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1

Yang, Yuanxi, Jinlong Li, Junyi Xu, and Jing Tang. "Generalised DOPs with Consideration of the Influence Function of Signal-in-Space Errors." Journal of Navigation 64, S1 (2011): S3—S18. http://dx.doi.org/10.1017/s0373463311000415.

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Integrated navigation using multiple Global Navigation Satellite Systems (GNSS) is beneficial to increase the number of observable satellites, alleviate the effects of systematic errors and improve the accuracy of positioning, navigation and timing (PNT). When multiple constellations and multiple frequency measurements are employed, the functional and stochastic models as well as the estimation principle for PNT may be different. Therefore, the commonly used definition of “dilution of precision (DOP)” based on the least squares (LS) estimation and unified functional and stochastic models will
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2

Fiebrich, H., A. H. Brouwers, M. N. Kerstens, et al. "Sensitivity of 6-[F-18]fluoro-L-dihydroxyphenylalanine positron emission tomography for localizing tumors causing catecholamine excess." Journal of Clinical Oncology 27, no. 15_suppl (2009): 11064. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.11064.

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11064 Background: Positron emission tomography (PET) using the catecholamine precursor 6-[F-18]fluoro-L-dihydroxyphenylalanine (18F-DOPA) has emerged as promising technique to localize tumors with catecholamine excess. This study investigated the sensitivity of 18F-DOPA PET, compared to 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy and computer tomography (CT)/ magnetic resonance imaging (MRI) in patients with catecholamine excess. Methods: In a single center prospective study 18F-DOPA PET was compared to 123I-MIBG and CT/MRI in patients with catecholamine excess. The performance of ea
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Evangelista, Laura, Lea Cuppari, Luisa Bellu, et al. "Comparison Between 18F-Dopa and 18F-Fet PET/CT in Patients with Suspicious Recurrent High Grade Glioma: A Literature Review and Our Experience." Current Radiopharmaceuticals 12, no. 3 (2019): 220–28. http://dx.doi.org/10.2174/1874471012666190115124536.

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Purpose: The aims of the present study were to: 1- critically assess the utility of L-3,4- dihydroxy-6-18Ffluoro-phenyl-alanine (18F-DOPA) and O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) Positron Emission Tomography (PET)/Computed Tomography (CT) in patients with high grade glioma (HGG) and 2- describe the results of 18F-DOPA and 18F-FET PET/CT in a case series of patients with recurrent HGG. Methods: We searched for studies using the following databases: PubMed, Web of Science and Scopus. The search terms were: glioma OR brain neoplasm and DOPA OR DOPA PET OR DOPA PET/CT and FET OR FET PET OR
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Koopmans, Klaas P., Oliver C. Neels, Ido P. Kema, et al. "Improved Staging of Patients With Carcinoid and Islet Cell Tumors With18F-Dihydroxy-Phenyl-Alanine and11C-5-Hydroxy-Tryptophan Positron Emission Tomography." Journal of Clinical Oncology 26, no. 9 (2008): 1489–95. http://dx.doi.org/10.1200/jco.2007.15.1126.

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PurposeTo evaluate and compare diagnostic sensitivity of positron emission tomography (PET) scanning in carcinoid and islet cell tumor patients with a serotonin and a catecholamine precursor as tracers.Patients and MethodsCarcinoid (n = 24) or pancreatic islet cell tumor (n = 23) patients with at least one lesion on conventional imaging including somatostatin receptor scintigraphy (SRS) and computed tomography (CT) scan underwent11C-5-hydroxytryptophan (11C-5-HTP) PET and 6-[F-18]fluoro-L-dihydroxy-phenylalanin (18F-DOPA) PET. PET findings were compared with a composite reference standard deri
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Kao, Chang-Long, Yan-Fu Chen, Ping-Chih Huang, Ching-Yun Hsu, and Chun-Hsiung Kuei. "A facile one-pot synthesis of l-DOPA imprinted silica nanospheres for chiral separation and in vitro controlled release." RSC Advances 5, no. 20 (2015): 15511–14. http://dx.doi.org/10.1039/c4ra16698a.

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6

Vora, Sujay A., Deanna Pafundi, Todd A. DeWees, et al. "Phase II study of short course hypofractionated proton beam therapy incorporating 18F-DOPA-PET/MRI for elderly patients with newly diagnosed glioblastoma." Journal of Clinical Oncology 41, no. 16_suppl (2023): 2002. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.2002.

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2002 Background: Elderly patients with glioblastoma have a poor prognosis with phase III trials reporting median overall survival (OS) and global time to deterioration of 6–9 and 1.2 months respectively. 18F-DOPA (3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine) positron emission tomography (PET) is sensitive and specific for identifying regions of high density and biologically aggressive glioblastoma. Proton beam therapy (PBT) can spare more healthy tissue that may improve quality of life for this patient population. With improved targeting of disease along with dosimetric advantages of PBT, thi
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Kauhanen, Saila, Marko Seppänen, Heikki Minn та ін. "Fluorine-18-l-Dihydroxyphenylalanine (18F-DOPA) Positron Emission Tomography as a Tool to Localize an Insulinoma or β-Cell Hyperplasia in Adult Patients". Journal of Clinical Endocrinology & Metabolism 92, № 4 (2007): 1237–44. http://dx.doi.org/10.1210/jc.2006-1479.

