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Chen, L. M., S. D. Yamada, Y. S. Fu, R. L. Baldwin, and B. Y. Karlan. "Molecular similarities between primary peritoneal and primary ovarian carcinomas." International Journal of Gynecologic Cancer 13, no. 6 (2003): 749–55. http://dx.doi.org/10.1136/ijgc-00009577-200311000-00004.
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The objective of this paper was to characterize expression patterns of biologic markers to distinguish papillary serous peritoneal carcinoma (PPC) from papillary serous ovarian carcinoma (POC). Immunohistochemical analysis of HER-2/neu, p53, bcl-2, and nm23-H1 expression was performed on archival paraffin-embedded tissues. Antigen expression was compared at ovarian and extra-ovarian sites. Thirty-two PPC cases were compared to 18 POC cases. Mean age, stage, grade, and survival outcome were comparable between the two groups. Antigen expression patterns were not significantly different between PPC and POC for the four markers studied. In all cases, nm23-H1 was expressed. Conversely, bcl-2 was expressed at only a single tissue site in three of 32 (9.4%) PPC cases and in one of 18 (5.6%) POC cases. Eleven of 32 (34.4%) PPC cases overexpressed HER-2/neu, vs. four of 18 (22.2%) POC cases. P53 staining results were positive in 23 of 32 (71.9%) PPC and 13 of 18 (72.2%) POC cases. Intrapatient antigen expression was identical at primary and metastatic tumor sites in 50% of the POC and 48.4% of the PPC cases. We conclude that PPC and POC have a comparable immunohistochemical phenotype for these four molecular markers, which is reflected by their similar clinical courses.
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Okada, Takayuki, Hajime Otani, Yue Wu, Takamichi Uchiyama, Shiori Kyoi, Reiji Hattori, Tomohiko Sumida, Hiroyoshi Fujiwara, and Hiroji Imamura. "Integrated pharmacological preconditioning and memory of cardioprotection: role of protein kinase C and phosphatidylinositol 3-kinase." American Journal of Physiology-Heart and Circulatory Physiology 289, no. 2 (August 2005): H761—H767. http://dx.doi.org/10.1152/ajpheart.00012.2005.
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Although protein kinase C (PKC) and phosphatidylinositol 3 (PI3)-kinase are implicated in cardioprotective signal transduction mediated by ischemic preconditioning, their role in pharmacological preconditioning (PPC) has not been determined. Cultured neonatal rat cardiomyocytes (CMCs) were subjected to simulated ischemia for 2 h followed by 15 min of reoxygenation. PPC of CMCs consisted of administration of 50 μM adenosine, 50 μM diazoxide, and 50 μM S-nitroso- N-acetylpenicillamine (SNAP), each alone or in combination, for 15 min followed by 30 min of washout before simulated ischemia. Although PKC-ε and PI3-kinase were significantly activated during treatment with adenosine, activation of these kinases dissipated after washout. In contrast, PPC combined with adenosine, diazoxide, and SNAP elicited sustained activation of PKC-ε and PI-3 kinase after washout. The combined-PPC, but not the single-PPC, protocol conferred antiapoptotic and antinecrotic effects after reoxygenation. The PKC inhibitor chelerythrine (5 μM) or the PI3-kinase inhibitor LY-294002 (10 μM) given during the washout period partially blocked the activation of PKC-ε and PI3-kinase mediated by the combined-PPC protocol, whereas combined addition of chelerythrine and LY-294002 completely inhibited activation of PKC-ε and PI3-kinase. Chelerythrine or LY-294002 partially blocked antiapoptotic and antinecrotic effects mediated by the combined-PPC protocol, whereas combined addition of chelerythrine and LY-294002 completely abrogated antiapoptotic and antinecrotic effects. These results suggest that the combined-PPC protocol confers cardioprotective memory through sustained and interdependent activation of PKC and PI3-kinase.
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Stepniewska, Iwona, Omar A. Gharbawie, Mark J. Burish, and Jon H. Kaas. "Effects of muscimol inactivations of functional domains in motor, premotor, and posterior parietal cortex on complex movements evoked by electrical stimulation." Journal of Neurophysiology 111, no. 5 (March 1, 2014): 1100–1119. http://dx.doi.org/10.1152/jn.00491.2013.
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Parietal and frontal cortex are central to controlling forelimb movements. We previously showed that movements such as reach, grasp, and defense can be evoked from primary motor (M1), premotor (PMC), and posterior parietal (PPC) cortex when 500-ms trains of electrical pulses are delivered via microelectrodes. Stimulation sites that evoked a specific movement clustered into domains, which shared a topographic pattern in New World monkeys and prosimian galagos. Matched functional domains in parietal and frontal cortex were preferentially interconnected. We reasoned that matched functional domains form parallel networks involved in specific movements. To test the roles of domains in M1, PMC, and PPC, we systematically inactivated with muscimol domains in one region and determined if functional changes occurred in matching domains in other regions. The most common changes were higher current thresholds for stimulation-evoked movements and shorter, not fully developed, trajectories of movements. Inactivations of an M1 functional domain greatly reduced or abolished movements evoked from the matching domains in PMC or PPC, whereas movements evoked from nonmatching domains remained mostly unaffected. In contrast, inactivating PMC or PPC domains did not consistently abolish the ability to evoke movements from matching M1 domains. However, inactivation of PMC domains suppressed or altered the movements evoked from PPC domains. Thus movement sequences evoked from PMC depend on M1 and movement sequences evoked from PPC depend on both M1 and PMC. Overall, the results support the conclusion that PPC, PMC, and M1 are subdivided into functional domains that are hierarchically related within parallel networks.
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Okawa, Sumiyo, Hla Hla Win, Hannah H. Leslie, Keiko Nanishi, Akira Shibanuma, Phyu Phyu Aye, and Masamine Jimba. "Quality gap in maternal and newborn healthcare: a cross-sectional study in Myanmar." BMJ Global Health 4, no. 2 (March 2019): e001078. http://dx.doi.org/10.1136/bmjgh-2018-001078.
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IntroductionAccess to maternal and newborn healthcare has improved in Myanmar. However, regular contact with skilled care providers does not necessarily result in quality care. We assessed adequate contact made by women and newborns with skilled care providers, reception of high-quality care and quality-adjusted contacts during antenatal care (ANC), peripartum care (PPC) and postnatal care (PNC) in Myanmar.MethodsThis cross-sectional study was conducted in a predominantly urban township of Yangon and a predominantly rural township of Ayeyawady in March 2016. We collected data from 1500 women. We measured quality-adjusted contact, which refers to adequate contact with high-quality care, as follows: ≥4 ANC contacts and receiving 11–14 of 14 intervention items; facility-based delivery assisted by skilled care providers, receiving 7 of 7 PPC intervention items; and receiving the first PNC contact ≤24 hours postpartum and ≥2 additional contacts, and receiving 16–17 of 17 intervention items. Using multilevel logistic regression analysis with a random intercept at cluster level, we identified factors associated with adequate contact and high-quality ANC, PPC and PNC.ResultsThe percentage of crude adequate contact was 60.9% for ANC, 61.3% for PPC and 11.5% for PNC. However, the percentage of quality-adjusted contact was 14.6% for ANC, 15.2% for PPC and 3.6% for PNC. Adequate contact was associated with receiving high-quality care at ANC, PPC and PNC. Being a teenager, low educational level, multiparity and low level in the household wealth index were negatively associated with adequate contact with healthcare providers for ANC and PPC. Receiving a maternal and child health handbook was positively associated with adequate contact for ANC and PPC, and with receiving high-quality ANC, PPC and PNC.ConclusionWomen and newborns do not receive quality care during contact with skilled care providers in Myanmar. Continuity and quality of maternal and newborn care programmes must be improved.
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Drummond, John J. "The Intentional Structure of Emotions." History of Philosophy and Logical Analysis 16, no. 1 (April 5, 2013): 244–63. http://dx.doi.org/10.30965/26664275-01601011.
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This paper approaches the intentional structure of the emotions by considering three claims about that structure. The paper departs from the Brentanian and Husserlian ‘priority of presentation claim’ (PPC). The PPC comprises two theses: (1) intentional feelings and emotions are founded on presenting acts and (2) intentional feelings and emotions are directed specifically to the value-attributes of the presented objects. The paper then considers two challenges to this claim: the equiprimordial claim (EC) and the priority of feeling claim (PFC). The EC asserts that the presentational and affective dimensions of intentional feelings and emotions are equiprimordial. I respond to this challenge to the PPC by revising it, claiming instead that the founding relations exist between the presentational and affective senses (rather than the acts) in an experience whose presenting and affective aspects are equiprimordial. The PFC grants priority to the affective, a grant which presupposes the independence of the affective from the presentational. I argue that the PFC is mistaken, and that the revision of the PPC can handle the examples on which the PFC is based.
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Pytela, Oldřich. "A new classification of solvents based on chemometric empirical scale of parameters." Collection of Czechoslovak Chemical Communications 55, no. 3 (1990): 644–52. http://dx.doi.org/10.1135/cccc19900644.
