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1

Reichenbach, Andreas, Andre Henke, Wolfgang Eberhardt, Winfried Reichelt, and Dietrich Dettmer. "K+ ion regulation in retina." Canadian Journal of Physiology and Pharmacology 70, S1 (1992): S239—S247. http://dx.doi.org/10.1139/y92-267.

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During onset and offset of illumination, considerable changes in extracellular K+ concentration ([K+]e) occur within particular retinal layers. There are two ways in which glial cells may control [K+]e: (1) by space-independent processes, for example, by K+ uptake due to the Na+–K+ ATPase, and (2) by space-dependent processes, that is, by spatial buffering currents flowing through K+ channels. Rabbit retinal Müller (glial) cells were studied for expression of mechanisms supporting both kinds of processes. This review demonstrates that rabbit Müller cells have Na–K pumps whose distribution and
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2

ZHONG, YI-SHENG, JING WANG, WANG-MIN LIU, and YI-HUA ZHU. "Potassium ion channels in retinal ganglion cells (Review)." Molecular Medicine Reports 8, no. 2 (2013): 311–19. http://dx.doi.org/10.3892/mmr.2013.1508.

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3

Pramudita, James C., Vanessa K. Peterson, Justin A. Kimpton, and Neeraj Sharma. "Potassium-ion intercalation in graphite within a potassium-ion battery examined usingin situX-ray diffraction." Powder Diffraction 32, S2 (2017): S43—S48. http://dx.doi.org/10.1017/s0885715617000902.

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Graphite has been widely used as a negative electrode material in lithium-ion batteries, and recently it has attracted attention for its use in potassium-ion batteries. In this study, the firstin situX-ray diffraction characterisation of a K/graphite electrochemical cell is performed. Various graphite intercalation compounds are found, including the stage three KC36and stage one KC8compounds,along with the disappearance of the graphite during the potassiation process. These results show new insights on the non-equilibrium states of potassium-ion intercalation into graphite in K/graphite electr
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4

Van Mil, H. G. J. "Analysis of a Model Describing the Dynamics of Intracellular Ion Composition in Biological Cells." International Journal of Bifurcation and Chaos 08, no. 05 (1998): 1043–47. http://dx.doi.org/10.1142/s0218127498000851.

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An electrophysiological model describing the dynamics of the intracellular ion concentration and the membrane potential (Vm) in biological cells is presented. The model links passive ion fluxes through channels of sodium, potassium and chloride to active ion fluxes generated by the sodium potassium pump. To model the interaction of Vm to the ionic fluxes Kirchhoff current law is used. Only one Vm-dependent permeability as represented by an inwardly rectifying potassium channel (IKR) is incorporated. It is shown that the resulting system of ordinary differential equations is degenerate. Decompo
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5

Quraishi, Imran H., and Robert M. Raphael. "Computational model of vectorial potassium transport by cochlear marginal cells and vestibular dark cells." American Journal of Physiology-Cell Physiology 292, no. 1 (2007): C591—C602. http://dx.doi.org/10.1152/ajpcell.00560.2005.

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Cochlear marginal cells and vestibular dark cells transport potassium into the inner ear endolymph, a potassium-rich fluid, the homeostasis of which is essential for hearing and balance. We have formulated an integrated mathematical model of ion transport across these epithelia that incorporates the biophysical properties of the major ion transporters and channels located in the apical and basolateral membranes of the constituent cells. The model is constructed for both open- and short-circuit situations to test the extremes of functional capacity of the epithelium and predicts the steady-stat
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6

Cho, Youngtak, Viet Anh Pham Ba, Jin-Young Jeong, Yoonji Choi, and Seunghun Hong. "Ion-Selective Carbon Nanotube Field-Effect Transistors for Monitoring Drug Effects on Nicotinic Acetylcholine Receptor Activation in Live Cells." Sensors 20, no. 13 (2020): 3680. http://dx.doi.org/10.3390/s20133680.

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We developed ion-selective field-effect transistor (FET) sensors with floating electrodes for the monitoring of the potassium ion release by the stimulation of nicotinic acetylcholine receptors (nAChRs) on PC12 cells. Here, ion-selective valinomycin-polyvinyl chloride (PVC) membranes were coated on the floating electrode-based carbon nanotube (CNT) FETs to build the sensors. The sensors could selectively measure potassium ions with a minimum detection limit of 1 nM. We utilized the sensor for the real-time monitoring of the potassium ion released from a live cell stimulated by nicotine. Notabl
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7

Hedrich, Rainer. "Ion Channels in Plants." Physiological Reviews 92, no. 4 (2012): 1777–811. http://dx.doi.org/10.1152/physrev.00038.2011.

