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Journal articles on the topic 'Positive inotrope'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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1

Urquhart, Robert A., and Kenneth J. Broadley. "The indirect negative inotropic effects of the P1-receptor agonist, L-phenylisopropyladenosine, in guinea-pig isolated cardiac preparations: comparison with cromakalim." Canadian Journal of Physiology and Pharmacology 70, no. 6 (1992): 910–15. http://dx.doi.org/10.1139/y92-122.

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The possible mechanisms of the indirect negative inotropic responses to the P1-receptor agonist, L-phenylisopropyladenosine (L-PIA) were evaluated in electrically paced (2 Hz, 5 ms pulse width, voltage 50% above threshold) left atria and papillary muscles of guinea pigs. The responses were compared in naive tissues (direct effects) or after prestimulation with submaximal concentrations of either cAMP-dependent positive inotropes (isoprenaline or forskoiin) or the cAMP-independent inotrope Bay K 8644. Cumulative concentration – response curves were obtained in naive or prestimulated preparation

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2

Sakai, Mari, Tokiko Suzuki, Kengo Tomita, et al. "Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: attribution to phosphodiesterase 4 upregulation." American Journal of Physiology-Heart and Circulatory Physiology 312, no. 6 (2017): H1224—H1237. http://dx.doi.org/10.1152/ajpheart.00828.2016.

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Dobutamine has been used in septic shock for many years as an only inotrope, but its benefit has been questioned. We weighed the effects of dobutamine and milrinone as inotropes in mice with cecal ligation and puncture (CLP)-induced polymicrobial sepsis. CLP-induced septic mice exhibited significant cardiac inflammation, as indicated by greatly increased mRNAs of proinflammatory cytokines and robust infiltration of inflammatory cells in the ventricular myocardium. Elevations of plasma cardiac troponin-I showed cardiac injury in CLP mice. Noninvasive echocardiographic assessment of cardiac func

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3

&NA;. "Positive inotrope confusion helped by classification system." Inpharma Weekly &NA;, no. 911 (1993): 10. http://dx.doi.org/10.2165/00128413-199309110-00022.

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4

Ahmad, Tariq, P. Elliott Miller, Megan McCullough, et al. "Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials." European Journal of Heart Failure 21, no. 9 (2019): 1064–78. http://dx.doi.org/10.1002/ejhf.1557.

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5

Bose, D., T. Kobayashi, R. A. Bouchard, and L. V. Hryshko. "Scattered light intensity fluctuation in the canine ventricular myocardium: correlation with inotropic drug effect." Canadian Journal of Physiology and Pharmacology 66, no. 9 (1988): 1232–38. http://dx.doi.org/10.1139/y88-203.

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Scattered light intensity fluctuation (SLIF) of coherent light by a strip of ventricular muscle during diastole is believed to be due to asynchronous cellular motion within the myocyte as a result of spontaneous release of Ca from the sarcoplasmic reticulum. Previous studies have shown a correlation between inotropic agents, such as ouabain and elevated extracellular Ca or decreased extracellular Na, and SLIF. The purpose of this study was to see if this correlation could be extended to other inotropic agents. The digitalis genin, ouabagenin, produces inotropy by increasing intracellular free

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6

Greenberg, Stanley S., Jeff Paul, and Alan Luisi. "General pharmacology of CK-2130: A new selective positive inotrope." Drug Development Research 21, no. 4 (1990): 301–24. http://dx.doi.org/10.1002/ddr.430210405.

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7

Sikkel, Markus B., Carl Hayward, Kenneth T. MacLeod, Sian E. Harding, and Alexander R. Lyon. "SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope." British Journal of Pharmacology 171, no. 1 (2013): 38–54. http://dx.doi.org/10.1111/bph.12472.

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8

Tocchetti, Carlo, Jeffrey Froehlich, Hector Valdivia, et al. "Nitroxyl: A positive inotrope enhancing SR CA2+ cycling in isolated myocytes." Journal of Molecular and Cellular Cardiology 42, no. 6 (2007): S109. http://dx.doi.org/10.1016/j.yjmcc.2007.03.246.

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9

Mazza, Rosa, Alfonsina Gattuso, Sandra Imbrogno, et al. "Selenoprotein T as a new positive inotrope in the goldfish, Carassius auratus." Journal of Experimental Biology 222, no. 11 (2019): jeb201202. http://dx.doi.org/10.1242/jeb.201202.

