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Dissertations / Theses on the topic 'Post translational modification (PTM)'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Dumont, Quentin. "Applications of Ion Mobility Mass Spectrometry - Screening for SUMOylation and Other Post-Translational Modifications." University of Toledo / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1345130293.

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2

Matsumiya, Nozomi. "Optimization of disulfide mapping using mass spectrometry." Thesis, Kansas State University, 2009. http://hdl.handle.net/2097/1358.

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Master of Science<br>Biochemistry<br>John Tomich<br>One of the important keys to characterize the biological function of a protein is the study of post-translational modification (PTM). Formation of disulfide bond linkages between cysteine residues within a protein is a common PTM which not only contributes to folding and stabilizing the protein structure, but also to accomplishing its native function. Therefore, the study and discovery of structural-functional relationships of expressed proteins using an isolated proteomics approach has been one of the biggest advances within the field of s

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3

Diallo, Issa. "Nouvelle méthode en protéomique pour améliorer l'identification et la quantification des protéines acétylées." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAS035.

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L'acétylation des protéines constitue l’une des plus importantes modifications post-traductionnelles (PTMs). Elle intervient dans de multiples processus bologiques et physiopathologiques tels que, l’activité transcriptionnelle, l'apoptose, la régulation des voies métaboliques, les cancers, les maladies inflammatoires et cardiovasculaires. Face à l’importance de l’acétylation des protéines, il apparaît donc indispensable de bien comprendre les mécanismes qui y sont associés, et donc, de pouvoir identifier et quantifier les protéines acétylées à partir du protéome complet d’échantillons complexe

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4

Schiller, Rachel Shamo. "Investigating the inhibitor and substrate diversity of the JmjC histone demethylases." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:1e7fd2a1-a9c3-48f7-8fa7-a041299d42f9.

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Epigenetic control of gene expression by histone post-translational modifications (PTMs) is a complex process regulated by proteins that can 'read', 'write' or 'erase' these PTMs. The histone lysine demethylase (KDM) family of epigenetic enzymes remove methyl modifications from lysines on histone tails. The Jumonji C domain (JmjC) family is the largest family of KDMs. Investigating the scope and mechanisms of the JmjC KDMs is of interest for understanding the diverse functions of the JmjC KDMs in vivo, as well as for the application of the basic science to medicinal chemistry design. The work

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5

Gopalswamy, Mohanraj [Verfasser]. "Aggregation and post-translational modification of the parathyroid hormone and its agonistic activity towards the G-protein coupled PTH receptors / Mohanraj Gopalswamy." Halle, 2017. http://d-nb.info/1141177951/34.

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6

Dedieu, Alain. "Exploration des modifications post-traductionnelles des protéines : nouvelles approches et nouveaux modèles biologiques." Thesis, Montpellier 1, 2014. http://www.theses.fr/2014MON13516/document.

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L'étude des modifications post-traductionnelles a connu au cours des dernières années un regain d'intérêt notable. Tout d'abord car elle s'effectue aujourd'hui au travers d'approches basées sur la spectrométrie de masse, technique qui pendant cette période a connu de profonds bouleversements, conduisant à des études plus aisées et systématiques.Mais aussi car tant par leur variété que par le rôle qu'elles jouent dans la vie et la régulation cellulaire, ces modifications ne peuvent plus être négligées. Par ailleurs au cours de ces quinze dernières années, nous avons assisté concernant les proca

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7

Gibson, Matthew D. "Reading the Epigenetic State of Chromatin Alters its Accessibility." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1480534756664384.

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8

Silverman, H. S. "Post-translational modification of mucins." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365785.

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9

Wright, Tom. "Post-translational mutagenesis : radical methods for protein modification." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:774aa93a-489e-4051-aa01-b33781215968.

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The naturally occurring post-translational modification of proteins expands the chemical and structural diversity available for protein function. Enzymatic processes are known to modify proteins after translation, and in many cases these modifications have been demonstrated to be critical for biological function. However, the paucity of methods for introduction of site-specific modifications to proteins remains a key obstacle to their biochemical study. Access to these naturally modified proteins has long been complicated by their low abundance, difficulties in purifying homogeneous samples fr

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10

Inche, Adam. "The post translational modification of the retinoblastoma protein." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491620.