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Since the first recordings of single potassium channel activities in the plasma membrane of guard cells more than 25 years ago, patch-clamp studies discovered a variety of ion channels in all cell types and plant species under inspection. Their properties differed in a cell type- and cell membrane-dependent manner. Guard cells, for which the existence of plant potassium channels was initially documented, advanced to a versatile model system for studying plant ion channel structure, function, and physiology. Interestingly, one of the first identified potassium-channel genes encoding the Shaker-
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8

CORREIA, MANNING J., KATHERINE J. RENNIE, and PAUL KOO. "Return of Potassium Ion Channels in Regenerated Hair Cells." Annals of the New York Academy of Sciences 942, no. 1 (2006): 228–40. http://dx.doi.org/10.1111/j.1749-6632.2001.tb03749.x.

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9

Berkowitz, L. R., and E. P. Orringer. "Passive sodium and potassium movements in sickle erythrocytes." American Journal of Physiology-Cell Physiology 249, no. 3 (1985): C208—C214. http://dx.doi.org/10.1152/ajpcell.1985.249.3.c208.

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Deoxygenation causes an increase in passive Na and K movements across the membrane of the sickle erythrocyte. Some investigators find that these ion movements are accompanied by cell dehydration, while others find no evidence for cell water loss with sickling. Because gelation of hemoglobin S would be enhanced by cell water loss, we reinvestigated Na and K movements in sickle cells to define further the role that ion movements might play in the pathogenesis of sickling. With deoxygenation, we found that sickle cells gained Na and lost K without losing cell water. These net ion movements were n
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10

Younes, Samar, Nisreen Mourad, Mohamed Salla, Mohamad Rahal, and Dalal Hammoudi Halat. "Potassium Ion Channels in Glioma: From Basic Knowledge into Therapeutic Applications." Membranes 13, no. 4 (2023): 434. http://dx.doi.org/10.3390/membranes13040434.

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Ion channels, specifically those controlling the flux of potassium across cell membranes, have recently been shown to exhibit an important role in the pathophysiology of glioma, the most common primary central nervous system tumor with a poor prognosis. Potassium channels are grouped into four subfamilies differing by their domain structure, gating mechanisms, and functions. Pertinent literature indicates the vital functions of potassium channels in many aspects of glioma carcinogenesis, including proliferation, migration, and apoptosis. The dysfunction of potassium channels can result in pro-
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11

Schwab, Albrecht, Peter Hanley, Anke Fabian, and Christian Stock. "Potassium Channels Keep Mobile Cells on the Go." Physiology 23, no. 4 (2008): 212–20. http://dx.doi.org/10.1152/physiol.00003.2008.

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Cell motility is a prerequisite for the creation of new life, and it is required for maintaining the integrity of an organism. Under pathological conditions, “too much” motility may cause premature death. Studies over the past few years have revealed that ion channels are essential for cell motility. This review highlights the importance of K+ channels in regulating cell motility.
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12

Cragg, Peter J. "Artificial Transmembrane Channels for Sodium and Potassium." Science Progress 85, no. 3 (2002): 219–41. http://dx.doi.org/10.3184/003685002783238780.

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Transport of alkali metals, particularly sodium and potassium, across cell membranes is an essential function performed by special proteins that enable cells to regulate inter- and extracellular ion concentrations with exceptional selectivity. The importance of these channel-forming proteins has led to researchers emulating of their structural features: an ion-specific filter and conduction at rates up to 108 ions per second. Synthetic helical and cyclic polypeptides form channels, however, the specificity of ion transport is often low. Ion-specific macrocycles have been used as filters from w
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13

Beacham, Daniel W., Trillium Blackmer, Michael O’ Grady, and George T. Hanson. "Cell-Based Potassium Ion Channel Screening Using the FluxOR™ Assay." Journal of Biomolecular Screening 15, no. 4 (2010): 441–46. http://dx.doi.org/10.1177/1087057109359807.

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FluxOR™ technology is a cell-based assay used for high-throughput screening measurements of potassium channel activity. Using thallium influx as a surrogate indicator of potassium ion channel activity, the FluxOR™ Potassium Ion Channel Assay is based on the activation of a novel fluorescent dye. This indicator reports channel activity with a large fluorogenic response and is proportional to the number of open potassium channels on the cell, making it extremely useful for studying K+ channel targets. In contrast to BTC-AM ester, FluxOR™ dye is roughly 10-fold more thallium sensitive, requiring
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14

Pleinis, John M., Logan Norrell, Radha Akella, et al. "WNKs are potassium-sensitive kinases." American Journal of Physiology-Cell Physiology 320, no. 5 (2021): C703—C721. http://dx.doi.org/10.1152/ajpcell.00456.2020.