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The paper presents a classification of 51 solvents based on clustering in three-dimensional space formed by the empirical scale of PAC, PBC, and PPC parameters designed for interpretation of solvent effect on a model with cross-terms. For the classification used are the clustering methods of the nearest neighbour, of the furthest neighbour, of average bond, and the centroid method. As a result, the solvents have been divided into 8 classes denoted as: I - nonpolar-inert solvents (aliphatic hydrocarbons), IIp - nonpolar-polarizable (aromatic hydrocarbons, tetrachloromethane, carbon disulphide), IIb - nonpolar-basic (ethers, triethylamine), IIIp - little polar-polarizable (aliphatic halogen derivatives, substituted benzenes with heteroatom-containing substituents), IIIb - little polar-basic (cyclic ethers, ketones, esters, pyridine), IVa - polar-aprotic (acetanhydride, dialkylamides, acetonitrile, nitromethane, dimethyl sulfoxide, sulfolane), IVp - polar-protic (alcohols, acetic acid), and V - exceptional solvents (water, formamide, glycol, hexamethylphosphoric triamide). The information content of the individual parameters used for the classification has been determined. The classification is based primarily on solvent polarity/acidity (PAC), less on polarity/basicity (PBC), and the least on polarity/polarizability (PPC). Causal relation between chemical structure of solvent and its effect on the process taking place therein has been established.
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Villaça, Marcelo Pinheiro, and Mario Mantovani. "Comportamento da pressão intracraniana, da perfusão cerebral e dos parâmetros hemodinâmicos durante a síndrome do compartimento abdominal em cães." Revista do Colégio Brasileiro de Cirurgiões 33, no. 4 (August 2006): 211–14. http://dx.doi.org/10.1590/s0100-69912006000400003.
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OBJETIVO: Estudar as alterações hemodinâmicas e as repercussões sobre o sistema nervoso central ocasionados pela síndrome do compartimento abdominal. MÉTODO: Utilizou-se cães sem raça definida submetidos à anestesia geral e monitorização das pressões arterial média(PAM), intracraniana(PIC), de perfusão cerebral(PPC), da artéria pulmonar(PAP) e venosa central(PVC), do débito cardíaco(DC) e da freqüência cardíaca(FC). Aumentou-se a pressão intra-abdominal(PIA) para níveis de 10,20,30 e 40cmH2O . Após atingir-se nível PIA=40cmH2O realizou-se a descompressão cirúrgica da cavidade abdominal. Em cada etapa realizou-se a medida dos parâmetros PIA, PIC, PAM, PPC, PVC e DC. RESULTADOS: Observou-se que o aumento da PIA causou as seguintes alterações fisiológicas: aumento progressivo da PIC; aumento da PAM até PIA=20cmH2O e diminuição progressiva da mesma após PIA= 40cmH2O; aumento da PPC até PIA=10cmH2O e diminuição progressiva da mesma após PIA= 30cmH2O; aumento progressivo da PVC; diminuição progressiva do DC após PIA= 30cmH2O; Após a descompressão da cavidade, notou-se o retorno da PIC, PAM, PPC, PVC e do DC para valores próximos aos dos iniciais (antes do aumento da PIA). CONCLUSÕES: Concluímos que o aumento da PIA provocou alterações nos sistemas cardiovascular e nervoso central, que foram revertidas após a descompressão cirúrgica da cavidade abdominal.
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Wang, Wen Lin, Yin Jing Wan, Xiao Yan Tang, and Bin Liang. "Pollutants-Producing and Pollutants-Discharge Coefficients of Nitrogen and Phosphorous in Rural Domestic Sources in Taihu Lake Basin, China." Advanced Materials Research 955-959 (June 2014): 1132–42. http://dx.doi.org/10.4028/www.scientific.net/amr.955-959.1132.
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Nine households of high, medium and low income level were selected as representative household of the Taihu Lake basin, China to study the measuring method of pollutant producing coefficient (PPC) and pollutant discharge coefficient (PDC) of rural domestic sewage and organic waste. Results showed that the income level had no significant influences on TN-/TP-PPC of rural domestic sewage but substantially affected the production and TN-/TP-PDC of domestic sewage, as well as the production and TN-/TP-PPC/PDC of organic waste, which corresponded with income such that high-income farmer households produced the most and the middle income produced lesser and the low income households produced the least amount. The utilization and treatment efficiency of toilet wastewater and the comprehensive utilization rate of organic wastes, particularly the rate of livestock were the primary influencing factors of domestic sewage and waste PDC. These factors were substantially affected by agricultural income level and septic tank type.
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Hazra, Aniket, Atri Panda, and Priyanshu Sarkar. "Posterior Parietal Cortex Dysfunction is Central to Working Memory Storage and Broad Cognitive Deficits in Schizophrenia." International Journal of Chemical and Environmental Sciences 3, no. 2 (January 3, 2022): 50–66. http://dx.doi.org/10.15864/ijcaes.3203.
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Working memory (WM) deficiencies in patients with schizophrenia (PSZ) are thought to be caused by PFC dysfunction, but few research have looked at non-manipulated measures of WM storage. Storage capacity is more closely tied to the posterior parietal cortex (PPC) than the frontal cortex (PFC) in neurotypical people, suggesting that impairments in WM storage capacity in schizophrenia that are associated with widespread cognitive deficits may be related to neuronal activity in the PPC. While receiving fMRI, 37 PSZ and 37 matched healthy control volunteers of both sexes conducted a change detection test with varied set sizes. The assignment was created to emphasis WM storage while requiring minimal top-down management. BOLD activity correlated with the number of items kept in WM (K), as determined by task performance at a particular set size, according to whole-brain analyses. Independent of set size, K values predicted BOLD activity in the PPC, including the superior and inferior parietal lobules, intraparietal sulcus, and middle occipital gyrus, across groups. In the left PPC, whole-brain interaction analysis revealed that PSZ had much less K-dependent signal modulation than healthy control participants, a finding that could not be explained by a smaller K value range. The slope between K and PPC activation accounted for 43.4 percent of the variations in broad cognitive performance across groups. These findings suggest that PPC dysfunction is linked to WM storage abnormalities in PSZ and may play a role in schizophrenia's widespread cognitive deficiencies.
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RUSSELL, SCOTT M. "A Rapid Method for Predicting the Potential Shelf Life of Fresh Broiler Chicken Carcasses." Journal of Food Protection 60, no. 2 (February 1, 1997): 148–52. http://dx.doi.org/10.4315/0362-028x-60.2.148.
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An experiment was conducted to determine if rapid enumeration of populations of Pseudomonas fluorescens by standard methods and by measuring capacitance could be used to predict the potential shelf life of fresh broiler chicken. Fifty whole ready-to-cook broiler chicken carcasses were obtained fresh from the chiller and separated into five groups (10 carcasses each) in three replicate trials. The first 10 carcasses were sampled by rinsing on day 0. Ten carcasses each were sampled by rinsing after holding for 3, 6, 9, or 12 days at 3°C. For each carcass, psychrotrophic plate counts (PPC), P. fluorescens plate counts (PFPC), P. fluorescens detection times (PFDT), and subjective odor evaluations (ODOR) were determined. PPC, PFPC, and ODOR on groups of carcasses significantly increased after 3 days of storage at 3°C and every day thereafter throughout the storage period. The log Pseudomonas fluorescens detection times (LPDT) significantly decreased throughout storage from 0 to 12 days, indicating a significant increase in bacterial populations. Significant linear and quadratic correlations, respectively, were observed between PPC and day of storage (DAY) (R2 = .86 and .84), PFPC and DAY (R2 = .85 and .89), LPDT and DAY (R2 = .86 and .85), ODOR and DAY (R2 = .73 and .86), PPC and ODOR (R2 = .80 and .72), PFPC and ODOR (R2 = .87 and .81), LPDT and ODOR (R2 = .85 and .77), and LPDT and PPC (R2 = .96 and .97). A significant linear correlation was observed between LPDT and PFPC (R2 = .93). Enumeration of P. fluorescens from fresh chicken at day of processing should be beneficial because (i) the potential shelf life of fresh chicken can be determined at day of processing; (ii) processing sanitation hygiene may be determined; and (iii) carcasses exposed to temperature abuse may be identified.
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Johnson, A., P. Phillips, D. Hocking, M. F. Tsan, and T. Ferro. "Protein kinase inhibitor prevents pulmonary edema in response to H2O2." American Journal of Physiology-Heart and Circulatory Physiology 256, no. 4 (April 1, 1989): H1012—H1022. http://dx.doi.org/10.1152/ajpheart.1989.256.4.h1012.
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We investigated the effect of H2O2 (92 microM) in isolated guinea pig lungs perfused with a buffered Ringer solution. Pulmonary arterial pressure (Ppa), pulmonary capillary pressure (Ppc), and change in lung weight (delta W) were recorded at 0 min and at 15, 30, and 60 min after the H2O2. The capillary filtration coefficient (Kfc) was measured at 0 and 30 min. The perfusion of H2O2 increased the Ppa, Ppc, delta W, and Kfc. The thromboxane synthetase inhibitor Dazoxiben, or the vasodilator papaverine, prevented the increases in Ppa and Ppc. The protein kinase C (PKC) inhibitor H7 [1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride] prevented the increases in Ppa, Ppc, delta W, and Kfc, whereas the inactive isoquinoline HA1004 [N-(2-guanidinoethyl)-5-isoquinolinesulfonamide hydrochloride] had little effect on the H2O2 response. H2O2 increased the number of stress fibers and disrupted the peripheral band of cultured confluent endothelial cells, changes that were prevented with pretreatment with H7. PKC may mediate the increases in vascular permeability and pulmonary edema that occur in response to H2O2.
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Ginting, Arusmalem. "Increasing the Compressive Strength of Concrete Using PPC." Journal of Physics: Conference Series 2394, no. 1 (December 1, 2022): 012021. http://dx.doi.org/10.1088/1742-6596/2394/1/012021.