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Abstract Context and Objective: Fluorine-18-l-dihydroxyphenylalanine (18F-DOPA) positron emission tomography (PET) is a promising method in localizing neuroendocrine tumors. Recently, it has been shown to differentiate focal forms of congenital hyperinsulinism of infancy. The current study was set up to determine the potential of 18F-DOPA PET in identifying the insulin-secreting tumors or β-cell hyperplasia of the pancreas in adults. Patients and Methods: We prospectively studied 10 patients with confirmed hyperinsulinemic hypoglycemia and presumed insulin-secreting tumor using 18F-DOPA PET. A
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8

Breen, William, S. Keith Anderson, Deanna Pafundi, et al. "CTNI-28. VOLUMETRIC AND DOSIMETRIC PATTERNS OF FAILURE ANALYSIS OF A PHASE II CLINICAL TRIAL OF 18F-DOPA-PET DIRECTED DOSE ESCALATED RADIOTHERAPY FOR GLIOBLASTOMA." Neuro-Oncology 23, Supplement_6 (2021): vi65. http://dx.doi.org/10.1093/neuonc/noab196.253.

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Abstract While dose escalation of radiotherapy (DERT) has failed to improve overall survival (OS) or progression-free survival (PFS) for glioblastoma in previous studies, a recent phase II clinical trial utilizing 18F-DOPA-PET-directed DERT demonstrated improved PFS in MGMT-unmethylated patients and OS in MGMT-methylated patients compared to historical controls. This planned secondary analysis sought to determine 1) how 18F-DOPA-PET changes RT volumes beyond standard MRI-planning, 2) which patients benefit most and least from this protocol, 3) which are mostly likely to experience clinically s
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9

Prost, Diego Martín, Lucia Nichelli, Laura Rozenblum, et al. "Effect of 18F-DOPA-PET and advanced MRI on treatment response assessment in IDH1/2-mutant gliomas treated with IDH inhibitors." Journal of Clinical Oncology 43, no. 16_suppl (2025): 2050. https://doi.org/10.1200/jco.2025.43.16_suppl.2050.

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2050 Background: Small-molecule inhibitors targeting IDH1/2-mutant proteins (IDHi) have shown promise as treatments for IDH1/2 -mutant gliomas. However, accurate assessment of response using morphological magnetic resonance imaging (MRI) measurements remains difficult, and the potential of PET imaging with radiolabeled amino acids in this context is yet to be explored. Here, we investigated 3,4-Dihydroxy-6-[18F]-fluoro-L-phenylalanine PET (¹⁸F-DOPA-PET) and MRI responses in IDH1/2 -mutant glioma patients receiving IDHi. Methods: IDH1/2 -mutant glioma patients receiving IDHi as part of trials o
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Li, Cong, Chang Yi, Yingshen Chen, et al. "NIMG-18. THE CLINICAL SIGNIFICANCE OF 13N-NH3, 18F-DOPA, AND 18F-FDG PET/CT IN THE DIFFERENTIAL DIAGNOSIS BETWEEN GLIOMA RECURRENCE AND TREATMENT EFFECTS." Neuro-Oncology 22, Supplement_2 (2020): ii150—ii151. http://dx.doi.org/10.1093/neuonc/noaa215.631.

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Abstract BACKGROUND Glioma often recurs and the imaging evaluation whether the tumor has returned after glioma treatment is still challenging. PET/CT is one of the most important techniques to assess the post-treatment of glioma. However, differentiating tumor recurrence (TuR) from treatment effects (TrE) remains difficult. In this study, we aim to retrospectively compare the diagnostic performance of three PET tracers 13N-NH3, 18F-DOPA, and 18F-FDG on PET/CT in differentiating between TuR and TrE in post-treatment glioma patients. METHODS Forty-three patients with MRI-suspected recurrent glio
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11

Tsentr, N. V., and D. V. Ryzhkova. "Optimization of [18F]-DOPA PET/CT Protocol in Patients with Medullary Thyroid Carcinoma: a Prospective Study." Scientific Notes of the Pavlov University 31, no. 4 (2024): 27–33. https://doi.org/10.24884/1607-4181-2024-31-4-27-33.

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Introduction. The method of positron emission tomography combined with X-ray computed tomography (PET/CT) with [18F]-L-dihydroxyphenylalanine ([18F]-DOPA) is the most accurate technique in the detection of tumor tissue in the patients with biochemical relapse of medullary thyroid carcinoma. According to foreign recommendations, the optimal time to [18F]-DOPA PET/CT scanning begin is considered to be an interval of 30–60 minutes after injection of the radiopharmaceutical. However, there are limited publications with a small group of patients that have demonstrated increased sensitivity of [18F]
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12

Mossine, Andrew V., Sean S. Tanzey, Allen F. Brooks, et al. "One-pot synthesis of high molar activity 6-[18F]fluoro-l-DOPA by Cu-mediated fluorination of a BPin precursor." Organic & Biomolecular Chemistry 17, no. 38 (2019): 8701–5. http://dx.doi.org/10.1039/c9ob01758e.

