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1

1925-, Conn Harold O., ed. TIPS: Transjugular intrahepatic portosystemic shunts. New York: Igaku-Shoin, 1996.

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2

(Editor), Harold O. Conn, Julio Palmaz (Editor), Josef Rosch (Editor), and Martin Rossle (Editor), eds. Tips: Transjugular Intrahepatic Portosystemic Shunts. Igaku-Shoin Medical Pub, 1996.

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3

TIPS: Transjugular intrahepatic portosystemic shunts. Igaku-Shoin, 1996.

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4

Grosso, Maurizio, Gerd Noldge, and Cesare Fava. Transjugular Intrahepatic Portosystemic Shunt (TIPS) indications, techniques and results. Idelson-Gnocchi Ltd. Publishing, 1998.

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5

Kinney, Thomas, and Kazim Narsinh. Use of Prolapsing Guidewire to Secure Portal Venous Access During the TIPS Procedure. Edited by S. Lowell Kahn, Bulent Arslan, and Abdulrahman Masrani. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199986071.003.0075.

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Perhaps the most critical portion of the transjugular intrahepatic portosystemic shunt procedure involves obtaining secure portal venous access. An acute angle of entry into the portal venous system during intrahepatic portosystemic shunt creation can make retrograde advancement of a guidewire into the splenic or superior mesenteric vein difficult. However, securing access from the jugular access site to the portal system with a reliable guidewire is of critical importance during the procedure. This chapter presents a technique to advance a flexible-tip guidewire antegrade into right portal vein branches prior to prolapsing the guidewire into the main portal vein to secure transjugular portal venous access.
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6

Irani, Zubin, and Sara Zhao. Adjustable Small-Diameter TIPS. Edited by S. Lowell Kahn, Bulent Arslan, and Abdulrahman Masrani. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199986071.003.0081.

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Transjugular intrahepatic portosystemic shunt (TIPS) was first described by Rosch et al. in 1969, and in 1982, Colopinto et al. described its first clinical application in a patient with cirrhosis and variceal hemorrhage. It was not until 1988 that the first metal-lined shunt was created, and in 1997 the first polytetrafluoroethylene (PTFE)-lined stent was used in humans for shunt revision after stenosis, created by pinning the Gore PTFE graft material between two metal stents. Introduced in 2000, the Viatorr stent graft is now the most commonly used device for TIPS. One of the major side effects of TIPS creation is hepatic encephalopathy (HE). This chapter discusses the adjustable small-diameter transjugular intrahepatic portosystemic shunt.
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7

Ferral, Hector. Optimal Imaging Techniques of the Portal Vasculature During TIPS Creation: Use of the CO2 Portogram. Edited by S. Lowell Kahn, Bulent Arslan, and Abdulrahman Masrani. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199986071.003.0074.

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Transjugular intrahepatic portosystemic shunt creation is one of the most complex interventional procedures. It requires skills in imaging, vessel catheterization, guidewire techniques, balloon angioplasty, endovascular stent deployment, and embolization techniques. The key step during this procedure is obtaining access into the portal vein. This chapter discusses how to perform a CO2 portogram to obtain access to the portal vein during the creation of a transjugular intrahepatic portosystemic shunt (TIPS). The CO2 portogram may be performed with an angiographic catheter wedged in the hepatic vein, with an occlusion balloon inflated within the hepatic vein, or with the transhepatic needle within the liver parenchyma—the so-called “intraparenchymal” injection. Those performing a CO2 portogram should have knowledge of CO2 and a user-friendly CO2 delivery system to avoid common CO2 complications.
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8

Williams, Ashleigh, and John Christie. Hepatic disease. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198719410.003.0007.

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This chapter describes the anaesthetic management of the patient with liver disease and its sequelae. Acute liver failure and chronic liver failure are discussed, together with their anaesthetic implications on coagulation and drug metabolism. Major sequelae of liver disease are discussed, including portal hypertension, varices, and hepatorenal syndrome. The preoperative investigation and optimization, treatment, and anaesthetic management of the patient with liver failure are described. The investigation and management of post-operative liver dysfunction are described. The anaesthetic management of acute oesophageal variceal haemorrhage and transjugular intrahepatic portosystemic shunt (TIPSS) are described.
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9

Plotnik, Adam N., and Stephen Kee. Advancing the TIPS Sheath Through a Difficult Cirrhotic Liver: Pay It Forward Off the Balloon. Edited by S. Lowell Kahn, Bulent Arslan, and Abdulrahman Masrani. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199986071.003.0076.

