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Dissertations / Theses on the topic 'PPAP synthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Sow, Boubacar. "Development of the Domino Pericyclic Oxy-Cope/Ene /Claisen /Diels-Alder Reaction and the Synthesis of Complex Bicyclo[3.3.1]alkenones." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30344.

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This thesis is a dissertation to support the development of new domino pericyclic oxy-Cope/ene/Claisen/Diels-Alder reaction, diversity oriented synthesis of PPAPs scaffold via sequential one pot cascade reaction and ethyl aluminum sesquichloride catalyzed highly hindered Diels-Alder reaction. The first part concentrates on the domino pericyclic oxy-Cope/ene/Claisen/Diels-Alder reaction. As a result of this study, we have developed a general methodology for rapidly constructing complex diterpenes and discovered a thermal oxy-Cope/ene/Claisen/Claisen rearrangement, applied to the synthesis of t

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2

Barabe, Francis. "Gold(I)-Catalyzed Synthesis of Polycyclic Frameworks Related to Terpenes: Selective Divergent Synthesis of Fused Carbocycles." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/29055.

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Gold catalysis has become an important tool to achieve highly chemoselective p-acid activation. Exceptional reactivity and selectivity are often encountered under mild reaction conditions. These properties have made gold(I) complexes suitable catalysts for tremendous applications in the total synthesis of natural products. The first chapter will highlight a number of total syntheses using gold catalysis as a key step. The second chapter will cover our application of the gold(I)-catalyzed 6-endo-dig carbocyclization for the synthesis of bridgehead-substituted scaffolds and its use toward the

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3

Bellavance, Gabriel. "Part A: Development of a Modular Synthetic Approach to Polycyclic Polyprenylated Acylphlorogluginols: Total Synthesis of Papuaforin A, B, C, Hyperforin and Formal Synthesis of Nemorosone. Part B: Studies Toward the Synthesis of Ginkgolides." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34630.

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Polycyclic Polyprenylated Acylphloroglucinols (PPAPs) are a vast family of natural products, which includes more than 200 members. They contain a stunningly complex molecular architecture which in most cases includes a bicyclo[3.3.1]nonane core. PPAPs have been of interest to the scientific community for their intricate structure, their powerful aid in treating many ailments and large portfolio of biological activities. More particularly, they have been of synthetic interest since 1999 with the first report of an approach to these complicated cores by Nicolaou. Herein, we present the first tot

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4

Lui, Chih-Hung. "Molecular design and synthesis of coumarin fluorescent dyes." Thesis, Heriot-Watt University, 2000. http://hdl.handle.net/10399/572.

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5

Mudiyanselage, Pushpa Suresh Jayasekara. "PROGRESS TOWARDS THE SYNTHESIS OF TYPE B POLYCYCLIC POLYPRENYLATED ACYLPHLOROGLUCINOL 7-epi-CLUSIANONE." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/758.

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Plants of the family Guttiferae produce polycyclic polyprenylated acylphloroglucinols (PPAPs), which have interesting biological activities including anticancer and antibacterial properties. The main structural features of PPAPs comprise of bicyclo[3.3.1]nonane-2,4,9-triketone with one acyl group together with prenyl, geranyl, or other C10H17 groups. 7-epi-Clusianone, a type B PPAP with C-7 endo stereochemistry, is being approached by establishing the cis relationship with C(4) allyl group and C(2) methyl ester in the early stage of the synthesis. Then C(2) methyl ester is converted to alkyne

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6

Almeida, Cotrim Bruno. "Synthesis of fatty acid derivatives of catechol compounds that exhibit negative modulation of food intake and antioxidant properties." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/22690.

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Obesity constitutes a problem whose manifestations have consequences in almost every field of the medicine and nowadays there is a lack of pharmacological therapy alternatives for its long term treatment. Lipidic compounds as endocannabinoids and PPAR-α ligands are known to play an important role in the modulation of appetite and metabolism. Three series of fatty acid derivatives of catechol compounds were synthesized and their biological activity evaluated. Some of the synthesized compounds presented LDL antioxidant activity and/or food intake modulation in an animal model and their

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7

Delman, Emily. "Effects of Synthetic Ligands onHeterodimer Pairs Regarding Full-Length Human PPARa, RXRa and LXRa." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1472204976.

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8

Schmitt, Stefanie [Verfasser], and Johann [Akademischer Betreuer] Jauch. "Untersuchungen zur Totalsynthese von PPAPs: Formale Synthese von Nemoroson / Stefanie Schmitt ; Betreuer: Johann Jauch." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://d-nb.info/1132581826/34.