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The retinoblastoma protein (pRb) is a central figure in the control of not only the cell cycle, but also other cellular functions such as differentiation. The regulation of pRb function is through a variety of post translational modifications, either on pRb itself, or by the controlling influence of pRb on the post translational modification of the histone proteins. Phosphorylation of pRb is a key mechanism in the regulation of the cell cycle. pRb is also involved in the recruitment of histone methyltransferase (HMT) and acetyltransferase (HAT) to the chromatin to modify histones. Previous wor

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11

Strong, Emily. "Post translational modification of Exo1 in Saccharomyces cerevisiae." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19163/.

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Meiosis is the cell division that produces haploid gametes for the purpose of sexual reproduction. During this division it is essential for homologous chromosomes to be securely paired and segregated in order for the gametes to receive a single copy of each chromosome. An important protein in this process is the exonuclease Exo1. Exo1 has two important and distinct roles during meiosis: resection of DNA at double-strand breaks (DSBs) exposing single stranded DNA suitable for strand invasion, and resolution of double-Holliday junctions (dHJs) as cross-overs. Exo1 also acts as a nuclease during

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12

Svensson, Nilsson Caroline. "Post-translational modification of protein kinase RNA-activated." Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-355076.

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13

Filipe, Soares Renata. "Proteomic analysis of post-translational modification of streptococcal proteins." Thesis, King's College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618344.

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14

Boulanger, Marie-Chloé. "Arginine methylation, the characterization of a post-translational modification." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85889.

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Proteins are known to be post-translationally modified. This thesis will discuss arginine methylation, one of the many post-translational modifications that occur within the cell. The enzymes that catalyze this post-translational modification are called arginine methyltransferases. The three main types of methylated arginines include monomethylated arginine (MMA), asymmetric dimethylated arginine (aDMA) and symmetric dimethylated arginines (sDMA). Type I arginine methyltransferases catalyze the formation of MMA and aDMA; Type II enzyme catalyze the formation of MMA and sDMA. Protein arg

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15

Lupi, Rosita. "Characterization of post translational modification of heterotrimeric G proteins." Thesis, Open University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343748.

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16

Pasquel, Danielle R. "Regulation of Pregnane X Receptor by Post-translational Modification." Thesis, Yeshiva University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10019210.

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<p> Pregnane X receptor (PXR) is a major transcriptional regulator of xenobiotic metabolism and transport pathways in the liver and intestines, which are critical for protecting organisms against potentially harmful xenobiotic and endobiotic compounds. Inadvertent activation of drug metabolism pathways through PXR is known to contribute to drug resistance, adverse drug-drug interactions, and drug toxicity in humans. In both humans and rodents, PXR has been implicated in non-alcoholic fatty liver disease, diabetes, obesity, inflammatory bowel disease, and cancer. Because of PXR's important func

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17

Chapman, Tajekesa Kudzaishe Pamacheche. "Regulation of PABP1 function by differential post-translational modification." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25875.

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Post-transcriptional control of gene expression is critical for normal cellular function and viability. Poly(A)-binding protein (PABP) 1 is the prototypical member of a family of RNA-binding proteins which are key post-transcriptional regulators. PABP1 is multifunctional, acting as a primary determinant of translation efficiency and mRNA stability, regulating the fate of specific mRNAs, and participating in microRNAmediated regulation and nonsense-mediated mRNA decay. As well as binding various mRNAs, PABP1 achieves its multifunctionality through protein-protein interactions with numerous PABP

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18

Leocadio-Victoria, Daniel. "Post-translational modification and nuclear targeting of beta-dystroglycan." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/9316/.

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Cellular communication and the link between the extracellular and intracellular environments are in part mediated by signalling events from plasma membrane proteins. Their tight regulation by a diverse array of post-translational modifications (PTM) is essential to maintain the cellular integrity. Understanding these modifications would help with understanding cancer cell progression. Dystroglycan is one of the plasma membrane proteins with both structural and signalling properties, and is a core component of the dystrophin associated protein complex (DAPC). The nuclear localisation of dystrog

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19

Perez, Morales Tiara G. "SdpAB are required for post-translational modification of SdpC." Thesis, University of Iowa, 2010. https://ir.uiowa.edu/etd/577.

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Bacillus subtilis is a Gram-positive spore-forming soil bacterium. Under environmental stress conditions such as starvation, B. subtilis enters the pathway of sporulation. Earlier work demonstrated that B. subtilis can delay sporulation by undergoing cannibalism. Sporulating cells secrete toxins that kill nearby siblings, thus allowing cells to feed on the released contents. One of these toxins, SdpC, is encoded by the sdpABC operon. To uncover the requirements for SdpC toxic activity during cannibalism, all proteins in the sdpABC operon were analyzed. We report that mutations of SdpC which bl

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20

Beswick, H. T. "Post-translational modification of lens proteins in relation to cataract." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354818.