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With no lysine (K) (WNK) kinases regulate epithelial ion transport in the kidney to maintain homeostasis of electrolyte concentrations and blood pressure. Chloride ion directly binds WNK kinases to inhibit autophosphorylation and activation. Changes in extracellular potassium are thought to regulate WNKs through changes in intracellular chloride. Prior studies demonstrate that in some distal nephron epithelial cells, intracellular potassium changes with chronic low- or high-potassium diet. We, therefore, investigated whether potassium regulates WNK activity independent of chloride. We found de
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15

Fox, J. A., B. A. Pfeffer, and G. L. Fain. "Single-channel recordings from cultured human retinal pigment epithelial cells." Journal of General Physiology 91, no. 2 (1988): 193–222. http://dx.doi.org/10.1085/jgp.91.2.193.

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We have applied patch-clamp techniques to on-cell and excised-membrane patches from human retinal pigment epithelial cells in tissue culture. Single-channel currents from at least four ion channel types were observed: three or more potassium-selective channels with single-channel slope conductances near 100, 45, and 25 pS as measured in on-cell patches with physiological saline in the pipette, and a relatively nonselective channel with subconductance states, which has a main-state conductance of approximately 300 pS at physiological ion concentrations. The permeability ratios, PK/PNa, measured
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16

Hambleton, T. A., J. R. Bourke, G. J. Huxham, and S. W. Manley. "Sodium dependence of the thyrotrophin-induced depolarization in cultured porcine thyroid cells." Journal of Endocrinology 108, no. 2 (1986): 225–30. http://dx.doi.org/10.1677/joe.0.1080225.

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ABSTRACT Cultured porcine thyroid cells exhibit a resting membrane potential of about − 73 mV and depolarize to about − 54 mV on exposure to TSH. The depolarizing response to TSH was preserved in a medium consisting only of inorganic salts and buffers, but was abolished in sodium-free medium, demonstrating dependence on an inward sodium current. Increasing the potassium concentration of the medium resulted in a reduction in the resting membrane potential of 60 mV per tenfold change in potassium concentration, and a diminished TSH response. A hyperpolarizing TSH response was observed in a sodiu
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17

Herranz, Carmen, Luis M. Cintas, Pablo E. Hernández, Gert N. Moll, and Arnold J. M. Driessen. "Enterocin P Causes Potassium Ion Efflux from Enterococcus faecium T136 Cells." Antimicrobial Agents and Chemotherapy 45, no. 3 (2001): 901–4. http://dx.doi.org/10.1128/aac.45.3.901-904.2001.

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ABSTRACT Enterocin P is a bacteriocin produced by Enterococcus faecium P13. We studied the mechanism of its bactericidal action using enterocin-P-sensitive E. faecium T136 cells. The bacteriocin is incapable of dissipating the transmembrane pH gradient. On the other hand, depending on the buffer used, enterocin P dissipates the transmembrane potential. Enterocin P efficiently elicits efflux of potassium ions, but not of intracellularly accumulated anions like phosphate and glutamate. Taken together, these data demonstrate that enterocin P forms specific, potassium ion-conducting pores in the c
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18

Ubels, John L., Rachel E. Van Dyken, Julienne R. Louters, Mark P. Schotanus, and Loren D. Haarsma. "Potassium ion fluxes in corneal epithelial cells exposed to UVB." Experimental Eye Research 92, no. 5 (2011): 425–31. http://dx.doi.org/10.1016/j.exer.2011.02.019.

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19

Harjes, Daniel I., J. Matthew Dubach, Anthony Rosenzweig, Saumya Das, and Heather A. Clark. "Ion-Selective Optodes Measure Extracellular Potassium Flux in Excitable Cells." Macromolecular Rapid Communications 31, no. 2 (2009): 217–21. http://dx.doi.org/10.1002/marc.200900297.

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20

Russell, John M. "Sodium-Potassium-Chloride Cotransport." Physiological Reviews 80, no. 1 (2000): 211–76. http://dx.doi.org/10.1152/physrev.2000.80.1.211.

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Obligatory, coupled cotransport of Na+, K+, and Cl− by cell membranes has been reported in nearly every animal cell type. This review examines the current status of our knowledge about this ion transport mechanism. Two isoforms of the Na+-K+-Cl− cotransporter (NKCC) protein (∼120–130 kDa, unglycosylated) are currently known. One isoform (NKCC2) has at least three alternatively spliced variants and is found exclusively in the kidney. The other (NKCC1) is found in nearly all cell types. The NKCC maintains intracellular Cl− concentration ([Cl−]i) at levels above the predicted electrochemical equi
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21

Rane, S. G. "A Ca2(+)-activated K+ current in ras-transformed fibroblasts is absent from nontransformed cells." American Journal of Physiology-Cell Physiology 260, no. 1 (1991): C104—C112. http://dx.doi.org/10.1152/ajpcell.1991.260.1.c104.