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9

Bhurruth, Anju Hina Yushma. "Design and synthesis of novel PPAR agonists for the treatment of the metabolic syndrome and diabetes type II." Thesis, Imperial College London, 2007. http://hdl.handle.net/10044/1/11878.

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10

Mizuno, Cassia S. "Design and synthesis of novel dual PPAR gamma agonists/angiotensin II antagonists for treatment of type II diabetes and hypertension /." Full text available from ProQuest UM Digital Dissertations, 2006. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1317317411&SrchMode=1&sid=5&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1197925156&clientId=22256.

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11

Meyer, Maxime. "Conception et synthèse de nouvelles molécules bioactives duales : vers des composés antagonistes AT1 et agonistes PPAR[gamma]." Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0221.

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Certains antagonistes du récepteur AT1 (« angiotensin II type 1 receptors ») utilisés dans le traitement de l'hypertension artérielle ont par la suite également montré une activité au niveau de PPAR[gamma] (« Peroxisome Proliferator Activated Receptor [gamma] »), un récepteur impliqué dans la régulation du métabolisme du glucose. Cela constitue une nouvelle approche thérapeutique vers un traitement concomitant de l'hypertension artérielle et du diabète de type II, qui sont souvent associés. Dans ce contexte, nous nous sommes dirigés vers la conception rationnelle de molécules capables d'intera

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12

Kress, Brian J. "Synthesis of Novel Small Molecule PPARδ Agonists for Controlling Mesenchymal Stem Cell Osteogenesis". University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1564751044043639.

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13

Eskandari, Roozbeh. "DEVELOPMENT OF NOVEL SYNTHETIC ROUTES TO THE EPOXYKETOOCTADECANOIC ACIDS (EKODES) AND THEIR BIOLOGICAL EVALUATION AS ACTIVATORS OF THE PPAR FAMILY OF NUCLEAR RECEPTORS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1441365802.

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14

Nigro, Julie. "The role of PPAR-α ligands (fibrates) in the regulation of vascular smooth muscle proteoglycan synthesis and structure as a contributor to reduced lipoprotein binding and the development of atherosclerosis". Monash University, Dept. of Medicine, 2004. http://arrow.monash.edu.au/hdl/1959.1/5464.

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15

Wong, Yung-Sing. "Nouveaux intermediaires chiraux de type 1,4-dihydropyridine et equivalents de sels de 3,4-dihydropyridinium pour la synthese asymetrique de piperidines polysubstituees. Application a la synthese enantioselective du 3-ppp et de l'indolizidine 195b." Paris 11, 1994. http://www.theses.fr/1994PA112105.

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L'application de la reaction de zincke a des amines primaires enantiomeriquement pures a donne des sels de pyridinium portant un centre asymetrique directement fixe sur l'azote, a partir de la pyridine correspondante, substituee ou non en position 3. L'etude de la reduction par le dithionite de sodium de ces sels a conduit de maniere efficace a de nouveaux intermediaires 1,4-dihydropyridines chiraux. La reduction des sels n-substitues par une chaine phenylethanol donne des 1,4-dihydropyridines qui s'isomerisent en 3,7,8,8a-tetrahydro-2h-oxazolo3,2-apyridines. Une etude structurale a ete entrep

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16

Fromentin, Yann. "Extraction et hémisynthèse d'analogues de la guttiférone A." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05P633.

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La guttiférone A , appartenant à la famille des PPAPs ou Acyle Phloroglucinol Polycycliques Polyprénylées, est une molécule extraite à partir d’un arbre tropicale, le Symphonia globulifera. Cette matière première est abondante et peut être facilement obtenue. De plus, elle présente de nombreuses activités biologiques, lui conférant un potentiel pharmacologique très intéressant. Trois approches ont été effectuées durant ces travaux. La première fût l’utilisation de microorganismes pour effectuer des biotransformations. L’utilisation de levures a permis de synthétiser la 3,16-oxy-guttiférone A,

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17

Shrestha, Prashanta. "Streamlined Extract Preparation for E. coli-Based Cell-Free Protein Synthesis and Rapid Site-Specific Incorporation of Unnatural Amino Acids in Proteins." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3917.