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10

Koch, Sheryl E., Michael Tranter, Nathan Robbins, et al. "Probenecid as a Noninjurious Positive Inotrope in an Ischemic Heart Disease Murine Model." Journal of Cardiovascular Pharmacology and Therapeutics 18, no. 3 (2012): 280–89. http://dx.doi.org/10.1177/1074248412469299.

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11

Mazza, R., A. Gattuso, M. Filice, et al. "Nesfatin-1 as a new positive inotrope in the goldfish (Carassius auratus) heart." General and Comparative Endocrinology 224 (December 2015): 160–67. http://dx.doi.org/10.1016/j.ygcen.2015.08.003.

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12

Combs, Donald W., Marianne S. Rampulla, Stanley C. Bell, et al. "6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents." Journal of Medicinal Chemistry 33, no. 1 (1990): 380–86. http://dx.doi.org/10.1021/jm00163a061.

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13

Levine, Barbara S. "Intermittent Positive Inotrope Infusion in the Management of End-Stage, Low-Output Heart Failure." Journal of Cardiovascular Nursing 14, no. 4 (2000): 76–93. http://dx.doi.org/10.1097/00005082-200007000-00006.

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14

Koch, Sheryl E., Xiaoqian Gao, Lauren Haar, et al. "Probenecid: Novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation." Journal of Molecular and Cellular Cardiology 53, no. 1 (2012): 134–44. http://dx.doi.org/10.1016/j.yjmcc.2012.04.011.

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15

KAZZIHA, S. "Insights into the mechanism of a new positive inotrope: Endothelin: Role of the endocardium." Journal of Molecular and Cellular Cardiology 24 (June 1992): S61. http://dx.doi.org/10.1016/0022-2828(92)93039-m.

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16

Mathew, Rebecca, Sarah M. Visintini, F. Daniel Ramirez, et al. "Efficacy of milrinone and dobutamine in low cardiac output states: Systematic review and meta-analysis." Clinical and Investigative Medicine 42, no. 2 (2019): E26–32. http://dx.doi.org/10.25011/cim.v42i2.32813.

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 Purpose: Patients in cardiac intensive care units (ICU) are admitted with increasingly higher disease acuity and a larger burden of non-cardiac critical illness. Accordingly, positive inotropes are being used with increased frequency and little comparative data to support drug selection. We compared the effectiveness and safety of dobutamine and milrinone in low cardiac output states (LCOS) and/or cardiogenic shock (CS).  Methods: We performed a systematic review comparing dobutamine to milrinone on all-cause mortality, length of stay in the ICU (LOS-ICU), length of stay in

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17

Hanouz, JL, JM Martino, PY Gueugniaud, B. Vivien, B. Riou та P. Coriat. "L'isoflurane et le sévoflurane potentialisent la réponse inotrope positive induite par les stimulations α- et β-adrenergiques". Annales Françaises d'Anesthésie et de Réanimation 16, № 6 (1997): 669. http://dx.doi.org/10.1016/s0750-7658(97)86135-7.

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18

Tobia, A., R. Falotico, D. Simon, et al. "Bemoradan: a novel orally potent positive inotrope/peripheral vasodilator with beneficial hemodynamics in congestive heart failure patients." European Journal of Pharmacology 183, no. 3 (1990): 776–77. http://dx.doi.org/10.1016/0014-2999(90)92583-5.

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19

Fellahi, Jean-Luc, Marc-Olivier Fischer, Georges Daccache, Jean-Louis Gerard, and Jean-Luc Hanouz. "Positive Inotropic Agents in Myocardial Ischemia–Reperfusion Injury." Anesthesiology 118, no. 6 (2013): 1460–65. http://dx.doi.org/10.1097/aln.0b013e31828f4fc3.

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Abstract Positive inotropic agents should be used judiciously when managing surgical patients with acute myocardial ischemia–reperfusion injury, as use of these inotropes is not without potential adverse effects.

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20

Tobias, A. H., B. K. Slinker, R. D. Kirkpatrick, and K. B. Campbell. "Functional effects of EMD-57033 in isovolumically beating isolated rabbit hearts." American Journal of Physiology-Heart and Circulatory Physiology 271, no. 1 (1996): H51—H58. http://dx.doi.org/10.1152/ajpheart.1996.271.1.h51.

