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Journal articles on the topic 'Post-hoc moderator analysis'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Hutchins, Nancy S., Mack D. Burke, Lisa Bowman-Perrott, Kevin R. Tarlow, and Heather Hatton. "The Effects of Social Skills Interventions for Students With EBD and ASD: A Single-Case Meta-Analysis." Behavior Modification 44, no. 5 (May 7, 2019): 773–94. http://dx.doi.org/10.1177/0145445519846817.

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Social skills interventions are critical for promoting social, emotional, and behavioral competence for students with or at risk of emotional and behavioral disorders (EBD) and autism spectrum disorders (ASD). This single-case meta-analysis examined the effects of social skills interventions (SSIs) for students with EBD and ASD. Effect sizes were calculated for 78 cases across 25 included studies using a nonparametric effect size, Baseline Corrected Tau. The overall weighted mean effect size of 0.54 suggested a moderate effect across the 25 studies. The overall weighted mean effects for studies reporting maintenance and generalization data were 0.68 and 0.37, respectively. Potential moderators examined (disability, intervention design, intervention delivery, methodological quality) were not significant. As such, they did not moderate the outcomes for participants. We conducted a post hoc analysis and hypothesized that between-study differences may be more meaningful than the similarities shared by participants in the same moderator groups. Implications are discussed on using SSIs to address the social, emotional, and behavioral challenges of students with or at risk of EBD and ASD.

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Lee, So Hee, Jin-Won Noh, Kyoung-Beom Kim, Hae-Woo Lee, Jin Yong Jun, and Won Woong Lee. "The Effects of Inhumane Treatment in North Korean Detention Facilities on the Posttraumatic-Stress Disorder Symptoms of North Korean Refugees." Psychiatry Investigation 18, no. 7 (July 25, 2021): 688–94. http://dx.doi.org/10.30773/pi.2020.0427.

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Objective The study investigated the effects of severe human rights abuses in North Korean on Posttraumatic-stress disorder (PTSD) in North Korean Refugees (NKRs).Methods The study included 300 NKRs (245 females and 55 males) who completed self-report questionnaires that assessed PTSD, experiences of imprisonment, and exposure to inhumane treatment, by authorities in North Korea. A moderation analysis was conducted using a hierarchical multiple regression model to determine whether a moderation effect existed. In the next step, a post-hoc probing procedure of the moderation effect was performed using multiple regression models that included conditional moderator variables.Results The influence of the frequency of being imprisoned on PTSD varied as a function of recurrent exposure to inhumane treatment or punishment by authorities. Experiences of imprisonment were associated with PTSD only among those who were exposed to recurrent violence, such as beating or torture, by North Korean authorities.Conclusion The present findings highlight the significant effects of human rights violations, such as the inhumane treatment of prisoners in North Korea, on the PTSD of NKRs.

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Pellegrino, A. Brooke Walters, Rachel E. Davis-Martin, Timothy T. Houle, Dana P. Turner, and Todd A. Smitherman. "Perceived triggers of primary headache disorders: A meta-analysis." Cephalalgia 38, no. 6 (August 20, 2017): 1188–98. http://dx.doi.org/10.1177/0333102417727535.

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Objective To quantitatively synthesize extant literature on perceived triggers of primary headache disorders. Methods A meta-analytic review of headache trigger survey studies was conducted. Endorsement rates, assessment method, and headache and sample characteristics were extracted from included articles. Separate random-effects models were used to assess trigger endorsement rates and post-hoc meta-regressions examined potential moderator variables. Results 85 articles from 1958 to 2015 were included, involving 27,122 participants and querying 420 unique triggers (collapsed into 15 categories). Four-fifths (0.81; 95% CI .75 to .86) of individuals with migraine or tension-type headache endorsed at least one trigger. Rates increased with the number of categories queried (OR: 1.18, 1.08–1.30) and year of publication (OR: 1.04, 1.00–1.08). The triggers most commonly endorsed were stress (.58, .53–.63) and sleep (.41, .36–.47). Conclusions Extreme heterogeneity characterizes the headache trigger literature. Most individuals with a primary headache disorder perceive their attacks to be triggered by one or more precipitants, the most common of which are stress and sleep. However, trigger endorsement is influenced by method of assessment. Enhancing methodological consistency and prioritizing experimental studies would improve our understanding of headache triggers.

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Best, Ryan, Laure Freydefont, and Alexandra M. Freund. "AGING, TASK DIFFICULTY, AND EFFORT: A META-ANALYSIS." Innovation in Aging 3, Supplement_1 (November 2019): S705. http://dx.doi.org/10.1093/geroni/igz038.2592.

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Abstract Tasks of increasing difficulty require increasing levels of cognitive engagement from participants. The costs associated with cognitive engagement rise with age in response to normative cognitive decline. Additionally, previous studies have shown an interaction between age and task difficulty, with age differences in effort expenditure increasing along with task demands. Motivational accounts of effort allocation predict the opposite relationship, where increased task difficulty in the face of declining cognitive abilities result in disengagement among older adults, comparatively lowering their effort expenditure relative to younger adults that remain committed to the task. The current study quantitatively reviews the available literature on age and effort expenditure across tasks of increasing difficulty. An initial meta-analysis found no age differences in effort across task difficulty, but inspection of the significantly heterogeneous effect sizes indicated that measurement domain might account for some of the variance found between the effect sizes. A second, post-hoc meta-analysis was conducted, recoding effect sizes giving preference to subjective measures. Subsequent moderator variable analyses found that the combined effect of age and domain of effort measurement explained a sufficient portion of the variance across effect sizes. When using physiological measures, effort was not found to differ across task difficulty for either age group. Alternatively, when measured subjectively, effort was reported to greatly increase (>1 standard deviation) with difficulty, with a larger increase in younger adults. Results are discussed in terms of effort mobilization across adulthood and the importance of measurement domain in the interpretation of results.

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Juniarta, P. A. K. "THEMATIC PATTERNING TECHNIQUE ON WRITING ACHIEVEMENT AND ITS RELATIONSHIP TO ACHIEVEMENT MOTIVATION OF THE STUDENTS OF ENGLISH EDUCATION DEPARTMENT GANESHA UNIVERSITY OF EDUCATION." International Journal of Language and Literature 1, no. 2 (November 15, 2017): 99. http://dx.doi.org/10.23887/ijll.v1i2.12543.

