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Voll, Ane-Idun. "Samhandling mellom skole og PPT : En kvalitativ og kvantitativ studie fra et småskalaprosjekt i regi av Faglig Løft for PPT." Thesis, Norges teknisk-naturvitenskapelige universitet, Pedagogisk institutt, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-17568.
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Faglig Løft for PPT er et 4-årig modellforsøk som avsluttes i 2012. Etablering av prosjektet begrunnes i et behov for kompetanseheving hos PPT. Som en del av det større prosjektet Faglig løft for PPT er det etablert småskalaprosjekt i to kommuner, Samhandlingsprosjektet. Hensikten med å opprette et slikt småskalaprosjekt er å prøve ut ulike samhandlingsstrukturer, bidra til kompetansebygging og prøve ut ulike roller. I den ene kommunen, som er fokus for denne studien, er det opprettet arbeidsgrupper på hver av de seks grunnskolene i kommunen. Bakgrunnen for at kommunen deltar i Samhandlingsprosjektet er et ønske om å se nærmere på og kvalitetssikre den spesialpedagogiske praksisen. Denne kvalitative og kvantitative studien har sett på Samhandlingsprosjektet og arbeidsgruppen ut i fra lærernes opplevelse og erfaring. Hensikten med studien er å undersøke om Samhandlingsprosjektet har hatt effekt for lærerne i arbeidsgruppens opplevelse av samhandling mellom skole og PPT. Funnene fra studien kan med noe forbehold tyde på at Samhandlingsprosjektet har hatt effekt for arbeidsgruppens opplevelse av samhandling mellom skole og PPT. Studien tar utgangspunkt i to forskningsspørsmål, der det første ønsket å undersøke hvilke faktorer lærere som har deltatt i Samhandlingsprosjektet opplever som viktige for samhandling mellom skole og PPT. Funnene fra studien kan tyde på at lærere som har deltatt i Samhandlingsprosjektet opplever avklaring av rolleforventinger, PPTs tilgjengelighet og tilstedeværelse, kvaliteten på hjelpen som tilbys av PPT og handlingskompetanse på egen skole som viktige faktorer for samhandling. Det andre forskningsspørsmålet hadde til hensikt å undersøke om lærere som har vært med i Samhandlingsprosjektet og lærere som ikke har deltatt, har ulik opplevelse av samhandling mellom skole og PPT. Funn fra studien viser at det på enkelte områder kan se ut som det er ulik opplevelse av samhandling mellom skole og PPT, mellom lærere som har deltatt i samhandlingsprosjektet og lærere som ikke har deltatt.
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Spencer, Eleanor Mary. "Transcriptional regulation of preprotachykinin-A (PPT-A) in the hippocampus." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433413.
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Schneider, Georg [Verfasser]. "300 ppt Measurement of the Proton g-Factor / Georg Schneider." Mainz : Universitätsbibliothek Mainz, 2018. http://d-nb.info/1162145307/34.
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Haddley, Kate. "Transcriptional regulation of the preprotachykinin-A (PPT-A) gene in neuronal cells." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408571.
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Mitscherling, Christoph [Verfasser], and Karl-Heinz [Akademischer Betreuer] Gericke. "Selektiver Nachweis der NO-Isotopologe biologischen Ursprungs im unteren ppt-Bereich / Christoph Mitscherling ; Betreuer: Karl-Heinz Gericke." Braunschweig : Technische Universität Braunschweig, 2009. http://d-nb.info/1175829331/34.
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Krause, Arne [Verfasser]. "Supportive Medien in der wissensvermittelnden Hochschulkommunikation : Transdisziplinäre Analysen des Handlungszwecks von Kreidetafel, OHP, PPT und Interactive Whiteboard / Arne Krause." Frankfurt a.M. : Peter Lang GmbH, Internationaler Verlag der Wissenschaften, 2019. http://d-nb.info/1181488923/34.
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Zushin, Peter-James H. "The Selective Effect of Estrogen Receptor Alpha and Beta on Activity and Social Behavior in Neonatal Male Prairie Voles." University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1248102221.
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Habteab, Biniyam Seged. "Implant of a Selective Estrogen Receptor Alpha Agonist to the Male Rat Medial Preoptic Area Maintains Mating Behavior." Digital Archive @ GSU, 2007. http://digitalarchive.gsu.edu/biology_theses/9.
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ABSTRACT Evidence from knockout studies in male mice and from experiments in male rats,in which expression of the estrogen receptor alpha (ERα) gene was inhibited in the medial preoptic area (MPO), suggests that ERα is important in the control of male rat mating behavior. Therefore, in this experiment, we tested the hypothesis that activation of ERα in the MPO is sufficient to maintain mating behavior in castrated male rats receiving subcutaneously (s.c.) dihydrotestosterone (DHT), a non-aromatizable androgen. Accordingly, castrated rats treated with DHT s.c. received MPO implants of either: (i) propyl-pyrazole-triol (PPT) (Stauffer, et al 2000; Katzenellenbogen, et al 2000), a selective ERα agonist, (ii) E2 (positive controls) or (iii) cholesterol (negative controls)and sexual behavior was monitored. PPT was as effective as E2 at maintaining mating behavior suggesting that, in the MPO, ERα is sufficient to mediate responses to E2 that underlie male rat mating behavior.
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Kabir, Abuzar. "Polytetrahydrofuran- and dendrimer- based novel sol-gel coatings for capillary microextraction (cme) providing parts per trillion (ppt) and parts per quadrillion (ppq) level detection limits in conjunction with gas chromatography and flame ionization detection (fid)." [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001192.
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Persson, Anna, and Jessica Tedenhag. "Missbruk av skatteavtal : Kan de föreslagna reglerna i BEPS åtgärdspunkt 6 motverka förfaranden som missbrukar skatteavtal. Om inte, kan Sverige motverka sådana förfaranden genom att tillämpa generalklausulen mot skatteflykt?" Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Redovisning och Rättsvetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-26901.