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The results of isolated myocyte and cardiac muscle experiments indicate that inotropic agents that increase responsiveness of myofilaments to Ca2+ (so-called Ca2+ sensitizers) may prolong myocardial contraction and increase diastolic tone, but the importance of these effects in the whole heart is unclear. Therefore, we studied the effects of the Ca2+ sensitizer EMD-57033 (EMD) on left ventricular (LV) contractile events and passive properties in isovolumically beating isolated rabbit hearts that were buffer perfused at 30 degrees C. Several LV pressure and timing variables were evaluated, incl

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21

Saleem, Umber, Berend J. van Meer, Puspita A. Katili, et al. "Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes." Toxicological Sciences 176, no. 1 (2020): 103–23. http://dx.doi.org/10.1093/toxsci/kfaa058.

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Abstract Animal models are 78% accurate in determining whether drugs will alter contractility of the human heart. To evaluate the suitability of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for predictive safety pharmacology, we quantified changes in contractility, voltage, and/or Ca2+ handling in 2D monolayers or 3D engineered heart tissues (EHTs). Protocols were unified via a drug training set, allowing subsequent blinded multicenter evaluation of drugs with known positive, negative, or neutral inotropic effects. Accuracy ranged from 44% to 85% across the platform-c

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22

Wang, Guan-Ying, Diana T. McCloskey, Sally Turcato, Philip M. Swigart, Paul C. Simpson та Anthony J. Baker. "Contrasting inotropic responses to α1-adrenergic receptor stimulation in left versus right ventricular myocardium". American Journal of Physiology-Heart and Circulatory Physiology 291, № 4 (2006): H2013—H2017. http://dx.doi.org/10.1152/ajpheart.00167.2006.

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The left ventricle (LV) and right ventricle (RV) have differing hemodynamics and embryological origins, but it is unclear whether they are regulated differently. In particular, no previous studies have directly compared the LV versus RV myocardial inotropic responses to α1-adrenergic receptor (α1-AR) stimulation. We compared α1-AR inotropy of cardiac trabeculae from the LV versus RV of adult mouse hearts. As previously reported, for mouse RV trabeculae, α1-AR stimulation with phenylephrine (PE) caused a triphasic contractile response with overall negative inotropy. In marked contrast, LV trabe

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23

Wong, Judith JM, Stephanie X. Ho, Alpha Omega CJ Lee, et al. "Positive Fluid Balance is Associated with Poor Clinical Outcomes in Paediatric Severe Sepsis and Septic Shock." Annals of the Academy of Medicine, Singapore 48, no. 9 (2019): 290–97. http://dx.doi.org/10.47102/annals-acadmedsg.v48n9p290.

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Introduction: Growing evidence suggests there is potential harm associated with excess fluid in critically ill children. This study aimed to evaluate the association between percentage fluid overload (%FO) and paediatric intensive care unit (PICU) mortality in children with severe sepsis and septic shock. Materials and Methods: Patients with severe sepsis and septic shock admitted to the PICU were identified through discharge codes. Data on clinical characteristics, fluid input and output were collected. %FO was calculated as: (total daily input - total daily output [L]/admission body weight [

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24

Borzak, S., S. Murphy, and J. D. Marsh. "Mechanisms of rate staircase in rat ventricular cells." American Journal of Physiology-Heart and Circulatory Physiology 260, no. 3 (1991): H884—H892. http://dx.doi.org/10.1152/ajpheart.1991.260.3.h884.

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We studied the steady-state rate staircase in isolated rat ventricular cells stimulated at frequencies ranging up to 6 Hz at 37 degrees C. When contractility was measured as displacement of the cell edge, amplitude of motion decreased while stimulation rates were increased from rest to 1 Hz (negative staircase). With further increases in the rate of stimulation to 6 Hz, amplitude of motion increased for each increment in stimulation rate (positive staircase). Ryanodine at a concentration of 100 nM was a negative inotrope and abolished the rested state contraction and the negative staircase see

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25

Kaygisiz, Ziya, H. Ozden, N. Erkasap, et al. "Positive inotropic, positive chronotropic and coronary vasodilatory effects of rat amylin: mechanisms of amylin-induced positive inotropy." Acta Physiologica Hungarica 97, no. 4 (2010): 362–74. http://dx.doi.org/10.1556/aphysiol.97.2010.4.2.