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Biochemical similarities between ras proteins and the GTP-binding proteins and correlation of ras-induced cell transformation with altered transmembrane cation fluxes indicate that ras proteins may act to modulate ion channel activity. To test this idea, whole cell, tight-seal, patch-clamp recording was used to compare macroscopic currents of ras-transformed fibroblasts with currents of their nontransformed counterparts. A prominent calcium-activated, voltage-independent potassium current was observed in 83-100% of cells from three separate fibroblast lines transformed by two different oncogen
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22

Aditya, Grahita, Hikmah Nuraini, and Whinahyu Aji Sekarini. "Pengaruh Material Konservasi Kolostrum terhadap Pelepasan Ion Ni." Jurnal Teknosains 9, no. 1 (2019): 12. http://dx.doi.org/10.22146/teknosains.37727.

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Nickel in orthodontic bracket will be released immediately in the oral cavity. The release of Ni ion may trigger type IV hypersensitivity reaction. Colostrum has a high content of lactoferrin which can inhibit T cells proliferation after nickel sensitization, and decrease oxidative stress. Adding potassium sorbat 0.5%, or fermentation of colostrum may extend colostrum storage. The purpose of this research is to know the difference of nickel ion release in colostrum with 0.5% potassium sorbat addition and fermented colostrum. Methods of the study were laboratory experimental with four groups, c
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23

White, H. Steve, Sien Yao Chow, Y. C. Yen-Chow, and Dixon M. Woodbury. "Effect of elevated potassium on the ion content of mouse astrocytes and neurons." Canadian Journal of Physiology and Pharmacology 70, S1 (1992): S263—S268. http://dx.doi.org/10.1139/y92-271.

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Potassium is tightly regulated within the extracellular compartment of the brain. Nonetheless, it can increase 3- to 4-fold during periods of intense seizure activity and 10- to 20-fold under certain pathological conditions such as spreading depression. Within the central nervous system, neurons and astrocytes are both affected by shifts in the extracellular concentration of potassium. Elevated potassium can lead to a redistribution of other ions (e.g., calcium, sodium, chloride, hydrogen, etc.) within the cellular compartment of the brain. Small shifts in the extracellular potassium concentra
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24

Morris, A. P., D. V. Gallacher, C. M. Fuller, and J. Scott. "Cholinergic Receptor-regulation of Potassium Channels and Potassium Transport in Human Submandibular Acinar Cells." Journal of Dental Research 66, no. 2 (1987): 541–46. http://dx.doi.org/10.1177/00220345870660022601.

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The cholinergic receptor-regulation of K+ transport was studied in human submandibular glands. Acetylcholine stimulation 10 μmol/L results in an increase in membrane permeability (86Rb+ efflux) for, and a net efflux of, K+ ions from the glandular tissue. In the post-stimulus period, there is a net re-uptake of K+ ions into the tissue. Patch-clamp electrophysiological techniques were employed to demonstrate the presence of a large conductance K+ selective ion channel in the basolateral membranes of isolated human submandibular acinar cells. The patch-clamp results indicate that this voltage- an
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25

Wolowyk, M. W., and J. C. Ellory. "Changes in the cation composition and active K+ transport in the red cells of fetal sheep prepartum." Canadian Journal of Physiology and Pharmacology 63, no. 11 (1985): 1454–59. http://dx.doi.org/10.1139/y85-238.

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The red blood cells of lambs, genotypically low potassium type, undergo a transition from high potassium to low potassium cell type from parturition onwards. This involves gradual changes in cell ion content, sodium pump activity, and ouabain binding. In the present study we investigated the properties of fetal red blood cells from 30 days prepartum using the chronically cannulated pregnant ewe preparation. We demonstrate that intracellular sodium increases and potassium decreases from −30 days onwards. Sodium pump activity monitored either by tracer potassium influx or ouabain binding is mark
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26

Deftu, Alexandru-Florian, Violeta Ristoiu, and Marc Rene Suter. "Intrathecal Administration of CXCL1 Enhances Potassium Currents in Microglial Cells." Pharmacology 101, no. 5-6 (2018): 262–68. http://dx.doi.org/10.1159/000486865.