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BEPS-projektet startades år 2012 för att förhindra att skattesubjekt använder kryphål i skatteavtalen och staternas nationella lagstiftningar för att erhålla skatteförmåner. År 2013 utgav OECD en handlingsplan som identifierar 15 åtgärder som ämnas vidtas. Åtgärdspunkt 6 reglerar problematiken kring hur skatteavtal missbrukas genom att skattesubjekt ”shoppar” efter jurisdiktionen med det skatteavtal som leder till den förmånligaste beskattningen. Åtgärdspunkt 6 föreslår att en specifik LOB-regel eller en generalklausul, PPT-regeln, införs i OECDs modellavtal för att motverka det aktuella förfarandet. LOB-regeln reglerar i vilka specifika situationer en skatteförmån är tillämplig och kan beviljas medan PPT-regeln är av allmän karaktär och innehåller allmänt hållna formuleringar för att täcka in förhållanden som är svåra att förutse på förhand. Uppsatsens syfte är att utreda huruvida de föreslagna reglerna kan uppfylla ändamålet med åtgärdspunkten, att motverka missbruk av skatteavtal. Om detta inte är möjligt undersöks om Sverige kan motverka sådana förfaranden genom att tillämpa generalklausulen mot skatteflykt som återfinns i skatteflyktslagen. Författarna bedömmer att LOB-regeln är allt för komplex i sin nuvarande lydelse vilket försvårar en tillämpning av regeln. Eftersom PPT-regeln är vag ger den utrymme för godtyckliga bedömningar, vilket inte ger ett förutsebart utfall när det inte finns klar vägledning. Författarna är med hänsyn till detta av uppfattningen att reglerna i dess nuvarande lydelse och form inte kan leva upp till syftet med åtgärdspunkt 6. Enligt Peru-målet är skatteflyktslagen rent principiellt tillämplig på förfaranden som omfattas av skatteavtal. Generalklausulen ska då prövas mot förfarandet. Det fjärde rekvisitet, i strid med lagstiftnings syfte, är dock svårtillämpat och domstolens bedömningar varierar. Författarnas anser dock att genom att införa i skatteavtalen att dess syfte inte är att tillåta missbruk av avtalet kan generalklauslen motverka det aktuella förfarandet och skydda mot erodering av den svenska skattebasen vad gäller missbruk av skatteavtal.In 2012 the BEPS project started with the purpose of preventing tax subjects from using loopholes in the tax treaties and national tax laws in order to receive tax benefits. In 2013, the OECD published an action plan that identifies 15 actions that is meant to be taken regarding this issue. Action 6 regulates treaty abuse through treaty shopping, which means that a tax subject is searching for the tax jurisdiction with the tax treaty that leads to the most beneficial taxation. To prevent this, Action 6 suggests that a specific LOB-rule and a general anti-avoidance rule, PPT-rule, should be included in the OECD model convention. The LOB-rule regulates in which specific situations a treaty benefit can be granted. The PPT-rule is more general and contains general wordings to cover situations that is difficult to foresee. The purpose of this thesis is to examine whether the proposed rules can fulfill the purpose of Action 6, to prevent treaty abuse. If not possible, it will be determined if Sweden can prevent treaty abuse by applying the general anti-avoidance rule against tax evasion stated in the Swedish skatteflyktslagen. The authors of the thesis are of the opinion that the LOB-rule is too complex in its current wording which makes it difficult to apply. Since the PPT-rule is vague, there is a wide scope for arbitrary assessments leads to an unpredictable outcome when the guidance is unclear. Therefore, the authors find that the rules in its current wordings cannot satisfy the purpose of Action 6. According to the Peru-judgement the skatteflyktslagen can be applicable to situations that are covered by a tax treaty. The transaction should be tested against the general antiavoidance. The fourth prerequisite, in contravention of the purpose of the legislation, is difficult of apply and the judgements of the court varies. The authors believe that if the treaty preamble includes a statement which clarifies that the intention of the treaty is not to allow treaty abuse, the Swedish general anti-avoidance rule can prevent treaty abuse and thereby protect the Swedish tax base against BEPS regarding treaty abuse.
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Stenberg, Oddbjørn. "Pedagogisk-psykologiske rådgiveres tilnærminger til problematferd i skolen." Doctoral thesis, Norwegian University of Science and Technology, Faculty of Social Sciences and Technology Management, 2006. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-748.
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Denne studien har fokus på PP-rådgiverens perspektiv på arbeid med problematferd i skolen. Jeg valgte å vinkle min prosjektbeskrivelse og det videre arbeidet mot en studie av Pedagogisk - Psykologisk tjeneste (heretter PP-tjenesten). Nærmere bestemt rettes blikket mot PP-rådgiverens erfaringer med og perspektiv på arbeid med hjelpetrengende elever i skolen, deres foresatte og lærere. Å undersøke slike perspektiv kan ha interesse fordi PP-tjenesten har et særlig godt kjennskap til skolen og det som skjer der gjennom sin rolle som skolens hjelpetjeneste. Analysen bygger på intervju av 12 Pedagogisk-psykologiske rådgivere på 4 PP-kontor i Nord-Norge 1999 -2000 og på direkte observasjon i 30 møter av ulike typer som ble gjennomført på disse kontorene. ”Grounded Theory” er brukt som metodologi og metode. Jeg utviklet 5 substantive koder: 1) ”faglig usikkerhet”, 2) ”skjønn og fagkunnskap”, 3) ”å arbeide eklektisk” 4) ”respons på antatte forventninger” og 5) ”diagnosekommunikasjon”. På basis av de substantive kodene utviklet jeg følgende substantive kode: ”å jobbe eklektisk på basis av skjønn og fagkunnskap gir ulik grad av faglig usikkerhet”. I tillegg har jeg utviklet ulike ”typer” PP-rådgivere, ”eksperten”, ”brannslukkeren” og ”analytikeren”. De teoretiske hypotesene som ble utviklet i dette arbeidet har blitt relatert og drøftet i forhold til annen relevant forskning som for eksempel Bernsteins begrep ”den pedagogiske anordning”, der diskurser og makt er sentralt.
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Setsaas, Signe Gro Siss Skarsholt. "Opplevde utfordringer ved økt bruk av nettbaserte kommunikasjonstjenester : En kvalitativ studie av hvilke utfordringer tre ansatte ved Ppt opplever ved økt bruk av nettbaserte kommunikasjonstjenester." Thesis, Norges teknisk-naturvitenskapelige universitet, Pedagogisk institutt, 2010. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-12248.
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Dette forskningsarbeidet er en kvalitativ fenomenologisk studie som har søkt å belyse hvilke utfordringer ansatte ved Ppt opplever i forbindelse med økt bruk av nettbaserte kommunikasjonstjenester. Tilnærmingen som ble valgt bidrar til å forstå meningen i en erfaring av et bestemt fenomen. Ved å intervjue tre forskningsdeltakere har jeg forsøkt å finne en felles kjerne eller essens i deres opplevelse av utfordringer ved nettbaserte kommunikasjonstjenester. Ut fra forskningsmaterialet har jeg kategorisert mine funn i to hovedkategorier. Den første kategorien Opplevde utfordringer ved dataverktøyet har underkategoriene; Tillit og Dokumentasjon, og omhandler blant annet utfordringer ved gjenkjennbarhet og tilgang til dataverktøyet, samt makt aspektet. Den andre hovedkategorien Opplevde utfordringer ved nettprat, har underkategoriene; Særtrekk og Felles forståelse og viser blant annet til mulighet for økt refleksjon og betydningen av å opptre som person-i-relasjon. Ved å undersøke hvilke utfordringer ansatte ved Ppt opplever har jeg ikke først og fremst ønsket å si noe om hvordan de nettbaserte kommunikasjonstjenestene kunne benyttes. Det som var interessant for meg var å kunne si noe om de utfordringene som mine forskningsdeltakere opplevde ved bruk av disse tjenestene. Mine kategorier kan ikke gi et fullstendig bilde av opplevde utfordringer, men jeg mener de kan gi innblikk i verdifulle aspekter ved opplevelsen.
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Nilsson, Linn Christin. ""Det er kanskje bare det at du får en tankevekker" : En kvalitativ intervjustudie av tre læreres opplevelse av å delta i et samhandlingsprosjekt med PPT." Thesis, Norges teknisk-naturvitenskapelige universitet, Pedagogisk institutt, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-17567.