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A one-pot two-step synthesis of 6-[<sup>18</sup>F]fluoro-l-DOPA has been developed, involving Cu-mediated radiofluorination of the corresponding pinacol boronate ester precursor, and validated for production of doses for human use.
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13

Kauhanen, Saila, Marko Seppänen, Jari Ovaska, et al. "The clinical value of [18F]fluoro-dihydroxyphenylalanine positron emission tomography in primary diagnosis, staging, and restaging of neuroendocrine tumors." Endocrine-Related Cancer 16, no. 1 (2009): 255–65. http://dx.doi.org/10.1677/erc-08-0229.

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The study was set up to determine the clinical value of dihydroxyphenylalanine positron emission tomography-computed tomography ([18F]DOPA PET-CT) in patients with neuroendocrine tumors (NETs). Eighty-two patients with suspected/known NET were imaged with PET(-CT) using [18F]DOPA. Patients were divided into two groups: primary diagnosis/staging and restaging of disease. All patients without previous diagnosis of NET had biochemical proof of disease. The diagnostic accuracy of PET was assessed by comparing the histopathology and clinical follow-up. The overall accuracy of [18F]DOPA PET was 90%.
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14

Nanni, C., S. Fanti, and D. Rubello. "18F-DOPA PET and PET/CT." Journal of Nuclear Medicine 48, no. 10 (2007): 1577–79. http://dx.doi.org/10.2967/jnumed.107.041947.

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15

Saini, Amardeep Singh, and Jose Savio Melo. "One-pot green synthesis of eumelanin: process optimization and its characterization." RSC Advances 5, no. 59 (2015): 47671–80. http://dx.doi.org/10.1039/c5ra01962a.

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Herein, we propose the importance of Taguchi’s design of experiment methodology for increasing the yield of eumelanin using l-Dopa as the substrate and tyrosinase enzyme from Amorphophallus campanulatus as the biocatalyst.
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Santy, Karuna Ryan, and Budiman Alvin. "E-dopt: A Mobile Application for Pet Adoption in Indonesia." TELKOMNIKA Telecommunication, Computing, Electronics and Control 16, no. 5 (2018): 2137–43. https://doi.org/10.12928/TELKOMNIKA.v16i5.8074.

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In this research, we discuss the current trend on pet adoption in Indonesia and introduce a mobile application called e-dopt to encourage more pet adoption in Indonesia. Pet adoption mobile application is not yet popular in Indonesia, thus the benefit of conducting this research. Within this research, a mobile application to help the pet adoption process has been developed. The mobile application is developed on Android platform and the requirements are gathered by interviews, surveys, and research that have been conducted. The mobile application developed provides convenience for those who wa
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Mureddu, Michele, Thomas Funck, Giovanni Morana, et al. "A New Tool for Extracting Static and Dynamic Parameters from [18F]F-DOPA PET/CT in Pediatric Gliomas." Journal of Clinical Medicine 13, no. 20 (2024): 6252. http://dx.doi.org/10.3390/jcm13206252.

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Background/Objectives: PET imaging with [18F]F-DOPA has demonstrated high potential for the evaluation and management of pediatric brain gliomas. Manual extraction of PET parameters is time-consuming, lacks reproducibility, and varies with operator experience. Methods: In this study, we tested whether a semi-automated image processing framework could overcome these limitations. Pediatric patients with available static and/or dynamic [18F]F-DOPA PET studies were evaluated retrospectively. We developed a Python software to automate clinical index calculations, including preprocessing to delineat
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Qian, Jing, Deanna Pafundi, William Breen, et al. "RADT-15. 18F-DOPA PET/CT SURVEILLANCE FOR GLIOBLASTOMA: A RADIOMIC MODEL FROM A PROSPECTIVE PHASE II CLINICAL TRIAL PREDICTING SURVIVAL IN IDH-WILDTYPE, MGMT-UNMETHYLATED PATIENTS." Neuro-Oncology 24, Supplement_7 (2022): vii52. http://dx.doi.org/10.1093/neuonc/noac209.205.

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Abstract BACKGROUND Interpretation of serial magnetic resonance imaging (MRI) for glioblastoma following radiation therapy (RT) is complicated by difficulty differentiating tumor from treatment-related changes, even using updated RANO criteria. The incorporation of novel imaging such as 3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine (18F-DOPA) PET/CT to post-treatment serial imaging may improve prognostication and better facilitate future treatment decisions. METHODS The secondary analysis of a recent phase II prospective clinical trial of 18F-DOPA PET/CT-directed dose-escalated RT included pati
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Hoshi, Hiroaki, Hiroto Kuwabara, Gabriel Léger, Paul Cumming, Mark Guttman, and Albert Gjedde. "6-[18F]fluoro-l-DOPA Metabolism in Living Human Brain: A Comparison of Six Analytical Methods." Journal of Cerebral Blood Flow & Metabolism 13, no. 1 (1993): 57–69. http://dx.doi.org/10.1038/jcbfm.1993.8.

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In 11 normal volunteers and six patients with Parkinson's disease, we compared six different analyses of dopaminergic function with l-3,4-dihydroxy-6-[18F]fluorophenylalanine (FDOPA) and positron emission tomography (PET). The caudate nucleus, putamen, and several reference regions were identified in PET images, using magnetic resonance imaging (MRI). The six analyses included two direct determinations of DOPA decarboxylase activity ( kD3, k*3), the slope–intercept plot based on plasma concentration ( K), two slope–intercept plots based on tissue content ( kr3, ks3), and the striato–occipital
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Manso, Jacopo, Loris Bertazza, Susi Barollo, et al. "Overexpression of miR-375 and L-type Amino Acid Transporter 1 in Pheochromocytoma and Their Molecular and Functional Implications." International Journal of Molecular Sciences 23, no. 5 (2022): 2413. http://dx.doi.org/10.3390/ijms23052413.

