Academic literature on the topic 'Post completion review (PCR)'
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Journal articles on the topic "Post completion review (PCR)"
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Saif-Ur-Rahman, K. M., Kavita Kothari, Corinna Sadlier, et al. "Effect of COVID-19 vaccines for the treatment of people with post-COVID-19 condition: a rapid review." HRB Open Research 5 (October 25, 2022): 69. http://dx.doi.org/10.12688/hrbopenres.13638.1.
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Background: Vaccination for coronavirus disease 2019 (COVID-19) has demonstrated reduced risk of hospitalisation and death against more recent variants of COVID-19. Some studies suggested improvements in patients with post-COVID-19 condition (PCC) following vaccination. We systematically explored available evidence on the effect of COVID-19 vaccines for the treatment of people with PCC. Methods: We conducted a rapid review of the literature following systematic approaches. We searched Medline (OVID), EMBASE (Elsevier), ClinicalTrials.gov, and the International Clinical Trials Registry Platform (ICTRP) for randomised trials, non-randomised trials, controlled before-after studies, and interrupted time-series studies of the effect of COVID-19 vaccines for treating people with PCC. Two independent review authors screened citations. Two review authors extracted data independently. We had planned to assess the risk of bias and use the GRADE approach (Grading of Recommendations, Assessment, Development, and Evaluation) to assess the certainty of evidence if there were completed studies. Results: We identified two ongoing randomised controlled trials. Both trials examine the effectiveness of therapeutic vaccines on PCC. The anticipated completion date of the CIMAvax-EGFA trial is January 2023, and the completion date of the COVID-19 mRNA vaccine trial is not stated. Conclusions: There is currently an absence of high‐quality evidence evaluating the effectiveness of COVID-19 vaccines for treating people with post-COVID-19 condition. The absence of published studies and only two ongoing trials highlight the need for additional studies on the effectiveness of vaccines for PCC. We recommend that researchers consider PCC as per the definition provided by the World Health Organization and use the available core outcome set for PCC in deciding which outcomes to measure and report in the trials. PROPSERO registration: CRD42022330821 (20/06/2022)
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Saif-Ur-Rahman, K. M., Kavita Kothari, Corinna Sadlier, et al. "Effect of COVID-19 vaccines for the treatment of people with post-COVID-19 condition: a rapid review." HRB Open Research 5 (October 11, 2023): 69. http://dx.doi.org/10.12688/hrbopenres.13638.2.
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Background: Vaccination for coronavirus disease 2019 (COVID-19) has demonstrated reduced risk of hospitalisation and death against more recent variants of COVID-19. Some studies suggested improvements in patients with post-COVID-19 condition (PCC) following vaccination. We systematically explored available evidence on the effect of COVID-19 vaccines on the treatment of people with PCC. Methods: We conducted a rapid review of the literature following systematic approaches. We searched Medline (OVID), EMBASE (Elsevier), ClinicalTrials.gov, and the International Clinical Trials Registry Platform (ICTRP) for randomised trials, non-randomised trials, controlled before-after studies, and interrupted time-series studies of the effect of COVID-19 vaccines for treating people with PCC. Two independent review authors screened citations. Two review authors extracted data independently. We had planned to assess the risk of bias and use the GRADE approach (Grading of Recommendations, Assessment, Development, and Evaluation) to assess the certainty of evidence if there were completed studies. Results: We identified two ongoing randomised controlled trials. Both trials examine the effectiveness of therapeutic vaccines on PCC. The anticipated completion date of the CIMAvax-EGFA trial is January 2023, and the completion date of the COVID-19 mRNA vaccine trial is not stated. Conclusions: There is currently an absence of high‐quality evidence evaluating the effectiveness of COVID-19 vaccines for treating people with post-COVID-19 condition. The absence of published studies and only two ongoing trials highlight the need for additional studies on the effectiveness of vaccines for PCC. We recommend that researchers consider PCC as per the definition provided by the World Health Organization and use the available core outcome set for PCC in deciding which outcomes to measure and report in the trials. PROPSERO registration: CRD42022330821 (20/06/2022)
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Zaide, Glenn B., Renee Pekmezaris, Christian N. Nouryan, et al. "Ethnicity, race, and advance directives in an inpatient palliative care consultation service." Palliative and Supportive Care 11, no. 1 (2012): 5–11. http://dx.doi.org/10.1017/s1478951512000417.
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AbstractObjective:Although race and ethnic background are known to be important factors in the completion of advance directives, there is a dearth of literature specifically investigating the effect of race and ethnicity on advance directive completion rate after palliative care consultation (PCC).Method:A chart review of all patients seen by the PCC service in an academic hospital over a 9-month period was performed. Data were compiled using gender, race, ethnicity, religion, and primary diagnosis. For this study, advance directives were defined as: “Do Not Resuscitate” (DNR) and/or “Do Not Intubate” (DNI).Results:Of the 400 medical records reviewed, 57% of patients were female and 71.3% documented their religion as Christian. The most common documented diagnosis was cancer (39.5%). Forty-seven percent reported their race as white. White patients completed more advance directives than did nonwhite patients both before (25.67% vs. 12.68%) and after (59.36% vs. 40.84%) PCC. There was a significantly higher proportion of whites who signed an advance directive after a PCC than of nonwhites (p = 0.021); of the 139 whites who did not have an advance directive at admission, 63 signed an advance directive after a PCC compared with 186/60 nonwhites (45% vs. 32%, respectively, p = 0.021). Further analysis revealed that African Americans differed from whites in the likelihood of advance directive execution rates pre-PCC, but not post-PCC.Significance of results:This study demonstrates the impact of a PCC on the completion of advance directives, on both whites and nonwhites. The PCC Intervention significantly reduced differences between whites and African Americans in completing advance directives, which have been consistently documented in the end-of-life literature.
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Broekhuis, Thom, and Michael Corbey. "Trek lering uit uw investering! Over financiële projectmonitoring en post investment analysis." Maandblad voor Accountancy en Bedrijfseconomie 98, no. (4) (2024): 105–15. https://doi.org/10.5117/mab.98.120127.
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Dit artikel laat zien dat de theorie en de praktijk van investeringsselectie veel meer gericht zijn op de fases <i>tot en met</i> de investeringsbeslissing dan <i>erná</i>. Vervolgens worden de voor- en nadelen van het systematisch financieel monitoren, bijsturen en evalueren van <i>geaccepteerde</i> investeringsprojecten geïnventariseerd. De voordelen zijn het lerend vermogen, verbeterde investeringsbesluitvorming, identificatie van succesfactoren, en realiteitszin van de cashflow(s) voor huidige en toekomstige investeringen. De nadelen (complicaties) betreffen de capaciteit en kosten van het uitvoeren, projectselectie, cultuur, en het <i>disentanglement</i> probleem. Deze bevindingen zijn onderzocht in een casestudy bij telecombedrijf KPN en bevestigen de theorie, inclusief het belang van (1) betere besluitvorming ná, en (2) "lering trekken uit". KPN ziet het <i>disentanglement</i> probleem hierbij als het grootste obstakel.
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Nabong, Christopher, Monique Chang, Sujith Kalmadi, et al. "Abstract P2-08-05: Pembrolizumab (P) added to Neoadjuvant Chemotherapy (NACT) for Triple Negative Breast Cancer (TNBC) in a community practice setting: Real World Evidence (RWE) for the effectiveness of the KN -522 regimen." Clinical Cancer Research 31, no. 12_Supplement (2025): P2–08–05—P2–08–05. https://doi.org/10.1158/1557-3265.sabcs24-p2-08-05.