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I denne studien har jeg undersøkt tre læreres opplevelse av å delta i arbeidsgrupper som er opprettet i forbindelse med «Samhandlingsprosjektet», som igjen er initiert av prosjektet «Faglig løft for PPT». Studiens problemstilling er følgende: Hvordan opplever lærerne å delta i arbeidsgruppene? For å finne svar på dette har jeg benyttet kvalitativ metode der det kvalitative forskningsintervjuet har vært datainnsamlingsstrategi. Jeg har intervjuet tre lærere som har deltatt i arbeidsgrupper ved tre ulike skoler. Teorier og litteratur om samarbeid, samordning, kunnskapsutvikling og refleksjon har vært utgangspunkt for forberedelse til studien, utarbeiding av intervjuguide og tolkning av funnene. Studien viser at lærerne opplever at det i arbeidsgruppene har blitt lagt til rette for å dele erfaringer og kunnskaper med kollegaer og PPT. Dette har bidratt til at nye perspektiver har blitt løftet fram og reflektert over. Kunnskapsdeling og refleksjon har ført til at lærerne har handlet på nye, hensiktmessige måter i praksis. Studien viser videre at lærerne opplever at det har vært nyttig å sette av tid til å løse utfordringer med kollegaer og PPT, men at en felles situasjonsforståelse er viktig for å oppnå et vellykket samarbeid.
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Biet, Elodie. "Effet de certaines séquences de l'ADN sur la recombinaison génétique homologue : mise au point d'un nouvel outil moléculaire pour le ciblage de gène dans les cellules eucaryotes." Paris 6, 2002. http://www.theses.fr/2002PA066038.
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Kosberg, Per Arne. "Vi skulle gjerne hatt dere på skolen hele tiden : En kvalitativ studie av samarbeidet mellom tre skoler og PPT i saker som angår lese- og skrivevansker." Thesis, Norges teknisk-naturvitenskapelige universitet, Pedagogisk institutt, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-22639.
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I denne studien har mitt mål vært å finne ut hvordan tre spesialpedagogiske koordinatorer ved tre skoler i en kommune, vurderer samarbeidet mellom PPT og skolen for å hjelpe elever med lese- og skrivevansker. Jeg har ønsket å finne ut hvordan de vurderer bistanden skolene får fra PPT, om kartleggingene er gode nok, om tiltakene PPT foreslår er nyttige, og om skolene klarer å gjennomføre tiltak PPT foreslår. Jeg har også hatt et ønske om at denne studien, gjennom å belyse skolens syn på disse forholdene, kan bidra til at samarbeidet mellom skolene og PPT i den aktuelle kommunen blir enda bedre. For å få svar på problemstillingen, har jeg benyttet kvalitativ forskningsmetode og dybdeintervjuet tre spesialpedagogiske koordinatorer på tre skoler. De spesialpedagogiske koordinatorene mener at dersom PPT bruker mer tid ute på skolene og blir bedre kjent med lærere og elever, vil PPT ikke bli så avhengige av statiske tester, tiltakene vil bli mer tilpasset den enkelte eleven, og ventelisten vil kortes ned. Det uttrykkes et ønske om å få mer veiledning i bruk av praktiske metoder i undervisningen av elever med lese- og skrivevansker. Koordinatorene mener PPT bruker for mye fagspråk i tilbakemeldingsmåtene, slik at lærere og foreldre ikke klarer å nyttiggjøre seg hjelpen fra PPT godt nok. De mener foreldre får for mye informasjon, mens det blir for lite tid til samtale om tiltak. Elevene får for lite informasjon om de praktiske konsekvensene av å ha lese- og skrivevansker. Koordinatorene sier at PPT sine kartlegginger er blitt mye bedre de siste årene, men det uttrykkes generelt noe tvil til gyldigheten av testene skolene og PPT bruker. Koordinatorene mener PPT sine forslag til tiltak ofte er for generelle. Det uttrykkes ønske om at PPT driver opplæring av lærere i bruk av IKT og informerer mer om aktuelle dataprogrammer til bruk i leseopplæringen. Koordinatorene sier PPT ikke er med i forebyggingsarbeidet av lese- og skrivevansker på skolene, men savner heller ikke PPT her. Samtidig uttrykkes klart at skolene trenger å forbedre forebyggingsarbeidet. To koordinatorer uttrykker at innenfor gruppen av elever med lese- og skrivevansker, får kun elever med enkeltvedtak et tilfredsstillende tilbud innenfor lesing/skriving, mens èn koordinator uttrykker at alle med lese- og skrivevansker i utgangspunktet får et godt tilbud, men at dersom mange elever får enkeltvedtak, mister skolen muligheten til å gi alle elever med vansker innenfor lesing og skriving et godt tilbud.
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VALENÇA, Sandra Regina Fonseca de Araújo. "Influência do parasitismo gastrintestinal sobre sinais clínicos, valores de hematócrito (HT) e pproteína plasmática total (PPT), em caprinos e ovinos criados no semi-árido do estado Pernambuco." Universidade Federal Rural de Pernambuco, 2007. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5859.
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It was objectified with this work to search the parasitism frequncy related by farmers and to identify the possible association between the clinical signals, hematological alterations and parasitic infection of goats and sheeps livestock of two cities on Pernambuco State semiarid region, as a part of this State Program of caprine and ovine healthy. A total of 263 goats and 98 sheeps of different breed, young and adults, male and female were used to clinical evaluation and blood and feces sample gasthering whose therefore were send to laboratorial analysis for hematocrit (Ht) measurement, total plasmatic protein dosage (TPP), nematode faecal egg counts (FECs) and fecal culture. The results were evaluated through descriptive association analysis using the EpiInfo 6.02 Statistic Program. Anemia was the most frequent problem, related for 50% of the interviewed farmers, followed by diarrhea with 47,6% of the reports. At about 27% of the ovine samples showed low values of Ht (17% - 23%) whose more than 77% had no clinical disturbs. In the same way, from 25% of caprine samples with low Ht values (8% - 18%) at about68% showed no clinical signs. Just 14,28% of the sheep samples had low TPP values (5 – 5,8 g/dl) whose 85% had no clinical altertions. On caprine population studied, only 5,32% had low TPP values (3,4 – 5,8 g/dl) and of them 85% were considered clinically healthy. Fecal culture was positive for 46,35% of sheep whose at least 57% were considered clinically healthy by clinical evaluation. The OPG was positive for 60% of the goats samples and 73% of them shoned no clinical disturbs. Hematocrit low values (8 – 18%) were observed in 36,58% of sheep and 22% of goats samples in the same way, low values were observed on TPP dosage (3,4 – 5,8 g/dl) in 19,51%. Of ovine and 5,51% of caprine samples, with no dependence of FECs results.The qualitative evaluation (clinical parameters) were not decisive in the identification of parasitized animals and the quantitative analysis (HT, TPP and OPG) were not conclusive for indicate animal illness. It is possible to conclude that rusticity and resistance are important characteristics on the investigated flock.