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26

Lee, Sang-Hoon, Tae-Yoon Lee, Jong-Hyeon Jeong, and Young-Koog Cheon. "Clinical Significance of the Neutrophil–Lymphocyte Ratio as an Early Predictive Marker for Adverse Outcomes in Patients with Acute Cholangitis." Medicina 58, no. 2 (2022): 255. http://dx.doi.org/10.3390/medicina58020255.

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Background and objectives: Acute cholangitis can be life-threatening if not recognized early. We investigated the predictive value of the neutrophil–lymphocyte ratio (NLR) in acute cholangitis. Materials and Methods: We retrospectively evaluated 206 patients with acute cholangitis who underwent biliary drainage. The severity of acute cholangitis was graded according to the Tokyo 2018 guideline. Patients were dichotomized according to the acute cholangitis severity (mild/moderate vs. severe), the presence of shock requiring a vasopressor/inotrope, and blood culture positivity. The baseline NLR,

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27

Robertson, David W., Joseph H. Krushinski, and Don Kau. "Synthesis of 14C- and 2H-labeled 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one (LY195115), an orally effective positive inotrope." Journal of Labelled Compounds and Radiopharmaceuticals 23, no. 4 (1986): 343–54. http://dx.doi.org/10.1002/jlcr.2580230402.

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28

Zaeem, Faisal, Dalia Giedriemiene, Craig Coleman, et al. "CRT-D Therapy in Patients with Decompensated NYHA Class-Four CHF." Cardiology Research and Practice 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/319205.

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Background. ACC-HRS Guidelines for Cardiac Resynchronization Therapy ICD implantation (CRT-D) do not include patients with advanced nonambulatory NYHA class-four CHF due to an expectation of limited survival. There is little data available from these large multicenter randomized studies to support or refute this claim.Purpose. We evaluated the outcomes of patients with advanced nonambulatory NYHA class-four CHF who received CRT-D devices as an attempt to improve the clinical status and promote hospital discharge.Methods. Sixteen (of our six hundred and seventy CRT-D patients) were classified a

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29

Pathak, Santosh, Nagendra Chaudhary, Prativa Dhakal, Sanjay Ray Yadav, Binod Kumar Gupta, and Om Prakash Kurmi. "Comparative Study of Chikungunya Only and Chikungunya-Scrub Typhus Coinfection in Children: Findings from a Hospital-Based Observational Study from Central Nepal." International Journal of Pediatrics 2021 (April 20, 2021): 1–6. http://dx.doi.org/10.1155/2021/6613564.

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Objectives. Chikungunya and scrub typhus infection are important causes of undifferentiated fever in tropical zones. The clinical manifestations in both conditions are nonspecific and often overlap. This study compares the clinical manifestations and the outcome of chikungunya with chikungunya-scrub typhus coinfection in children. Methods. A hospital-based observational study was conducted in children below 15 years of age over 16-month duration in 2017-2018. Chikungunya was diagnosed by IgM ELISA. All positive chikungunya cases were subjected to scrub typhus testing, dengue testing, leptospir

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30

Garlid, Keith D., Paolo E. Puddu, Philippe Pasdois, et al. "Inhibition of cardiac contractility by 5-hydroxydecanoate and tetraphenylphosphonium ion: a possible role of mitoKATP in response to inotropic stress." American Journal of Physiology-Heart and Circulatory Physiology 291, no. 1 (2006): H152—H160. http://dx.doi.org/10.1152/ajpheart.01233.2005.

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This study investigates the role of the mitochondrial ATP-sensitive K+ channel (mitoKATP) in response to positive inotropic stress. In Langendorff-perfused rat hearts, inotropy was induced by increasing perfusate calcium to 4 mM, by adding 80 μM ouabain or 0.25 μM dobutamine. Each of these treatments resulted in a sustained increase in rate-pressure product (RPP) of ∼60%. Inhibition of mitoKATP by perfusion of 5-hydroxydecanoate (5-HD) or tetraphenylphosphonium before induction of inotropic stress resulted in a marked attenuation of RPP. Inhibition of mitoKATP after induction of stress caused

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31

Lee, C. O. "200 years of digitalis: the emerging central role of the sodium ion in the control of cardiac force." American Journal of Physiology-Cell Physiology 249, no. 5 (1985): C367—C378. http://dx.doi.org/10.1152/ajpcell.1985.249.5.c367.

