Academic literature on the topic 'Potassium conductance'

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Journal articles on the topic "Potassium conductance"

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Butt, A. G., W. L. Clapp, and R. A. Frizzell. "Potassium conductances in tracheal epithelium activated by secretion and cell swelling." American Journal of Physiology-Cell Physiology 258, no. 4 (1990): C630—C638. http://dx.doi.org/10.1152/ajpcell.1990.258.4.c630.

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Increased basolateral membrane K conductance accompanies stimulation of Cl secretion across canine trachea. To assess the K conductance properties, we permeabilized the apical membranes with amphotericin B and monitored the current and conductance caused by K flow across the basolateral membranes. Under basal unstimulated conditions, two K conductances could be distinguished by blockers. One was inhibited only by barium; the other was sensitive also to quinidine and lidocaine. The permeabilities of the basal conductance pathways to K and Rb were similar (PK/PRb approximately equal to 1.5). The
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Frolov, Roman, Esa-Ville Immonen, and Matti Weckström. "Visual ecology and potassium conductances of insect photoreceptors." Journal of Neurophysiology 115, no. 4 (2016): 2147–57. http://dx.doi.org/10.1152/jn.00795.2015.

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Voltage-activated potassium channels (Kv channels) in the microvillar photoreceptors of arthropods are responsible for repolarization and regulation of photoreceptor signaling bandwidth. On the basis of analyzing Kv channels in dipteran flies, it was suggested that diurnal, rapidly flying insects predominantly express sustained K+ conductances, whereas crepuscular and nocturnally active animals exhibit strongly inactivating Kv conductances. The latter was suggested to function for minimizing cellular energy consumption. In this study we further explore the evolutionary adaptations of the photo
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Sivaramakrishnan, S., G. D. Bittner, and M. S. Brodwick. "Calcium-activated potassium conductance in presynaptic terminals at the crayfish neuromuscular junction." Journal of General Physiology 98, no. 6 (1991): 1161–79. http://dx.doi.org/10.1085/jgp.98.6.1161.

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Membrane potential changes that typically evoke transmitter release were studied by recording intracellularly from the excitor axon near presynaptic terminals of the crayfish opener neuromuscular junction. Depolarization of the presynaptic terminal with intracellular current pulses activated a conductance that caused a decrease in depolarization during the constant current pulse. This conductance was identified as a calcium-activated potassium conductance, gK(Ca), by its disappearance in a zero-calcium/EGTA medium and its block by cadmium, barium, tetraethylammonium ions, and charybdotoxin. In
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Krieger, C., and T. A. Sears. "The development of voltege-dependent ionic conductances In murine spinal cord neurones in culture." Canadian Journal of Physiology and Pharmacology 66, no. 10 (1988): 1328–36. http://dx.doi.org/10.1139/y88-217.

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The development of voltage-dependent ionic conductances of foetal mouse spinal cord neurones was examined using the whole-cell patch-clamp technique on neurones cultured from embryos aged 10–12 days (E10–E12) which were studied between the first day in vitro (V1) to V10. A delayed rectifier potassium conductance (IK) and a leak conductance were observed in neurones of E10.V1, E11, V1, and E12, V1 as well as in neurones cultured for longer periods. A rapidly activating and inactivating potassium conductance (IA) was seen in neurones from E11, V2 and E12, V1 and at longer times in vitro. A tetro
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Quadroni, R., and T. Knopfel. "Compartmental models of type A and type B guinea pig medial vestibular neurons." Journal of Neurophysiology 72, no. 4 (1994): 1911–24. http://dx.doi.org/10.1152/jn.1994.72.4.1911.

