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Dissertations / Theses on the topic 'Post-transcriptional gene regulation'

Author: Grafiati

Published: 4 June 2021

Last updated: 21 February 2023

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1

Hayden, Celine. "Post-Transcriptional Gene Regulation in Plants." Diss., Tucson, Arizona : University of Arizona, 2006. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1684%5F1%5Fm.pdf&type=application/pdf.

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2

Martins, Rute Isabel Paulo. "Post-transcriptional regulation of HFE gene expression." Doctoral thesis, FCT - UNL, 2010. http://hdl.handle.net/10362/5596.

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Thesis presented to obtain the Ph.D. degree in Biology (Molecular Genetics), by the Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia.<br>O ferro é um elemento essencial em diversos processos metabólicos celulares. O desafio que se coloca para a maioria dos organismos prende-se com o controlo do ferro absorvido de modo a suprir as necessidades destes processos evitando, no entanto, os danos causados pelo ferro livre. Na realidade, algumas das doenças humanas mais comuns estão relacionadas com a perturbação da homeostase do ferro. Entre estas, encontra-se a hemocromatose hereditár

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3

Mavropoulos, Athanasios. "Post-transcriptional regulation of interferon-Î³ gene expression." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415673.

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4

Jones, Christopher Iain. "Post-transcriptional gene regulation by the exoribonuclease pacman." Thesis, University of Brighton, 2011. https://research.brighton.ac.uk/en/studentTheses/ff276681-fead-45e4-842f-df0c3a44cfce.

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The gene pacman (pcm) in Drosophila melanogaster encodes the exoribonuclease XRN1, which is highly conserved across eukaryotes and is the only known cytoplasmic exoribonuclease that degrades RNA in the 5’ – 3’ direction. Hypomorphic mutations to pacman have previously been shown cause developmental phenotypes, particularly during wing and thorax development. The focus of this thesis was twofold. Firstly, to create a null pacman allele and associated control lines to further characterise the phenotypes of pcm. Two new alleles were created, one of which was amorphic (pcm14). pcm14 is 100% lethal

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5

Begbie, Megan Elaine. "Transcriptional and post-transcriptional regulation of the human factor VIII gene." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0021/NQ45262.pdf.

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6

Liu, Jun-Li. "Transcriptional and post-transcriptional regulation of somatostatin gene expression by glucocorticoids." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28826.

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Glucocorticoids and somatostatin both influence a broad spectrum of biological activities and their actions are cooperative in growth control, pancreatic islet function, immune suppression, and stress response, e.g. in vivo studies indicate that glucocorticoids may act through somatostatin to suppress growth, growth hormone secretion and inflammation. Recent studies have suggested that glucocorticoids influence somatostatin production but the precise nature of this effect has remained unclear. In this thesis, I characterized the actions of glucocorticoids on somatostatin gene expression and th

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7

Brown, Naomi Jane. "Post-transcriptional regulation of the pea plastocyanin gene (PetE)." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597002.

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Expression of the pea plastocyanin gene (<i>PetE</i>) is regulated both by light and by signals from the chloroplast. Previous work has indicated that the light and chloroplast-controlled regulation operates post-transcriptionally in transgenic tobacco, requiring the correct 5’ terminus of the transcript and elements within the plastocyanin-coding region. The post-transcriptional light and chloroplast-controlled regulation of pea <i>PetE</i> has now been demonstrated to operate in transgenic <i>Arabidopsis</i> plants, indicating that the regulation is conserved in an additional plant species.

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8

Jia, Tao. "Stochastic Modeling of Gene Expression and Post-transcriptional Regulation." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/28483.

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Stochasticity is a ubiquitous feature of cellular processes such as gene expression that can give rise to phenotypic differences for genetically identical cells. Understanding how the underlying biochemical reactions give rise to variations in mRNA/protein levels is thus of fundamental importance to diverse cellular processes. Recent technological developments have enabled single-cell measurements of cellular macromolecules which can shed new light on processes underlying gene expression. Correspondingly, there is a need for the development of theoretical tools to quantitatively model stochast

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9

Rozanska, Agata. "Regulation of post-transcriptional gene expression in human mitochondria." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2706.