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21

Alsaadi, Reham. "Characterization of Post-Translational Modification of ATG16L1 in Antibacterial Autophagy." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39151.

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Autophagy is a highly regulated catabolic pathway that is potently induced by stressors including starvation and infection. An essential component of the autophagy pathway is an ATG16L1-containing E3-like enzyme, which is responsible for lipidating LC3B and driving autophagosome formation. ATG16L1 polymorphisms have been linked to the development of Crohn’s disease (CD) and phosphorylation of CD-associated ATG16L1 (caATG16L1) has been hypothesized to contribute to cleavage and autophagy dysfunction. Here we show that ULK1 kinase directly phosphorylates ATG16L1 in response to infection and s

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22

Charvet, Casey Douglas. "Post-Translational Modification By Isolevuglandins: Retinal Detection, Effects, and Prevention." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1366296569.

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23

Bentley-DeSousa, Amanda. "Investigating Polyphosphate Biology: From Post-Translational Modification to Rare Disease." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42225.

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The first report of polyphosphates (polyP) was in 1890 by L. Liberman and since then, polyP’s role in biology has been explored. PolyPs are chains of phosphoanhydride-linked inorganic phosphates ranging from 3-1000s of units in length. These chains are implicated in many cellular pathways including blood clotting, bacterial virulence, and neuroproteotoxic disease. Given the diversity of polyP, they make an excellent candidate in the development of novel therapeutics. In yeast, polyP is synthesized by the vacuolar transporter chaperone (VTC) complex as a translocation event into the vacuole lum

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24

Abraham, Jacinth. "Post-translational modification of p53 protein in response to DNA damage." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0027/NQ49932.pdf.

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25

Hurley, Christopher James. "Regulation of the transcription factor Neurogenin 3 by post-translational modification." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607900.

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26

Yang, Yujie. "POST-TRANSLATIONAL MODIFICATION AND DEGRADATION MECHANISMS OF THE ARYL HYDROCARBON RECEPTOR." Scholarly Commons, 2021. https://scholarlycommons.pacific.edu/uop_etds/3753.

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The aryl hydrocarbon receptor (AHR) is a transcription factor first discovered to be activated by exogenous ligands, such as dioxins, and helps promote downstream gene (e.g. CYP1A1) transcription to metabolize the toxicants. With the reports of various AHR targets genes, the expression levels and activities of AHR have been implicated in many physiological and pathological situations. Understanding how AHR protein level is regulated would provide more information to target AHR. AHR stays in the cytosol in the absence of ligand in a complex with HSP90, p23 and XAP2. After ligand activation, AHR

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27

Murnan, Eric Joseph. "Post-translational modification and regulation of the chaperone Hsp27 during apoptosis." Connect to resource, 2009. http://hdl.handle.net/1811/37289.

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28

Freschi, Luca. "Post-translational modifications regulatory networks : evolution, mechanisms et implications." Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/25812.

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Les modifications post-traductionnelles (PTM) sont des modifications chimiques des protéines qui permettent à la cellule de réguler finement ses fonctions ainsi que de coder et d’intégrer des signaux environnementaux. Les progrès récents en ce qui a trait aux techniques expérimentales et bioinformatiques nous ont permis de determiner les profils de PTM pour des protéomes entiers ainsi que d’identifier les molécules qui sont responsables d’ « écrire » ou d’« effacer » ces PTM. Avec ces donnés, il a été possible de commencer à definir des réseaux de régulation cellulaire par PTM. Ici, nous avons

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29

Hertlein, Erin K. "Post-translational modification of NF-kappaB regulation of stability and gene expression /." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1167336380.

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30

Abdelghany, Magdy Korashy. "Profiling post translational modification of histone and p53 in human breast carcinomas." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/12234/.

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Breast cancer is one of the most common cancers in females in the western world, and despite the advances in diagnosis and treatment it is still associated with significant morbidity. Thus, improvements to existing treatment modalities remain a priority. Understanding the molecular mechanisms controlling tumour growth and its modulation will be key to developing new therapies. In recent years it has been shown that posttranslational modifications (PTMs) of histones and p53 are functionally important in the regulation of cellular processes such as proliferation, differentiation and DNA damage r

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31

Hertlein, Erin K. "Post-translational modification of NF-kB: regulation of stability and gene expression." The Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=osu1167336380.

