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Journal articles on the topic 'Potentially malignant disorders of oral cavity'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Shaji, Jilssa, Greeshma Balakrishnan, Nilofer Halim, Lakshmi Jayaraj, and Rumaisha . "Potentially -malignant disorders." Journal of Otolaryngology-ENT Research 14, no. 2 (2022): 44–47. http://dx.doi.org/10.15406/joentr.2022.14.00504.

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It is estimated that more than one million new oral cancer cases are being detected annually in the Indian subcontinent, of which 90% are oral squamous cell carcinoma (OSCC). Oral potentially malignant disorder (OPMD) are associated with increased rate of occurrence of OSCC of lips or oral cavity. Transformation of oral cancer from OPMD is common, especially in South Asian countries like India, where tobacco and arecanut consumption is prevalent. Early diagnosis and timely treatment of PMD’s may help to prevent its malignant transformation into oral cancer. The aim of the article is to highlig

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2

Anthony, George, BS Sreenivasan, S. Sunil, et al. "Potentially Malignant Disorders of Oral Cavity." Oral and Maxillofacial Pathology Journal 2, no. 1 (2011): 95–100. https://doi.org/10.5281/zenodo.167066.

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Even though rapid advances have been made in the field of medicine and surgery, cancer is the leading cause for human mortality. It is estimated that more than one million new oral cancer cases are being detected annually in the Indian subcontinent, of which 90% are oral squamous cell carcinomas (OSCC). 60-70% of the Indian patients presented for treatment only in the advanced stage of oral cancer leading to the high mortality rate. Lack of public awareness about the signs, symptoms and risk factors, along with the absence of knowledge for early detection by health-care providers are believed

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3

Ojeda, David, Michaell A. Huber, and Alexander R. Kerr. "Oral Potentially Malignant Disorders and Oral Cavity Cancer." Dermatologic Clinics 38, no. 4 (2020): 507–21. http://dx.doi.org/10.1016/j.det.2020.05.011.

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4

Dr., M. Kaviya, M. Sathish Kumar Dr., Dr.M.Lavanya, M. Keerthana Dr., S. Kanimozhi Dr., and P. Karthika Dr. "Red Lesions of Oral Cavity: A Review." International Journal of Innovative Science and Research Technology 8, no. 3 (2023): 1603–8. https://doi.org/10.5281/zenodo.7793037.

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The most common oral lesions are erythematous. It will be from benign reactive or immunologically-mediated disorders to malignant diseases. Red patches of the oral mucosa constitute an important group of disorders arising from a diverse spectrum of conditions ranging from traumatic lesions, infectious diseases, systemic and local immune-mediated lesions, to potentially malignant disorders or a neoplasm. Oral erythroplakia is considered a rare potential malignant lesion of the oral cavity. Most red oral lesions are associated with inflammation. Some are potentially malignant, especially erythro

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5

Meenapriya M and Deepika Rajendran. "Prevalence of oral potentially malignant disorders among adult population: A retrospective study." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 671–79. http://dx.doi.org/10.26452/ijrps.v11ispl4.4016.

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Oral potentially malignant disorders refer to both the precancerous lesions and precancerous conditions of the oral cavity. They possess the risk of cancer development in the oral cavity. Precancerous lesions and conditions are associated with various causative factors such as smoking, smokeless forms of tobacco etc. Early detection of oral, potentially malignant disorders can reduce the risk of development into oral cancer. Therefore, the purpose of this study is to find out the prevalence of oral, potentially malignant disorders among the adult population. The records were obtained through D

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6

Anushree, Rathore1, Kumar1 Amit, Abu Bakr Siddique1 Mohammad, Mehrotra1 Rani, Singh Choudhary2 Deepak, and Gupta3 Ankit. "Marking the Micro Details in Potentially Malignant Disorders of Oral Cavity." People's Journal of Scientific Research 16, no. 1 (2023): 1–6. https://doi.org/10.5281/zenodo.8077018.

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Background- The malignancy of the oral cavity constitutes the most important group of malignancies in South and Southeast Asia.The risk increases with the use of tobacco products. Materials & Methods- Micronuclei frequency scoring was used as a biomarker to identify different potentially malignant disorders. Results- Mean micronuclei index was found higher using Hematoxylin and Eosin stain than Papanicolaou's stainand May Grunwald's stain. Conclusion- We concluded that the micronuclei frequencies in oral exfoliated epithelial cells using three different stains- Hematoxylin and Eosi

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7

Tang, Kai Dun, Lilian Menezes, Kurt Baeten, et al. "Oral HPV16 Prevalence in Oral Potentially Malignant Disorders and Oral Cavity Cancers." Biomolecules 10, no. 2 (2020): 223. http://dx.doi.org/10.3390/biom10020223.