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This study aimed at investigating the effect of thematic patterning technique and achievement motivation on students’ writing achievement. The subjects were the second semester students of English Education Department in the academic year 2015/2016 recruited by using cluster random sampling. The population was 7 classes, 2 classes were taken as the sample of the study. The total number of sample was 52 students who were divided into four cells of treatments. The II B class was assigned as the experimental group and II D class as the control group. The experimental group was taught by using thematic patterning technique and the control group by using conventional technique. The research design was post test only control group design by using 2x2 factorial design. There were three variables in this study, namely: independent, moderator, and dependent variables. The independent variable was thematic patterning technique and moderator variable was the students’ achievement motivation level (high and low). In another side, students’ achievement in writing paragraph was categorized as dependent variable. The instrument that was used to test the students’ achievement motivation was achievement motivation questionnaire, while the instrument used to test students’ writing achievement was writing achievement test. The analysis of data used two way Anova and then continued by post hoc testing using Tukey test. The findings of the study were: there was a significant difference in writing achievement between the students who are taught by using thematic patterning technique and those who are taught by using conventional technique. The mean score of students taught by using thematic patterning technique was higher than the mean score of students’ writing achievement for students taught by using conventional technique, there was interaction between of thematic patterning technique and the achievement motivation in learning English on students’ writing achievement.

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Omoniyi, Tayo, Lucky Uzoma Nwosu, and Fakokunde Jubril Busuyi. "Effect of two Computer Instructional Modes on Secondary School Students’ Achievement in Geography, in Lagos State, Nigeria." Journal of Education in Black Sea Region 6, no. 1 (December 4, 2020): 158–66. http://dx.doi.org/10.31578/jebs.v6i1.227.

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There is a growing concern about secondary school students’ poor performance in geography, a subject that is prerequisite for many professional pursuits. To enhance their performance in the subject, several strategies have been adopted. This study is an intervention, which investigated relative effects of computer instructional modes (computer graphics and animations computer) on secondary school students’ achievement in geography. The moderator variable was mental ability. Two hypotheses were formulated and tested at 0.05 level of significance. The pre-test, post-test control group quasi-experimental design, involving 3x2 factorial matrix was adopted for the study. One hundred and four senior secondary two geography students from three secondary schools in Lagos state constituted the sample for the study, which lasted for eight weeks. Two procedural instruments (computer graphics and animation instructional packages) and two measuring instruments, namely Geography Achievement Test r = 0.79, and Mental Ability Test r=0.88 were used. The data collected were analysed using Analysis of Covariance (ANCOVA). The magnitude of the students’ post-test achievement scores was determined using Multiple Classification Analysis (MCA), while Scheffe post-hoc analysis was used to explain the direction and source of significant effects. Findings showed that there were significant main effects of instructional mode on the students’ achievement in geography (F (2, 91) = 14.414, p< 0.05). There was no significant interaction effect of treatment and mental ability on students’ achievement in geography. Consequently, it was recommended that the computer instructional modes be used alongside with conventional method in the teaching of geography. Keywords: computer graphics, computer animation, instructional mode, achievement in geography, mental ability and geography

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Koay, Kian Yeik. "Workplace ostracism and cyberloafing: a moderated–mediation model." Internet Research 28, no. 4 (August 6, 2018): 1122–41. http://dx.doi.org/10.1108/intr-07-2017-0268.

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Purpose This purpose of this paper is to examine the relationship between workplace ostracism and cyberloafing, based on the premise of conservation of resources theory. Emotional exhaustion is tested as a mediator between workplace ostracism and cyberloafing, whereas facilitating conditions are predicted as a moderator that influences employees’ reaction to ostracism. Design/methodology/approach Survey data were collected via the online platform Amazon Mechanical Turk. Partial least squares analysis, a variance-based structural equation modelling, was utilised to verify the research model. Findings The results show that both workplace ostracism and emotional exhaustion have a significant positive relationship with cyberloafing. Likewise, emotional exhaustion partially mediates the relationship between workplace ostracism and cyberloafing. Interestingly, facilitating conditions do not moderate the emotional exhaustion–cyberloafing relationship but do moderate the ostracism–cyberloafing relationship. Counterintuitively, the relationship between workplace ostracism and cyberloafing becomes stronger when facilitating conditions are high. A post hoc analysis has been conducted using PROCESS Macro to test the conditional indirect effect but was found not significant. Originality/value Previous studies have revealed the association between workplace ostracism with various negative work behaviours, such as knowledge hiding, knowledge hoarding and counterproductive work behaviours. This study has successfully identified that workplace ostracism can also result in cyberloafing, which has not been delved into previous works. This has subsequently provided managers with new perspectives regarding why employees engage in non-work-related online activities at work.

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Ting, Hiram, Ernest Cyril de Run, Jun-Hwa Cheah, and Francis Chuah. "Food neophobia and ethnic food consumption intention." British Food Journal 118, no. 11 (November 7, 2016): 2781–97. http://dx.doi.org/10.1108/bfj-12-2015-0492.

