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1

Scorsone, Emmanuel, Nouha Gattout, Lionel Rousseau, and Gaelle Lissorgues. "Porous diamond pouch cell supercapacitors." Diamond and Related Materials 76 (June 2017): 31–37. http://dx.doi.org/10.1016/j.diamond.2017.04.004.

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2

Bridgewater, Grace, Matthew J. Capener, James Brandon, Michael J. Lain, Mark Copley, and Emma Kendrick. "A Comparison of Lithium-Ion Cell Performance across Three Different Cell Formats." Batteries 7, no. 2 (2021): 38. http://dx.doi.org/10.3390/batteries7020038.

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To investigate the influence of cell formats during a cell development programme, lithium-ion cells have been prepared in three different formats. Coin cells, single layer pouch cells, and stacked pouch cells gave a range of scales of almost three orders of magnitude. The cells used the same electrode coatings, electrolyte and separator. The performance of the different formats was compared in long term cycling tests and in measurements of resistance and discharge capacities at different rates. Some test results were common to all three formats. However, the stacked pouch cells had higher discharge capacities at higher rates. During cycling tests, there were indications of differences in the predominant degradation mechanism between the stacked cells and the other two cell formats. The stacked cells showed faster resistance increases, whereas the coin cells showed faster capacity loss. The difference in degradation mechanism can be linked to the different thermal and mechanical environments in the three cell formats. The correlation in the electrochemical performance between coin cells, single layer pouch cells, and stacked pouch cells shows that developments within a single cell format are likely to lead to improvements across all cell formats.
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3

Cao, S., P. Deepak, and M. Colonna. "DOP41 Mucosal single-cell profiling of Crohn's-like disease of the pouch reveal unique pathogenesis and therapeutic targets." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i144—i146. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0081.

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Abstract Background After restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC), a subset of patients develop Crohn’s-like disease of the pouch (CDP), a chronic inflammatory condition that affects both the pouch body and extra-pouch organs including the pre-pouch ileum. The cellular and molecular identities of CDP are unknown, and its diagnosis and treatment remain challenging. To define the pathophysiology of CDP, we examined mucosal cells from patients after IPAA with and without CDP using single cell analyses. Methods Endoscopic samples from the pouch body and pre-pouch ileum of 50 patients with an IPAA were collected for single-cell RNA sequencing (scRNA-seq) or mass cytometry (or CyTOF). We analyzed immune and non-immune cells from both pouch body and pre-pouch ileum of patients with normal pouch/ileum and CDP using scRNA-seq. CyTOF was performed on mucosal immune cells from independent cohorts of patients with normal pouch/ileum, CDP, and pouchitis. Mucosal samples from patients with familial adenomatous polyposis (FAP) after colectomy and pouch formation were also analyzed by CyTOF. ScRNA-seq and CyTOF findings were independently validated using immunohistochemistry. Results We revealed distinct cell clusters in normal pouch body versus normal pre-pouch ileum in UC patients. Colitogenic immune cells expanded in normal UC pouch body compared to normal FAP pouch body. Compared to normal pouch/ileum, CDP pouch/ileum exhibited expanded TCR clonotypes, elevated Th17 signaling, and diminished T cell exhaustion markers. Elevated plasma cells, inflammatory fibroblasts and monocytes were noted in CDP pouch/ileum (Figure 1). CDP also harbored elevated Th17-inducing cytokines such as IL23, IL1B, and IL6 produced by myeloid cells. ScRNA-seq and CyTOF identified increased CD14+TREM1+ pathogenic monocytes in both pouch body and pre-pouch ileum of CDP. Ligand-receptor analysis further revealed a stromal – myeloid – lymphocyte circuit in CDP. Integrated analysis showed that upregulated immune mediators in CDP tissues were similar to those in CD and pouchitis, but not UC. In addition, the pouch body and pre-pouch ileum of CDP exhibited prominent activation of the unfolded protein response (UPR) across all major immune and non-immune cell compartments (Figure 2), which was not present in UC, CD or pouchitis based on reanalysis of published databases. Conclusion CDP demonstrates altered immune and non-immune cell populations/states in the pouch body and pre-pouch ileum. CDP represents a distinct entity of inflammatory bowel disease with extensive UPR activation, a unique feature that may serve as novel diagnostic markers and therapeutic targets using ER stress-alleviating agents including chemical chaperones.
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Cao, Siyan, Nicholas Davidson, Matthew Ciorba, Parakkal Deepak, and Marco Colonna. "MUCOSAL SINGLE-CELL PROFILING OF CROHN’S-LIKE DISEASE OF THE POUCH REVEALS COMMON PATHOGENICS AND THERAPEUTIC TARGETS." Inflammatory Bowel Diseases 30, Supplement_1 (2024): S68—S69. http://dx.doi.org/10.1093/ibd/izae020.148.

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Abstract BACKGROUND & AIMS After restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC), a subset of patients develop Crohn’s-like disease of the pouch (CDP), an inflammatory condition that affects both the ileoanal pouch and extra-pouch organs including pre-pouch ileum. The cellular and molecular identities of CDP are unknown, and its diagnosis and treatment remain challenging. To define the pathophysiology of CDP, we examined mucosal cells from patients with and without CDP using single cell analyses. METHODS Endoscopic samples from the pouch and pre-pouch ileum of 50 patients with an IPAA were collected for single-cell RNA sequencing (scRNA-seq) or mass cytometry (or CyTOF). We analyzed immune and non-immune cells from pouch and ileal tissues of patients with normal pouch/ileum and CDP (n = 5 or 6) using scRNA-seq. CyTOF was performed on mucosal immune cells from independent cohorts of patients with normal pouch/ileum, CDP, and pouchitis (n = 9 or 10). Mucosal samples from patients with familial adenomatous polyposis (FAP) after pouch formation were also analyzed by CyTOF. Some scRNA-seq and CyTOF findings were independently validated using immunohistochemistry (n = 6 or 8). RESULTS We revealed distinct immune and non-immune cell clusters in normal pouch and pre-pouch ileum. Colitogenic immune cells expanded in normal UC pouch compared to normal FAP pouch. Compared to normal pouch/pre-pouch ileum, CDP tissues exhibited expanded TCR clonotypes, elevated Th17 signaling, and diminished T cell exhaustion markers. Elevated frequencies of plasma cells, inflammatory fibroblasts and monocytes were noted in CDP pouch and ileum (Fig 1; only pouch data were shown). CDP also harbored elevated Th17-inducing cytokines such as IL23, IL1B, and IL6 produced by myeloid cells. ScRNA-seq and CyTOF identified increased CD14+TREM1+ pathogenic monocytes in both pouch and pre-pouch ileum of CDP. Ligand-receptor interactions further uncovered an essential role of proinflammatory myeloid cells in the pathogenesis of CDP. In addition, pouch and pre-pouch ileum of CDP showed prominent activation of the unfolded protein response (UPR) across all major cell compartments (Fig 2), which was not present in UC, CD or pouchitis based on integrated analysis of published databases. CONCLUSIONS CDP demonstrates altered immune and non-immune cell populations/states in the pouch and pre-pouch ileum. CDP represents a distinct entity of inflammatory bowel disease with extensive UPR activation, a unique feature that may serve as novel diagnostic markers and therapeutic targets using ER stress-alleviating agents including chemical chaperones. Fig 1 CDP reshapes immune and non-immune landscapes in pouch and pre-pouch ileum. (A) UMAP visualization of all cells from the pouch and ileum of CLDP and normal controls. (B) Diversity of epithelial cells, stromal cells, myeloid cells, T cells, innate lymphoid cells (ILCs), B cells and plasma cells in CLDP vs. normal controls in the pouch estimated by scRNA-seq (n = 5 or 6). *p<0.01. Fig 2 Extensive UPR activation in CDP tissues. (A) UPR gene expression in major cell compartments in CDP and normal controls, highlighted genes including CALR, XBP1, and SERP1 were upregulated in all 5 cell compartments. (B) ER stress/UPR pathways are enriched in CDP. (C) IHC of UPR proteins XBP1 and HSPA5/BiP.
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5

Crowther, Owen. "Rechargeable Lithium Metal Pouch Cell Development." ECS Meeting Abstracts MA2021-01, no. 1 (2021): 20. http://dx.doi.org/10.1149/ma2021-01120mtgabs.

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6

Willow, Ashley, Marcin Orzech, Sajad Kiani, et al. "Design and Validation of Anode-Free Sodium-Ion Pouch Cells Employing Prussian White Cathodes." Batteries 11, no. 3 (2025): 97. https://doi.org/10.3390/batteries11030097.