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The role of human papillomavirus type 16 (HPV16) in oral potentially malignant disorders (OPMD) and oral cavity carcinoma (OC) is still under debate. We investigated HPV16 prevalence in unstimulated saliva, oral rinse samples, oral swabs and tumour biopsies collected from OPMD (n = 83) and OC (n = 106) patients. HPV16 genotype, viral load, physical status (episomal vs. integrated) and tumour p16INK4a expression were determined. Oral HPV16 prevalence was higher in OC than in OPMD, but this difference was not statistically significant (7.5% (8/106) versus 3.6% (3/83), odds ratio (OR): 2.18, 95%

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8

Ajay, K. Pillai, Raghuvanshi Vikalp, Dubey Siddarth, Kumar Rahmatker Akshay, Sahoo Anumita, and Kawadkar Dhwani. "Prevalence of Potentially Malignant Disorders of the Oral Cavity in Bhopal." PJSR 13, no. 2 (2020): 1–9. https://doi.org/10.5281/zenodo.8216905.

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Oral cancer is generally preceded by some benign lesions for a varying length of time. Many of them show high potential to become cancers, and therefore termed “precancerous”. Even though only small proportion of precancer actually progress to oral cancer, this development forms a source for over 70% of oral cancers in India Aims/Objectives: An epidemiological survey was conducted in the population of Bhopal city to estimate the prevalence of potentially malignant disorder of the oral cavity. Results: Our study comprised of total 2509 samples out of which males were 1354 (54%) and

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9

Shukla, Anirudh. "Potentially Malignant Disorders of the Oral Cavity: A Clinical Study." Indian Journal of Otolaryngology and Head & Neck Surgery 66, no. 1 (2013): 79–85. http://dx.doi.org/10.1007/s12070-013-0680-4.

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10

Varoni, Elena Maria, and Lia Rimondini. "Oral Microbiome, Oral Health and Systemic Health: A Multidirectional Link." Biomedicines 10, no. 1 (2022): 186. http://dx.doi.org/10.3390/biomedicines10010186.

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The oral cavity can be regarded as the mirror of systemic health, since many systemic diseases may have manifestations in the oral cavity, as in the case, among oral, potentially malignant disorders, of lupus erythematosus oral lichenoid lesions, and, vice-versa, oral diseases may affect systemic health, impairing patient’s nutrition and wellbeing, reducing the quality of life and increasing stress and anxiety [...]

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11

Narula, Tania. "Molecular Insight Into Pathogenesis of Potentially Malignant Disorders of Oral Cavity." International Journal of Cancer Epidemiology and Research 1, no. 1 (2017): 11–16. http://dx.doi.org/10.25141/2572-7664-2017-1.0011.

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12

Sarode, Sachin C., Gargi S. Sarode, Swarada Karmarkar, and Jagdish V. Tupkari. "A new classification for potentially malignant disorders of the oral cavity." Oral Oncology 47, no. 9 (2011): 920–21. http://dx.doi.org/10.1016/j.oraloncology.2011.06.005.

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13

Chole, Revant H., and Swati Balsaraf. "Prevention and control of oral potentially malignant disorders." International Journal of Oral Health Sciences 14, no. 2 (2024): 45–48. https://doi.org/10.4103/ijohs.ijohs_8_24.

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Abstract Oral cavity cancer accounts for approximately 4% of all malignancies and is a significant worldwide health problem. In Southeast Asia, oral cancer account for 40% of all cancers. It is the consensus of health promotion researchers that culturally specific (CS) interventions are important in addressing smoking-related health disparities. Equivocal evidence also exists for tobacco interventions that do not attend to culture specific characteristics, that is, traditional or non-CS interventions. Tobacco use is one of the major public health problems in the world, resulting in 5.4 million

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14

Swain, Santosh Kumar. "Premalignant lesions of the oral cavity: current perspectives." International Journal of Research in Medical Sciences 9, no. 6 (2021): 1816. http://dx.doi.org/10.18203/2320-6012.ijrms20212259.

