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Journal articles on the topic 'Poxa-48'

Author: Grafiati

Published: 13 July 2024

Last updated: 31 July 2025

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1

Brehony, Carina, Elaine McGrath, Wendy Brennan, et al. "An MLST approach to support tracking of plasmids carrying OXA-48-like carbapenemase." Journal of Antimicrobial Chemotherapy 74, no. 7 (2019): 1856–62. http://dx.doi.org/10.1093/jac/dkz136.

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AbstractObjectivesThe prevalence of infections caused by OXA-48-like carbapenemase-producing organisms in Ireland has increased dramatically since 2011 and is an urgent public health issue. Genome-based high-resolution genotyping was used to analyse clinical isolates submitted to the Irish Carbapenemase-Producing Enterobacteriaceae Reference Laboratory Service for a 13 month period (2016–17).MethodsA total of 109 OXA-48-producing non-duplicate clinical isolates from 16 submitting centres were sequenced. Using a gene-by-gene approach, isolate genomes were characterized by MLST and core genome M

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2

Poirel, Laurent, Rémy A. Bonnin, and Patrice Nordmann. "Genetic Features of the Widespread Plasmid Coding for the Carbapenemase OXA-48." Antimicrobial Agents and Chemotherapy 56, no. 1 (2011): 559–62. http://dx.doi.org/10.1128/aac.05289-11.

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ABSTRACTComplete sequencing of plasmid pOXA-48a carrying theblaOXA-48gene from aKlebsiella pneumoniaeisolate was performed. Its backbone corresponded to that of an IncL/M-type plasmid, in which theblaOXA-48gene had been integrated through the acquisition of the Tn1999composite transposon without any other antibiotic resistance gene. Molecular epidemiology using a collection of international OXA-48 producers revealed the wide diffusion of pOXA-48a or closely related plasmids.

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3

Pérez-Viso, Blanca, Marta Hernández-García, Manuel Ponce-Alonso, et al. "Characterization of carbapenemase-producing Serratia marcescens and whole-genome sequencing for plasmid typing in a hospital in Madrid, Spain (2016–18)." Journal of Antimicrobial Chemotherapy 76, no. 1 (2020): 110–16. http://dx.doi.org/10.1093/jac/dkaa398.

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Abstract Objectives Carbapenemase-producing Enterobacterales (CPE) are increasingly recognized in nosocomial infections, also affecting ICU patients. We aimed to characterize the carbapenemase-producing Serratia marcescens (CPSm) isolates recovered in our hospital in Madrid (Spain) between March 2016 and December 2018. Methods Overall, 50 isolates from clinical and epidemiological surveillance samples were recovered from 24 patients admitted to the medical ICU and 10 non-ICU-related patients based on their phenotypic resistance. Carbapenemase characterization, antibiotic susceptibility, PFGE c

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Potron, Anaïs, Laurent Poirel, and Patrice Nordmann. "Derepressed Transfer Properties Leading to the Efficient Spread of the Plasmid Encoding Carbapenemase OXA-48." Antimicrobial Agents and Chemotherapy 58, no. 1 (2013): 467–71. http://dx.doi.org/10.1128/aac.01344-13.

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ABSTRACTThe current emergence of the carbapenemase OXA-48 amongEnterobacteriaceaeis related to the spread of a single IncL/M-type plasmid, pOXA-48a. This plasmid harbors theblaOXA-48gene within a composite transposon, Tn1999, which is inserted into thetirgene, encoding a transfer inhibition protein. We showed that the insertion of Tn1999into thetirgene was involved in a higher transfer frequency of plasmid pOXA-48a. This may likely be the key factor for the successful dissemination of this plasmid.

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Irrgang, Alexandra, Natalie Pauly, Bernd-Alois Tenhagen, Mirjam Grobbel, Annemarie Kaesbohrer, and Jens A. Hammerl. "Spill-Over from Public Health? First Detection of an OXA-48-Producing Escherichia coli in a German Pig Farm." Microorganisms 8, no. 6 (2020): 855. http://dx.doi.org/10.3390/microorganisms8060855.

