. This leads to the search of novel target proteins to develop newer drugs against P. gingivalis. Prolyl tripeptidyl peptidase (ptp-A) seem to be a vital protein in P. gingivalis virulence and can be a good target for the novel natural bioactive compounds.ObjectivesTo explore the inhibitory potential of Rosmarinus officinalis biocompounds against the ptp-A of P. gingivalis.MethodsThree-dimensional structure of ptp-A was retrieved

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Fani, Mohammadmehdi, and Jamshid Kohanteb. "In Vitro Antimicrobial Activity of Thymus vulgaris Essential Oil Against Major Oral Pathogens." Journal of Evidence-Based Complementary & Alternative Medicine 22, no. 4 (April 11, 2017): 660–66. http://dx.doi.org/10.1177/2156587217700772.

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The objective of present investigation was to determine antimicrobial activity of Thymus vulgaris oil on some oral pathogens. Thymus vulgaris oil was prepared by hydrodistillation and tested against 30 clinical isolates of each of Streptococcus pyogenes, Streptococcus mutans, Candida albicans, Porphyromonas gingivalis, and Aggregatibacter actinomycetemcomitans, prepared from related oral infections using agar disk diffusion and broth microdilution methods. Thymus vulgaris oil at concentrations of 16 to 256 μg/mL exhibited strong inhibitory activity on all clinical isolates producing inhibition

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GOMES, B., F. MONTAGNER, R. JACINTO, A. ZAIA, C. FERRAZ, and F. SOUZAFILHO. "Polymerase Chain Reaction of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia in Primary Endodontic Infections." Journal of Endodontics 33, no. 9 (September 2007): 1049–52. http://dx.doi.org/10.1016/j.joen.2007.05.017.

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Mättö, J., S. Asikainen, M. ‐L Väisänen, M. Rautio, M. Saarela, P. Summanen, S. Finegold, and H. Jousimies‐Somer. "Role of Porphyromonas gingivalis, Prevotella intermedia, and Prevotella nigrescens in Extraoral and Some Odontogenic Infections." Clinical Infectious Diseases 25, s2 (September 1997): S194—S198. http://dx.doi.org/10.1086/516205.

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Rôças, Isabela N., José F. Siqueira, Kátia R. N. Santos, Ana M. A. Coelho, and Rio de Janeiro. "“Red complex” (Bacteroides forsythus, Porphyromonas gingivalis, and Treponema denticola ) in endodontic infections: A molecular approach." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 91, no. 4 (April 2001): 468–71. http://dx.doi.org/10.1067/moe.2001.114379.

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Zhao, Xue, Peng Wan, Hongyan Wang, Shuwei Zhang, Jingbo Liu, Chunrong Chang, Ke Yang, and Yaping Pan. "An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics." BioMed Research International 2020 (August 28, 2020): 1–9. http://dx.doi.org/10.1155/2020/7289208.

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Periodontal diseases are mainly the results of infections and inflammation of the gum and bone that surround and support the teeth. In this study, the alveolar bone destruction in periodontitis is hypothesized to be treated with novel Mg-Cu alloy grafts due to their antimicrobial and osteopromotive properties. In order to study this new strategy using Mg-Cu alloy grafts as a periodontal bone substitute, the in vitro degradation and antibacterial performance were examined. The pH variation and Mg2+ and Cu2+ release of Mg-Cu alloy extracts were measured. Porphyromonas gingivalis (P. gingivalis)

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Foschi, F., J. Izard, H. Sasaki, V. Sambri, C. Prati, R. Müller, and P. Stashenko. "Treponema denticola in Disseminating Endodontic Infections." Journal of Dental Research 85, no. 8 (August 2006): 761–65. http://dx.doi.org/10.1177/154405910608500814.

