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Dissertations / Theses on the topic 'PPAR gamma'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Olson, Peter. "PPAR gamma and PPAR delta in glucose and lipid homoeostasis /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3153704.

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2

Michel, Ursula. "Assoziation der Variante Pro115Gln im PPAR[gamma]2-Gen [PPAR-gamma-2-Gen] mit Adipositas und Diabetes mellitus Typ II." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969118597.

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3

Shiau, Chung-Wai. "Thiazolidinediones: from peroxisome-proliferator-activated receptor [gamma] (PPAR[gamma]) to anticancer agents." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1128111032.

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4

Takahama, Carina Harumi. "Controle da Anexina 1 sobre a expressão do receptor nuclear proliferador de peroxissomos em diferentes tipos celulares." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-26092016-125014/.

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A proteína Anexina A1 (ANXA1), sintetizada e liberada por fagócitos pela ação de glicocorticóides, é uma proteína anti-inflamatória, pois inibe o influxo de neutrófilos para o foco da inflamação, e induz os mecanismos de eferocitose em neutrófilos e macrófagos. Nosso grupo mostrou que a ANXA1 regula a expressão do receptor ativado por proliferadores de peroxissomos (PPAR) em macrófagos. Em continuidade, o presente trabalho investigou o mecanismo da ANXA1 sobre a expressão de PPARγ em macrófagos, e se este controle ocorre em demais leucócitos e tecido adiposo. Para tanto, macrófagos, neutr

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Gomes, Emerson Rodrigo Machi 1977. "Caracterização bioquímica e celular da glutaminase isoforma Kidney-type com seus parceiros de interação." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311950.

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Orientador: Sandra Martha Gomes Dias<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-23T00:13:51Z (GMT). No. of bitstreams: 1 Gomes_EmersonRodrigoMachi_M.pdf: 4424058 bytes, checksum: 4547741a163b53b4836c32f103096cd3 (MD5) Previous issue date: 2013<br>Resumo: Células tumorais apresentam uma autonomia metabólica aumentada em comparação a células não-transformadas, incorporando nutrientes e metabolizando-os através de vias que suportam o seu crescimento e proliferação. O foco deste trabalho foi a enzima glutami

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6

Tremblay, Hugo. "Identification et caractérisation d'agonistes mixtes des récepteurs GPR40 et PPAR[gamma]." Mémoire, Université de Sherbrooke, 2011. http://savoirs.usherbrooke.ca/handle/11143/4930.

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Le diabète de type II est une maladie impliquant deux déficiences majeures : la résistance à l'insuline et la diminution de sécrétion d'insuline. Afin d'identifier de nouvelles pistes de traitement potentiel pour cette maladie nous avons utilisé une approche polypharmacologique ciblant simultanément ces deux déficiences. Pour ce faire nous avons conçu et synthétisé une librairie de 29 composés et caractérisé leur activité biologique sur les récepteurs GPR40 et PPAR[gamma], dans le but d'identifier des agonistes mixtes. Ce travail a mené l'identification de deux composés ayant une activité sur

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7

Kim, Dasom. "PPAR-gamma Regulates T Cell Responses in Air Pollutant-associated Inflammation." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1522414820700163.

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8

Evans, Kyle William. "PPAR gamma AND eNOS CONTRIBUTE TO THE RESOLUTION OF CHRONIC INFLAMMATION." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/197871.

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Microbiology and Immunology<br>Ph.D.<br>Chronic inflammation follows defined phases of induction, inflammation, and resolution. The resolution phase requires cycloxygenase-2 (COX-2) activity. This study aims to address what other molecules are required for a functional resolution phase. We demonstrated that in murine collagen-induced arthritis the transcription factor, PPARgamma plays a role in the resolution phase. Inhibition of COX-2 activity results in fewer PPARgamma positive cells in the arthritic synovium. Treatment with a PPARgamma antagonist, SR202, alone, also disrupts the process of

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Baker, Amelia Rachel Haas. "Environmental PPAR-gamma agonists accelerate aging of bone and impair lymphopoiesis." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12274.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>A growing number of environmental contaminants, including phthalates and organotins, are being recognized for their ability to activate peroxisome proliferator-activated receptor γ (PPARγ) and promote adipogene

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Beuzelin, Diane. "Rôle des récepteurs nucléaires PPAR gamma et PPAR alpha dans la conversion d'adipocytes blancs humains en adipocytes bruns/brites." Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30346/document.