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Premalignant lesions of the oral cavity are also called as potentially malignant disorders. The common premalignant lesions of the oral cavity include leukoplakia, oral submucous fibrosis (OSMF) and oral erythroplakia. These lesions have a very high malignant transformation rate. The exact etiological factors for development of the premalignant lesions of the oral cavity are not fully understood till date. Use of tobacco, alcohol drinking, chewing betel quid containing areca nut and solar rays are important etiological factors for resulting the premalignant lesions of the oral cavity. Early di

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15

Onofrei, Bianca-Andreea, Cristina Popa, Ana Maria Sciuca, et al. "POTENTIALLY MALIGNANT LESIONS IN THE ORAL CAVITY: A RETROSPECTIVE ANALYSIS." Romanian Journal of Oral Rehabilitation 16, no. 2 (2024): 326–33. https://doi.org/10.62610/rjor.2024.2.16.29.

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The study aimed to present the characteristics of the three most prevalent oral potentially malignant disorders, leukoplakia, oral lichen planus (OLP), and actinic cheilitis, using data from 62 patients collected at the “Sfântul Spiridon” Emergency Clinical Hospital in Iași, Romania, between January 2015 and January 2023. The results revealed a higher prevalence of these lesions among older adults, particularly those over 50 years old, and a significant gender disparity in the incidence of actinic cheilitis, which was more common in males (68%). Leukoplakia was frequently observed on the tongu

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Kolomiiets, S. V., K. O. Udaltsova, and V. I. Shynkevych. "RECOMMENDED TACTICS FOR THE EVALUATION OF POTENTIALLY MALIGNANT DISORDERS IN THE ORAL CAVITY." Ukrainian Dental Almanac, no. 1 (March 21, 2018): 75–78. http://dx.doi.org/10.31718/2409-0255.1.2018.18.

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Since oral cavity, head and neck are relatively well-visualized anatomical sites, the dentists have multifold possibilities for the evaluation of the oral mucosa, face skin, lips, and neck lymph nodes during their routine work. Dentists are the specialists who are able to detect malignant tumors and refer patients to the oncologists. The aim of the article is to compare the clinical recommendations of the Ministry of Healthcare of Ukraine and the recommendation made by the American Dental Association (ADA) in their updated clinical practice guidelines for the evaluation of potentially ma

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Motelica, Cristinela, Gabriela Motelica, Irina Ciochina, et al. "Oral potentially malignant disorders: leukoplakia, erythroplakia, oral submucosal fibrosis. Systematic review of associated risk factors." Journal of Stomatological Medicine, no. 2 (November 2024): 36–42. https://doi.org/10.53530/1857-1328.24.2.04.

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Introduction. Oral potentially malignant disorders (OPMD) represent a heterogeneous group of oral mucosal disorders associated with an increased risk of malignant transformation. The specialty literature indicates that tobacco consumption in various forms, such as smoking products containing tobacco, reverse smoking, chewing tobacco, alcohol consumption, consumption of areca (betel) nuts, are the factors most often involved in the development of OPMD. The aim of the study. Systematic review of scientific researches and clinical trials on risk factors involved in the development of leukoplakia,

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18

Bhatia, Nirav, Yastira Lalla, An N. Vu, and Camile S. Farah. "Advances in Optical Adjunctive Aids for Visualisation and Detection of Oral Malignant and Potentially Malignant Lesions." International Journal of Dentistry 2013 (2013): 1–17. http://dx.doi.org/10.1155/2013/194029.

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Traditional methods of screening for oral potentially malignant disorders and oral malignancies involve a conventional oral examination with digital palpation. Evidence indicates that conventional examination is a poor discriminator of oral mucosal lesions. A number of optical aids have been developed to assist the clinician to detect oral mucosal abnormalities and to differentiate benign lesions from sinister pathology. This paper discusses advances in optical technologies designed for the detection of oral mucosal abnormalities. The literature regarding such devices, VELscope and Identafi, i

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19

SILVA, RICARDO NATã FONSECA, RAíSSA ALBINO DE MATOS, ANA KAROLINE DE CARVALHO ARAÚJO, ELISMAURO FRANCISCO DE MENDONÇA, ALINE CARVALHO BATISTA, and NáDIA DO LAGO COSTA. "EVALUATION OF INFLAMMATORY MARKERS IN POTENTIALLY MALIGNANT DISORDERS OF THE ORAL CAVITY." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 130, no. 3 (2020): e276-e277. http://dx.doi.org/10.1016/j.oooo.2020.04.758.