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Treponema denticola is a consensus periodontal pathogen that has recently been associated with endodontic pathology. In this study, the effect of mono-infection of the dental pulp with T. denticola and with polymicrobial "red-complex" organisms (RC) ( Porphyromonas gingivalis, Tannerella forsythia, and T. denticola) in inducing disseminating infections in wild-type (WT) and severe-combined-immunodeficiency (SCID) mice was analyzed. After 21 days, a high incidence (5/10) of orofacial abscesses was observed in SCID mice mono-infected with T. denticola, whereas abscesses were rare in SCID mice in

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Nibali, L., D. R. Ready, M. Parkar, P. M. Brett, M. Wilson, M. S. Tonetti, and G. S. Griffiths. "Gene Polymorphisms and the Prevalence of Key Periodontal Pathogens." Journal of Dental Research 86, no. 5 (May 2007): 416–20. http://dx.doi.org/10.1177/154405910708600505.

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Growing evidence suggests that individual genetic susceptibility may influence the host’s response to infections. The aim of this project was to study whether gene polymorphisms of inflammatory markers are associated with the presence of viable periodontopathogenic bacteria. We extracted genomic DNA from 45 young adults diagnosed with generalized aggressive periodontitis to study Fc receptors, formyl peptide receptor, Interleukin-6, tumor necrosis factor-α, and vitamin D receptor polymorphisms. The presence and viable numbers of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, a

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Amorim, Crystiane Venditi Gomes do, Carlos Eduardo Aun, and Marcia Pinto Alves Mayer. "Susceptibility of some oral microorganisms to chlorhexidine and paramonochlorophenol." Brazilian Oral Research 18, no. 3 (September 2004): 242–46. http://dx.doi.org/10.1590/s1806-83242004000300012.

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Since the use of antimicrobial agents is required in endodontic therapies, this study aimed at determining the minimum inhibitory concentrations (MICs) of chlorhexidine digluconate and paramonochlorophenol (PMC) against microorganisms commonly found in endodontic infections. Both agents were tested by agar dilution tests against Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Candida albicans, Prevotella intermedia, Porphyromonas gingivalis, Porphyromonas endodontalis, Prevotella denticola and Prevotella melaninogenica. The MIC of chlorhexidine ranged fr

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O’Connor, Andrew, and Siobhán McClean. "The Role of Universal Stress Proteins in Bacterial Infections." Current Medicinal Chemistry 24, no. 36 (November 24, 2017): 3970–79. http://dx.doi.org/10.2174/0929867324666170124145543.

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Universal stress proteins are ubiquitously expressed in bacteria, archaea and plants and other eukaryotes. A general property of USPs is their role in adaptation of bacteria to oxidative stress, high temperature, low pH and/or hypoxia. There is increasing evidence that these proteins facilitate the adaption of bacterial pathogens to the human host environment, thereby facilitating colonisation and pathogenicity. USPs in Mycobacterium tuberculosis are well studied and may play a role in latency of tuberculosis. USP expressed by Acinetobacter baumannii, Listeria monocytogenes and Salmonella ente

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Saito, Daniel, Luiz Lehmann Coutinho, Cristiane Pereira Borges Saito, Siu Mui Tsai, José Francisco Höfling, and Reginaldo Bruno Gonçalves. "Real-time Polymerase Chain Reaction Quantification of Porphyromonas gingivalis and Tannerella forsythia in Primary Endodontic Infections." Journal of Endodontics 35, no. 11 (November 2009): 1518–24. http://dx.doi.org/10.1016/j.joen.2009.08.005.

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Love, Robert M., Malcolm D. McMillan, Yoonsuk Park, and Howard F. Jenkinson. "Coinvasion of Dentinal Tubules byPorphyromonas gingivalis and Streptococcus gordonii Depends upon Binding Specificity of Streptococcal Antigen I/II Adhesin." Infection and Immunity 68, no. 3 (March 1, 2000): 1359–65. http://dx.doi.org/10.1128/iai.68.3.1359-1365.2000.