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The functioning of microglial cells inside the central nervous system depends on their ion channels expression. Microglia are capable of synthesizing different cytokines and chemokines, including CXCL1, and responding to their action via specific receptors. In this study, we explore the effect of intrathecal injection of CXCL1 on potassium currents, expressed in CX3CR1-Green Fluorescent Protein labeled microglia in transgenic mice. The results showed that CXCL1 hyperpolarized the cells by enhancing inward rectifying potassium currents and increasing the membrane area, suggesting an activating
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27

Chirra, Martina, Hannah S. Newton, Vaibhavkumar S. Gawali, Trisha M. Wise-Draper, Ameet A. Chimote, and Laura Conforti. "How the Potassium Channel Response of T Lymphocytes to the Tumor Microenvironment Shapes Antitumor Immunity." Cancers 14, no. 15 (2022): 3564. http://dx.doi.org/10.3390/cancers14153564.

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Competent antitumor immune cells are fundamental for tumor surveillance and combating active cancers. Once established, tumors generate a tumor microenvironment (TME) consisting of complex cellular and metabolic elements that serve to suppress the function of antitumor immune cells. T lymphocytes are key cellular elements of the TME. In this review, we explore the role of ion channels, particularly K+ channels, in mediating the suppressive effects of the TME on T cells. First, we will review the complex network of ion channels that mediate Ca2+ influx and control effector functions in T cells.
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28

Wu, Yuhan, Yang Xu, Yueliang Li, et al. "Unexpected intercalation-dominated potassium storage in WS2 as a potassium-ion battery anode." Nano Research 12, no. 12 (2019): 2997–3002. http://dx.doi.org/10.1007/s12274-019-2543-0.

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Abstract Unexpected intercalation-dominated process is observed during K+ insertion in WS2 in a voltage range of 0.01–3.0 V. This is different from the previously reported two-dimensional (2D) transition metal dichalcogenides that undergo a conversion reaction in a low voltage range when used as anodes in potassium-ion batteries. Charge/discharge processes in the K and Na cells are studied in parallel to demonstrate the different ion storage mechanisms. The Na+ storage proceeds through intercalation and conversion reactions while the K+ storage is governed by an intercalation reaction. Owing t
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29

Zhao, Ke-Qing, Guoxiang Xiong, Morgan Wilber, Noam A. Cohen, and James L. Kreindler. "A role for two-pore K+ channels in modulating Na+ absorption and Cl− secretion in normal human bronchial epithelial cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 302, no. 1 (2012): L4—L12. http://dx.doi.org/10.1152/ajplung.00102.2011.

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Mucociliary clearance is the primary innate physical defense mechanism against inhaled pathogens and toxins. Vectorial ion transport, primarily sodium absorption and anion secretion, by airway epithelial cells supports mucociliary clearance. This is evidenced by diseases of abnormal ion transport such as cystic fibrosis and pseudohypoaldosteronism that are characterized by changes in mucociliary clearance. Sodium absorption and chloride secretion in human bronchial epithelial cells depend on potassium channel activity, which creates a favorable electrochemical gradient for both by hyperpolariz
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30

Park, Kang-Sik, Jae-Won Yang, Edward Seikel, and James S. Trimmer. "Potassium Channel Phosphorylation in Excitable Cells: Providing Dynamic Functional Variability to a Diverse Family of Ion Channels." Physiology 23, no. 1 (2008): 49–57. http://dx.doi.org/10.1152/physiol.00031.2007.

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Phosphorylation of potassium channels affects their function and plays a major role in regulating cell physiology. Here, we review previous studies of potassium channel phosphorylation, focusing first on studies employing site-directed mutagenesis of recombinant channels expressed in heterologous cells. We then discuss recent mass spectrometric-based approaches to identify and quantify phosphorylation at specific sites on native and recombinant potassium channels, and newly developed mass spectrometric-based techniques that may prove beneficial to future studies of potassium channel phosphoryl
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31

Chandra, S., E. P. Kable, G. H. Morrison, and W. W. Webb. "Calcium sequestration in the Golgi apparatus of cultured mammalian cells revealed by laser scanning confocal microscopy and ion microscopy." Journal of Cell Science 100, no. 4 (1991): 747–52. http://dx.doi.org/10.1242/jcs.100.4.747.

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Co-localization of the elements calcium, potassium, sodium and magnesium with sequestering organelles has been achieved by application of two microscopy techniques on the same cell. Organelles were first localized by laser scanning confocal microscopy (LSCFM) using fluorescent organelle stains. The same cells were then analyzed for elemental distribution with ion microscopy. This approach has identified a perinuclear region of prominent total calcium concentration with the Golgi apparatus. Live cells were fluorescently stained with C6-NBD-ceramide for labeling the Golgi apparatus prior to cryo
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32

Rodriguez-Navarro, A., M. R. Blatt, and C. L. Slayman. "A potassium-proton symport in Neurospora crassa." Journal of General Physiology 87, no. 5 (1986): 649–74. http://dx.doi.org/10.1085/jgp.87.5.649.