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Abstract Cement factories in Indonesia rarely produce OPC due to the high cost of production and less environmentally friendly, so they prefer to produce PPC or PCC. Cement factories located in areas that are rich in natural pozzolan will prefer producing PPC. In general, there is an assumption that increasing the compressive strength of concrete using PPC is slow at the early age. Based on these assumptions, it is necessary to conduct research on increasing the compressive strength of concrete using PPC at an early age. The specimen used was a concrete cylinder, with 3 specimens for each variation. The compressive strength test of concrete is carried out at the ages of: 3, 7, 14, 21, and 28 days. From the research results obtained, compressive strength of concrete has increased with increasing age of the concrete. The increasing the compressive strength of concrete using PPC is comparable with concrete using OPC. The unit weight of concrete is almost the same for all ages of concrete.
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Celli, Bartolome R., and Gordon L. Snider. "Preventing PPC." Chest 88, no. 3 (September 1985): 481. http://dx.doi.org/10.1378/chest.88.3.481-a.
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O'Donohue, Walter J. "Preventing PPC." Chest 88, no. 3 (September 1985): 481–82. http://dx.doi.org/10.1378/chest.88.3.481-b.
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Warnecke, H. J., and H. Kuhnle. "Integration of CAPP and PPC — The PPC Part." CIRP Annals 41, no. 1 (1992): 15–18. http://dx.doi.org/10.1016/s0007-8506(07)61142-1.
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Sapbamrer, Ratana, Manoch Naksata, Surat Hongsibsong, Jiraporn Chittrakul, and Wilawan Chaiut. "Efficiency of Gum Rosin-Coated Personal Protective Clothing to Protect against Chlorpyrifos Exposure in Applicators." International Journal of Environmental Research and Public Health 19, no. 5 (February 23, 2022): 2594. http://dx.doi.org/10.3390/ijerph19052594.
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An ideal theoretical model for personal protective clothing (PPC) is to protect wearers from external workplace hazards while meeting certain ergonomic requirements. This study aims to compare the efficiency of different personal protective clothing in its protection against chlorpyrifos, including gum rosin-coated PPC, commercial PPC (Tychem® coverall), and everyday clothing, during application under field conditions. Perception of discomfort and physiological effects after wearing PPC were also investigated. Thirty-one applicators were invited and consented to participate in the study. The study established that the median percentage of chlorpyrifos protection efficiency was 90.7% for commercial PPC, 89.2% for gum rosin-coated PPC, and 76.5% for everyday PPC. When the protection efficiency was compared among the different types of PPC, the percentage protection efficiency of gum rosin-coated PPC was not significantly different from that of commercial PPC. The percentage protection efficiencies of commercial PPC and gum rosin-coated PPC were significantly higher than that of everyday PPC. The major characteristics of gum rosin-coated PPC were water-repellency, breathability, low cost, and ease of manufacture. Therefore, this study suggests that gum rosin-coated PPC is a reasonable alternative PPC for farmers, particularly in low and middle-low-income countries and tropical climates, to protect against pesticides while providing acceptable comfort.
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Johnson, A., D. C. Hocking, and T. J. Ferro. "Mechanisms of pulmonary edema induced by a diacylglycerol second messenger." American Journal of Physiology-Heart and Circulatory Physiology 258, no. 1 (January 1, 1990): H85—H91. http://dx.doi.org/10.1152/ajpheart.1990.258.1.h85.
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We investigated the effect of dioctanoylglycerol (DOG), a second messenger of protein kinase C (PKC) activation, in the absence and presence of neutrophils in isolated perfused guinea pig lung. DOG was given after a base-line isogravimetric steady-state period. Pulmonary capillary pressure (Ppc) and change in lung weight (delta W) were monitored at 15, 30, and 60 min. Capillary filtration coefficient (Kf,c, an index of vascular permeability) was measured during base-line period and at 30 min. DOG increased the Ppc and delta W at 30 and 60 min, and the Kfc at 30 min. Monooctanoylglycerol, a monoacylglycerol that does not activate PKC, had no effect on Ppc, Kf,c, and delta W. Pretreatment with two different PKC inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methyl piperazine or staurosporin, prevented the pulmonary response to DOG. With neutrophils present, DOG caused greater increases in delta W and the (wet-dry)-to-dry wt ratio compared with DOG group. Response to DOG+ neutrophils was due to oxygen radical production because it was prevented by pretreatment with catalase and because DOG increased superoxide release from neutrophils. PKC activation using DOG in the isolated lung results in pulmonary edema mediated by increases in capillary pressure and vascular permeability. Lung weight-gain response to DOG is greater in the presence of neutrophils. Response to DOG+ neutrophils is mediated by oxygen radicals.
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Ferreira, Angela Ribeiro. "A Prática de Ensino na formação do professor de História no Brasil." Revista História Hoje 3, no. 5 (September 19, 2014): 301. http://dx.doi.org/10.20949/rhhj.v3i5.123.
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O artigo apresenta um panorama sobre a organização da prática de ensino nas licenciaturas em História nas universidades públicas federais e estaduais brasileiras, a partir da educação comparada. A amostra é composta de 73 PPC (Projetos Pedagógicos de Curso), que correspondem a 96 cursos, em todas as regiões do país. Na amostra encontramos uma diversidade de abordagem e interpretação sobre o formato da Prática como Componente Curricular (PCC). Alguns cursos organizaram a Prática de Ensino em forma de disciplinas específicas, outros alocaram a carga horária com uma parte em disciplinas específicas e outra parte diluída na grade. Outros cursos diluíram as 400 horas nas disciplinas já existentes na grade ou fizeram uma mistura entre pesquisa como PCC, pedagógicas como PCC, carga horária diluída. Os PPC apresentam variedade também nas temáticas e preocupações abordadas.
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Pan, Li Sha, Nai Xu, Zheng Tian, Ling Bin Lu, Su Juan Pang, and Qiang Lin. "Preparation and Characterization of Poly(propylene carbonate)/Alkali Lignin Composite Sheets by Calendering Process." Advanced Materials Research 233-235 (May 2011): 1786–89. http://dx.doi.org/10.4028/www.scientific.net/amr.233-235.1786.
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PPC is a new biodegradable aliphatic polycarbonate with poor thermal stability and mechanical properties which is difficult to form sheets or films and so on. Through the addition of alkali lignin, thermal stability and mechanical properties of PPC was improved largely. PPC/ alkali lignin sheets could be prepared. DSC results showed that the thermal stability of PPC was improved by the introduction of alkali lignin. SEM showed good dispersion of alkali lignin particles into PPC matrix that resulted in good miscibility. Improved mechanical properties and thermal stability of PPC/ alkali lignin blends were attributed to stronger interfacial interaction of PPC and alkali lignin. These results indicate that blending PPC with alkali lignin is an efficient and convenient method to improve the properties of PPC.
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Araújo, Maria Luiza Barbosa, Cristina Cardoso de Araújo, Francione Charapa Alves, and Maria Márcia Melo de Castro Martins. "O Processo de Aprendizagem e Desenvolvimento à Luz da Psicologia Histórico-Cultural: contribuições à formação docente." Práticas Educativas, Memórias e Oralidades - Rev. Pemo 4 (December 30, 2022): e48656. http://dx.doi.org/10.47149/pemo.v4.e48656.
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Este estudo objetiva analisar as teorias que perpassam o Projeto Pedagógico do Curso - PPC de Licenciatura em Ciências Biológicas de uma universidade pública do Ceará, com ênfase na Psicologia Histórico-Cultural. A investigação é de natureza qualitativa, e teve como método a pesquisa documental. Para a coleta de dados, utilizou-se PPC, que foi analisado por meio da técnica de Análise de Conteúdo. Os resultados obtidos mostram que o PCC é entrelaçado por uma diversidade de teorias da aprendizagem e do desenvolvimento, o que gera uma multiplicidade de metodologias e de práticas avaliativas. Tendo em vista que o PPC é um documento que deve contribuir com a elevação da qualidade do curso, assim como com a formação dos futuros professores, ressalta-se a necessidade de teorias críticas como a Psicologia Histórico-Cultural, para fundamentar as práticas docentes dos formadores de professores nos cursos de licenciatura, em particular, nas Ciências Biológicas.
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RUSSELL, SCOTT M. "Capacitance Microbiology as a Means of Determining the Quantity of Spoilage Bacteria on Fish Fillets." Journal of Food Protection 61, no. 7 (July 1, 1998): 844–48. http://dx.doi.org/10.4315/0362-028x-61.7.844.
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An experiment was conducted to determine if a method for enumeration of Pseudomonas fluorescens in less than 11 h could be used to predict potential spoilage of fresh fish of four species. In each of three separate replications (Rep), five boneless fillets from each species of fish, including rainbow trout (RT), Atlantic salmon (AS), red grouper (RG), and tilapia (T) were obtained fresh from a retail outlet. For each species, six 25-g samples of fish flesh were asceptically removed from each fillet, placed into a polyethylene bag, and stored at 3°C for 0,1, 2, 3,4, or 5 days. After storage, samples were analyzed for psychrotrophic plate count (PPC), Pseudomonas fluorescens plate counts (PFPC), and P. fluorescens capacitance detection times (PDT) and subjectively evaluated for odor (ODOR). PPC gradually increased on all fish species as storage time increased. In most cases, PFPC decreased slightly and then progressively increased as storage time increased. In Reps 1 and 2, PDT decreased gradually (indicating an increase in bacteria); however, in Rep 3, PDT were erratic and difficult to interpret. Odor increased gradually throughout the storage period for all fish species. Linear correlations (R2 > 0.80) were observed between PPC and day of storage (DAY) for all fish species and Reps except for RT and RG in Rep 3. PFPC correlated (R2 > 0.70) to DAY for all fish except RT in Rep 3 and RG in Rep 2. PDT was negatively correlated to DAY for RT and T in Rep 1 and for all fish in Rep 2. Odor scores were highly correlated (R2 ≥ 0.84) to DAY for all fish tested. PPC and PDT were negatively correlated for RT in Reps 1 and 2, AS in Rep 2, and T in Reps 1 and 2. Because results can be obtained in < 12 h, the capacitance procedure with further refinement may provide an excellent alternative to conducting PPC as a means of predicting potential spoilage of fish such that the fillets of inferior quality (i.e., those that will spoil rapidly) may be sent to distribution outlets that are known to move fish products quickly and are able to sell the fish before it spoils.
