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Dissertations / Theses on the topic 'Potassium conductance'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

D'hoedt, Dieter. "Structure-function analyses of small-conductance, calcium-activated potassium channels." Diss., [S.l.] : [s.n.], 2005. http://edoc.ub.uni-muenchen.de/archive/00006036.

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2

Lippiat, Jonathan David. "Molecular properties of recombinant large conductance calcium-activated potassium channels." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/29928.

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1. Currents through large conductance calcium-activated potassium channels were recorded using path clamp from human embryonic kidney (HEK) cells expressing recombinant DNA. 2. The permeation of potassium ions through single cloned rat channels, rSlo+1m was described using Eyring's rate theory. The model included two energy wells and three barriers. N-methyl-D-glucamine was found to block potassium permeation by binding to the intracellular binding site in the pore. 3. A HEK cell line was generated that stably expressed the human bladder BKCa channel subunit (hSlo). Macroscopic currents record

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3

Bi, Danlei. "Palmitoylation of large conductance voltage- and calcium-dependent potassium (BK) channels." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17286.

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S-palmitoylation is a reversible post-translational lipid modification of proteins by adding a 16-carbon palmitate onto a cysteine residue. Palmitoylation has been shown to control the trafficking and function of many signalling proteins including ion channels. In this Thesis, palmitoylation is shown to control both the plasma membrane expression and gating properties of large conductance calcium- and voltage- dependent potassium (BK) channels. The BK channel is assembled from four pore-forming α-subunits. Each α-subunit contains seven transmembrane domains (S0-S6), with an extracellular N-ter

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4

Deng, Zhihui. "SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (SK) CHANNELS IN MAMMALIAN SPINAL MOTONEURONS." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1237821684.

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5

Millar, Julie Anne. "Characterisation of a novel potassium conductance in rat cerebellar granule neurons." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392110.

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6

McCartney, Claire Elizabeth. "Effect of hypoxia on neuronal large conductance calcium-activated potassium (BKca) channels." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410156.

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7

Macdonald, Stephen Hsiao-Feng. "Alternative splicing of large-conductance calcium- and voltage-activated potassium (BK) channels." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29237.

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The aim of this thesis was to test the hypotheses that: i) alternative splicing may control subcellular localisation of BK channel α-subunits and ii) splice variants are differentially expressed in tissues, using the murine BK channel as the model system. To address whether alternative splice variants may be trafficked specifically to different subcellular compartments, epitope-tagged BK channel splice variants were expressed in a mammalian epithelial and endocrine cells. STREX and ZERO variants, in contrast to splice variant Δe23 that is C-terminally truncated, efficiently trafficked to the p

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8

Alsaleh, Dana. "Bifurcations in a model of Per1 neurons." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/bifurcations-in-a-model-of-per1-neurons(0d004fab-c795-4afe-8dc7-6a807e946e2b).html.

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Circadian rhythms refer to the physiological and biological processes that fluctuate over a 24-hour period. These rhythms are found in most living things such as animals, plants and fungi. In mammals, circadian rhythms are mainly generated and regulated by the suprachiasmatic nucleus (SCN).The period (Per1) gene in the SCN plays a key role in directing circadian rhythms. Per1 expression increases during the day and decreases at night. The neurons which express the Per1 gene show different behaviours to non-Per1 neurons during the day-night cycle. Per1 neurons are in a state of repetitive firin

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9

Power, Eoin Christopher. "Synthesis of ligands for the large conductance calcium activated potassium channel (BKâ†câ†a)." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395680.

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10

Bahia, Parmvir Kaur. "A study of small and intermediate conductance calcium-activated potassium channels in sensory neurones." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445301/.

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The role of small and intermediate conductance calcium-activated potassium channels (SK and IK channels) in dorsal root ganglion (DRG) neurones was examined. Sixteen antibodies raised against human or rat SK/IK channel peptide epitopes were tested for their ability to stain cells expressing channel protein. Of sixteen antibodies, 12 (6 to SKI, 1 to SK2, 2 to SK3 and 3 to IK) were deemed suitable for immunohistochemistry in human or rat tissue. Real-time quantitative PCR (qPCR) of rat DRG cDNA was performed to examine SK/IK expression levels. DRG neurones produce mRNA for all SK/IK channels and

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11

Ma, Dongyu [Verfasser], and Rudolf [Akademischer Betreuer] Schubert. "Interaction of voltage-gated potassium channels and large-conductance calcium-sensitive potassium channels in vascular smooth muscle / Dongyu Ma ; Betreuer: Rudolf Schubert." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177691663/34.