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Combined ion flux and electrophysiological measurements have been used to characterized active transport of potassium by cells of Neurospora crassa that have been moderately starved of K+ and then maintained in the presence of millimolar free calcium ions. These conditions elicit a high-affinity (K1/2 = 1-10 microM) potassium uptake system that is strongly depolarizing. Current-voltage measurements have demonstrated a K+-associated inward current exceeding (at saturation) half the total current normally driven outward through the plasma membrane proton pump. Potassium activity ratios and fluxe
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33

Roden, D. M., and A. L. George. "Structure and function of cardiac sodium and potassium channels." American Journal of Physiology-Heart and Circulatory Physiology 273, no. 2 (1997): H511—H525. http://dx.doi.org/10.1152/ajpheart.1997.273.2.h511.

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The application of patch-clamp and molecular approaches has resulted in an increasingly refined understanding of the molecular entities underlying cardiac sodium and potassium currents. The sodium current results from expression of a single large alpha-subunit, whereas multiple potassium currents and potassium channel alpha-subunits have been identified. Recapitulation of some ion currents in heterologous expression systems requires not only expression of alpha-subunits but also ancillary (beta) subunits. Domains common to functions such as activation, inactivation, and drug block are now bein
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34

Park, Jong-Hyeok, and Jin-Soo Park. "KOH-doped Porous Polybenzimidazole Membranes for Solid Alkaline Fuel Cells." Energies 13, no. 3 (2020): 525. http://dx.doi.org/10.3390/en13030525.

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In this study the preparation and properties of potassium hydroxide-doped meta-polybenzimidazole membranes with 20–30 μm thickness are reported as anion conducting polymer electrolyte for application in fuel cells. Dibutyl phthalate as porogen forms an asymmetrically porous structure of membranes along thickness direction. One side of the membranes has a dense skin layer surface with 1.5–15 μm and the other side of the membranes has a porous one. It demonstrated that ion conductivity of the potassium hydroxide-doped porous membrane with the porogen content of 47 wt.% (0.090 S cm−1), is 1.4 tim
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35

Lin, Yechao, Jiacen Liu, Liluo Shi, et al. "Dual stabilization in potassium Prussian blue and cathode/electrolyte interface enables advanced potassium-ion full-cells." Journal of Colloid and Interface Science 623 (October 2022): 1–8. http://dx.doi.org/10.1016/j.jcis.2022.05.023.

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36

Nilius, B., T. B�hm, and W. Wohlrab. "Properties of a potassium-selective ion channel in human melanoma cells." Pfl�gers Archiv European Journal of Physiology 417, no. 3 (1990): 269–77. http://dx.doi.org/10.1007/bf00370992.

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37

Kim, Hyun Jong, Seorin Park, Hui Young Shin та ін. "Inhibitory effects of α-Mangostin on T cell cytokine secretion via ORAI1 calcium channel and K+ channels inhibition". PeerJ 9 (3 березня 2021): e10973. http://dx.doi.org/10.7717/peerj.10973.

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Background As one of the main components of mangosteen (Garcinia mangostana), a tropical fruit, α-mangostin has been reported to have numerous pharmacological benefits such as anti-cancer, anti-inflammatory, and anti-allergic effects through various mechanisms of action. The effects of α-mangostin on intracellular signaling proteins is well studied, but the effects of α-mangostin on ion channels and its physiological effects in immune cells are unknown. Generation of intracellular calcium signaling is a fundamental step for T cell receptor stimulation. This signaling is mediated not only by th
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38

Kashtoh, Hamdy, and Kwang-Hyun Baek. "Structural and Functional Insights into the Role of Guard Cell Ion Channels in Abiotic Stress-Induced Stomatal Closure." Plants 10, no. 12 (2021): 2774. http://dx.doi.org/10.3390/plants10122774.

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A stomatal pore is formed by a pair of specialized guard cells and serves as a major gateway for water transpiration and atmospheric CO2 influx for photosynthesis in plants. These pores must be tightly controlled, as inadequate CO2 intake and excessive water loss are devastating for plants. When the plants are exposed to extreme weather conditions such as high CO2 levels, O3, low air humidity, and drought, the turgor pressure of the guard cells exhibits an appropriate response against these stresses, which leads to stomatal closure. This phenomenon involves a complex network of ion channels an
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39

Nakamura, Kazuyoshi, Hikaru Hayashi, and Manabu Kubokawa. "Proinflammatory Cytokines and Potassium Channels in the Kidney." Mediators of Inflammation 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/362768.