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Digitalis has been used therapeutically for two centuries, but the mechanism by which it enhances the ability of cardiac muscle to produce force (the positive inotropic effect) has not been fully elucidated. The major controversy concerns the question of whether the inhibition of the Na+-K+ pump by digitalis, particularly at low (therapeutic) concentrations, increases the intracellular Na+ concentration and thus is causally related to the positive inotropic effect. Na+-selective microelectrodes, introduced recently, have made it possible to measure small changes in intracellular Na+ activity (

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32

Koloskova, O. K., R. V. Tkachuk, M. N. Garas, T. M. Bilous, L. I. Romanchuk, and D. I. Sorochan. "Guillain — Barré syndrome following asymptomatic COVID-19 in an adolescent: a clinical case." CHILD`S HEALTH 17, no. 1 (2022): 43–47. http://dx.doi.org/10.22141/2224-0551.17.1.2022.1491.

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Guillain — Barré syndrome (GBS) is a rare disease that occurs with an approximate incidence of 1.7 cases per 100,000 children in the pediatric population. The gender difference in the prevalence of the disease is characterized by a 20% greater vulnerability of boys than girls. The exact cause of Guillain — Barre syndrome is unknown; however, it can occur after respiratory infection by Haemophilus influenzae, recent or ongoing Campylobacter jejuni infection or poliovirus. Since the beginning of the COVID-19 pandemic, there have been some reported Guillain — Barré diagnoses among adults follow

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33

Zabala, M. S., J. Herreros, O. Gil, I. Iglesias, J. Barba, and E. Alegría. "Dynamic Cardiomyoplasty in a Patient with End-Stage Cardiomyopathy." International Journal of Artificial Organs 15, no. 8 (1992): 488–92. http://dx.doi.org/10.1177/039139889201500808.

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Dynamic cardiomyoplasty is a relatively new surgical procedure by which a transformed fatigue-resistant skeletal muscle wrapped around the heart is stimulated to contract in synchrony with it, thereby augmenting the ventricular functions of a failing heart. We performed a cardiomyoplasty with latissimus dorsii (LD) in a patient who was refused the heart transplant programme because of pulmonary hypertension and psychosocial contraindications. The patient was 34 years old, functional class grade IV of the New York Heart Association (NYHA), with a three-month history, due to ischemic cardiomyopa

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34

GOODWIN, Andrew T., Mohamed AMRANI, Caroline C. GRAY, Jay JAYAKUMAR, Adrian J. MARCHBANK, and Magdi H. YACOUB. "Differential effects of endothelin-1 on isolated working rat hearts before and after ischaemia and reperfusion." Clinical Science 103, s2002 (2002): 189S—193S. http://dx.doi.org/10.1042/cs103s189s.

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Endothelin (ET) may have both detrimental (reduced coronary flow) and beneficial effects (positive inotrope, reduced arrhythmogenesis) following ischaemia. We examined the effects of ET on cardiac function during reperfusion following prolonged hypothermic cardioplegic arrest in a protocol mimicking cardiac transplantation. Isolated working rat hearts were perfused with Krebs buffer to which increasing concentrations of ET-1 or sarafotoxin S6c had been added. Identical experiments were performed after 4h of cardioplegic arrest at 4°C. Under pre-ischaemic conditions ET-1 caused a dose-dependent

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35

Cowley, Patrick M., Guanying Wang, Audrey N. Chang та ін. "The α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium". American Journal of Physiology-Heart and Circulatory Physiology 309, № 5 (2015): H888—H896. http://dx.doi.org/10.1152/ajpheart.00042.2015.

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Dysfunction of the right ventricle (RV) is closely related to prognosis for patients with RV failure. Therefore, strategies to improve failing RV function are significant. In a mouse RV failure model, we previously reported that α1-adrenergic receptor (α1-AR) inotropic responses are increased. The present study determined the roles of both predominant cardiac α1-AR subtypes (α1A and α1B) in upregulated inotropy in failing RV. We used the mouse model of bleomycin-induced pulmonary fibrosis, pulmonary hypertension, and RV failure. We assessed the myocardial contractile response in vitro to stimu

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36

Todaka, Koji, Jie Wang, Geng-Hua Yi, et al. "Effect of BAY y 5959 on myocardial function and metabolism in normal and failing hearts." American Journal of Physiology-Heart and Circulatory Physiology 274, no. 5 (1998): H1560—H1568. http://dx.doi.org/10.1152/ajpheart.1998.274.5.h1560.