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20

Lingen, Mark W., Malavika P. Tampi, Olivia Urquhart, et al. "Adjuncts for the evaluation of potentially malignant disorders in the oral cavity." Journal of the American Dental Association 148, no. 11 (2017): 797–813. http://dx.doi.org/10.1016/j.adaj.2017.08.045.

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21

Bhat, Meghashyam, Sreevidya Bhat, Kaye Roberts-Thomson, and Loc Giang Do. "Is Periodontitis Independently Associated with Potentially Malignant Disorders of the Oral Cavity?" Asian Pacific Journal of Cancer Prevention 20, no. 1 (2019): 283–87. http://dx.doi.org/10.31557/apjcp.2019.20.1.283.

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22

Aitken-Saavedra, Juan Pablo, Angélica Diaz Valdivia, Daniela Adorno-Farias, et al. "Frequency and histoclinic pathology of malignant and potentially malignant disorders of oral cavity in Chile." JORDI - Journal of Oral Diagnosis 2 (2017): 1–6. http://dx.doi.org/10.5935/2525-5711.20170029.

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23

Ivasiuc, Irina, Eugen Melnic, Daniela-Elena Costea, and Diana Uncuta. "Oral lichen planus – an oral potentially malignant disorder (OPMD) of the oral cavity." Moldovan Journal of Health Sciences 11, no. 1 (2024): 58–65. http://dx.doi.org/10.52645/mjhs.2024.1.09.

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Introduction. Oral lichen planus is a chronic inflammatory disease of unknown etiology, characterized by recurrent lesions, presenting as reticular lesions, sometimes accompanied by atrophic, erosive, and/or ulcerative areas. Despite being one of the most common conditions affecting the oral mucosa, oral lichen planus remains an ailment with undefined etiology and unclear pathogenesis, imprecise management, and uncertain premalignant potential. Materials and methods. A narrative literature review study was conducted. A bibliographic search was carried out in databases such as PubMed, Hinari, S

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24

Jayasinghe, Ruwan Duminda, and B. S. M. S. Siriwardena. "Clinical Aspects of Oral Cancer and Potentially Malignant Disorders with Special Relevance to South Asia." Annals of Maxillofacial Surgery 14, no. 2 (2024): 128–36. https://doi.org/10.4103/ams.ams_184_24.

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Abstract Early identification of oral potentially malignant disorders (OPMDs) is utmost important to minimise oral cancer incidence as most oral cancers develop from OPMDs. Leucoplakia and oral submucous fibrosis (OSMF) are the most common OPMDs encountered. Erythroplakia is rare but is more serious as it has a very high malignant transformation rate. Clinical presentation of OPMDs can vary according to the type of the disorder as well as with the aetiological agents. OSMF is much prevalent in South and South Asian countries whereas leucoplakia is prevalent all over the world but with differen

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Grover, Sonal, KP Nithin, AnilB Shivappa, Neethu Telagi, and MujibBR Ahmed. "Evaluation of diagnostic reliability of micronuclei in potentially malignant disorders of oral cavity." CHRISMED Journal of Health and Research 1, no. 1 (2014): 15. http://dx.doi.org/10.4103/2348-3334.126776.

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Passerini, Sara, Giulia Babini, Elisabetta Merenda, et al. "Merkel Cell Polyomavirus in the Context of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders." Biomedicines 12, no. 4 (2024): 709. http://dx.doi.org/10.3390/biomedicines12040709.

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Despite recent advances in prevention, detection and treatment, oral squamous cell carcinoma (OSCC) remains a global health concern, strongly associated with environmental and lifestyle risk factors and infection with oncogenic viruses. Merkel Cell Polyomavirus (MCPyV), well known to be the causative agent of Merkel Cell Carcinoma (MCC) has been found in OSCC, suggesting its potential role as a co-factor in the development of oral cavity cancers. To improve our understanding about MCPyV in oral cavities, the detection and analysis of MCPyV DNA, transcripts and miRNA were performed on OSCCs and

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Kioi, Mitomu, Hiroshi Isono, and Shintaro Nakajima. "Abstract 4238: Specific oral microbiome is closely associated with oral potentially malignant disorders and oral squamous cell carcinoma." Cancer Research 83, no. 7_Supplement (2023): 4238. http://dx.doi.org/10.1158/1538-7445.am2023-4238.