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Abstract Background: NACT with platinum is the standard of care approach for operable TNBC. The KN-522 trial (N Engl J Med 2022; 386:556-7), demonstrated superior outcomes with the addition of P to NACT (KN-522 regimen), the pathological complete response (pCR) was 65% and significantly superior to 51% NACT alone (NEJM 2022; 386:556-67). The event-free survival at 36 months was 85% in the P-NACT group, compared to 77% for placebo-NACT (p&lt;0.0001). The KN522 regimen was approved by the FDA in July 2021, with rapid uptake in community practices. However, RWE demonstrates an efficacy-effectiveness gap between reported outcomes in phase 3 clinical trials to practice, including TNBC. In the control arm of the KN-522 study, 51% of patients had a pCR rate with NACT (without P). RWE for NACT is much lower, with pCR rate of 22% (n=255) from MD Anderson Cancer Ctr, TX (JCO. 2008; 26: 1275-81), and a pCR rate of 24.5% (n=421) from the BC Cancer registry (JCO 2024; 42: 16_suppl: e23274). Methods: Ironwood Cancer & Research Centers , Phoenix, AZ (ironwoodcrc.com) is a large oncology practice (includes medical, radiation oncologists, and breast surgeons) in Phoenix, AZ. We reviewed medical records for all operable TNBC cases from August 2021 to May 2024. Eligible patients had pathologically documented TNBC, operable disease, received NACT+P and were scheduled for breast surgery in the time period. This project involved retrospective chart reviews and was deemed IRB review exempt. Results: Patient characteristics: N=93, all were female. Age 29-86 yrs (median 60). 40.9% were &gt; 65 yrs and 69.9% were post-menopausal. Performance status: ECOG 0 (54.8%), ECOG 1(12.9 %) and not determined before NACT (30.1%). Nodal status was positive in 41.9% and clinical staging was 1 (5.8%), 2 (54.8%) and 3 (39.8%). NACT+P was initiated in all 93 patients, following completion of NACT, 85 had surgery (91.4%). Lumpectomy was performed in 35.5% and mastectomy in 55.9%. The pCR rate (n=85) was 51.8%. Adjuvant therapy following surgery with P was given to 77.3% of patients. Most patients who received NACT+P met relevant selection criteria similar to the KN522 study. Conclusions: Our analysis is notable for having older patients, lower percentage of ECOG 0 and higher percentage of stage 3 disease compared to the KN522 study. Major differences in our population compared to the KN522 study are : Age &gt; 65 yrs (40 vs 11%), ECOG 0 (55 vs 87%) and stage 3 disease (39 vs 25%) respectively. The pCR (RWE) for NACT without P in TNBC is 22-25%. To the best of our knowledge, this analysis is the first RWE for the KN522 regimen. The pCR is doubled to 51.7% in our study with P+NACT, results support the community use of the KN522 regimen for operable TNBC patients. Citation Format: Christopher Nabong, Monique Chang, Sujith Kalmadi, Karen Ortiz- Cruz,, Victor Chiu, Anu Batra, Leslie Klein, Emily Ho, Edgar Hernandez, Theresa Chan, Rashmi Vaidya, Joesph Di Como, Ramesh K Ramanathan, Sumeet Mendonca. Pembrolizumab (P) added to Neoadjuvant Chemotherapy (NACT) for Triple Negative Breast Cancer (TNBC) in a community practice setting: Real World Evidence (RWE) for the effectiveness of the KN -522 regimen [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2024; 2024 Dec 10-13; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(12 Suppl):Abstract nr P2-08-05.
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Pham, Huan, Qiaoling Chen, Aldon Li, Adam Baghban, Anita Cheruvanky, and Graciela Faiad. "541. Comparing Patients with Severe COVID-19 Who Improve to the Point of Discharge Following an Abbreviated Course (< 5 Days) of Remdesivir (RDV) Versus a Standard Course (≥5 Days)." Open Forum Infectious Diseases 8, Supplement_1 (2021): S372. http://dx.doi.org/10.1093/ofid/ofab466.740.
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Abstract Background The COVID-19 pandemic has negatively affected our healthcare system. Our hospitals have reached maximum capacity on several occasions. Because of the need to make beds available to new patients, some patients with severe COVID-19 who were on low flow O2 supplementation have been discharged home prior to completion of the standard (≥ 5-day) RDV course. To date, data are limited regarding clinical outcomes on these patients. Because of this, we conducted a retrospective study to assess the clinical outcomes of patients who received an abbreviated treatment course of RDV. Methods Retrospective (chart review) study Subject population All nonpregnant adult patients who were hospitalized at Kaiser Permanente Riverside Medical Center and Kaiser Permanente Moreno Valley Medical Center in 2020 with severe COVID-19 who required low flow O2 supplement during hospitalization who received RDV and discharged from hospital alive. Severe COVID-19 = positive SARS-CoV-2 PCR + evidence of lung involvement on lung imaging (X-ray or CT) + O2 saturation ≤ 94% on room air or requirement of O2 supplement. Inclusion criteria Age ≥ 18 years; Hospitalized with severe COVID-19; Given RDV Exclusion criteria Pregnancy; O2 requirement &gt; 6 L including high flow and mechanical ventilation (noninvasive or invasive); discontinuation of RDV due to adverse effects Figure 1. Patient Section. Results Mortality rate: no difference (2.1% vs 1.8%, p=0.84). 30 day post-discharge ED visit: twice more likely in the abbreviated RDV group as compared to the group receiving the standard duration (16.1% vs 8.5%, p=0.03). 30 day readmission: almost 10 times more likely in the abbreviated RDV group as compared to the group receiving the standard duration (11.9% vs 1.2%, p=&lt; 0.001). Table 1. Patient's Characteristics Table 2. Clinical Outcomes. *8 Patients Who Died Within 30-Day from Discharge Were Excluded Conclusion Though there is no difference in 30 day mortality rate, the patients who received the abbreviated RDV course are twice more likely to have ER visit and 10 times more likely to have readmission within 30 day post discharge despite more patients in the abbreviated course receiving steroids. The findings suggest that completing an at least 5-day course of RDV may be beneficial even in patients who demonstrate a clinical response earlier in course. Disclosures All Authors: No reported disclosures
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Li, Guichao, Jennifer Y. Wo, Lawrence Scott Blaszkowsky, et al. "Preoperative chemoradiotherapy versus postoperative chemoradiotherapy for local advanced gastric or Siewert II/III GEJ cancer: A retrospective analysis." Journal of Clinical Oncology 36, no. 4_suppl (2018): 115. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.115.
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115 Background: Radiation therapy has improved survival in gastric cancer in some randomized trials. However, post-operative fields have been difficult tolerate, and completion rates have been low. Preoperative therapy may afford the opportunity to radical therapy, and potentially improve the resectability in advanced patients. Methods: Patients with Siewert II/III GE junction or gastric cancer treated at Massachusetts General Hospital were evaluated with Institutional Review Board approval. Clinical parameters and prognostic factors including gender, age, clinical stage, pathological stage, radiation parameters, concurrent chemotherapy, non-radiation chemotherapy, toxicity and survival were included in the analysis. Results: From Jul 2005 to Jan 2017, we enrolled 88 patients had chemoradiotherapy (CRT) and surgery, 48 preoperative and 40 postoperative CRT patients. In the preoperative group, 16.7% (8/48) had nodes outside a standard D2 dissection range, and the pathologic complete regression (pCR) rate was 18.8% (9/48). Median preoperative and postoperative radiation dose was 50.4 Gy and 45 Gy. Two-drug regimen was the most commonly used preoperative concurrent chemotherapy: 60.5% and single drug was the most commonly used postoperative concurrent chemotherapy: 97.5%. Except concurrent chemotherapy, 25 preoperative CRT patients received induction FOLFOX (median 8 cycles); 9 postoperative CRT patients also received 5-FU and 23 received FOLFOX (or EOX) chemotherapy. The estimated 3-year relapse-free survival (RFS) and overall survival (OS) in the preoperative and postoperative group was 51% vs. 34.3% (p = 0.286), and 71.2% vs. 45.9% (p = 0.179), respectively. In preoperative CRT group, there was more hematological toxicity but less gastrointestinal toxicity than postoperative CRT group, more distant metastasis but less peritoneal recurrence rate. Conclusions: Compared to postoperative chemoradiotherapy, preoperative chemoradiotherapy option has the trend of better tolerance, higher RFS and OS in patients with local advanced gastric cancer. Different chemoradiotherapy strategy may lead to different recurrence patterns.
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Kutny, Matthew A., Todd A. Alonzo, Robert B. Gerbing, et al. "Results of a Phase III Trial Including Arsenic Trioxide Consolidation for Pediatric Patients with Acute Promyelocytic Leukemia (APL): A Report from the Children's Oncology Group Study AAML0631." Blood 126, no. 23 (2015): 219. http://dx.doi.org/10.1182/blood.v126.23.219.219.