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Resistance to carbapenems is a severe threat to human health. These last resort antimicrobials are indispensable for the treatment of severe human infections with multidrug-resistant Gram-negative bacteria. In accordance with their increasing medical impact, carbapenemase-producing Enterobacteriaceae (CPE) might be disseminated from colonized humans to non-human reservoirs (i.e., environment, animals, food). In Germany, the occurrence of CPE in livestock and food has been systematically monitored since 2016. In the 2019 monitoring, an OXA-48-producing E. coli (19-AB01443) was recovered from a

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6

Shi, Qiucheng, Xinhong Han, Qin Huang, et al. "The Genetic Characteristics and Carbapenem Resistance Mechanism of ST307 Klebsiella pneumoniae Coharbouring blaCMY-6, blaOXA-48, and a Truncated blaNDM-1." Antibiotics 11, no. 11 (2022): 1616. http://dx.doi.org/10.3390/antibiotics11111616.

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Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a common nosocomial pathogen causing severe infectious diseases, and ST307 CRKP is an emerging clone. In this study, we collected five ST307 CRKP isolates, evaluated their antimicrobial susceptibility using microbroth dilution, and their clonality and population structure by PFGE, cgMLST, and SNP-based phylogenetic analysis. Then, the genome characteristics, such as antimicrobial resistance genes and plasmid profiles, were studied by subsequent genomic analysis. The plasmid transfer ability was evaluated by conjugation, and the carbapenem re

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7

David, Sophia, Victoria Cohen, Sandra Reuter, et al. "Integrated chromosomal and plasmid sequence analyses reveal diverse modes of carbapenemase gene spread among Klebsiella pneumoniae." Proceedings of the National Academy of Sciences 117, no. 40 (2020): 25043–54. http://dx.doi.org/10.1073/pnas.2003407117.

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Molecular and genomic surveillance systems for bacterial pathogens currently rely on tracking clonally evolving lineages. By contrast, plasmids are usually excluded or analyzed with low-resolution techniques, despite being the primary vectors of antibiotic resistance genes across many key pathogens. Here, we used a combination of long- and short-read sequence data of Klebsiella pneumoniae isolates (n = 1,717) from a European survey to perform an integrated, continent-wide study of chromosomal and plasmid diversity. This revealed three contrasting modes of dissemination used by carbapenemase ge

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Tsui, Clement, Fatma Ben Abid, Christi L. McElheny, et al. "1247. Molecular Epidemiology of Multi-drug Resistant Klebsiella pneumoniae and K. quasipneumoniae in Qatar." Open Forum Infectious Diseases 8, Supplement_1 (2021): S712. http://dx.doi.org/10.1093/ofid/ofab466.1439.

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Abstract Background The molecular epidemiology of carbapenem-resistant Klebsiella species is not well investigated in Qatar. The objective of this work was to characterize the genetic context of carbapenemase-producing Klebsiella isolates recovered from clinical specimens. Methods Klebsiella isolates (n=100) were collected at 7 tertiary hospitals from 2015-2017. Identification and susceptibility testing were performed using MALDI-TOF MS and BD Phoenix system, respectively. Whole Genome Sequencing was performed on the Illumina NextSeq platform. Phylogenomic analysis, screening of resistance and

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Hendrickx, Antoni P. A., Fabian Landman, Angela de Haan, Sandra Witteveen, Marga G. van Santen-Verheuvel, and Leo M. Schouls. "bla OXA-48-like genome architecture among carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in the Netherlands." Microbial Genomics 7, no. 5 (2021). http://dx.doi.org/10.1099/mgen.0.000512.

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Carbapenem-hydrolysing enzymes belonging to the OXA-48-like group are encoded by bla OXA-48-like alleles and are abundant among Enterobacterales in the Netherlands. Therefore, the objective here was to investigate the characteristics, gene content and diversity of the bla OXA-48-like carrying plasmids and chromosomes of Escherichia coli and Klebsiella pneumoniae collected in the Dutch national surveillance from 2014 to 2019 in comparison with genome sequences from 29 countries. A combination of short-read genome sequencing with long-read sequencing enabled the reconstruction of 47 and 132 comp

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Skalova, Anna, Katerina Chudejova, Veronika Rotova, et al. "Molecular Characterization of OXA-48-Like-Producing Enterobacteriaceae in the Czech Republic and Evidence for Horizontal Transfer of pOXA-48-Like Plasmids." Antimicrobial Agents and Chemotherapy 61, no. 2 (2016). http://dx.doi.org/10.1128/aac.01889-16.