Objetivou-se com este trabalho pesquisar a freqüência do parasitismo segundo relato de criadores, e identificar a possível associação entre sinais clínicos, alterações hematológicas e infecção parasitária em caprinos e ovinos, criados em dois municípios do Sertão do Estado de Pernambuco, como parte do Programa de Sanidade Caprina e Ovina deste Estado. Foram utilizados 263 caprinos e 98 ovinos, de diferentes raças, jovens e adultos, de ambos os sexos, para avaliação clínica e colheita das amostras de sangue e fezes, destinadas à análise laboratorial para mensuração do hematócrito, dosagem da proteína plasmática total, contagem de ovos de nematóides por gramas de fezes e coprocultura. Os resultados foram avaliados através de análise descritiva de associação, utilizando-se programa estatístico EpiInfo versão 6.02. A anemia foi o problema de maior frequência, sendo relatada por 50% dos criadores, seguida das diarréias com 47,6% dos relatos. Cerca de 27% dos ovinos apresentaram valores de Ht baixos (17% - 23%), dos quais mais de 77% não apresentaram alteração clinica. Da mesma forma, pouco mais de 25% dos caprinos apresentaram valores de Ht baixos (8% – 18%) estando pelo menos 68% destes sem alteração clinica. Apenas 14,28% dos ovinos apresentaram valores de PPT baixos (5 - 5,8 g/dl), destes, cerca de 85% não manifestaram alteração clínica. Entre os caprinos, apenas 5,32% demonstraram valores de PPT baixos (3,4 – 5,8 g/dl), também com pouco mais de 85% dos animais sadios quanto à avaliação clínica. Dos ovinos avaliados, 46,35% foram positivos ao exame coproparasitológico, destes, pelo menos 57% apresentaram-se sadios quanto à avaliação clínica. Entre os caprinos, 60% foram positivos à contagem de OPG, estando pelo menos 73% destes sem alteração clínica. Valores baixos de Ht (8 – 18%) foram observados em apenas36,58% dos ovinos e em 22% dos caprinos, bem como, valores baixos de PPT (3,4 – 5,8 g/dl) foram observados em 19,51% dos ovinos e em 5,51% dos caprinos, independente do resultado da contagem de OPG. As avaliações qualitativas (exame clínico) não foram decisivas na identificação de indivíduos parasitados e as análises quantitativas (Ht, PPT e Contagem de OPG) não significaram animais enfermos. Os achados demonstraram que a rusticidade e a resistência dos animais do rebanho foram características predominantes nesta pesquisa.
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Dunigan, Anna I. "Actions of Selective Estrogenic Drugs Implanted Into the Medial Amygdala on Male Rat Mating Behavior." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/biology_theses/36.
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Estrogen stimulation of the medial amygdala (MEA) of the brain promotes male rat mating behavior. However, selective stimulation of either of the estrogen receptor subtypes found in the MEA (ERα or ERβ) does not support mating behavior. We tested the hypothesis that dual stimulation of ERα and ERβ is required to activate estrogen-dependant neural circuits in the MEA responsible for mating by local treatment of MEA with a combination of selective estrogenic agonists: propyl pyrazole triol (PPT, an ERα agonist ) and diarylpropionitrile (DPN, an ERβ agonist) administered to castrated, DHT maintained male rats. Estradiol (E2) or cholesterol (Chol) MEA implants served as positive and negative controls respectively. The animals receiving a mixture of PPT and DPN into the MEA displayed higher levels of mating behavior than the Chol treated animals but lower levels of mating behavior than the E2 treated animals.
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Stechmann, David Paul. "Numerical analysis of transient Teflon ablation in pulsed plasma thrusters." Link to electronic thesis, 2007. http://www.wpi.edu/Pubs/ETD/Available/etd-071607-205417/.
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Fjellstad, Marianne Hveding. "«Jeg hadde forventninger om å få råd» : En kvalitativ intervjustudie av tre læreres opplevelse av å delta i et prosjekt med overordnet målsetning om styrket samhandling mellom skole og PPT." Thesis, Norges teknisk-naturvitenskapelige universitet, Pedagogisk institutt, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-17562.
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Fokuset for denne masteroppgaven har vært å undersøke hvordan lærere opplevde samhandlingen i et reflekterende team og om de opplevde samhandlingen som relevant for praksis. Det reflekterende team, som lærerne deltok i var initiert av «Samhandlingsprosjektet» som igjen var i regi av «Faglig Løft for PPT». Teoretisk utgangspunkt for studien har vært samhandling, taus kunnskap og praktisk yrkesteori. Videre ble det brukt ulike teorier og tidligere forskning om samarbeid, samordning, refleksjon og handlings kompetanse. For å svare på problemstillingen ble kvalitativ forskningsmetode brukt. Datamaterialet ble innhentet ved bruk av intervju på tre lærere som deltok i teamet. Analysen vart gjennomført ved å kategorisere de tema som kom fram i intervjuene. Ved å bruke setninger, ord og uttrykk fra forskningsdeltakerne formet det seg tre hovedkategorier; opplevelse av samarbeid lærerne imellom, opplevelse av egen utvikling som lærer og opplevelse av at det er nyttig for praksis. Disse ga rammen for forståelsen om de erfaringene og opplevelsene forskningsdeltakerne har gjort seg. Samarbeidet lærerne imellom ble løftet fram som positivt mens samhandlingen med PPT ble sett på som utfordrende og med muligheter for forbedringer. Lærerne opplevde også å utvikle seg som lærere gjennom refleksjon og bruk av analysemodellen. Samarbeidet og refleksjonen opplever lærerne at har hatt positiv virkning inn i klasserommene, og slik endret deres praksis.
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Zauer, Mario, Frank Meissner, Rudolf Plagge, and André Wagenführ. "Capillary pore-size distribution and equilibrium moisture content of wood determined by means of pressure plate technique." De Gruyter, 2016. https://tud.qucosa.de/id/qucosa%3A38475.
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This paper deals with the determination of the capillary pore-size distribution (CPSD) and equilibrium moisture content (EMC) of untreated and thermally modified (TM) Norway spruce [Picea abies (L.) Karst.] by means of the pressure plate technique (PPT). Desorption experiments were conducted at very high values of relative humidity (RH) in the range between 99.2% and 100%. The thermal modification of spruce results in an alteration of the CPSD, owing to the formation of intercellular cracks in the middle lamella, as a result of cell-wall compression. The desorption curves for both untreated and TM spruce show an extremely upward bend at 99.97% RH. This step reflects an EMC of 38.1% for untreated spruce and 33.8% for TM spruce. None of the samples shrunk during the PPT measurements. Following desorption experiments at 97.4% RH, all samples shrunk. This step reflects an EMC of 27.9% for untreated spruce and 21.7% for TM spruce.
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D'Anniballe, Alessandro. "Development of a sizing tool for preliminary mission analysis and design of propulsion systems for orbit control of small satellites in LEO -VLEO." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14719/.
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The ever-growing necessity for faster and cheaper access to space, makes the building of artificial satellites to shift more and more towards small measures. The most exemplar case of small satellites is given by the so called CubeSats, i.e. modular satellites practically ‘built in blocks’ of approximately the same size and weight. Such an approach allows to fasten the design and decrease the overall project complexity, but at the same time has many limitations. The main one is equipping the satellites with a propulsion system for the control of their operative orbit. Such a task normally requires a consistent amount of propellant, and so a specific dedicated propulsion system, that weighs consistently (in terms of both mass and volume) on the budget of these small spacecrafts.
The present thesis studies the feasibility of providing small satellites with a propulsion system that would enable them to perform orbit control maneuvers all along the mission duration. The concept is to create a computer tool able to carry out a rapid analysis of the satellite mission, for the determination of the needed Δv, and then a preliminary design of the main components of the required propulsion system. Different propulsion technologies can in this way be considered, being then able to do a trade-off to choose the best solution, in terms of mass and performances.
Satellite models ranging from nano to mini-sat standard in LEO-VLEO missions of different durations (2, 5 and 7 years) have been used for feasibility simulations, and re-sults show that the use of some propulsion technology is possible to reach the fixed mission goals.
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Dzojic, Helena. "Adenovirus-mediated CD40 Ligand Immunotherapy of Prostate and Bladder Cancer." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7810.
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Enea, Catalin. "Treaty shopping : En analys av OECDs föreslagna åtgärder i Action 6, särskilt med beaktande av existerande rättsmedel mot treaty shopping." Thesis, Uppsala universitet, Juridiska institutionen, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-277112.