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ABSTRACT Cell wall-anchored polypeptides of the antigen I/II family are produced by many species of oral streptococci. These proteins mediate adhesion of streptococci to salivary glycoproteins and to other oral microorganisms and promote binding of cells to collagen type I and invasion of dentinal tubules. Since infections of the root canal system have a mixed anaerobic bacterial etiology, we investigated the hypothesis that coadhesion of anaerobic bacteria with streptococci may facilitate invasive endodontic disease. Porphyromonas gingivalis ATCC 33277 cells were able to invade dentinal tubul

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Lisbona-González, Maria Jesús, Esther Muñoz-Soto, Candela Reyes-Botella, Maria Victoria Olmedo-Gaya, Javier Diaz-Castro, and Jorge Moreno-Fernandez. "Study of the Antimicrobial Effect of an Ethanolic Extract of Propolis in Periodontal Disease." Applied Sciences 11, no. 16 (August 13, 2021): 7463. http://dx.doi.org/10.3390/app11167463.

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Periodontal disease encompasses gingivitis and periodontitis and is one of the most common chronic infections in the adult population. This study aimed to evaluate the influence of Spanish propolis extract (EEP) on the effect of the clinical and microbiological parameters as an adjuvant to scaling and root planning in patients undergoing supportive periodontal therapy (SPT). Forty chronic periodontitis patients were randomly assigned into two groups for the treatment. In the control group (n = 20), the sites were treated by scaling and root planing followed by gingival irrigation with physiolo

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Rahim, Muhammad Imran, Andreas Winkel, Stefan Lienenklaus, Nico S. Stumpp, Szymon P. Szafrański, Nadine Kommerein, Elmar Willbold, et al. "Non-Invasive Luciferase Imaging of Type I Interferon Induction in a Transgenic Mouse Model of Biomaterial Associated Bacterial Infections: Microbial Specificity and Inter-Bacterial Species Interactions." Microorganisms 8, no. 10 (October 21, 2020): 1624. http://dx.doi.org/10.3390/microorganisms8101624.

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The performance of biomaterials is often compromised by bacterial infections and subsequent inflammation. So far, the conventional analysis of inflammatory processes in vivo involves time-consuming histology and biochemical assays. The present study employed a mouse model where interferon beta (IFN-β) is monitored as a marker for non-invasive rapid detection of inflammation in implant-related infections. The mouse model comprises subcutaneous implantation of morphologically modified titanium, followed by experimental infections with four taxonomically diverse oral bacteria: Streptococcus orali

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Oscarsson and Johansson. "Comment from the Editor to the Special Issue: “Periodontitis: From Dysbiotic Microbial Immune Response to Systemic Inflammation”." Journal of Clinical Medicine 8, no. 10 (October 16, 2019): 1706. http://dx.doi.org/10.3390/jcm8101706.

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The human oral cavity contains a large number of different microbial habitats. When microbes from the oral indigenous flora colonize the interspace between the tooth and the connective tissue, they induce an inflammatory response. If the microbes are in sufficient numbers, and release components that cause an imbalance in the host inflammatory response, degenerative processes in the surrounding tissues are induced, ultimately resulting in periodontal disease. The disease progress depends on bacterial load, the composition of the microbial community, and host genetic factors. The two most studi

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Vickerman, M. M., K. A. Brossard, D. B. Funk, A. M. Jesionowski, and S. R. Gill. "Phylogenetic analysis of bacterial and archaeal species in symptomatic and asymptomatic endodontic infections." Journal of Medical Microbiology 56, no. 1 (January 1, 2007): 110–18. http://dx.doi.org/10.1099/jmm.0.46835-0.

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Phylogenetic analysis of bacterial and archaeal 16S rRNA was used to examine polymicrobial communities within infected root canals of 20 symptomatic and 14 asymptomatic patients. Nucleotide sequences from ∼750 clones amplified from each patient group with universal bacterial primers were matched to the Ribosomal Database Project II database. Phylotypes from 37 genera representing Actinobacteria, Bacteroidetes, Firmicutes, Fusobacteria and Proteobacteria were identified. Results were compared to those obtained with species-specific primers designed to detect Prevotella intermedia, Porphyromonas

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