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Abstract Results from cooperative group trials demonstrating the effectiveness of arsenic trioxide in the treatment of newly diagnosed APL have thus far been restricted to trials consisting of primarily adult patients. The Children's Oncology Group trial AAML0631 incorporated two cycles of arsenic trioxide (ATO) during consolidation with approximately 40% reduction in anthracycline dosing compared to the Italian AIDA0493 trial which has the largest cohort and best phase III results published for pediatric APL (Testi et al Blood 2005). Eligibility criteria included age ≥ 2 to < 22 years, de novo APL confirmed by PML-RARA PCR and no prior therapy. Diagnostic white blood cell count (WBC) determined risk group as standard risk (SR) for WBC < 10,000 and high risk (HR) for WBC ≥ 10,000. ATRA was given at the pediatric dose of 12.5 mg/m2/dose PO BID on days 1-30 of induction and days 1-14 of each consolidation course and each maintenance cycle. Other therapy was as follows: Induction- idarubicin 12 mg/m2/dose for 3 doses; Consolidation 1- 2 cycles of ATO 0.15 mg/kg/day IV 5 days each week for 5 weeks; Consolidation 2- cytarabine 1,000 mg/m2/dose IV q12 hours days 1-3, mitoxantrone 10 mg/m2/dose IV days 3, 4; Consolidation 3- idarubicin 5 mg/m2/dose IV days 1, 3, 5; Consolidation 4 (HR APL only)- cytarabine 1,000 mg/m2/dose IV q12 hours days 1-3, idarubicin 10 mg/m2/dose IV day 4; Maintenance (12 weeks/cycle for 9 cycles)- 6-mercaptopurine 50 mg/m2/day PO, methotrexate 25 mg/m2 PO once weekly. Intrathecal cytarabine was given once during each consolidation 2-4 and cycle 1 of maintenance. Between 3/2009 and 11/2012, 108 patients enrolled and 101 (66 SR and 35 HR) were evaluable for outcome (4 PML-RARA PCR negative, 3 local consent issues). Hematologic CR after induction (without central review) was 81%. The molecular (RQ-PCR) remission rate for those tested at end of Consolidation was 100%. For all patients, overall survival (OS) was 94% and event free survival (EFS) was 92% at 2 years. Comparing SR to HR, the OS was 98% vs. 86% (p=0.004) and EFS was 97% vs. 83% (p=0.014) (Figure 1). The predetermined statistical plan was to compare the EFS results to AIDA0493 which had 2 year EFS of 91% for SR and 79% for HR APL. Relapse risk on AAML0631 from end consolidation I (following ATO treatment) was 2% at 2 years and did not differ significantly between patients with SR vs. HR APL. Events on this trial included 3 relapses, 1 second malignant neoplasm (squamous cell carcinoma in situ) and 7 deaths (6 HR APL, 1 SR APL) including one death post-relapse. Four deaths during induction (all HR APL) included multiple etiologies, but coagulopathy was a factor in each. There were 2 post-induction on-therapy deaths: SR APL patient with accidental (non-chemotherapy) drug overdose during Consolidation 3 and HR APL patient with gram negative sepsis during Consolidation 2. Three relapses included: combined molecular bone marrow (detected by PCR) and CNS relapse in a SR APL patient during maintenance cycle 7 (24 months post diagnosis), combined hematologic bone marrow and CNS relapse in a HR APL patient during maintenance cycle 6 (23 months post diagnosis), and molecular bone marrow relapse in a HR APL patient after therapy completion (38 months post diagnosis) who later died of stem cell transplant complications. Both patients with molecular relapse had low level PML-RARA transcript detection (under 0.001 NCN) during maintenance beginning 1 and 16 months prior to relapse. No other patients had similar "borderline" results. While 28 patients had a diagnostic LP performed in pre-therapy evaluation, 7 patients met the protocol definition of CNS disease (CNS2 N=4, or CNS3 N=3). The 2 patients with relapse involving the CNS did not have CNS disease at diagnosis. Historically, AIDA0493 represents the largest (N=107) and best published outcomes for a major pediatric phase III trial in APL. The current trial of 101 pediatric patients achieved higher EFS rates in both SR and HR APL through incorporation of ATO while significantly reducing anthracycline doses. The reported CR rate was lower than historical comparisons, but this was likely due to difficulty in assessing differentiating and recovering bone marrow cells after APL induction. The excellent molecular remission rate at end of consolidation and the low relapse rate confirm the effectiveness of this therapy. These results strongly support use of ATO in pediatric patients with newly diagnosed APL. Disclosures Off Label Use: Arsenic Trioxide in pediatric patients with newly diagnosed APL. Gemtuzumab Ozogamicin in Pediatric AML..
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Jurkowski, Lauren, Aditya Varnam Shreenivas, Sakti Chakrabarti, et al. "Association of total neoadjuvant therapy with favorable clinical outcomes in patients with locally advanced esophageal and gastroesophageal junction adenocarcinomas (LA-GEJ CA)." Journal of Clinical Oncology 39, no. 3_suppl (2021): 231. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.231.
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231 Background: Both peri-operative chemotherapy and neoadjuvant chemoradiation have been shown to improve outcomes in patients (pts) with LA-GEJ CA compared to surgery alone. Rates of post-operative chemotherapy delivery remain suboptimal. Total neo-adjuvant therapy (TNT) in LA-GEJ CA - induction chemotherapy (IC) followed by concurrent chemoradiation (CRT) - may improve systematic delivery of neoadjuvant therapy and result in favorable clinical outcomes. Methods: We retrospectively reviewed medical records of 135 pts with LA-GEJ CA at our institution between 2/2007 and 11/2019; pertinent clinical data were abstracted with Institutional Review Board approval. Patients treated with IC and curative-intent CRT with ≥40 Gy dose of radiation for adenocarcinoma were included in this analysis (N = 59). Doublet or triplet IC regimens utilizing 5-Flurouracil(5-FU), Cisplatin/Oxaliplatin and Docetaxel were commonly administered while combinations of Carboplatin +Paclitaxel or 5-FU + Oxaliplatin were used in CRT. Clinical complete response (CCR) was defined as metabolic imaging and endoscopic biopsies negative for residual malignancy after completion of TNT. Patients were followed from diagnosis to recurrence and overall survival. Survival probabilities were estimated using the Kaplan-Meier method and compared between groups using a log-rank test. Results: Out of 59 evaluable pts, 69% were clinical stage T3, 71% were node positive. 37 pts (63%) underwent surgery, R0 resection rate was 89% (33/37), pathologic complete response (pCR) rate was 19% (7/37). Among the pts who did not undergo surgery, 41% (9/22) opted to forego surgery since they attained a CCR. For the entire cohort, median Disease-Free Survival (mDFS), median Overall Survival (mOS), and 3-yr OS were 2.4 yrs, 4.7 yrs, and 67% respectively. Pts who did not undergo surgery had a mDFS, mOS, and 3-yr OS of 1.5 yrs, 4.2 yrs, and 59% respectively. Median DFS, mOS, and 3-yr OS of patients who underwent surgery were 3.5 yrs, 5.8 yrs and 72% respectively. Patients who achieved a CCR and opted to forego surgery (N = 9) had a 3 -yr DFS of 42% vs 83% for pts (N = 7) who demonstrated a pCR after curative intent tri-modality therapy. (P = 0.0099) Interestingly, the same group that achieved CCR and opted out of surgery had 3yr OS of 89% vs 83% of those who demonstrated a pCR (p = 0.0042). Conclusions: TNT for pts with LA-GEJ CA is associated with high rates of R0 resection as well as excellent DFS and OS compared to historical controls, warranting prospective evaluation. The remarkable DFS and OS in patients who opted to forego surgery due to achieving CCR is reflective of the local and systemic control rendered by this approach. Careful characterization and close longitudinal follow-up of patients who achieve CCR may help identify a subgroup of LA-GEJ CA pts who may benefit from surgery sparing approaches.
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Chanez, Brice, Jérome Guiramand, Vincent Niziers, et al. "Does radical surgery for gastric cancer after 70 years prolong survival?" Journal of Clinical Oncology 38, no. 15_suppl (2020): e16527-e16527. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16527.
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e16527 Background: Gastric cancer (GC) occurs in 50% of case after 70 years old (y/o). Radical surgery or perioperative treatments have to be balanced with safety management in those potential frail patients. Methods: We perfomed a retrospective review of our single institution database to address the outcome of patient (pts) > 70y/o who underwent radical surgery for GC with or without neoadjuvant and adjuvant treatment. Results: From 2005 to 2019, 60 eligible patients (pts) have undergone radical surgery for resectable GC. Median age at diagnosis was 74.2y/o [70.3-92.8] and 82% were male. Initial echoendoscopy staged 12% of T1/T2 tumor versus 70% of T3/T4, whereas 60% were found with lymph node spreading (N+). 80% of pts were given neoadjuvant treatment: chemoradiation (58%), chemotherapy (45%) or radiation alone (1%). 1/4 pt received perioperative chemotherapy. Only one patient had post-operative radiation with FOLFOX and none had adjuvant radiation alone. Surgery procedure was total (27%) or sub-total (5%) gastrectomy, polar-oesogastrectomy with thoracotomy (18%) or without thoracotomy (50%). Post-operative mortality within 3 months was 5% (n = 3) including 2 pts in the first 30 days. For the global cohort, median overall survival (mOS) was 44.75 months and median progression free survival (mPFS) was 21.2 months. Patients who frontly underwent radical surgery (n = 15, 25%) had small disease with 13% pT0 and 60% of pT1 on final pathology. Only 27% had pT2/T3 but all had vascular and/or peri-nervous emboli. Two of them (13%) were pN+. The mOS was 60 months and mPFS 60 months in this cohort and 33% of pts end/was lost of follow up. Only one metastatic relapse was identifies and no local relapse. Six pts died (40%): 2 in the 30-days post surgery (13%), 3 (30%) from other cause than GC and 1 (7.5%) because of GC distant relapse. The cohort treated with neoadjuvant chemotherapy (n = 45, 75%) was given platinum and anthracycline-based regimen in 73% and 16% of cases, respectively. 1% received fluoropyrimidine +/- irinotecan. 53% associated radiation to neoadjuvant chemotherapy. After neoadjuvant treatment completion, 47% of downstaging (including 18% of pCR), 33% of stable stage and 15.5% of upstaging was observed and 40% of initial usN+ was pN0. After perioperative treatment, mOS was 31 months and mPFS was 18.9 months. Overall 44% experienced local and/or distant relapse. Conclusions: Age above 70y/o should not systematically exclude patient from neoadjuvant or perioperative treatment and radical surgery, which is feasible in selected population displaying long term result in focal and distant disease control.
Books on the topic "Post completion review (PCR)"
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International Federation of Accountants. Financial and Management Accounting Committee. Post completion review. International Federation of Accountants, 1994.
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International Federation of Accountants. Financial and Management Accounting Committee., ed. Post completion review. International Federation of Accountants, 1994.
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Jain, Nityanand, Tungki Pratama Umar, Reem Sayad, et al. "Monkeypox Diagnosis in Clinical Settings: A Comprehensive Review of Best Laboratory Practices." In Advances in Experimental Medicine and Biology. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-57165-7_16.