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1. We have developed compartmental models of guinea-pig medial vestibular nuclei neurons (MVNns). The structure and the parameters of the model cells were chosen to reproduce the responses of type A and type B MVNns as described in electrophysiological recordings. 2. Dynamics of membrane potentials were modeled in 46 and 61 branched electrical compartments for Type A and Type B MVNns, respectively. Each compartment was allowed to contain up to nine active ionic conductances: a fast inactivating sodium conductance, gNa, a persistent sodium conductance, gNap, a low-voltage activated calcium cond
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Kawahara, K., M. Hunter, and G. Giebisch. "Potassium channels in Necturus proximal tubule." American Journal of Physiology-Renal Physiology 253, no. 3 (1987): F488—F494. http://dx.doi.org/10.1152/ajprenal.1987.253.3.f488.

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Potassium channels from the apical and basolateral membranes of Necturus proximal tubule were studied using the patch-clamp technique. The conductance of the basolateral channel was dependent on the pipette K+ concentration (apparent Km, 65.5 mM K+; maximum channel conductance, 49.8 pS). The permeability ratio (PK+/PNa+) was approximately 10:1. The fractional open time increased with hyperpolarization, whereas mean open times did not change. Ba2+ (0.1 mM pipette concentration) blocked the channel and reduced the mean open time. The apical K+ channel was activated with depolarization and had a
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Dinan, Timothy G. "Calcium-Activated Potassium Conductance." British Journal of Psychiatry 151, no. 4 (1987): 455–59. http://dx.doi.org/10.1192/bjp.151.4.455.

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Neuroleptics are structurally a heterogenous group of compounds which possess antipsychotic activity. They increase dopamine metabolites by blocking dopamine receptors and enhancing presynaptic turnover. This forms the cornerstone of the dopamine hypothesis of neuroleptic action, which is supported by wide-ranging behavioural, physiological and biochemical studies. It is, however, clear that neuroleptics are far less specific for the dopamine receptor than was previously considered. They influence a range of neuronal activities, including calcium-activated potassium conductance, which governs
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Desaphy, Jean-François, and Michel Joffre. "Effect of cyclic AMP on the calcium-dependent potassium conductances of rat Leydig cells." Canadian Journal of Physiology and Pharmacology 76, no. 6 (1998): 649–56. http://dx.doi.org/10.1139/y98-066.

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Two potassium conductances have been isolated in rat Leydig cells by their sensitivity to cytosolic calcium and to K+ channel blockers. We used the whole-cell configuration of the patch-clamp technique to investigate their sensitivity to cyclic AMP, the main messenger of luteinizing hormone, which stimulates Leydig cell steroidogenesis. The voltage-dependent potassium conductance is not modified by exposing the cell to 1 mM chlorophenylthio-cyclic AMP (CPT-cAMP), a membrane-permeant analogue of cAMP. By contrast, the large, calcium-activated potassium conductance is upregulated by CPT-cAMP. Fu
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Henderson, R. M., J. Graf, and J. L. Boyer. "Inward-rectifying potassium channels in rat hepatocytes." American Journal of Physiology-Gastrointestinal and Liver Physiology 256, no. 6 (1989): G1028—G1035. http://dx.doi.org/10.1152/ajpgi.1989.256.6.g1028.

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The patch-clamp technique has been used to investigate single-channel and whole cell conductances in freshly isolated rat hepatocytes. Whole cell experiments, with high (144 mM) intracellular and extracellular potassium as the principal conductive species, show some variation between cells in the current-voltage relationship (mean whole-cell conductance at physiological potentials being 2.7 nS). This may suggest functional heterogeneity of cells. The most common finding is that the current-voltage relationship shows inward rectification. This is reflected in cell-attached single-channel record
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Kyriacou, E. "Reconstitution of Single Potassium Channels from Bovine Gallbladder Epithelium." Journal of International Medical Research 26, no. 4 (1998): 188–99. http://dx.doi.org/10.1177/030006059802600403.