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The “pay it forward off the balloon” technique for advancing the transjugular intrahepatic portosystemic shunt (TIPS) sheath may be employed during a difficult TIPS case when the interventionalist has already accessed the portal vein but cannot get the standard 10 Fr TIPS sheath through the fibrotic tract into the portal vein to thereby allow placement of a standard TIPS covered stent. In some patients, the fibrotic recoil of the parenchymal hepatic tract can be so severe that the basic balloon dilation maneuver fails. The pay it forward off the balloon technique employs the use of a 6 mm × 4-cm balloon, which is placed through the 10 Fr TIPS sheath and advanced over the wire and across the fibrotic tract into the portal vein.
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10

Kahn, S. Lowell. The Gun-Site and Percutaneous Portocaval Techniques for the Challenging TIPS. Edited by S. Lowell Kahn, Bulent Arslan, and Abdulrahman Masrani. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199986071.003.0077.

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Since its inception, the “Achilles’ heel” of the transjugular intrahepatic portosystemic shunt (TIPS) procedure has been catheterization of the portal vein from the systemic venous circulation. In the majority of TIPS procedures, the portal vein is readily identified with conventional technique and the procedure is completed in no more than 60–90 minutes, if not less. However, there are certain anatomic situations that can make performance of a TIPS procedure difficult. A small cirrhotic liver with an abnormal hepatic to portal venous orientation, t hrombosis or cavernous transformation of the portal vasculature, and atrophic or absent (Budd–Chiari) hepatic veins all produce unique challenges for the interventionalist. In such situations, the use of alternative TIPS techniques may be warranted. In this chapter, two alternative TIPS techniques are discussed to assist with challenging anatomy.
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11

Masrani, Abdulrahman, and Bulent Arslan. Deployment of Direct Intrahepatic Portocaval Shunt (DIPS) from a Femoral Access. Edited by S. Lowell Kahn, Bulent Arslan, and Abdulrahman Masrani. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199986071.003.0078.

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The transjugular intrahepatic portosystemic shunt (TIPS) has been shown to be effective in management of esophageal varices bleeding in patients with liver cirrhosis when endoscopic manuvers fail to control it. Ascites refractory to optimal medical therapy is another indication for TIPS procedure. Occasionally, TIPS cannot be performed due to vascular anatomical difficulties such as occluded central venous access, small hepatic veins, or portal vein occlusion. Direct intrahepatic portocaval shunt (DIPS) can be considered as an alternative option in such circumstances. DIPS is typically performed utilizing jugular access with direct puncture from the inferior vena cava (IVC) to the right portal vein. However, the interventionalist may be challenged by jugular or brachiocephalic veins occlusion. This chapter discusses perfroming DIPS procedure utilizing femoral access in a patient with bilateral occluded brachiocephalic veins and thrombosed right portal vein.
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12

Sabri, Saher S. Recanalization of Occluded TIPS Using a Transhepatic Percutaneous Technique. Edited by S. Lowell Kahn, Bulent Arslan, and Abdulrahman Masrani. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199986071.003.0080.

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Transjugular intrahepatic portosystemic shunt (TIPS) dysfunction rates have significantly decreased since the introduction of stent grafts. However, TIPS occlusion remains a recognized complication, especially when bare-metal stents are used or when the cephalad end of the stent does not extend into the inferior vena cava (IVC). Antegrade recanalization of the occluded TIPS can be routinely achieved using a coaxial or a triaxial sheath system, which provides sufficient stability and pushability to recanalize the TIPS. However, occasionally this cannot be achieved due to the difficult angulation between the IVC and the hepatic vein, poor placement of the initial TIPS short of the IVC, or long-standing occlusion of the TIPS. Retrograde recanalization of the TIPS by transhepatic percutaneous access of the TIPS using a 21 gauge needle can be performed in such situations.
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13

McCabe, Sam, Christopher Harnain, and Grigory Rozenblit. Transmesenteric Method of TIPS Placement Using Portal Access via Mini-Laparotomy. Edited by S. Lowell Kahn, Bulent Arslan, and Abdulrahman Masrani. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199986071.003.0079.

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Transmesenteric portal access via mini-laparotomy may be used as a salvage technique when standard transjugular intrahepatic portosystemic shunt (TIPS) is unsuccessful due to difficult anatomy or portal vein thrombosis. This technique allows for precise determination of both the portal and the hepatic vein branch involved in the TIPS. This method usually involves the cooperation of a surgeon, who performs a mini-laparotomy and exposes a small bowel loop in the interventional suite. A mesenteric venous branch is then cannulated, providing direct access to the portal venous system. In distinction to standard technique, the hepatic parenchymal tract is created by a puncture from the portal vein into the hepatic vein. A guidewire advanced through the puncture needle is then snared from the hepatic vein, providing through-and-through access. The TIPS can be completed using standard techniques. Upon completion, the mini-laparotomy is closed by the surgeon.
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14

Blisard, Deanna, and Ali Al-Khafaji. Diagnosis and management of variceal bleeding in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0178.