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Pheochromocytoma (Pheo) is a tumor derived from chromaffin cells. It can be studied using 18F-dihydroxyphenylalanine (DOPA)—positron emission tomography (PET) due to its overexpression of L-type amino acid transporters (LAT1 and LAT2). The oncogenic pathways involved are still poorly understood. This study examined the relationship between 18F-DOPA-PET uptake and LAT1 expression, and we explored the role of miR-375 and putative target genes. A consecutive series of 58 Pheo patients were retrospectively analyzed, performing 18F-DOPA-PET in 32/58 patients. Real-time quantitative PCR was used to
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Khamis, K., N. Giladi, C. Levine, et al. "The Added Value of 18F-FDOPA PET/CT in the Work-Up of Patients with Movement Disorders." Neurographics 9, no. 5 (2019): 344–48. http://dx.doi.org/10.3174/ng.1900004.

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Movement disorders represent a common clinical feature in many different neurologic diseases. However, although the clinical features are often similar, there are many different possible etiologies of these movement disorders, which represent a valid diagnostic challenge. Management of these patients is dependent on an accurate diagnosis of the underlying etiology because the clinical course and treatment may vary significantly. 18F-Fluor-l-dopa has been used as a positron-emitting compound for PET evaluation of patients with movement disorders and parkinsonism. To emphasize the diagnostic val
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Zschieschang, P., V. Prasad, D. Moskopp, B. Knie, and M. Plotkin. "A family with pheochromocytoma-paraganglioma inherited tumour syndrome." Nuklearmedizin 55, no. 01 (2016): 34–40. http://dx.doi.org/10.3413/nukmed-0755-15-07.

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SummaryAim: Hereditary pheochromocytoma-paraganglioma syndromes are characterized by multiple pheochromocytomas (PCC) and paragangliomas (PGLs), inherited in an autosomal dominant manner. Early detection and removal of tumours may prevent or minimize complications related to mass effects and malignant transformation. Having confirmed the diagnosis, it is important to localize the tumours and reveal their extent preoperatively. This study aimed to introduce 18F-DOPA PET/CT as a highly sensitive noninvasive diagnostic tool for early detection of mass lesions in patients with pheochromocytoma-par
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Burroni, Luca, Andrea Palucci, Giuseppina Biscontini, and Valentino Cherubini. "Early diagnosis of focal congenital hyperinsulinism: A fluorine-18-labeled l-dihydroxyphenylalanine positron emission tomography/computed tomography study." World Journal of Nuclear Medicine 20, no. 04 (2021): 395–97. http://dx.doi.org/10.4103/wjnm.wjnm_159_20.

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AbstractCongenital hyperinsulinism (CHI) is responsible for hyperinsulinemic hypoglycemia which needs aggressive treatment in order to prevent neurological damages. Recent advances in genetics have linked CHI to mutations in many different genes that play a key role in regulating insulin secretion from pancreatic β-cells. Furthermore, histopathological lesions, diffuse and focal, have been associated with these different genetic alterations. This short manuscript describes how the advent of fluorine-18-labeled L-dihydroxyphenylalanine-positron emission tomography/computed tomography (18F-DOPA-
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Michalicha, Anna, Cristina Canal, Albert Espona-Noguera, et al. "Collagen-Sealed Polyester Vascular Prostheses Functionalized by Polycatecholamine Coatings." International Journal of Molecular Sciences 23, no. 16 (2022): 9369. http://dx.doi.org/10.3390/ijms23169369.

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Collagen-sealed polyester (PET) prostheses are commonly used in reconstructive vascular surgery due to their self-sealing properties. To prevent post-surgical infection, different modification methods have been tested but so far none have showed long-term satisfactory efficiency. For this reason, in the present study, a commercial collagen-sealed PET prosthesis was coated by a highly adhesive poly (L-DOPA) layer maintaining the sealing protein without losing the original properties and functionality. This modified (as proven by SEM, FTIR, XPS and contact angle) graft exhibited comparable wetta
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Lange-Nolde, A., T. Zajic, M. Slawik, et al. "PET with 18F-DOPA in the imaging of parathyroid adenoma in patients with primary hyperparathyroidism." Nuklearmedizin 45, no. 05 (2006): 193–96. http://dx.doi.org/10.1055/s-0038-1625218.

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Summary:Preoperative localization of parathyroid adenomas (PA) can shorten operation time and improve curative rate; it becomes especially important in minimally invasive surgical techniques. Aim of this study was to investigate whether positron emission tomography (PET) with 3-,4-dihydroxy- 6-18F-fluorophenylalanine (18F-DOPA), which showed very promising results in other neuroendocrine tumours, also helps to localize PA. Patients, methods: Eight patients with proven primary hyperparathyroidism were studied preoperatively with PET. Seven also underwent scintigraphy with 99mTc-MIBI and ultraso
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Zanzi, Italo, Yana Studentsova, David Bjelke, Richard Warner, Barry Babchyck, and Thomas Chaly. "Fluorine-18-fluorodihydroxyphenylalanine Positron-emission Tomography Scans of Neuroendocrine Tumors (Carcinoids and Pheochromocytomas)." Journal of Clinical Imaging Science 7 (May 22, 2017): 20. http://dx.doi.org/10.4103/jcis.jcis_107_16.