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För att skydda stater mot treaty shopping och annat missbruk av skatteavtal, har OECD utarbetat förslag till en rad åtgärder som begränsar rätten till skatteavtalets förmåner. De viktigaste åtgärderna som föreslås är en LOB-regel, en PPT-regel samt ändringar i skatteavtalets titel och preambel som anger att skatteavtalets syfte är att hindra skatteflykt. Alla länder är överens om att vidta minst någon eller några av dessa åtgärder dvs. ändringarna i skatteavtalets titel och preambel samt antingen 1) PPT-regeln och LOB-regeln eller 2) bara PPT-regeln eller 3) bara LOB-regeln. I skrivande stund arbetar Finansdepartementet för att avgöra vilka av dessa åtgärder Sverige bör implementera. Av analysen i denna uppsats framgår det att både LOB-regeln och PPT-regeln i sina nuvarande former riskerar att brista i kraven på förutsebarhet och rättssäkerhet. Med andra ord blir det svårt för skattebetalaren att förstå villkoren i dessa regler som berättigar till skatteavtalsförmåner. LOB-regeln innehåller till stor del objektiva kriterier som skulle kunna främja förutsebarheten men regelns komplexitet, omfattning och till viss del brist på riktlinjer vad gäller tolkning och tillämpning av vissa rekvisit påverkar förutsebarheten negativt. Det kan konstateras att vissa kriterier i LOB-regeln är för restriktiva och det uppstår en risk för att skattebetalaren vägras rätten till skatteavtalets förmåner även i de situationer när denne varit i god tro och inte haft för avsikt att bedriva treaty shopping eller på annat sätt missbruka skatteavtalet.Till skillnad från LOB-regeln som innehåller en uppräkning av objektiva kriterier, är PPT-regeln en generalklausul mot skatteflykt. PPT-regeln är därför allmänt utformad och har ett brett tillämpningsområde som avser att täcka alla skatteflyktssituationer som inte kunnat förutses av lagstiftaren. I likhet med många andra generalklausuler har PPT-regeln en mer subjektiv karaktär och är vag i vissa delar vilket drabbar rättssäkerheten och förutsebarheten. Slutsatsen är att, för att motverka treaty shopping, skulle det räcka med att tydligt ange i skatteavtalet ett syfte att motverka skatteflykt och skatteundandragande. PPT-regeln är också en lämplig åtgärd mot treaty shopping under förutsättning att vissa rekvisit förtydligas och mer vägledning ges om vilka situationer som regeln avser att träffa. Detta behövs i syfte att förbättra rättssäkerheten och förutsebarheten och motverka eventuellt godtycke och missbruk. I annat fall kan ett osäkert rättsläge skapa en risk för dubbelbeskattning som kan drabba internationell handel och tillväxt. Det kan däremot vara svårt att precisera de omständigheter som ska beaktas vid en prövning enligt PPT-regeln och samtidigt behålla regelns karaktär av generalklausul.
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Sadrmomtaz, Alireza. "Modification of a medical PET scanner for PEPT studies." Thesis, University of Birmingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.668322.
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Azerêdo, Daniel Mendes. "Pesquisas sob amostragem informativa utilizando o FBST." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/45/45132/tde-19082013-161233/.
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Pfeffermann, Krieger e Rinott (1998) apresentaram uma metodologia para modelar processos de amostragem que pode ser utilizada para avaliar se este processo de amostragem é informativo. Neste cenário, as probabilidades de seleção da amostra são aproximadas por uma função polinomial dependendo das variáveis resposta e concomitantes. Nesta abordagem, nossa principal proposta é investigar a aplicação do teste de significância FBST (Full Bayesian Significance Test), apresentado por Pereira e Stern (1999), como uma ferramenta para testar a ignorabilidade amostral, isto é, para avaliar uma relação de significância entre as probabilidades de seleção da amostra e a variável resposta. A performance desta modelagem estatística é testada com alguns experimentos computacionais.Pfeffermann, Krieger and Rinott (1998) introduced a framework for modeling sampling processes that can be used to assess if a sampling process is informative. In this setting, sample selection probabilities are approximated by a polynomial function depending on outcome and auxiliary variables. Within this framework, our main purpose is to investigate the application of the Full Bayesian Significance Test (FBST), introduced by Pereira and Stern (1999), as a tool for testing sampling ignorability, that is, to detect a significant relation between the sample selection probabilities and the outcome variable. The performance of this statistical modelling framework is tested with some simulation experiments.
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Xi-Hua, Li. "A Real-time Counting-measuring Method for PPM(PPK) Signals." International Foundation for Telemetering, 1991. http://hdl.handle.net/10150/612915.
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International Telemetering Conference Proceedings / November 04-07, 1991 / Riviera Hotel and Convention Center, Las Vegas, NevadaOn the disscussion of custom real-time counting-measuring method, this paper presents a new method suitable for the working condition of non-man duty, which possesses the feature of 100ns counting-measuring accuracy and high fidelity. In addition, the concept of “Signal-time/digit converter” is proposed for the first time and the principle and working procedure of this method are introduced in brief.
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Boutimah, Fatima. "Activité antisens de Peptide nucleic acids (PNAs) couplés à des transporteurs peptidiques." Paris 5, 2009. http://www.theses.fr/2009PA05P613.
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Les PNAs ciblant la région codante d’un ARN messager permettent par stratégie antisens de bloquer l’élongation de la traduction. Avant ce travail, seuls les PNAs riches en thymines et capables de former des triplexes avaient été démontrés capables d’une telle activité. Afin d’élargir la variété de séquences ciblées, nous avons montré que des PNAs polypyrimidiques, formant des duplexes ou des triplexes, arrêtent aussi efficacement l’élongation de la traduction. Ces PNAs AS ciblent la séquence polypurine tract du messager de la protéine intégrase du virus VIH-1. Nous avons montré que cette séquence, qui est composée de guanines contiguës, est engagée dans des structures très stables que les PNAs sont capables d’envahir. Ces mêmes PNAs présentent également une activité antisens spécifique dans des cellules humaines perméabilisées. En collaboration avec l’équipe de Gérard Chassaing1, nous avons évalué la capacité de différents peptides pénétrants à véhiculer ces PNAs dans les cellules. Nous avons sélectionné un transporteur peptidique RW9(RRWWRRWRR) qui permet au PNA transporté d’inhiber spécifiquement l’expression du messager cible et l’efficacité est presque identique à celle obtenue dans les cellules perméabilisées. De plus, des concentrations submicromolaires du conjugué PNA-RW9 sont suffisantes pour induire une inhibition et un transport efficace. Aussi, cette internalisation est rapide et aboutit à une forte localisation nucléaire du PNA, qui échappe à un emprisonnement vésiculaire. Ainsi, ce travail ouvre des perspectives importantes pour l’utilisation des conjugués PNA afin de générer des protéines tronquées ayant un rôle de dominants négatifs d’intérêt biologiquePNAs targeting the coding region of a messenger RNA allow, by antisense strtategy, to block translation elongation. Before this work, only thymine-rich PNAs able to form triplex, have been shown with such an activity. To enlarge sequence variety that can be targeted, we have shown that duplex and triplex-forming polypyrimidic PNAs are both able to block efficiently the elongation step. These PNAs target the polypurine tract sequence inside the coding region of the integrase protein mRNA of the HIV-1 virus, that is made of contiguous guanines, and is implicated in very stable secondary structures that PNAs can invade. These same PNAs have also an antisense activity in permeabilized human cells. In collaboration with Gérard chassaing’s group1, we assessed the ability of different Cell Penetrating Peptides (CPPs) to deliver PNAs inside human cells. We thus selected a very efficient peptidic carrier, named RW9 (RRWWRRWRR) that allow the carried PNA to inhibit messenger expression with an antisense activity efficiency that is quite similar to the one obtained in artificially permeabilized cells. Moreover, submicromolar concentrations of PNA-RW9 conjugate are sufficient to observe an efficient delivery and inhibition. This uptake is a rapid phenomenon that entails a strong nuclear PNA localization outside endosomal or lysosomal vesicles. Consequently, this work opens important outlooks for using PNA-CPPs conjugates to induce truncated proteins that can play a dominant-negative role with a therapeutic interest
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Xi-Hua, Li. "A NEW DATA PROCESSING TECHNIQUE OF PPM/PPK WITHOUT THE REFERENCE PULSE." International Foundation for Telemetering, 1990. http://hdl.handle.net/10150/613478.