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Han, Dongmei, Zhen Guo, Shou Chen, Min Xiao, Xiaohua Peng, Shuanjin Wang, and Yuezhong Meng. "Enhanced Properties of Biodegradable Poly(Propylene Carbonate)/Polyvinyl Formal Blends by Melting Compounding." Polymers 10, no. 7 (July 13, 2018): 771. http://dx.doi.org/10.3390/polym10070771.
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Polyvinyl formal (PVF) was first synthesized via the reaction of poly(vinyl alcohol) (PVA) and formaldehyde. The synthesized PVF exhibits a high decomposition temperature, glass transition temperature, and low melting point compared to pristine PVA. The synthesized PVF can be melt processed at temperatures much lower than PVA. Poly(propylene carbonate) (PPC) and the as-made PVF were melt blended in a Haake mixer. The mechanical properties, thermal behaviors, and morphologies of PPC/PVF blends were investigated. Compared to the pure PPC, PPC/PVF blends show higher tensile strength and Vicat softening temperature. Thermogravimetric (TGA) result reveals that the thermal stabilities of PPC/PVF blends decreased with the increase of the content of PVF. Scanning electron microscopy (SEM) observation indicates that the interfacial compatibility of the PVF and PPC matrix is better than that of the PVA and PPC matrix. The PPC/PVF blends show much better comprehensive properties compared to pure commercial PPC, which provides a practical way to extend the application of PPC copolymer.
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Crespo-Garcia, Maite, Diego Pinal, Jose L. Cantero, Fernando Díaz, Montserrat Zurrón, and Mercedes Atienza. "Working Memory Processes Are Mediated by Local and Long-range Synchronization of Alpha Oscillations." Journal of Cognitive Neuroscience 25, no. 8 (August 2013): 1343–57. http://dx.doi.org/10.1162/jocn_a_00379.
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Different cortical dynamics of alpha oscillations (8–13 Hz) have been associated with increased working memory load, which have been mostly interpreted as a neural correlate of functional inhibition. This study aims at determining whether different manifestations of load-dependent amplitude and phase dynamics in the alpha band can coexist over different cortical regions. To address this question, we increased information load by manipulating the number and spatial configuration of domino spots. Time–frequency analysis of EEG source activity revealed (i) load-independent increases of both alpha power and interregional alpha-phase synchrony within task-irrelevant, posterior cortical regions and (ii) load-dependent decreases of alpha power over areas of the left pFC and bilateral posterior parietal cortex (PPC) preceded in time by load-dependent decreases of alpha-phase synchrony between the left pFC and the left PPC. The former results support the role of alpha oscillations in inhibiting irrelevant sensorimotor processing, whereas the latter likely reflect release of parietal task-relevant areas from top–down inhibition with load increase. This interpretation found further support in a significant latency shift of 15 msec from pFC to the PPC. Together, these results suggest that amplitude and phase alpha dynamics in both local and long-range cortical networks reflect different neural mechanisms of top–down control that might be crucial in mediating the different working memory processes.
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FALCÃO, ANTONIO L. E., SEBASTIÃO ARAÚJO, DESANKA DRAGOSAVAC, RENATO G. G. TERZI, ROSANA A. S. THIESEN, ELIANE A. CINTRA, LUIZ A. C. SARDINHA, ANTÔNIO CAPONE NETO, VENÂNCIO P. DANTAS FILHO, and ELIZABETH M. A. B. QUAGLIATO. "Hemometabolismo cerebral: variações na fase aguda do coma traumático." Arquivos de Neuro-Psiquiatria 58, no. 3B (September 2000): 877–82. http://dx.doi.org/10.1590/s0004-282x2000000500013.
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OBJETIVO: avaliar as interrelações entre as alterações hemometabólicas cerebrais e sistêmicas em pacientes com traumatismo craniencefálico (TCE) grave submetidos a um protocolo terapêutico padronizado. DESENHO: estudo prospectivo, intervencionista em pacientes com coma traumático. LOCAL: uma UTI geral em hospital universitário. PACIENTES E MÉTODOS: vinte e sete pacientes (21M e 6F), idade 14-58 anos, com TCE grave, com três a oito pontos na escala de coma de Glasgow, foram avaliados prospectivamente segundo um protocolo cumulativo padronizado para tratamento da hipertensão intracraniana aguda, o qual incluía medidas rotineiras da pressão intracraniana (PIC) e da extração cerebral de oxigênio (ECO2). Foram analisadas as interrelações hemometabólicas envolvendo: pressão arterial média (PAM), PIC, pressão parcial de gás carbônico arterial (PaCO2), ECO2, pressão de perfusão cerebral (PPC) e extração sistêmica de oxigênio (ESO2). INTERVENÇÕES: apenas as padronizadas no protocolo terapêutico. RESULTADOS: não houve correlação entre a ECO2 e a PPC (r = -0,07; p = 0,41). Houve correlação inversa entre a PaCO2 e a ECO2 (r = -0,24; p = 0,005) e direta entre a ESO2 e a ECO2 (r = 0,24; p = 0,01). A mortalidade geral dos pacientes foi de 25,9% (7/27). CONCLUSÃO: 1) a PPC não se correlaciona com a ECO2 em quaisquer níveis de PIC; 2) a ECO2 está estreitamente relacionada aos diferentes níveis de PaCO2 ; e 3) durante a hiperventilação otimizada existe um acoplamento entre a ECO2 e a ESO2.
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Asiri, Abdullah M., Kalsoom Akhtar, Jongchul Seo, Hadi M. Marwani, Dowan Kim, Haksoo Han, and Sher Bahadar Khan. "Development of Polymer Based Nanocomposites as a Marker of Cadmium in Complex Matrices." Journal of Nanomaterials 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/942756.
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Poly(propylene carbonate)/β-cyclodextrin (PPC-BCD) nanocomposites were developed as effective extractor for a specific extraction and separation of cadmium(II) by use of inductively coupled plasma-optical emission spectrometry. The selectivity of nanocomposites with different wt% of BCD (PPC-BCD 0.5, PPC-BCD 1, PPC-BCD 3, PPC-BCD 5, or PPC-BCD 10) was investigated toward Cd(II). Based on selectivity and pH studies, Cd(II) was the most quantitatively adsorbed on PPC-BCD 5 phase at pH 6, indicating that PPC-BCD 5 was the most selective toward Cd(II) among other nanocomposites. On the basis of adsorption isotherm study, the superior adsorption capacity of PPC-BCD 5 phase for Cd(II) was found to be 149.25 mg·g−1, following the Langmuir adsorption isotherm model. The kinetic of adsorption for Cd(II) has been examined by pseudo-first- and second-order models. The kinetic exploration suggested a pseudo-second-order kinetic model for the adsorption of Cd(II) on the PPC-BCD 5. Additionally, results of thermodynamic investigation demonstrated favorable spontaneous process for the adsorption mechanism of PPC-BCD 5 toward Cd(II).
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Lian, Ziyang, Shan Jiang, Hongping Hu, Longxiang Dai, Xuedong Chen, and Wei Jiang. "An Enhanced Plane Wave Expansion Method to Solve Piezoelectric Phononic Crystal with Resonant Shunting Circuits." Shock and Vibration 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/4015363.
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An enhanced plane wave expansion (PWE) method is proposed to solve piezoelectric phononic crystal (PPC) connected with resonant shunting circuits (PPC-C), which is named as PWE-PPC-C. The resonant shunting circuits can not only bring about the locally resonant (LR) band gap for the PPC-C but also conveniently tune frequency and bandwidth of band gaps through adjusting circuit parameters. However, thus far, more than one-dimensional PPC-C has been studied just by Finite Element method. Compared with other methods, the PWE has great advantages in solving more than one-dimensional PC as well as various lattice types. Nevertheless, the conventional PWE cannot accurately solve coupling between the structure and resonant shunting circuits of the PPC-C since only taking one-way coupling from displacements to electrical parameters into consideration. A two-dimensional PPC-C model of orthorhombic lattice is established to demonstrate the whole solving process of PWE-PPC-C. The PWE-PPC-C method is validated by Transfer Matrix method as well as Finite Element method. The dependence of band gaps on circuit parameters has been investigated in detail by PWE-PPC-C. Its advantage in solving various lattice types is further illustrated by calculating the PPC-C of triangular and hexagonal lattices, respectively.
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Jung, Tae Woo, Sung Tae Kim, Jun Ho Lee, Soo In Chae, Kwang Woo Hwang, Yoon Hee Chung, Hyoung-Chun Kim, et al. "Phosphatidylcholine Causes Lipolysis and Apoptosis in Adipocytes through the Tumor Necrosis Factor Alpha-Dependent Pathway." Pharmacology 101, no. 3-4 (November 29, 2017): 111–19. http://dx.doi.org/10.1159/000481571.