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Mitochondria are cellular organelles that have evolved from the eubacterial ancestor into highly specialized compartment of the eukaryotic cell. They are unique among animal cells in that they retain a level of autonomy through the genetic information in their genome. Human mtDNA is built of ~16.5 kbp encoding 13 polypeptides, which are synthesised by mitoribosomes. The latter consist of two RNA species also transcribed from mtDNA and approximately 80 proteins originating from the nucleus. All 13 products of intramitochondrial translation are incorporated into the inner mitochondrial membrane

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10

Elgamal, Ola A. "TRANSCRIPTIONAL AND POST TRANSCRIPTIONAL REGULATION OF GENE EXPRESSION: APPLICATIONS TO BIOLOGY AND CANCER." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461071345.

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11

Panjaworayan, Nattanan, and n/a. "Post-transcriptional regulation of gene expression in Hepatitis B virus." University of Otago. Department of Biochemistry, 2007. http://adt.otago.ac.nz./public/adt-NZDU20071218.143835.

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Hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma and liver cirrhosis worldwide. HBV vaccination can prevent new infections, but effective antiviral drugs are not available for a large number of HBV infected patients. To develop novel antiviral drugs, a better understanding of the regulation of HBV gene expression is vital. One important aspect is to understand how HBV hijacks the cellular machinery to export unspliced RNAs from the nucleus of a cell to the site of incorporation into new HBV particles. The HBV post-transcriptional regulatory element (HBV PRE) is

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12

Jan, Calvin H. "Diverse RNA processing pathways important for post-transcriptional gene regulation." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/65169.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2010.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student submitted PDF version of thesis. Vita.<br>Includes bibliographical references.<br>Cis-acting elements in 3' untranslated regions (UTRs) of mRNAs are crucial to the regulation of gene expression. Animal microRNAs (miRNAs) each target hundreds of mRNAs, which are recognized by pairing to nucleotides 2-7 of the miRNA. MicroRNAs mature through se

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13

Mayhew, Michael. "Coding regions under non-coding selection: implications for transcriptional and post-transcriptional gene regulation." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21995.

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The signals that facilitate transcriptional and post-transcriptional gene expression regulation are still being understood. Comparative genomics approaches based on the premise that sequence or structure conservation implies functionality have successfully distinguished true regulatory sequences and structures from prediction noise. Protein-coding regions of genes have often been overlooked as potential regulatory sequence regions. A set of 8785 coding region sequences were previously found to be conserved significantly above a baseline protein-coding conservation level. We call these sequence

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14

Almlöf, Tova. "Gene regulation by the glucocorticoid receptor : post-DNA binding mechanisms of transcriptional activation /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2675-1.

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15

Janga, Sarath Chandra. "Exploiting network-based approaches for understanding gene regulation and function." Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/236171.

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It is increasingly becoming clear in the post-genomic era that proteins in a cell do not work in isolation but rather work in the context of other proteins and cellular entities during their life time. This has lead to the notion that cellular components can be visualized as wiring diagrams composed of different molecules like proteins, DNA, RNA and metabolites. These systems-approaches for quantitatively and qualitatively studying the dynamic biological systems have provided us unprecedented insights at varying levels of detail into the cellular organization and the interplay between differen

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16

Söderberg, Malin. "Post-Transcriptional Regulation of the Murine Inducible Nitric Oxide Synthase Gene." Doctoral thesis, Uppsala University, Department of Pharmaceutical Biosciences, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6137.

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<p>Large amounts of nitric oxide (NO) are produced by the inducible nitric oxide synthase (iNOS) upon inflammatory stimuli. NO is a multifaceted molecule, which may have beneficial effects as an antimicrobial agent in the immune defense, or cytotoxic effects in chronic inflammations, manifested as e.g. arthritis and asthma. Understanding the mode of regulation of the iNOS gene is a prerequisite for developing intervention strategies in various pathological conditions where detrimental effects of NO need to be prevented.</p><p>Transcriptional processes of the iNOS gene regulation are well descr

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17

Söderberg, Malin. "Post-transcriptional regulation of the murine inducible nitric oxide synthase gene /." Uppsala : Acta Universitatis Upsaliensis: Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6137.

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18

Preiss, Thomas. "Cytochrome c oxidase : a model system for post-transcriptional gene regulation." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281705.

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19

Allen, Margaret Louise. "Post-transcriptional regulation of expression of the potassium channel, Kv1.1 /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/6264.

