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Journal articles on the topic 'Post Intrathecal Morphine'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Omara, MD, Amany Faheem Abd El Salam, and Asmaa Fawzy Amer, MD. "Effect of intrathecal morphine before and after laminectomy on intraoperative surgical stress response and post-operative pain: A prospective randomized study." Journal of Opioid Management 16, no. 1 (2020): 15–22. http://dx.doi.org/10.5055/jom.2020.0546.

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Study objective: Intrathecal administration of morphine.Design: A prospective, randomized, controlled study.Setting: Operating room.Patients: Ninety patients of American Society of Anesthesiologists physical statuses I and II undergoing lumbar laminectomy.Interventions: Pre-emptive versus post-operative intrathecal morphine injection, compared to a control group.Main outcome: The visual analog score at the time of discharge and 2, 4, 6, 8, 10, 12, 18, and 24 h later, serum cortisol level, the number of patients needing post-operative rescue analgesia, its duration, and the total amount require

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2

Peralta, Feyce M., Cynthia A. Wong, Nicole Higgins, Paloma Toledo, Mary Jane Jones, and Robert J. McCarthy. "Prophylactic Intrathecal Morphine and Prevention of Post–Dural Puncture Headache." Anesthesiology 132, no. 5 (2020): 1045–52. http://dx.doi.org/10.1097/aln.0000000000003206.

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Abstract Background Prophylactic epidural morphine administration after unintentional dural puncture with a large-bore needle has been shown to decrease the incidence of post–dural puncture headache. The authors hypothesized that prophylactic administration of intrathecal morphine would decrease the incidence of post–dural puncture headache and/or need for epidural blood patch after unintentional dural puncture. Methods Parturients with an intrathecal catheter in situ after unintentional dural puncture with a 17-g Tuohy needle during intended epidural catheter placement for labor analgesia wer

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Shrestha, A., and B. Pradhan. "Use of intrathecal morphine for analgesia in a surgical camp set up in Nepal." Journal of Institute of Medicine Nepal 27, no. 3 (2005): 34–37. http://dx.doi.org/10.59779/jiomnepal.202.

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Background: Pain management is often inadequately addressed, especially in a mobile surgical camp set up. We try to look at an easier and effective method, i.e. intrathecal morphine for pain relief and it’s practicability in a camp set up.Method: 89 patients under going vaginal hysterectomy under spinal anesthesia were studied. They were randomly allocated to those receiving bupivacaine and intrathecal morphine (n=61) and another group receiving bupivacaine only (n=28). Their need for post operative analgesia and untoward effects like nausea/ vomiting, pruritis and respiratory depression were

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4

Gray, John R., Glenn A. Fromme, Lee A. Nauss, Josef K. Wang, and Duane M. Ilstrup. "Intrathecal Morphine for Post-Thoracotomy Pain." Anesthesia & Analgesia 65, no. 8 (1986): 873???876. http://dx.doi.org/10.1213/00000539-198608000-00009.

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Gami, Rupesh Kumar, Kumar Jahan, and Chandra Bhushan Jha. "Efficacy and safety of intrathecal morphine for post cesarean section analgesia." Journal of Society of Anesthesiologists of Nepal 1, no. 1 (2015): 13–17. http://dx.doi.org/10.3126/jsan.v1i1.13583.

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Background: Government of Nepal has been conducting Cesarean section under “Safe Motherhood” program all over country. The purpose of this study was to evaluate the efficacy and safety of intrathecal morphine for post cesarean analgesia under spinal anesthesia. Methods: A total of 300 parturients posted for Cesarean section under spinal anesthesia were divided into two groups of 150 each in this prospective randomized case-control study. Morphine group received 0.15 mg of intrathecal morphine mixed in 12 mg of 0.5% bupivacaine heavy while control group received 12 mg of 0.5% bupivacaine heavy

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Palmer, Craig M., Scott Emerson, Dimitri Volgoropolous, and Diane Alves. "Dose-Response Relationship of Intrathecal Morphine for Postcesarean Analgesia." Anesthesiology 90, no. 2 (1999): 437–44. http://dx.doi.org/10.1097/00000542-199902000-00018.