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A phosphatidylcholine (PPC) formulation has been used to treat cellulite; however, its underlying mechanism of action remains unclear. In this study, we demonstrated that PPC induces lipolysis and apoptosis in adipocytes, and evaluated a possible tumor necrosis factor alpha (TNFα)-dependent pathway, whereby PPC exerts these effects. For in vitro study, fully differentiated 3T3-L1 cells, mouse adipocytes were treated with various concentrations of PPC and cell apoptosis and lipolysis were assayed. For in vivo experiments, mice fed on a high-fat diet for 8 weeks were injected twice to abdominal subcutaneous fat tissues of either vehicle or PPC. We found that PPC induced lipolysis and apoptosis dose-dependently in fully differentiated 3T3-L1 cells. In addition, PPC augmented both expression and release of TNFα in a dose-dependent fashion. Induction of TNFα by PPC was associated with the stimulation of nuclear factor kappa B (NFκB)-mediated transcriptional activity. Small interfering RNA (siRNA)-mediated suppression of NFκB abrogated the effect of PPC on TNFα secretion. Suppression of TNFα with specific siRNA abrogated the effects of PPC on lipolysis and apoptosis. Through in vivo experiments, we demonstrated that PPC injection not only stimulated the local lipolysis and apoptosis, resulting in weight loss, but also induced TNFα mRNA expression and neutrophil infiltration. Furthermore, PPC injection prevented lipogenesis and suppressed the mRNA expression of adipokines (such as adiponectin and leptin), due to the down-sizing of adipocytes. In conclusion, we suggest that PPC induces lipolysis and apoptosis in adipocytes through TNFα-dependent pathways.
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Matsuda, Masayuki, Yoshiro Kai, Suzuka Harada, Kentaro Suzuki, Shigeto Hontsu, and Shigeo Muro. "Duodenal Metastasis of Pulmonary Pleomorphic Carcinoma: A Case Report." Case Reports in Oncology 14, no. 3 (October 21, 2021): 1511–15. http://dx.doi.org/10.1159/000519664.
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Pulmonary pleomorphic carcinoma (PPC) is a rare subtype of lung sarcomatoid carcinoma that has a poor prognosis, and no standard therapy has been established. Here, we report the case of a 74-year-old man with PCC who showed rare duodenal metastasis. He was referred to our hospital with a mass shadow in the right lung. The patient was diagnosed with PPC clinical stage II B on the basis of immunohistochemical staining from bronchoscopy, and the tumor proportion score of programmed death-ligand 1 was 80%. He did not want any treatment. A year and a half later, progressive anemia was detected. The primary tumor was stable; however, abdominal computed tomography and esophagogastroduodenoscopy revealed a duodenal tumor with stenosis. He was diagnosed with duodenal metastasis from PPC, and he underwent gastrojejunal bypass surgery to prevent bowel obstruction. After surgery, he received pembrolizumab for chemotherapy. However, owing to the progression of peritoneum dissemination, he died 2 months later due to the onset of melena.
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Souza, Almir Pereira de, Márlis Langenegger de Rezende, Newton Nunes, Celina Tie Nishimori, Paulo Sérgio Patto dos Santos, and Danielli Parrilha de Paula. "Alterações cardiovasculares e intracranianas promovidas pela buprenorfina em cães anestesiados com desflurano." Ciência Rural 34, no. 3 (June 2004): 815–20. http://dx.doi.org/10.1590/s0103-84782004000300025.
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Objetivou-se com a realização deste experimento, estudar possíveis alterações nas variáveis cardiovasculares e intracranianas promovidas pela buprenorfina, em cães anestesiados com desflurano. Para tanto, foram utilizados oito cães adultos, clinicamente saudáveis. A anestesia foi induzida com propofol (8 mg/kg IV) e em seguida os animais foram intubados com sonda orotraqueal de Magill, a qual foi conectada ao aparelho de anestesia volátil para administração de desflurano (1,5 CAM). Os animais foram mantidos sob ventilação controlada durante todo o período experimental. Após 20 minutos do posicionamento do cateter de pressão intracraniana (PIC), administrou-se buprenorfina (0,02 mg/kg IV). Foram avaliados: PIC; pressão de perfusão cerebral (PPC); FC; PAS, PAM e PAD; débito cardíaco (DC); pressão venosa central (PVC); e pressão da artéria pulmonar (PAP). As colheitas foram feitas nos seguintes momentos: M1 - 20 minutos após o posicionamento do cateter de PIC; M2 - 15 minutos após a administração do opióide; M3, M4 e M5 - de 15 em 15 minutos após M2. A avaliação estatística dos dados foi efetuada por meio de ANOVA seguida do Teste de Tukey (p<0,05). A PIC permaneceu estável durante todo o período experimental. Entretanto, registrou-se uma queda acentuada, estatisticamente significativa, da PPC após o M2. As variáveis cardiovasculares FC, PAS, PAM, PAD, DC e PAP, apresentaram redução significativa de seus valores após M2, mantendo-se estáveis no restante do período experimental. Quanto à PVC, o teste estatístico não registrou alterações significativas. Assim, pôde-se concluir que a buprenorfina não interferiu na PIC. Entretanto, a queda dos índices cardiovasculares, especialmente da PAM, determinada pela administração do opióide, causa redução da PPC em cães anestesiados com desflurano.
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Watson, Christopher, Nazia Nawaz, Wiah Wardiningsih, and Olga Troynikov. "Materials used in industrial workwear for hot workplace environments: Thermal and moisture management attributes." Journal of Industrial Textiles 52 (August 2022): 152808372211417. http://dx.doi.org/10.1177/15280837221141716.
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Materials used in personal protective clothing (PPC) are important from both protection and thermal management perspectives, particularly as PPC frequently covers more than 90% of the wearer’s body. There is extensive literature on the risk factors that contribute to thermal load and the related functional characteristics of the PPC, especially in high-risk categories such as fire fighting and the military. In contrast, research on PPC materials in low-risk categories such as mining and construction and their thermal management attributes is scarce. Nevertheless, workers who wear this type of PPC represent a significant proportion of the industrial workforce, and are commonly required to work in hot and/or humid thermal environments. This study provides new knowledge of the thermal management attributes of materials used in low-level risk PPC by evaluating a selection of 19 workwear materials that are used in low-risk PPC worldwide. In addition, four civilian/corporate wear summer materials were tested to compare against the PPC materials. This study identifies relationships between the structure, physical parameters and functional attributes of materials, providing direction for development of new and improved PPC materials. The results show that there are opportunities to substantially reduce PPC material mass and thickness, whilst still maintaining protective compliance requirements. Further, thermal and moisture management attributes of PPC materials can also be significantly improved to reduce thermal burden.
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Gomes, Claudia, and Altemir José Gonçalves Barbosa. "Inclusão escolar do portador de paralisia cerebral: atitudes de professores do ensino fundamental." Revista Brasileira de Educação Especial 12, no. 1 (April 2006): 85–100. http://dx.doi.org/10.1590/s1413-65382006000100007.
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as atitudes em relação às pessoas com as necessidades especiais representam um dos mais importantes fatores para o sucesso da escola inclusiva. Para avaliar as atitudes do professor quanto à inclusão de portadores de paralisia cerebral (PPC), um questionário com uma escala de atitude foi aplicado em 68 professores de ensino fundamental. Foi evidenciada discordância com relação à inclusão de PPC na escola. A análise fatorial levou a seis fatores que podem explicar tais atitudes: como ensinar PPC em classes normais; sentimentos e emoções de professores na presença de PPC; contato com os PPC; o tipo de educação mais adequado para os PPC; rendimento escolar da sala de aula com a presença de um PPC; e preconceito na sala de aula. Dissonância entre as dimensões afetiva, cognitiva e denotativa das atitudes dos professores foi constatada, a discordância e a dissonância evidenciadas podem representar barreiras quanto à inclusão escolar de PPC.
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Sun, Jing, Liangqiang Wei, Shanshan Luo, Anrong Huang, and Min Shi. "Enhanced properties of the poly(propylene carbonate)/poly(butylene succinate) composites with chain extender." Journal of Thermoplastic Composite Materials 32, no. 8 (July 9, 2018): 1068–77. http://dx.doi.org/10.1177/0892705718785704.
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Poly(propylene carbonate) (PPC) blended with poly(butylene succinate) (PBS) with chain extender (CE) was prepared by melt mixing. Mechanical properties of PPC/PBS composites showed that the addition of CE can increase its tensile strength and unnotched impact strength, and the PPC/PBS composites had higher tensile strength when CE (0.4 wt%) was added into PPC/PBS composites. Thermogravimetric measurements revealed that adding CE to PPC/PBS (70/30 wt%) can improve the thermal decomposition temperatures ( T −5% and T −10%). Dynamic mechanical analysis revealed that the incorporation of CE increased the storage modulus of the PPC/PBS (70/30 wt%) composites.
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Wiendahl, H. H., G. Von Cieminski, and H. P. Wiendahl. "Stumbling blocks of PPC: Towards the holistic configuration of PPC systems." Production Planning & Control 16, no. 7 (October 2005): 634–51. http://dx.doi.org/10.1080/09537280500249280.
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Hyafil, Alexandre. "Disharmony in neural oscillations." Journal of Neurophysiology 118, no. 1 (July 1, 2017): 1–3. http://dx.doi.org/10.1152/jn.00026.2017.