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International Telemetering Conference Proceedings / October 29-November 02, 1990 / Riviera Hotel and Convention Center, Las Vegas, NevadaThis paper describes the technical principle that signals conversion, data-processing and data storage are directly carried out without filling up with the reference pulse for PPM and PPK (pulse position keying). By means of analysis for typical frame structure of PPM/PPK signals, a variety of math models of signal time relationship of the system were found, and based on this, a engineering way and a principle block diagram for signals conversion, data processing and data storage were given out.
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Morel, Patrick. "Mécanismes de photo-oxydation de mélanges physiques PBT/PC - PPO/PA - PA/PP." Clermont-Ferrand 2, 1990. http://www.theses.fr/1990CLF21309.
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Les techniques expérimentales d'étude du comportement a long terme des matériaux polymères à partir de mesures réalisées en photovieillissement accéléré et en thermo-oxydation ont pu être exploitées pour des systèmes aussi complexes que des mélanges physiques. Dans de tels mélanges, les conjugaisons qui interviennent entre macro- et microphases ont été examinées. Dans le cas des mélanges PBT/C, la macrophase PBT/PC se comporte essentiellement comme un PBT pur alors que les microphases élastomères induisent une hydroperoxydation importante du PBT et de l'interphase entre nodules d'élastomères et la macrophase. Le système PPO/PA/élastomère diénique est le siège d'une photo-oxydation rapide et localisée dans les couches les plus superficielles. Le ppo est intrinsèquement le site le plus photo-oxydable du mélange ppo/pa et l'essentiel des photoproduits observes sont en fait des produits de photo-oxydation et de photolyse du PPO. Enfin, le mélange PA/PO est un exemple ou les deux constituants présentent des photo-oxydations conjuguées se traduisant par une formation plus rapide de photoproduits issus de la matrice polypropylène, les périodes d'induction généralement observées dans les polypropylènes homopolymères étant pratiquement éliminées dans les mélanges.
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Ferrando, Lebraud Haritz Eder. "Estudi de la viabilitat de la utilització de materials termoplàstics reciclats per a aplicacions en el sector de l'electrònica de consum." Doctoral thesis, Universitat Politècnica de Catalunya, 2007. http://hdl.handle.net/10803/6052.
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En els darrers anys ha augmentat de manera considerable l'interès de les empreses per l'ús de materials reciclats per a la fabricació dels seus productes. Les raons principals són l'estalvi econòmic que comporta a causa del progressiu increment del preu de la matèria primera i l'aposta per una política ambiental d'empresa, com a part de la seva responsabilitat social corporativa, en sintonia amb una sensibilitat creixent en l'opinió pública.Aquesta tesi s'ha centrat en l'estudi de la viabilitat de la utilització de materials termoplàstics reciclats per a aplicacions en el sector de l'electrònica de consum. En una primera part, s'ha estudiat la viabilitat de la substitució dels materials verges poliestirè antixoc (HIPS) i la mescla de polímers poli(èter de fenilè) amb poliestirè antixoc (PPE/HIPS) pels mateixos materials d'origen reciclat, procedents de residus industrials.
En una segona part, s'ha estudiat la viabilitat de substitució dels mateixos materials verges, estudiats en la primera part, per un material reciclat diferent. Aquest material reciclat ha estat el poli(tereftalat d'etilè)(PET) provinent de la recollida selectiva d'envasos de begudes postconsum.
El treball de recerca ha estudiat la variació de propietats mecàniques i tèrmiques dels materials reciclats de partida i de les mescles de material verge i reciclat, els efectes de la degradació provocats pels processos successius de transformació i la influència de càrregues minerals (fibres i microesferes de vidre) i ignifugants a base de fòsfor lliures d'halògens sobre les propietats dels materials.
L'estudi realitzat sobre aquests tres materials reciclats ha permès analitzar els factors que intervenen en l'estudi de materials reciclats, conèixer-ne les possibilitats d'aplicació en el cas concret de components d'electrònica de consum i crear les bases per poder establir una metodologia per realitzar futurs estudis d'introducció de materials reciclats en altres aplicacions tecnològiques.
En los últimos años ha aumentado de manera considerable el interés de las empresas por el uso de materiales reciclados para la fabricación de sus productos. Las razones principales son el ahorro económico que conlleva a causa del progresivo incremento del precio de la materia prima y la apuesta por una política medioambiental de empresa, como parte de su responsabililidad social corporativa, en sintonía con una sensibilidad creciente en la opinión pública.
Esta tesis se ha centrado en el estudio de la viabilidad de la utilización de materiales termoplásticos reciclados para aplicaciones en el sector de la electrónica de consumo. En una primera parte, se ha estudiado la viabilidad de la sustitución de los materiales vírgenes poliestireno antichoque (HIPS) y la mezcla de polímeros poli(éter de fenileno) con poliestireno antichoque (PPE/HIPS) por los mismos materiales de origen reciclado, procedentes de residuos industriales. En una segunda parte, se ha estudiado la viabilidad de sustitución de los mismos materiales vírgenes, estudiados en la primera parte, por un material reciclado diferente. Este material reciclado ha sido el poli(tereftalato de etileno) (PET) procedente de la recogida selectiva de envases de bebidas postconsumo.
El trabajo de investigación ha estudiado la variación de propiedades mecánicas y térmicas de los materiales reciclados de partida y de las mezclas de material virgen y reciclado, los efectos de la degradación provocados por los procesos sucesivos de transformación y la influencia de cargas minerales (fibras y microesferas de vidrio) y ignifugantes a base de fósforo libres de halógenos sobre las propiedades de los materiales.
El estudio realizado sobre estos tres materiales reciclados ha permitido analizar los factores que intervienen en el estudio de materiales reciclados, conocer las posibilidades de su aplicación en el caso concreto de componentes de electrónica de consumo y crear las bases para poder establecer una metodología para realizar futuros estudios de introducción de materiales reciclados en otras aplicaciones tecnológicas.
In recent years the interest of companies in the use of recycled materials for the manufacture of their products has increased considerably. The main reasons for this are, firstly, the economic savings offered when compared to the progressive increase in the price of the raw material and secondly, the pressure for a company to implement an environmental policy, as part of its 'corporate social responsibility', in tune with a growing sensitivity of public opinion in this area.