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Background This series investigated the quality of analgesia and the incidence and severity of side effects of intrathecal morphine for post-cesarean analgesia administered over a dose range of 0.0-0.5 mg. Methods ONE hundred eight term parturients undergoing cesarean delivery at term and given spinal anesthesia were randomized to receive a single dose of intrathecal morphine (0.0, 0.025, 0.05, 0.075, 0.1, 0.2, 0.3, 0.4, or 0.5 mg). A patient-controlled analgesia (PCA) device provided free access to additional analgesics. PCA morphine use, incidence and severity of side effects, and need for t

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7

Zakowski, M., S. Ramanathan, and H. Turndorf. "INTRATHECAL MORPHINE FOR POST-CESAREAN SECTION ANALGESIA." Anesthesiology 71, Supplement (1989): A870. http://dx.doi.org/10.1097/00000542-198909001-00870.

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8

Kumar Ajjappa, Arun, Rajesh Munigial, and Shivakumar K P. "A Comparative Study Between Chlorpheniramine Maleate vs Cetirizine in Prevention of Intrathecal Morphine Induced Pruritusin Patients Undergoing Caesarean Section." Indian Journal of Anesthesia and Analgesia 8, no. 3 (2021): 299–302. http://dx.doi.org/10.21088/ijaa.2349.8471.8321.42.

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Background and Objectives: Morphine has been used spinally for postoperative pain management for long time. However post-operative nausea, vomiting and pruritus are some of the common adverse effects of it.The incidence of pruritus being 20-100%, the prevention of pruritus remains a major challenge. This study was conducted tocompare the efficacy of chlorpheniramine maleate versus cetirizine in prevention of post-operative pruritus in patients receiving intrathecal morphine for lower segment caesarean section. Methods: 60 parturients undergoing caesarean delivery were randomly allocated in 2 g

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9

Kresnoadi, Erwin. "The Difference Duration between Analgesia Bupivacaine Hyperbaric Morphine and Bupivacaine Hyperbaric Epinephrine Intrathecal toward Post Surgery of Sectio Caesaria Patient in Bhayangkara Mataram Hospital." Pain medicine 4, no. 1 (2019): 5–14. http://dx.doi.org/10.31636/pmjua.v4i1.1.

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Background and Objectives: The most used of regional anesthesia technic is spinal anesthesia. Spinal anesthesia is an easier technic to get the depth and speed of nerve blockade. Some medicine can be used as an adjuvant of local anesthesia to increase the effect of analgesia bupivacaine. This research is aimed to compare the effectiveness of administration of 0.1 mg intrathecal morphine and 0.1 mg intrathecal epinephrine to prolong 0.5% 12.5 mg hyperbaric analgesia bupivacaine toward caesarean section postoperative period. Method: This research is an experimental clinical trial randomized doub

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10

Grider, Jay S. "Patient Selection and Outcomes Using a LowDose Intrathecal Opioid Trialing Method for Chronic Nonmalignant Pain." Pain Physician 4;14, no. 4;7 (2011): 343–51. http://dx.doi.org/10.36076/ppj.2011/14/343.

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Background: Various methods exist for trialing patients for intrathecal drug delivery. Currently no standards exist regarding “best practices” for trialing techniques. Objectives: The specific aim of the current study is to report results of patients trialed using a low-dose intrathecal morphine technique in the treatment of chronic noncancer pain. Setting: academic pain medicine practice Study Design: Retrospective Review Method: Visual analog pain scores (VAS) were obtained at the initial visit, after a 6 week opioid-free interval prior to trial, at intrathecal doses of 25, 50, 100, 200 and

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11

Moallemy, Abbas, Hashem Jarineshin, Alireza Abdullazadeh Baghae, Fereydoon Fekrat, Mohammad Hadi Shuruei, and Mostafa Ozhand. "A comparative study of the effects of adding intrathecal morphine and pethidine to bupivacaine in spinal anesthesia during cesarean section: A randomized clinical trial." Ethiopian Medical Journal 63, no. 1 (2025): 323–28. https://doi.org/10.4314/emj.v63i1.5.