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Objectives: Conventional methods of imaging neuroendocrine tumors with computed tomography, magnetic resonance imaging, indium-111-octreotide, or radiolabeled metaiodobenzilguanidine scintigraphy have limitations. This pilot study tried to improve the localization of these tumors with fluorine-18-fluorodihydroxyphenylalanine (F-DOPA) positron-emission tomography (PET) scanning. Materials and Methods: We studied 22 patients, the majority of whom were referred with clinical diagnosis or suspicion of carcinoid (n = 11), neuroendocrine tumors (n = 7) or pheochromocytoma/paraganglioma (PGL) (n = 4)
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Tsentr, N. V., A. A. Zyryanova, M. A. Rusnak, and D. V. Ryzhkova. "Diagnostic capabilities of PET/CT with <sup>18</sup>F-DOPA in biochemical recurrence of medullary thyroid carcinoma: a retrospective study." Diagnostic radiology and radiotherapy 15, no. 1 (2024): 87–95. http://dx.doi.org/10.22328/2079-5343-2024-15-1-87-95.

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INTRODUCTION: Medullary thyroid carcinoma (MTС) is a rare neuroendocrine malignant neoplasm of the thyroid gland. In most cases, sporadic MTС is diagnosed at late stages due to the absence of specific symptoms. The main method of treatment of MTС is surgical — thyroidectomy and in most cases cervical lymphodissection. Current international guidelines suggest the use of basal calcitonin levels and cancer embryonic antigen (CEA) as markers of biochemical recurrence. In biochemical recurrence of the disease, it is advisable to search for tumor foci regardless of the level of cancer markers. Posit
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Xu, Bo, Shouao Zhu, Siheng Zhao, and Xiangdong Wang. "A High-Phosphorus-Content Polyphosphonate with Combined Phosphorus Structures for Flame Retardant PET." Polymers 15, no. 7 (2023): 1713. http://dx.doi.org/10.3390/polym15071713.

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A high-phosphorus-content polyphosphonate (PBDA), containing two phosphorus-based structures: phosphaphenanthrene (DOPO) and phenyl phosphonate groups, was synthesized and used in flame retardant polyethylene terephthalate (PET). Good self-extinguishing property (high UL 94 grade and LOI value), superior flame retardancy (lower heat/smoke release), and high quality retention (high carbon residue) were endowed to PET by PBDA. When 10 wt% PDBA was added, the peak heat release rate (pHRR), total heat release (THR), and total smoke rate (TSR) of PDBA/PET were found to be significantly reduced by 8
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Todorovic-Tirnanic, Mila, Vera Artiko, Smiljana Pavlovic, Dragana Sobic-Saranovic, and Vladimir Obradovic. "Contemporary nuclear medicine diagnostics of neuroendocrine tumors." Srpski arhiv za celokupno lekarstvo 143, no. 1-2 (2015): 108–15. http://dx.doi.org/10.2298/sarh1502108t.

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The new positron emission tomography (PET/CT) methods for neuroendocrine tumors detection are presented and compared with classic, conventional methods. Conventional methods use a gamma scintillation camera for patients with neuroendocrine tumor imaging, after intravenous injection of one of the following radiopharmaceuticals: 1) somatostatin analogues labeled with indium-111 (111In-pentetreotide) or technetium-99m (99mTc-EDDA/HYNIC-TOC); 2) noradrenaline analogue labeled with iodine-131 or -123 (131I/123I-MIBG); or 3) 99mTc(V)-DMSA. Contemporary methods use PET/CT equipment for patients with
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Zemskova, Marina S., Bhaskar Gundabolu, Ninet Sinaii, et al. "Utility of Various Functional and Anatomic Imaging Modalities for Detection of Ectopic Adrenocorticotropin-Secreting Tumors." Journal of Clinical Endocrinology & Metabolism 95, no. 3 (2010): 1207–19. http://dx.doi.org/10.1210/jc.2009-2282.

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Abstract Context: Because ectopic ACTH-secreting (EAS) tumors are often occult, improved imaging is needed. Objective: Our objective was to evaluate the utility of [111In-DTPA-d-Phe]pentetreotide scintigraphy [octreotide (OCT)] imaging at 6 mCi [low OCT (LOCT)] and 18 mCi [high OCT (HOCT)], [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) and [18F]l-3,4-dihydroxyphenylalanine (F-DOPA)-PET scans, computed tomography (CT), and magnetic resonance imaging (MRI). Design and Setting: The study was a prospective evaluation at a clinical research center. Patients: Forty-one subjects pa
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Priya S, Vishnu, and Somasundaram P. "INDUCED PHENOLOXIDASE PROFILES IN SILKWORM Bombyx mori (L.) UNDER BIOTIC STRESS." International Journal of Engineering Technologies and Management Research 4, no. 10 (2020): 46–52. http://dx.doi.org/10.29121/ijetmr.v4.i10.2017.105.