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Chez les mammifères, deux types de tissu adipeux (TA) sont présents: le TA blanc, qui est l'organe de stockage et de libération des lipides, et le TA brun, qui est un organe spécialisé dans la production de chaleur grâce à l'expression de la protéine découplante mitochondriale UCP1.Chez l'homme, la présence d'un TA brun métaboliquement actif est inversement corrélée à l'obésité et au diabète de type 2. Ce TA brun est composé de deux types distincts de cellules thermogéniques, les adipocytes bruns classiques présents dans des dépôts spécifiques et les adipocytes "brite " (brown-in-white). Chez

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Whittall, Christine Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Interaction between N-(3-oxododecanoyl)-L-homoserine lactone and peroxisome proliferator-activated receptor gamma." Awarded By:University of New South Wales. Biotechnology & Biomolecular Sciences, 2009. http://handle.unsw.edu.au/1959.4/44957.

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Pseudomonas aeruginosa is a significant pathogen of immunocompromised individuals, and the main mechanism by which it mediates virulence is through the coordination of gene expression by an intricate quorum sensing system. One of the signalling molecules of this system, N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) has been shown to have immunomodulatory capabilities, discrete to its quorum sensing role. While the general focus of research in this area is on the physiological outcomes of this interaction on cell function, there is currently little concrete evidence identifying the receptor

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Schupp, Michael. "Identifizierung und Charakterisierung von AT1-Antagonisten als PPAR[gamma]-Liganden [PPARgamma-Liganden]." [S.l.] : [s.n.], 2005. http://www.diss.fu-berlin.de/2005/134/index.html.

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Oliveira, Thiago Belchior de. "Envolvimento dos PPARγ nas ações metabólicas dos ácidos graxos ômega-3." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-18042016-090407/.

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O consumo de ácidos graxos n-3 tem sido associado à proteção contra a obesidade, inflamação e resistência à insulina. Os n-3 são ligantes fracos dos receptores nucleares PPARγ, e pela ativação deste podem exercer suas ações metabólicas e anti-inflamatórias. No presente trabalho, foi investigado se o aumento da disponibilidade dos n-3 geneticamente ou por dieta, via ativação de PPARγ, protege camundongos do desenvolvimento da obesidade, intolerância a glicose e inflamação do tecido adiposo. Foi visto em um modelo com camundongos fat-1 (elevados níveis endógenos de n-3) que dentre as

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Goyal, Girija. "Novel Role of PPAR-Gamma in GM-CSF Induced Anti-Tumor Immunity." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226102.

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Granulocyte macrophage colony stimulating factor (GM-CSF) mediates context dependent anti- or pro-inflammatory functions through cells of the myeloid lineage. GM-CSF signaling induces the expression of the transcription factor peroxisome proliferator-activated receptor gamma (PPAR-γ). We examined the role PPAR-γ in myeloid cells in the anti-tumor response to GVAX, a GM-CSF based cancer immunotherapy using the B16 model of murine melanoma. We found that selective loss of PPAR-γ in the myeloid lineage using LysM-Cre reduces the efficacy of GVAX which could not be explained by known mechanisms.

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Mottin, Melina 1981. "Simulações de dinâmica molecular do receptor ativador da proliferação de peroxissomos y com o agonista parcial GQ16." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248855.

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Orientador: Munir Salomão Skaf<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-20T04:47:12Z (GMT). No. of bitstreams: 1 Mottin_Melina_M.pdf: 3350054 bytes, checksum: 28a03021273db312bbcba2e77fe7b2eb (MD5) Previous issue date: 2012<br>Resumo: O Receptor Ativador da Proliferação de Peroxissomos g (PPARg) e membro de uma família de receptores nucleares cuja atividade é regulada por ligantes. O PPARg atua no metabolismo de lipídios e promove a sensibilização sistêmica à insulina, sendo, portanto, um alvo em potencial para

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Rodway, Helen Anne. "A ligand of peroxisome-proliferator activated receptor #gamma# (PPAR#gamm#), has potential in the treatment of neuroblastoma." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395902.

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Valenzuela, Bassi Rodrigo Andrés. "Regulación de la autofagia del cardiomiocito por ligandos farmacológicos del receptor activado por proliferadores peroxisomales gama (PPARγ)". Tesis, Universidad de Chile, 2011. http://repositorio.uchile.cl/handle/2250/105221.