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Purpose The purpose of this paper is to serve as groundwork to investigate the determinants of ethnic food consumption intention in the context of developing markets. Using the theory of planned behaviour as the underlying basis, it is aimed to explain the effect of attitude, subjective norm and perceived behaviour control on consumption intention towards Dayak food. Since Dayak food is relatively unfamiliar compared to conventional food in Malaysia, food neophobia is incorporated into the model so as to assess its moderation effect on every postulated relationship. Design/methodology/approach A quantitative approach via self-administered questionnaire was adopted. In all, 300 copies of the questionnaire were distributed to non-Dayak Malaysians, and 211 usable copies were subsequently collected, suggesting that non-response bias was not a major issue. A post hoc Harman single-factor analysis was also performed to ensure the variance in the data was not explained by one single factor, thus addressing the common method bias. Structural equation modelling using partial least squares approach was then utilized to assess the relationships of variables under investigation and the moderation effect of food neophobia. Findings After ensuring the data have acceptable reliability and validity, structural model assessment was performed to test the hypotheses. The findings show that attitude, subjective norm and perceived behavioural control all have positive effect on consumption intention of non-Dayak Malaysians towards Dayak food. However, food neophobia is only found to have a moderation effect on the relationship between subjective norm and consumption intention. Research limitations/implications First, the sample is largely consisted of college and university students in Malaysia who are believed to be more daring to try new things, including new food. Second and more importantly, the dearth of literature and empirical studies on Dayak food and ethnic food in Malaysia might have actually pointed to the limitation in using only quantitative questionnaire in the study. As salient beliefs are the antecedents in the theory of planned behaviour, knowing consumers’ specific beliefs about Dayak food would have provided a more detailed and comprehensive understanding of consumption intention and the moderating effect of food neophobia. Practical implications The moderation effect of food neophobia on the relationship between subjective norm and consumption intention towards Dayak food implies the importance of recommendations and favourable word-of-mouth from the significant ones, such as family members and peers, to make people willing to try and consume it. This corresponds to earlier findings pertaining to the collectivistic culture in Malaysia. Unlike countries with individualistic cultures, Malaysians tend to conform to the consumption choices of significant others. This implies that those whom they hold in high regard, are able to influence them both positively and negatively through their advice or opinions. Originality/value The present study has not only extended the use of theory of planned behaviour in the context of Dayak food consumption intention in a developing country, but it has also deepened the theory by incorporating food neophobia as the moderator to provide additional theoretical explanation to ethnic food consumption intention. Given the wealth of Asian culture, and its significant role in the global marketplace, the understanding of ethnic food consumption intention of the local and foreign consumers using the extended theory of planned behaviour would contribute knowledge not only to consumer behaviour, but also to food and service industry and tourism.

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Cicchetti, Dante, Sheree L. Toth, and Elizabeth D. Handley. "Genetic moderation of interpersonal psychotherapy efficacy for low-income mothers with major depressive disorder: Implications for differential susceptibility." Development and Psychopathology 27, no. 1 (February 2015): 19–35. http://dx.doi.org/10.1017/s0954579414001278.

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AbstractGenetic moderation of interpersonal psychotherapy (IPT) efficacy for economically disadvantaged women with major depressive disorder was examined. Specifically, we investigated whether genotypic variation in corticotropin releasing hormone receptor 1 (CRHR1) and the linked polymorphic region of the serotonin transporter gene (5-HTTLPR) moderated effects of IPT on depressive symptoms over time. We also tested genotype moderation of IPT mechanisms on social adjustment and perceived stress. Non-treatment-seeking urban women at or below the poverty level with infants were recruited from the community (N = 126; M age = 25.33 years, SD = 4.99; 54.0% African American, 22.2% Caucasian, and 23.8% Hispanic/biracial) and randomized to individual IPT or Enhanced Community Standard groups. The results revealed that changes in depressive symptoms over time depended on both intervention group and genotypes (5-HTTLPR and CRHR1). Moreover, multiple-group path analysis indicated that IPT improved depressive symptoms, increased social adjustment, and decreased perceived stress at posttreatment among women with the 0 copies of the CRHR1 TAT haplotype only. Finally, improved social adjustment at postintervention significantly mediated the effect of IPT on reduced depressive symptoms at 8 months postintervention for women with 0 copies of the TAT haplotype only. Post hoc analyses of 5-HTTLPR were indicative of differential susceptibility, albeit among African American women only.

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Gangel, Meghan J., Susan P. Keane, Susan D. Calkins, Lilly Shanahan, and Marion O’Brien. "The Association Between Relational Aggression and Perceived Popularity in Early Adolescence: A Test of Competing Hypotheses." Journal of Early Adolescence 37, no. 8 (March 31, 2016): 1078–92. http://dx.doi.org/10.1177/0272431616642327.

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This study examined two competing hypotheses regarding the moderators of the association between relational aggression and peer status in early adolescence. The mitigation relational aggression hypothesis examined whether positive social behaviors reduced the negative effects of relational aggression, thus amplifying the association between relational aggression and perceived popularity. The effective use of relational aggression hypothesis examined whether leadership skills facilitated the proficient use of relational aggression, thus amplifying the association between relational aggression and perceived popularity. Participants were 158 fifth graders (52% female). Post hoc analyses indicated that for girls, leadership significantly moderated the association between relational aggression and perceived popularity after controlling for positive social behaviors. Positive social behaviors did not similarly moderate the association between relational aggression and perceived popularity for boys or girls. Our results demonstrated that in the context of greater leadership, female early adolescents who used more relational aggression were perceived as more popular.

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Davies, Patrick T., Joanna K. Pearson, Dante Cicchetti, Meredith J. Martin, and E. Mark Cummings. "Emotional insecurity as a mediator of the moderating role of dopamine genes in the association between interparental conflict and youth externalizing problems." Development and Psychopathology 31, no. 3 (May 6, 2019): 1111–26. http://dx.doi.org/10.1017/s0954579419000634.

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AbstractThis study tested whether the association between interparental conflict and adolescent externalizing symptoms was moderated by a polygenic composite indexing low dopamine activity (i.e., 7-repeat allele of DRD4; Val alleles of COMT; 10-repeat variants of DAT1) in a sample of seventh-grade adolescents (Mean age = 13.0 years) and their parents. Using a longitudinal, autoregressive design, observational assessments of interparental conflict at Wave 1 predicted increases in a multi-informant measurement of youth externalizing symptoms 2 years later at Wave 3 only for children who were high on the hypodopaminergic composite. Moderation was expressed in a “for better” or “for worse” form hypothesized by differential susceptibility theory. Thus, children high on the dopaminergic composite experienced more externalizing problems than their peers when faced with more destructive conflicts but also fewer externalizing problems when exposed to more constructive interparental conflicts. Mediated moderation findings indicated that adolescent reports of their emotional insecurity in the interparental relationship partially explained the greater genetic susceptibility experienced by these children. More specifically, the dopamine composite moderated the association between Wave 1 interparental conflict and emotional insecurity 1 year later at Wave 2 in the same “for better” or “for worse” pattern as externalizing symptoms. Adolescent insecurity at Wave 2, in turn, predicted their greater externalizing symptoms 1 year later at Wave 3. Post hoc analyses further revealed that the 7-repeat allele of the dopamine receptor D4 (DRD4) gene was the primary source of plasticity in the polygenic composite. Results are discussed as to how they advance process-oriented Gene x Environment models of emotion regulation.