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Background: Intrathecal opioids are routinely used during spinal anesthesia for post cesarean analgesia. In this research, the analgesic effects of adding pethidine or morphine to intrathecal bupivacaine have been compared. Methods: In a double-blinded, randomized trial, 110 parturients who were scheduled for elective cesarean section were randomized into two groups of 55 patients each. In one group, 12 mg of bupivacaine (0.5%) plus 200 mcg of intrathecal morphine and in the second group 12 mg of bupivacaine (0.5%) plus 20 mg of pethidine in a total volume of 3 cc was injected as an intratheca

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12

Contaifer, Júlia Silva, and Lucila Annie Baldiotti Farias. "EFEITOS DA RAQUIANESTESIA ASSOCIADA AO TAP BLOCK VS RAQUIANESTESIA SIMPLES COM MORFINA EM GESTANTES SUBMETIDAS À CESARIANA." Revista ft 29, no. 142 (2025): 28–29. https://doi.org/10.69849/revistaft/ar10202501172328.

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Objective: To compare the effects of intrathecal morphine spinal anesthesia with simple spinal anesthesia associated with transverse abdominal plane block (TAP Block) in pregnant women undergoing cesarean section. Methods: It’s a prospective, descriptive, and controlled study conducted at the Obstetric Center of the Regional Hospital of Sobradinho, Brasília-DF, between September and November 2024. Thirty-nine pregnant women were included, divided into two groups: Control Group (CG), composed of 18 participants undergoing simple spinal anesthesia with intrathecal morphine (100 µg), and Interven

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13

Kim, Ae Ra, and Myung Ho Kim. "Small Dose Intrathecal Morphine for Post-cesarean Analgesia." Korean Journal of Anesthesiology 42, no. 5 (2002): 641. http://dx.doi.org/10.4097/kjae.2002.42.5.641.

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14

Yucel, S., H. Y. Cetin, A. Onal, and F. Z. Askar. "Effectiveness of intrathecal morphine for post-thoracotomy pain." European Journal of Anaesthesiology 19, Supplement 27 (2002): 26. http://dx.doi.org/10.1097/00003643-200219271-00078.

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15

Cohen, E., and D. M. Thys. "A801 INTRATHECAL MORPHINE REDUCES POST THORACOTOMY MEPERIDINE REQUIREMENTS." Anesthesiology 73, no. 3A (1990): NA. http://dx.doi.org/10.1097/00000542-199009001-00799.

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16

Carney, M. D., J. H. Weiss, M. C. Norris, and B. L. Leighton. "A949 Intrathecal Morphine and Post Dural Puncture Headache." Anesthesiology 73, no. 3A (1990): NA. http://dx.doi.org/10.1097/00000542-199009001-00947.

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17

Jhamandas, K. H., M. Sutak, and G. Henderson. "Antinociceptive and morphine modulatory actions of spinal orphanin FQ." Canadian Journal of Physiology and Pharmacology 76, no. 3 (1998): 314–24. http://dx.doi.org/10.1139/y98-019.

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Orphanin FQ (nociceptin, OFQ), a heptadecapeptide peptide, has been designated as an endogenous ligand at the orphan receptor ORL1, which lacks affinity for opioid receptor ligands. OFQ-like immunoreactivity has been localized in spinal cord areas that are involved in the processing of nociceptive signals. In this study, the effects of spinally administered OFQ on thermal and mechanical nociceptive stimuli were investigated following intrathecal (i.t.) injection in unanesthetized rats bearing chronic indwelling catheters in the subarachnoid space. Intrathecal OFQ produced two distinct acute ac

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18

Gupta, Aditi, Anshuman Sarkar, Sumantra Sarathi Banerjee, Srimanta Kumar Haldar, Gaurav Aggarwal, and Tarun Jindal. "Evaluation of Post-operative Analgesia with Intrathecal Morphine after Laparoscopic or Robotic Nephrectomy: A Randomised Controlled Trial." Journal of Onco-Anaesthesiology and Perioperative Medicine 2, no. 2 (2025): 62–67. https://doi.org/10.4103/joapm.joapm_46_24.