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12

Petrik, David. "The role of the ß4 subunit in phosphorylation of calcium-activated potassum [sic] channels a dissertation /." San Antonio : UTHSC, 2008. http://proquest.umi.com.libproxy.uthscsa.edu/pqdweb?did=1588771871&sid=3&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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13

Loane, David James. "A protein-protein interaction study of the large conductance calcium-activated potassium channel in rat brain." Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409416.

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14

Sane, Mukta. "Role of Large Conductance, Calcium-Activated Potassium Channels (BKCa) in Vasorelaxation of Nitrate Tolerant Mesenteric Arteries." Diss., North Dakota State University, 2016. http://hdl.handle.net/10365/25665.

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15

Saqar, Wedad Ali. "Characterization of Small Conductance Calcium-Activated Potassium Channels in a Human Lens Epithelium Cell Line (B3)." Wright State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1401279427.

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16

Murphy, Matthew M. "Investigating the Effects of CyPPA on Small-Conductance Calcium-Activated Potassium Channels in SOD1G93A Transgenic Mouse Model." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1589929963490428.

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17

Coghill, Lorraine Sheila. "Regulation of large conductance calcium- and voltage-activated potassium (BK) channel splice variants by protein kinase A." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/23309.

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18

Tjong, Yung-wui. "Mechanisms of attenuated large conductance calcium-activated potassium channel activity in rat hippocampal CA1 pyramidal neurons in chronic intermittent hypoxia." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39793953.

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19

Kye, Min-Jeong. "Regulation of small-conductance, calcium-activated potassium channels (SK) in mouse brain in response to aging and stress." [S.l.] : [s.n.], 2004. http://webdoc.sub.gwdg.de/diss/2004/kye/kye.pdf.

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20

Chu, Benson. "Alcohol Modulation of N-methyl-D-aspartate Gated Receptor/Channels and Large Conductance Calcium-Activated Potassium Channels: a Dissertation." eScholarship@UMMS, 1998. http://escholarship.umassmed.edu/gsbs_diss/164.

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Clinically relevant concentrations of ethanol modulate the function of a number of ion channel proteins. A fundamental question regarding the effects of alcohol is whether the drug modifies ion channels by directly binding to the protein, indirectly by perturbing the surrounding membrane lipid, or some combination of both. This thesis further characterized ethanol's site of action by examining the effects of ethanol on N-methyl-D-aspartate (NMDA) receptor/channels and large conductance Ca2+-activated K+ (BK) channels at a number of levels using direct electrophysiological methods. In Chapter O

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21

Tischendorf, Michael [Verfasser]. "Der Einfluss des Small Conductance Potassium Channel 4 (SK4) auf die kardiale Differenzierung embryonaler und induzierter pluripotenter Stammzellen / Michael Tischendorf." Ulm : Universität Ulm, 2019. http://d-nb.info/1179226178/34.

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22

Brecht, Ellliott James. "Neuropeptide Modulation of the Large Conductance Potassium (BK) Channel in the Auditory System: Therapeutic Implications for Age-Related Hearing Loss." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6641.

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The auditory temporal processing deficits associated with age-dependent hearing decline have been increasingly attributed to issues beyond peripheral hearing loss. Age-related hearing loss (ARHL), also known as presbycusis, is linked with changes in the expression of both excitatory and inhibitory neurotransmitters in the central auditory system. There are also age-related changes in the expression and function of the ion channels which mediate action potential firing. The slow, Ca2+ activated, K+ channels of the BK-type are essential in controlling both neurotransmitter release and neural com

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23

Shah, Yousef. "Effects of point mutations on the block of SK3 small-conductance calcium-activated potassium channels expressed in mammalian cell lines." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1446491/.

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Small conductance calcium-activated K+ channels (SK channels) form a subfamily of K+ -selective, volt age-insensitive channels that have been recently cloned. This thesis is concerned primarily with an investigation of the pharmacology of these channels. Understanding their pharmacology is of potential clinical importance since SK channels participate in diverse physiological roles, for example, generating neuronal afterhyperpolarizations (that set tonic firing frequencies) and regulating smooth muscle contraction. This thesis consists of two parts. The first is concerned with expressing and e

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24

Hillman, David James. "Membrane currents evoked by vasoactive compounds in vascular endothelial cells : contributions of small and intermediate conductance calcium-activated potassium channels." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445578/.