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Phenol oxidase (PO) is one of the stress enzyme protein in living organism. The conversion of Pro-PO into an activation form of PO required a stress protein. In the present study has emerged with the novel finding of induced phenoloxidase was identified under bacterial endotoxin viz., Lipopolysaccharide (LPS) activity using silkworm Bombyx mori as an animal model. The PO enzyme plays an important role for insect survival during pathophysiological conditions. The enzyme activity was analyzed from ten different silkworm races with two phenolic substrates viz., L-Dopa and Dopamine by Native-PAGE.
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Vishnu, Priya S., and P. Somasundaram. "INDUCED PHENOLOXIDASE PROFILES IN SILKWORM Bombyx mori (L.) UNDER BIOTIC STRESS." International Journal of Engineering Technologies and Management Research 4, no. 10 (2017): 46–52. https://doi.org/10.5281/zenodo.1042479.

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<strong><em>Phenol oxidase (PO) is one of the stress enzyme protein in living organism. The conversion of Pro-PO into an activation form of PO required a stress protein. In the present study has emerged with the novel finding of induced phenoloxidase was identified under bacterial endotoxin viz., Lipopolysaccharide (LPS) activity using silkworm Bombyx mori as an animal model. The PO enzyme plays an important role for insect survival during pathophysiological conditions. The enzyme activity was analyzed from ten different silkworm races with two phenolic substrates viz., L-Dopa and Dopamine by
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Lee, Wen-Lung, Lung-Chang Liu, Chien-Ming Chen, and Jian-Shian Lin. "Syntheses and flame retarding properties of DOPO polymers, melamine polymers, and DOPO-melamine copolymers." Polymers for Advanced Technologies 25, no. 1 (2013): 36–40. http://dx.doi.org/10.1002/pat.3201.

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34

Yang, Yicheng, Yue Lu, Wang Zhan, and Qinghong Kong. "Design of a Novel Chitosan Derivatives and DOPO Flame Retardant and Its Application in Epoxy Resin." Macromol 5, no. 1 (2025): 9. https://doi.org/10.3390/macromol5010009.

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To expand the utilization of bio-based materials as flame retardants in epoxy resin (EP), a green Schiff base structural material (CSV) was synthesized via a one-pot approach employing chitosan and vanillin as the raw materials. Then, the CSV combined with 9,10-dihydro-9-oxa-10-phospha-phenanthrene-10-oxide (DOPO) (the mass ratio between CSV and DOPO was 1:2, written as CSV-DOPO) improved the flame retardancy of the EP. When the amount of CSV−DOPO in the EP was only 3 wt%, the thermogravimetric analysis (TGA) results indicated that the residue of the EP composites was 50.6% higher than that of
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35

Bhat, Vighneshwar S., T. S. Tilakraj, Mallikarjun K. Patil, Vikram Pujari, and Sanjeev R. Inamdar. "One-Pot Synthesis of Biocompatible Glycine Protected Chromium Doped ZnS Nanoparticles and their Optical Properties." IOP Conference Series: Materials Science and Engineering 1221, no. 1 (2022): 012029. http://dx.doi.org/10.1088/1757-899x/1221/1/012029.

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Abstract Here in, we report the synthesis and characterization of Chromium doped Zinc Sulfide nanoparticles (ZnS NPs). Initially, ZnS NPs are synthesized by bio-compatible glycine cap using simple one-pot co-precipitate method, and further it is doped by Chromium. The structure and morphology of these ZnS NPs was confirmed by X-Ray Diffractometry (XRD) and Scanning Electron Microscope with Elementary Dispersive Spectrum (SEM with EDS) techniques. The optical characterization techniques reveal that the Chromium doping affected the absorption and photoluminescence properties of the NPs. Photolum
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Li, Qiaoguang, Xugang Shu, Puyou Jia, and Yonghong Zhou. "Preparation of Biomass-Based Ester End-Capped Hyperbranched Poly(ether)s via Facile One-Pot Reaction and Their Performance as Non-Toxic Plasticizers." Polymers 12, no. 4 (2020): 913. http://dx.doi.org/10.3390/polym12040913.

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The aim of this study was to develop a facile one-pot reaction for the synthesis of biomass-based hyperbranched poly(ether)s end-capped as acetate esters (BHE) for use as a sustainable, safe and feasible plasticizer for flexible poly(vinyl chloride) (PVC) materials. BHE is completely miscible with PVC but shows weaker plasticizing effect than dioctyl phthalate (DOP) (EΔTg value of BHE reaches 64.8%). PVC plasticized with BHE displays greater thermal stability than that of PVC or PVC plasticized with DOP materials. BHE improves the thermal stability and flexibility of PVC materials. As a plasti
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37

Samanta, Suman, Saon Banerjee, Asis Mukherjee, Pulak K. Patra, and Pramiti K. Chakraborty. "Determining the radiation use efficiency of potato using sunshine hour data: a simple and costless approach." Spanish Journal of Agricultural Research 18, no. 2 (2020): e0801. http://dx.doi.org/10.5424/sjar/2020182-15561.