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Background and Aims: Post-operative pain management in minimally invasive nephrectomy remains a critical aspect of patient care. This study explores the potential of low-dose intrathecal preservative-free morphine as a promising analgesic modality for enhancing post-operative pain control when minimising systemic opioid requirements and associated side effects, thereby improving patient outcomes. Methods: Patients scheduled for elective laparoscopic or robotic-assisted nephrectomy were included in this single-centre, double-blind, randomised, placebo-controlled trial. Preoperatively, patients

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19

Koju, RB, BS Gurung, and Y. Dongol. "Effectiveness of Intrathecal Morphine for Analgesia following Elective Caesarean Section." Nepal Journal of Obstetrics and Gynaecology 10, no. 1 (2015): 57–61. http://dx.doi.org/10.3126/njog.v10i1.13198.

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Aims: This study evaluates the effectiveness of usage of 0.2 mg intrathecal morphine as post-operative analgesia and its effect on activity of mother after elective cesarean section. Methods: This hospital based prospective, randomized, double-blinded and placebo controlled study was carried out at Nagarik Community Teaching Hospital, Bhaktapur between 2012 January to 2014 November after the approval was taken from the hospital authority and the written informed consent from the participating patients. Fifty women of ASA I or II physical status undergoing cesarean section under sub-arachnoid b

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Rebel, MD, Annette, Paul Sloan, MD, and Michael Andrykowski, PhD. "Postoperative analgesia after radical prostatectomy with high-dose intrathecal morphine and intravenous naloxone: A retrospective review." Journal of Opioid Management 5, no. 6 (2018): 331–39. http://dx.doi.org/10.5055/jom.2009.0033.

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Background and methods: Intrathecal opioids (ITOs) have been used for decades to control postoperative pain. Intrathecal opioid dosing is limited, however, by opioid-related side effects, most importantly respiratory depression. To overcome these limitations, we combined intrathecal morphine with a continuous intravenous (IV) postoperative naloxone infusion to control opioid-related side effects. The purpose of this study is to document the efficacy and safety of high-dose intrathecal morphine combined with postoperative naloxone infusion to provide postoperative analgesia after major surgery.

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Miliauskas, Povilas, Renatas Tikuišis, Saulius Cicėnas, Aleksas Žurauskas, and Narimantas Evaldas Samalavičius. "Potorakotominis intratekalinis skausmo malšinimas morfinu." Lietuvos chirurgija 5, no. 3 (2007): 0. http://dx.doi.org/10.15388/lietchirur.2007.3.2190.

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Povilas Miliauskas, Renatas Tikuišis, Saulius Cicėnas, Aleksas Žurauskas, Narimantas Evaldas SamalavičiusVilniaus universiteto Onkologijos institutas,Santariškių g. 1, LT-08660 VilniusEl paštas: povilas.miliauskas@gmail.com Įvadas / tikslas Šoninė torakotomija yra viena iš skausmingiausių operacijų. Šiame darbe nagrinėti ligonių, kuriems atliekamos plaučių operacijos, pooperacinio nuskausminimo aspektai. Buvo siekta palyginti intratekaliniu būdu ir į veną švirkščiamo morfino skausmo malšinamąjį efektyvumą po plaučių operacijos atliekant šoninę torakotomiją. Metodai Ligoniai, kuriems buvo atlie

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Rodríguez, Yuliel Varona, Liliam Maria Castle Manresa, Ariane Sainz Cut, Julius Michel Arias, and Loved White. "Effectiveness of subarachnoid anesthesia with morphine as treatment of postoperative pain in cesarean section." Journal of Anesthesia and Critical Care: Open access 16, no. 1 (2024): 15–18. http://dx.doi.org/10.15406/jaccoa.2024.16.00582.

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Foundation: The Postoperative pain is considered time-limited pain, often poorly controlled. Its management requires a great challenge, since postoperative analgesia must provide the mother with adequate control and at the same time facilitate care for the baby. Objective: To evaluate the effectiveness of postoperative analgesia with the use of intrathecal morphine. Method: Observational, descriptive and cross-sectional study carried out at the Martín Chang Puga General Teaching Hospital in the Nuevitas municipality, province of Camagüey, between January 2021 and December 2022. The sample was

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23

Singh, SN, A. Subedi, JN Prasad, and MC Regmi. "A comparative study to assess the effect of intrathecal bupivacaine with morphine or butorphanol on post-operative pain relief following abdominal and vaginal hysterectomy." Health Renaissance 11, no. 3 (2014): 246–49. http://dx.doi.org/10.3126/hren.v11i3.9640.