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Doctor en Farmacología<br>Diversos estudios clínicos han revelado que las tiazolidinedionas, fármacos para el tratamiento de la diabetes de tipo 2 y resistencia a insulina, podrían reducir la morbimortalidad cardiovascular. Su mecanismo de acción es a través de la activación de los Receptores Activados por Proliferadores Peroxisomales (PPARs), los cuales son factores transcripcionales activados por ligandos. En el sistema cardiovascular, los PPARs se expresan de forma variable y juegan un importante papel en la regulación del metabolismo energético y en la respuesta inflamatoria. Durant

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Jacouton, Elsa. "Etude de la modulation de voies métaboliques par une sélection de bactéries lactiques et bifidobactéries dans la cellule épithéliale intestinale humaine : détermination des effets physiologiques induits par la bactérie Lactobacillus rhamnosus CNCMI - 4317 dans un modèle murin axénique." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066169.

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Au cours des dix dernières années, il a été observé une augmentation des maladies métaboliques (obésité, diabète de type 2…) avec des conséquences dramatiques en santé humaine. Un intérêt scientifique a émergé pour mieux comprendre comment les bactéries lactiques (BLs) régulent la l’équilibre énergétique de leur hôte. PPAR- (peroxisome proliferator activated receptor ), un récepteur nucléaire, et FIAF (fasting – induced adipose factor) une adipokine apparaissent comme deux régulateurs centraux dans l’homéostasie énergétique. Dans cette étude, nous avons examiné les mécanismes de régulation d

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Pelham, Christopher James. "Novel mechanisms of vascular-specific peroxisome proliferator-activated receptor gamma in hypertension and atherosclerosis." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/2604.

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The nuclear hormone receptor peroxisome proliferator-activated receptor Γ (PPARΓ) is a ligand-dependent transcription factor of increasing importance in cardiovascular physiology. Treatment of type II diabetes patients with thiazolidinediones (TZD), synthetic ligands of PPARΓ, improves insulin sensitivity and also lowers blood pressure despite increased water and salt retention by the kidneys. In 1999, Stephen O'Rahilly's group reported that patients carrying mutations in PPARΓ exhibit severe type II diabetes and early-ons

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Puhl, Ana Cristina. "Caracterização de agonistas do PPARγ através de ensaios celulares e biologia estrutural." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-07122012-091615/.

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Os receptores nucleares são uma família de fatores de transcrição que regulam a transcrição gênica em resposta a ligantes e estão envolvidos em vários processos fisiológicos e metabólicos do organismo. O receptor ativado por proliferadores peroxissomais γ (PPARγ) está envolvido em vários processos fisiológicos incluindo adipogênese, homeostase da glicose, metabolismo de lipídios e inflamação e foi identificado como alvo molecular para o tratamento do diabetes tipo II. A importância desse receptor ficou ainda mais evidente pela descoberta de mutações que prejudicam sua função, causa

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21

Guo, Guanlun. "Stereo-selective binding of enantiomeric ligands in PPAR[gamma] : a molecular modeling study." HKBU Institutional Repository, 2013. http://repository.hkbu.edu.hk/etd_ra/1516.

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22

Woll, Addison Wayne. "Role of PPAR[gamma] and retinol binding protein 7 in the vascular endothelium." Thesis, University of Iowa, 2017. https://ir.uiowa.edu/etd/6013.

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Peroxisome Proliferator-Activated Receptors (PPARs) are a family of conserved ligand activated nuclear receptor transcription factors heterogeneously expressed in mammalian tissues. PPARγ is recognized as a master regulator of adipogenesis, fatty acid metabolism, and glucose homeostasis, but genetic evidence also supports the concept that PPARγ regulates the cardiovascular system, particularly vascular function and blood pressure. There is now compelling evidence that the beneficial blood pressure lowering effects of PPARγ activation are due to its activity in vascular smooth muscle and endoth

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23

Zhu, Jaja. "Perspectives thérapeutiques de la modulation de PPAR-gamma dans les leucémies aiguës myéloïdes." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASL114.