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Cirrhosis is the most common cause of portal hypertension, which subsequently leads to development of gastroesophageal varices (GEV). Generally, presence of GEV correlates with the severity of cirrhosis and variceal haemorrhage can develop when hepatic venous pressure gradient exceeds 10–12 mmHg. The gold standard for diagnosis and often treatment of GEV is oesophagogastroduodenoscopy (OGD). Management of GEV is divided into primary prophylaxis, acute haemorrhage control, and secondary prophylaxis. Primary prophylaxis includes surveillance OGD and endoscopic intervention based on the size of the varices. Management of acute variceal haemorrhage includes resuscitation and endoscopic interventions. Basic resuscitative measures to maintain haemodynamic stability, vasoconstricting agents to decrease portal pressure, and the use of prophylactic antibiotics. Endoscopic intervention includes any of variceal band ligation, variceal sclerotherapy, and variceal obturation. Radiological or surgical portosystemic shunting markedly reduces portal pressure and are clinically effective therapy for patients who fail endoscopic or pharmacological therapy. Balloon tamponade is effective in temporarily controlling oesophageal variceal haemorrhage in over 80% of patients. Its use should be restricted to patients with uncontrollable bleeding, where more definitive therapy is planned within 24 hours. Secondary prophylaxis includes endoscopy plus pharmacological therapy of non-selective β‎−blockers.
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15

Cárdenas, Andrés, and Pere Ginès. The patient with hepatorenal syndrome. Edited by Giuseppe Remuzzi. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0169_update_001.

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Hepatorenal syndrome (HRS) is a dreaded and common complication of patients with end-stage liver disease. The syndrome is characterized by functional renal failure due to renal vasoconstriction in the absence of underlying kidney pathology. The pathogenesis of HRS is the result of an extreme underfilling of the arterial circulation secondary to an arterial vasodilation located in the splanchnic circulation. This phenomenon triggers a compensatory response with activation of vasoconstrictor systems leading to intense renal vasoconstriction.Besides HRS, there are several other causes of renal failure in patients with cirrhosis including those secondary to bacterial infections, hypovolaemia, nephrotoxicity, and intrinsic renal disease. Thus, the diagnosis of HRS is based on established diagnostic criteria aimed at excluding non-functional causes of renal failure.The prognosis of patients with HRS is poor, especially in those who have a rapidly progressive course. Liver transplantation is the best option in suitable candidates, but it is not always applicable due to the short survival expectancy of listed candidates.Pharmacological therapies based on the use of vasoconstrictor drugs to reverse splanchnic vasodilation are the standard first line of therapy. The vasopressin analogue terlipressin is the best proven. Transjugular intrahepatic portosystemic shunts may be helpful in limited circumstances. Prevention of HRS can be attained with the use of albumin infusion in patients with spontaneous bacterial peritonitis, with norfloxacin in patients very advanced liver disease and with N-acetylcysteine in those with severe acute alcoholic hepatitis.
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16

Arroyo, Vicente, Mónica Guevara, and Javier Fernández. Renal failure in cirrhosis. Edited by Norbert Lameire. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0247.

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A major event in liver cirrhosis is the development of a progressive deterioration of circulatory function due to splanchnic arterial vasodilation and impairment in cardiac function. This feature determines a homeostatic activation of the renin–angiotensin–aldosterone system, sympathetic nervous system, and antidiuretic hormone. The splanchnic microcirculation is resistant to the vasoconstrictor effect of these systems. Therefore, the homeostasis of arterial pressure in cirrhosis occurs in the extrasplanchnic, mainly renal circulation. The activation of these systems produces renal fluid retention, which accumulates as ascites, and water retention and dilutional hyponatraemia. In the latest phase of cirrhosis, when circulatory dysfunction is severe, renal vasoconstriction is intense and patients develop type 2 hepatorenal syndrome (HRS) and refractory ascites.Type 1 HRS is an acute and rapidly progressive renal failure that occurs in the setting of a precipitating event, commonly an infection. Patients with type 1 HRS also present with rapid deterioration of liver function (encephalopathy, jaundice) and relative adrenal insufficiency. The mechanism of this multiorgan failure is an acute deterioration in circulatory function due to both an accentuation of arterial vasodilation and of cardiac dysfunction.There is no specific test for the diagnosis of HRS. The most accepted diagnostic criteria are those proposed by the International Ascites Club which are based on the exclusion of other types of renal failure. The course of renal failure following treatment of the precipitating event of HRS is another important diagnostic feature.The treatment of choice of tense ascites in cirrhosis is paracentesis associated with intravenous albumin infusion. Moderate sodium restriction and diuretics (spironolactone alone or associated with furosemide) are subsequently given to prevent re-accumulation of ascites. Diuretics are the treatment of choice in patients with moderate ascites. Patients with type 2 HRS and refractory ascites (not responding to diuretics) could be treated by frequent paracentesis or by the insertion of a transjugular intrahepatic portosystemic shunt (TIPS).Terlipressin plus albumin is the treatment of choice in type 1 HRS
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