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BAY y 5959 is a dihydropyridine derivative with positive inotropic actions mediated by a direct increase in intracellular calcium. We characterized the direct myocardial actions of this new agent in hearts isolated from seven normal dogs and from five dogs with repeated coronary microembolization-induced heart failure. Inotropic actions of BAY y 5959 were accompanied by little effect on duration of contraction and by prolongation of the monophasic action potential (MAP); in contrast, isoproterenol decreased contraction and MAP durations. Whereas inotropic responsiveness to isoproterenol was bl

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37

Kurobane, Itsuo, Dhirendra L. Nandi, and George T. Okita. "Association of the positive inotropic action of ouabain with a second species of digitalis receptors." Canadian Journal of Physiology and Pharmacology 63, no. 5 (1985): 476–86. http://dx.doi.org/10.1139/y85-083.

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Studies were conducted to determine whether Na–K ATPase or a second species of digitalis receptors in canine cardiac sarcolemma membrane preparations is associated with the positive inotropic action of nontoxic concentrations of ouabain. [3H]ouabain association and dissociation experiments using highly enriched sarcolemma preparations from canine ventricle indicate the presence of two species of ouabain binding receptors. Ouabain binding to Na–K ATPase of the sarcolemma preparation requires supporting ligands and is characterized by fast association and very slow dissociation in vitro. The sec

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38

Morrill, Paula. "Pharmacotherapeutics of Positive Inotropes." AORN Journal 71, no. 1 (2000): 171–85. http://dx.doi.org/10.1016/s0001-2092(06)62180-7.

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39

Nishio, Manabu, Stuart W. Ruch, and J. Andrew Wasserstrom. "Positive inotropic effects of ouabain in isolated cat ventricular myocytes in sodium-free conditions." American Journal of Physiology-Heart and Circulatory Physiology 283, no. 5 (2002): H2045—H2053. http://dx.doi.org/10.1152/ajpheart.00203.2002.

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The inotropic and toxic effects of cardiac steroids are thought to result from Na+-K+-ATPase inhibition, with elevated intracellular Na+(Na[Formula: see text])causing increased intracellular Ca2+(Ca[Formula: see text]) via Na-Ca exchange. We studied the effects of ouabain on cat ventricular myocytes in Na+-free conditions where the exchanger is inhibited. Cell shortening and Ca[Formula: see text] transients (with fluo 4-AM fluorescence) were measured under voltage clamp during exposure to Na+-free solutions [LiCl or N-methyl-d-glucamine (NMDG) replacement]. Ouabain enhanced contractility by 12

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40

Heber, Dieter, Jens Jürgens, Ursula Ravens, and Jörg Schumann. "Positiv inotrop wirkende Verbindungen, II Synthese 5- und 6-substituierter Phenanthridine und Untersuchungen zum Mechanismus ihrer positiv inotropen Wirkung." Archiv der Pharmazie 321, no. 11 (1988): 787–92. http://dx.doi.org/10.1002/ardp.19883211104.

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41

Parikh, Jaimit, Timothy Rumbell, Xenia Butova, et al. "Generative adversarial networks for construction of virtual populations of mechanistic models: simulations to study Omecamtiv Mecarbil action." Journal of Pharmacokinetics and Pharmacodynamics 49, no. 1 (2021): 51–64. http://dx.doi.org/10.1007/s10928-021-09787-4.

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AbstractBiophysical models are increasingly used to gain mechanistic insights by fitting and reproducing experimental and clinical data. The inherent variability in the recorded datasets, however, presents a key challenge. In this study, we present a novel approach, which integrates mechanistic modeling and machine learning to analyze in vitro cardiac mechanics data and solve the inverse problem of model parameter inference. We designed a novel generative adversarial network (GAN) and employed it to construct virtual populations of cardiac ventricular myocyte models in order to study the actio

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42

Brown, Mary Beth, Evandro Neves, Gary Long, et al. "High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 312, no. 2 (2017): R197—R210. http://dx.doi.org/10.1152/ajpregu.00358.2016.