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ABSTRACT The aim of this study was to characterize the first cases and outbreaks of OXA-48-like-producing Enterobacteriaceae recovered from hospital settings in the Czech Republic. From 2013 to 2015, 22 Klebsiella pneumoniae isolates, 3 Escherichia coli isolates, and 1 Enterobacter cloacae isolate producing OXA-48-like carbapenemases were isolated from 20 patients. Four of the patients were colonized or infected by two or three different OXA-48-like producers. The K. pneumoniae isolates were classified into nine sequence types (STs), with ST101 being predominant (n = 8). The E. coli isolates w

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Alonso-del Valle, Aida, Laura Toribio-Celestino, Anna Quirant, et al. "Antimicrobial resistance level and conjugation permissiveness shape plasmid distribution in clinical enterobacteria." Proceedings of the National Academy of Sciences 120, no. 51 (2023). http://dx.doi.org/10.1073/pnas.2314135120.

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Conjugative plasmids play a key role in the dissemination of antimicrobial resistance (AMR) genes across bacterial pathogens. AMR plasmids are widespread in clinical settings, but their distribution is not random, and certain associations between plasmids and bacterial clones are particularly successful. For example, the globally spread carbapenem resistance plasmid pOXA-48 can use a wide range of enterobacterial species as hosts, but it is usually associated with a small number of specific Klebsiella pneumoniae clones. These successful associations represent an important threat for hospitaliz

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Marti, Roger, Roger Stephan, Jochen Klumpp, et al. "Complete Genome Sequence of Enterobacter cloacae 704SK10, an OXA-48-Encoding Wastewater Isolate." Genome Announcements 5, no. 33 (2017). http://dx.doi.org/10.1128/genomea.00830-17.

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ABSTRACT Here we present the complete genome sequence of Enterobacter cloacae 704SK10, a Swiss wastewater isolate encoding an OXA-48 carbapenemase. Assembly resulted in closed sequences of the 4,876,946-bp chromosome, a 111,184-bp IncF plasmid, and an OXA-48-encoding IncL plasmid (63,458 bp) nearly identical to the previously described plasmid pOXA-48.

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Fernández-Calvet, Ariadna, Laura Toribio-Celestino, Aida Alonso-del Valle, et al. "The distribution of fitness effects of plasmid pOXA-48 in clinical enterobacteria." Microbiology 169, no. 7 (2023). http://dx.doi.org/10.1099/mic.0.001369.

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Antimicrobial resistance (AMR) in bacteria is a major public health problem. The main route for AMR acquisition in clinically important bacteria is the horizontal transfer of plasmids carrying resistance genes. AMR plasmids allow bacteria to survive antibiotics, but they also entail physiological alterations in the host cell. Multiple studies over the last few years have indicated that these alterations can translate into a fitness cost when antibiotics are absent. However, due to technical limitations, most of these studies are based on analysing new associations between plasmids and bacteria

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Zongo, Pengdbamba Dieudonné, Nicolas Cabanel, Guilhem Royer, et al. "An antiplasmid system drives antibiotic resistance gene integration in carbapenemase-producing Escherichia coli lineages." Nature Communications 15, no. 1 (2024). http://dx.doi.org/10.1038/s41467-024-48219-y.

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AbstractPlasmids carrying antibiotic resistance genes (ARG) are the main mechanism of resistance dissemination in Enterobacterales. However, the fitness-resistance trade-off may result in their elimination. Chromosomal integration of ARGs preserves resistance advantage while relieving the selective pressure for keeping costly plasmids. In some bacterial lineages, such as carbapenemase producing sequence type ST38 Escherichia coli, most ARGs are chromosomally integrated. Here we reproduce by experimental evolution the mobilisation of the carbapenemase blaOXA-48 gene from the pOXA-48 plasmid int

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Ledda, Alice, Martina Cummins, Liam P. Shaw, et al. "Hospital outbreak of carbapenem-resistant Enterobacterales associated with a bla OXA-48 plasmid carried mostly by Escherichia coli ST399." Microbial Genomics 8, no. 4 (2022). http://dx.doi.org/10.1099/mgen.0.000675.