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The contribution of different calcium-activated potassium channel subtypes to agonist-evoked whole-cell currents was studied in cultured pig coronary artery endothelial cells. From a resting membrane potential of-5.9 0.5mV (n=102), 1-lOuM ATP, 1-1 OnM substance P and 1-lOOnM bradykinin hyperpolarised cell rafts to -50.7 1.6mV (n=76), -45.7 4.7mV (n=19) and -59.1 3.5mV (n=16), respectively. In small clusters of cells, 1 OuM ATP evoked outward currents which reversed close to EK and were sensitive to both the SKca channel blocker UCL 1848 (IC5o 1.2nM -65% maximal block) and the IKca/BKca channel

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25

Braxton, Joi Requan. "Effect of preload on the response of mouse trachea smooth muscle to cholinergic stimulation a thesis /." San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=33&CISOBOX=1&REC=10.

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26

Tharp, Darla L. "Role of the intermediate-conductance Ca²⁺-activated K⁺ channel (K[ca]3.1) in coronary smooth muscle cell phenotypic modulation." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5936.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "December 2007" Includes bibliographical references.

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27

Thevenod, Frank. "Regulation of pancreatic and parotid zymogen granule chloride and potassium ion conductance pathways by cytosol nucleotides: Phosphorylation-dependent and -independent mechanisms." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1056737719.

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28

Holland, Michael. "A patch clamp study of pharmacological and physiological regulators of large conductance calcium-activated potassium channels in arterial smooth muscle cells." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/29937.

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In the 1980s a group of vasodilator drugs were found to possess a common mechanism which involved opening KATP channels located in the cell membrane of smooth muscle cells, leading to vasorelaxation via membrane hyperpolarisation. A number of additional K+ channels have been identified in vascular smooth muscle cells and one of these channels, the large conductance calcium-activated K+ channel (BKCa), is a promising therapeutic target.;This thesis uses the various configurations of the patch-clamp technique to examine the effects of NS1619, nitric oxide (NO) and compounds resulting from the ac

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29

Apolinar, Sanrda. "BK channel involvement in beta-adrenergic relaxation of murine tracheal smooth muscle a thesis /." San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=32&CISOBOX=1&REC=3.

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30

Chanrachakul, Boonsri. "Characterisation and interaction between Î²â‚‚ adrenoceptor (AR) and the large conductance calcium-activated potassium (BK_C_a) channel in human myometrium during pregnancy." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429071.

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31

Köpfer, David Alexander [Verfasser], Bert de [Akademischer Betreuer] Groot, and Ralf [Akademischer Betreuer] Ficner. "Ion Conductance Through Potassium Channels : Studied by Molecular Dynamics Simulations / David Alexander Köpfer. Gutachter: Bert de Groot ; Ralf Ficner. Betreuer: Bert de Groot." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/107709678X/34.

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32

Raza, Muhammad Liaquat [Verfasser]. "Effects of small conductance calcium activated potassium channel agonists on seizure like events in in vitro slices and slice cultures / Muhammad Liaquat Raza." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1140487043/34.

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33

Benhassine, Narimane. "Biophysical properties, distribution and functional importance of large-conductance Calcium-dependent Potassium channels in layer 5 pyramidal neurons of the rat somatosensory cortex /." [S.l.] : [s.n.], 2005. http://www.zb.unibe.ch/download/eldiss/05benhassine_n.pdf.

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34

Krishnamoorthy, Gayathri. "MECHANISM OF CALCIUM DEPENDENT GATING OF BKCa CHANNELS: RELATING PROTEIN STRUCTURE TO FUNCTION." online version, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1144444855.

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35

Martineau, Elsa. "Rôle joué par le potassium dans la réponse au déficit hydrique du maïs (Zea mays L.) : des mécanismes physiologiques au fonctionnement intégré du peuplement." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0286/document.

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Le potassium (K) est un élément majeur connu pour contribuer à la résistance des plantes à la sècheresse. L'étudede son influence sur la réponse physiologique du maïs (Zea mays L.) sous contrainte hydrique est essentiellepour prédire la future productivité dans un contexte de changements climatiques, en particulier de la diminutiondes précipitations. Des modalités d'apports en K et en eau ont été croisées et soumises à des plants de maïs,élevés en condition contrôlées ou cultivés au champ. La croissance (biomasses aériennes et racinaires,rendements en grain) ainsi que les mécanismes écophysiol

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36

Mpari, Bedel Raymond. "Implication des canaux potassium dépendant du calcium et de faible conductance au cours des processus mnésiques chez le rat : approche comportementale, pharmacologique, biochimique et biomoléculaire." Aix-Marseille 1, 2007. http://theses.univ-amu.fr.lama.univ-amu.fr/2007AIX11006.pdf.