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Background: Post-operative pain management can be challenging. Objectives: To compare the efficiency of morphine with that of butorphanol in controlling the postoperative pain relief. Methods: This double-blind randomized clinical trial was performed on 75 consecutive patients. Intrathecal 3ml hyperbaric bupivacaine mixed with morphine (200 microgm-0.25ml); or mixed with butorphanol (200 microgm-0.25ml); or mixed with normal saline 0.25ml was administered to alternate groups (25 patients in each group), for postoperative pain relief after abdominal and vaginal hysterectomy. They were monitored

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Liu, N., G. Kuhlman, F. C.A.pron, et al. "R109 Association morphine -sufentanil intrathecal pour analgesie post-thoracotomie." Annales Françaises d'Anesthésie et de Réanimation 17, no. 8 (1998): 866. http://dx.doi.org/10.1016/s0750-7658(98)80228-1.

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25

Mason, N., R. Gondret, A. Junca, and F. Bonnet. "Intrathecal sufentanil and morphine for post-thoracotomy pain relief †." British Journal of Anaesthesia 86, no. 2 (2001): 236–40. http://dx.doi.org/10.1093/bja/86.2.236.

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26

Basnet, Ujjwal. "A Comparative study of intrathecal hyperbaric Bupivacaine with or without Morphine for Post-Operative Analgesia in Hysterectomy." Nepal Journal of Obstetrics and Gynaecology 13, no. 1 (2018): 34–37. http://dx.doi.org/10.3126/njog.v13i1.21615.

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Aims: The aim of the study is to compare the effect of addition of morphine with bupivacaine and bupivacaine alone in intrathecal anesthesia for the quality and the duration of analgesia in hysterectomy.Methods: Prospective randomized analytical study was conducted in patients undergoing hysterectomy under spinal anesthesia over period of one year. Patients were randomized into two groups: hyperbaric bupivacaine (15mg) only or hyperbaric Bupivacaine (15mg) plus Morphine (0.2mg). The mean duration for the request of first analgesia in post-operative period, mean visual analogue scale (VAS) scor

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Merrill, Dante, Shilen P. Thakrar, Edward Springel, and J. Butterworth. "Intrathecal hydromorphone vs intrathecal morphine: A lack of consensus in post-cesarean section analgesia." Perioperative Care and Operating Room Management 27 (June 2022): 100248. http://dx.doi.org/10.1016/j.pcorm.2022.100248.

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28

Thay, Yu Jia, Qing Yuan Goh, Reena Nianlin Han, Rehena Sultana, and Ban Leong Sng. "Pruritus and postoperative nausea and vomiting after intrathecal morphine in spinal anaesthesia for caesarean section: Prospective cohort study." Proceedings of Singapore Healthcare 27, no. 4 (2018): 251–55. http://dx.doi.org/10.1177/2010105818760340.

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Background: Spinal anaesthesia is a common anaesthetic technique for caesarean sections. Neuraxial opioids such as intrathecal morphine may cause common adverse effects (pruritus, post-operative nausea and vomiting). Objectives: We investigated the incidence, severity and need for treatment of pruritus and post-operative nausea and vomiting following administration of intrathecal morphine in spinal anaesthesia for caesarean section at KK Women’s and Children’s Hospital, Singapore. Methods: We conducted a prospective study involving 124 parturients who received intrathecal morphine in spinal an

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Askar, FZ, S. Kocabas, S. Yucel, O. Samancilar, HY Cetin, and M. Uyar. "The Efficacy of Intrathecal Morphine in Post-thoracotomy Pain Management." Journal of International Medical Research 35, no. 3 (2007): 314–22. http://dx.doi.org/10.1177/147323000703500305.

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Palmer, C. M., W. Nogami, and D. Alves. "Oral Clonidine: Use with Intrathecal Morphine for Post-cesarean analgesia." Anesthesiology 2000, no. 4 (2000): NA. http://dx.doi.org/10.1097/00000542-200004001-00057.