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This thesis reports the viability of E. coli cell extracts prepared using equipment that is both common to biotechnology laboratories and able to process small volume samples and expression of proteins containing unnatural amino acids (UAAs) at higher level using PCR amplified linear DNA templates (LETs) in cell-free protein synthesis (CFPS) system. E. coli-based cell extracts are a vital component of inexpensive and high-yielding CFPS reactions. However, effective preparation of E. coli cell extract is limited to high-pressure homogenizers (French press style or impinge-style) or bead mill ho

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18

Juen, Ludovic. "Synthèse et évaluation biologique d'inhibiteurs de STAT5 dans le traitement des leucémies myéloïdes." Thesis, Tours, 2016. http://www.theses.fr/2016TOUR3811/document.

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Les leucémies, syndromes myéloprolifératifs et myelodysplasiques sont la première cause de cancer chez l’enfant de moins de 15 ans. Les facteurs de transcription STAT5 ont un rôle indispensable dans la genèse et le maintien des leucémies. L’inhibition de STAT5 contribuerait à diminuer la survie, l’auto-renouvellement et la quiescence des cellules leucémiques ainsi que leur résistance potentielle aux agents anti-cancéreux. Suite à un précédent criblage de notre chimiothèque, un dérivé comprenant un noyau 4,4-diméthyl-1,2,3,4-tétrahydroquinoléine lié à un indole par une chaine éthoxy, a été iden

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19

Bera, Mrinal Kanti. "Towards The Total Synthesis Of Polycyclic Polyprenylated Acyl Phloroglucin (PPAP) Natural Products : Garsubellin A And Hyperforin." Thesis, 2008. http://hdl.handle.net/2005/760.

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Organic synthesis has a rich history, ever since Friedrich Wohler’s synthesis of urea from ammonium cyanate in 1828 that gave birth to this important discipline of science. While organic synthesis has found many application and witnessed many triumphs in improving the quality of life, it is the creative instinct, reminiscent of art, associated with this discipline that holds special appeal. This creative flair finds its best expression in the domain of natural product synthesis, which has witnessed spectacular advances and attainments, particularly in the second half of the 20th century . M

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20

Boyce, Jonathan Henry. "Total syntheses of polycyclic polyprenylated acylphloroglucinol natural products and analogs utilizing alkylative dearomatizations and cationic cyclizations." Thesis, 2017. https://hdl.handle.net/2144/24108.

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Polycyclic polyprenylated acylphloroglucinols (PPAPs) are structurally complex natural products with promising biological activities. These compounds have interesting anticancer and anti-HIV properties as well as other biological activities making them highly attractive synthetic targets. We report a stereodivergent, asymmetric total synthesis of (−)-clusianone in six steps from commercial materials. We have implemented a challenging cationic cyclization forging a bond between two sterically encumbered quaternary carbon atoms. Mechanistic studies point to the unique ability of formic acid to

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21

Lin, Chia-Hui, and 林家輝. "Design and Synthesis of Novel PPAR Agonists as Anti-Diabetic Agents." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/29181804487902052728.

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博士<br>國立清華大學<br>化學系<br>96<br>This dissertation is concerned with the discovery of novel PPAR�� agonists for oral antidiabetic therapy through SBDD (Structure Based Drug Design). The work is divided into two parts: the first part is the development of a series of novel indole-based analogs including structure based design, chemosynthesis and structural biology and structure-activity relationship (SAR), the second part is a series of quinoline-based analogs including drug design, chemosynthesis, structural biology and structure-activity relationship. In the first part, a series of novel indole

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22

Li, Yue. "Peroxisome proliferator-activated receptor (PPAR) alpha regulation of highly unsaturated fatty acid synthesis /." 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3242920.

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Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006.<br>Source: Dissertation Abstracts International, Volume: 67-11, Section: B, page: 6317. Adviser: Manabu T. Nakamura. Includes bibliographical references (leaves 81-92) Available on microfilm from Pro Quest Information and Learning.

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23

Pan, Chen-Yu, та 潘振宇. "Over-Expression Proliferator Proliferator-Activated Receptor Gamma(PPAR γ)Enhance Lipid Synthesis in Zebrafish". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/03276870332522264184.

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碩士<br>國立臺灣海洋大學<br>生物科技研究所<br>102<br>PPAR-γ (Peroxisome proliferator-activated receptor gamma) is a transcription factor, regulates lipid metabolism and adipocyte differentionaion in human and mice,but in zebrafish it`s still uncertain. In previeus study, over-expression PPAR-γ lead lipid accumulation in mice. Here we eatablish a PPAR-γ over-expressed zebrafish plaform to study lipid metabolism gene network. Over-expressed PPAR-γ leads lipid accumulation in zebrafish. The lipid accumulation level depend on fat containing rate of diet. We can eatablish lipid metabolic disease models to probe it

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24

Syha, Yvonne [Verfasser]. "Synthese und in-vitro-pharmakologische Charakterisierung von dualen PPARα/γ-Agonisten [PPAR-alpha-gamma-Agonisten] / von Yvonne Syha". 2006. http://d-nb.info/979340403/34.