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This study investigated the impact of pouch cell design on energy density, both volumetric and gravimetric, through the development of accurate 3D models of small-format (<5 Ah) pouch cells. Various configurations were analysed, considering material properties and extrapolating expected electrochemical performance from studies on Prussian white cathodes in coin and pouch cells. This approach allowed for a rapid assessment of several performance-influencing factors, including the number of layers in the pouch cell, cathode thickness, active material percentage, and electrolyte volume. The highest calculated energy density of small-format pouch cells was shown to be 282 Wh kg−1 and 454 Wh L−1, achieved in a 3 Ah, 20-layer pouch cell. The calculations were validated using sodium-ion anode-free pouch cells utilising a Prussian white cathode in single- and few-layer format pouch cells (<0.1 Ah) cycled under a low external pressure (~200 kPa).
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7

Li, Bin. "Unlocking Failure Mechanisms and Improvement of Practical Li-S Pouch Cells through in Operando Pressure Study." ECS Meeting Abstracts MA2022-01, no. 1 (2022): 109. http://dx.doi.org/10.1149/ma2022-011109mtgabs.

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Lithium-sulfur (Li-S) batteries have been considered a promising candidate for next-generation high-energy density storage technology due to their low cost and high theoretical capacity. However, since 2017, more and more attentions have been paid to the gap of lab cell characterization (coin cell) and prototype cell (pouch cell) development since misinterpretations and false expectations are frequently reported: material property impacts are often over-interpreted, while parameters with indirect impact (e.g., electrode and separator porosity, tortuosity, and pressure on cell stack) are neglected. In order to accelerate Li-S battery commercialization, the rapid transfer of material-related concept discovered in coin cells to a pouch cell level is essential, as some problems ignored or deemed minimal at the smaller level could have a greater effect on the performance of the larger pouch cell. The issues existing in practical pouch cell should be discovered, which would shed light on further battery materials development, or inspire the novel approaches to identify cell failure and improve cell performances at the pouch cell level. Considering the gap between practical pouch cells and coin cells, in addition to the noticeable difference in electrode size (e.g., the electrode size of practical pouch cell is usually >100 times of that of coin cell), a much higher stack pressure (> 1Mpa) is usually applied inside the coin cell. It was taken for granted that stack pressure was playing a critical role, leading to inconsistent performance between pouch cells and coin cells. Furthermore, with increasing size of the cells (especially for multi-layer pouch cells), the electrolyte wettability needs to be taken seriously. Otherwise, the sulfur utilization would be largely reduced as ionic conduction pathways was significantly affected. Herein, we rationally designed two kinds of cathode: Non-calendared sulfur electrode (NCSE) and Calendared sulfur electrode (CSE). The former’s porosity (ε) and tortuosity (τ) were proven to change with stack pressures while the latter’s do not change by simulations based on micro-XCT results with in-situ pressure applied. These two sulfur cathodes provide preconditions to distinguish the effects of stack pressure and porosity/tortuosity on Li-S pouch cell performances. For the first time, through in-situ monitoring of pressure applied onto Li-S pouch cells, the failure mechanisms of Li-S pouch cells were deeply understood, and the approaches to improve Li-S pouch cell performances were identified. It is found that highly porous structures of cathodes/separators and slow electrolyte diffusion through cathodes/separators can both lead to poor initial wetting. Additionally, Li-metal anode dominates the thickness variation of the whole pouch cell, which is verified by in situ measured pressure variation. Consequently, a real-time approach that combined normalized pressure with dP/dV analysis is proposed and validated to diagnose the morphology evolution of Li-metal anode. Moreover, applied pressure and porosity/tortuosity ratio of the cathode are both identified as independent factors that influence anode performance. In addition to stabilizing anodes, high pressure is proven to improve the cathode connectivity and avoid cathode cracking over cycling, which improves the possibility of developing cathodes with high sulfur mass loading. This work provides insights into Li-S pouch cell design (e.g., cathode and separator) and highlights pathways to improve cell capacity and cycling performance with applied and monitored pressure. Figure 1
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8

Shen, Bo, Wendy Liu, Feza H. Remzi, et al. "Enterochromaffin Cell Hyperplasia in Irritable Pouch Syndrome." American Journal of Gastroenterology 103, no. 9 (2008): 2293–300. http://dx.doi.org/10.1111/j.1572-0241.2008.01990.x.

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9

Condurache, Dorina Gabriela, Jonathan P. Segal, Ailsa L. Hart, and Anthony Antoniou. "Squamous cell carcinoma at the site of ileo-anal pouch in Crohn’s disease." BMJ Case Reports 14, no. 2 (2021): e237438. http://dx.doi.org/10.1136/bcr-2020-237438.

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Few cases of pouch-related cancers have been reported in inflammatory bowel disease, and squamous cell carcinoma (SCC) is very rare. We have reviewed the published literature searching the online databases PubMed and Medline. Since 1979, there have been eight cases of SCC developing after restorative proctocolectomy in ulcerative colitis. To date, there have been no reported cases of SCC of the ileo-anal pouch in Crohn’s disease. We present the case of a 59-year-old woman who underwent colectomy with ileal pouch-anal anastomosis for Crohn’s disease during the 1990s. The patient was noted to be anaemic and was experiencing significant weight loss with poor pouch function in 2019. Endoscopy with histology and radiological investigation revealed the presence of SCC of the pouch. This was subsequently treated with surgical therapy and chemoradiotherapy.
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10

Pellino, Gianluca, Christos Kontovounisios, Diana Tait, John Nicholls, and Paris P. Tekkis. "Squamous Cell Carcinoma of the Anal Transitional Zone after Ileal Pouch Surgery for Ulcerative Colitis: Systematic Review and Treatment Perspectives." Case Reports in Oncology 10, no. 1 (2017): 112–22. http://dx.doi.org/10.1159/000455898.

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Background: Few cases of pouch-related cancers have been reported in ulcerative colitis (UC), and squamous cell carcinoma (SCC) is very rare. Method: A systematic review of the literature was performed to identify all unequivocal cases of pouch-related SCC in UC patients. Results: Eight cases of SCC developing after ileal pouch-anal anastomosis (IPAA) have been observed since 1978. Two arose from the pouch mucosa and 6 from below. The pooled cumulative incidence of SCC is below 0.06% after IPAA. Many patients had neoplasia on the preoperative specimen, but squamous metaplasia of the pouch or anorectal mucosa may have an important role in SCC. These patients are rarely offered chemoradiation therapy and the outcome is poor. Selected patients with SCC located close to the pouch outlet can be treated with chemoradiation prior to consideration of surgery and salvage their pouch. A chemoradiation regimen is suggested to avoid pouch excision in these patients. Conclusions: SCC is rare after pouch surgery but associated with extremely poor survival. Very low SCC can be managed with chemoradiation treatment, preserving the pouch and avoiding surgery, even in older patients. The role of pouch metaplasia, surveillance frequency, and treatment modalities after IPAA need further studying.
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11

Garayt, Matthew D. L., Michel B. Johnson, Lauren Laidlaw, et al. "A Guide to Making Highly Reproducible Li-Ion Single-Layer Pouch Cells for Academic Researchers." Journal of The Electrochemical Society 170, no. 8 (2023): 080516. http://dx.doi.org/10.1149/1945-7111/aceffc.

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With the growing number of academic researchers focused on lithium-ion batteries, the cell format of choice is often overlooked. Coin cells that utilize either a lithium metal or greatly oversized graphite negative electrode are common but can provide unrealistic testing results when compared to commercial pouch-type cells. Instead, single-layer pouch cells provide a more similar format to those used in industry while not requiring large amounts of active material. Moreover, their assembly process allows for better positive/negative electrode alignment, allowing for assembly of single-layer pouch cells without negative electrode overhang. This work presents a comparison between coin, single-layer pouch, and stacked pouch cells, and shows that single-layer pouch cells without overhang perform best. As well, an Ultra-High Precision Coulometry experiment is performed to show that excess negative or positive electrode coating is detrimental to cell performance. Finally, a guide to assembling reproducible single-layer pouch cells without overhang is presented.
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12

Patil, Mahesh, Satyam Panchal, Namwon Kim, and Moo-Yeon Lee. "Cooling Performance Characteristics of 20 Ah Lithium-Ion Pouch Cell with Cold Plates along Both Surfaces." Energies 11, no. 10 (2018): 2550. http://dx.doi.org/10.3390/en11102550.