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The study of molecular transport across gall-bladder epithelium may contribute to our understanding of the pathophysiology of gall-bladder disease. The aim of this study was to reconstitute and characterize single potassium ion channels in bovine gall-bladder epithelial mucosa – both apical and basolateral aspects. Standard subcellular fractionation techniques were used to form either apical or basolateral closed-membrane vesicles from the mucosal epithelium of fresh gall bladders from healthy young adult cattle. Vesicular ion channels were incorporated into voltage-clamped planar lipid bilaye
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Dissertations / Theses on the topic "Potassium conductance"

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D'hoedt, Dieter. "Structure-function analyses of small-conductance, calcium-activated potassium channels." Diss., [S.l.] : [s.n.], 2005. http://edoc.ub.uni-muenchen.de/archive/00006036.

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Lippiat, Jonathan David. "Molecular properties of recombinant large conductance calcium-activated potassium channels." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/29928.

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1. Currents through large conductance calcium-activated potassium channels were recorded using path clamp from human embryonic kidney (HEK) cells expressing recombinant DNA. 2. The permeation of potassium ions through single cloned rat channels, rSlo+1m was described using Eyring's rate theory. The model included two energy wells and three barriers. N-methyl-D-glucamine was found to block potassium permeation by binding to the intracellular binding site in the pore. 3. A HEK cell line was generated that stably expressed the human bladder BKCa channel subunit (hSlo). Macroscopic currents record
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Bi, Danlei. "Palmitoylation of large conductance voltage- and calcium-dependent potassium (BK) channels." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17286.

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S-palmitoylation is a reversible post-translational lipid modification of proteins by adding a 16-carbon palmitate onto a cysteine residue. Palmitoylation has been shown to control the trafficking and function of many signalling proteins including ion channels. In this Thesis, palmitoylation is shown to control both the plasma membrane expression and gating properties of large conductance calcium- and voltage- dependent potassium (BK) channels. The BK channel is assembled from four pore-forming α-subunits. Each α-subunit contains seven transmembrane domains (S0-S6), with an extracellular N-ter
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Deng, Zhihui. "SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (SK) CHANNELS IN MAMMALIAN SPINAL MOTONEURONS." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1237821684.

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Millar, Julie Anne. "Characterisation of a novel potassium conductance in rat cerebellar granule neurons." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392110.

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McCartney, Claire Elizabeth. "Effect of hypoxia on neuronal large conductance calcium-activated potassium (BKca) channels." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410156.

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Macdonald, Stephen Hsiao-Feng. "Alternative splicing of large-conductance calcium- and voltage-activated potassium (BK) channels." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29237.

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The aim of this thesis was to test the hypotheses that: i) alternative splicing may control subcellular localisation of BK channel α-subunits and ii) splice variants are differentially expressed in tissues, using the murine BK channel as the model system. To address whether alternative splice variants may be trafficked specifically to different subcellular compartments, epitope-tagged BK channel splice variants were expressed in a mammalian epithelial and endocrine cells. STREX and ZERO variants, in contrast to splice variant Δe23 that is C-terminally truncated, efficiently trafficked to the p
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Alsaleh, Dana. "Bifurcations in a model of Per1 neurons." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/bifurcations-in-a-model-of-per1-neurons(0d004fab-c795-4afe-8dc7-6a807e946e2b).html.

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Circadian rhythms refer to the physiological and biological processes that fluctuate over a 24-hour period. These rhythms are found in most living things such as animals, plants and fungi. In mammals, circadian rhythms are mainly generated and regulated by the suprachiasmatic nucleus (SCN).The period (Per1) gene in the SCN plays a key role in directing circadian rhythms. Per1 expression increases during the day and decreases at night. The neurons which express the Per1 gene show different behaviours to non-Per1 neurons during the day-night cycle. Per1 neurons are in a state of repetitive firin
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Power, Eoin Christopher. "Synthesis of ligands for the large conductance calcium activated potassium channel (BK←c←a)." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395680.

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Bahia, Parmvir Kaur. "A study of small and intermediate conductance calcium-activated potassium channels in sensory neurones." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445301/.