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La leucémie aiguë myéloïde (LAM) représente la forme la plus fréquente de leucémie aiguë chez l'adulte. Le pronostic global des LAM reste souvent médiocre en raison de la fréquence élevée des rechutes, causées par la persistance des cellules souches leucémiques (CSL) peu ou insensibles à la chimiothérapie conventionnelle. L'activation de PPAR-gamma implique la diminution transcriptionnelle de STAT5A/B, deux facteurs de transcription essentiels à la maintenance des CSL. Cette modulation du niveau de STAT5 constitue un mécanisme d'action potentiel des agonistes de PPAR-gamma dans les LAM, car la

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Lavallée-Bourget, Marie-Hélène. "Rôle de la phosphorylation sur tyrosine dans la régulation de l'activité de PPARγ". Master's thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/33285.

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Tableau d'honneur de la Faculté des études supérieures et postdoctorales, 2016-2017.<br>L’obésité et ses complications telles le diabète et la stéatose hépatique non alcoolique sont des enjeux de santé qui prennent de plus en plus d’ampleur partout sur la planète et la compréhension approfondie des mécanismes physiopathologiques impliqués est essentielle pour mieux contrer ces maladies. La protéine peroxisome proliferator activated receptor gamma (PPARγ) est reconnue pour ses propriétés antiinflammatoires, insulino-sensibilisantes et pro-adipogéniques. Des résultats antérieurs ont démontré qu’

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Coimbra, Cassio Negro. "Efeito da pioglitazona sobre a viabilidade funcional e o índice de apoptose de ilhotas pancreáticas murídeas em cultura." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-13102008-115420/.

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Acredita-se que a diminuição progressiva da massa de células observada durante a evolução do diabetes mellitus tipo 2 (DM 2) ocorra por apoptose deste tipo celular. As tiazolidinedionas (TZDs), uma classe de medicamentos utilizada no tratamento do DM 2, atuam como ligantes dos receptores ativados por proliferadores de peroxissomos (PPAR) e e promovem diminuição da resistência periférica à insulina. Embora existam estudos controversos, tem se especulado que as TZDs possam exercer efeitos diretos sobre as células pancreáticas, prevenindo a perda por apoptose e melhorando a sua viabilidade. O

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Burke, Rita Velikina. "The associations between diet, flavonoids, polymorphisms of the PPAR-gamma, PPAR-delta, and CRP genes and lung and upper aerodigestive tract (UADT) cancers." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1779690481&sid=3&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Lagane, Céline. "Rôle de l'IL-13 et des ligands de PPAR-gamma dans la réponse anti-infectieuse des macrophages murins et des monocytes humains vis-à-vis de Candida Albicans : implication de PPAR-gamma." Toulouse 3, 2007. http://thesesups.ups-tlse.fr/57/.

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Candida albicans est le champignon pathogène le plus commun chez l'homme. Il est la cause de candidoses gastro-intestinales, infections opportunistes qui touchent essentiellement les patients immunodéprimés. L'induction d'une immunité à médiation cellulaire contre C. Albicans plus particulièrement par les cellules du système immunitaire inné joue un rôle critique dans la défense de l'hôte. Nous avons démontré précédemment in vitro sur des macrophages péritonéaux de souris que les cytokines Th2, et notamment l'IL-13, peuvent activer les fonctions effectrices de ces cellules qui sont impliquées

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Batatinha, Helena Angelica Pereira. "Exercício aeróbio crônico reduz o acúmulo de gordura hepático, mas promove inflamação no fígado de camundongos PPAR-alpha knockout, via inibição do PPAR-gama." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-08122015-185802/.

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A NAFLD é uma das principais patologias de fígado. Estudos reportam o exercício físico como um dos principais alvos terapêuticos para esta doença. Verificamos se o treinamento melhora a resistência à insulina, inflamação e esteatose hepática causados pela dieta hiperlipídica (HF) e se o PPAR-alpha está envolvido neste processo. Animais selvagens C57BL6 (WT) e knockout para PPARα (KO) foram alimentados com dieta padrão ou HF durante 12 semanas e treinados por 8 semana. Metade dos animais KO treinados receberam rosiglitazona. A dieta HF aumentou TAG hepático, e resistência periférica à ins

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Oxer, Daniella Stefani. "Interação entre as vias de sinalização CD40/CD40L e os PPARs." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5159/tde-17062009-122735/.