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Aim of study: Radiation parameters and photoperiod influence potato biomass and tuber yield significantly. Lack of instrument facilities in developing countries is the main hindrance to estimate global solar radiation (GSR) and radiation use efficiency (RUE). Considering these facts, an experiment was conducted to estimate light extinction coefficient (K) and RUE using a simple but indirect approach that can be implied in any location lacking sophisticated instruments.Area of study: Field experiments were conducted in Kalyani, West Bengal, representing the Indo-Gangetic Plains.Material and met
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Trébossen, Régine, Bernard Bendriem, Maria-Joao Ribeiro, Anne Fontaine, Vincent Frouin, and Philippe Remy. "Validation of the Three-Dimensional Acquisition Mode in Positron Emission Tomography for the Quantitation of [18F]Fluoro-DOPA Uptake in the Human Striata." Journal of Cerebral Blood Flow & Metabolism 18, no. 9 (1998): 951–59. http://dx.doi.org/10.1097/00004647-199809000-00004.

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Three-dimensional (3D) positron emission tomography (PET) is attractive for [18F]fluoro-DOPA studies, since the sensitivity improvement is maximal for radioactive sources located in central planes, which is usually the case for the human striata. However, the image quantitation in that mode must be assessed because of the nearly threefold increase in scattered coincidences. We report the results of [18F]fluoro-DOPA studies performed on six normal volunteers. Each one was scanned in the 3D and two-dimensional(2D) modes on the same tomograph. The quantitation in the 3D and 2D modes was compared
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Yue, Lipei, Yingjie Cao, Tong Huang, Lei Huang, Yongping Bai, and Yongfeng Zhou. "Synthesis of Aromatic Hyperbranched Polyester (HBPE) and its Use as a Nonmigrating Plasticiser." Australian Journal of Chemistry 67, no. 1 (2014): 22. http://dx.doi.org/10.1071/ch13195.

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A series of aromatic hyperbranched polyesters (HBPEs) were synthesised through one-pot reaction of benzene-1,2,4-tricarboxylic anhydride, diethylene glycol, and methanol. The molecular structure of HBPEs was characterised by 1H-NMR, Fourier transform infrared spectroscopy, gel permeation chromatography, differential scanning calorimetry (DSC), and thermogravimetric analysis. HBPE was used as plasticiser for poly(vinyl chloride) (PVC), and compared with traditional plasticiser bis(2-ethylhexyl) phthalate (DOP). When the plasticiser concentration in PVC was below 40 wt-%, HBPE showed better plas
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40

Snow, B. J., H. Takahashi, Poppy Schofield, et al. "L-18F-DOPA-PET bei Parkinson-Plus-Syndromen zum Nachweis einer gestörten präsynaptischen dopaminergen Funktion." Nuklearmedizin 31, no. 02 (1992): 43–47. http://dx.doi.org/10.1055/s-0038-1629599.

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ZusammenfassungBei 14 Patienten mit Parkinson-Plus-Syndromen (PPLUS) wurden PET-Unter- suchungen mittels L-18F-DOPA unter Verwendung einer arteriellen Inputfunktion durchgeführt. Aufgrund von Modellannahmen konnte für den radioaktiven Tracer die Influxkonstante Ki in Abhängigkeit von Korrekturen der unspezifischen Aktivität im Kortex oder Zerebellum bestimmt werden. Die Ergebnisse wurden mit denen von 20 gesunden Kontrollen verglichen und im Hinblick auf die Intra- und Interuntersucher-Variabilität ausgewertet. Bei Patienten mit Parkinson-Plus-Syndromen war in allen Fällen die Influxkonstante
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Lopci, Egesta, Arnoldo Piccardo, Cristina Nanni, et al. "18F-DOPA PET/CT in Neuroblastoma." Clinical Nuclear Medicine 37, no. 4 (2012): e73-e78. http://dx.doi.org/10.1097/rlu.0b013e3182485172.

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42

Chondrogiannis, Sotirios, Maria Cristina Marzola, and Domenico Rubello. "18F-DOPA PET/Computed Tomography Imaging." PET Clinics 9, no. 3 (2014): 307–21. http://dx.doi.org/10.1016/j.cpet.2014.03.007.

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43

Tsentr, N. V., A. E. Ertman, and D. V. Ryzhkova. "PET/CT with various radiopharmaceuticals in the complex diagnosis of medullary thyroid carcinoma: a review." Diagnostic radiology and radiotherapy 14, no. 2 (2023): 31–41. http://dx.doi.org/10.22328/2079-5343-2023-14-2-31-41.

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INTRODUCTION: Medullary carcinoma is a rare malignant neuroendocrine tumor of the thyroid gland. Medullary thyroid carcinoma (MTC) has no specific clinical symptoms. Due to the absence of specific symptoms, the disease is usually diagnosed at the stage of metastatic lesions of regional lymph nodes, and sometimes, internal organs. The five- and ten-year survival after detection of distant metastases is 25% and 10%, respectively.OBJECTIVE: To analyze the available foreign and domestic literature to determine the role of PET/CT with various radiopharmaceuticals in the complex radiological diagnos
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44

Nausch, Monika, Lennart Thomas Bach, Jan Czerny, et al. "Effects of CO<sub>2</sub> perturbation on phosphorus pool sizes and uptake in a mesocosm experiment during a low productive summer season in the northern Baltic Sea." Biogeosciences 13, no. 10 (2016): 3035–50. http://dx.doi.org/10.5194/bg-13-3035-2016.