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Cette étude a pour objectif d’évaluer l’implication des canaux SK (SK1, SK2 et SK3) dans les processus d’apprentissage et de mémorisation. Dans un premier temps, nous avons comparé les effets de l’apamine, une toxine inactivant les canaux SK composés des sous-unités SK2 et SK3 à ceux de la Lei-Dab7, spécifique, à haute affinité uniquement, de la sous-unité SK2, au cours processus mnésiques. Injectées par voie intracérébroventriculaire, l'apamine induit une facilitation mnésique durant la consolidation des informations alors que la Lei-Dab7 n’a aucun effet dans un même contexte de mémorisation.

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37

Ro, Seungil. "SK channels : distribution, function and regulation in mouse colonic myocytes /." abstract and full text PDF (UNR users only), 2002. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3090879.

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38

Hoyles, Matthew, and Matthew Hoyles@anu edu au. "Computer Simulation of Biological Ion Channels." The Australian National University. Theoretical Physics, 2000. http://thesis.anu.edu.au./public/adt-ANU20010702.135814.

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This thesis describes a project in which algorithms are developed for the rapid and accurate solution of Poisson's equation in the presence of a dielectric boundary and multiple point charges. These algorithms are then used to perform Brownian dynamics simulations on realistic models of biological ion channels. An iterative method of solution, in which the dielectric boundary is tiled with variable sized surface charge sectors, provides the flexibility to deal with arbitrarily shaped boundaries, but is too slow to perform Brownian dynamics. An analytical solution is derived, which is faster

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39

Canova, Giovana Calicchio. "Estudo in vitro do efeito de agentes anti-hiperestésicos na permeabilidade dentinária por meio de testes de condutividade hidráulica e de espectroscopia de impedância eletroquímica." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/25/25138/tde-09112007-100638/.

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O objetivo do presente estudo foi quantificar, in vitro, a permeabilidade da dentina tratada com dois agentes anti-hiperestésicos à base de oxalato e um à base de fosfato de cálcio, por meio de testes de condutividade hidráulica e de espectroscopia de impedância eletroquímica e, ainda, determinar se espectroscopia de impedância eletroquímica pode ser considerada um método alternativo para avaliar a capacidade obstrutiva de agentes antihiperestésicos. Para o teste de condutividade hidráulica foram utilizados vinte quatro discos de dentina, obtidos de terceiros molares humanos extraídos, que for

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40

Spruce, Austen Edwin. "Potassium conductances of skeletal muscle investigated using single channel recording." Thesis, University of Leicester, 1986. http://hdl.handle.net/2381/33614.

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This thesis describes studies of unitary currents flowing through two different potassium (K) channels present in sarcolemmal vesicles of the frog, Rana temporaria. The ATP-regulated K-channel is described first and the results are divided into three parts. Firstly, ATP applied to the cytoplasmic face of a membrane patch closes the channels in a dose-dependent fashion. Different nucleotides and other metabolic substances are used in order to find chemicals which can substitute for ATP or which regulate its effect. Secondly, the permeability properties of the channel are described. Ion flux is

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41

MacKenzie, Georgina Louise. "Control of membrane excitability by potassium and chloride leak conductances." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/7038.

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The permeability of the neuronal membrane to different ions determines both resting membrane potential (RMP) and input conductance. These parameters determine the cells response to synaptic input. In this thesis I have examined how the molecular properties of potassium and chloride ion channels can influence neuronal excitability in ways that have not previously been considered. For example, two‐pore domain potassium (K2P) channels open at rest to generate a persistent potassium ion efflux. In addition to its accepted role in setting the RMP, I have tested the hypothesis that this conductance

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42

Crotty, Christopher M. "Two distinct outward K+ conductances are simultaneously activated in TBY-2 suspension culture protoplasts." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38174.

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Two kinetically and pharmacologically distinct outward K+ conductances were found to be simultaneously activated at the plasma membrane of TBY-2 suspension culture protoplasts using the whole-cell patch-clamp technique. We used a modified Hodgkin-Huxley model to quantify the activation kinetics of the outward current. Time constants for the two conductances derived from the model differed in magnitude by 5--10 fold over the voltage range from -10 mV to +50 mV, allowing their classification as either fast or slow. Deactivation kinetics were better fit by two exponential terms rather than one, y

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43

Wynne, Patricia M. "Ethanol Sensitivity and Tolerance of Rat Neuronal BK Channels: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/399.