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AbstractAn outbreak of monkeypox (Mpox) was reported in more than 40 countries in early 2022. Accurate diagnosis of Mpox can be challenging, but history, clinical findings, and laboratory diagnosis can establish the diagnosis. The pre-analytic phase of testing includes collecting, storing, and transporting specimens. It is advised to swab the lesion site with virus transport medium (VTM) containing Dacron or polyester flock swabs from two different sites. Blood, urine, and semen samples may also be used. Timely sampling is necessary to obtain a sufficient amount of virus or antibodies. The analytical phase of infectious disease control involves diagnostic tools to determine the presence of the virus. While polymerase chain reaction (PCR) is the gold standard for detecting Mpox, genome sequencing is for identifying new or modified viruses. As a complement to these methods, isothermal amplification methods have been designed. ELISAassays are also available for the determination of antibodies. Electron microscopy is another effective diagnostic method for tissue identification of the virus. Wastewater fingerprinting provides some of the most effective diagnostic methods for virus identification at the community level. The advantages and disadvantages of these methods are further discussed. Post-analytic phase requires proper interpretation of test results and the preparation of accurate patient reports that include relevant medical history, clinical guidelines, and recommendations for follow-up testing or treatment.
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Orazova, Aknur, and Aliya Kuzhabekova. "Women’s Experiences in Education in Turkmenistan." In Palgrave Studies in Gender and Education. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-75301-5_11.
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Abstract This paper explores the experiences of women in education in the Central Asian country of Turkmenistan. The exploration is based on the review of the relevant policies, reports, statistics, and scholarly research, as well as on the data from written accounts of women who had experiences in the education system of the country. We first provide a quick overview of the situation with gender equality generally and in education more specifically during the Soviet and post-Soviet periods. We then use data from the written accounts to explore in greater detail the unique experiences of women in education and the way the experiences are shaped by a variety of cultural and societal beliefs. The primary criteria of eligibility for participation in the written accounts was being a woman holding at least a certificate of completion of secondary education in Turkmenistan. The common themes emerging from the participants’ insights included the various challenges faced by women in education, the pervasive family influence, and the irreconcilable differentiation between what is considered masculine and feminine behaviors. In addition, we revealed the women’s awareness about their agency and the importance of empowerment.
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Petrucci, Anna Laura. "Resilience in Practice: The Identity-Based Resilience of the Diplomatic Quarter in Riyadh." In Contributions to Economics. Springer Nature Switzerland, 2024. https://doi.org/10.1007/978-3-031-73090-0_17.
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AbstractThe concept of resilience is often defined in a variety of ways, depending on the specific context or field of study. For instance, in a review of resilience definitions, particularly in the context of disaster recovery, Plodinec (2009) identifies over 40 distinct definitions. Viewing cities as complex adaptive systems, and breaking them down into components and analytical elements, can facilitate the process of enhancing resilience through urban system design, planning, and management. Both physical and social processes can be seen as spatial and temporal interactions across networks, and it is the movement into, out of, and within cities that is of utmost importance for promoting beneficial operations and suppressing harmful ones. Understanding the vulnerable network components of cities, how these components enable specific interactions, and the ability to design various elements and their interactions to achieve resilience, is a complex and nuanced task.Most of the current literature is, as a matter of fact, about post-disaster recovery, while the main goal of resilience, to be sustainable, is to plan in advance, limit or prevent disasters, not measure the time of bouncing back from it. This belief made it worth searching and analyzing case studies, making a positive impact despite the difficult conditions and making these learned lessons for future cities. Like sustainability, Resilience is an abstract and extensive concept, making it difficult to determine a specific implementation plan if it is not fully site-specific. Building a capacity for Resilience is a complex and multifaceted task, considering the myriad components, processes, and interactions within and beyond a city’s boundaries. And what if the conditions of the contest are unprecedented and the most challenging due to climate, time, and management constraints? Only time can tell. That’s why, after 45 years of completion, the resilience potential embedded in the planning process of the Diplomatic Quarter in Riyadh can offer assessing elements of Resilience and the potential of its applied solutions on their positive impact in the long term.
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"Post-completion review and in use." In Code of Practice for Project Management for Construction and Development. John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118378168.ch8.
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"Post-Completion Review/Project Close-Out Report Stage." In Code of Practice for Project Management for Construction and Development. Blackwell Publishing, 2008. http://dx.doi.org/10.1002/9780470773710.ch8.
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Ahmed, Andaleeb A. "Coronary Artery Bypass Procedures." In Advanced Anesthesia Review, edited by Alaa Abd-Elsayed. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/med/9780197584521.003.0116.
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Abstract Coronary artery bypass grafting (CABG) is indicated for chronic stable angina with high-risk coronary disease; unstable angina; post–myocardial infarction angina; and ischemia on noninvasive testing. CABG remains the mainstay for many patients with multivessel disease. The anatomical complexity of CAD, predicted surgical mortality, and anticipated completion of revascularization are some of the crucial factors in deciding revascularization strategy. Standard CABG is performed through a median sternotomy incision and involves the institution of cardiopulmonary bypass (CPB). Vascular conduits like the saphenous vein, internal thoracic artery, and radial artery are grafted between the ascending aorta and coronary artery distal to its obstruction. In addition to on-pump CABG, off-pump CABG (OPCAB), minimally invasive direct CABG (MIDCAB) robotic, and hybrid revascularization strategies are increasingly being used.
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"The Development and Growth of Professional Coaching as an Education Retention Strategy." In Coaching for Student Retention and Success at the Postsecondary Level. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-5948-1.ch001.
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This chapter develops background, data points, research, and literature review context around the factors and the educational environment that led to the identification of processional coaching as a promising retention strategy at post-secondary institutions. The chapter begins with some background on the history of educational coaching and how it was initially defined and then chronicles the development of professional coaching as an educational retention strategy. The chapter briefly discusses the financial impact of low retention both from a student and an institutional perspective. The chapter then looks at graduation rates by institution and surveys online versus face-to-face graduation rates and the growth of online learning and its impact on student retention. There is exploration of how for-profit institutions and their growth created a conducive environment for the design and deployment of professional coaching in the higher education sector. The chapter also investigates how increased participation in higher education led to lower completion rates and how this dynamic eventually led to the development of new and innovative strategies around retention. Some background on the birth and ascension of online degree completion programs also helps to set the stage for later research related to retention and student success and how non-first-time students as the new majority are impacting the post-secondary education marketplace. Learning and motivation challenges for non-first-time students are also introduced and explored within the context of the development of coaching as a retention strategy.
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Ouelfatmi, Meryem, Sadik Madani Alaoui, and Jacquelynne Anne Boivin. "Technology's Role in Enhancing Female Higher Education Access and Experience Across the MENA Region." In Advances in Higher Education and Professional Development. IGI Global, 2024. http://dx.doi.org/10.4018/979-8-3693-3904-6.ch008.
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Women's education has a history on a global scale of being marked by struggle, strife, persistence, progress, and more. The Middle East and North Africa (MENA) countries are no exception. This chapter addresses the status of women's education varies by country, but and while “progress” can describe the status in each MENA country, each nation has areas that warrant attention for future improvement. Higher education, specifically, is a level that warrants attention due to its societal impact for women. This review of the literature provides an overview of the status of women's higher education in a variety of MENA countries and summarizes the major gains that each country has taken for women's post-secondary education and what areas of improvement need to be addressed. The role that technology has played and can play in the future will be emphasized. By exploring these ideas, the goal is for readers to consider future research that can help ignite next steps in policies and structures that can promote women's access to higher education and completion of post-secondary degrees.
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Betts, Michael J., Laura Eshelby, and David Whitehouse-Hayes. "Fraud Investigation Fundamentals." In Blackstone's Counter Fraud Professionals' Handbook. Oxford University PressOxford, 2024. http://dx.doi.org/10.1093/9780191996955.003.0008.
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Abstract This chapter introduces the basics of effective investigation including how to plan, lead, and evaluate following the completion of an investigation (post-investigation review). The reader is provided with key approaches for all stages of investigation, and insight into how to manage a range of varying complexities in doing so, including multidisciplinary and multi-agency investigations. It provides a guide to key products and tools to adopt in the pursuit of investigation. It explains the use of techniques and models that will help support consistent-quality investigation outcomes, and also assist with the consolidation of learning and knowledge for the reader. The chapter includes an overview of key challenges and risks to look for and manage in the pursuit of investigation, drawing on personal insight from those with substantial experience in law enforcement and public sector investigations and fraud response. Content is linked to the Government Counter Fraud Profession Standard on investigation and incorporates a review of the basics that underpin the investigative mindset, including decision-making, material attrition, and how to follow the money in a fraud investigation. It has wide applicability in terms of operating environments, and explores the frameworks for regulatory, civil, and criminal investigations.
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Mayavo, Crossman. "Public-Private Partnerships for Sustainability in the Context of Zimbabwe." In Advances in Logistics, Operations, and Management Science. IGI Global, 2024. https://doi.org/10.4018/979-8-3693-5912-9.ch014.
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Public Private Partnerships have become the cornerstones of most developed and developing countries, and Zimbabwe is not an exception as they are flagship PPPs that have stood the test of time. The country could benefit so much from the use of public private partnerships as a means of sustainable development. The objectives were to investigate how the PPPs can contribute to sustainability in Zimbabwe showcasing the possibilities, obstacles, and future directions for effective public and private cooperation. The study made use of a qualitative study using document review method. The rationale behind using these companies is that they have PPPs running or completed and the authors looked at what contributions were made and what are the effects. The results showed that PPPs can be a source of sustainability in Zimbabwe as witnessed by the completion of Beitbridge Border Post, road rehabilitation and other running PPPs such as the Airport of Zimbabwe. Barriers such as political, economic and social can be solved and the country remain sustainable.