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Andreas, Stefan, Ulrich Bothner, Alberto de la Hoz, Isabel Kloer, Matthias Trampisch, and Peter Alter. "A Post Hoc Holter ECG Analysis of Olodaterol and Formoterol in Moderate-to-Very-Severe COPD." International Journal of Chronic Obstructive Pulmonary Disease Volume 15 (August 2020): 1955–65. http://dx.doi.org/10.2147/copd.s246353.

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Gottlieb, Alice B., Kim A. Papp, Charles A. Birbara, Catherine L. Shuler, Russel Burge, Janelle Erickson, Lisa Kerr, and Philip J. Mease. "Effect of psoriatic arthritis on ixekizumab clinical outcomes in moderate-to-severe psoriasis patients: A post hoc analysis." Journal of the American Academy of Dermatology 79, no. 3 (September 2018): 593–95. http://dx.doi.org/10.1016/j.jaad.2018.03.008.

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Bodkin, Charles D., Cara Peters, and Jane Thomas. "The impact of employee work perceptions on purchase intentions from a company store." Journal of Product & Brand Management 25, no. 5 (August 15, 2016): 479–89. http://dx.doi.org/10.1108/jpbm-09-2015-0998.

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Purpose Company stores market to their internal employees via the distribution of branded promotional products. The purpose of this study is to investigate factors that may influence when an employee is more likely to purchase from a company store. Design/methodology/approach A survey was administered to the members of a chamber of commerce located in the southeastern USA. Data were analyzed using regression, and post hoc analyses were conducted using an analysis of covariance. Findings Organizational identification and job satisfaction significantly impacted employees’ intentions to purchase from a company store. Gender, education, marital status and years of work experience were personal factors that moderated that relationship. Firm size and employee rank were company factors that moderated the relationship between employee work perceptions and employee purchase intentions at a company store. Originality/value No research to date exists on company stores. This study is unique in that it proposes internal branding as a theoretical foundation for understanding company stores and examines factors that impact employees’ intentions to purchase from a company store.

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Goldberg, Joseph F., Daisy Ng-Mak, Cynthia Siu, Chien-Chia Chuang, Krithika Rajagopalan, and Antony Loebel. "Remission and recovery associated with lurasidone in the treatment of major depressive disorder with subthreshold hypomanic symptoms (mixed features): post-hoc analysis of a randomized, placebo-controlled study with longer-term extension." CNS Spectrums 22, no. 2 (March 7, 2017): 220–27. http://dx.doi.org/10.1017/s1092852917000025.

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ObjectiveThis post-hoc analysis assessed rates of symptomatic and functional remission, as well as recovery (combination of symptomatic and functional remission), in patients treated with lurasidone for major depressive disorder (MDD) associated with subthreshold hypomanic symptoms (mixed features).MethodPatients with MDD plus two or three manic symptoms (defined as per the DSM–5 mixed-features specifier) were randomly assigned to flexible-dose lurasidone 20–60 mg/day (n=109) or placebo (n=100) for 6 weeks, followed by a 3-month open-label, flexible-dose extension study for U.S. sites only (n=48). Cross-sectional recovery was defined as the presence of both symptomatic remission (Montgomery–Åsberg Depression Rating Scale score ≤ 12) and functional remission (all Sheehan Disability Scale [SDS] domain scores ≤3) at week 6, and at both months 1 and 3 of the extension study (“sustained recovery”).ResultsA significantly higher proportion of lurasidone-treated patients (31.3%) achieved recovery (assessed cross-sectionally) compared to placebo (12.2%, p=0.002) at week 6. The number of manic symptoms at baseline moderated the effect size for attaining cross-sectional recovery for lurasidone treatment (vs. placebo) (p=0.028). Sustained recovery rates were higher in patients initially treated with lurasidone (20.8%) versus placebo (12.5%).ConclusionsIn this post-hoc analysis of a placebo-controlled study with open-label extension that involved patients with MDD and mixed features, lurasidone was found to significantly improve the rate of recovery at 6 weeks (vs. placebo) that was sustained at month 3 of the extension study. The presence of two (as opposed to three) manic symptoms moderated recovery at the acute study endpoint.

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Rejeki, P. S., A. Pranoto, R. E. Prasetya, and S. Sugiharto. "Irisin serum increasing pattern is higher at moderate-intensity continuous exercise than at moderate-intensity interval exercise in obese females." Comparative Exercise Physiology 17, no. 5 (September 14, 2021): 475–84. http://dx.doi.org/10.3920/cep200050.

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Lifestyle, unhealthy eating patterns, and low physical activity become trigger factors of obesity. Therefore, lifestyle modification with an exercise-based nonpharmacological approach is one of the strategies for combat obesity. This study aims to analyse the response of moderate-intensity interval and continuous exercise to irisin level increasing pattern on the obese female. A total of 21 obese females were enrolled in this study and given moderate-intensity interval exercise (MIIE) and moderate-intensity continuous exercise (MICE). ELISA was used to quantify the serum level of irisin in all samples. Statistical analysis was performed using one way-ANOVA and Tukey’s honestly significant difference (HSD) post hoc test. Mean irisin levels of pre-exercise at control (CON), MIIE, and MICE were 3.26±1.28l, 3.44±0.56 and 3.89±1.08 ng/ml, respectively (P=0.519). The mean irisin level of 10 min post-exercise was 2.99±0.86 ng/ml at CON, 4.82±1.01 ng/ml at MIIE, and 5.99±1.27 ng/ml at MICE (P=0.000). The mean irisin levels of 6 h post-exercise were 3.04±0.60, 4.56±0.87, and 5.73±1.02 ng/ml at CON, MIIE, and MICE, respectively (P=0.000). The mean irisin level of 24 h post-exercise was 3.04±0.91 ng/ml at CON, 4.64±0.69 ng/ml at MIIE, and 5.69±1.53 ng/ml at MICE (P=0.002). We conclude that the post-exercise serum irisin level increased in both MICE and MIIE subjects, and the post-exercise serum irisin level maintained higher in the MICE than in the MIIE in the obese female subjects.