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20

Lawler, Katherine Joanne. "Transcriptional and post-transcriptional regulation of gene expression : computational analysis of microarray studies in fungal species." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608593.

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21

Sawicka, Kirsty J. "Post-transcriptional regulation of gene expression by the polypyrimidine tract binding protein." Thesis, University of Nottingham, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537674.

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22

Diaz, Manisha Regina. "Regulation of virulence gene expression by Rsm homologs in Pseudomonas aeruginosa." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/4612.

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Pseudomonas aeruginosa RsmA belongs to the CsrA family of RNA binding proteins. CsrA family members are post-transcriptional regulators of global gene expression and usually function to inhibit translation of target genes, but in some cases can also exert positive regulatory effects. Previous work from our lab determined that RsmA is required for maximal T3SS gene expression in P. aeruginosa strain PA103. Nevertheless, the molecular mechanism underlying the RsmA-mediated control of T3SS gene expression was unknown. Expression of the T3SS is under the direct control of ExsA, a transcriptional a

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23

Richardson, Jonathan Paul. "Post-transcriptional regulation of gene expression by the (PSI) prion of Saccharomyces cerevisiae." Thesis, University of Aberdeen, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395144.

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Termination of protein synthesis in the yeast <I>Saccharomyces cerevisiae </I>occurs when the eukaryotic release factor eRF1 recognises the stop codon. The rate of termination is enhanced by a second release factor, eRF3 (a GTPase). The efficiency of stop codon recognition by eRF1 is influenced by the surrounding nucleotide context of the stop codon, and in yeast, by the structural properties of eRF3, which displays prion-like characteristics. eRF3 in the [<I>PSI</I><sup>+</sup>], prion state forms insoluble high molecular weight aggregates that cause inefficient termination (nonsense suppress

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24

Warner, Matthew John. "Mechanisms of post-transcriptional gene regulation in the developmental programming of adulthood disease." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610291.

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25

Peterson, Maureen. "Transposon Regulation: Control of Expression in Drosophila Melanogaster and Consequences of Disregulation in Human Cells." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/203469.

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Transposons were first discovered as "jumping genes" by Barbara McClintock, who continued to study them in maize through the 1940's and 1950's. Since then, transposons have been shown to make up a large percentage of eukaryotic genomes, including close to half of the human genome, but have been dismissed as simply "junk DNA." Recently, the importance of keeping transposons tightly regulated within the cellular environment has begun to be appreciated; the mechanisms to accomplish this have been studied and the current understanding of pathways governing transposon regulation is discussed wi

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26

Yaman, Ibrahim. "Mechanisms of Post-transcriptional Regulation of Cat-1 Gene Expression by Amino Acid Starvation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1120145927.

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27

Oberstrass, Florian Christophe. "Novel modes of protein-RNA recognition in post-transcriptional gene regulation studied by NMR spectroscopy." kostenfrei kostenfrei, 2007. http://e-collection.ethbib.ethz.ch/view/eth:30123.

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28

Ciriello, Simona [Verfasser], and Niels H. [Akademischer Betreuer] Gehring. "Separate functions of BTZ during post-transcriptional gene regulation / Simona Ciriello. Gutachter: Niels H. Gehring." Köln : Universitäts- und Stadtbibliothek Köln, 2014. http://d-nb.info/1069985805/34.

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29

Cheng, Wu Albert. "Epigenetic and post-transcriptional regulation of gene expression in pluripotent stem cells, differentiation and metastasis." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/91122.

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Thesis: Ph. D., Massachusetts Institute of Technology, Computational and Systems Biology Program, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Transmission of information from DNA to RNA to protein underlies the core of modem life forms. The advance in sequencing and genetic technologies has revolutionized the study of molecular biology, genetics and developmental biology enabling delineation of biological processes in unprecedented details. Through the study of epigenetics and posttranscriptional regulation of gene expression by high-throughput seq

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30

Deveau, Laura M. "Characterizing the Disorder in Tristetraprolin and its Contribution to Post-Transcriptional Gene Regulation: A Dissertation." eScholarship@UMMS, 2016. http://escholarship.umassmed.edu/gsbs_diss/855.

