Relevant bibliographies by topics / Poxa-48

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Academic literature on the topic 'Poxa-48'

Author: Grafiati
Published: 13 July 2024
Last updated: 31 July 2025

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Journal articles on the topic "Poxa-48"

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Brehony, Carina, Elaine McGrath, Wendy Brennan, et al. "An MLST approach to support tracking of plasmids carrying OXA-48-like carbapenemase." Journal of Antimicrobial Chemotherapy 74, no. 7 (2019): 1856–62. http://dx.doi.org/10.1093/jac/dkz136.

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AbstractObjectivesThe prevalence of infections caused by OXA-48-like carbapenemase-producing organisms in Ireland has increased dramatically since 2011 and is an urgent public health issue. Genome-based high-resolution genotyping was used to analyse clinical isolates submitted to the Irish Carbapenemase-Producing Enterobacteriaceae Reference Laboratory Service for a 13 month period (2016–17).MethodsA total of 109 OXA-48-producing non-duplicate clinical isolates from 16 submitting centres were sequenced. Using a gene-by-gene approach, isolate genomes were characterized by MLST and core genome M
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Poirel, Laurent, Rémy A. Bonnin, and Patrice Nordmann. "Genetic Features of the Widespread Plasmid Coding for the Carbapenemase OXA-48." Antimicrobial Agents and Chemotherapy 56, no. 1 (2011): 559–62. http://dx.doi.org/10.1128/aac.05289-11.

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ABSTRACTComplete sequencing of plasmid pOXA-48a carrying theblaOXA-48gene from aKlebsiella pneumoniaeisolate was performed. Its backbone corresponded to that of an IncL/M-type plasmid, in which theblaOXA-48gene had been integrated through the acquisition of the Tn1999composite transposon without any other antibiotic resistance gene. Molecular epidemiology using a collection of international OXA-48 producers revealed the wide diffusion of pOXA-48a or closely related plasmids.
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3

Pérez-Viso, Blanca, Marta Hernández-García, Manuel Ponce-Alonso, et al. "Characterization of carbapenemase-producing Serratia marcescens and whole-genome sequencing for plasmid typing in a hospital in Madrid, Spain (2016–18)." Journal of Antimicrobial Chemotherapy 76, no. 1 (2020): 110–16. http://dx.doi.org/10.1093/jac/dkaa398.

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Abstract Objectives Carbapenemase-producing Enterobacterales (CPE) are increasingly recognized in nosocomial infections, also affecting ICU patients. We aimed to characterize the carbapenemase-producing Serratia marcescens (CPSm) isolates recovered in our hospital in Madrid (Spain) between March 2016 and December 2018. Methods Overall, 50 isolates from clinical and epidemiological surveillance samples were recovered from 24 patients admitted to the medical ICU and 10 non-ICU-related patients based on their phenotypic resistance. Carbapenemase characterization, antibiotic susceptibility, PFGE c
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Potron, Anaïs, Laurent Poirel, and Patrice Nordmann. "Derepressed Transfer Properties Leading to the Efficient Spread of the Plasmid Encoding Carbapenemase OXA-48." Antimicrobial Agents and Chemotherapy 58, no. 1 (2013): 467–71. http://dx.doi.org/10.1128/aac.01344-13.

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ABSTRACTThe current emergence of the carbapenemase OXA-48 amongEnterobacteriaceaeis related to the spread of a single IncL/M-type plasmid, pOXA-48a. This plasmid harbors theblaOXA-48gene within a composite transposon, Tn1999, which is inserted into thetirgene, encoding a transfer inhibition protein. We showed that the insertion of Tn1999into thetirgene was involved in a higher transfer frequency of plasmid pOXA-48a. This may likely be the key factor for the successful dissemination of this plasmid.
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Irrgang, Alexandra, Natalie Pauly, Bernd-Alois Tenhagen, Mirjam Grobbel, Annemarie Kaesbohrer, and Jens A. Hammerl. "Spill-Over from Public Health? First Detection of an OXA-48-Producing Escherichia coli in a German Pig Farm." Microorganisms 8, no. 6 (2020): 855. http://dx.doi.org/10.3390/microorganisms8060855.

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Resistance to carbapenems is a severe threat to human health. These last resort antimicrobials are indispensable for the treatment of severe human infections with multidrug-resistant Gram-negative bacteria. In accordance with their increasing medical impact, carbapenemase-producing Enterobacteriaceae (CPE) might be disseminated from colonized humans to non-human reservoirs (i.e., environment, animals, food). In Germany, the occurrence of CPE in livestock and food has been systematically monitored since 2016. In the 2019 monitoring, an OXA-48-producing E. coli (19-AB01443) was recovered from a
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Shi, Qiucheng, Xinhong Han, Qin Huang, et al. "The Genetic Characteristics and Carbapenem Resistance Mechanism of ST307 Klebsiella pneumoniae Coharbouring blaCMY-6, blaOXA-48, and a Truncated blaNDM-1." Antibiotics 11, no. 11 (2022): 1616. http://dx.doi.org/10.3390/antibiotics11111616.