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Loftus, Edward V., Bruce E. Sands, Jean Frederic Colombel, Iris Dotan, Javaria M. Khalid, David Tudor, and Parnia Geransar. "Sa1776 - Sustained Corticosteroid-Free Remission with Vedolizumab in Moderate-to-Severe Ulcerative Colitis: A Post HOC Analysis of Gemini 1." Gastroenterology 154, no. 6 (May 2018): S—390. http://dx.doi.org/10.1016/s0016-5085(18)31600-7.

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Stein Gold, Linda, Hilary Baldwin, Fran Cook-Bolden, Lawrence Green, Glynis Ablon, Neil Sadick, Jonathan Weiss, and Eric Guenin. "Efficacy and Safety of Tazarotene 0.045% Lotion in Female Patients with Moderate-to-Severe Acne: Post Hoc Analysis by Age." SKIN The Journal of Cutaneous Medicine 5, no. 1 (January 1, 2021): s23. http://dx.doi.org/10.25251/skin.5.supp.23.

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Loftus, E. V., B. E. Sands, J. F. Colombel, I. Dotan, J. M. Khalid, D. Tudor, and P. Geransar. "P422 Sustained corticosteroid-free remission with vedolizumab in moderate-to-severe ulcerative colitis: A post hoc analysis of GEMINI 1." Journal of Crohn's and Colitis 12, supplement_1 (January 16, 2018): S317—S318. http://dx.doi.org/10.1093/ecco-jcc/jjx180.549.

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Alcázar Navarrete, Bernardino, Isabelle Boucot, Ian Naya, Lee Tombs, David A. Lipson, Chris Compton, Ana R. Sousa, and Gregory Feldman. "Umeclidinium/Vilanterol Versus Tiotropium/Olodaterol in Maintenance-Naïve Patients with Moderate Symptomatic Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis." Pulmonary Therapy 4, no. 2 (June 20, 2018): 171–83. http://dx.doi.org/10.1007/s41030-018-0057-7.

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Stein Gold, Linda, Hilary Baldwin, Fran Cook-Bolden, Lawrence Green, Glynis Ablon, Neil Sadick, Jonathan Weiss, and Eric Guenin. "Efficacy and Safety of Tazarotene 0.045% Lotion in Female Patients with Moderate-to-Severe Acne: Post Hoc Analysis by Age." SKIN The Journal of Cutaneous Medicine 5, no. 1 (January 1, 2021): s23. http://dx.doi.org/10.25251/skin.5.supp.23.

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Stender, Karina, and Jeffrey Cummings. "P4-329: Post HOC responder analyses of Memantine treatment on behavioral disturbances in patients with moderate to severe Alzheimer's disease." Alzheimer's & Dementia 4 (July 2008): T769. http://dx.doi.org/10.1016/j.jalz.2008.05.2399.

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Hengartner, Michael P., Silvia Passalacqua, Andreas Andreae, Wulf Rössler, and Agnes von Wyl. "The role of perceived social support after psychiatric hospitalisation: Post hoc analysis of a randomised controlled trial testing the effectiveness of a transitional intervention." International Journal of Social Psychiatry 63, no. 4 (March 27, 2017): 297–306. http://dx.doi.org/10.1177/0020764017700664.

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Background: The association between social support, readmissions and psychopathology following discharge from psychiatric hospitals is not clear. Aims: To examine the prospective effects of perceived social support on rehospitalisation rates and psychopathology and to focus on the moderators of a transitional intervention. Method: This post hoc analysis of a multisite randomised controlled trial included 151 patients with no more than three hospitalisations within the last 3 years, a Global Assessment of Functioning (GAF) score ≤60 and aged 18–64 years, assessed at two psychiatric hospitals from Zurich, Switzerland, between September 2011 and February 2014. Participants received either a transitional intervention aimed at improving social support during the transition from inpatient to outpatient care provided by a social worker or treatment as usual. Results: Lack of perceived social support at discharge significantly predicted subsequent rehospitalisation rates and increased psychopathological impairment across 12-month follow-up. Significant interaction effects between patient characteristics and the intervention on perceived social support comprised living at parent’s home, having no children and being of younger age. Conclusion: Perceived social support at discharge from inpatient care may reduce rehospitalisation rates and psychopathological impairment in the long term. A transitional intervention aimed at improving social support may negatively impact on the perceived social support in some patient groups.

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Hausenblas, Heather A., and Albert V. Carron. "Group Cohesion and Self-Handicapping in Female and Male Athletes." Journal of Sport and Exercise Psychology 18, no. 2 (June 1996): 132–43. http://dx.doi.org/10.1123/jsep.18.2.132.

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There were two main purposes in the present study. The first was to identify the nature of the self-handicaps reported by elite female and male athletes (N = 245). School commitments and sport problems represented the most frequently cited impediments. Female athletes reported a significantly greater number of disruptions and had a greater tendency to report that sport problems, physical state/illness, and family/friend problems hindered their preparation. The second purpose was to determine whether cohesion would moderate the extent to which athletes would use self-handicapping strategies prior to competition. Hierarchical multiple regression revealed that cohesion was a moderator in the relationship between the trait of self-handicapping (Excuse Making) and the use of self-handicapping for both female and male elite athletes. Results of post hoc analyses indicated that athletes who were highly predisposed to self-handicap and who perceived their group as more cohesive, had a greater tendency to proactively perceive impediments to subsequent performance.

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Gisondi, P., G. Girolomoni, K. de Vlam, A. Al Hammadi, S. Carneiro, M. A. Hsu, A. Szumski, H. Jones, G. Gallo, and A. Chhabra. "AB0821 Baseline Characteristics of Patients with Moderate to Severe Psoriatic Arthritis: Post-Hoc Analysis of Responders vs Non-Responders to Etanercept." Annals of the Rheumatic Diseases 74, Suppl 2 (June 2015): 1174. http://dx.doi.org/10.1136/annrheumdis-2015-eular.4738.

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Zvartau, N. E., E. V. Verbitskaya, T. L. Galankin, A. O. Konradi, N. Yu Khozyainova, and M. Yu Samsonov. "NEW ANGIOTENSIN II RECEPTOR BLOCKER FIMASARTAN IN MILD-TO-MODERATE HYPERTENSION: POST-HOC ANALYSIS OF RESULTS OF REGISTRATION TRIAL IN RUSSIA." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 24, no. 1 (March 12, 2018): 110–19. http://dx.doi.org/10.18705/1607-419x-2018-24-1-110-119.