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O receptor CD40 e seu ligante CD40L possuem um papel importante na interface entre a resposta imune inata e a adaptativa. Disfunções desta via de sinalização são descritas em doenças de origem inflamatória e autoimunes. Em Lúpus eritematoso sistêmico (LES) foi descrito um aumento nos níveis séricos de CD40L solúvel, que participa na produção de autoanticorpos. Receptores ativados por proliferadores de peroxisomos (PPARs) são fatores de transcrição que inicialmente foram descritos como envolvidos apenas no metabolismo lipídico, mas que atualmente são também descritos como atuantes no controle d

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Stump, Madeliene. "The role of brain PPAR[gamma] in regulation of energy balance and glucose homeostasis." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/6000.

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The Peroxisome Proliferator-Activated Receptor gamma (PPARγ), a master regulator of adipogenesis, has been shown to influence energy balance through its actions in the brain rather than in the adipose tissue alone. Deletion of PPARγ in mouse brain results in resistance to weight gain in response to high fat diet. Activation of PPARγ leads to change in the firing pattern of melanocortin system neurons (POMC and AgRP), which are critical for energy homeostasis. To determine the effects of modulation of brain PPARγ on food intake and energy expenditure we generated a novel transgenic mouse model

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Griggs, Ryan B. "TARGETING METHYLGLYOXAL AND PPAR GAMMA TO ALLEVIATE NEUROPATHIC PAIN ASSOCIATED WITH TYPE 2 DIABETES." UKnowledge, 2015. https://uknowledge.uky.edu/physiology_etds/24.

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Neuropathic pain affects up to 50% of the 29 million diabetic patients in the United States. Neuropathic pain in diabetes manifests as a disease of the peripheral and central nervous systems. The prevalence of type 2 diabetes is far greater than type 1 (90%), yet the overwhelming focus on type 1 models this has left the mechanisms of pain in type 2 diabetes largely unknown. Therefore I aimed to improve the current mechanistic understanding of pain associated with type 2 diabetes using two preclinical rodent models: Zucker Diabetic Fatty rats and db/db mice. In addition, I highlight the transla

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Blanchard, Pierre-Gilles. "Déterminants du contrôle de l'entreposage des lipides dans le tissu adipeux par le récepteur nucléaire PPARy." Thesis, Université Laval, 2012. http://www.theses.ulaval.ca/2012/29433/29433.pdf.

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Lefebvre, Anne-Marie. "Role des activateurs du recepteur active par les proliferateurs des peroxysomes gamma (ppar gamma) dans les metabolismes lies au tissu a dipeux et au colon (doctorat : sciences pharmaceutiques)." Lille 2, 1998. http://www.theses.fr/1998LIL2P263.

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Dewar, Brian J. Graves Lee M. "PPAR[gamma]-independent mechanisms of Src kinase activation and EGFR transactivation in response to thiazolidinediones." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1222.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum in Toxicology." Discipline: Toxicology; Department/School: Medicine. On title page, [gamma] appears as Greek character.

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Moulin, David. "Identification de cibles pharmacologiques des agonistes de PPAR gamma responsables de leurs potentialités anti-arthritiques." Nancy 1, 2005. http://www.theses.fr/2005NAN11318.

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Les récepteurs activés par les proliférateurs de péroxysomes sont des récepteurs nucléaires dont le rôle a été largement mis en évidence dans le métabolisme lipidique et l'homéostasie du glucose. Récemment, des activateurs de l'isotype PPARγ ont démontré des potentialités inflammatoires intéressantes dans des modèles expérimentaux d'arthrite. Deux stratégies thérapeutiques complémentaires visant à contrôler l'inflammation dans les maladies articulaires, telles que la Polyarthrite Rhumatoïde (PR), peuvent être envisagées : la plus classique est de s'opposer à l'expression et/ou à l'action des c

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Carter, Jennifer C. Church Frank C. "PPAR-[gamma] ligands and adipocytes regulate expression of the plasminogen activator system in breast cancer." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2434.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Sep. 3, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pathology and Laboratory Medicine." Discipline: Pathology and Laboratory Medicine; Department/School: Medicine. On title page, [gamma] appears as Greek character.

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Welch, John Sutton. "Studies in macrophage gene expression : PPAR[gamma], interleukin-4 and implications of post-genomic science /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2002. http://wwwlib.umi.com/cr/ucsd/fullcit?p3055803.