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A hospital outbreak of carbapenem-resistant Enterobacterales was detected by routine surveillance. Whole genome sequencing and subsequent analysis revealed a conserved promiscuous bla OXA-48 carrying plasmid as the defining factor within this outbreak. Four different species of Enterobacterales were involved in the outbreak. Escherichia coli ST399 accounted for 35 of all the 55 isolates. Comparative genomics analysis using publicly available E. coli ST399 genomes showed that the outbreak E. coli ST399 isolates formed a unique clade. We developed a mathematical model of pOXA-48-like plasmid tra

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Smit, Pieter W., Carla van Tienen, Fabian Landman, et al. "Diversification of bla OXA-48-harbouring plasmids among carbapenemase-producing Enterobacterales, 11 years after a large outbreak in a general hospital in the Netherlands." Microbial Genomics 11, no. 1 (2025). https://doi.org/10.1099/mgen.0.001335.

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Introduction. Genes encoding OXA-48-like carbapenem-hydrolyzing enzymes are often located on plasmids and are abundant among carbapenemase-producing Enterobacterales (CPE) worldwide. After a large bla OXA-48 plasmid-mediated outbreak in 2011, routine screening of patients at risk of CPE carriage on admission and every 7 days during hospitalization was implemented in a large hospital in the Netherlands. The objective of this study was to investigate the dynamics of the hospitals’ 2011 outbreak-associated bla OXA-48 plasmid among CPE collected from 2011 to 2021. Methods. A selection of 86 bla OX

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Chen, Ying, Li Fang, Yunxing Yang, et al. "Emergence of carbapenem-resistant Klebsiella pneumoniae harbouring bla OXA-48-like genes in China." Journal of Medical Microbiology 70, no. 3 (2021). http://dx.doi.org/10.1099/jmm.0.001306.

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Klebsiella pneumoniae strains carrying OXA-48-like carbapenemases are increasingly prevalent across the globe. There is thus an urgent need to better understand the mechanisms that underpin the dissemination of bla OXA-48-like carbapenemases. To this end, four ertapenem-resistant K. pneumoniae isolates producing OXA-48-like carbapenemases were isolated from two patients. Genome sequencing revealed that one sequence type (ST) 17 isolate carried bla OXA-181, whilst three isolates from a single patient, two ST76 and one ST15, carried bla OXA-232. The 50514 bp bla OXA-181-harbouring plasmid, pOXA-

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David, Sophia, Massimo Mentasti, Kirsty Sands, et al. "Genomic surveillance of multidrug-resistant Klebsiella in Wales reveals persistent spread of Klebsiella pneumoniae ST307 and adaptive evolution of pOXA-48-like plasmids." Microbial Genomics 9, no. 5 (2023). http://dx.doi.org/10.1099/mgen.0.001016.

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Rising rates of multidrug-resistant Klebsiella infections necessitate a comprehensive understanding of the major strains and plasmids driving spread of resistance elements. Here, we analysed 540 clinical, screen and environmental Klebsiella isolates recovered from across Wales between 2007 and 2020 using combined short- and long-read sequencing approaches. We identified resistant clones that have spread within and between hospitals including the high-risk strain sequence type (ST)307, which acquired the bla OXA-244 carbapenemase gene on a pOXA-48-like plasmid. We found evidence that this strai

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Nielsen, Karen Leth, Marc Sørensen, Frederik Boëtius Hertz, et al. "Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021." Eurosurveillance 28, no. 17 (2023). http://dx.doi.org/10.2807/1560-7917.es.2023.28.17.2300196.