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Abstract Background: Bacterial and virus infection may cause pre-malignant and malignant disorder such as hepatocellular carcinoma and cervical cancer. Recent studies reported that oral bacterium is associated with gastric and colon cancer. However, it is not clear yet if the oral microbiome affects the development of pre-malignant disorder in oral cavity and oral cancer. Thus, this study aims to identify the periodontal pathogen candidates involved in the onset and progression of oral squamous cell carcinoma (OSCC). Materials and Methods: Saliva was collected from 112 patients without oral mu

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Cioban, Cosmin Vasile, Stefan Adrian Petrutiu, Daniela Cornelia Condor, and Willi Andrei Uriciuc. "The use of autofluorescence for screening and early detection of oral potentially malignant disorders – A narrative review." Romanian Journal of Stomatology 68, no. 4 (2022): 153–59. http://dx.doi.org/10.37897/rjs.2022.4.5.

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Premalignant lesions of the oral cavity encompass a broad range of pathology and are often comorbid in a variety of patient populations. Prompt diagnosis and management of these lesions are essential to prevent patient morbidity and mortality. The purpose of this article is to summarize and review the evaluation, screening and early detection of premalignant lesions of the oral cavity and to highlight the role of the dental team in recognizing and treating patients with these conditions, that may progress to oral cancer. In addition, a review of a non-invasive detection technique that is curre

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Viglianisi, Gaia, Alessandro Polizzi, Cristina Grippaudo, Salvatore Cocuzza, Rosalia Leonardi, and Gaetano Isola. "Chemopreventive and Biological Strategies in the Management of Oral Potentially Malignant and Malignant Disorders." Bioengineering 11, no. 1 (2024): 65. http://dx.doi.org/10.3390/bioengineering11010065.

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Oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) represent a significant global health burden due to their potential for malignant transformation and the challenges associated with their diagnosis and treatment. Chemoprevention, an innovative approach aimed at halting or reversing the neoplastic process before full malignancy, has emerged as a promising avenue for mitigating the impact of OPMD and OSCC. The pivotal role of chemopreventive strategies is underscored by the need for effective interventions that go beyond traditional therapies. In this regard, ch

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Bugshan, Amr, and Imran Farooq. "Oral squamous cell carcinoma: metastasis, potentially associated malignant disorders, etiology and recent advancements in diagnosis." F1000Research 9 (April 2, 2020): 229. http://dx.doi.org/10.12688/f1000research.22941.1.

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Oral squamous cell carcinoma (OSCC) is a commonly occurring head and neck cancer. It has a high prevalence in certain parts of the world, and is associated with a high mortality rate. In this review, we describe metastasis related to OSCC, and disorders that could lead to OSCC with common etiological factors. In addition, a brief account of the diagnosis of OSCC and role of salivary biomarkers in its early detection has also been highlighted. Google Scholar and PubMed search engines were searched with keywords including “oral squamous cell carcinoma”, “OSCC”, “oral cancer”, “potentially malign

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Puspasari, Karlina, Togu Andrie Simon Pasaribu, Meircurius Dwi Condro Surboyo, Nurina Febriyanti Ayuningtyas, Arvind Babu Rajendra Santosh, and Diah Savitri Ernawati. "Oral field cancerization: Genetic profiling for a prevention strategy for oral potentially malignant disorders." Dental Journal 56, no. 3 (2023): 189–96. http://dx.doi.org/10.20473/j.djmkg.v56.i3.p189-196.

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Background: Oral cancer therapy, such as radiation or surgical treatment, has pernicious long-term effects that patients suffer throughout their life, the disability being considerable with delayed diagnosis. It is well known that many oral cancers develop from oral potentially malignant disorders (OPMDs). Patients diagnosed with OPMDs may have an increased risk of developing cancer anywhere in the oral cavity. Early detection and intervention could be essential prevention strategies to inhibit oral cancer progression. OPMDs may not immediately develop into carcinoma. However, this condition p

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Singh, Shruti, Jaya Singh, Fahad Mansoor Samadi, Shaleen Chandra, Roop Ganguly, and Shaista Suhail. "Evaluation of hematological parameters in oral cancer and oral pre-cancer." International Journal of Basic & Clinical Pharmacology 9, no. 7 (2020): 1090. http://dx.doi.org/10.18203/2319-2003.ijbcp20202947.

