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Dissertations / Theses on the topic 'Postnatal neurogenesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 March 2023

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1

Ozen, Ilknur. "Neurogenin2, a molecular marker of postnatal hippocampal neurogenesis." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612424.

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2

Lin, Chia-Wei. "Activity-dependent integration and plasticity of new neurons during postnatal neurogenesis." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/61877.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Most neurons are born during the embryonic period to become the building blocks for a variety of brain circuits. However, two brain regions only start to assemble during the postnatal period. Both brain areas, olfactory bulb and dentate gyrus, mainly accommodate the integration of new neurons during the postnatal period, and continuously receive new neurons throughout animals' life. In this thesis, I used the ra

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3

Namaka, Michael Peter. "The discovery of precursor cells and neurogenesis in postnatal dorsal root sensory ganglia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0011/NQ53049.pdf.

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4

Winpenny, Eleanor Margaret. "Embryonic and postnatal glutamatergic neurogenesis of the olfactory bulb : the role of Neurogenin2." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609142.

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5

Wong, Kwong-kwan, and 黃廣堃. "MicroRNA expression profiling in neurogenesis of neural stem cells from postnatal to young adult rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47770533.

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MicroRNAs are short RNA molecules composed of 20-22 nucleotides. They highly accurately indicate cell identity and hence they are useful in labeling cells and tacking lineage commitment. However, this requires accurate microRNA profiling of cells in individual developmental stages. Since microRNAs are important negative regulators of eukaryotic gene expression, microRNA profiling allows better understanding of molecular regulatory networks of important cellular events, such as adult neurogenesis. Adult neurogenesis is the process in which neurons, as well as glia, are generated from ne

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6

Erasso, Diana Marcela. "Differential Effects of Isoflurane and Propofol Anesthesia on Neurogenesis in Young and Aged Rats." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3092.

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Worldwide, millions of young and elderly patients receive procedures that could not be performed without the use of anesthetics. Unfortunately, emerging animal and human data suggest an association between exposure to general anesthesia and impairment of cognitive function in pediatric and geriatric patients. Recent laboratory data have shown that general anesthetics are potentially damaging to the developing and aging brain. However, the mechanism by which this happens is still unknown. General anesthetics affect learning and memory, a brain function involving neural plasticity. An important

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7

Pellegrino, Giuliana. "Cell neogenesis in the postnatal hypothalamus as a new mechanism of control of the reproductive function." Thesis, Lille 2, 2017. http://www.theses.fr/2017LIL2S042.

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Malgré sa complexité, le cerveau intègre en permanence de nouvelles cellules – à la fois neuronales et gliales – au-delà du développement embryonnaire et ce, tout le long de la vie. La période postnatale est caractérisée par une gliogenèse intense. A l’âge adulte, de nouveaux neurones et cellules gliales sont produits dans des régions restreintes à partir de cellules souches/progénitrices (CSP) localisées dans des niches. Les deux niches de CSP adultes les mieux décrites sont la zone sous-ventriculaire des ventricules latéraux, qui produit de nouveaux interneurones olfactifs, et la zone sous-g

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8

Bolz, Marianne. "Régulation du destin cellulaire pendant la neurogénèse postnatale : rôle de l'innervation dopaminergique issue du mésencéphale." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4098.

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Le cerveau des mammifères abrite deux régions spécifiques où la neurogenèse adulte ne cesse pas après l'embryogenèse, mais persiste dans le cerveau postnatal et adulte. Ces deux régions sont la zone sous-granulaire du gyrus denté de l’hippocampe et la zone sous-ventriculaire (SVZ) des ventricules latéraux.Dans la SVZ, des cellules souches neurales génèrent des neuroblastes qui migrent jusqu’au bulbe olfactif (OB) pour coloniser les couches granulaires et glomérulaires et se différencier en différent types d’interneurones dont une petite fraction sont des interneurones dopaminergiques. La décou

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9

Abuawad, Mohammad. "Pathological changes in Alexander disease : a comparative study in human and mice with GFAP mutations." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC296.