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Cross-frequency phase coupling (PPC) may play an important role in neural processing and cognition. However, a new study unveils a statistical bias in how PPC is detected in neural recordings, questions prior evidence for PPC in hippocampus, and shows PPC tests are dramatically flawed by their confounds with oscillation harmonics.
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Herrmann, Jan-Phillip, Sven Tackenberg, Elio Padoano, and Thilo Gamber. "Approaches of production planning and control under industry 4.0: A literature review." Journal of Industrial Engineering and Management 15, no. 1 (February 1, 2022): 4. http://dx.doi.org/10.3926/jiem.3582.
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Purpose: Industry 4.0 technologies influence how production is planned, scheduled, and controlled. In literature, different classifications of the tasks and functions of production planning and control (PPC) exist, of which one is the German Aachen PPC model. This research aims to identify and classify current Industry 4.0 approaches for planning and controlling production processes and to reveal researched and unexplored areas of the model.Design/methodology/approach: In an exploratory literature review, we review and classify 48 publications on a full-text basis with the Aachen PPC model's tasks and functions. Two cluster analyses reveal researched and unexplored tasks and functions of the Aachen PPC model. Additionally, we give a summary of each reviewed publication.Findings: We propose a cyber-physical PPC architecture, which incorporates current Industry 4.0 technologies, current optimization methods, optimization objectives, and disturbances relevant for realizing a PPC system in a smart factory. Current approaches focus on the in-house PPC, particularly on the control using real-time information from the shop floor. We propose future research directions for the unexplored tasks and functions of the Aachen PPC model.Research limitations/implications: The selection of search terms and the texts' interpretation is based on an individual assessment. The revelation of unexplored tasks and functions of the Aachen PPC model might have a different outcome if the search term combination is parameterized differently.Originality/value: Using the Aachen PPC model, which holistically models PPC, the findings give comprehensive insights into the current advances of tools, methods, and challenges relevant to planning and controlling production processes under Industry 4.0.
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Werneke, Mark W., and Dennis L. Hart. "Categorizing Patients With Occupational Low Back Pain by Use of the Quebec Task Force Classification System Versus Pain Pattern Classification Procedures: Discriminant and Predictive Validity." Physical Therapy 84, no. 3 (March 1, 2004): 243–54. http://dx.doi.org/10.1093/ptj/84.3.243.
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Abstract Background and Purpose. Quebec Task Force Classification (QTFC) and pain pattern classification (PPC) procedures, including centralization and noncentralization, are common classification procedures. Classification was done to estimate validity of data obtained with QTFC and PPC procedures for differentiating patient subgroups at intake and for use in predicting rehabilitation outcomes at discharge and work status at 1 year after discharge from rehabilitation. Subjects. Patients (n=171, 54% male; mean age=37 years, SD=10, range=18–62) with acute work-related low back pain referred for physical therapy were analyzed. Methods. Patients completed pain and psychosocial questionnaires at initial examination and discharge and pain diagrams throughout intervention. Physical therapists classified patients using QTFC and PPC data at intake. Patients were classified again at discharge by PPC (time-dependent PPC). Results. Analysis of variance of showed QTFC and PPC data could be used to differentiate patients by pain intensity or disability at intake. Analysis of covariance showed that intake PPC predicted pain intensity and disability at discharge, but QTFC did not. Logistic regression showed that PPC predicted work status at 1 year, but QTFC did not. Classifying patients over time using time-dependent PPC data reduced the false positive rate by 31% and increased percentage of change in pretest-posttest probability of return to work by 16% compared with classifying patients at intake. Discussion and Conclusion. Results support the discriminant validity of the QTFC data at intake and predictive validity of the PPC data at intake. Tracking PPC over time increases predictive validity for 1-year work status.
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Fan, LQ, RC Cattley, and JC Corton. "Tissue-specific induction of 17 beta-hydroxysteroid dehydrogenase type IV by peroxisome proliferator chemicals is dependent on the peroxisome proliferator-activated receptor alpha." Journal of Endocrinology 158, no. 2 (August 1, 1998): 237–46. http://dx.doi.org/10.1677/joe.0.1580237.
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The 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) family of proteins regulates the levels of the active 17 beta-hydroxy forms of sex steroids. The expression of 17 beta-HSD type IV is induced by peroxisome proliferator chemicals (PPC) in rat liver. In order to characterize more generally the impact of PPC on 17 beta-HSD expression, we determined (1) if expression of other members of the 17 beta-HSD family was coordinately induced by PPC exposure, (2) the tissues in which 17 beta-HSD was induced by PPC, and (3) whether the induction of 17 beta-HSD by PPC was dependent on the peroxisome proliferator-activated receptor alpha (PPAR alpha), the central mediator of PPC effects in the mouse liver. The mRNA levels of 17 beta-HSD I, II, and III were not altered in the liver, kidney, and testis or uterus of rats treated with PPC. The mRNA or 80 kDa a full-length protein levels of 17 beta-HSD IV were strongly induced in liver and kidney, but not induced in adrenals, brown fat, heart, testis, and uterus of rats treated with diverse PPC. In liver and kidneys from treated rats, additional proteins of 66 kDa, 56 kDa, and 32 kDa were also induced which reacted with the anti-17 beta-HSD IV antibodies and were most likely proteolytic fragments of 17 bega-HSD IV. Treatment of mice which lack a functional form of PPAR alpha with PPC, demonstrated that PPC-inducibility of 17 beta-HSD IV mRNA or the 80 kDa protein was dependent on PPAR alpha expression in liver and kidney. Our results demonstrate that 17 beta-HSD IV is induced by PPC through a PPAR alpha-dependent mechanism and support the hypothesis that exposure to PPC leads to alterations in sex steroid metabolism.
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Sylvia Noviani Saing, Gama Satria, Bermansyah, and Irfannuddin. "Effectiveness of Preoperative Incentive Spirometry in Patients Following Elective Thoracotomy for Prevention of Postoperative Pulmonary Complication." Sriwijaya Journal of Surgery 4, no. 2 (June 17, 2021): 332–43. http://dx.doi.org/10.37275/sjs.v4i2.66.
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Background: Thoracotomy can cause postoperative impairment of respiratory function and highly risk turns as Postoperative Pulmonary Complication (PPC). One of strategies to decrease risk of PPC in preoperative evaluation is lung expansion maneuvers include Incentive Spirometry (IS). Incentive Spirometry was breathing technique that sustained maximal inspiration, using device which give visual feedback. This study aims to know effectiveness of using preoperative IS in reducing incidence of PPC in thoracotomy patients.
Methods: Experimental study with post test only design. Comparing emerged PPC with Melbourne Group Scale Version 2 (MDG-2) criteria in elective posterolateral thoracotomy patients who given IS and non IS preoperative. Data were analyzed using chi square test.
Results: Total samples was 32 patients. There was 11 patients had PPC, which 6 recieved IS preoperatively. There was no relation between PPC with age, sex, height, smoking history proportion (p value>0,05). Chi square test showed there was no relation between using IS preoperative and PPC incidence(p>0,710).
Conclusions: IS preoperative was not effective in preventing PPC in elective thoracotomy patients.
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Maggio, C. Di, C. Massullo, C. Imperatori, O. Palazzolo, B. Farina, M. Brinciotti, M. Ferrara, V. Guidetti, and A. Terrinoni. "Triple network in adolescents with borderline personality disorder, early traumatic experiences and dissociative symptoms: An eloreta study." European Psychiatry 64, S1 (April 2021): S140. http://dx.doi.org/10.1192/j.eurpsy.2021.384.
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IntroductionTriple Network Model (TNM), which considers the dynamic interaction between Default Mode (DMN), Salience (SN), and Central Executive (CEN) networks, explains clinical features in mental disorders from a neurophysiological perspective. Some studies highlight the increased connectivity in TNM in adults with Borderline Personality Disorder (BPD), but little is known about adolescents.ObjectivesThe aim of our preliminary study was to investigate TN functional connectivity (FC) in BPD adolescents with a history of traumatic experiences, and its correlation with dissociative symptoms.Methods15 BPD adolescents (DSM-5 criteria) with early traumatic experiences were compared to 15 healthy controls, matched for sex and age. Dissociation Questionnaire (DIS-Q) was administered. Eyes-closed resting-state (RS) EEG recordings were performed (19 electrodes; 10- 20 system) and analyzed using Exact Low-Resolution Electromagnetic Tomography software (eLORETA). FC was computed for all frequency bands and 9 Regions of Interest for TNM.ResultsBPD adolescents showed a hyper-connection between CEN and DMN [dorso-lateral prefrontal cortex (dlPFC) and posterior cingulate cortex (PCC); PCC and left posterior parietal cortex (PPC)] and within the CEN (left and right PPC). The strength of PCC-dlPFC and left-right PPC connections was correlated with dissociative symptoms severity.ConclusionsFC alterations can already be identified in BPD adolescents, supporting the need for early diagnosis. Normally DMN and CEN show opposite functioning. In our BPD adolescents, the absence of this “anti-correlation” reflects the typical confusion between internal and external mental states, which clarify their difficulties in metacognition or mentalization. Moreover, in dissociative symptoms, two CEN nodes are also involved, not only DMN as previously described.DisclosureNo significant relationships.
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Sériès, F. "Certains appareils de PPC automatiques (auto-PPC) paraissent aussi efficaces que les PPC classiques dans le traitement du SAOS." Revue des Maladies Respiratoires 21 (June 2004): 159–60. http://dx.doi.org/10.1016/s0761-8425(04)72050-1.