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Chung, Chan-Jong, Ji-Su Kim, Han-Suk Park, and Young-Jhoon Chin. "The Efficacy of Intrathecal Neostigmine, Intrathecal Morphine, and Their Combination for Post-Cesarean Section Analgesia." Anesthesia & Analgesia 87, no. 2 (1998): 341–46. http://dx.doi.org/10.1097/00000539-199808000-00020.

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Chung, Chan-Jong, Ji-Su Kim, Han-Suk Park, and Young-Jhoon Chin. "The Efficacy of Intrathecal Neostigmine, Intrathecal Morphine, and Their Combination for Post-Cesarean Section Analgesia." Anesthesia & Analgesia 87, no. 2 (1998): 341–46. http://dx.doi.org/10.1213/00000539-199808000-00020.

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Chung, C.-J., J.-S. Kim, H.-S. Park, and Y.-J. Chin. "The Efficacy of Intrathecal Neostigmine, Intrathecal Morphine/ and Their Combination for Post-Cesarean Section Analgesia." Obstetric Anesthesia Digest 19, no. 1 (1999): 52–56. http://dx.doi.org/10.1097/00132582-199903000-00018.

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Espinós Ramírez, Carles, Gisela Roca Amatria, Pere Castellví Obiols, et al. "Assessing the Experience and Management of Acute Post-Operative Pain from Caesarean Delivery: A Multi-Centre Cohort Study." Journal of Clinical Medicine 14, no. 13 (2025): 4638. https://doi.org/10.3390/jcm14134638.

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Background: Caesarean section is considered one of the surgeries with the highest prevalence of postoperative pain, yet this is often underestimated and undertreated. This study was aimed at evaluating the prevalence and severity of postoperative pain, assessing which analgesic strategy is the most effective and identifying those risk factors associated with poorer analgesic results. Methods: A multi-centre observational study was conducted on 514 women undergoing elective caesarean section. The primary endpoints included postoperative pain severity at rest and with movement at 6 and 24 h. Res

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Brennan, Timothy J., Eric F. Umali, and Peter K. Zahn. "Comparison of Pre- versus Post-incision Administration of Intrathecal Bupivacaine and Intrathecal Morphine in a Rat Model of Postoperative Pain." Anesthesiology 87, no. 6 (1997): 1517–28. http://dx.doi.org/10.1097/00000542-199712000-00031.

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Background Preclinical studies in experimental animals suggest that preemptive analgesia may improve postoperative pain management. The beneficial effects of preemptive analgesia appear less remarkable clinically. The purpose of this study is to examine the effect of pre- and post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model for postoperative pain. Methods Rats with intrathecal catheters were anesthetized with halothane, and the surgical field was prepared. A saline vehicle or the test drug was administered 15 min before an incision was made in the

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&NA;. "Children who receive intrathecal (Ith) morphine during anaesthesia induction require less post-surgical IV morphine,." Inpharma Weekly &NA;, no. 1454 (2004): 10. http://dx.doi.org/10.2165/00128413-200414540-00020.

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Sharma, N. R., and P. Shrestha. "Use of ondansetron to prevent postspinal morphine induced vomiting." Journal of Institute of Medicine Nepal 29, no. 3 (2007): 21–24. http://dx.doi.org/10.59779/jiomnepal.308.

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Background: The use of Ondansetron, a selective serotonin type 3 (5-hydroxytryptamine [5-HT3] antagonists has been used to prevent postspinal morphine induced vomiting in post-surgical cases. Besides this it has been widely used for the prevention of vomiting induced by chemotherapy postanaesthesia and radiotherapy. Methods: A prospective study was carried out for the use of ondansterone to prevent morphine induced post spinal vomiting in vaginal hysterectomy cases at Gaur, Mahottari district in eastern part of Nepal from 02 - 12 - 2006 to 09- 12- 2006. A total of 100 cases were taken in the s

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Ibach, PharmD, Bethany W., Carol Loeber, MSN, APRN-CNP, Mohanad Shukry, MD, Tracy M. Hagemann, PharmD, FCCP, FPPAG, Donald Harrison, PhD, FAPhA, and Peter N. Johnson, PharmD, BCPS. "Duration of intrathecal morphine effect in children with idiopathic scoliosis undergoing posterior spinal fusio." Journal of Opioid Management 11, no. 4 (2015): 295. http://dx.doi.org/10.5055/jom.2015.0278.