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Campi, I. "DESCRIZIONE DI UN CASO DI SEVERA INSULINO-RESISTENZA E LIPODISTROFIA PARZIALE, CAUSATO DA UNA MUTAZIONE A CARICO DEL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA (PPAR-GAMMA): CARATTERIZZAZIONE CLINICA E MOLECOLARE." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/217628.

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Mutations affecting ligand or DNA binding functions of PPARγ are associated with lipodystrophic insulin resistance. In the present study, we describe a 31 yr old female, heterozygous for a novel, mutation of PPARγ. Clinical features included hirsutism, polycystic ovarian syndrome, dyslipidaemia and hypertension. Hyperinsulinaemia during an OGTT and HOMA-IR 11.1% confirmed severe insulin resistance. She had distal limb and gluteal lipodystrophy with reduced subcutaneous adipose tissue (SCAT) but preserved visceral adipose tissue (VAT), with SCAT/VAT ratio of 0.619 (NR 0.19±0.084) and hepatic

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Dingels, Nicole Katherine. "Oxidized soybean oil alters the expression of PPAR gamma and target genes in 3T3-L1 cells." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/nutrition_theses/40.

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Background: The typical western diet contains foods with modest amounts of lipid oxidation products. Previous work by us and others have demonstrated that mildly oxidized lipids promote a gain in fat mass while highly oxidized lipids decrease fat mass in rodents and triglyceride (TAG) accumulation in 3T3-L1 cells. Adipocyte differentiation is regulated by a key nuclear transcription factor known as PPARγ. Objective: To investigate if the alterations in triglyceride accumulation in 3T3-L1 cells pretreated with oxidized soy oil are due to 1) a change in PPARg DNA interactions 2) changes in the

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Nugent, Claire. "Effects of free fatty acids and PPAR[gamma] agonists on glucose uptake in 3T3-L1 adipocytes." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619886.

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Pavlicek, Valérie [Verfasser], and Ulrich [Akademischer Betreuer] Laufs. "Regulation endothelialer Progenitorzellen durch den dualen PPAR-alpha/gamma-Agonisten Aleglitazar / Valérie Pavlicek. Betreuer: Ulrich Laufs." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2015. http://d-nb.info/1069289957/34.

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Skinner, Joanna P. "Determination of Oxidized Lipids in Commonly Consumed Foods and Their Binding Affinity for PPARγ". Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/nutrition_theses/32.

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Background: Foods rich in polyunsaturated fatty acids (PUFA) are susceptible to oxidation through heating or storage. Oxidized lipids are known to act as ligands for a transcription factor (PPAR-gamma) that affects adipocyte differentiation and insulin sensitivity. Objective: The purpose of this study was to determine the amounts of oxidation products of a variety of PUFA containing foods over time, and to determine whether extracted fats from these foods act as ligands for PPAR-gamma. Method: To study the effect of room-temperature storage on oxidation, 5 foods (walnuts, sunflower seeds,

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Emond, Audrey. "Étude du rôle du general receptor for phosphoinositides 1 (GRP1) dans l'adipogenèse." Mémoire, Université de Sherbrooke, 2011. http://savoirs.usherbrooke.ca/handle/11143/4075.

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Many studies have shown that peroxisome-proliferator-activated receptor [gamma] (PPAR[gamma]) plays an important role in adipose tissue formation by activating genes implicated in adipogenesis. PPAR[gamma] heterodimerizes with retinoid X receptor [alpha] (RXR[alpha]), in the presence of ligand, on PPAR response elements (PPREs) in the promoter of target genes involved in adipocyte differentiation. General receptor for phosphoinositides 1 (GRP1) is a corepressor of thyroid hormone receptors (TRs), a nuclear receptor like PPAR[gamma]. GRP1 decreases TRs' transcriptional activity by lowering dime

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Ait, Benichou Siham. "Étude de la régulation des canaux potassiques ROMK1 par un antidiabétique, la rosiglitazone implication des PPARgamma." Mémoire, Université de Sherbrooke, 2011. http://savoirs.usherbrooke.ca/handle/11143/4079.