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La maladie d'Alexander est une maladie neurodégénérative due à des mutations hétérozygotes du gène GFAP codant le principal filament intermédiaire des astrocytes matures. Nous avons étudié l'effet des mutations GFAP dans l'hippocampe d'un patient avec AxD infantile et de deux souris knockin, l'une portant une mutation dans le rod domain (p.R85C) et l'autre dans le tail domain (p.T409I). Chez le patient, nous décrivons pour la première fois: (i) des changements morphologiques sévères des cellules GFAP+ dans la zone subgranulaire du gyrus denté, qui ont perdu la plupart de leurs processus radiau

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10

Serrano, Céline. "Etude de l’apprentissage et de la mémoire spatiale à long terme après une exposition postnatale du cerveau ou du gyrus denté dorsal, à des doses faibles à modérées de rayonnements ionisants : rôle de la neurogenèse hippocampique adulte." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASQ008.

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Les effets d’une exposition cérébrale à des doses faibles à modérées de rayonnements ionisants (RIs) sur la cognition des adultes exposés pendant leur enfance ne sont pas clairement établis chez l’Homme et un manque de données expérimentales existe à ce sujet. Toutefois, les études menées à fortes doses nous rapportent que l’irradiation (IR) de l’hippocampe (HPC), un des lieux de neurogenèse adulte, semble jouer un rôle dans l’apparition des troubles cognitifs à l’âge adulte. Dans cette thèse, nous avons étudié et comparé les effets d’une irradiation postnatale du cerveau entier (CV) ou du gyr

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11

Chang, Eun Hyuk. "The role of polycomb repressive complex 2 in postnatal subventricular zone neural stem/progenitor cell self-renewal and multipotency." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:1ddbd108-0256-4a4a-b40a-35818197ca39.

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The murine subventricular zone (SVZ) in a brain contains a population of stem cells and daily produces tens of thousands of neurons throughout lifetime. However, the mechanisms of SVZ neural stem/progenitor cell (NSPC) maintenance, differentiation and cell-fate specification are still not clear. To understand these parameters via histone methylations with bivalent mechanism, the SVZ NSPCs were first isolated by using a culture technique called neurosphere assay (NSA). It has been a challenge to culture pure cell populations of SVZ subtypes, so the NSA was initially validated. The H3K27me3 mark

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12

Hofstetter, Katharina Melanie [Verfasser]. "Analyse von postnataler Neurogenese in transgenen Mäusen mit einer Vorderhirn-spezifischen, konstitutiv aktiven FoxO3 Mutante / Katharina Hofstetter." Ulm : Universität Ulm, 2017. http://d-nb.info/1123646171/34.

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13

Hofstetter, Katharina [Verfasser]. "Analyse von postnataler Neurogenese in transgenen Mäusen mit einer Vorderhirn-spezifischen, konstitutiv aktiven FoxO3 Mutante / Katharina Hofstetter." Ulm : Universität Ulm, 2017. http://d-nb.info/1123646171/34.

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14

Al, Dalahmah Osama Ahmad Odeh. "The molecular regulation of neural stem cell lineage progression in the postnatal subventricular zone by Galectin-3." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:cb9020e1-931f-44cd-8409-7d2c58817d6e.

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Neurogenesis continues postnatally in two major neural stem cell (NSC) niches: The subventricular zone (SVZ) and dentate gurus of the hippocampus. SVZ NSCs self-renew and produce transit amplifying progenitor cells that, in turn, divide and give rise to neuroblasts. These neuroblasts migrate to the olfactory bulbs, via the rostral migratory stream (RMS), where they terminally differentiate into mature neurons. The postnatal SVZ (pSVZ) is more gliogenic than its adult counterpart (aSVZ), contributing to robust postnatal astrocytogenesis and oligodendrogenesis in the surrounding brain parenchyma