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A hypervirulent Klebsiella pneumoniae SL218 (ST23-KL57), phylogenetically distinct from the classical hypervirulent SL23 (ST23-KL1) lineage, was transmitted between hospitalised patients in Denmark in 2021. The isolate carried a hybrid resistance and virulence plasmid containing bla NDM-1 and a plasmid containing bla OXA-48 (pOXA-48); the latter plasmid was horizontally transferred within-patient to Serratia marcescens. The convergence of drug resistance and virulence factors in single plasmids and in different lineages of K. pneumoniae is concerning and requires surveillance.

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Dabos, Laura, Pierre Bogaerts, Remy A. Bonnin та ін. "Genetic and Biochemical Characterization of OXA-519, a Novel OXA-48-Like β-Lactamase". Antimicrobial Agents and Chemotherapy 62, № 8 (2018). http://dx.doi.org/10.1128/aac.00469-18.

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ABSTRACT A multidrug-resistant Klebsiella pneumoniae 1210 isolate with reduced carbapenem susceptibility revealed the presence of a novel plasmid-encoded blaOXA-48-like gene, named blaOXA-519. The 60.7-kb plasmid (pOXA-519) was similar to the IncL-OXA-48 prototypical plasmid except for a ca. 2-kb deletion due to an IS1R insertion. OXA-519 differed from OXA-48 by a Val120Leu substitution, which resulted in an overall reduced β-lactam-hydrolysis profile, except those for ertapenem and meropenem, which were increased. Thus, detection of OXA-519 producers using biochemical tests that monitor imipe

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Hao, Mingju, Yuzhang He, Haifang Zhang, et al. "CRISPR-Cas9-Mediated Carbapenemase Gene and Plasmid Curing in Carbapenem-Resistant Enterobacteriaceae." Antimicrobial Agents and Chemotherapy 64, no. 9 (2020). http://dx.doi.org/10.1128/aac.00843-20.

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ABSTRACT Combating plasmid-mediated carbapenem resistance is essential to control and prevent the dissemination of carbapenem-resistant Enterobacteriaceae (CRE). Here, we conducted a proof-of-concept study to demonstrate that CRISPR-Cas9-mediated resistance gene and plasmid curing can effectively resensitize CRE to carbapenems. A novel CRISPR-Cas9-mediated plasmid-curing system (pCasCure) was developed and electrotransferred into various clinical CRE isolates. The results showed that pCasCure can effectively cure blaKPC, blaNDM, and blaOXA-48 in various Enterobacteriaceae species of Klebsiella

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Brehony, Carina, Lisa Domegan, Margaret Foley, et al. "Molecular epidemiology of an extended multiple-species OXA-48 CPE outbreak in a hospital ward in Ireland, 2018–2019." Antimicrobial Stewardship & Healthcare Epidemiology 1, no. 1 (2021). http://dx.doi.org/10.1017/ash.2021.206.

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Abstract Objectives: Molecular epidemiological description of an OXA-48 CPE outbreak affecting a tertiary-care hospital ward in Ireland over an extended period (2018–2019). Methods: Microbiological testing and whole-genome sequencing (WGS) were performed on all 56 positive OXA-48 outbreak case isolates. Results: In total, 7 different species were identified: Enterobacter hormaechei (n = 35, 62.5%), Escherichia coli (n = 12, 21.4%), Klebsiella pneumoniae (n = 5, 8.9%), Klebsiella oxytoca (n = 1, 1.8%), Klebsiella michiganensis (n = 1, 1.8%), Citrobacter freundii (n = 1, 1.8%), and Serratia marc

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Hernández-García, Marta, Ricardo León-Sampedro, Blanca Pérez-Viso, et al. "First Report of an OXA-48- and CTX-M-213-ProducingKluyveraSpecies Clone Recovered from Patients Admitted in a University Hospital in Madrid, Spain." Antimicrobial Agents and Chemotherapy 62, no. 11 (2018). http://dx.doi.org/10.1128/aac.01238-18.