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RNA-binding proteins (RBPs) are important for a wide variety of biological processes involved in gene regulation. However, the structural and dynamic contributions to their biological activity are poorly understood. The tristetraprolin (TTP) family of RBPs, including TTP, TIS11b and TIS11d, regulate the stability of mRNA transcripts encoding for key cancer-related proteins, such as tumor necrosis factor- and vascular endothelial growth factor. Biophysical studies have shown that the RNA binding domain, consisting of two CCCH zinc fingers (ZFs), is folded in the absence of RNA in TIS11d and TI

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31

Miller, Ian, and Christopher Pritchett. "A Stem-Loop Secondary Structure Influencing Expression Of The Post-Transcriptional Regulator, RsmA, In Pseudomonas aeruginosa." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/76.

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Pseudomonas aeruginosa is an infectious Gram-negative bacillus that is found in environments ranging from aerobic to anaerobic, soil to water, plant tissues to human tissues, and even found thriving on plastics and medical implant devices. P. aeruginosa is a major concern for individuals who have cystic fibrosis, chronic obstructive pulmonary disorder, diabetes, have recently undergone surgery, have recently experienced severe burns, or have experienced other ailments that resulted in a compromised immune system, such as Human Immunodeficiency Virus (HIV). P. aeruginosa evades the host immune

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32

Rehage, Nina Beate [Verfasser], and Vigo [Akademischer Betreuer] Heissmeyer. "Screening for cofactors in Roquin-mediated post-transcriptional gene regulation / Nina Beate Rehage ; Betreuer: Vigo Heissmeyer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/114485752X/34.

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33

Victor, Xylophone Vijai Aasee. "Angiotensin II-mediated Regulation of the Human Angiotensin II Type 1 Receptor Gene." Diss., CLICK HERE for online access, 2005. http://contentdm.lib.byu.edu/ETD/image/etd952.pdf.

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34

Carlile, Mark. "Post-transcriptional regulation of the npt2-gene locus in Zebrafish and mouse by a natural antisense transcript." Thesis, University of Newcastle upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506431.

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35

Rapone, Roberta. "Essential cytoplasmic role(s) of the histone lysine methyltransferase Setdb1 in post-transcriptional regulation of gene expression." Thesis, Université de Paris (2019-....), 2019. https://theses.md.univ-paris-diderot.fr/RAPONE_Roberta_va.pdf.

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Setdb1 est une «histone» lysine méthyltransférase (KMT) appartenant à la famille SUV39, l’une des principales machineries épigénétiques de répression des gènes. Setdb1 établit notamment la mono-, la di- et la tri- méthylation sur la lysine 9 de l'histone H3 (H3K9).Setdb1 est essentiel pour la survie, la pluripotence et l'auto-renouvellement des cellules souches embryonnaires de souris (mESCs); son knock-out est mortel au stade de la péri-implantation à 3,5 dpc chez la souris. Setdb1 est également nécessaire pour la différenciation de nombreux types de cellules progénitrices : spermatogenèse, n

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36

Leung, Tsz-ki, and 梁子騏. "Transcriptional and post-translational regulations of junctional adhesion molecule-c in mouse germ cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43571992.

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37

Paul, Priyanka. "TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF TERPENOID INDOLE ALKALOID BIOSYNTHESIS IN CATHARANTHUS ROSEUS." UKnowledge, 2017. http://uknowledge.uky.edu/pss_etds/94.

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Catharanthus roseus (Madagascar periwinkle) is the exclusive source of an array of terpenoid indole alkaloids (TIAs) that are used in the treatments of hypertension and certain types of cancer. TIA biosynthesis is under stringent spatiotemporal control and is induced by jasmonate (JA) and fungal elicitors. Tryptamine, derived from the indole branch, and secologanin from the iridoid branch are condensed to form the first TIA, strictosidine. Biosynthesis of TIA is regulated at the transcriptional level and several transcription factors (TFs) regulating the expression of genes encoding key enzyme

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38

Boland, Andreas [Verfasser], and Thilo [Akademischer Betreuer] Stehle. "Structural characterization of eukaryotic mRNA decay factors involved in post-transcriptional gene regulation / Andreas Boland ; Betreuer: Thilo Stehle." Tübingen : Universitätsbibliothek Tübingen, 2014. http://d-nb.info/1163235474/34.

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39

Jeltsch, Katharina [Verfasser], and Daniel [Akademischer Betreuer] Krappmann. "Role of post-transcriptional gene regulation by Roquin in T cell activation and differentiation / Katharina Jeltsch. Betreuer: Daniel Krappmann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1082504866/34.