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Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a common nosocomial pathogen causing severe infectious diseases, and ST307 CRKP is an emerging clone. In this study, we collected five ST307 CRKP isolates, evaluated their antimicrobial susceptibility using microbroth dilution, and their clonality and population structure by PFGE, cgMLST, and SNP-based phylogenetic analysis. Then, the genome characteristics, such as antimicrobial resistance genes and plasmid profiles, were studied by subsequent genomic analysis. The plasmid transfer ability was evaluated by conjugation, and the carbapenem re
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7

David, Sophia, Victoria Cohen, Sandra Reuter, et al. "Integrated chromosomal and plasmid sequence analyses reveal diverse modes of carbapenemase gene spread among Klebsiella pneumoniae." Proceedings of the National Academy of Sciences 117, no. 40 (2020): 25043–54. http://dx.doi.org/10.1073/pnas.2003407117.

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Molecular and genomic surveillance systems for bacterial pathogens currently rely on tracking clonally evolving lineages. By contrast, plasmids are usually excluded or analyzed with low-resolution techniques, despite being the primary vectors of antibiotic resistance genes across many key pathogens. Here, we used a combination of long- and short-read sequence data of Klebsiella pneumoniae isolates (n = 1,717) from a European survey to perform an integrated, continent-wide study of chromosomal and plasmid diversity. This revealed three contrasting modes of dissemination used by carbapenemase ge
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8

Tsui, Clement, Fatma Ben Abid, Christi L. McElheny, et al. "1247. Molecular Epidemiology of Multi-drug Resistant Klebsiella pneumoniae and K. quasipneumoniae in Qatar." Open Forum Infectious Diseases 8, Supplement_1 (2021): S712. http://dx.doi.org/10.1093/ofid/ofab466.1439.

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Abstract Background The molecular epidemiology of carbapenem-resistant Klebsiella species is not well investigated in Qatar. The objective of this work was to characterize the genetic context of carbapenemase-producing Klebsiella isolates recovered from clinical specimens. Methods Klebsiella isolates (n=100) were collected at 7 tertiary hospitals from 2015-2017. Identification and susceptibility testing were performed using MALDI-TOF MS and BD Phoenix system, respectively. Whole Genome Sequencing was performed on the Illumina NextSeq platform. Phylogenomic analysis, screening of resistance and
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Hendrickx, Antoni P. A., Fabian Landman, Angela de Haan, Sandra Witteveen, Marga G. van Santen-Verheuvel, and Leo M. Schouls. "bla OXA-48-like genome architecture among carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in the Netherlands." Microbial Genomics 7, no. 5 (2021). http://dx.doi.org/10.1099/mgen.0.000512.

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Carbapenem-hydrolysing enzymes belonging to the OXA-48-like group are encoded by bla OXA-48-like alleles and are abundant among Enterobacterales in the Netherlands. Therefore, the objective here was to investigate the characteristics, gene content and diversity of the bla OXA-48-like carrying plasmids and chromosomes of Escherichia coli and Klebsiella pneumoniae collected in the Dutch national surveillance from 2014 to 2019 in comparison with genome sequences from 29 countries. A combination of short-read genome sequencing with long-read sequencing enabled the reconstruction of 47 and 132 comp
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10

Skalova, Anna, Katerina Chudejova, Veronika Rotova, et al. "Molecular Characterization of OXA-48-Like-Producing Enterobacteriaceae in the Czech Republic and Evidence for Horizontal Transfer of pOXA-48-Like Plasmids." Antimicrobial Agents and Chemotherapy 61, no. 2 (2016). http://dx.doi.org/10.1128/aac.01889-16.

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ABSTRACT The aim of this study was to characterize the first cases and outbreaks of OXA-48-like-producing Enterobacteriaceae recovered from hospital settings in the Czech Republic. From 2013 to 2015, 22 Klebsiella pneumoniae isolates, 3 Escherichia coli isolates, and 1 Enterobacter cloacae isolate producing OXA-48-like carbapenemases were isolated from 20 patients. Four of the patients were colonized or infected by two or three different OXA-48-like producers. The K. pneumoniae isolates were classified into nine sequence types (STs), with ST101 being predominant (n = 8). The E. coli isolates w
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Dissertations / Theses on the topic "Poxa-48"

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Zongo, Pengdbamba Dieudonné. "Contribution de l'intégration du gène blaOXA-48 dans la dissémination des clones ST38 d'Escherichia coli producteurs de carbapénémase." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS084.

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Les carbapénèmes sont des ß-lactamines de dernière génération utilisées comme dernier recours dans le traitement des infections causées par les bactéries Gram négatifs multirésistantes. L'efficacité thérapeutique de cette classe d'antibiotiques est menacée avec l'apparition et la dissémination de clones résistants aux carbapénèmes dont certains sont porteurs de plasmides codant pour des carbapénémases, OXA-48 étant la carbapénémase prédominante en Europe. En France, les bactéries Escherichia coli productrices de carbapénémase les plus répandues appartiennent au séquence type (ST) 38, dans lequ
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