Conference papers on the topic "Post completion review (PCR)"
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AlSaad, Mohammed, and Imad Brohi. "Productivity Comparison of Different Completion & Stimulation Strategies with Underbalanced Coiled Tubing Drilling in Gas Carbonate Reservoirs." In SPE/IADC Managed Pressure Drilling and Underbalanced Operations Conference and Exhibition. SPE, 2024. http://dx.doi.org/10.2118/221445-ms.
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Abstract Gas condensate reservoirs often require special completion and stimulation techniques to maximize productivity. Workovers performed due to well integrity issues often lead to formation damage which can severely impact the production potential from these wells. Some of the most commonly used well completion techniques are conventionally stimulated vertical wells, Multi-Stage Fracturing (MSF) with ball drop systems or plug and perf systems. More recently, these completion systems have been challenged by Underbalanced Coiled Tubing Drilling (UBCTD), which has proven to yield high. This paper aims to compare the post-completion production performance achieved with these completion techniques with special emphasis on UBCTD while factoring in reservoir characteristics that contribute to such results. Furthermore, to thoroughly assess the productivity index associated with each well type, an extensive review was conducted on the advantages and limitations of UBCTD, MSF wells, and conventionally stimulated vertical wells. The review focused on the various factors that influence productivity, such as relative comparison of reservoir properties, wellbore stability, drilling fluid selection, and completion techniques. This paper introduces a novel integrated approach to evaluate the PI of gas wells drilled using UBCTD technology, MSF wells, and conventionally stimulated vertical wells. Specialized plots were developed which helped in comparative assessment of the different completion types and also understand the differences. The proposed method combines the analysis of normalized field data, numerical simulation and a comprehensive review, offering a more reliable and accurate assessment of well productivity and the reasoning behind exhibited results. Furthermore, the paper highlights the importance of considering various factors, such as drilling fluid selection, and completion techniques, in optimizing the PI of gas wells. This study provides valuable insights for reservoir engineers, drilling engineers, and decision-makers in selecting the optimal well configuration and drilling technology to maximize hydrocarbon production.
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Kalyani, Tejas, Haavard Aakre, and Vidar Mathiesen. "The Autonomous Inflow Control Valve Design and Evaluation Criteria Along with Well Performance Review for Multiple Installations Across the Globe." In Offshore Technology Conference. OTC, 2021. http://dx.doi.org/10.4043/31193-ms.
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Abstract Many wells across the globe have been installed with Inflow Control Device (ICD) technology to balance the production across the production interval, addressing some of the challenges associated with horizontal and deviated wells. Nevertheless, ICDs have limitations with restricting unwanted fluids upon breakthrough. Autonomous Inflow Control Valve (AICV) technology functions similar to an ICD initially (i.e., balancing flux across the length of horizontal wells, effectively delaying breakthrough) but provides the additional benefit of shutting off the flow of unwanted fluids upon breakthrough. This paper will present comprehensive AICV completion design workflow along with multiple case histories highlighting the reservoir management benefits of the AICV technology in mitigating un-wanted inflow of water and gas and delivering improved oil production and recovery. Like other AICDs (Autonomous Inflow Control Device), AICV can differentiate the fluid flowing through it via fluid properties such as viscosity and density at reservoir conditions. However, AICV's performance is much more effective due to its advanced design which provides further benefits using both Hagen-Poiseuille's and Bernoulli's principles. AICV technology is based on the difference in the pressure drop in a laminar flow element (LFE) compared to a turbulent flow element (TFE) and has a capability to shut-off the main flow autonomously when an unwanted fluid such as water or gas breakthrough occurs. Thus, reduces well water cut (WC) and/or gas-oil ratio (GOR) significantly. Rigorous single-phase and multiphase flow-loop tests have been conducted covering a wide range of fluid properties to characterize the AICVs flow performance. Extensive plugging testing and accelerated erosion tests have also been conducted. This paper presents some of these flow performance analysis and testing results. Furthermore, the paper will also discuss in detail a reservoir-centric AICV completion modelling and design workflow. Finally, this papers also discuss in detail AICV well performance installed in a light oil as well as in heavy oil reservoirs and how operators achieved higher OPEX saving as well as higher ultimate recovery (UR) from the wells due to prolonged as well as significant reduction in water cut and/or lower GOR. The AICV design methodology and performance evaluation analysis is presented through several case studies. The analysis takes into account the whole cycle: from flow loop testing to characterization, reservoir modelling, optimized AICV completion design and post-installation well performance to evaluate the AICV technology benefits.
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Lawrence, Matthew, and Ahmed Attia. "Comparing and Combining Camera, Tracer and Distributed Temperature and Acoustic Sensing DAS+DTS for a Holistic Understanding of Stimulation and Production Performance." In SPE Hydraulic Fracturing Technology Conference and Exhibition. SPE, 2021. http://dx.doi.org/10.2118/204188-ms.
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Abstract In the present cost-constrained environment, it is critical that operators effectively complete their wells while minimizing capital expenditure. Optimization efforts focus on increasing recovery factor by managing landing zone, increasing the number of effective fractures, increasing the size of the fractures, and increasing the length of the lateral, while reducing the total number of stages and job size, without sacrificing efficient proppant and fluid delivery. The same pressure to reduce expenditure also impacts decision making on diagnostic evaluation, reducing operators to ‘free’ or low-cost feedback, like surface production rates and decline curves. Operators are responding to these challenges by utilizing a combination of lower cost, post-completion diagnostics like deployed fiber optics, downhole camera evaluation of perforations and radioactive tracers. These less expensive options allow for a broader scope and number of diagnostic inquiries, whereas a permanent fiber may prove to be cost-prohibitive, reducing diagnostic focus to one well, in one part of a play. Combining differing diagnostic technologies enhances the overall description of the well and reservoir behaviors and improves confidence in their interpretation of stimulation and production efficiency; furthermore, where a single diagnostic measurement may be unlikely to justify dramatic change in a completion strategy, a combination of data points from different domains can and does support design change that leads to rapid, real world performance improvements. Care is needed in the conclusions drawn when utilizing complimentary diagnostics due to the differences in depth of investigation and the non-unique interpretation of some data types. This paper discusses three post-completion diagnostic technologies, perforation evaluation by downhole camera, radioactive tracers, and distributed acoustic and temperature sensing (DAS+DTS) data and their respective physical measurements, strengths and weaknesses and how they can be combined to better understand well and reservoir behavior. It concludes with a review of completion optimization efforts from the Rockies area, where these post-completion diagnostic technologies were applied in the evaluation of eXtreme Limited Entry (XLE) trials. A statistical analysis of the RA tracer, downhole camera measurement of perforation area and deployed fiber optic acquisition of DAS+DTS reveals no correlation between diagnostic answers, indicating no one diagnostic measurement can accurately predict the other, such that it could substitute for that diagnostic and provide the same answer. Asking the right question can often enhance the value of diagnostic descriptions of the system in question. Those answers often lead to the next question and clear the path forward in advancing completion optimization. Complimentary diagnostics facilitate a more complete understanding of stimulation and production performance when compared, increasing confidence when they agree. When one or more appear to disagree, the different respective physical measurements and depths of investigation often reveal a more complete and complex understanding of stimulation and production efficiency. As an aggregate they provide clarity on the effect of efforts to create conductive pathways into the reservoir, allowing operators increased control over the resulting production.
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Alabdullah, Mohammed, Pedro Correa, and Ali Baghanim. "De-Completion Optimization by Feed Through Production Packer Retrieval with Coiled Tubing." In SPE/ICoTA Well Intervention Conference and Exhibition. SPE, 2025. https://doi.org/10.2118/224073-ms.
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Abstract This paper details the successful application of 2.375-in coiled tubing (CT) for challenging retrieval of production packers in smart completion well, designed with a shift-to-release mechanism, after five years of being set in an offshore oil producer. Will review the methodology followed for equipment selection and best practices, to accomplish packer manipulation efficiently while reducing runs, equipment required, minimizing risks, maintain well integrity and considerably optimizing operational time and financial impact to the intervention. Critical factors for the shifting of the packers were the CT string configuration, well conditioning and BHA. Considering that the core of the intervention depended not only on the ability to deliver shifting force (28-klbf) to packers set at depths with ~35-degree and ~85-degree, but also the ability to apply higher shifting force (42-klbf) to activate the emergency release mechanism as contingency. Use of impact tools in the BHA was not feasible, due to potential risks of damaging the profile, shifting tool and unintentional activation of emergency release mechanism. The deployment of a suitable CT string resulted in a successful shifting of two packers installed in the smart well completion of an offshore well. Key observations during the operation indicated that CT performance matched the simulations performed with proprietary engineering software. It provided sufficient force in a secured and adequate form to manipulate the production packer mechanism into its release position. The results showed that the combined application of this packer type and proper CT string, not only reduced the operational time and rig cost, but also minimized the risk of mechanical failure. Furthermore, well integrity was maintained throughout the process, and post-operation evaluation confirmed the effectiveness of the production packer shifting utilizing CT and shifting tool selection. Moreover, the contingency plan in case of unsuccessful packers shifting operation with CT, is to cut tubing with wireline and fish the packers with drill pipe. The utilization of CT in workover interventions is extremely beneficial, due to its versatility. This paper presents an innovative operational procedure that is superior in comparison of utilizing different packer types and interventions with Slickline, Wireline or Drill-pipe. This approach results in decreased requirement of services, saving cost and minimizing risk to the Operator for de-completion of offshore smart wells.