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Benini, Franca, Irene Avagnina, Luca Giacomelli, Simonetta Papa, Anna Mercante, and Giorgio Perilongo. "Pediatric Palliative Care in Oncology: Basic Principles." Cancers 14, no. 8 (April 13, 2022): 1972. http://dx.doi.org/10.3390/cancers14081972.
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About 4 million children with an oncological disease worldwide require pediatric palliative care (PPC) due to the nature of their condition. PPC is not limited to end-of-life care; it is a general approach continuing over the entire disease trajectory, regardless of whether the patient receives any oncological treatment. This review addresses the value of integrating PPC in treating children with cancer, focusing on the basic principles of PPC and its application in pediatric oncology. Moreover, models for PPC implementation in oncology, end-of-life care, and advanced care planning are discussed.
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Haneef, Intan Najwa Humaira Mohamed, Yose Fachmi Buys, Norhashimah Mohd Shaffiar, Sharifah Imihezri Syed Shaharuddin, Abdul Malek Abdul Hamid, Mohd Faizul Mohd Sabri, and Amalina Muhammad Afifi. "Effect of HNT on mechanical and thermal properties of poly(lactic acid)/polypropylene carbonate blends." Polimery 66, no. 9 (October 26, 2021): 459–65. http://dx.doi.org/10.14314/polimery.2021.9.2.
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In this work, the influence of halloysite nanotubes (HNTs) on the mechanical and thermal properties of the poly(lactic acid)/polypropylene carbonate (PLA/PPC 70/30) blend was studied. The HNT was incorporated into the PLA/PPC blend by melt mixing. It was found that addition of 2-6 wt % HNT successfully improved the tensile and flexural strength as well as the flexural and Young’s moduli of PLA/PPC blend, due to the reinforcing effect. Although the elongation at break decreases with increasing HNT content, its value is much higher than that of pure PLA. Moreover, the addition of HNT didnot affect the miscibility of PLA and PPC, since two glass transition temperatures were observed in the DSC thermograms. However, a higher content of HNT may improve the compatibility between PLA and PPC as evidenced by the lower difference between the glass transition temperature of PPC and PLA and reduced crystallinity resulting in higher tensile strength of nanocomposites.Keywords: PLA, PPC, HNT, mechanical properties, thermal properties.
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Dela Cruz, John Wayne. "Plurilingual or not plurilingual? Plurilingual competence and identity of Canadian EAL peers in a francophone post-secondary context." OLBI Journal 12 (December 22, 2022): 139–60. http://dx.doi.org/10.18192/olbij.v12i1.6075.
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Despite emergent research on Canadian additional language (AL) learners’ plurilingualism in post-secondary and officially monolingual school contexts, challenges persist in implementing plurilingual instruction: learners’ plurilingual identities (PI) and plurilingual and pluricultural competence (PPC) are often ignored in favour of the monolingual native speaker model. To help validate learners’ PPC and PI in AL classrooms, this article discusses parts of the results of a mixed-methods study pertaining to the self-perceived PPC and self-reported linguistic identities of adult English as AL student tutors and tutees (N = 20) in a francophone Montréal college. Data from a PI questionnaire, a PPC scale, and interviews reveal that: tutors tend to have higher PPC and identify as bi- or plurilingual; tutees tend to have lower PPC and identify as mono- or bilingual; a lower PPC level is directly related to identifying as monolingual; factors including AL competence level influence participants’ PI. Implications for AL education are discussed.
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Zhou, Linyao, Guiyan Zhao, Jinghua Yin, and Wei Jiang. "Toughening poly(3-hydroxybutyrate) with propylene carbonate plasticized poly(propylene carbonate)." e-Polymers 14, no. 4 (July 1, 2014): 283–88. http://dx.doi.org/10.1515/epoly-2013-0069.
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AbstractPoly(3-hydroxybutyrate) (PHB)/poly(propylene carbonate) (PPC) blends containing various amounts of plasticizer propylene carbonate (PC) were prepared, and the toughness of the blends as a function of temperature was studied. It was found that the brittle-ductile transition temperature (TBD) of PHB toughened by PPC decreased from 60°C to 10°C with the increase in PC content. As PC is the plasticizer of PPC, the mechanical properties, such as Young’s modulus of plasticized PPC with different PC contents, were also studied. Sequentially, the relationship between TBD and the ratio of the Young’s modulus (E1) of the PHB matrix to that of the plasticized PPC elastomer (E2) was investigated. It was found that the Young’s modulus of plasticized PPC should be considerably lower than that of the PHB matrix in order to obtain ’the tough PHB/plasticized PPC blends at a lower temperature. In contrast, the morphology of the dispersed particles also had an important influence on the toughness. When the plasticizer content was more than 20 wt.%, the PPC particles became more spherical and smaller. The toughness could be considerably improved accordingly.
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De Clercq, Eva, Michael Rost, Nadia Pacurari, Bernice S. Elger, and Tenzin Wangmo. "Aligning guidelines and medical practice: Literature review on pediatric palliative care guidelines." Palliative and Supportive Care 15, no. 4 (January 9, 2017): 474–89. http://dx.doi.org/10.1017/s1478951516000882.
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ABSTRACTObjective:Palliative care for children is becoming an important subspecialty of healthcare. Although concurrent administration of curative and palliative care is recommended, timely referral to pediatric palliative care (PPC) services remains problematic. This literature review aims to identify barriers and recommendations for proper implementation of palliative care for children through the looking glass of PPC guidelines.Method:To identify studies on PPC guidelines, five databases were searched systematically between 1960 and 2015: Scopus, PubMed, PsycINFO, the Web of Science, and CINAHL. No restrictions were placed on the type of methodology employed in the studies.Results:Concerning barriers, most of the papers focused on gaps within medical practice and the lack of evidence-based research. Common recommendations therefore included: training and education of healthcare staff, formation of a multidisciplinary PPC team, research on the benefits of PPC, and raising awareness about PPC. A small number of publications reported on the absence of clear guidance in PPC documents regarding bereavement care, as well as on the difficulties and challenges involved in multidisciplinary care teams.Significance of results:Our results indicate that a critical assessment of both the research guidelines and medical practice is required in order to promote timely implementation of PPC for pediatric patients.
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Deshariyanto, Dwi, Anita Intan Nura Diana, and Subaidillah Fansuri. "PERBANDINGAN SYARAT MUTU FISIKA SEMEN PPC DENGAN SEMEN MORTAR (LEM BATA RINGAN)." Jurnal Ilmiah MITSU (Media Informasi Teknik Sipil Universitas Wiraraja) 10, no. 2 (October 24, 2022): 137–44. http://dx.doi.org/10.24929/ft.v10i2.2066.
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Bata ringan dalam pelaksanaannya dilakukan pemasangan dengan menggunakan perekat bata ringan, namun di berbagai tempat khususnya di kabupaten Sumenep pemasangan bata ringan menggunakan semen biasa atau yang banyak beredar dipasaran seperti semen PPC. Berdasarkan perbedaan tersebut penelitian ini akan membandingkan syarat mutu fisika antara semen PPC dengan semen mortar (lem bata ringan) yang ada di kabupaten Sumenep. Tujuan penelitian membandingkan syarat mutu fisika semen PPC dengan semen mortar (lem bata ringan) yaitu untuk mengetahui waktu pengikatan, penurunan atau pengerasan dan kuat tekan antara semen PPC dan semen mortar (lem bata ringan).
Penelitian ini merupakan penelitian eksperimental. Benda uji untuk waktu pengikatan dan pengerasan semen baik semen PPC dan semen mortar (lem bata ringan) dengan membuat bola pasta, sedangkan benda uji untuk kuat tekan dengan membuat benda uji berbentuk kubus 5 x 5 x 5 cm.
Semen PPC menunjukkan terjadi penurunan pada menit 105 sebesar 4.1 mm dan waktu pengikatan awal terjadi pada menit 139 dengan penetrasi 25 mm. Semen PPC memenuhi syarat fisika SNI. Semen mortar (lem bata ringan) selama 150 menit tidak terjadi penurunan dan pengerasan sama sekali, sehingga waktu pengikatan awal semen mortar (lem bata ringan) memenuhi syarat SNI. Kuat tekan semen PPC mempunyai kuat tekan rata – rata sebesar 26.33 MPa, sedangkan semen mortar (lem bata ringan) sebesar 4 MPa. Kuat tekan semen PPC memenuhi syarat SNI, sedangkan semen mortar (lem bata ringan) tidak memenuhi syarat SNI. Semen mortar (lem bata ringan) lebih tepat digunakan dalam pelaksanaan pemasangan bata ringan dan semen PPC lebih kuat jika dibandingkan dengan semen mortar (lem bata ringan).
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de Souza, Tércia Cesária Reis, Araceli Aguilera Barreyro, Sara Rubio Rubio, Yanier Machado González, Konisgmar Escobar García, José Guadalupe Gómez Soto, and Gerardo Mariscal-Landín. "Growth Performance, Diarrhoea Incidence, and Nutrient Digestibility in Weaned Piglets Fed an Antibiotic-Free Diet with Dehydrated Porcine Plasma or Potato Protein Concentrate." Annals of Animal Science 19, no. 1 (January 1, 2019): 159–72. http://dx.doi.org/10.2478/aoas-2018-0045.