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Proinflammatory cytokines affect several cell functions via receptor-mediated processes. In the kidney, functions of transporters and ion channels along the nephron are also affected by some cytokines. Among these, alteration of activity of potassium ion (K+) channels induces changes in transepithelial transport of solutes and water in the kidney, since K+channels in tubule cells are indispensable for formation of membrane potential which serves as a driving force for the transepithelial transport. Altered K+channel activity may be involved in renal cell dysfunction during inflammation. Althou
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40

Gaber, R. F., C. A. Styles, and G. R. Fink. "TRK1 encodes a plasma membrane protein required for high-affinity potassium transport in Saccharomyces cerevisiae." Molecular and Cellular Biology 8, no. 7 (1988): 2848–59. http://dx.doi.org/10.1128/mcb.8.7.2848-2859.1988.

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We identified a 180-kilodalton plasma membrane protein in Saccharomyces cerevisiae required for high-affinity transport (uptake) of potassium. The gene that encodes this putative potassium transporter (TRK1) was cloned by its ability to relieve the potassium transport defect in trk1 cells. TRK1 encodes a protein 1,235 amino acids long that contains 12 potential membrane-spanning domains. Our results demonstrate the physical and functional independence of the yeast potassium and proton transport systems. TRK1 is nonessential in S. cerevisiae and maps to a locus unlinked to PMA1, the gene that e
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41

Gaber, R. F., C. A. Styles, and G. R. Fink. "TRK1 encodes a plasma membrane protein required for high-affinity potassium transport in Saccharomyces cerevisiae." Molecular and Cellular Biology 8, no. 7 (1988): 2848–59. http://dx.doi.org/10.1128/mcb.8.7.2848.

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We identified a 180-kilodalton plasma membrane protein in Saccharomyces cerevisiae required for high-affinity transport (uptake) of potassium. The gene that encodes this putative potassium transporter (TRK1) was cloned by its ability to relieve the potassium transport defect in trk1 cells. TRK1 encodes a protein 1,235 amino acids long that contains 12 potential membrane-spanning domains. Our results demonstrate the physical and functional independence of the yeast potassium and proton transport systems. TRK1 is nonessential in S. cerevisiae and maps to a locus unlinked to PMA1, the gene that e
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42

Dong, J., and N. A. Delamere. "Protein kinase C inhibits Na(+)-K(+)-2Cl- cotransporter activity in cultured rabbit nonpigmented ciliary epithelium." American Journal of Physiology-Cell Physiology 267, no. 6 (1994): C1553—C1560. http://dx.doi.org/10.1152/ajpcell.1994.267.6.c1553.

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We examined the regulation of Na(+)-K(+)-2Cl- transporter activity by protein kinase C (PKC) in a cell line derived from rabbit nonpigmented ciliary epithelium. Na(+)-K(+)-2Cl- cotransporter activity was measured as the rate of bumetanide-sensitive potassium (86Rb) transport. Phorbol 12,13-dibutyrate (PBDu) was used to activate PKC. PBDu inhibited bumetanide-sensitive potassium (86Rb) uptake, with a half-maximal inhibitory concentration of approximately 0.1 microM. The inhibitory effect of PBDu on potassium uptake by the N(+)-K(+)-2Cl- cotransporter was abolished by PCK downregulation and dimi
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43

Pérez-García, M. Teresa, Pilar Cidad, and José R. López-López. "The secret life of ion channels: Kv1.3 potassium channels and proliferation." American Journal of Physiology-Cell Physiology 314, no. 1 (2018): C27—C42. http://dx.doi.org/10.1152/ajpcell.00136.2017.

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Kv1.3 channels are involved in the switch to proliferation of normally quiescent cells, being implicated in the control of cell cycle in many different cell types and in many different ways. They modulate membrane potential controlling K+ fluxes, sense changes in potential, and interact with many signaling molecules through their intracellular domains. From a mechanistic point of view, we can describe the role of Kv1.3 channels in proliferation with at least three different models. In the “membrane potential model,” membrane hyperpolarization resulting from Kv1.3 activation provides the drivin
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44

Pozdnyakov, Ilya, Olga Matantseva, and Sergei Skarlato. "Consensus channelome of dinoflagellates revealed by transcriptomic analysis sheds light on their physiology." Algae 36, no. 4 (2021): 315–26. http://dx.doi.org/10.4490/algae.2021.36.12.2.