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Dani, C. "Successful Water Shut-Off Utilizing Lower Completion ICD+SSD – Actual Case Study of Marginal Oil Field of Onshore UAE." In ADIPEC. SPE, 2024. http://dx.doi.org/10.2118/223041-ms.
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Abstract Marginal oil fields often experience critical and challenging periods to sustain oil rates above minimum economic thresholds. Mitigative measures such as installation of lower completions (LC) help to control water production (water shut-off) and sustain oil production. In SPE-211320-MS, clear definition of data driven based candidate screening process for LC was discussed in detail. This paper will elaborate actual examples on LC design, post LC installation evaluation and describe several key factors to be considered when designing the LC implementation. In addition, well performance-based metrics will be highlighted to showcase the success of water shut-off (WSO) utilizing the LC implementation. It is critical to collect key data prior to preparing the LC design, which will ultimately impact the success of the LC implementation. Fresh production logging data and available open hole logs should be appropriately mapped and placed on the same page to analyze any information supporting the LC design. A collaborative review amongst petroleum engineers, Petro-physicists and other disciplines is necessary to understand and agree on the final data to be used for the design. Subsequently, the LC simulation designs should attempt to match the current well conditions and production. The simulations should involve testing sensitivities with different ICD+SSD settings and locations to obtain the best and most suitable results. A favorable outcome from this work should be to reduce water cut as much as possible from the original performance. Post LC installation, well production performance will be reviewed to assess the effectiveness of the LC configuration to achieve the targeted water cut. If necessary, production logging will be run to confirm that all LC elements are functioning as per the design. Before implementing the LC, four (4) wells were tested for installing ESP (Electric Submersible Pump) without LC. The results were unexpectedly negative, with WC increasing to 60-80% within two months. This trial will serve as a baseline for reviewing the success of LC implementation. Up to date, LC has been deployed in 28 wells and the results were evaluated based on WC reduction, improved accessibility, and LC equipment functionality. The post-LC installation results were impressive and key findings were gathered to improve the LC design. Three (3) wells with successful water shut-off will be presented in this paper. There have been many lessons learned and derived best practices of LC implementation from this study. This success of water shut-off could copied to other Field in similar reservoir condition. Moreover, guidelines, best practices and documentation have been developed for both internal future marginal field developments and could be leveraged for other oilfield operators to plan successful water shut-off attempt.
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McNamee, Rianna. "Unplanned Pregnancy as an Independent Risk Factor for Antepartum SI in a Post Roe vs. Wade World." In 28th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2024. https://doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.2_2024.
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Abstract: The objective of this literature review is to determine whether unplanned pregnancy is an independent risk factor for developing antepartum SI. Background: The Supreme Court of the United States of America recently ruled that the constitution of the United States does not confer a right to abortion to its citizens. As of October 2023, twenty-one states had developed full or partial bans on abortion, resulting in millions of Americans residing in areas where terminating unplanned pregnancy is not a viable option. There is evidence that indicates antepartum suicidal ideation (SI) is higher than that of the general population, however the rate of completion of antepartum suicide is lower than that of the general population. Risk factors for antepartum SI are important to identify for early intervention, and it is now more vital than ever to understand how the U.S.’s reproductive health landscape may contribute to these risk factors. Methods: This literature review utilized the databases PubMed, and PsycINFO as queries for primary data. Inclusion criteria included written in the English language, peer-reviewed, methodology of cross-sectional or longitudinal study design, and published between 2003 and 2023. Studies were excluded based on relevance, with articles focused on postpartum SI/depression, suicidal action/self-harm, and antepartum SI associated with specific medical conditions/medications excluded. Results: A total of 6 studies were included in this literature review with incidence rates of antepartum SI ranging from 1.3% to 27.8%. Independent risk factors for antepartum SI that were identified across multiple studies were: history of depression or other psychiatric disorders; partner violence or marital problems; and belonging to a racial or ethnic minority. Unplanned pregnancy failed to be established as an independent risk factor for antepartum SI. Discussion: While unplanned pregnancy was not found to be an independent risk factor in this study, it has the potential to contribute to likelihood of developing antepartum SI in patients with already established independent risk factors. The major limitation of this study was the lack of literature regarding the risk of developing SI during pregnancy and relating that risk to unplanned pregnancy, as well as the lack of literature conducted after the Dobbs vs. Jackson Women’s Health decision. As the Dobbs vs. Jackson Women’s Health decision affects more pregnant Americans, it is important that we continue to monitor our pregnant patients for signs and symptoms of SI and to continue to examine potential risk factors.
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Santórum, Marco, Mayra Carrión, Patricia Acosta-Vargas, et al. "A Digital Platform for Respiratory Rehabilitation in Patients with post-COVID19: Design and Usability Evaluation." In AHFE 2023 Hawaii Edition. AHFE International, 2023. http://dx.doi.org/10.54941/ahfe1004289.
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This article presents the outcome of creating a usable digital platform for therapeutic education in respiratory rehabilitation. The platform has been developed to address the growing need for remote rehabilitation services, particularly in the context of respiratory conditions following COVID-19. It provides therapeutic education and supports self-rehabilitation sessions, catering to the needs of patients while also assisting in the training and education of healthcare professionals and students in the field of respiratory rehabilitation.The design process followed a user-centered approach, incorporating inputs from rehabilitation therapy experts and collaborative meetings with representatives from educational institutions. Through a comprehensive analysis of requirements, the platform's functionalities were defined, resulting in a set of clear and precise functional and non-functional requirements. The platform was designed as a progressive web application (PWA) with responsive design for compatibility across multiple devices. It incorporates informative error messages and robust data encryption for user security.The platform consists of different modules: one for users or patients conducting self-rehabilitation, medical specialists and/or students, organization administrators, and the platform administrator. Each module offers specific functionalities tailored to the respective users' needs. Patients can register, access therapeutic educational materials, perform rehabilitation exercises, and track their progress. Medical specialists and students have tools to review and edit patient records, create rehabilitation plans, and monitor their progress. Organization administrators can manage users and evaluate platform usage, while the platform administrator oversees system management, parameterization, and maintenance.The platform's interface design emphasizes simplicity, effectiveness, and ease of use. Patients can easily navigate through welcome screens, access rehabilitation plans, view exercise videos, and generate progress reports. Medical specialists and students have intuitive interfaces to create rehabilitation plans, add new exercises, review patient records, and access comprehensive reports for monitoring progress. Multimedia elements, including videos, enhance the effectiveness of rehabilitation exercises.The platform's data model effectively captures information about organizations, patients, medical specialists, exercises, and evaluations. The navigation model facilitates intuitive interaction and efficient task completion. In addition to the design, this article also presents the implementation of usability testing.To evaluate the platform's usability, a protocol proposed by Abhay Rautela was followed, accompanied by the use of the Computer System Usability Questionnaire (CSUQ). The evaluation involved a group of participants who performed tasks relevant to their roles as physiatrists or patients. The CSUQ was used to collect feedback and assess user satisfaction. The results of the usability evaluation will be discussed, providing insights into the platform's strengths and areas for improvement.
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Shah, Vrushank. "Review of Missing Data Elements for Client Enrollment in the Minority AIDS Initiative for High-Risk Men of NJ." In 28th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2024. http://dx.doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.119_2024.
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The Minority AIDS Initiative study funded in NMI seeks to enhance healthcare outcomes for underserved individuals. Implementing outreach programs, the initiative provides healthcare and post-treatment follow-up to this demographic. The proposed project, a component of this study, concentrates on individuals with substance abuse disorder, specifically targeting those who have been onboarded but subsequently lost to follow-up. In the United States, approximately 20 million people are diagnosed with substance abuse disorder, yet in 2016, only 3.8 million received treatment. Within this cohort, between 20% and 70% of individuals undergoing residential substance abuse treatment disengage before completion. Various factors hinder the sustained retention of individuals with substance abuse disorder (SUD), encompassing biopsychosocial requirements like stable housing and employment, alongside strategies for long-term abstinence.1 Additionally, there's a deficiency in incentives for continuous care, both economically and socially, exacerbating challenges for patients lacking robust social support or financial stability.2 A study by the U.S. Veterans Administration revealed a disparity between the perceived necessity for extended treatment and its implementation, with only 62% attempting to adhere to this recommendation.3 Particularly in minority communities, like African Americans and Latinos, higher rates of premature treatment discontinuation underscore the imperative for deeper investigations into contributing factors, including the potential influence of untreated co-occurring mental health conditions such as depression and anxiety.4, 5 Given these complexities, further research is indispensable to comprehensively grasp the reasons behind patient attrition in SUD treatment, necessitating an exploration of various socio-economic elements within this context.