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Background: Oral squamous cell carcinoma (OSCC) is the most common public health issue in Indian population. Quite a large number of OSCC cases are preceded by potentially malignant disorders of oral cavity. The need for simple diagnostic marker for early diagnosis and thus better therapeutic outcome is imperative. The current study aims to evaluate hematological parameters such as hemoglobin, bleeding time, clotting time, total leucocyte count (TLC) and differential leucocyte count (DLC) in OSCC and oral potentially malignant disorder cases along with normal healthy controls.Methods: A total

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Anaya-Saavedra, Gabriela, Velia Ramírez-Amador, Itzel Castillejos-García, and Marcela Saeb-Lima. "Impact of early recognition of potentially malignant oral disorders on the prognosis in people living with HIV." International Journal of STD & AIDS 30, no. 7 (2019): 723–26. http://dx.doi.org/10.1177/0956462419838102.

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Despite the success of combination antiretroviral therapies, people living with HIV (PLWH) are at an increased risk of developing diverse malignancies, including oral cancer. We here present two cases of PLWH where the early diagnosis of potentially malignant disorders in the oral cavity impacted their treatment and survival, remaining free of disease after their complete elimination. These cases demonstrate the importance of oral examinations and tissue biopsies as a part of the close monitoring of PLWH.

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Sanjai, Dr Karpagaselvi, and Dr Lalita Jayaram Thambiah. "APPLICABILITY OF ORAL EPITHELIAL DYSPLASIA GRADING IN POTENTIALLY MALIGNANT DISORDERS OF ORAL CAVITY-AN INSTITUTIONAL REVIEW." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 128, no. 1 (2019): e40. http://dx.doi.org/10.1016/j.oooo.2019.02.077.

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Kaur, Ravneet, Sonal Grover, Manoj Jaiswal, and Nirmal Kurian. "Bibliometric Analysis of Top 100 Most Cited Articles on Potentially Malignant Disorders of the Oral Cavity." CHRISMED Journal of Health and Research 10, no. 4 (2023): 314–18. http://dx.doi.org/10.4103/cjhr.cjhr_70_23.

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Abstract Objectives: The objective is to study the characteristics of top 100 most cited articles on oral potentially malignant disorders of the oral cavity. Materials and Methods: The Web of Science database was used to retrieve the top most cited articles using keyword “potentially malignant disorders,” “premalignant lesions” and “premalignant conditions.” The data was searched to include journal name, publication year, authors, country of origin and type of study. These data were used to study the characteristics of top 100 most cited articles. Results: The top 100 articles had a combined c

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Mogre, Saie, Vidhi Makani, Swapnita Pradhan, et al. "Biomarker Potential of Vimentin in Oral Cancers." Life 12, no. 2 (2022): 150. http://dx.doi.org/10.3390/life12020150.

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Oral carcinogenesis is a multistep process. As much as 5% to 85% of oral tumors can develop from potentially malignant disorders (PMD). Although the oral cavity is accessible for visual examination, the ability of current clinical or histological methods to predict the lesions that can progress to malignancy is limited. Thus, developing biological markers that will serve as an adjunct to histodiagnosis has become essential. Our previous studies comprehensively demonstrated that aberrant vimentin expression in oral premalignant lesions correlates to the degree of malignancy. Likewise, overwhelm

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Yap, Tami, Neha Pruthi, Christine Seers, Simone Belobrov, Michael McCullough, and Antonio Celentano. "Extracellular Vesicles in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review." International Journal of Molecular Sciences 21, no. 4 (2020): 1197. http://dx.doi.org/10.3390/ijms21041197.

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Extracellular vesicles (EVs) are secreted from most cell types and utilized in a complex network of near and distant cell-to-cell communication. Insight into this complex nanoscopic interaction in the development, progression and treatment of oral squamous cell carcinoma (OSCC) and precancerous oral mucosal disorders, termed oral potentially malignant disorders (OPMDs), remains of interest. In this review, we comprehensively present the current state of knowledge of EVs in OSCC and OPMDs. A systematic literature search strategy was developed and updated to December 17, 2019. Fifty-five article

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Chandra, Shruti, Nitin Nigam, SivaPrasad Reddy Enja, and Neelakshi Pandey. "Effect of curcumin in reducing burning sensation in potentially malignant disorders of oral cavity." Journal of Indian Academy of Oral Medicine and Radiology 29, no. 1 (2017): 7. http://dx.doi.org/10.4103/jiaomr.jiaomr_37_16.