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Temperature control of the lithium-ion pouch cells is crucial for smooth operation, longevity and enhanced safety in the battery-operated electric vehicles. Investigating the thermal behavior of lithium-ion pouch cells and optimizing the cooling performance are required to accomplish better performance, long life, and enhanced safety. In the present study, the cooling performance characteristics of 20 Ah lithium-ion pouch cell with cold plates along both surfaces are investigated by varying the inlet coolant mass flow rates and the inlet coolant temperatures. The inlet coolant mass flow rate is varied from 0.000833 kg/s to 0.003333 kg/s, and the inlet coolant temperature is varied from 5 °C to 35 °C. In addition, the effects of the cold plate geometry parameter on cooling performance of 20 Ah lithium-ion pouch cell are studied by varying the number of the channels from 4 to 10. The maximum temperature and difference between the maximum and the minimum temperatures are considered as important criteria for cooling performance evaluation of the 20 Ah lithium-ion pouch cell with cold plates along both surfaces. The cooling energy efficiency parameter (β) and the pressure drop for 20 Ah lithium-ion pouch cell with cold plates along both surfaces are also reported. The study shows that enhanced cooling energy efficiency is accompanied with low inlet coolant temperature, low inlet coolant mass flow rate, and a high number of the cooling channels. As a result, the temperature distribution, the pressure drop, and the cooling energy efficiency parameter (β) of the 20 Ah lithium-ion pouch cell with cold plates along both surfaces are provided, and could be applied for optimizing the cooling performances of the thermal management system for lithium-ion batteries in electric vehicles.
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13

Patil, Mahesh Suresh, Satyam Panchal, Namwon Kim, and Moo-Yeon Lee. "Cooling Performance Characteristics of 20 Ah Lithium-Ion Pouch Cell with Cold Plates along Both Surfaces." energies 11, no. 10 (2018): 2550. https://doi.org/10.3390/en11102550.

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Temperature control of the lithium-ion pouch cells is crucial for smooth operation, longevity and enhanced safety in the battery-operated electric vehicles. Investigating the thermal behavior of lithium-ion pouch cells and optimizing the cooling performance are required to accomplish better performance, long life, and enhanced safety. In the present study, the cooling performance characteristics of 20 Ah lithium-ion pouch cell with cold plates along both surfaces are investigated by varying the inlet coolant mass flow rates and the inlet coolant temperatures. The inlet coolant mass flow rate is varied from 0.000833 kg/s to 0.003333 kg/s, and the inlet coolant temperature is varied from 5 °C to 35 °C. In addition, the effects of the cold plate geometry parameter on cooling performance of 20 Ah lithium-ion pouch cell are studied by varying the number of the channels from 4 to 10. The maximum temperature and difference between the maximum and the minimum temperatures are considered as important criteria for cooling performance evaluation of the 20 Ah lithium-ion pouch cell with cold plates along both surfaces. The cooling energy efficiency parameter (β) and the pressure drop for 20 Ah lithium-ion pouch cell with cold plates along both surfaces are also reported. The study shows that enhanced cooling energy efficiency is accompanied with low inlet coolant temperature, low inlet coolant mass flow rate, and a high number of the cooling channels. As a result, the temperature distribution, the pressure drop, and the cooling energy efficiency parameter (β) of the 20 Ah lithium-ion pouch cell with cold plates along both surfaces are provided, and could be applied for optimizing the cooling performances of the thermal management system for lithium-ion batteries in electric vehicles.
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14

Bonney, William W., Robert A. Robinson, Richard A. Anderson-Sprecher, and James W. Osborne. "Crypt Cell Thymidine Incorporation in Ileal Urinary Pouch." Scandinavian Journal of Urology and Nephrology 28, no. 2 (1994): 147–51. http://dx.doi.org/10.3109/00365599409180491.

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Devie, Arnaud, Matthieu Dubarry, Hung-Ping Wu, Tsung-Han Wu, and Bor Yann Liaw. "Overcharge Study in Li4Ti5O12Based Lithium-Ion Pouch Cell." Journal of The Electrochemical Society 163, no. 13 (2016): A2611—A2617. http://dx.doi.org/10.1149/2.0491613jes.

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16

Macdonald, E., C. Gee, K. Kerr, A. Denison, R. Keenan, and N. Binnie. "Squamous cell carcinoma of an ileo-anal pouch." Colorectal Disease 12, no. 9 (2009): 945–46. http://dx.doi.org/10.1111/j.1463-1318.2009.02124.x.

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17

Honggowiranto, Wagiyo, Evvy Kartini, and Agus Sudjatno. "Study Performance of LiFePO4/Graphite Cylindrical Pouch Cell." IOP Conference Series: Materials Science and Engineering 924 (October 14, 2020): 012036. http://dx.doi.org/10.1088/1757-899x/924/1/012036.

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18

Devie, Arnaud, Matthieu Dubarry, and Bor Yann Liaw. "Overcharge Study in Li4Ti5O12Based Lithium-Ion Pouch Cell." Journal of The Electrochemical Society 162, no. 6 (2015): A1033—A1040. http://dx.doi.org/10.1149/2.0941506jes.

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19

NOGUEIRA, Thiago De Bortoli, Ricardo ARTIGIANI NETO, Benedito HERANI FILHO, and Jaques WAISBERG. "H. PYLORI INFECTION, ENDOSCOPIC, HISTOLOGICAL ASPECTS AND CELL PROLIFERATION IN THE GASTRIC MUCOSA OF PATIENTS SUBMITTED TO ROUX-EN-Y GASTRIC BYPASS WITH CONTENTION RING: a cross sectional endoscopic and immunohistochemical study." Arquivos de Gastroenterologia 53, no. 1 (2016): 55–60. http://dx.doi.org/10.1590/s0004-28032016000100011.

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ABSTRACT Background Morbid obesity treatment through vertical gastroplasty Roux-en-Y gastric bypass initially used a contention ring. However, this technique may create conditions to the development of potentially malign alterations in the gastric mucosa. Although effective and previously performed in large scale, this technique needs to be better evaluated in long-term studies regarding alterations caused in the gastric mucosa. Objective To analyze the preoperative and postoperative endoscopic, histological and cell proliferation findings in the gastric antrum and body mucosa of patients submitted to the Roux-en-Y gastric bypass with a contention ring. Methods We retrospectively evaluated all patients submitted to Roux-en-Y gastric bypass with a contention ring with more than 60 months of postoperative follow-up. We compared the preoperative (gastric antrum and body) and postoperative (gastric pouch) gastric mucosa endoscopic findings, cell proliferation index and H. pylori prevalence. We evaluated cell proliferation through Ki-67 antibody immunohistochemical expression. Results In the study period, 33 patients were operated with the Roux-en-Y gastric bypass using a contention ring. We found a chronic gastritis rate of 69.7% in the preoperative period (gastric antrum and body) and 84.8% in the postoperative (gastric pouch). H. pylori was present in 18.2% of patients in the preoperative period (gastric antrum and body) and in 57.5% in the postoperative (gastric pouch). Preoperative cell proliferation index was 18.1% in the gastric antrum and 16.2% in the gastric body, and 23.8% in the postoperative gastric pouch. The postoperative cell proliferation index in the gastric pouch was significantly higher (P=0.001) than in the preoperative gastric antrum and body. Higher cell proliferation index and chronic gastritis intensity were significantly associated to H. pylori presence (P=0.001 and P=0.02, respectively). Conclusion After Roux-en-Y gastric bypass with contention ring, there was a higher chronic gastritis incidence and higher cell proliferation index in the gastric pouch than in the preoperative gastric antrum and body. Mucosa inflammation intensity and cell proliferation index in the postoperative gastric pouch were associated to H. pylori presence and were higher than those found in the preoperative gastric antrum and body mucosa.
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Robert, Brian Joseph, Andre Lee, and Tyler Nathaniel Johnson. "Pouch Cell Case Laminate with Integrated Thermal Management Topologies." ECS Meeting Abstracts MA2024-01, no. 4 (2024): 651. http://dx.doi.org/10.1149/ma2024-014651mtgabs.