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25

Chen, Wei-Chih, and 陳韋志. "Synthesis of All-Conjugated Block Copolymers PPP-P3EHT by Using Grignard Metathesis and Study of Co-Crystallization, Self-Assembly and Optoelectronic Properties." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/59176325323786383600.

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碩士<br>國立臺灣大學<br>高分子科學與工程學研究所<br>101<br>In this study, we synthesized a series of monodisperse all-conjugated BCPs of poly(2,5-dihexyloxy-p-phenylene)-b-poly(3-(2-ethylhexyl)thiophene) (PPP-P3EHT) with different block ratios by varying P3EHT to a nealy fixed PPP molecular weight to detail their self-assembly and crystallization behavior. Gel permeation chromatographer and NMR spectra were used to characterize the block copolymers. Wherein driven by molecular affinity and balance in the crystallization kinetics, the ability to co-crystallize dissimilar yet self-crystallizable blocks of a block c

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26

Yang, Yi-Lung, and 楊宜龍. "Synthesis and Self-Assembly of All-conjugated PPP-P3BT Rod-Rod Block Copolymers via Grignard Metathesis Polymerization and Their Applications in Nanohybrid System." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/49957833008058464177.

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博士<br>國立臺灣大學<br>高分子科學與工程學研究所<br>102<br>Recently, all-conjugated block copolymers of the rod-rod type has been developed into a new kind of conjugated polymer materials, and came into the focus of interest because of their unique and attractive combination of optoelectronic activity and controllable nanostructure formation. Compared with coil-based block copolymer systems, there is considerable interest for the co-self-assembly behavior of rod-rod block copolymer system in organic electronics applications. The co-self-assembly behavior of a rod-rod system is further complicated due to the prese

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27

Boteanu, Popescu Laura Nicoleta [Verfasser]. "Synthese und Struktur-Wirkungs-Beziehungen von dualen PPARα/γ-Modulatoren [PPAR-alpha-gamma-Modulatoren] mit 5-Lo-inhibitorischen Eigenschaften / von Laura Nicoleta Boteanu Popescu". 2009. http://d-nb.info/1007823054/34.

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28

Kumar, Chittimalla Santhosh, and 紀森多士. "PartI: The Diels-Alder Reactions of 6,6-Dimethoxycyclohexa-2,4-dienones Generated by Pyrolysis of their Dimers; PartII: Design, Synthesis and In Vitro Studies of Novel PPAR Agonists as Anti-Diabetic Agents." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/35824789436568765989.

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博士<br>國立清華大學<br>化學系<br>93<br>ABSTRACT This thesis consists of two parts Part I, gives a brief introduction of Diels-Alder reactions and masked o-benzoquinones and contains the results and discussion along with the experimental section of the novel domino retro-Diels-Alder (rDA) – Diels-Alder (DA) protocol applied to the masked o-benzoquinone chemistry for the synthesis of several bicyclo[2.2.2]octenones and bicyclo[2.2.2]octadienones. This procedure is focused on 3 main objectives: 1) utilization of a masked o-benzoquinone dimer which was a side product in the masked o-benzoquinone Diels-Alder

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29

Kau, Kuo-Chang, and 高國璋. "Synthesis of All-Conjugated Block Copolymers PPP-P3HT by Using Grignard Metathesis and Study of Copolymer Blending with C60 Derivatives PCBM/ICBA: Hybrid Morphology, Optoelectronic Property and Solar Cell Application." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/46786317120068140114.

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碩士<br>國立臺灣大學<br>化學工程學研究所<br>100<br>In this study, all-conjugated rod-rod poly(2,5-dihexyloxy-p-phenylene)- b-poly(3-hexylthiophene) (PPP-P3HT) block copolymers with different block ratio between PPP and P3HT were synthesized and their self-assembly behavior was investigated. A series of monodisperse PPP-P3HT block copolymers consisting of a nearly constant molecular weight PPP block and a different molecular weight P3HT block was synthesized via a sequential Grignard metathesis method (GRIM). Gel permeation chromatographer, NMR spectra and transmission electron microscopy were used to characte

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