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15

Cavallin, Mara. "Physiopathologie moléculaire et cellulaire des anomalies du développement du cortex cérébral : le syndrome d'Aicardi WDR81 mutations cause extreme microcephaly and impair mitotic progression in human fibroblasts and Drosophila neural stem cells TLE1, a key player in neurogenesis, a new candidate gene for autosomal recessive postnatal microcephaly Mutations in TBR1 gene leads to cortical malformations and intellectual disability Aicardi syndrome: Exome, genome and RNA-sequencing of a large cohort of 19 patients failed to detect the genetic cause Recurrent RTTN mutation leading to severe microcephaly, polymicrogyria and growth restriction Recurrent KIF2A mutations are responsible for classic lissencephaly Recurrent KIF5C mutation leading to frontal pachygyria without microcephaly Rare ACTG1 variants in fetal microlissencephaly De novo TUBB2B mutation causes fetal akinesia deformation sequence with microlissencephaly: An unusual presentation of tubulinopathy A novel recurrent LIS1 splice site mutation in classic lissencephaly Further refinement of COL4A1 and COL4A2 related cortical malformations Prenatal and postnatal presentations of corpus callosum agenesis with polymicrogyria caused By EGP5 mutation Delineating FOXG1 syndrome from congenital microcephaly to hyperkinetic encephalopathy Delineating FOXG1 syndrome: From congenital microcephaly to hyperkinetic encephalopathy." Thesis, Sorbonne Paris Cité, 2019. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2213&f=18201.

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Les malformations du cortex cérébral (MDC) représentent une cause importante de handicap et d'épilepsie pharmaco-résistante. Le séquençage à haut débit a permis une amélioration considérable de l'identification des bases moléculaires des MDC non syndromiques. Toutefois, certaines formes, notamment les MDC complexes, demeurent inexpliquées. Mon projet de thèse a pour objectif de progresser dans la compréhension des MDC complexes en utilisant deux modèles : les microlissencéphalies (MLIS) et le syndrome d'Aicardi (AIC), une forme syndromique particulière associant des malformations de l'oeil et

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16

McClelland, Christine R. "Cux2 regulates neurogenesis in the postnatal mouse hippocampus." Thesis, 2012. http://hdl.handle.net/10222/15237.

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Although once thought to be incapable of regeneration, the adult mammalian brain generates new neurons in two regions: the SVZ of the lateral ventricle and the DG of the hippocampus. While the cell types involved in adult neurogenesis have been broadly characterized, the transcriptional regulation of this process remains poorly understood. Here, we demonstrate that transcription factor Cux2 is important for normal postnatal hippocampal neurogenesis. Cux2neo/neo mutant mice generated fewer Dcx-positive neuroblasts, Tbr2-positive transit amplifers, and Calretinin-positive immature neurons, witho

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17

Seah, Carol, and 謝佳瞜. "Postnatal Neurogenesis in Three Species of Bats in Taiwan." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/65911567884754049935.

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碩士<br>國立臺灣師範大學<br>生命科學研究所<br>102<br>Postnatal neurogenesis occurs in mammals throughout life. Neural stem cells (NSCs) in the subventricular zone (SVZ) of the lateral ventricle and in the subgranular zone (SGZ) of the dentate gyrus (DG) give rise to new neurons in the olfactory bulb (OB) and DG, respectively. Newborn neurons can establish synaptic connections and integrate into the neural circuit. Most of the studies focus on molecular mechanisms of postnatal neurogenesis in captive animals, especially lab rodents. However, whether it also persists in wild mammals is not fully elucidated. Bats

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18

Pino, Annachiara. "Meningeal cells contribute to cortical neurogenesis in postnatal brain." Doctoral thesis, 2016. http://hdl.handle.net/11562/936154.

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La neurogenesi nel cervello dei mammiferi prosegue durante il corso di tutta la vita (Eriksson et al., 1998; Gage, 2000) in due nicchie germinative: la zona sottoventricolare e il giro dentato dell’ippocampo (Gage and Temple, 2013). Le cellule della glia radiale (Kriegstein and Alvarez-Buylla, 2009) sono le cellule staminali che, durante lo sviluppo embrionale e postnatale, danno origine a diversi tipi cellulari tra cui neuroblasti, neuroni, oligodendrociti, astrociti e cellule ependimali (Kriegstein and Alvarez-Buylla, 2009). Oltre a queste nicchie di cellule staminali ampiamente caratterizz

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19

Huang, Yin Cheng, and 黃盈誠. "Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/28528192503823282473.