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32

Hozoji, Masako. "Post-translational modification and regulation of ABCA1 involved in cellular cholesterol homeostasis." Kyoto University, 2009. http://hdl.handle.net/2433/126528.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第14842号<br>農博第1782号<br>新制||農||974(附属図書館)<br>学位論文||H21||N4482(農学部図書室)<br>27248<br>UT51-2009-F484<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田和光, 教授阪井康能, 教授三芳秀人<br>学位規則第4条第1項該当

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33

Brewster, Richard Christian. "Development of Halomethyl-Triazole reagents for installation of protein post-translational modification mimics." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31116.

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Triazoles have been widely used as amide bond isosteres in chemical biology as linkers and to enhance proteolytic stability. The use of triazoles has grown exponentially since the discovery of the copper (I) catalysed alkyne azide cycloaddition reaction in 2002 as the reaction is solvent and functional group tolerant, and usually high yielding. The reaction is also orthogonal to reactions used in nature, meaning it has become a powerful coupling tool. In post-translational modification (PTM), proteins are modified by covalent attachment of functional groups to amino acid side chains. These PTM

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34

Wingrove, Callum Scott. "Post-translational modifications of recombinant human interferon-#gamma# in the CHO 320 cell line." Thesis, University of Kent, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357687.

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35

Hoffman, Michael David. "Method development for the comprehensive analysis of post translational modifications by mass spectometry." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1051.

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Signal Transduction is mediated by protein complexes whose spatial- and temporal-distribution, composition and function within cells are often regulated by different post-translational modifications (PTM). As PTMs add or subtract a specific mass difference to a protein, mass spectrometry becomes very amenable for modification analysis. These modifications have conventionally been monitored by fragmenting the modified protein or peptide by collision induced dissociation (CID) within the mass spectrometer, and then screening for the characteristic neutral fragment or fragment ion (marker ion), w

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36

Keller, Patrick. "Developmental regulation and post-translational modification of lactase-phlorizin hydrolase and sucrase-isomaltase /." [S.l.] : [s.n.], 1994. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10881.

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37

Thatte, Jayashree. "The role of post translational modification in regulating Human Papillomavirus (HPV) E6 functions." Thesis, Open University, 2018. http://oro.open.ac.uk/58133/.

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The Human Papillomavirus (HPV) E6 oncoprotein from cancer-causing HPV types is highly multi-functional, capable of targeting many different cellular partners and pathways. Integral to this multi-functionality is its regulation by phosphorylation. Here I describe studies to firstly investigate when E6 is phosphorylated within the PDZ binding motif (PBM), and demonstrate a complex pattern of phosphorylation events which take place upon the exposure of the cells to different forms of stress. Most important of which is phosphorylation by kinases belonging to the core of the DNA Damage Response (DD

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38

Humbard, Matthew Adam. "Post-translational modification and the 20S proteasome system of the haloarchaeon Haloferax volcanii." [Gainesville, Fla.] : University of Florida, 2009. http://purl.fcla.edu/fcla/etd/UFE0024797.

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39

Li, Xiang. "Post-translational modification and sequestration of cAMP-specific phosphodiesterase 4 in signalling complexes." Thesis, University of Glasgow, 2006. http://theses.gla.ac.uk/39014/.

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cAMP is a ubiquitous second messenger that is pivotal in controlling a wide array of cellular functions. The sole means to inactivate cAMP is to degrade it into 5'- AMP through the action of cyclic nucleotide phosphodiesterases (PDEs). It is now well appreciated that cAMP hydrolysis by PDEs is as important as its synthesis by adenylyl cyclases to achieve cAMP homeostasis in cells. The cAMP-specific phosphodiesterase-4 (PDE4) is encoded by four different genes (PDE4A, PDE4B, PDE4C and PDE4D), which generate over 16 different isoforms by alternative 5' mRNA splicing. This process gives rise to P

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40

Liu, Qingbin. "Post-translational modification on arginine and function of CCAAT/enhancer binding protein alpha." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16620.

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Der Transkriptionsfaktor CCAAT/enhancer-binding protein α (C/EBPα) kontrolliert Zellzyklusarrest und terminale Differenzierung von neutrophilen Granulozyten und Adipozyten. Mutationen von C/EBPα treten häufig im Zusammenhang mit akuter myeloischer Leukämie auf. Massenspektrometrische Untersuchungen zeigten, dass C/EBPα an mehreren konservierten Argininen citrunilliert ist, einschließlich R297 in der C-terminalen basischen Region von C/EBPα. Mutationen von C/EBPα R297 wurden bereits beschrieben, weshalb der Schwerpunkt dieser Arbeit auf die Analyse der Modifikation dieses Aminosäurereste

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41

Liu, Ling, and 刘凌. "Regulation of post-translational modifications of the protein kinase LKB1: molecular mechanisms and physiologicalimplications." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47660831.