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Exercise is beneficial in pulmonary arterial hypertension (PAH), although studies to date indicate little effect on the elevated pulmonary pressures or maladaptive right ventricle (RV) hypertrophy associated with the disease. For chronic left ventricle failure, high-intensity interval training (HIIT) promotes greater endothelial stimulation and superior benefit than customary continuous exercise training (CExT); however, HIIT has not been tested for PAH. Therefore, here we investigated acute and chronic responses to HIIT vs. CExT in a rat model of monocrotaline (MCT)-induced mild PAH. Six week

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Yaku, H., B. K. Slinker, T. Mochizuki, B. H. Lorell, and M. M. LeWinter. "Use of 2,3-butanedione monoxime to estimate nonmechanical VO2 in rabbit hearts." American Journal of Physiology-Heart and Circulatory Physiology 265, no. 3 (1993): H834—H842. http://dx.doi.org/10.1152/ajpheart.1993.265.3.h834.

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The purpose of the present study was to evaluate the feasibility of partitioning myocardial O2 consumption (VO2) into mechanical and nonmechanical components in the whole heart preparation using a negative inotrope, 2,3-butanedione monoxime (BDM), which has been reported to have a selective effect on the contractile proteins in a low concentration range (< 6 mM). In six isolated bovine red blood cell-perfused rabbit hearts, VO2 and force-time integral (FTI) were measured during infusion of varying concentrations of BDM at a constant left ventricular volume chosen such that control left vent

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Leone, Marc, Jacques Alban??se, and Claude Martin. "Positive inotropic stimulation." Current Opinion in Critical Care 8, no. 5 (2002): 395–403. http://dx.doi.org/10.1097/00075198-200210000-00005.

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45

Tande, Pål M., and Helge Refsum. "Class III Antiarrhythmic Action Linked with Positive Inotropy: Acute Electrophysiological and Inotropic Effects of Amiodaronein Vitro." Pharmacology & Toxicology 66, no. 1 (1990): 18–22. http://dx.doi.org/10.1111/j.1600-0773.1990.tb00694.x.

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46

Rustamov, Shavkat Yu, Inoyat Z. Jumayev, Sadriddin N. Boboev, Eldor B. Ibragimov, Pulat B. Usmanov, and Sherzod N. Zhurakulov. "Description of the Mechanism of Positive Inotropic Action of the Isoquinoline Alkaloid F-18." Cardiology Research and Reports 3, no. 3 (2021): 01–04. http://dx.doi.org/10.31579/2692-9759/023.

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This study evaluated the mechanism of inotropic effect of an isoquinoline alkaloid derivative, 1-(2´-bromine-4´,5´-dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4- tetrahydroisoquinoline (F-18) using electrically stimulated rat left ventricular papillary muscle of rat. The F-18 alkaloid have been shown to have positive inotropic effect on papillary muscle contraction activity, IC50 value -14,6 µM. Са2+L-channel blocker - nifedipine was used in experiments. Inotropic effects of F-18 isoquinoline alkaloid on cardiomyocytes were suggested, based on results obtained in experiments carried in cardiomyocytes

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Bozhinovska, Marija, Gordana Taleska, Andrej Fabian, and Maja Å oÅ¡tariÄ. "The Role of Levosimendan in Patients with Decreased Left Ventricular Function Undergoing Cardiac Surgery." Open Access Macedonian Journal of Medical Sciences 4, no. 3 (2016): 510–16. http://dx.doi.org/10.3889/oamjms.2016.071.

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The postoperative low cardiac output is one of the most important complications following cardiac surgery and is associated with increased morbidity and mortality. The condition requires inotropic support to achieve adequate hemodynamic status and tissue perfusion. While catecholamines are utilised as a standard therapy in cardiac surgery, their use is limited due to increased oxygen consumption. Levosimendan is calcium sensitising inodilatator expressing positive inotropic effect by binding with cardiac troponin C without increasing oxygen demand. Furthermore, the drug opens potassium ATP (KA

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Colucci, Wilson S. "Positive Inotropic/Vasodilator Agents." Cardiology Clinics 7, no. 1 (1989): 131–44. http://dx.doi.org/10.1016/s0733-8651(18)30462-4.

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Steiness, Eva. "POSITIVE INOTROPIC DRUGS-DIGITALIS." Acta Medica Scandinavica 219, S707 (2009): 63–64. http://dx.doi.org/10.1111/j.0954-6820.1986.tb18117.x.

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SCHOLZ, H., R. BRUCKNER, A. MUGGE, and C. REUPCKE. "Myocardial alpha-adrenoceptors and positive inotropy." Journal of Molecular and Cellular Cardiology 18 (1986): 79–87. http://dx.doi.org/10.1016/s0022-2828(86)80463-1.

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