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Urbina, Arias, Rommel Ernesto, Awad Alenezi, Ahmed Saber, and Kareem Mahfouz. "Successful Installation of a New 15K Multistage Frac (MSF) Completion in a Challenging Extended Reach Lateral HPHT Gas Well." In SPE Conference at Oman Petroleum & Energy Show. SPE, 2025. https://doi.org/10.2118/224892-ms.
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Abstract The methodology described in this paper represented permits to introduce a new open-hole 15K multistage frac (MSF) completion solution in a challenging gas well environment, like high dog-leg severity (DLS) range, washed out boreholes, tight spots and extreme differential pressures between intervals. All started with extensive testing to validate the design, followed by exhaustive job planning, execution, post job and performance review phases. A novel, slim and compact open-hole (OH) mechanical packer was validated to API 19OH-V1 standards and rigorously tested to additional customer requirements. This packer was part of the OH MSF system, which also includes frac sleeves, a unique V0 metal-to-metal seal expandable liner hanger and upper completion, including 15K V0 PBA validated to API 19 AC and stroked up to 2,000 ft in the presence of gas for validation testing. Multiple offsets well data analysis, torque and drag (T&D) modeling, diverse simulations, evaluation and proper execution of the completion installation assisted in minimizing the operational risks during deployment. This OH MSF system was capable of handling extreme downhole environments, in addition to the 15K acid stimulation cycles and gas production phase. The 15K OH MSF solution was comprised of one (1) V0 metal-to-metal seal expandable liner hanger, eleven (11) compact and slim OH mechanical packers, two (2) OH anchors, eight (8) ball-activated frac ports, and one (1) hydraulic toe initiation valve. This completion system successfully withstood multiple ream down events to pass various tight spots through the long lateral. The V0 metal-to-metal seal expandable liner hanger was set inside the 7" parent casing. The lower completion was tied back to surface with the upper completion polished bore assembly (PBA). Acid stimulation was performed rigless after the successful deployment of the MSF completion system. The 15K OH MSF completion, despite the severe mechanical constraints suffered during the deployment phase, withstood ultra-high-pressure cycles exceeding more than a 10,000-psi differential pressure in all the eight frac stages. More than 15,000 barrels of fluid treatment with acid were injected through the completion system. The rig and rigless operations demonstrated the high performance and efficiency of the new system to reach target depth, provide zonal isolation in a very tight formation, and performed in acid environment with high-pressure cycles. The new completion system allowed all operational steps to be performed on the well with high operational efficiency. The slim design and short length of the single element OH mechanical packer enabled the drilling team to reduce the stiffness of the lower completion string. The capability of high anti pre-set resistance to mechanical loads allowed the team to overcome high friction and drag experienced in the extended-reach lateral. The rotational capability of the new OH mechanical packer allowed the completion string to pass through multiple tight spots encountered in the well, and successfully displayed extreme ream-down capabilities. The OH packer exhibited the capability of achieving high-pressure circulation rates. The MSF completion system also demonstrated repeatability of isolation performance during the eight high-pressure acid stimulation stages, overcoming high washouts areas and thereby enhancing stimulation efficiency.
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Paulus, Steven Leonardus, Hendry Shen, and Hany Ahmed Beeh. "Becoming an HPHT World Class Project, the Valemon experience 2012-2017." In SPE/IADC International Drilling Conference and Exhibition. SPE, 2023. http://dx.doi.org/10.2118/212448-ms.
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Abstract The objective of this case study is to share essential learnings from the planning and execution of the first drilling and completion campaign in the Valemon field throughout the period of 2012-2017 with a total delivery of 17 wells. The case study will give an overview of the Valemon field, geology of the area and well design. The development of well trajectory became longer and more challenging as the geology targets moved farther away from the platform. Several major challenges and learnings were experienced during execution such as enabling one run strategy in 17-1/2" section, updating well path strategy to improve borehole stability, managing overburden gas responses in 12-1/4" section, and section target depth strategy for 12-1/4" section. Continuous learnings from sessions such as Improve Well on Paper (IWOP), Drill Well on Paper (DWOP), Subsurface Action Review (SAR), Subsurface After-Action Review (SAAR), operational procedures after action review, experience reports, and post well meetings enabled the project to reduce the time and cost per well. It took 160, 111, and 166 days respectively to complete the first three wells. The last well was delivered in 62 days. By the end of the campaign in November 2017, the Valemon project delivered four (4) extra wells compared to the original plan of thirteen (13) wells, while spending 500 million NOK-2017 (Norwegian Kroner with 2017 currency) or 60 million USD-2017 (United States Dollar with 2017 currency) less than the planned budget. Moreover, the entire drilling campaign was completed without any well control incidents.
Reports on the topic "Post completion review (PCR)"
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Gonzalez Diez, Verónica M., Nayda Ávalos, Ana María Linares, et al. IDB and IIC Project Performance: OVE’s Review of 2016 Project Completion Reports and Expanded Supervision Reports. Inter-American Development Bank, 2017. http://dx.doi.org/10.18235/0010686.
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Assessing the results of individual development operations is essential to learning what works and what does not and thus to increasing the effectiveness of investments in development. The purpose of this independent review is to ensure the accuracy and credibility of the project performance reporting system. This report summarizes the results and findings of OVE’s review of the 30 Expanded Supervision Reports (XSRs) completed by IIC in 2016 for NSG operations that reached early operating maturity in 2015, and for the 21 Project Completion Reports (PCRs) that IDB completed under the 2014 PCR guidelines by the end of 2016.
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Smyth, Emer, Garance Hingre, and Merike Darmody. The School Completion Programme revisited. ESRI, 2024. https://doi.org/10.26504/rs197.
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The School Completion Programme was established in 2002 to provide support for children and young people at risk of early school leaving and is part of a suite of supports offered through the Delivering Equality of Opportunity in Schools (DEIS)1 programme. The programme is run by Tusla Education Support Service (TESS) with oversight from the Department of Education. The programme is organised into 121 projects managed by a coordinator and overseen by a Local Management Committee (LMC). Each project covers a number of primary and post-primary schools. The programme currently covers 783 schools that have a total population of over 250,000 students. The three core outcomes of the programme are improved attendance, improved participation (engagement in learning and other school activities) and improved retention among children and young people, with improved participation seen as leading to increases in attendance and retention levels. To achieve these objectives, there are three levels of intervention: the target group, children and young people identified with the greatest need to whom staff provide more intensive support; brief interventions, designed to address a temporary crisis; and universal interventions that provide whole-class support, for example through a life skills programme. The strands of support are divided between in-school supports, supports around the school day (before or after school, or at lunchtime), holiday provision and supports for young people who are out of school (because of school avoidance, suspension/expulsion, or early school leaving). A review of the programme conducted by the ESRI in 2015 highlighted its value in providing flexible and needs-based supports to vulnerable children and young people. However, the review highlighted a number of challenges, including project governance, variation in the size of projects and the supports provided, and the impact of austerity-related funding decreases. In the intervening period, there have been a number of changes to the programme, including an increase in funding, the introduction of a new intake framework to refer students, a greater emphasis on evidence-based programmes (such as Decider Life Skills and Working Things Out), a roll-out of continuous professional development for staff and webinars for LMC members. There have also been considerable changes in the broader societal context, with the impact of the pandemic on wellbeing leading to marked increases in school non-attendance. This report draws on a survey of SCP coordinators, detailed case studies of six projects, and a consultation event conducted with SCP coordinators and project workers. This rich information is used to examine the operation of SCP in this changed landscape and highlight the implications for future development of the programme.
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GUI, ZHEN, Yue-Ying WANG, Jia-Xin Li, and Tao XIANG. Prevalence of poor sleep quality in COVID-19 patients: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.2.0121.
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Review question / Objective: The inclusion criteria for this study are based on the PICOS acronym: Participants (P): COVID-19 patients based on positive Coronavirus RT-PCR (reverse transcription-polymerase chain reaction) of nasopharyngeal and oropharyngeal swabs or a history of COVID-19 infection. Following previous research, the COVID-19 patients in this study will include the period of COVID-19 infection, symptom onset, recovery, and the onset of post-acute COVID-19 symptoms. Interventions (I): not applicable; Comparisons (C): healthy controls in comparative studies, or not applicable to epidemiological surveys; Outcome (O): the prevalence of poor sleep quality (PSQ) or available data could yield the prevalence of PSQ in COVID-19 patients. Sleep quality in COVID-19 patients will be assessed using standardized scales such as the Pittsburgh Sleep Quality Index (PSQI); Study design (S): epidemiological and comparative studies (only the baseline data of cohort study will be extracted).
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Bouillon, César P., Pablo Fleiss, Roxana Pedraglio, Gunnar Gotz, Luis Fernando Corrales, and Andreia Barcellos. Technical Note: Policy-Based Lending at the IDB. Inter-American Development Bank, 2024. http://dx.doi.org/10.18235/0012925.