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博士<br>長庚大學<br>臨床醫學研究所<br>97<br>Stem cells are defined to have the capability of self-renewal, proliferation and differentiation. In mammals, subventricular zone (SVZ) is a neural stem niche where thousands of neuroblasts are born everyday and migrate to the olfactory bulb (OB). There are a few signals pathways reported to be involved in this neurogenic niche; epigenetic control is a one of the major mechanisms remained to be elucidate. Chromatin remodelling, a key process to activate or suppress gene function, is important for stem cell maintenance. However, for neural stem cells, the relation

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20

Moreira, João Baptista. "Modulation of Subventricular Zone Postnatal Neurogenesis: Actions of Exercise-Regulated Neurotrophic Factors and Cannabinoid Type 2 Receptor." Master's thesis, 2019. http://hdl.handle.net/10316/88078.

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Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia<br>O cérebro adulto, apesar de ser maioritariamente constituído por células pós-mitóticas, é reconhecido por ter células estaminais neurais (NSCs) que tanto se podem diferenciar em neurónios como em glia. De facto, a neurogénese ocorre de forma constitutiva principalmente em dois nichos neurogénicos distintos, a zona subventricular (SVZ), ao longo das paredes laterais dos ventrículos laterais, e a zona subgranular (SGZ), no giro dentado (DG) do hipocampo, onde as NSCs se diferenciam em novo

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21

Wei-HuaWang and 王瑋樺. "Induction of anxious behavior in rats and hippocampal neurogenesis-related gene expression after postnatal exposure to valproic acid." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/26283193480664942772.

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碩士<br>國立成功大學<br>生命科學系碩博士班<br>101<br>Valproic acid (VPA) is a widely used medicine to treat or prevent epilepsy and bipolar disorder. However, exposure to valproate during pregnancy causes behavioral impairments, like cognitive delay, social interaction, anxious behaviors and interests which is related to symptoms of autistic spectrum disorder. The molecular mechanism remains largely unknown. In our laboratory, we used the model of male rat pups receiving 200 mg/kg of VPA by intraperitoneal injection (ip) at postnatal day 7 (P7). The results from elevated plus-maze test at 2,4 and 6 weeks post

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22

Ribeiro, Ana Filipa Ferreira da Cunha 1987. "Unveiling the trophic actions of adenosine A2A receptors in neurite outgrowth and postnatal neurogenesis : interaction with brain-derived neurotrophic factor." Doctoral thesis, 2017. http://hdl.handle.net/10451/32688.

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Tese de doutoramento, Ciências Biomédicas (Neirociências), Universidade de Lisboa, Faculdade de Medicina, 2017<br>In the postnatal mammalian brain, neurogenesis occurs constitutively in two main regions: in the subventricular zone (SVZ) of the lateral ventricles and in the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG). These neurogenic niches are postnatal sources of new neurons that functionally integrate into the existing circuitry. SVZ future neurons migrate long distances through the rostral migratory stream (RMS) towards the olfactory bulb (OB), whilst SGZ future neurons mi

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23

TSENG, CHING-SAN, and 曾慶三. "The Role of Cytoplasmic Polyadenylation Element Binding Protein 4 in the Regulation of Early Postnatal Neurogenesis and Olfactory Bulb Development." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/m548h7.

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博士<br>國防醫學院<br>生命科學研究所<br>106<br>Mammalian olfactory bulbs (OBs) require continuous replenishment of interneurons, mainly granule cells (GCs), to support local circuits throughout life. Two spatiotemporally distinct waves of postnatal neurogenesis contribute to expanding and maintaining the GC pool. Although neonate-born GCs show higher survival rate than adult-born GCs, the molecular mechanism underlying this survival remains unclear. Here, we identify RNA-binding protein cytoplasmic polyadenylation element-binding protein 4 (CPEB4) as a survival factor exclusively for early postnatal GCs. Du

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