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AbstractTwo experiments were conducted to test if dehydrated porcine plasma (DPP) and potato protein concentrate (PPC) could be used as an alternative to antibiotics in starter diets for piglets. Experiment one was conducted to test if DPP and PPC in an antibiotic-free diet affected pig performance, and faecal consistency. Eighty-four piglets weaned at 22 days and weighing 6.9 kg were used. Piglets were fed for two weeks with one of four diets: a positive control diet with antibiotics (C+); and three other diets without antibiotics added with DPP, PPC, or DPP and PPC (DPP+PPC) to measure the average daily feed intake (ADFI), average daily gain (ADG), feed efficiency (FE), and incidence and severity of diarrhoea (ID and ISD respectively). In experiment two, twenty-four piglets weaned at 17 days and weighing 5.7 kg, were implanted at 21 days of age with a T-cannula at the terminal ileum to measure the apparent ileal digestibility (AID) and the apparent total tract digestibility (ATTD) of nutrients. Piglets were fed one of four diets: a positive control diet with antibiotics (C+); a negative control diet without antibiotics (C–), and two diets without antibiotics added with DPP, or PPC. The results of experiment one showed that the DPP diet was the most consumed diet during the first week, and the ADG and FE were similar among treatments. During the second week and the total experimental period the ADFI, ADG, and FE were similar among diets. The ID was lower in the C+ diet than other diets. The ISD was lower in the C+ diet than DPP and DPP+PPC diets; piglets fed PPC diet were similar to piglets fed C+ and DPP and DPP+PPC diets. The results of digestibility showed that crude protein AID was higher in piglets fed C+ and PPC diets than C– and DPP diets. Dry matter ATTD and energy ATTD were higher for piglets fed PPC than other diets. Further, crude protein ATTD of DPP and PPC diets tended to have a similar digestibility to that of C+ diet. The results suggest that PPC is a potential controller of post-weaning diarrhoea.
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Novick, Diego, Narayan Rajan, Rebecca Ming-Huei Cheng, Sae Young Lee, Dong Hyun Koo, Alice Wei, Agota Szende, and Sam Colman. "Assessment for markers of poor prognosis in a real-world evidence study of treatment patterns in patients with HR+/HER2- locally advanced or metastatic breast cancer in Korea and Taiwan." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): e13083-e13083. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e13083.
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e13083 Background: To assess how patient characteristics impact treatment patterns and real-world effectiveness among patients with hormone receptor (HR+)/human epidermal growth receptor 2-negative (HER2-) locally advanced and metastatic breast cancer (ABC) in Korea and Taiwan. Methods: We conducted a retrospective chart review comprising 227 female patients aged ≥ 18 years and diagnosed HR+/HER2- ABC in Korea and Taiwan between 2015-2017. Those having at least one of the following characteristics, shown previously to negatively impact prognosis, formed the poor prognostic cohort (PPC): ECOG PS > 0, not bone-only disease, liver metastases, or negative PgR status. Anonymized data on patient characteristics, treatment pathways, progression-free survival, and grade 3 or higher adverse events (AEs) of interest was abstracted. Descriptive statistics and Kaplan Meier methods were used to assess the outcomes. Results: The mean (range) age was 57.1 (29 - 83) years. A total of 193 (85.0%) patients were PPC. Endocrine regimens were the most frequent first-line therapies used by 50.3% and 67.6% of patients in the PPC and non-PPC cohorts, respectively. Chemotherapy regimens were used by 25.9% and 17.6% as initial systemic therapy and by 60.1% and 35.3% at any time following diagnosis of ABC, for PPC and non-PPC, respectively. The median progression-free survival time, based on first-line therapy, was 8.3 (95%CI: 6.9 – 10.4) months for PPC versus 11.5 (95%CI: 5.5 – 12.0) months in non-PPC. The proportion of patients with at least 1 grade 3 or higher AEs of interest during first-line therapy was higher in the PPC cohort compared to the non-PPC cohort, 54.4% vs. 44.1% respectively. The most common AEs reported were leukopenia, asthenia/fatigue and neutropenia occurring in 27.5%, 28.0% and 20.7% of the PPC cohort and 23.5%, 2.9%, and 14.7% of the non-PPC cohort, respectively. Conclusions: The existence of one or more poor prognostic factors is associated with a higher chemotherapy use any time following diagnosis of ABC, as well as lower median progression-free survival and a higher likelihood of having an adverse event during first line therapy, compared to non-PPC cohort. These results suggest that patient poor prognostic characteristics can be drivers for therapy selection.
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Tendulkar, R. D., K. L. Stephans, C. A. Reddy, K. Martires, A. R. Patel, D. Raj, D. Lowes, T. Geng, E. A. Klein, and J. P. Ciezki. "Correlation of percent of core biopsies positive for prostate cancer and biochemical outcome following I-125 prostate brachytherapy or external beam radiation." Journal of Clinical Oncology 29, no. 7_suppl (March 1, 2011): 40. http://dx.doi.org/10.1200/jco.2011.29.7_suppl.40.
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40 Background: The percentage of positive cores (PPC) on biopsy for prostate cancer has been identified as a predictor of outcome following definitive local treatment. We aim to identify whether this observation holds true for a modern cohort of patients (pts) treated at Cleveland Clinic with permanent prostate brachytherapy (PB) or external beam radiation therapy (EBRT). Methods: We retrospectively reviewed pathology reports of pts treated with either PB or EBRT from our IRB-approved prospective prostate cancer registry. No pts underwent both PB and EBRT. The number of biopsy cores sampled, number of cores positive for prostate cancer, and maximum length of any core positive for prostate cancer were collected. Cox proportional hazards regression was used to analyze biochemical relapse free survival (bRFS) using the nadir + 2 ng/ml definition. Results: We identified 1253 PB and 879 EBRT pts with complete pathology and clinical information. Among PB pts, 46% were low risk, 40% intermediate risk, and 14% high risk, while 78% had <50% PPC, and 22% had >=50% PPC. The 5-year bRFS for PB was 92.0% for <50% PPC, vs. 83.1% for >=50% PPC (HR 2.1, p=0.0005). For PB pts, significant predictors of bRFS on univariate analysis included: PPC, clinical T stage, PSA, biopsy Gleason score, androgen deprivation, and frequency of PSA testing. On multivariate analysis, only PPC, biopsy Gleason score, and PSA frequency remained significant predictors following PB. Among EBRT pts, 11% were low risk, 36% intermediate risk, and 53% high risk, while 55% had <50% PPC, and 45% had >=50% PPC. The 5-year bRFS for EBRT was 85.6% for <50% PPC, vs. 77.1% for >=50% PPC (HR 1.8, p<0.0001). For EBRT pts, significant predictors of bRFS on univariate analysis included: PPC, clinical T stage, PSA, biopsy Gleason score, androgen deprivation, EBRT dose, and frequency of PSA testing. On multivariate analysis, only PPC, biopsy Gleason score, and PSA frequency remained significant predictors following EBRT. Conclusions: Following PB or EBRT, the percent of positive cores for prostate cancer was a significant predictor of bRFS on multivariate analysis, more so than conventional predictors such as T stage and PSA. No significant financial relationships to disclose.
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Qian, Y., F. Y. Feng, S. Halverson, K. Blas, H. M. Sandler, and D. A. Hamstra. "Use of percent positive biopsy cores to predict prostate cancer–specific death in patients treated with dose-escalated radiotherapy." Journal of Clinical Oncology 29, no. 7_suppl (March 1, 2011): 35. http://dx.doi.org/10.1200/jco.2011.29.7_suppl.35.
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35 Background: The percent of positive biopsy cores (PPC)-considered a surrogate of local disease burden-has been shown to predict biochemical failure (BF) after external beam radiation therapy (EBRT), but most series have used conventional dose RT. Dose-escalated RT has been demonstrated to improve prostate cancer outcomes, but the value of PPC is unclear in the setting of RT doses high enough to decrease local failure. Methods: A retrospective evaluation was performed of 651 patients treated to ≥75 Gy with biopsy core information available. Patients were stratified for PPC by quartile, and differences by quartile in BF, freedom from metastasis (FFM), cause specific survival (CSS), and overall survival (OS) were assessed using the log-rank test. Receiver operated characteristic (ROC) curve analysis was utilized to determine an optimal cut-point for PPC. Cox proportional hazards multivariate regression was utilized to assess the impact of PPC on clinical outcome when adjusting for risk group. Results: With median follow-up of 62 months the median number of cores sampled was 7 (IQR: 6–12) with median PPC in 38% (IQR: 17%-67%). On log-rank test, BF, FFM, and CSS were all associated with PPC (p < 0.005 for all), with worse outcomes only for the highest PPC quartile (>67%). There was no observed difference in OS based upon PPC. ROC curve analysis confirmed a cut-point of 67% as most closely associated with CSS (p<0.001, AUC=0.71). On multivariate analysis after adjusting for NCCN risk group and ADT use, PPC>67% increased the risk for BF (p<0.0001, HR:2.1 [1.4–3.0]), FFM (p<0.05, HR:1.7 [1.1 to 2.9]), and CSS (p<0.06 (HR:2.1 [1.0–4.6]). When analyzed as a continuous variable controlling for risk group and ADT use, increasing PPC increased the risk for BF (p < 0.002), metastasis (p < 0.05), and CSS (p < 0.02), with a 1–2% increase in relative risk of recurrence for each 1% increase in the PPC. Conclusions: For patients treated with dose-escalated RT, the PPC adds prognostic value but at a higher cut-point then previously utilized. Patients with PPC >67% remain at increased risk for failure even with dose-escalated EBRT and may receive benefit from further intensification of therapy. No significant financial relationships to disclose.