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With increased adoption of pouch-type battery cells in electrified vehicles there are evolving challenges for cell-to-array battery design. Trends of higher capacity and energy density as well as demands for reduced cost inspire integration opportunities of traditionally discrete functional components. Focusing on how battery cell active materials are packaged, specifically the polymer/aluminum laminate case, the formation of thermal transfer features at the pouch case surface would increase heat transfer efficiency and simplify the battery system by reducing components, weight, and volume. Designed topologies, from localized pin fins and straight channels to complex flow fields (Table 1), have been demonstrated at the pouch case laminate enabling a new design space at the cell level. This presentation will explore prototype designs, fabrication methods, and improvement areas for this technology. Table 1 - Extrusion roller press designs and demonstrated prototypes for variable spaced channel arrays, pin fin topologies, and flow field patterns Figure 1
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Garayt, Matthew D. L., Michel B. Johnson, Lauren Laidlaw, et al. "How to Make a Single-Layer Pouch Cell That Matches the Performance of a Commercial Li-Ion Cell." ECS Meeting Abstracts MA2023-02, no. 2 (2023): 434. http://dx.doi.org/10.1149/ma2023-022434mtgabs.

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As lithium-ion batteries (LIBs) have exploded in popularity due to the consumer electronics and electric vehicle industries, many resources are poured into research. While the simplest cell format requiring the least amount of active material to make in a research laboratory to study various aspects of the cell is usually the coin cell, it is far from the most representative of commercial LIBs. Oftentimes, coin cells are made with a large negative electrode overhang to reduce the risk from positive/negative electrode misalignment, but the overhang region can cause Li+ to become effectively trapped at higher C-rates1. While this is a necessary trade-off in today’s commercial LIB manufacturing, the overhang area is normally a much smaller fraction of the total negative electrode area in a commercial cell than in a laboratory coin cell, which can lead to discrepancies in cycle testing. Moreover, during assembly of commercial stacked or wound cells, there is always a region in which one side of a double-sided coating, typically the negative, is not needed and thus a single-sided electrode should be used. However, not all manufacturers eliminate the outward-facing second side and elect to simply use double-sided coatings throughout. Therefore, studying the effects of excess electrode in single-layer pouch cells will be explored in this presentation. In this presentation, cells made in various formats (coin and stacked pouch) will be compared to single-layer pouch cells made with and without negative electrode overhang. Single-layer pouch cells are the easiest format for assembling full cells without overhang because they are neither too small nor too big for positive/negative electrode alignment to be difficult. Moreover, single-layer pouch cells made with double-sided coatings (without overhang) and cycled using Ultra-High Precision Coulometry (UHPC) will be shown to have poor cycling. This is for two reasons: 1) for a double-sided negative, the outward-facing coating of the electrode can trap Li+ just like the overhang on the inward-facing coating; and 2) the outward-facing positive can be deintercalated and provide more capacity than desired2, possibly even surpassing the negative/positive areal capacity ratio. Single-layer pouch cells with no overhang are shown in Figure 1a to outperform all other cell formats tested, retaining 90% of their original capacity after 500 cycles at C/3 and 40 °C, and have the lowest difference in capacity between typical C/3 and C/20 checkup cycles as shown in Figure 1b. The stacked pouch cells in Figure 1 are composed of 3 positive and 4 negative electrodes that are all double-sided, meaning there are two outward-facing negative electrode coatings that can trap Li+, possibly resulting in the much poorer capacity fade to 80% after 500 cycles illustrated in Figure 1a. Thus, single-layer pouch cells without overhang give the most realistic cycling results for the tested electrode materials. Figure 1. C/3 cycling of full cells of various formats denoted in the legend. Plotted in (a) is the normalized discharge capacity and (b) is the difference in areal discharge capacity between the C/20 checkup cycle and preceding C/3 cycle. REFERENCES Gyenes, B., Stevens, D.A., Chevrier, V.L., and Dahn, J.R. (2015). Understanding Anomalous Behavior in Coulombic Efficiency Measurements on Li-Ion Batteries. J Electrochem Soc 162, A278–A283. 10.1149/2.0191503jes. Smith, A., Stüble, P., Leuthner, L., Hofmann, A., Jeschull, F., and Mereacre, L. (2023). Potential and Limitations of Research Battery Cell Types for Electrochemical Data Acquisition. Batter Supercaps e202300080. doi.org/10.1002/batt.202300080. Figure 1
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22

Kolosnitsyn, Dmitrii V., Nadezhda V. Egorova, Alena M. Ionina, Elena V. Kuzmina, Elena V. Karaseva, and Vladimir S. Kolosnitsyn. "Electrochemical characteristics of lithium-sulfur pouch cells. Effect of compression force of electrode modules." Electrochemical Energetics 25, no. 1 (2025): 10–22. https://doi.org/10.18500/1608-4039-2025-25-1-10-22.

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The effect of the electrode sizes, the cell design and the compression force of the electrode modules on the impedance and discharge characteristics of lithium-sulfur cells was studied. It was shown that Swagelok and pouch cells with identical electrodes have different electrochemical characteristics – charge transfer resistance, discharge capacity and cycling duration. It was found that the discharge capacity at the first cycle of Swagelok and pouch cells differs by 20% approximately. The capacity of pouch cells decreases faster during cycling. The cycling of pouch cells in a compressed state (similar to Swagelok cells) does not improve the electrochemical characteristics of pouch cells.
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Crowther, Owen. "Practical Considerations in the Development of 3 and 15 Ah Rechargeable Lithium Pouch Cells." ECS Meeting Abstracts MA2022-01, no. 1 (2022): 85. http://dx.doi.org/10.1149/ma2022-01185mtgabs.

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Commercially available Li-ion batteries using graphite or graphite-silicon blended anodes are currently approaching a cell level specific energy of 350 Wh kg−1. EaglePicher previously demonstrated a 2 Ah rechargeable pouch with a lithium metal anode that delivered 375 Wh kg−1 (Crowther, Owen. "Solving Barriers to Commercialization of Cells with Lithium Metal Anodes." 236th ECS Meeting (October 13-17, 2019). ECS, 2019). Further improvements to chemistry and cell design resulted in a 3 Ah pouch with longer cycle life and specific energies above 400 Wh kg−1 (Crowther, Owen. "Rechargeable Lithium Metal Pouch Cell Development." ECS Meeting Abstracts. No. 1. IOP Publishing, 2021). This paper will discuss several new areas that resulted in improved cell performance such as increasing the tab size, optimizing the electrolyte type and amount, and introducing excess lithium metal into the anode. Figure 1 demonstrates the rate capability of the cell with larger tabs to minimize the ohmic resistance. The cell with delivers ~425 Wh kg−1 at low rate and >300 Wh kg−1 at a 6.6C rate. The maximum continuous rate for the cell with the original tabs was 1C. Finally, the initial prototype performance of a 15 Ah rechargeable lithium pouch cell with a specific energy >500 Wh kg−1 will be highlighted. Figure 1
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Lin, Nan, Fridolin Röder, and Ulrike Krewer. "Multiphysics Modeling for Detailed Analysis of Multi-Layer Lithium-Ion Pouch Cells." Energies 11, no. 11 (2018): 2998. http://dx.doi.org/10.3390/en11112998.

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Multiphysics modeling permits a detailed investigation of complex physical interactions and heterogeneous performance in multiple electro-active layers of a large-format Li-ion cell. For this purpose, a novel 3D multiphysics model with high computational efficiency was developed to investigate detailed multiphysics heterogeneity in different layers of a large-format pouch cell at various discharge rates. This model has spatial distribution and temporal evolution of local electric current density, solid lithium concentration and temperature distributions in different electro-active layers, based on a real pouch cell geometry. Other than previous models, we resolve the discharge processes at various discharge C-rates, analyzing internal inhomogeneity based on multiple electro-active layers of a large-format pouch cell. The results reveal that the strong inhomogeneity in multiple layers at a high C-rate is caused by the large heat generation and poor heat dissipation in the direction through the cell thickness. The thermal inhomogeneity also strongly interacts with the local electrochemical and electric performance in the investigated cell.
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Condie, Brian G., and Qiaozhi Wei. "An in situ hybridization screen reveals new transcriptional regulators of third pharyngeal pouch and thymic epithelial cell differentiation. (86.12)." Journal of Immunology 182, no. 1_Supplement (2009): 86.12. http://dx.doi.org/10.4049/jimmunol.182.supp.86.12.