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Reinisch, Walter, Brian Bressler, Rebecca Curtis, Asit Parikh, Huyuan Yang, Maria Rosario, Arne Røseth, et al. "Fecal Calprotectin Responses Following Induction Therapy With Vedolizumab in Moderate to Severe Ulcerative Colitis: A Post Hoc Analysis of GEMINI 1." Inflammatory Bowel Diseases 25, no. 4 (October 5, 2018): 803–10. http://dx.doi.org/10.1093/ibd/izy304.

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Tocco, Michael, Michael Tocco, Suzanne Hendrix, Michael L. Miller, Vojislav Pejovic, and Stephen M. Graham. "Efficacy of Memantine by Baseline Disease Severity: Post-hoc Analysis of Pooled Trials in Patients with Mild to Moderate Alzheimer's Disease." Journal of the American Medical Directors Association 12, no. 3 (March 2011): B10. http://dx.doi.org/10.1016/j.jamda.2010.12.039.

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Pikalov, A., J. Goldberg, Y. Mao, C. Siu, J. Tsai, J. Calabrese, and A. Loebel. "Lurasidone for the Treatment of Major Depressive Disorder with Mixed Features: Do Manic Symptoms Moderate Treatment Response?" European Psychiatry 41, S1 (April 2017): s243. http://dx.doi.org/10.1016/j.eurpsy.2017.02.018.

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BackgroundThis post-hoc analysis evaluated whether the efficacy of lurasidone in major depressive disorder (MDD) with mixed features is moderated by the number and characteristics of manic symptoms present at study baseline.MethodsPatients meeting DSM-IV-TR criteria for MDD who presented with two or three manic symptoms (consistent with the DSM–5 mixed features specifier) were randomly assigned to 6 weeks of double-blind treatment with either lurasidone 20–60 mg/d (n = 109) or placebo (n = 100). Finite mixture models were applied to identify latent class patterns of the 10 baseline manic symptoms.ResultsThree latent class profiles were identified: 105 (50.5%) patients had manic symptom profile 1 (MIX 1) with mean MADRS 33.0, mean YMRS 9.2, mean number of manic symptoms 3.8; 63 (30.3%) patients had manic symptom profile 2 (MIX 2) with similar baseline mean MADRS (32.4) and YMRS (9.3) and lower number of manic symptoms 3.5; 40 patients had manic symptom profile 3 (MIX 3) with significantly higher severity scores in MADRS (35) and YMRS (14.9) and mean number of manic symptoms 4.6. A significant moderating effect on change in YMRS score was observed for the “decreased need for sleep” symptom, with greater lurasidone effect size (vs. Placebo) found in patients without vs. With this symptom (P < 0.05).ConclusionsIn this post-hoc analysis of a placebo-controlled trial involving MDD patients with mixed features, absence of “decreased need for sleep” was found to be significantly associated with improvement in manic and depressive symptoms and to moderate the treatment effect on manic symptoms.Disclosure of interestI am full time employee of Sunovion pharmaceuticals Inc.

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Paul, Carle, Craig Leonardi, Alan Menter, Kristian Reich, Linda Stein Gold, Richard B. Warren, Anders Moller, and Mark Lebwohl. "Calcipotriol Plus Betamethasone Dipropionate Foam is Effective in Patients with Moderate-to-Severe Psoriasis: Post-Hoc Analysis of the PSO-ABLE Study." SKIN The Journal of Cutaneous Medicine 2 (February 23, 2018): S2. http://dx.doi.org/10.25251/skin.2.supp.2.

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31

Hardt, F., M. Becker, V. Brandenburg, J. Grebe, T. Dirrichs, R. F. Gohmann, K. Fehrenbacher, J. Schmoee, and S. D. Reinartz. "Impact of epicardial adipose tissue volume upon left ventricular dysfunction in patients with mild-to-moderate aortic stenosis: A post-hoc analysis." PLOS ONE 15, no. 3 (March 2, 2020): e0229636. http://dx.doi.org/10.1371/journal.pone.0229636.

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Hardi, R., B. Bokemeyer, W. Sandborn, W. Reinisch, I. Shafran, A. Stallmach, R. Ehehalt, et al. "P738 Sustained clinical remission with vedolizumab in Moderate-to-Severe Crohn’s disease: A GEMINI 2 post hoc analysis of Week 14 remitters." Journal of Crohn's and Colitis 12, supplement_1 (January 16, 2018): S485. http://dx.doi.org/10.1093/ecco-jcc/jjx180.865.

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33

Schübel, Ruth, Disorn Sookthai, Judith Greimel, Theron Johnson, Mirja Grafetstätter, Romy Kirsten, Mario Kratz, Cornelia Ulrich, Rudolf Kaaks, and Tilman Kühn. "Key Genes of Lipid Metabolism and WNT-Signaling Are Downregulated in Subcutaneous Adipose Tissue with Moderate Weight Loss." Nutrients 11, no. 3 (March 16, 2019): 639. http://dx.doi.org/10.3390/nu11030639.

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Smaller cross-sectional studies and bariatric surgery trials suggest that weight loss may change the expression of genes in adipose tissue that have been implicated in the development of metabolic diseases, but well-powered intervention trials are lacking. In post hoc analyses of data from a 12-week dietary intervention trial initially designed to compare metabolic effects of intermittent vs. continuous calorie restriction, we analyzed the effects of overall weight loss on the subcutaneous adipose tissue (SAT) transcriptome. Changes in the transcriptome were measured by microarray using SAT samples of 138 overweight or obese individuals (age range: 35–65 years, BMI range: 25–40, non-smokers, non-diabetics). Participants were grouped post hoc according to the degree of their weight loss by quartiles (average weight loss in quartiles 1 to 4: 0%, −3.2%, −5.9%, and −10.7%). Candidate genes showing differential expression with weight loss according to microarray analyses were validated by reverse transcription quantitative polymerase chain reaction (RT-qPCR), and fold changes (FCs) were calculated to quantify differences in gene expression. A comparison of individuals in the highest vs. the lowest weight loss quartile revealed 681 genes to be differentially expressed (corrected p < 0.05), with 40 showing FCs of at least 0.4. Out of these, expression changes in secreted frizzled-related protein 2 (SFRP2, FC = 0.65, p = 0.006), stearoyl-CoA desaturase (SCD, FC = −1.00, p < 0.001), and hypoxia inducible lipid droplet-associated (HILPDA, FC = −0.45, p = 0.001) with weight loss were confirmed by RT-qPCR. Dietary weight loss induces significant changes in the expression of genes implicated in lipid metabolism (SCD and HILPDA) and WNT-signaling (SFRP2) in SAT.