This thesis has focussed on studying the feasibility of the use of recycled thermoplastic materials for applications in the consumer electronics sector. In the first part, it centres on the feasibility of the substitution of the virgin materials High-Impact Polystyrene (HIPS) and the mix of polymers poly(ether phenylene) with High-Impact Polystyrene (PPE/HIPS), for the same materials of recycled origin, coming from industrial waste. In the second part, it studies the feasibility of substitution of the virgin materials studied in the first part, by a different recycled material. This recycled material being the pol (ethylene terephtalat) (PET) which comes from the selective collection of post consumption drink bottles.
The research work has studied the variation of mechanical and thermal properties of the original recycled materials and of the mixtures of virgin and recycled material, the effects of the degradation provoked by the successive transformation processes and the influence of mineral fillers (fibres and glass beads) and halogen-free phosphor-based flame retardants, on the properties of the materials.
The study, carried out on these three recycled materials, has allowed the following: analysis of the factors that intervene in the investigation of recycled materials; knowledge regarding the possibilities of application in the case of household electronics components and it has created the bases for being able to establish a methodology for carrying out future studies on the introduction of recycled materials in other technological applications.
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Akhimie, Regina Nicole. "Investigation of Rh2(II,II) complexes for applications in photochemotherapy and mismatch detection." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1511892689942643.
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Mnyani, Siphokazi. "Optimising benefits for rural communities in and around Protected Areas through ecotourism Public Private Partnerships (PPPs): the case of De Hoop Nature Reserve." University of the Western Cape, 2019. http://hdl.handle.net/11394/7416.
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Magister Artium - MARecent years have seen an upsurge of interest from governments and development organisations in adopting the Public Private Partnership (PPP) approach when developing and operating ecotourism projects. A PPP is a contract between a public sector institution and a private party, in which the private party assumes substantial financial, technical and operational risk in the design, financing, building and operation of a project (South African National Treasury 2004). Countries such as India, China and Kenya have developed numerous projects through PPPs. Protected Areas have followed suit in adopting the PPP approach, to be able to focus on their core business, namely conservation. To date, relevant research on PPP ecotourism projects, specifically pro-poor tourism approach is fragmented, limited in scope, and lacks examples that can assist practitioners in embedding pro-poor tourism principles in the PPP methodology. Academically, studies are largely evaluations that compare progress against projects’ defined objectives or broad based sustainable tourism goals. However, this study is an assessment of a tourism development from a pro-poor tourism perspective. Thus, this study interrogated the extent to which ecotourism PPP at De Hoop is pro-poor. Furthermore, the study sought to establish if rural local communities living in and near De Hoop PPP benefit and how their benefits can be enhanced. Pro-poor tourism indicators are used in this study as a theoretical base to evaluate De Hoop PPP.
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Lau, Wing Yin. "Pain assessment and possible mechanism of delayed onset muscle soreness." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2014. https://ro.ecu.edu.au/theses/1275.
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Muscle pain is felt during exercise or daily activities for several days after performing unaccustomed exercise, which is referred to as delayed onset muscle soreness (DOMS). Many people experience DOMS, but its underlying mechanisms are not fully understood. One of the challenges in the investigation of DOMS is its subjective nature, which makes the assessment ambiguous, thus establishing a standardised protocol is necessary. The present thesis scrutinised muscle pain assessments (Study 1, Study 2), developed a new assessment of muscle pain focusing on muscle fascia (Study 3), and investigated why DOMS is reduced after the second than the first bout of eccentric exercise (Study 4). From these studies, DOMS was thought to be more associated with connective tissue than muscle fibre damage and inflammation.
In Study 1, the relationship between pain level assessed by a visual analogue scale (VAS) and pain sensitivity assessed by pressure pain threshold (PPT) was examined. Thirty-one healthy young men performed 10 sets of 6 maximal isokinetic eccentric contractions with their non-dominant arm. Before and 1 - 4 days after the exercise, muscle pain perceived upon palpation of the biceps brachii at three sites (5, 9, and 13 cm above the elbow crease) was assessed by VAS with a 100 mm line (0 = no pain, 100 = extremely painful), and PPT of the same sites was determined by an algometer. The VAS increased after exercise and peaked two days post-exercise, while the PPT decreased most at 1 day post-exercise and did not return to baseline for 4 days following exercise (P
Muscle pain induced by elbow flexor eccentric exercise was investigated using different assessments in Study 2. Ten untrained men performed 10 sets of 6 maximal isokinetic eccentric contractions of the elbow flexors with one arm. Maximal voluntary isometric contraction torque (MVC), range of motion (ROM) and serum creatine kinase (CK) activity were measured before, immediately after, and 1 to 5 days after exercise as indirect markers of muscle damage. PPT of 50 sites over an exercised upper arm, VAS with a 100-mm line for pain level upon static pressure by a cuff and fingers, and palpation of the biceps brachii at three sites (3, 9, and 15 cm above the elbow crease) and different palpation methods (longitudinal, transverse and circular movements) on the mid-belly of biceps were assessed. Large decreases in MVC and ROM, and significant increases in serum CK activity indicated muscle damage. A significant difference (P
In Study 3, changes in the electrical pain threshold (EPT) of the biceps brachii fascia, biceps brachii muscle and brachialis fascia following eccentric elbow flexor contractions, and the relationship between EPT and VAS or PPT were investigated. Ten healthy untrained men performed two eccentric exercise bouts (ECC1, ECC2) consisting of 10 sets of 6 maximal isokinetic eccentric contractions of the elbow flexors with the same arm separated by 4 weeks. Changes in MVC, ROM, VAS and PPT were smaller (P
The purpose of Study 4 was to investigate the magnitude of muscle lengthening during the first and second bout of eccentric exercise bouts and whether the muscle length changes are associated with the magnitude of DOMS and changes in other indirect markers of muscle damages between bouts. Ten healthy untrained men performed two eccentric exercise bouts (ECC1, ECC2) consisting of 10 sets of 6 maximal isokinetic eccentric contractions of the elbow flexors using the same arm separated by 4 weeks. Changes in MVC, ROM, muscle thickness, ultrasound echo intensity, serum CK activity and muscle soreness (VAS) were smaller (P
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Pahl, Christoph [Verfasser]. "Adsorptive Wasserentfernung im unteren ppm- und ppb-Bereich zur Erzeugung hochreiner organischer Lösungsmittel / Christoph Pahl." Aachen : Shaker, 2012. http://d-nb.info/1069049573/34.
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Canot, Clotilde. "Détecteur optique Cherenkov de photons 511 keV, rapide et efficace, pour l’imagerie TEP." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS190/document.