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Abstract Thymic epithelial cells (TECs) are the major component of the non-lymphoid framework of the thymus and are essential for normal T cell development. In mice, TECs develop from a domain of the embryonic third pharyngeal pouch endoderm marked by Foxn1 expression. Although Foxn1 is necessary for proliferation and differentiation of TECs, it is not required for specification of TECs from the pouch endoderm. Also, some aspects of TEC differentiation are Foxn1-independent. This suggests that there are additional transcription factors expressed within the third pouch endoderm that are responsible for early specification and differentiation of TECs. To identify additional transcriptional regulators of third pouch and TEC differentiation, we performed an in situ hybridization screen on a set of candidate transcription factors identified through a systematic analysis of gene expression databases. We found that most of the genes selected for detailed characterization were expressed in the third pharyngeal pouch endoderm and many of them were specifically expressed in the thymus domain of the pouch. These transcription factors are highly likely to be involved in the earliest steps of TEC development. Our work also shows that data mining of gene expression databases is an efficient way to identify genes involved in the development of a specific tissue or organ.
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Park, Bo Keun, Yong Min Kim, and Ki Jae Kim. "Analysis of Deterioration Mechanism of Al-Pouch Film Used As Packaging Materials for Lithium Ion Batteries." ECS Meeting Abstracts MA2022-01, no. 4 (2022): 531. http://dx.doi.org/10.1149/ma2022-014531mtgabs.

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Generally, lithium ion batteries (LIBs) can be divided into three different types: cylindrical, prismatic, and pouch-type LiBs with regard to the packaging form. Contrary to cylindrical or prismatic type batteries, pouch-type battery uses a pouch as an exterior material to protect inside of the cell from external influences, and have a metal lead-taps to receive and deliver electricity from external source. To safeguard the inside of the lithium ion battery, the pouch must have high resistance to gas and moisture permeability and excellent corrosion resistance to electrolytes. However, Al-pouch can be prone to contamination from electrolyte containing lithium salt during the electrolyte injection process, a key part of their manufacturing process. This electrolyte contamination can be fatal to the long-term reliability or durability of pouch-type LiBs. In this study, we investigate deterioration behavior of aluminium pouch film due to the electrolyte contamination. In order to clarify deterioration mechanism of Al-pouch film, we prepared exposure test of Al-pouch film and dummy cell samples which were stained by electrolyte droplet (LiPF6 in EC:EMC=1:2 (v/v) + 2 % VC). The change of micro-structure of the samples was tracked during 20 weeks by storing them under accelerated test conditions (RH 95 %, 60 ℃). As a result, we find out severe defect of the samples of Al-pouch film by damage to outermost nylon film and aluminium layer, and confirmed the effects on the battery after the defects occurred. To understand such phenomena, the micro-defect of Al-pouch films was observed by characterization techniques (XRD, FT-IR, SEM, EDX). We demonstrate that outermost layer of nylon film is damaged when it reacts with an electrolyte containing LiPF6 salt such as decreasing crystallinity, surface crazing, forming microdefects. The degradation of nylon film leads to severe surface cracking, followed by nylon locally peeling off from the Al-pouch. Peeling of the nylon film causes to expose the underlying thin aluminum film that constitute the middle layer of Al-pouch. Once partially exposed to the atmosphere, severe pitting corrosion of the aluminum film occurs due to atmospheric moisture and acids produced by LiPF6. Finally, a large amount of moisture to easily penetrate pouch-type LiBs through these corroded pits, showing the detrimental effects of electrolyte contamination on pouch-type LiBs’ long-term durability and reliability. Figure 1
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Timms, Robert, Scott G. Marquis, Valentin Sulzer, Colin P. Please, and S. Jonathan Chapman. "Asymptotic Reduction of a Lithium-Ion Pouch Cell Model." SIAM Journal on Applied Mathematics 81, no. 3 (2021): 765–88. http://dx.doi.org/10.1137/20m1336898.

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Orhan, Osman, and Adnan Özel. "Homogenized pouch cell material modelling and a comparison study." International Journal of Energy Research 45, no. 2 (2020): 2668–79. http://dx.doi.org/10.1002/er.5959.

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Tetangco, Eula Plana, Katrina Krogh, Guang-Yu Yang, and Emanuelle Bellaguarda. "Primary Signet Ring Cell Carcinoma of the Ileal Pouch." ACG Case Reports Journal 9, no. 1 (2022): e00713. http://dx.doi.org/10.14309/crj.0000000000000713.

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Altunbek, Mine, and Gulden Camci-Unal. "Origami-inspired heart pouch for minimally invasive cell delivery." Matter 5, no. 3 (2022): 777–79. http://dx.doi.org/10.1016/j.matt.2022.01.019.

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Kovachev, Schröttner, Gstrein, et al. "Analytical Dissection of an Automotive Li-Ion Pouch Cell." Batteries 5, no. 4 (2019): 67. http://dx.doi.org/10.3390/batteries5040067.

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Information derived from microscopic images of Li-ion cells is the base for research on the function, the safety, and the degradation of Li-ion batteries. This research was carried out to acquire information required to understand the mechanical properties of Li-ion cells. Parameters such as layer thicknesses, material compositions, and surface properties play important roles in the analysis and the further development of Li-ion batteries. In this work, relevant parameters were derived using microscopic imaging and analysis techniques. The quality and the usability of the measured data, however, are tightly connected to the sample generation, the preparation methods used, and the measurement device selected. Differences in specimen post-processing methods and measurement setups contribute to variability in the measured results. In this paper, the complete sample preparation procedure and analytical methodology are described, variations in the measured dataset are highlighted, and the study findings are discussed in detail. The presented results were obtained from an analysis conducted on a state-of-the-art Li-ion pouch cell applied in an electric vehicle that is currently commercially available.
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Wang, Lve, Bin Zhang, Jing Pang, et al. "Aging process analysis of LiNi0.88Co0.09Al0.03O2/graphite–SiOx pouch cell." Electrochimica Acta 286 (October 2018): 219–30. http://dx.doi.org/10.1016/j.electacta.2018.07.224.

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Chehl, Navdeep, Edwin McDonald, Bashar Almadani, et al. "T-Cell Lymphoma in a J-pouch After IPAA." American Journal of Gastroenterology 110 (October 2015): S290. http://dx.doi.org/10.14309/00000434-201510001-00656.

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Zhang, Xiaoxiao, Huainan Qu, Dantong Qiu, et al. "Li-S Solid State Pouch Cell with Flexible SSE." ECS Meeting Abstracts MA2023-01, no. 6 (2023): 1013. http://dx.doi.org/10.1149/ma2023-0161013mtgabs.

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An all-solid-state Li battery (ASSLB) is believed to be one of the most promising candidates to achieve high energy density of 500 Wh kg–1.After extensive exploration, several sulfide solid electrolytes have been synthesized with ionic conductivities in the order of 10–3 S cm–1 or even higher[1, 2]. With the successful development of various SSE materials, the major obstacle remaining is to demonstrate high energy density at a cell or battery level. Pelleting, dry processing, slurry coating, extrusion, and embedding into template have been explored for the manufacture of an SSE[3]. Despite the high energy density at the material-level and the electrode-level, the cell-level energy density of pellet format was still rather unsatisfactory (<50 Wh kg-1), which was mainly due to the thick SSE pellet (0.5–1 mm). Besides, the pelletizing process itself can only be limited to lab-scale research due to its high cost and poor practicability. To boost cell-level energy density and render the mass production feasible, sheet-type cells with a thin SSE and a thick cathode have been recognized as a “must-develop” technology within the battery community. Dry processing of SSE and electrode was developed using sulfur carbon as the cathode and sulfide Li6PS5Cl as the electrolyte. A small amount of PTFE (0.75% in SSE and 1% in cathode) was applied as the binder. After grinding and rolling at 80 oC, the sheet-type cathode (2*3.5 cm2) and SSE (2.4*3.9 cm2) with respective thickness of 90 and 200 um were obtained. With LiIn alloy as the anode, the pouch cell delivered a discharge capacity of 1200 mAh g–1 at 0.05C after the first cycle activation at 60 oC. The results indicated the feasibility of dry processing technology to fabricate sheet-type SSE and electrode. Figure 1. Voltage curves of the pouch cell during the first three cycles tested at 0.05C at 60 oC. (1) Kato, Y.; Hori, S.; Saito, T.; Suzuki, K.; Hirayama, M.; Mitsui, A.; Yonemura, M.; Iba, H.; Kanno, R. High-Power All-Solid-State Batteries Using Sulfide Superionic Conductors. Nat. Energy 2016, 1, 1–7. (2) Kamaya, N.; Homma, K.; Yamakawa, Y.; Hirayama, M.; Kanno, R.; Yonemura, M.; Kamiyama, T.; Kato, Y.; Hama, S.; Kawamoto, K.; Mitsui, A. A Lithium Superionic Conductor. Nat. Mater. 2011, 10, 682–686. (3) Emley, B.; Liang, Y.; Chen, R.; Wu, C.; Pan, M.; Fan, Z.; Yao, Y. On the Quality of Tape-Cast Thin Films of Sulfide Electrolytes for Solid-State Batteries. Mater. Today Phys. 2021, 18. 100397. Figure 1
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Heidrich, Bastian, Lars Pritzlaff, Markus Börner, Martin Winter, and Philip Niehoff. "Comparative X-ray Photoelectron Spectroscopy Study of the SEI and CEI in Three Different Lithium Ion Cell Formats." Journal of The Electrochemical Society 169, no. 3 (2022): 030533. http://dx.doi.org/10.1149/1945-7111/ac5c08.