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Objective: Intrathecal (IT) morphine improves pain control and decreases opioid requirements in children following thoracic and abdominal surgery. However, studies in children report variable durations of analgesia following IT morphine. The purpose of this study is to describe the duration of analgesia in children undergoing surgical correction of idiopathic scoliosis.Design: Retrospective chart review.Setting: Pediatric hospital within a tertiary care academic medical center.Participants: Forty-four pediatric patients with idiopathic scoliosis who received IT morphine following posterior spi

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Vincenty, Claudio, Brian Malone, Mali Mathru, and Bahman Venus. "COMPARISON OF INTRATHECAL AND INTRAVENOUS MORPHINE IN POST CORONARY BYPASS SURGERY." Critical Care Medicine 13, no. 4 (1985): 308. http://dx.doi.org/10.1097/00003246-198504000-00071.

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Abboud, T. K., A. Dror, P. Mosaad, et al. "Mini-Dose Intrathecal Morphine for the Relief of Post-Cesarean SectionPain." Anesthesia & Analgesia 67, no. 2 (1988): 137???143. http://dx.doi.org/10.1213/00000539-198802000-00006.

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Jewett, GA, D. Yavin, P. Dhaliwal, T. Whittaker, J. Krupa, and S. Du Plessis. "Intrathecal morphine in lumbar spine surgery: a novel injection technique." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 42, S1 (2015): S49—S50. http://dx.doi.org/10.1017/cjn.2015.222.

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Background: Intrathecal morphine (ITM) is an efficacious method of providing post-operative analgesia. Despite adoption in many surgical fields, ITM has yet to become a standard of care in lumbar spine surgery. This may in part be attributed to concerns over precipitating a cerebrospinal fluid (CSF) leak following dural puncture. Methods: The dural sac is penetrated obliquely at a 30° angle to prevent overlap of dural and arachnoid puncture sites. Oblique injection in instances of limited dural exposure is made possible by introducing a 60° bend to a standard 30-gauge needle. Participating spi

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Wojcikiewicz, Thomas G., John Jeans, Anil Karmali, Jackline Nkhoma, Jonathan Cousins, and Michael Kynoch. "The use of high-dose intrathecal diamorphine in laparoscopic bariatric surgery: a single-centre retrospective cohort study." British Journal of Pain 13, no. 2 (2018): 106–11. http://dx.doi.org/10.1177/2049463718800521.

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Introduction: The use of intrathecal diamorphine is not commonplace in laparoscopic bariatric surgery. At our institution, a major UK bariatric centre, high-dose intrathecal diamorphine is routinely utilised. Methods: Data were analysed retrospectively. Fifty-three patients who had a spinal anaesthetic were matched against age, sex, body mass index and surgical procedure type to generate controls. Pain scores were recorded in the post-anaesthetic care unit on arrival, after 1 hour and on discharge to the ward. Post-operative nausea and vomiting; post-operative hypertension; pruritus; 24-hour m

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Moisa, Ramona Celia, Nicoleta Negrut, Iulia Codruta Macovei, Cezar Cristian Mihai Moisa, Harrie Toms John, and Paula Marian. "The Impact of Fentanyl and Morphine on Maternal Hemodynamics in Spinal Anesthesia for Cesarean Section." Pharmaceuticals 18, no. 3 (2025): 392. https://doi.org/10.3390/ph18030392.