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Howard, Robert, Rupert McShane, James Lindesay, Craig Ritchie, Ashley Baldwin, Robert Barber, Alistair Burns, et al. "Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses." Lancet Neurology 14, no. 12 (December 2015): 1171–81. http://dx.doi.org/10.1016/s1474-4422(15)00258-6.

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Paller, Amy S., Ashish Bansal, Eric L. Simpson, Mark Boguniewicz, Andrew Blauvelt, Elaine C. Siegfried, Emma Guttman-Yassky, et al. "Clinically Meaningful Responses to Dupilumab in Adolescents with Uncontrolled Moderate-to-Severe Atopic Dermatitis: Post-hoc Analyses from a Randomized Clinical Trial." American Journal of Clinical Dermatology 21, no. 1 (December 10, 2019): 119–31. http://dx.doi.org/10.1007/s40257-019-00478-y.

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36

Purwoto, Septyaningrum Putri, Adi Pranoto, Hartono Hartono, and Sugiharto Sugiharto. "Moderate Intensity Training By Listening To Music Decreases Interleukin-6 Levels In Rats." STRADA Jurnal Ilmiah Kesehatan 9, no. 1 (May 3, 2020): 93–101. http://dx.doi.org/10.30994/sjik.v9i1.272.

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The design of this study is the randomized control group posttest-only design, 21 of Rattus Norvegicus Strain Wistar male, 20-24 weeks, 250 ± 350 grams and randomly divided into 3 groups namely CONT (n = 7, control without treatment), MIT (n = 7, moderate intensity training, treadmill with speed 14-16 m/min for 15-30 minutes listening to music tempo 160 beats/min) and HIT (n = 7, high intensity training, treadmill with speed 22-25 m/min for 15-30 minutes listening to music tempo 160 beats/min). The intervention was started from 17.00-20.00 WIB with a frequency of 3 times / week for 10 weeks. Blood is drawn for 12 hours after the last training. Measurement of IL-6 serum levels using the ELISA method. Data analysis techniques using ANOVA test and LSD post hoc test with the Statistical Package for Social Science (SPSS).

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Farlow, Martin R., Gus Alva, Xiangyi Meng, and Jason T. Olin. "A 25-week, open-label trial investigating rivastigmine transdermal patches with concomitant memantine in mild-to-moderate Alzheimer’s disease: a post hoc analysis." Current Medical Research and Opinion 26, no. 2 (November 24, 2009): 263–69. http://dx.doi.org/10.1185/03007990903434914.

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Miller, Michael L., Michael Tocco, Suzanne Hendrix, Robert K. Hofbauer, Stephen M. Graham, and James L. Perhach. "Memantine and prevention of worsening across multiple domains: Post hoc analysis of a randomized, placebo-controlled trial in patients with moderate Alzheimer's disease." Alzheimer's & Dementia 6, no. 4 (July 2010): S307. http://dx.doi.org/10.1016/j.jalz.2010.05.1001.

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39

Hofbauer, Robert K., Michael Tocco, Suzanne Hendrix, Stephen M. Graham, and James L. Perhach. "Memantine and prevention of worsening in functional communication: Post hoc analysis of a randomized, placebo-controlled trial in patients with moderate Alzheimer's disease." Alzheimer's & Dementia 6, no. 4 (July 2010): S312. http://dx.doi.org/10.1016/j.jalz.2010.05.1018.

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Reich, Kristian, Joseph F. Merola, Boni Elewski, Kim A. Papp, Luis Puig, Pheobe Rich, Christopher Cioffi, Eva Cullen, Luke Peterson, and Alice B. Gottlieb. "25800 Bimekizumab for the treatment of moderate to severe psoriasis of the scalp: Post hoc analysis from the BE SURE phase 3 trial." Journal of the American Academy of Dermatology 85, no. 3 (September 2021): AB70. http://dx.doi.org/10.1016/j.jaad.2021.06.307.

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41

Conrad, Curdin, Andreas Körber, Knut Schäkel, Diamant Thaçi, Gero Joks, Maria Jazra, Sven Wegner, Robert Wapenaar, and Carle Paul. "26573 Maintenance of response after guselkumab withdrawal in patients with moderate-to-severe psoriasis: A post hoc analysis of the VOYAGE 2 trial." Journal of the American Academy of Dermatology 85, no. 3 (September 2021): AB107. http://dx.doi.org/10.1016/j.jaad.2021.06.446.

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42

Buyl, Tine, Christophe Boone, and James B. Wade. "CEO Narcissism, Risk-Taking, and Resilience: An Empirical Analysis in U.S. Commercial Banks." Journal of Management 45, no. 4 (March 13, 2017): 1372–400. http://dx.doi.org/10.1177/0149206317699521.

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In this study, we investigate how CEO narcissism, in combination with corporate governance practices, impacts organizational risk-taking and how this in turn affects organizations’ resilience to environmental conditions. We examine these issues in the context of the recent collapse (systemic shock) of the U.S. banking industry in September 2008, using a sample of 92 CEOs from 2006 until 2014. We find that before the shock CEO narcissism positively affected the riskiness of banks’ policies, especially when compensation policies that encourage risk-taking (stock options) are in place. The positive effect of narcissism was dampened, however, when board monitoring was more effective (because of the presence of knowledgeable outsider directors). Furthermore, we find that these preshock features hamper organizations’ resilience to (economic) shocks, as banks led by more narcissistic CEOs before the September 2008 collapse experienced a slower recovery to preshock performance levels afterwards. This effect was partially mediated by banks’ preshock riskiness of policies. We attribute these effects to the associated depletion of the organizations’ internal resources (beyond slack). Post-hoc analyses further underscore this idea, showing that the U.S. government’s capital injections through the Troubled Assets Relief Program (TARP)—resolving the “problem” of resource depletion—moderated these effects.