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The solid electrolyte interphase (SEI) and cathode electrolyte interphase (CEI) of three lithium ion cell formats, i.e., coin, lab-scale pouch and multi-layer pouch, are compared. Half the cells are additionally dried prior to electrolyte filling and cycling. The highest water content per cell, determined by Karl Fischer titration, is found for lab-scale pouch cells due to their disadvantageous ratio of cell housing area to electrode area. The water content influences the performance during electrochemical formation as well as the impedance. This is linked to increasing lithium fluoride concentration, as determined by X-ray photoelectron spectroscopy. For dried cells, this is not the case because there is less conducting salt hydrolysis. The CEI thickness decreases for dried pouch cells, while the organic SEI thickness increases in all cell formats for dried cells. It is concluded that the initial thickness of the porous organic SEI depends on the insulation of the dense inorganic SEI close to the electrode surface. Organic species are more likely to contribute to negative electrode passivation when the extent of conducting salt hydrolysis is low. For coin cells, the presence of atmospheric gases during formation results in thicker SEI and CEI, no matter whether cells are additionally dried.
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36

Gao, Yue, Shu Chen, Jason Jolly, et al. "Resilient and Confined Polymer Microlattices for Low-Swelling, Pressure-Free Lithium Metal Pouch Cells." ECS Meeting Abstracts MA2024-02, no. 7 (2024): 776. https://doi.org/10.1149/ma2024-027776mtgabs.

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Automotive and consumer applications require batteries that last longer, recharge faster, and readily integrate into mass-manufactured battery packs. Of the available cell packaging designs, pouch cells with lithium (Li) metal anodes are attractive because they can achieve ~95% packaging efficiency, allow size and shape flexibility, and have high theoretical specific energy. Li metal anodes, however, suffer from dramatic thickness increases as they are cycled, which leads to pouch cell swelling of up to 220% by volume. Although current Li metal pouch cells incorporate alternative electrolytes, protective layers, and current collectors to prevent Li dendrite growth and stabilize the solid-electrolyte interphase (SEI), high initial external pressures of 54 to 1,000 kPa are required to suppress cell swelling and maintain stable Li deposition. Maintaining a high pressure is impractical in most applications, requires considerable extra mass and volume not accounted for in reported battery metrics, and increases the complexity of cooling. Despite these applied pressures, Li pouch cells still swell at least 39%, which is far from commercial requirements of less than 10%, causes serious safety issues, and makes integration incompatible with most electric devices. In a cell with 39% swelling, the Li anode swells up to 300% so that the final anode volume is four times the initial volume and the volumetric capacity is 33% of Li’s 2093 mAh cm-3 theoretical capacity, which is lower than the volumetric capacity of lithiated graphite (790 mAh cm-3). Additionally, these challenges are escalated in high-capacity and high-rate Li metal pouch cells. New Li electrode designs that provide control over interfacial chemistry while accommodating the extreme mechanics of Li plating and etching are required to break current technical bottlenecks for practical Li metal batteries. This talk will report the use of architected polymer microlattices that combine chemical and mechanical functions to enable high-rate, swelling-free, and pressure-free Li anodes and anode-less pouch cells. The 3D printed gyroidal polymer contains Li+ affinitive sites that accelerate Li+ transport and the gyroidal microgeometry is highly resilient and confines Li growth. Unlike prior Li anodes and porous Li scaffolds that need an SEI layer across large surface areas, 89% of the Li surface in the gyroid is covered by the polymer and the microgeometry is optimized so the remaining Li-electrolyte interface is protected by a LiF-rich SEI layer generated by F donating groups on the polymer. We study the LiF generated at the polymer and show that it moves up to 100 micrometers across the Li surface to enhance the anode stability. We also show how the combined chemical, mechanical, and geometric control allows dense and void-free Li metal to grow into complex 3D shapes. In a 5 mAh cm-2 pouch cell with zero external pressure, we demonstrate swelling-free Li deposition at 5-30 mA cm-2, or 1–6 C-rates, for over 100 cycles. Li deposition efficiency was 99.86% in a carbonate electrolyte with an areal capacity of 10 mAh cm-2 and 10 mA cm-2 current density. The Li anode achieved a 1,580 mAh cm-3 volumetric capacity. A 366 Wh kg-1 anode-less Li metal pouch cell (15.4 Ah) incorporating polymer microlattices on copper as the anode and a LiNi0.8Mn0.1Co0.1O2 (NMC) cathode achieved over 333 cycles with 80% capacity retention. The final cell swelling was below 2%. Insights into the excellent performance of these batteries can provide new paths towards achieving high rate and long life Li metal pouch cells with zero swelling. Figure Caption: Polymer microlattice enabling pressure-free and swelling-free Li metal pouch cells. a, During Li deposition, the growth and merging of Li particles generate voids even under a pressure of 54-1,000 kPa, causing cell swelling of 39-220%. b, Polymer microlattices confine Li deposition in the gyroidal channels through chemical interactions and mechanical resilience. The polymer contains -NH2 or CH2CH2O- groups to accelerate Li+ transport and -SO2F to generate LiF to protect the remaining Li surface. The crosslinked polymer is highly resilient and restrains Li for dense deposition. c,d,Cycling stability (a) and voltage profiles (b) of an anode-less Li metal pouch cell, presenting a cell-level energy density of 366 Wh kg-1. NMC was used as the cathode. e, The measurement of cell thickness upon cycling. 6 sampling points were collected. Figure 1
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37

Xiao, Jie. "(Invited) Controlled Large-Area Lithium Deposition to Reduce Swelling of High-Energy Lithium Metal Pouch Cells in Liquid Electrolytes." ECS Meeting Abstracts MA2024-02, no. 7 (2024): 789. https://doi.org/10.1149/ma2024-027789mtgabs.

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Lithium (Li) metal battery technology, renowned for its high energy density, faces practical challenges, particularly concerning large volume change and cell swelling. Despite the profound impact of external pressure on cell performance, there is a notable gap in research regarding the interplay between external pressure and electroplating behaviors of Li+ in large-format pouch cells. Here we delve into the impact of externally applied pressure on electroplating and stripping of Li in 350 Wh/kg pouch cells. Employing a hybrid design, we monitor and quantify self-generated pressures, correlating them with observed charge-discharge processes. A two-stage cycling process is proposed, revealing controlled pouch cell swelling of less than 10%, comparable to state-of-the-art Li-ion batteries. The pressure distribution across the cell surface unveils a complex Li+ detour behavior during electroplating, highlighting the need for innovative strategies to address uneven Li plating and enhance Li metal battery technology.
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38

Dutton-Regester, Kate, Tamara Keeley, Jane C. Fenelon, et al. "Plasma progesterone secretion during gestation of the captive short-beaked echidna." Reproduction 162, no. 4 (2021): 267–75. http://dx.doi.org/10.1530/rep-21-0110.

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This study describes the progesterone profile during pregnancy in sexually mature female captive short-beaked echidnas (Tachyglossus aculeatus aculeatus). Echidnas were monitored daily by video surveillance to confirm key reproductive behaviour. Plasma samples were collected and pouch morphology was assessed three times a week. The pouch of the female echidna only develops during gestation and it was possible to create a four-stage grading system using the most distinguishable characteristics of pouch development. Maximum pouch development was associated with declining progesterone concentrations, with the pouch closing in a drawstring-like manner at oviposition. Control of pouch development in pregnant echidnas is not yet clear but later pouch development is associated with a decrease in progesterone and pouch closure and may be under mechanical influences of the egg or young in the pouch. The length of pregnancy was 16.7 ± 0.2 days with a 15.1 ± 1.0 days luteal phase followed by an incubation period in the pouch. Eggs could be detected in utero at least 4 days before oviposition. Plasma progesterone peaked at 10.5 ± 0.9 ng/mL within 12 days of mating but then declined to basal levels within 1 day of oviposition and remained basal throughout egg incubation, confirming that progesterone is elevated throughout pregnancy and that gestation does not extend beyond the luteal phase. After the loss of an egg or pouch young, most females entered a second oestrous cycle and ovulated, suggesting echidnas are seasonally polyoestrous. The duration of the luteal phase in the echidna corresponds with that observed in other mammals.
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Choi, Seungyeop, Nayeon Kim, Dahee Jin, Youngjoon Roh, and Yong Min Lee. "Li Dendrite Formation on the Side of Cu Current Collector during Charging in Misaligned Pouch-Type Lithium-Ion Batteries." ECS Meeting Abstracts MA2023-01, no. 55 (2023): 2676. http://dx.doi.org/10.1149/ma2023-01552676mtgabs.