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Background and objectives: Endothelial dysfunction and cancer are two of the important aspects of obesity-related medical complications, the prevalence of which is reaching an epidemic level worldwide. The protein kinase LKB1 has been shown to play opposite roles in these two metabolic diseases by promoting cellular senescence and inhibiting cell proliferation through regulating a series of its downstream targets. However, the molecular mechanisms wherebyLKB1 itself is regulated by its upstream molecules remains poorly understood. The major objectives of this study are to identify novel u

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42

Gabant, Guillaume. "Spectrométrie de masse des modifications induites ou post-traductionnelles de protéines : méthodologie et application à des protéines d’intérêt thérapeutique." Thesis, Orléans, 2014. http://www.theses.fr/2014ORLE2061/document.

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Les modifications de protéines, qu’elles soient post-traductionnelles (PTMs) ou induites chimiquement, ont une influence considérable sur l'activité des protéines. Des méthodes de spectrométrie de masse (MS) HRMS, MS/MS CID et ETD, et de biochimie ont été développées pour la caractérisation structurale et cinétique de complexes protéine-ligand et de PTMs, dans le but de disséquer leur mécanisme et de concevoir des médicaments covalents contre des protéines liant des protéases, des kinases, ou l'ADN. La MS combinée avec des outils biochimiques a permis de séquencer l'inhibiteur de protéases gré

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43

Liu, Serena E. B. "Kinome-wide RNAi Screening to Identify Kinases Involved in Post-translational Modification of FUS." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34199.

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Amyotrophic lateral sclerosis (ALS) is a devastating adult onset neurodegenerative disorder characterized by the selective degeneration of upper and lower motor neurons. Patients typically die from respiratory failures within 2-5 years after diagnosis. One of the milestones in ALS research is the discovery Fused in Sarcoma (FUS), an ALS causative gene. FUS is an RNA/DNA-binding protein and predominantly resides in the nucleus. Majority of the FUS mutations are located in the C-terminus and causing aberrant misdistribution to the cytoplasm. Currently, only a few binding partners of FU

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44

Lakshmi, Sreeja [Verfasser], and Eugen [Akademischer Betreuer] Kerkhoff. "Post-translational modification and regulation of human Spir protein / Sreeja Lakshmi. Betreuer: Eugen Kerkhoff." Regensburg : Universitätsbibliothek Regensburg, 2011. http://d-nb.info/1023276283/34.

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45

Nixon, Benjamin R. "Effect of Post-translational Modification Crosstalk on Thin Filament Regulatory Function in Cardiac Muscle." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397558646.

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46

Liddy, Kiersten Alexandra. "A Post-Translational Investigation into the Molecular Basis for Preconditioning in the Rat Myocardium." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16189.

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Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Cell death associated with myocardial infarction can be significantly decreased using a number of preconditioning strategies. These include short, consecutive periods of ischaemia (ischaemic preconditioning; IPC), pharmacological agents (pPC) and ischaemic preconditioning of another organ (remote ischaemic preconditioning; rIPC) prior to an ischemia / reperfusion (IR) event. Molecular mechanisms underlying cardioprotection remain unknown. This thesis presents a comparative phosphoproteomic examination of cell sig

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47

Zhou, Shanggen. "Post-translational regulation of CCAAT/enhancer binding protein [delta] (C/EBP[delta]) by ubiquitin family proteins." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1195227986.

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48

Liu, Li. "Purification and characterization of a protein palmitoyltransferase that acts on H-Ras protein and on a C-terminal N-Ras peptide /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/8664.

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49

Kesic, Matthew J. "Identification and characterization of the post-translational modifications of the HTLV types 1 and 2 regulatory protein Rex." Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1241104210.

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Lens, Zoé. "Sumo et le désordre structural font-ils bon ménage ?" Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210023.

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Abstract:

La sumoylation représente, après l’ubiquitination, l’exemple le plus étudié de modification post-traductionnelle impliquant la liaison d’une protéine à une autre. Cependant, alors que l’ubiquitination est impliquée principalement dans la dégradation des protéines par le protéasome, la sumoylation semble réguler les propriétés biochimiques de ses substrats (localisation cellulaire, interaction protéique, activité, …). Pour venir lier une protéine appelée Sumo (Small Ubiquitin-like Modifier) sur un substrat, la sumoylation emprunte une voie enzymatique analogue à celle de l’ubiquitination mais u

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