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Balasundaram, I., K. F. B. Payne, I. Al-Hadad, M. Alibhai, S. Thomas, and R. Bhandari. "Is there any benefit in surgery for potentially malignant disorders of the oral cavity?" Journal of Oral Pathology & Medicine 43, no. 4 (2013): 239–44. http://dx.doi.org/10.1111/jop.12088.

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Piyarathne, N. S., S. N. Liyanage, R. M. S. G. K. Rasnayaka, et al. "A comprehensive dataset of annotated oral cavity images for diagnosis of oral cancer and oral potentially malignant disorders." Oral Oncology 156 (September 2024): 106946. http://dx.doi.org/10.1016/j.oraloncology.2024.106946.

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Jatti, Deepa, Yashoda DeviBhoomareddy Kantraj, and Rakesh Nagaraju. "Role of dermatoglyphics in malignant and potentially malignant disorders of the oral cavity: A cross-sectional study." Journal of Indian Academy of Oral Medicine and Radiology 26, no. 4 (2014): 379. http://dx.doi.org/10.4103/0972-1363.155674.

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R., Kanimozhi, Saraswathi Gopal K., and Mahesh Kumar P. "EVALUATION OF CYTOGENIC DAMAGE IN ORAL EXFOLIATED BUCCAL CELLS OF TOBACCO USERS AND PATIENTS WITH POTENTIALLY MALIGNANT DISORDERS USING MICRONUCLEUS ASSAY - A PROSPECTIVE STUDY." International Journal of Advanced Research 11, no. 05 (2023): 733–42. http://dx.doi.org/10.21474/ijar01/16926.

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Background: Cytogenic methods acts with complex type mutations, known as structural mutations (aberrations)and a special type of chromosomal damage, known as micronucleus. So, micronucleus (MN) assay has been used as a biomarker of genetic damage in buccal mucosa cells. Aim and Objectives: To evaluate micronucleus in the exfoliated cells of buccal mucosa of individuals with potentially malignant disorders and different tobacco related habits and in control group. To observe the incidence of micronucleus count based on duration, frequency and type of tobacco usage and also auto immune condition

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Choudhary, Priyanka, Jyoti Kasana, Bhupender Bhati, Vidyadevi Chandavarkar, Deepak Bhargava, and Mithilesh N. Mishra. "Cytomorphological and Cytomorphometric Analysis of Oral Squames in Smokers Using Computer Aided Image Analysis System." Journal of Pharmacy and Bioallied Sciences 16, Suppl 4 (2024): S3524—S3527. https://doi.org/10.4103/jpbs.jpbs_1061_24.

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ABSTRACT Objective: This study aimed to assess the impact of smoking on oral mucosa and evaluate the role of cytomorphometry in diagnosing and prognosing potentially malignant disorders. Study Design: The study included 75 patients both smokers and non-smokers with and without smoking-related lesions. We measured cellular diameter (CD), nuclear diameter (ND), cellular area (CA) and nuclear area (NA) of buccal mucosa squames using PAP stain and image analysis software (Pixel Pro by Labo Med). Results: Smokers, regardless of lesion presence showed increased ND, decreased CD, increased NA and dec

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Modak, Baishakhi, Monica C. Solomon, Shaswata Karmakar, and Shreyasi Polley. "Gene therapy as a treatment of oral cancer: An insight." Journal of Oral and Maxillofacial Pathology 27, no. 2 (2023): 390–95. http://dx.doi.org/10.4103/jomfp.jomfp_46_23.

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Oral cancer or oral squamous cell carcinoma comprises more than three-fourth of all the malignant neoplasms of the oral cavity. Worldwide, it is the 18th most common malignancy. The patients suffering from cancer usually remains immune to the standard therapies such as surgical resection of tumours, radiotherapy and chemotherapy; however, there can be probabilities of chronic and acute toxicities and secondary malignancies as well. Recently, gene therapy has been introduced in the arena of biomedicine to improve the treatment modality for oral malignant and potentially malignant disorders. It

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Kujan, Omar, Bede van Schaijik, and Camile S. Farah. "Immune Checkpoint Inhibitors in Oral Cavity Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review." Cancers 12, no. 7 (2020): 1937. http://dx.doi.org/10.3390/cancers12071937.