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Not only high-capacity electrode materials but also electrode/cell design greatly governs the electrochemical performance of LIBs. For instance, there are systematic works to unravel the effect of area or capacity ratio between anode and cathode or the electrolyte amount. [1,2,3] Especially, our research group has already reported the effect of electrode misalignment, which can frequently occur during the coin cell assembly, on the electrochemical properties, where Li dendrites formed on the coin cell bottom mainly deteriorated the cell performance. [4] However, considering the commercial cell configurations like pouch-type LIBs, which have insulating polypropylene inner layer, those negative phenomena should be evaluated in misaligned LIB cells. For this purpose, three pouch-type cells (well-aligned, slightly misaligned, and largely misaligned) using LixNi0.6Co0.2Mn0.2O2 cathode and graphite anode were fabricated in a dry room. Surprisingly, a similar misalignment effect to coin cells was also observed in the pouch-type cell, even though the inner layer of the Al-pouch is insulative. When we disassembled the misaligned cell after precycling, we could observe Li dendrites formed on the side of the Cu current collector (CC) of the anode. That is, the Li ions from the cathode are able to be plated on the metal side of Cu CC of a few micrometer thickness. Thus, even in pouch cells, the electrode misalignment can lead to Li inventory loss. To solve this problem, an insulating coating was applied to the side of the Cu CC, and as a result, the cycle performance of the misaligned cell was improved by suppressing the Li dendrite formation. In addition, the electrochemical characteristics were compared as a function of the lithiation state (SOL, x in LixNi0.6Co0.2Mn0.2O2) using EIS, DC-IR, XRD, etc. Reference B. Son, Y. M. Lee et al., J. Power Sources , 243 (2013) 641-647 R. Xue et al., J. Power Sources , 55 (1995) 111-114 B. R. Long, J. R. Croy et al., J. Electrochem. Soc. , 163 (2016) A2999 N. Kim, Y. M. Lee et al., J. Electrochem. Soc. , 169 (2022) 023502
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Fofana, Gaoussou Hadia, and You Tong Zhang. "Thermal Analysis of Li-ion Battery." Applied Mechanics and Materials 401-403 (September 2013): 450–55. http://dx.doi.org/10.4028/www.scientific.net/amm.401-403.450.

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Abstract. The paper has built 3D-FEA models to simulate the electro-thermal behavior of Li-ion battery cells with Pouch Cell and Prismatic Cell by ANSYS. As for two models, the Li-ion battery system is simplified as a single equivalent battery layer (Pouch Cell) or multiple equivalent battery layers (Prismatic Cell) with the equivalent electrodes and separator. They were simulated under air cooling conditions. Simulations were compared with available battery temperature measurements. This shows that the 3D electro-thermal model applied in this study characterizes the electro-thermal behavior of the Li-ion battery cells reasonably well.
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Wang, Peng, and Petru Andrei. "Efficient Zn-Ion Pouch Cell Assembling Based on Aramid Nanofiber Hydrogel." ECS Meeting Abstracts MA2024-01, no. 53 (2024): 2803. http://dx.doi.org/10.1149/ma2024-01532803mtgabs.

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With the fast advancement of portable and wearable electronics, it is urgent to develop safe, stable and flexible power supply devices. Safe and environmentally friendly aqueous zinc-ion batteries (AZIBs) have a low-cost and are perfect candidates for energy storage device in such applications [1-4]. Giving the general challenges, such as the formation of the dendrites on the Zn anodes and hydrogen evolution and side reactions, extensive and wide research has focused on building stable AZIBs with high performance, but less attention was paid to making Zn ion pouch cells which are flexible and with high capacity In this presentation, we developed an efficient method to assemble Zn-ion pouch cells based on the process of formation of the aramid nanofiber hydrogel. The method involves the dipping precursor solution, solvent exchanging, and in-situ electrodeposition of MnO2. The assembled Zn-ion pouch cells exhibit excellent mechanical performance, flexibility and electrochemical performance, which are ideal for portable and wearable electronics. Based on this method, we successfully assembled 3-layer (cathode/anode/cathode, A/C/A) and 5 layer (A/C/A/C/A) pouch cells with over 100 times higher capacity compared with coin cell. In addition, the pouch cell with aramid nanofiber hydrogel and in-situ electrodeposited MnO2 cathode on carbon nanotube mat demonstrates superior cycling stability [5,6]. More details about our assembling method for flexible and stable pouch cells for AZIBs and experimental measurements related to the cycling and stability characteristics, will be presented at the meeting. [1] Yu, Peng, et al. "Flexible Zn‐ion batteries: recent progresses and challenges." Small 15.7 (2019): 1804760. [2] Li, Yingbo, et al. "Recent advances in flexible zinc‐based rechargeable batteries." Advanced Energy Materials 9.1 (2019): 1802605. [3] Li, Chunyang, et al. "High-rate and high-voltage aqueous rechargeable zinc ammonium hybrid battery from selective cation intercalation cathode." ACS Applied Energy Materials 2.10 (2019): 6984-6989. [4] Yu, Feng, et al. "Aqueous alkaline–acid hybrid electrolyte for zinc-bromine battery with 3V voltage window." Energy Storage Materials 19 (2019): 56-61. [5] Wang, Peng, and Petru Andrei. "High Performance Separator and Hydrogel Based on Aramid Fibers for Zn Ion Batteries." Electrochemical Society Meeting Abstracts 242. No. 4. The Electrochemical Society, Inc., 2022. [6] Xu, Lizhi, et al. "Water‐rich biomimetic composites with abiotic self‐organizing nanofiber network." Advanced Materials 30.1 (2018): 1703343.
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Shin, Yewon, Mingyu Lee, and Hongkyung Lee. "Real-Time, Non-Invasive Magnetic Field Imaging for Diagnosing Current Flow Patterns inside Fault-Simulated Li-Ion Batteries." ECS Meeting Abstracts MA2023-01, no. 2 (2023): 635. http://dx.doi.org/10.1149/ma2023-012635mtgabs.

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With the growing popularity of Li-ion batteries in electric-powered mobility, securing battery safety has become a common goal of the battery community. Battery failures are commonly caused by small, undetectable defects that can form during manufacturing and operation, ranging from materials to the cell level. Although the small errors inside the cells trigger catastrophic failures, tracing them and distinguishing cell failure modes without cell anatomy remains challenging. Given that several defects within the cell could cause abnormal current flow compared to the normal cells, visualization of the current inside the battery is informative to find and trace the invisible defects that cannot be detected using imaging tools for the internal structure of fully packaged commercial cells. This study presents a real-time, non-invasive magnetic field imaging (MFI) method that can signal the magnetic field induced by battery current flow inside the Li-ion pouch cell during cycling (Figure 1). MFI can offer high-speed scanning in a few minutes (~100 mm/min) and spatially high resolution (0.161 mm2) and immediately measure the magnetic field with no need for shielding commonly required for MRI measurement. Based on the Biot-Savart law, we validated magnetic field-current correlation through the MFI of current-carrying 1D straight wires and 2D planes. Then, we found the optimal pouch cell structure for visualizing the current flow patterns using MFI and successfully converted the MFI contour map of the pouch cells into the normalized current distribution. To demonstrate the efficacy of current pattern analysis, we have collected MFI results of fault-simulated batteries (FSBs) to distinguish failure modes that intentionally possess cell manufacturing faults, such as lead-tab contact failure, electrode alignment, and stacking faults. Magnetic field offset using countercurrent-carrying, pouch cell-shaped 2D conductor underneath can selectively detect the failure spots where the current abnormally flows. It is believed that direct visualization of current distribution patterns and figuring out the pattern changes during operation can expedite the non-destructive, immediate diagnosis of commercial cells and troubleshoot safety-related challenges. Figure 1. Single-layer pouch cells and in operando MFI analysis during charging. (a) Scheme for internal structure of single-layer pouch cell (60 × 90 mm2) with counter-side, center-aligned tabs (CS-C cell). (b) Actual image of CS-C cell and MFI scan and applied current directions during the cell charging. MFI mapping images for (c) Bx , (d) By and (e) Bz vector fields at the cell. White arrows within each MFI contour map indicate the current flow prediction. Applying current density: 5.09 mA cm−2, the cell was situated 6 mm below the sensor (z-distance: 2.5 mm, scanned side: Cathode-side up). The total number of scanned data points are 1699 (11 cm) and 64 (16 cm) in y- and x-directions, respectively. Figure 1
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Whittle, Sara, Donald C. Swartzendruber, Mary Kremer, Christopher A. Squier, and Philip W. Wertz. "Lipids of hamster cheek pouch epithelium." Lipids 32, no. 9 (1997): 961–64. http://dx.doi.org/10.1007/s11745-997-0124-y.