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ABSTRACTEnterobacteralesspecies other thanKlebsiella pneumoniaealso contribute to OXA-48 carbapenemase endemicity. We studied the emergence of an OXA-48-producingKluyveraspecies clone, which expresses the novel CTX-M-213 enzyme, colonizing patients in our hospital. Rectal swabs from patients admitted in four wards (March 2014 to March 2016; R-GNOSIS project) were seeded onto Chromo ID-ESBL) and Chrom-CARB/OXA-48 chromogenic agar plates. Carbapenemases and extended-spectrum β-lactamases (ESBLs) were characterized (PCR, sequencing, cloning, and site-directed mutagenesis), and antibiotic suscepti

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Herencias, Cristina, Jerónimo Rodríguez-Beltrán, Ricardo León-Sampedro, et al. "Collateral sensitivity associated with antibiotic resistance plasmids." eLife 10 (January 20, 2021). http://dx.doi.org/10.7554/elife.65130.

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Collateral sensitivity (CS) is a promising alternative approach to counteract the rising problem of antibiotic resistance (ABR). CS occurs when the acquisition of resistance to one antibiotic produces increased susceptibility to a second antibiotic. Recent studies have focused on CS strategies designed against ABR mediated by chromosomal mutations. However, one of the main drivers of ABR in clinically relevant bacteria is the horizontal transfer of ABR genes mediated by plasmids. Here, we report the first analysis of CS associated with the acquisition of complete ABR plasmids, including the cl

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Alexandra, Irrgang, Pauly Natalie, Tenhagen Bernd-Alois, Grobbel Mirjam, Kaesbohrer Annemarie, and A. Hammerl Jens. "Spill-Over from Public Health? First Detection of an OXA-48-Producing Escherichia coli in a German Pig Farm." June 5, 2020. https://doi.org/10.3390/microorganisms8060855.

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Abstract: Resistance to carbapenems is a severe threat to human health. These last resort antimicrobials are indispensable for the treatment of severe human infections with multidrug-resistant Gram-negative bacteria. In accordance with their increasing medical impact, carbapenemase-producing Enterobacteriaceae (CPE) might be disseminated from colonized humans to non-human reservoirs (i.e., environment, animals, food). In Germany, the occurrence of CPE in livestock and food has been systematically monitored since 2016. In the 2019 monitoring, an OXA-48-producing E. coli(19-AB01443) was recovere

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Rima, Mariam, Saoussen Oueslati, Garance Cotelon, et al. "Role of amino acid 159 in carbapenem and temocillin hydrolysis of OXA-933, a novel OXA-48 variant." Antimicrobial Agents and Chemotherapy, March 25, 2024. http://dx.doi.org/10.1128/aac.00180-24.

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ABSTRACT OXA-48 has rapidly disseminated worldwide and become one of the most common carbapenemases in many countries with more than 45 variants reported with, in some cases, significant differences in their hydrolysis profiles. The R214 residue, located in the ß5-ß6 loop, is crucial for the carbapenemase activity, as it stabilizes carbapenems in the active site and maintains the shape of the active site through interactions with D159. In this study, we have characterized a novel variant of OXA-48, OXA-933 with a single D159N change. To evaluate the importance of this residue, point mutations

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Hadjadj, Linda, Nadim Cassir, Nadia Saïdani, et al. "Outbreak of carbapenem-resistant enterobacteria in a thoracic-oncology unit through clonal and plasmid-mediated transmission of the blaOXA-48 gene in Southern France." Frontiers in Cellular and Infection Microbiology 12 (December 7, 2022). http://dx.doi.org/10.3389/fcimb.2022.1048516.

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BackgroundCarbapenemase-producing Enterobacteriaceae (CPE) represent an increasing threat to public health, especially in hospitals.ObjectivesTo investigate an outbreak of CPE in a thoracic-oncology unit by using whole genome sequencing (WGS) and to describe the control measures taken to limit the epidemic, including fecal microbiota transplantation (FMT).MethodsA retrospective study between December 2016 and October 2017 was performed to investigate an outbreak of CPE in a thoracic-oncology unit at the North Hospital in Marseille, France. The isolates were identified, and antimicrobial suscep

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Yao, Yancheng, Linda Falgenhauer, Jane Falgenhauer, et al. "Carbapenem-Resistant Citrobacter spp. as an Emerging Concern in the Hospital-Setting: Results From a Genome-Based Regional Surveillance Study." Frontiers in Cellular and Infection Microbiology 11 (November 11, 2021). http://dx.doi.org/10.3389/fcimb.2021.744431.