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Abstract. Studies investigating the effect of increasing CO2 levels on the phosphorus cycle in natural waters are lacking although phosphorus often controls phytoplankton development in many aquatic systems. The aim of our study was to analyse effects of elevated CO2 levels on phosphorus pool sizes and uptake. The phosphorus dynamic was followed in a CO2-manipulation mesocosm experiment in the Storfjärden (western Gulf of Finland, Baltic Sea) in summer 2012 and was also studied in the surrounding fjord water. In all mesocosms as well as in surface waters of Storfjärden, dissolved organic phosp
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Mulyati, Sri, Syawaliah Muchtar, Nasrul Arahman, et al. "One-Pot Polymerization of Dopamine as an Additive to Enhance Permeability and Antifouling Properties of Polyethersulfone Membrane." Polymers 12, no. 8 (2020): 1807. http://dx.doi.org/10.3390/polym12081807.

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This paper reports the fabrication of polyethersulfone membranes via in situ hydrogen peroxide-assisted polymerization of dopamine. The dopamine and hydrogen peroxide were introduced into the dope solution where the polymerization occurred, resulting in a single-step additive formation during membrane fabrication. The effectivity of modification was evaluated through characterizations of the resulting membranes in terms of chemical functional groups, surface morphology, porosity, contact angle, mechanical strength and filtration of humic acid solution. The results confirm that the polydopamine
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46

Mohtaram, Fatemeh, Michael Petersen, Maria Ahrenst-Mortensen, et al. "Near-Field Direct Write Electrospinning of PET-Carbon Quantum Dot Solutions." Materials 17, no. 24 (2024): 6242. https://doi.org/10.3390/ma17246242.

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Electrospinning of polymer material has gained a lot of interest in the past decades. Various methods of electrospinning have been applied for different applications, from needle electrospinning to needleless electrospinning. A relatively new variation of electrospinning, namely near-field electrospinning, has been used to generate well-defined patterns. This variation of electrospinning, also known as near-field direct-write electrospinning, allows for precise control of the fiber deposition, sacrificing on the thickness of the resulting fibers. Typically, for this method, melt electrospinnin
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47

Aperia, A., A. Bertorello, and I. Seri. "Dopamine causes inhibition of Na+-K+-ATPase activity in rat proximal convoluted tubule segments." American Journal of Physiology-Renal Physiology 252, no. 1 (1987): F39—F45. http://dx.doi.org/10.1152/ajprenal.1987.252.1.f39.

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We studied the effect of dopamine (DA) on Na+-K+-ATPase activity in proximal convoluted tubule (PCT) segments dissected from perfused rat kidneys. DA inhibited Na+-K+-ATPase activity in a dose-dependent manner. Inhibition was significant with 10(-7) M DA and maximal with 10(-4) M DA. The inhibition was reversible. Enzyme inhibition occurred in the presence of DA and a DA antagonist, metoclopramide, but not when 10(5) M of the DA1 and DA2 agonists fenoldopam mesylate and LY 171555 were added in the absence of DA. In PCT segments incubated with the DA precursor dopa, Na+-K+-ATPase activity was a
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48

Sonnier, Rodolphe, Belkacem Otazaghine, Christelle Vagner, et al. "Exploring the Contribution of Two Phosphorus-Based Groups to Polymer Flammability via Pyrolysis–Combustion Flow Calorimetry." Materials 12, no. 18 (2019): 2961. http://dx.doi.org/10.3390/ma12182961.

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From a set of around 100 phosphorus-containing polymers tested in pyrolysis–combustion flow calorimetry, the contributions to flammability of two phosphorus-containing pendant groups (called 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) and PO3) were calculated using an advanced method previously proposed and validated. The flammability properties include total heat release (THR) and heat release capacity (HRC) measured in standard conditions, i.e., anaerobic pyrolysis and complete combustion. The calculated contributions are in good agreement with the main modes of action of both
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Schneider, B., A. Kraft, E. Moser, E. U. Nitzsche, and S. Hoegerle. "Imaging of a Metastatic Gastrointestinal Carcinoid by F-18-DOPA Positron Emission Tomography." Nuklearmedizin 38, no. 04 (1999): 127–30. http://dx.doi.org/10.1055/s-0038-1632205.

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SummaryThe localization of carcinoids in the gastrointestinal tract is frequently difficult if not impossible with the imaging procedures used to date. It is reported on a patient with metastasizing carcinoid in whom various imaging procedures were not successful in detecting the primary tumor. Due to the importance of primary tumor proof for potential curative surgical therapy, a whole-body positron emission tomography with F-18-DOPA was performed. PET enabled localization of a potential primary tumor in the ileum. Moreover, in addition to the known abdominal lymph node and liver metastases,
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Pretze, M., C. Wängler, and B. Wängler. "6-[18F]Fluoro-L-DOPA: A Well-Established Neurotracer with Expanding Application Spectrum and Strongly Improved Radiosyntheses." BioMed Research International 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/674063.

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For many years, the main application of [18F]F-DOPA has been the PET imaging of neuropsychiatric diseases, movement disorders, and brain malignancies. Recent findings however point to very favorable results of this tracer for the imaging of other malignant diseases such as neuroendocrine tumors, pheochromocytoma, and pancreatic adenocarcinoma expanding its application spectrum. With the application of this tracer in neuroendocrine tumor imaging, improved radiosyntheses have been developed. Among these, the no-carrier-added nucleophilic introduction of fluorine-18, especially, has gained increa
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