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40

Kronbeck, Nina Isabella [Verfasser], and Vigo [Akademischer Betreuer] Heissmeyer. "Analyzing cooperative post-transcriptional gene regulation by Roquin in the prevention of autoimmunity / Nina Isabella Kronbeck ; Betreuer: Vigo Heissmeyer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1216039151/34.

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41

McCue, Andrea D. "Transposable element RNAi goes beyond post-transcriptional silencing: mRNA-derived small RNAs both regulate genes and initiate DNA methylation." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437481732.

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42

Moore, Jocelyn. "Post-transcriptional control of Drosophila pole plasm component, germ cell-less." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115700.

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Mechanisms of post-transcriptional control are critical to deploy RNAs and proteins asymmetrically to a discrete region of cytoplasm at the posterior of the Drosophila oocyte and embryo, called the pole plasm and thus allow differentiation of the germline. Research presented in this thesis investigates the post-transcriptional control of Drosophila pole plasm component germ cell-less (gcl ). Maternal gcl activity is required for germ cell specification and gcl RNA and protein accumulate asymmetrically in the pole plasm. gcl RNA, but not Gcl protein, is also detected in somatic regions of the e

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43

Alvarez-Saavedra, Matias Alberto. "MicroRNA-132-Dependent Post-Transcriptional Regulation of Clock Entrainment Physiology Via Modulation of Chromatin Remodeling and Translational Control Gene Targets." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28722.

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Mammalian circadian rhythms of behaviour are synchronized to external time by daily resetting of the master pacemaker, the suprachiasmatic nucleus (SCN), in response to light, in a process known as light-induced clock entrainment. microRNA-132 (miR-132) is induced by light within the SCN via a MAPK-CREB-dependent mechanism and has the capacity to attenuate the entraining effects of light. However, the identity of the genes that miR-132 regulates and their roles in the light-entrainment process have not yet been characterized. This thesis describes that 2 gene clusters involved in chromatin rem

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44

Natalin, Pavel. "Post-transcriptional gene regulation in Drosophila an investigation into the roles of RNA silencing and the DEAD-box helicase Belle /." [S.l. : s.n.], 2009. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-89391.

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Duggimpudi, Sujitha Smruthy [Verfasser]. "Elucidating the physiological function of the RNA binding protein EWS and its role in post-transcriptional gene regulation / Sujitha Smruthy Duggimpudi." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2015. http://d-nb.info/1080298142/34.

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46

Mohamed, Farida Y. "The mechanism(s) of post-transcriptional regulation of the human constitutive endothelial nitric oxide synthase gene by tumor necrosis factor-alpha." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0014/NQ59215.pdf.

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47

Zagore, Leah Louise. "The Molecular Function of the RNA Binding Protein DAZL in Male Germ Cell Survival." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1575647143675768.

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48

Sweet, Thomas Jeffrey. "New Insights Into the Relationship Between Messenger RNA Translation and Degradation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1321298653.

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Hallal, Samantha. "Characterisation of the zinc fingers of Erythroid Kruppel-Like Factor." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/4030.

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Gene expression is known to be regulated at the level of transcription. Recently, however, there has been a growing realisation of the importance of gene regulation at the post-transcriptional level, namely at the level of pre-mRNA processing (5’ capping, splicing and polyadenylation), nuclear export, mRNA localisation and translation. Erythroid krüppel-like factor (Eklf) is the founding member of the Krüppel-like factor (Klf) family of transcription factors and plays an important role in erythropoiesis. In addition to its nuclear presence, Eklf was recently found to localise to the cytoplasm

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50

Hallal, Samantha. "Characterisation of the zinc fingers of Erythroid Kruppel-Like Factor." University of Sydney, 2008. http://hdl.handle.net/2123/4030.

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Doctor of Philosophy (PhD)<br>Gene expression is known to be regulated at the level of transcription. Recently, however, there has been a growing realisation of the importance of gene regulation at the post-transcriptional level, namely at the level of pre-mRNA processing (5’ capping, splicing and polyadenylation), nuclear export, mRNA localisation and translation. Erythroid krüppel-like factor (Eklf) is the founding member of the Krüppel-like factor (Klf) family of transcription factors and plays an important role in erythropoiesis. In addition to its nuclear presence, Eklf was recently found

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