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This note presents findings and insights from different sources and constitutes the first building block for the Office of Evaluation and Oversights (OVE) policy-based lending evaluation. Prior evaluation work by OVE and the evaluation departments of other Multilateral Development Banks (MDBs), as well as Inter-American Development Bank's (IDB) project databases, provide a rich source of information on the use and characteristics of policy-based lending. This paper synthesizes findings and insights from: (i) OVE's 2015 review of the design and use of policy-based lending (document RE-485-6); (ii) OVE's 2020 Lending instruments study (document RE-549); (iii) OVE's review of the demand and performance of policy-based lending in its country products (Country Program Evaluations or CPEs, Extended Country Program Evaluations or XCPE, and Independent Country Program Reviews or ICPR); (iv) OVE's validations of IDB's self evaluations of completed operations (project completion report or PCR); (v) the proceedings of a 2020 conference describing the experience with policy-based lending at the Asian Development Bank (ADB), African Development Bank (AfDB), and the World Bank (WB); and (vi) a portfolio analysis of policy-based operations approved up to December 2022.
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Peña-Habib, Oliver, Jorge Gallego, Luis Fernando Corrales, et al. IDB Group Project Performance: The 2023 Validation Cycle. Inter-American Development Bank, 2024. http://dx.doi.org/10.18235/0012862.
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This report summarizes the 2023 results of the Office of Evaluation and Oversight's (OVE's) annual review of project performance at the Inter-American Development Bank (IDB) Group. Every year, IDB Group Management prepares self-evaluations on the final results of its operations. These are called Project Completion Reports (PCRs) at the IDB and Expanded Supervision Reports (XSRs) at IDB Invest. PCRs and XSRs are then validated by OVE to ensure that they are substantiated by evidence and are prepared in accordance with their respective guidelines. Self-evaluations are intended to serve as accountability and learning tools. The IDB Group's project evaluation methodology is objectives-based. Project performance is rated based on four core criteria: (i) relevance of the project's goals and design, (ii) effectiveness or the degree to which the project achieved the specific objectives for which it was approved, (iii) efficiency with which the objectives were achieved, and (iv) sustainability of the results achieved. Each project then receives an overall outcome rating, calculated as a weighted average of the core criteria ratings, where effectiveness has the highest weight. In addition, two noncore criteria are rated for IDB operations (Bank performance and borrower performance), while three are rated for IDB Invest operations (additionality, investment profitability, and work quality). OVE also rates the quality of the self-evaluation reports by Management. The overall outcome is rated on a six-point scale, while core criteria, noncore criteria, and PCR and XSR quality are rated on a four-point scale. For simplicity, this report groups ratings into “positive” and “negative,” where positive corresponds to the top half ratings in the scale, and negative to the bottom half.
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Selph, Shelley S., Andrea C. Skelly, Tracy Dana, et al. Psychosocial and Pharmacologic Interventions for Disruptive Behavior in Children and Adolescents: A Systematic Review. Agency for Healthcare Research and Quality, 2025. https://doi.org/10.23970/ahrqepcsrdisruptive.
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Objectives. To determine the most effective treatments for clinically significant disruptive behaviors in children and adolescents. Data sources. Ovid® MEDLINE®, the Cochrane Library, PsycINFO®, and Embase® databases were searched from 2014 to July 22, 2024. Additionally, we reviewed all studies included in the prior 2015 Agency for Healthcare Research and Quality review. Review methods. We dual reviewed abstracts and full-text articles; data extraction was checked by a second reviewer; risk of bias and strength of evidence were assessed by two reviewers; and disagreements were resolved by consensus. Results. For this review, 168 studies in 194 publications (160 randomized controlled trials [RCTs] and 8 nonrandomized studies) met inclusion criteria. Psychosocial interventions: Multicomponent interventions (parent or teacher plus child) substantially reduced parent-reported disruptive behavior more than usual care or waitlist in preschool children (10 RCTs, N=784, standard mean difference [SMD] -0.96, 95% confidence interval [CI] -1.39 to -0.60) and moderately reduced disruptive behavior in school-age children (9 RCTs, N=524, SMD -0.61, 95% CI -1.05 to -0.20) immediately posttreatment. Similarly, interventions that involved the parent only and not the child also moderately reduced parent-reported disruptive behavior in preschool children (13 RCTs, N=1,222, SMD -0.61, 95% CI 0.99 to -0.31) and slightly reduced disruptive behavior in school-age children (11 RCTs, N=1,289, SMD 0.39, 95% CI 0.58 to 0.22). Comparisons between psychosocial interventions generally showed only minor differences in disruptive behaviors in preschool and school-age children. Findings in adolescents for multicomponent and child-only interventions versus usual care and waitlist and versus another intervention were mixed. Through pairwise, indirect, and network meta-analyses, we were not able to determine whether multicomponent, parent-only, or child-only interventions are superior overall, though there was less evidence in child-only interventions and interventions in adolescents. Pharmacologic interventions: There was limited evidence to support the use of stimulants and/or antipsychotics for disruptive behavior disorders in selected children. Treatment response was more likely with stimulant treatment alone (2 RCTs) and in pooled analysis of add-on risperidone (2 RCTs) and risperidone maintenance (1 RCT) compared with placebo. Study withdrawal due to adverse events was higher with any pharmacotherapy relative to placebo (6 RCTs, N=911, RR 3.44, 95% CI 1.35 to 8.75), although serious adverse events were rare and not different from placebo. Evidence was insufficient to determine whether psychosocial, pharmacological, or a combination of psychological and pharmacological interventions are more effective in reducing disruptive behaviors in children and adolescents. Evidence was also inconsistent or insufficient to determine if benefits and harms of treatment interventions varied based on patient, clinical, or treatment characteristics, or treatment history. Conclusions. Multicomponent psychosocial interventions (parent or teacher plus child) and parent-only psychosocial interventions were better than treatment as usual or waitlist at reducing parent report of child disruptive behaviors for preschool and school-age children immediately post-treatment. In these children, direct and indirect comparisons of multicomponent, parent-only, and child-only interventions generally found no or only minor differences in reducing disruptive behaviors, although effectiveness differed by specific psychosocial intervention. Results of multicomponent interventions and child-only interventions were mixed in adolescents and studies in adolescents were few. Pharmacotherapy may be helpful in reducing disruptive behaviors in some children who have inadequate response to psychosocial interventions. The use of medications was associated with an increased risk of experiencing any adverse event, but serious adverse events were infrequent and similar to placebo. For all age groups, evidence for some psychosocial interventions and all pharmacological interventions was limited, as was reporting of long-term outcomes. Additional research is needed to aid the clinician in selecting the intervention most likely to be effective in reducing disruptive behaviors well beyond treatment completion.
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Review of the Project Completion Reporting System for Sovereign Guarantee Operations. Inter-American Development Bank, 2012. http://dx.doi.org/10.18235/0010437.
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The IDB has made important investments in results measurement and reporting mechanism over the past few years. Although significant improvements have taken place, IDB's main mechanism for reporting on project-level results, the Project Completion Report (PCR), needs to improve. The limited usefulness of PCRs, issues with the PCR template, and limited guidance to PCR authors have contributed to poor quality PCRs. Lack of clarity in the resources available and weak staff incentives to produce good quality reports are also probable causes of poor quality PCRs. Lack of a systematic validation of PCR results might have contributed to the poor incentive structure. In light of the findings, the IDB is advised to improve the PCR system by: (a) revising the current template to better harmonize with the newly updated Development Effectiveness Framework (DEF) and the Evaluation Cooperation Group-Good Practice Standards (ECG-GPS) and adopting the new template by January 2013, (b) strengthening the PCR production process and staff incentives, and (c) using a separate budget code and ensuring adequate funding for PCRs.
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Ex Post Project Evaluations 2004 Annual Report. Inter-American Development Bank, 2005. http://dx.doi.org/10.18235/0010486.
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The Bank's Board approved a new Ex Post Policy (EPP) in October 2003, which mandated two new tasks to OVE: the review and validation of Project Completion Reports and the implementation of ex post project evaluations. The scope of this report (RE-308) is limited to the ex post project evaluation task. It's overall purpose is to present the preliminary findings from the first year's experience in implementing EPP. The preliminary findings draw upon three themes: (i) the individual projects evaluated; (ii) the systematic features of the Bank's monitoring and evaluation system; and (iii) evaluative method standards.
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Global Education Monitoring Report - Non-state actors in education: Who chooses? Who loses? UNESCO, 2021. http://dx.doi.org/10.54676/ytjt5864.
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Non-state actors’ role extends beyond provision of schooling to interventions at various education levels and influence spheres. Alongside its review of progress towards SDG 4, including emerging evidence on the COVID-19 pandemic’s impact, the 2021/2 Global Education Monitoring Report urges governments to see all institutions, students and teachers as part of a single system. Standards, information, incentives and accountability should help governments protect, respect and fulfil the right to education of all, without turning their eyes away from privilege or exploitation. Publicly funded education does not have to be publicly provided but disparity in education processes, student outcomes and teacher working conditions must be addressed. Efficiency and innovation, rather than being commercial secrets, should be diffused and practised by all. To that end, transparency and integrity in the public education policy process need to be maintained to block vested interests. The report’s rallying call – Who chooses? Who loses? – invites policymakers to question relationships with non-state actors in terms of fundamental choices: between equity and freedom of choice; between encouraging initiative and setting standards; between groups of varying means and needs; between immediate commitments under SDG 4 and those to be progressively realized (e.g. post-secondary education); and between education and other social sectors. Supporting the fifth Global Education Monitoring Report are two online tools: PEER, a policy dialogue resource describing non-state activity and regulations in the world’s education systems; and VIEW, a new website consolidating sources and providing new completion rate estimates over time.