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Cancers of the oral cavity cause significant cancer-related death worldwide. While survival rates have improved in recent years, new methods of treatment are being investigated to limit disease progression and to improve outcomes, particularly in oral cavity squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD). The emerging treatment modality of immunotherapy targets immune checkpoint molecules including PD-1 and its ligand PD-L1, CTLA-4, LAG-3, and TIM-3 to enhance the host immune response against tumours, and to limit the growth and progression of cancer cells. In t

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Chaudhary, Minal, Madhuri Gawande, and Preethi Sharma. "Evaluation of Prevalence of Bacteria Helicobacter pylori in Potentially Malignant Disorders and Oral Squamous Cell Carcinoma." World Journal of Dentistry 6, no. 2 (2015): 82–86. http://dx.doi.org/10.5005/jp-journals-10015-1319.

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ABSTRACT Cancer is a complex disease that is variable in its presentation, development and outcome. The same heterogeneity and variability exist at the cellular and molecular level. Cancer is a multistep process during which cells undergo intense metabolic and behavioral changes, leading them to proliferate in an extreme and early way to escape supervision by the immune system and ultimately invades distant tissues to form metastases. Globally, almost 20% of cancers are related to infectious agents. Several viruses with oncogenic potential stimulate cell proliferation leading to cancer in anim

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Gupta, Kanupriya, Jatin Gupta, and Rahul Agarwal. "Comparison of different stains in exfoliated oral mucosal cell micronucleus of potentially malignant disorders of oral cavity." Journal of Cancer Research and Therapeutics 15, no. 3 (2019): 615. http://dx.doi.org/10.4103/jcrt.jcrt_1326_16.

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Talwar, Vivek, Pragya Singh, Nirza Mukhia, et al. "AI-Assisted Screening of Oral Potentially Malignant Disorders Using Smartphone-Based Photographic Images." Cancers 15, no. 16 (2023): 4120. http://dx.doi.org/10.3390/cancers15164120.

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The prevalence of oral potentially malignant disorders (OPMDs) and oral cancer is surging in low- and middle-income countries. A lack of resources for population screening in remote locations delays the detection of these lesions in the early stages and contributes to higher mortality and a poor quality of life. Digital imaging and artificial intelligence (AI) are promising tools for cancer screening. This study aimed to evaluate the utility of AI-based techniques for detecting OPMDs in the Indian population using photographic images of oral cavities captured using a smartphone. A dataset comp

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Vikey, Ashok, and Astha Pusame. "Evaluation of Candidal Species in Oral Submucous Fibrosis and Oral Lichen Planus: A Microbiological Study." Microbiology Research Journal International 34, no. 5 (2024): 29–37. http://dx.doi.org/10.9734/mrji/2024/v34i51444.

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Background: Candida is opportunistic microorganisms in oral cavity, causes oral candidiasis. The presence of candida and subspecies in oral premalignant lesions may intensify the infection and transform pre malignant lesions into cancer. Objective: To isolate various types of candida species, among Oral submucous fibrosis (OSMF) and Oral lichen Planus (OLP) patients. Methodology: Total 60 individuals included and grouped as; OSMF (n=20) group A, Lichen Planus (n=10); group B and Controls (n=30) group C. Results: The higher candida carriage revealed in OSMF+ OLP groups (23.3%) as compared to co

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Moisa, Mihai Radu, Elena Claudia Coculescu, Marina Imre, Alexandra Ripszky, Bogdan-Ioan Coculescu, and Silviu Mirel Pituru. "PI3K/AKT/MTOR SIGNALING PATHWAY – A KEY PLAYER IN THE MOLECULAR LANDSCAPE OF MALIGNANT TRANSFORMATION OF ORAL LESIONS." Romanian Journal of Oral Rehabilitation 16, no. 2 (2024): 214–24. https://doi.org/10.62610/rjor.2024.2.16.21.

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Aberrant PI3K/AKT/mTOR/ pathway have been considered one of the starting points of various types of human cancer, including the oral squamous cell carcinoma (OSCC). The important role played by this signaling pathway in oncogenesis and cancer evolution, oriented the researchers’ attention toward studies of AKT and the PI3K/AKT/mTOR axis in the context of malignant transformation of oral precancerous lesions. Consequently, this article’s aim is an update of the possible key role played by the PI3K /AKT/mTOR axis on the oral lesions’ malignant transformation stage. Oral potentially malignant dis

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