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Ion channels are membrane protein complexes mediating passive ion flux across the cell membranes. Every organism has a certain set of ion channels that define its physiology. Dinoflagellates are ecologically important microorganisms characterized by effective physiological adaptability, which backs up their massive proliferations that often result in harmful blooms (red tides). In this study, we used a bioinformatics approach to identify homologs of known ion channels that belong to 36 ion channel families. We demonstrated that the versatility of the dinoflagellate physiology is underpinned by
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45

Dey, Sonjoy, and Gurpreet Singh. "WS2 Nanosheet Loaded Silicon-Oxycarbide Electrode for Sodium and Potassium Batteries." Nanomaterials 12, no. 23 (2022): 4185. http://dx.doi.org/10.3390/nano12234185.

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Transition metal dichalcogenides (TMDs) such as the WS2 have been widely studied as potential electrode materials for lithium-ion batteries (LIB) owing to TMDs’ layered morphology and reversible conversion reaction with the alkali metals between 0 to 2 V (v/s Li/Li+) potentials. However, works involving TMD materials as electrodes for sodium- (NIBs) and potassium-ion batteries (KIBs) are relatively few, mainly due to poor electrode performance arising from significant volume changes and pulverization by the larger size alkali-metal ions. Here, we show that Na+ and K+ cyclability in WS2 TMD is
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46

Hotchkiss, Karin, Margaret Harvey, Mary Pacheco, and Bernd Sokolowski. "Ion channel proteins in mouse and human vestibular tissue." Otolaryngology–Head and Neck Surgery 132, no. 6 (2005): 916–23. http://dx.doi.org/10.1016/j.otohns.2005.01.022.

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BACKGROUND AND OBJECTIVE: Electrical activity in hair cells and neurons of the inner ear is necessary for the transduction and modulation of stimuli that impinge on the cochlea and vestibular endorgans of the inner ear. The underlying basis of this activity is pore-forming proteins in the membrane of excitable cells that allow the influx and efflux of various ions, including Na+, Ca2+, and K+, among others. These channels are critical to both electrical activity as well as the development of excitable cells because they may initiate long-term signals that are important in the maintenance and s
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Schär-Zammaretti, Prisca, Urs Ziegler, Ian Forster, Peter Groscurth, and Ursula E. Spichiger-Keller. "Potassium-Selective Atomic Force Microscopy on Ion-Releasing Substrates and Living Cells." Analytical Chemistry 74, no. 16 (2002): 4269–74. http://dx.doi.org/10.1021/ac025605n.

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48

Fukuda, Koichiro, Yuji Michisuji, Kiyoshi Kamiya, Takeshi Himeno, Takao Kiyota, and Torao Ishida. "Potassium ion enhances tissue-type plasminogen activator expression in cultured HEL cells." Journal of Fermentation and Bioengineering 76, no. 2 (1993): 111–16. http://dx.doi.org/10.1016/0922-338x(93)90066-h.

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49

Pappone, P. A., and M. T. Lucero. "Potassium channel block does not affect metabolic responses of brown fat cells." American Journal of Physiology-Cell Physiology 262, no. 3 (1992): C678—C681. http://dx.doi.org/10.1152/ajpcell.1992.262.3.c678.

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Hormonally stimulated brown fat cells are capable of extremely high metabolic rates, making them an excellent system in which to examine the role of plasma membrane ion channels in cell metabolism. We have previously shown that brown fat cell membranes have both voltage-gated and calcium-activated potassium channels (Voltage-gated potassium channels in brown fat cells. J. Gen. Physiol. 93: 451-472, 1989; Membrane responses to norepinephrine in cultured brown fat cells. J. Gen. Physiol. 95: 523-544, 1990). Currents through both the voltage-activated potassium channels, IK,V, and the calcium-act
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Khudyshkina, Anna D., Iurii Panasenko, Philip Henkel, Christian Njel, and Fabian Jeschull. "(Invited) Degradation Processes at the Potassium Hexacyanoferrate Electrode in Potassium-Ion Batteries." ECS Meeting Abstracts MA2022-02, no. 59 (2022): 2205. http://dx.doi.org/10.1149/ma2022-02592205mtgabs.

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Prussian blue analogues (PBAs)[1] with the general composition A2M[Fe(CN)6] (A: alkali metal; M: Fe, Mn, etc) are an attractive positive electrode for potassium-ion batteries, owing to their chemical composition based on widely abundant materials, ease of synthesis, high electrochemical reversibility and higher average potential compared to its sodium congener [1]. The combination of a PBA electrode with a graphite negative electrode in a full cell configuration showed great promise as post-Li battery system. However, the upper cut-off potentials of K2Fe[Fe(CN)6] and K2Mn[Fe(CN)6] pose serious
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