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Gimenez-Conti, Irma B., and Thomas J. Slaga. "The hamster cheek pouch carcinogenesis model." Journal of Cellular Biochemistry 53, S17F (1993): 83–90. http://dx.doi.org/10.1002/jcb.240531012.

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45

Romano, M., R. Faggioni, M. Sironi, et al. "Carrageenan-induced acute inflammation in the mouse air pouch synovial model. Role of tumour necrosis factor." Mediators of Inflammation 6, no. 1 (1997): 32–38. http://dx.doi.org/10.1080/09629359791901.

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We used the mouse air pouch model of inflammation to study the interaction between cytokines, prostaglandin E2(PGE2) and cell migration during the various phases of acute local inflammation induced by carrageenan. In serum, the levels of interleukin 1 (IL-1), interleukin 6 (IL-6), tumour necrosis factor (TNF), serum amiloid-A (SAA) and Fe++were never different from controls, indicating that no systemic inflammatory changes were induced. Locally the exudate volume and the number of leukocytes recruited into the pouch increased progressively until 7 days after carrageenan. The same was true for PGE2production. We could not measure IL-1 but the production of IL-6 and TNF reached a maximum after 5-24 h then quickly decreased. Anti-TNF antibodies inhibited cell migration by 50% 24 h after treatment. Pretreatment with interleukin 10 (IL-10) inhibited TNF production almost completely and cell migration by 60%. Carrageenan-induced inflammation was modulated by anti-inflammatory drugs. Pretreatment with dexamethasone (DEX) or indomethacin (INDO) inhibited cell migration and reduced the concentration of TNF in the exudate. Production of PGE2or vascular permeability did not correlate with the number of cells in the pouch. Local TNF seems to play an important role in this model, particularly for leukocyte migration in the first phase of the inflammatory process. In conclusion, the air pouch seems to be a good model for studying the regulation of the early events of local inflammation, particularly the role of cytokines and cell migration.
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46

Kim, Hong-Keun, and Kyu-Jin Lee. "Scale-Up of Physics-Based Models for Predicting Degradation of Large Lithium Ion Batteries." Sustainability 12, no. 20 (2020): 8544. http://dx.doi.org/10.3390/su12208544.

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Large lithium-ion batteries (LIBs) demonstrate different performance and lifetime compared to small LIB cells, owing to the size effects generated by the electrical configuration and property imbalance. However, the calculation time for performing life predictions with three-dimensional (3D) cell models is undesirably long. In this paper, a lumped cell model with equivalent resistances (LER cell model) is proposed as a reduced order model of the 3D cell model, which enables accurate and fast life predictions of large LIBs. The developed LER cell model is validated via the comparisons with results of the 3D cell models by simulating a 20-Ah commercial pouch cell (NCM/graphite) and the experimental values. In addition, the LER cell models are applied to different cell types and sizes, such as a 20-Ah cylindrical cell and a 60-Ah pouch cell.
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47

Liu, Dongqiang, Chisu Kim, Alexis Perea, et al. "High-Voltage Lithium-Ion Battery Using Substituted LiCoPO4: Electrochemical and Safety Performance of 1.2 Ah Pouch Cell." Materials 13, no. 19 (2020): 4450. http://dx.doi.org/10.3390/ma13194450.

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A LiCoPO4-based high-voltage lithium-ion battery was fabricated in the format of a 1.2 Ah pouch cell that exhibited a highly stable cycle life at a cut-off voltage of 4.9 V. The high-voltage stability was achieved using a Fe-Cr-Si multi-ion-substituted LiCoPO4 cathode and lithium bis(fluorosulfonyl)imide in 1-methyl-1-propylpyrrolidinium bis(fluorosulfony)imide as the electrolyte. Due to the improved electrochemical stability at high voltage, the cell exhibited a stable capacity retention of 91% after 290 cycles without any gas evolution related to electrolyte decomposition at high voltage. In addition to improved cycling stability, the nominal 5 V LiCoPO4 pouch cell also exhibited excellent safety performance during a nail penetration safety test compared with a state-of-the-art lithium ion battery. Meanwhile, the thermal stabilities of the 1.2 Ah pouch cell as well as the delithiated LiCoPO4 were also studied by accelerating rate calorimetry (ARC), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and in situ X-ray diffraction (XRD) analyses and reported.
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48

Takuma, N., H. Z. Sheng, Y. Furuta, et al. "Formation of Rathke's pouch requires dual induction from the diencephalon." Development 125, no. 23 (1998): 4835–40. http://dx.doi.org/10.1242/dev.125.23.4835.

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Targeted disruption of the homeobox gene T/ebp (Nkx2.1, Ttf1, Titf1) in mice results in ablation of the pituitary. Paradoxically, while T/ebp is expressed in the ventral diencephalon during forebrain formation, it is not expressed in Rathke's pouch or in the pituitary gland at any time of embryogenesis. Examination of pituitary development in the T/ebp homozygous null mutant embryos revealed that a pouch rudiment is initially formed but is eliminated by programmed cell death before formation of a definitive pouch. In the diencephalon of the mutant, Bmp4 expression is maintained, whereas Fgf8 expression is not detectable. These data and additional genetic and molecular observations suggest that Rathke's pouch develops in a two-step process that requires at least two sequential inductive signals from the diencephalon. First, BMP4 is required for induction and formation of the pouch rudiment, a role confirmed by analysis of Bmp4 homozygous null mutant embryos. Second, FGF8 is necessary for activation of the key regulatory gene Lhx3 and subsequent development of the pouch rudiment into a definitive pouch. This study provides firm molecular genetic evidence that morphogenesis of the pituitary primordium is induced in vivo by signals from the adjacent diencephalon.
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MicCurrie, Hudube, Gwatidzo Oscar, and Tigere Godfrey. "A comparative review of pneumatic cylinders and magnetic actuators in the design of automatic pouch cell folding machines: Implications for Zimbabwe's battery manufacturing industry." i-manager's Journal on Mechanical Engineering 15, no. 1 (2025): 28. https://doi.org/10.26634/jme.15.1.21721.

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The global shift toward renewable energy and electric vehicles (EVs) has increased the demand for Lithium-Ion batteries, particularly pouch cells. Automatic pouch cell folding machines are essential for ensuring the precision and efficiency of battery manufacturing. In Zimbabwe, where the mining of Lithium, a key raw material for batteries, is expanding, the development of a local battery manufacturing industry presents a significant economic opportunity. This paper compares two key actuation technologies, pneumatic cylinders and magnetic actuators, in the context of designing automatic pouch cell folding machines. The analysis considers factors such as performance, energy efficiency, precision, maintenance, and cost, with a focus on their applicability to Zimbabwe's Industrial and economic landscape. The paper concludes with recommendations for adopting the most suitable technology to support Zimbabwe's emerging battery manufacturing sector.
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50

Hamed, Hamid, Behnam Ghalami Choobar, Sarallah Hamtaei, Jan D’Haen, Bart Vermang, and Mohammadhosein Safari. "Experimental Investigation of a 64 Ah Lithium-Ion Pouch Cell." Journal of The Electrochemical Society 171, no. 2 (2024): 020510. http://dx.doi.org/10.1149/1945-7111/ad24c2.

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This study presents a meticulous investigation and characterization of a 64 Ah commercial lithium-ion pouch cell. Notably, an exhaustive analysis of the cell’s open-circuit voltage and kinetics attributes is conducted, with particular emphasis on the temperature-dependent dynamics. Subsequently, a teardown experiment is performed, offering an incisive insight into the macro-geometrical properties underpinning the cell’s architecture. Further details about the microstructural features and formulation inherent to the cathode and anode are revealed after image processing of the electrodes’ cross sections. The details of cell balancing and cycling window of the electrodes in the pouch cell are determined and discussed based on the open-circuit-voltage measurements of the individual electrodes and a simple optimization algorithm. The methodologies presented in this work are insightful on the characterization and model parametrization of the high-capacity commercial lithium-ion cells.
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