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The rise of Carbapenem-resistant Enterobacterales (CRE) represents an increasing threat to patient safety and healthcare systems worldwide. Citrobacter spp., long considered not to be a classical nosocomial pathogen, in contrast to Klebsiella pneumoniae and Escherichia coli, is fast gaining importance as a clinical multidrug-resistant pathogen. We analyzed the genomes of 512 isolates of 21 CRE species obtained from 61 hospitals within a three-year-period and found that Citrobacter spp. (C. freundii, C. portucalensis, C. europaeus, C. koseri and C. braakii) were increasingly detected (n=56) wit

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Gibbon, Marjorie J., Natacha Couto, Sophia David, et al. "A high prevalence of bla OXA-48 in Klebsiella (Raoultella) ornithinolytica and related species in hospital wastewater in South West England." Microbial Genomics 7, no. 3 (2021). http://dx.doi.org/10.1099/mgen.0.000509.

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Klebsiella species occupy a wide range of environmental and animal niches, and occasionally cause opportunistic infections that are resistant to multiple antibiotics. In particular, Klebsiella pneumoniae (Kpne) has gained notoriety as a major nosocomial pathogen, due principally to the rise in non-susceptibility to carbapenems and other beta-lactam antibiotics. Whilst it has been proposed that the urban water cycle facilitates transmission of pathogens between clinical settings and the environment, the level of risk posed by resistant Klebsiella strains in hospital wastewater remains unclear.

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Gibbon, Marjorie J., Natacha Couto, Sophia David, et al. "A high prevalence of bla OXA-48 in Klebsiella (Raoultella) ornithinolytica and related species in hospital wastewater in South West England." Microbial Genomics, January 8, 2021. http://dx.doi.org/10.1099/mgen.0.000509.

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Klebsiella species occupy a wide range of environmental and animal niches, and occasionally cause opportunistic infections that are resistant to multiple antibiotics. In particular, Klebsiella pneumoniae (Kpne) has gained notoriety as a major nosocomial pathogen, due principally to the rise in non-susceptibility to carbapenems and other beta-lactam antibiotics. Whilst it has been proposed that the urban water cycle facilitates transmission of pathogens between clinical settings and the environment, the level of risk posed by resistant Klebsiella strains in hospital wastewater remains unclear.

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Pathak, Ayush, Daniel C. Angst, Ricardo León-Sampedro, and Alex R. Hall. "Antibiotic-degrading resistance changes bacterial community structure via species-specific responses." ISME Journal, June 29, 2023. http://dx.doi.org/10.1038/s41396-023-01465-2.

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AbstractSome bacterial resistance mechanisms degrade antibiotics, potentially protecting neighbouring susceptible cells from antibiotic exposure. We do not yet understand how such effects influence bacterial communities of more than two species, which are typical in nature. Here, we used experimental multispecies communities to test the effects of clinically important pOXA-48-plasmid-encoded resistance on community-level responses to antibiotics. We found that resistance in one community member reduced antibiotic inhibition of other species, but some benefitted more than others. Further experi

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Yang, Chengcheng, Liang Wang, Jingnan Lv, et al. "Effects of different carbapenemase and siderophore production on cefiderocol susceptibility in Klebsiella pneumoniae." Antimicrobial Agents and Chemotherapy, October 29, 2024. http://dx.doi.org/10.1128/aac.01019-24.

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ABSTRACT The resistance mechanism of Gram-negative bacteria to the siderophore antibiotic cefiderocol is primarily attributed to carbapenemase and siderophore uptake pathways; however, specific factors and their relationships remain to be fully elucidated. Here, we constructed cefiderocol-resistant Klebsiella pneumoniae (CRKP) strains carrying different carbapenemases and knocked out siderophore genes to investigate the roles of various carbapenemases and siderophores in the development of cefiderocol resistance. Antimicrobial susceptibility testing revealed that both bla NDM and bla KPC signi

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