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The role of small and intermediate conductance calcium-activated potassium channels (SK and IK channels) in dorsal root ganglion (DRG) neurones was examined. Sixteen antibodies raised against human or rat SK/IK channel peptide epitopes were tested for their ability to stain cells expressing channel protein. Of sixteen antibodies, 12 (6 to SKI, 1 to SK2, 2 to SK3 and 3 to IK) were deemed suitable for immunohistochemistry in human or rat tissue. Real-time quantitative PCR (qPCR) of rat DRG cDNA was performed to examine SK/IK expression levels. DRG neurones produce mRNA for all SK/IK channels and
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Books on the topic "Potassium conductance"

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Dickstein, Jodi Beth. Calcium dependent potassium conductance in the inhibitory axonal terminal of the crayfish. National Library of Canada, 1993.

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Book chapters on the topic "Potassium conductance"

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Madison, Daniel V., and Roger A. Nicoll. "Increases in Potassium Conductance." In Neurotransmitters and Cortical Function. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-0925-3_37.

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Holze, Rudolf. "Ionic conductance of potassium formate." In Electrochemistry. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-49251-2_917.

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Holze, Rudolf. "Ionic conductance of potassium acetate." In Electrochemistry. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-49251-2_920.

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Holze, Rudolf. "Ionic conductance of potassium dichloroacetate." In Electrochemistry. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-49251-2_921.

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Holze, Rudolf. "Ionic conductance of potassium trichloroacetate." In Electrochemistry. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-49251-2_922.

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Holze, Rudolf. "Ionic conductance of potassium butyrate." In Electrochemistry. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-49251-2_923.

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Holze, Rudolf. "Ionic conductance of potassium picrate." In Electrochemistry. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-49251-2_924.

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Holze, Rudolf. "Ionic conductance of potassium benzoate." In Electrochemistry. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-49251-2_925.

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Holze, Rudolf. "Ionic conductance of potassium nitrotoluenesulphonate." In Electrochemistry. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-49251-2_927.

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Holze, Rudolf. "Ionic conductance of potassium phthalate." In Electrochemistry. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-49251-2_928.

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Conference papers on the topic "Potassium conductance"

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Pe�aranda, Angelina, Blas Echebarria, Enrique Alvarez-Lacalle, and Inmaculada R. Cantalapiedra. "Effects of Small Conductance Calcium Activated Potassium Channels in Cardiac Myocytes." In 2017 Computing in Cardiology Conference. Computing in Cardiology, 2017. http://dx.doi.org/10.22489/cinc.2017.308-050.

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Yam, Yeung, and Chi-Cheung Lo. "A Mathematical Model For Potassium Channel Conductance in Hodgkin-Huxley Experiments." In 2007 American Control Conference. IEEE, 2007. http://dx.doi.org/10.1109/acc.2007.4283106.

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Fabbri, Alan, Michelangelo Paci, Jari Hyttinen, Ronald Wilders, and Stefano Severi. "Effects of the Small Conductance Calcium-Activated Potassium Current (IsK) in Human Sinoatrial Node." In 2017 Computing in Cardiology Conference. Computing in Cardiology, 2017. http://dx.doi.org/10.22489/cinc.2017.121-219.

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Scruggs, A., G. Grabauskas, and S. K. Huang. "The Large Conductance Potassium (BK) Channel Promotes Myofibroblast Differentiation Through Increases In Calcium Signaling." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2280.

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Scruggs, A., G. Grabauskas, and S. K. Huang. "The Large Conductance Potassium (BK) Channel Promotes Myofibroblast Differentiation Through Increases in Calcium Signaling." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4418.

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Vang, Alexander, Anlong Li, and Gaurav Choudhary. "Effect Of Large Conductance Calcium-Activated Potassium (BK) Channel Opener, NS1619, On Normoxic And Hypoxic Pulmonary Vasculature." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4833.

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Scruggs, A., D. Beard, J. Anumonwo, and S. K. Huang. "The Large Conductance Potassium (BK) Channel Increases Calcium Signaling, Fibroblast Proliferation and Mitochondrial Dysfunction in Normal and IPF Fibroblasts." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5325.

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