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Les thiazolidinediones (TZDs) sont des médicaments antidiabétiques (agonistes des récepteurs nucléaires de type PPAR[gamma]) utilisés au cours des dix dernières années pour le traitement du diabète de type II. Malheureusement leur utilisation peut provoquer, chez certains patients, une rétention accrue de fluides et une formation d?oedèmes rénaux. Des études récentes suggèrent l'implication d'un canal sodique épithélial (ENaC), exprimé au niveau du tubule collecteur rénal, dans ces effets secondaires. En effet, la stimulation des PPAR[gamma] par les TZDs activent les canaux sodiques épithéliau

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Fournier, Carole. "Le strontium comme inhibiteur de l'adipogenèse et modulateur du statut redox des cellules souches mésenchymateuses." Thesis, Saint-Etienne, 2011. http://www.theses.fr/2011STET004T.

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L’ostéoporose liée à l’âge se caractérise par une perte osseuse et une augmentation de l’adiposité médullaire tout en s’accompagnant d’un stress oxydant général. L’ostéoblaste et l’adipocyte ont un précurseur commun, la cellule souche mésenchymateuse (CSM), dont la capacité à se renouveler et à se différencier est influencée par le statut redox cellulaire. Le Strontium (Sr) est un élément possédant un effet antifracturaire significatif in vivo cependant, il n’affecte que peu les marqueurs d’activités des cellules osseuses différenciées. Partant de ce constat, nous avons émis l’hypothèse que le

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Ji, Shengbo [Verfasser]. "Effects of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists and physical activity on long-term stroke outcome in a mouse model / Shengbo Ji." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2010. http://d-nb.info/1024006344/34.

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Berthiaume, Magalie. "Contribution des glucocorticoïdes aux mécanismes d'action des récepteurs PPAR[gamma] et leur implication dans le métabolisme lipidique." Doctoral thesis, Université Laval, 2007. http://hdl.handle.net/20.500.11794/18891.

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Meyer, Maxime. "Conception et synthèse de nouvelles molécules bioactives duales : vers des composés antagonistes AT1 et agonistes PPAR[gamma]." Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0221.

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Certains antagonistes du récepteur AT1 (« angiotensin II type 1 receptors ») utilisés dans le traitement de l'hypertension artérielle ont par la suite également montré une activité au niveau de PPAR[gamma] (« Peroxisome Proliferator Activated Receptor [gamma] »), un récepteur impliqué dans la régulation du métabolisme du glucose. Cela constitue une nouvelle approche thérapeutique vers un traitement concomitant de l'hypertension artérielle et du diabète de type II, qui sont souvent associés. Dans ce contexte, nous nous sommes dirigés vers la conception rationnelle de molécules capables d'intera

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Colin-Cassin, Christelle. "Activité PPARgamma-indépendante des ligands de PPAR gamma : une piste pour le traitement des cancers du sein ?" Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0232/document.

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L'un des enjeux majeurs de la recherche anti-cancéreuse est de développer de nouvelles thérapies en direction des tumeurs réfractaires aux traitements conventionnels. Dans ce contexte, l'identification récente de l'activité anti-tumorale PPARgamma-indépendante des thiazolidinediones ouvre de nouvelles perspectives thérapeutiques. Au sein du laboratoire, il a été montré qu'un analogue inactif de la TGZ, la delta2-TGZ, induit une dégradation protéasome-dépendante du récepteur alpha aux oestrogènes de manière PPARgamma-indépendante. A partir de ces données, les objectifs de ma thèse ont été 1) de

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Chbicheb, Sarra. "Etude du facteur de transcription précoce EGR1 dans l'effet antiprolifératif des ligands de PPAR[gamma] sur les cellules cancéreuses mammaires." Thesis, Nancy 1, 2011. http://www.theses.fr/2011NAN10039.

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Les ligands des récepteurs nucléaires PPAR[gamma] (15-deoxy-[delta]12,14-Prostaglandine J2 (15d-PGJ2) et les thiazolidinediones (TZDs) : troglitazone (TGZ), ciglitazone (CGZ)) exercent un effet antiprolifératif sur les lignées cancéreuses mammaires. Plusieurs études suggèrent que les effets anticancéreux sont liés à des effets PPAR[gamma]-indépendants. Notre travail s?inscrit dans la compréhension de tels mécanismes d?action. Notre étude a montré une induction du facteur de transcription EGR1 (Early Growth Response gene 1) par certains ligands de PPAR[gamma] (TGZ, CGZ, 15d-PGJ2 et [delta]2-TGZ

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