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BK channels are well studied targets of acute ethanol action. They play a prominent role in neuronal excitability and have been shown to play a significant role in behavioral ethanol tolerance in invertebrates. The focus of my work centers on the effects of alcohol on the BK channel and comprises studies that examine how subcellular location affects acute ethanol sensitivity and how duration of acute alcohol exposure impacts the development of rapid tolerance. My results also provide potential mechanisms which underlie acute sensitivity and rapid tolerance. I first explore BK channel sensitivi

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44

Laclau, Patricia Renee Françoise Battie. "Efeitos da adubação potássica sobre a adaptação à seca do Eucalyptus grandis." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/64/64134/tde-16012014-160920/.

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Com a continuação do aquecimento global, prevê-se o aumento dos períodos de seca, um dos mais importantes fatores abióticos a afetar o crescimento dos eucaliptos no Brasil. Nessa direção, as práticas silviculturais poderiam adaptar-se para favorecer os mecanismos de adaptação das árvores à seca. Assim, na Estação Experimental de Itatinga, foram avaliados os efeitos da adubação potássica sobre os aspectos produtivos e fisiológicos de um povoamento de Eucalyptus grandis, em primeira rotação, submetido à exclusão parcial de chuva durante trinta meses após o plantio. O dispositivo experimental foi

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45

Poulter, Michael Owen. "The role of potassium conductances in regulating the excitability of myelinated axons /." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74560.

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Previous results indicate that the functional properties of myelinated axons are considerably more complex than previously believed. The purpose of this study was to further examine the functional properties of potassium conductances in dorsal and ventral root (DRA; VRA) frog myelinated axons by intracellular microelectrode recording. The voltage responses to hyperpolarizing current injection demonstrated: (1) a nonlinear voltage current (V/I) relationship in the region just below resting membrane potential; (2) a linear peak and steady state V/I relationship below $ approx$ $-$95 mV; (3) a la

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46

Weatherholt, Riley Madison. "Road Salt Runoff into Freshwater Wetlands: Trends in SpecificConductance and Ion Concentration." Kent State University Honors College / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1557152479759316.

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47

Flynn, Elaine Rose Maria. "Ionic conductances involved in the electrical activity of the canine gastrointestinal tract /." abstract and full text PDF (UNR users only), 1999. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:9934138.

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48

Lallet-Daher, Hélène. "Implication du canal potassique calcium dépendant à conductance intermédiaire IKca1 dans la cancerogenèse humaine." Thesis, Lille 1, 2008. http://www.theses.fr/2008LIL10135/document.

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Des études récentes montrent que l'homéostasie calcique intracellulaire, ainsi que l'expression et l'activité de canaux ioniques jouent un rôle essentiel dans le contrôle de la prolifération cellulaire aussi bien dans un contexte physiologique que dans certains cancers. Cependant, aucune approche proposant les canaux ioniques comme cible thérapeutique n'est actuellement envisagée dans le cadre des traitements des cancers de la prostate. Dans ce travail nous avons mis en évidence l'expression, la fonctionnalité et l'implication des canaux potassiques calcium-activés (IKca1) dans la prolifératio

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49

Partiseti, Michel, and Henri Korn. "Regulation de l'expression et fonctions des conductances potassium et calcium des lymphocytes au cours du cycle cellulaire." Paris 6, 1994. http://www.theses.fr/1994PA066420.

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Le cycle cellulaire des lymphocytes est jalonne d'etapes au cours desquelles ceux-ci recoivent de multiples signaux de leur environnement permettant leur maturation et conduisant a des etats d'activation, de proliferation ou encore de differenciation. Afin de caracteriser les flux calciques et potassiques impliques et d'etudier leurs roles respectifs, nous avons utilise des techniques d'imagerie dynamique de fluorescence et du patch-clamp. Nous avons mis en evidence que ces cellules expriment une conductance potassique activee par une augmentation de la concentration intracellulaire de calcium

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Faivre, Jean-François. "Caracterisation et fonction physiologique de la conductance potassique inhibee par l'atp intracellulaire dans les cellules cardiaques." Paris 11, 1990. http://www.theses.fr/1990PA112262.

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Abstract:

Les resultats presentes dans ce memoire concernent la conductance potassique activee lorsque le milieu intracellulaire est deplete en adenosine 5-triphosphate (atp). Les conditions dans lesquelles cette conductance peut presenter un interet physiologique ne sont pas clairement etablies dans la litterature. Dans une premiere partie, nous avons cherche a mettre en evidence cette conductance sur les cellules cardiaques de rat ou de cobaye par la technique du patch-clamp. A l'echelle unitaire, cette conductance fut activee par l'excision du fragment de membrane isole sous la pipette dans la config

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