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Singh, Sanjay Kumar, Shashank Mittal, Atri Sengupta, and Rabindra Kumar Pradhan. "A dual-pathway model of knowledge exchange: linking human and psychosocial capital with prosocial knowledge effectiveness." Journal of Knowledge Management 23, no. 5 (June 10, 2019): 889–914. http://dx.doi.org/10.1108/jkm-08-2018-0504.

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Purpose This study aims to examine a dual-pathway model that recognizes two distinct (formal and informal) but complementary mechanisms of knowledge exchanges – knowledge sharing and knowledge helping. It also investigates how team members use their limited human and psychosocial capital for prosocial knowledge effectiveness. Design/methodology/approach A survey-based approach was used to examine the hypotheses of the study. A moderated-mediation model was proposed and tested using bootstrap approach. Findings Knowledge sharing and knowledge helping were found to be the significant links through which human capital (capability) and psychosocial capital (motivation and efficacy) significantly predict prosocial knowledge effectiveness. Post hoc analysis suggests that human capital through knowledge sharing influences team learning, whereas the psychosocial capital through knowledge helping influences team leadership. Originality/value The present study found two distinct but complementary and yet necessary mechanisms of knowledge exchanges to be linked as the important outlay for the human and psychosocial capital to be effective in the prosocial knowledge behaviours.

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44

Kerkhof, P. C. M., R. Loewe, U. Mrowietz, M. Falques, I. Pau‐Charles, and J. C. Szepietowski. "Quality of life outcomes in adults with moderate‐to‐severe plaque psoriasis treated with dimethylfumarate ( DMF ): a post hoc analysis of the BRIDGE study." Journal of the European Academy of Dermatology and Venereology 34, no. 1 (October 17, 2019): 119–26. http://dx.doi.org/10.1111/jdv.15922.

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45

Pae, Chi-Un. "Early versus conventional switching of antidepressant: a post-hoc analysis of clinical trial data for major depressive disorder with moderate to severe pain symptoms." Expert Opinion on Pharmacotherapy 13, no. 18 (November 10, 2012): 2711–15. http://dx.doi.org/10.1517/14656566.2012.742507.

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46

Prevot, Flavien, David Fuks, Cyril Cosse, Karine Pautrat, Simon Msika, Muriel Mathonnet, Haitham Khalil, François Mauvais, and Jean-Marc Regimbeau. "The Value of Abdominal Drainage After Laparoscopic Cholecystectomy for Mild or Moderate Acute Calculous Cholecystitis: A Post Hoc Analysis of a Randomized Clinical Trial." World Journal of Surgery 40, no. 11 (June 28, 2016): 2726–34. http://dx.doi.org/10.1007/s00268-016-3605-z.

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47

Habjanič, Nina, Vesna Lužar-Stiffler, Mojca Kerec-Kos, and Darja Grabnar Peklar. "Efficacy of Calcipotriol-Betamethasone Ointment in Patients with Mild to Moderate Plaque Psoriasis: Subgroup Analyses." Dermatology 235, no. 6 (2019): 501–8. http://dx.doi.org/10.1159/000502516.

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Background: Several factors have been shown to affect psoriasis pathogenesis, clinical presentation and treatment response. Objectives: The aim of this study was to investigate the potential relationship between patients’ baseline characteristics and the efficacy of calcipotriol-betamethasone ointment in patients with mild to moderate plaque psoriasis and to evaluate whether the efficacy is consistent across subgroups. Method: Using data from the therapeutic equivalence study on patients with plaque psoriasis, post hoc analyses were performed to evaluate the impact of baseline demographic and disease characteristics, habits and comorbidities on the response to treatment with calcipotriol-betamethasone ointment. Results: Body mass index (BMI) and obesity were each independently associated (univariate analysis, p < 0.05) with reduction in modified Psoriasis Area and Severity Index (mPASI) and PASI75 (≥75% improvement in mPASI from baseline). Increased body weight is more common in patients with late-onset psoriasis. There was a significant trend for lower response rates with increasing BMI (p = 0.007) and obesity (p = 0.003). The odds of achieving PASI75 is 2.3 times lower for obese compared to normal-weight subjects.If patients with obesity or hypertension were treated with calcipotriol-betamethasone, they were still more likely to achieve PASI75 after 4-week treatment compared to vehicle (p < 0.001). Conclusion: Increased BMI and obesity present risk factors for reduced treatment effectiveness. Importantly, the efficacy of calcipotriol-betamethasone ointment was consistent in all subgroups.

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Weidinger, Stephan, Andrew Pink, Juan Francisco, Azra Kurbasic, Christina Olsen, Andreas Vilsbøll, and Marjolein De Bruin Weller. "Tralokinumab Improves Clinically Relevant Outcome Measures: A Post Hoc Analysis of ECZTRA 3, A Randomized Clinical Trial in Patients with Moderate-To-Severe Atopic Dermatitis." SKIN The Journal of Cutaneous Medicine 4, no. 6 (October 27, 2020): s100. http://dx.doi.org/10.25251/skin.4.supp.100.

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49

Poulin, Y., J. J. Crowley, R. G. Langley, K. Unnebrink, O. M. Goldblum, and W. C. Valdecantos. "Efficacy of adalimumab across subgroups of patients with moderate‐to‐severe chronic plaque psoriasis of the hands and/or feet: post hoc analysis of REACH." Journal of the European Academy of Dermatology and Venereology 28, no. 7 (June 22, 2013): 882–90. http://dx.doi.org/10.1111/jdv.12198.

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50

Yosipovitch, Gil, Luz Fonacier, Sonja Ständer, John Su, Melinda Gooderham, Jacek Szepietowski, Mette Deleuran, et al. "Pruritus, Sleep, and Productivity: A Post Hoc Analysis of Abrocitinib Versus Placebo in Patients With Moderate-to-Severe Atopic Dermatitis (AD) From JADE MONO-2." Journal of Allergy and Clinical Immunology 147, no. 2 (February 2021): AB34. http://dx.doi.org/10.1016/j.jaci.2020.12.158.

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