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Background: Spinal anesthesia is considered the method of choice for elective cesarean sections; however, it is not without maternal–fetal risks. Materials and Methods: This study compared the effects on maternal hemodynamics of intrathecal administration of fentanyl or morphine in parturients undergoing spinal anesthesia with 0.5% hyperbaric bupivacaine, with doses varied between 7.5 and 11 mg, depending on the patient’s height. Data from a cohort of 170 parturients were analyzed. The administered doses were intrathecal morphine at 0.1 mL (100 µg, solution of 1 mg/mL) or fentanyl at 0.25 mL (

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Canakci, Ebru, and Ilker Coskun. "Comparison of ultrasound-guided genicular block vs. intrathecal morphine for postoperative analgesia in patients undergoing knee arthroplasty: A randomised prospective study." Challenge Journal of Perioperative Medicine 1, no. 2 (2023): 32. http://dx.doi.org/10.20528/cjpm.2023.02.003.

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Aim: Total knee arthroplasty (TKA) is a major orthopedic surgical procedure often necessitating effective postoperative analgesia. This study aimed to compare the analgesic efficacy of ultrasound-guided genicular block (GB) and intrathecal morphine (ITM) in patients undergoing THA under spinal anesthesia.Method: A prospective, randomized, single-blind study was conducted at Ordu University Training and Research Hospital from October 1, 2022, to April 1, 2023. Eligible patients aged 18 to 90 undergoing knee surgery with spinal anesthesia were randomized into two groups: Group ITM received intra

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Abboud, T. K., A. Dror, P. Mosaad, et al. "Mini-Dose Intrathecal Morphine for the Relief of Post-Cesarean Section Pain." Anesthesiology 67, no. 3 (1987): A464. http://dx.doi.org/10.1097/00000542-198709001-00464.

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Trivedi, Darshan, Harsha Patel, and Prachi Kunal Shah. "The Evaluation of Intrathecal Morphine for Post Operative Analgesia in Vaginal Hysterectomy." Journal of Medical Thesis 1, no. 1 (2013): 14–16. http://dx.doi.org/10.13107/jmt.2347-5595/007.

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Abboud, T. K., A. Dror, P. Mosaad, et al. "Mini-Dose Intrathecal Morphine for the Relief of Post-Cesarean Section Pain." Obstetric Anesthesia Digest 8, no. 4 (1989): 199. http://dx.doi.org/10.1097/00132582-198901000-00043.

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Shetty, Dr Vijaya Kiran, Dr Vikas Gupta, and Dr Kiran Kumar Shetty. "Epidural or intrathecal morphine for post-operative analgesia following laparoscopic endometriosis surgery." International Journal of Medical Anesthesiology 5, no. 3 (2022): 27–32. http://dx.doi.org/10.33545/26643766.2022.v5.i3a.358.

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Strugnell, Nathan, Jamie Young, Elizabeth Williams, and Bernhard Riedel. "Intrathecal Morphine for Colorectal Cancer Surgery: Immediate Postoperative and Post-Discharge Outcomes." Avicenna Journal of Pharmaceutical Research 3, no. 2 (2022): 63–68. http://dx.doi.org/10.34172/ajpr.1079.

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Background: Colorectal cancer is a major cause of morbidity and mortality in Australia. Following colorectal cancer surgery, although systemic opioids are often first-line analgesia, they may be associated with various adverse effects. Intrathecal morphine (ITM) has been shown to provide good analgesia with a safe side effect profile. This study assessed whether ITM alongside patient-controlled analgesia (PCA) reduces the incidence of immediate postoperative adverse effects and post-discharge outcomes compared to PCA alone following colorectal cancer surgery. Methods: In this retrospective coh

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Tat, Quy L., Srdjan M. Joksimovic, Kathiresan Krishnan, Douglas F. Covey, Slobodan M. Todorovic, and Vesna Jevtovic-Todorovic. "Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels." Cells 9, no. 12 (2020): 2674. http://dx.doi.org/10.3390/cells9122674.

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Preemptive management of post-incisional pain remains challenging. Here, we examined the role of preemptive use of neuroactive steroids with activity on low-voltage activated T-type Ca2+ channels (T-channels) and γ-aminobutyric acid A (GABAA) receptors in the development and maintenance of post-incisional pain. We use neuroactive steroids with distinct effects on GABAA receptors and/or T-channels: Alphaxalone (combined GABAergic agent and T-channel inhibitor), ECN (T-channel inhibitor), CDNC24 (GABAergic agent), and compared them with an established analgesic, morphine (an opioid agonist witho

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