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La Tomographie par Emission de Positrons (TEP) est une technique d’imagerie médicale utilisée largement dans le traitement du cancer et dans la recherche neurobiologique, afin d’imager l’activité biologique des organes. Il s’agit de détecter deux photons de 511 keV produits par l’annihilation d’un positron dans les tissus, ce qui permet d’en reconstruire la carte 3D. En mesurant avec une très bonne précision la différence de temps de détection des deux photons, il sera possible d’améliorer la qualité d’image (technique du temps de vol). Dans ce manuscrit, nous présentons le développement de deux détecteurs innovants, rapides et efficaces, pour la détection de la lumière Cherenkov produite par la conversion des photons de 511 keV. Le premier, destiné à un scanner clinique (cerveau) et pré-clinique à haute précision spatiale, utilise comme milieu de détection du TriMéthylBismuth. Le second, pouvant être utilisé pour construire un scanner corps entier, met en œuvre un cristal de PbF₂ comme radiateur Cherenkov. Dans les deux configurations, un photomultiplicateur à micro-canaux (MCP-PMT) est utilisé pour détecter les photons Cherenkov. Notre électronique de détection montre une résolution temporelle limitée à 5 ps (RMS). La chaîne de détection est limitée par les performances du MCP-PMT. Après étalonnage, nous avons mesuré une efficacité de 25 % (grande pour un détecteur Cherenkov), et de résolution temporelle de 200 ps (FWHM).Nous exposons les facteurs limitant la résolution temporelle des détecteurs et proposons des développements qui permettront d’en améliorer les performancesPositron Emission Tomography (PET) is a nuclear imaging technique widely used in oncology and neuroscience to observe biological activity in the body. Detection of two gamma quanta with the energy 511 keV emitted by positron annihilation in tissues allows one to reconstruct the tracer activity distribution in the body of the patient. Additional measurement of the difference in time detection between the two photons lets us to improve significantly the quality of the reconstructed image (time-of-flight method).In this manuscript, we present the development of two innovative detectors, fast and efficient, used to detect Cherenkov light produced by electrons from the photo-ionization conversions of 511 keV gamma quanta. The first one, intended for use in a brain PET scanner of a high spatial resolution, uses TriMethylBismuth for the detection medium. The second one, planned to be used to construct a whole-body PET scanner, enforces a PbF₂ crystal as Cherenkov radiator. In both configurations a micro-channel photo-multiplier (MCP-PMT) is used to detect Cherenkov photons. We commissioned an electronic detection chain with a time resolution limited to 5 ps (RMS). Using precise MCP-PMT calibration, we were able to develop simultaneously detectors with high efficiency, up to 25 %, and time resolution as good as 200 ps (FWHM).We highlight the limitations of detectors time resolution and suggest several developments in order to improve performances of Cherenkov light detectors
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Cheng, Wing-Shing. "TARP Promoter-Based Prostate Cancer Gene Therapy : From Development to Application." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5736.
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Byrne, Lawrence Thomas. "Langmuir probe measurements in the plume of a pulsed plasma thruster." Link to electronic thesis, 2002. http://www.wpi.edu/Pubs/ETD/Available/etd-1219102-173938.
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Thesis (M.S.)--Worcester Polytechnic Institute.Keywords: PPT; pulsed plasma thruster; Langmuir probe; plasma diagnostics; electric propulsion; electron temperature; electron density. Includes bibliographical references (p. 97-102).
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Shakeri, Eghbal. "An investigation of privately promoted infrastructure (PPI) strategy in developing countries : public-private partnership (PPP) approach." Thesis, University of Manchester, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488188.
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Kang, Jiho. "Electrochemical studies of coatings and thin films." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1138388240.
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Wilhelmsson, Emelie. "3D-positionering till havs efter bearbetning med PPK- och PPP-lösning och kontroll av fartygets dynamiska rörelser." Thesis, Stockholms universitet, Institutionen för naturgeografi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-150152.
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This project investigates whether 3D-positioning at sea can be improved by processing real-time positioning data. SWEPOS-based RTK (accurate GNSS) was used to log positions data on a hydrographic survey vessel along Sweden’s east and north coast for 7 days. However, because of the long distance between the vessel and the reference stations the positioning solutions do not always have high accuracy. This problem generates a large interest to research how processing real-time data could improve position accuracy. Processing positioning data is done through Applanix IN-fusion PPK (Post-Processed Kinematic) and PPP (Precise Point Positioning) loosely coupled concept. The positioning accuracy of these methods are compared against one another and against collected data in real-time (RTK). The vertical component are being assessed further in detail to evaluate the accuracy of these methods and the data is presented in respect to vertical positioning and height. However, solely processing the vessels positioning according to the PPP or PPK concept is not enough to get a good positioning vertically, as the vessels positioning height also depends on the vessels dynamic movements. Including the vessel’s dynamic movement’s leads not only to a higher positioning accuracy but also to a more accurate description of the shape of the water surface. The shape of the water surface is an important component for the modelling of the geoid, as the water mass distribution affects gravitational measurements and calculations by water mass variations. The future goal, is that vessels should be able to collect data which can be used to correct the present geoid model, only by using GNSS technique and water level corrections from reference stations. Furthermore, good hydrographic data and accurate GNSS height provides preconditions to introduce a 3D-navigational system. A system like this could calculate if the present draught is compatible with the future depth conditions along the route. The system can thereby support the navigator with suggestions of speed adjustments at optimal moments to avoid running aground. Initially, the different post-processing methodology’s ability to improve position accuracy are evaluated. The observations presented in this project indicate that position accuracy varies depending on which method is used. The results show that the vertical measurement uncertainty (RMS) values are lowest when using the processing methods based on the PPK concept. The RMS mean value using PPP processing methodology show a higher value than the real-time solutions. In this case, by adjusting the real-time solutions by processing according to the PPK method, the vessels vertical position can be corrected with a mean value of 5 cm. In the secondary process, the GNSS height from the PPK processing methodology was used together with static and dynamic corrections to approximate the actual water level. This project demonstrates the potential of using this type of process to get a more accurate picture of the present water surface.
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Ferreira, Elys Raquel Andrade. "Filmes de polipirrol como matrizes para a imobilização da polifenol oxidase e aplicação como biossensores amperométricos na análise de compostos fenólicos." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/88/88131/tde-01122014-112608/.
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Nesta dissertação, a polifenol oxidase (PFO) como extrato bruto de abacate (Persea americana) foi imobilizada em filmes de polipirrol (PPI) sintetizados eletroquimicamente utilizando o glutaraldeído (GA) como um agente de ligação entrecruzada. Os filmes PPI e PPI/PFO-GA foram caracterizados por eletroquímica, principalmente voltametria cíclica, sendo avaliadas a eletroatividade e a reversibilidade eletroquímica. A detecção de compostos fenólicos em soluções padrão foi feita por cronoamperometria, tendo um controle sobre a concentração dos compostos. O processo de transferência de massa foi monitorado com uma microbalança de cristal de quartzo eletroquímica. Os resultados indicaram uma boa reprodutibilidade das medidas na detecção dos compostos fenólicos. A estabilidade do biossensor em uma solução tampão manteve-se durante 27 dias, um resultado aceitável já que é encontrado na literatura um tempo de vida estável para sistemas semelhantes em tomo de 30 diasIn this dissertation, polyphenol oxidase (PPO) as crude extract of avocado (Persea americana) was immobilized on electrochemical1y synthesized polypyrrole (PPY) films using glutaraldehyde (GA) as a crosslinking agent. PPY and PPY/PPO-GA films were electrochemical1y characterized, mainly by cyclic voltametry, where electroactivity and electrochemical reversibility were evaluated. The detection of phenolic compounds in standard samples was made by chronoamperometry with a control over the compound concentration. The process of mass transfer was monitored with an electrochemical quartz crystal microbalance (EQCM). Our results indicated a good repeatability of the measurements for the detection of phenolic compounds. The stability of biosensor in a buffer solution has remained for 27 days, a result acceptable since it is found in the literature a time of life stable for similar systems around 30 days
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Smith, Rachel. "Towards the synthesis of multifunctional constructs : coupling PET and PDT for the targeted diagnosis and therapy of CXCR4 expressing tumours." Thesis, University of Hull, 2012. http://hydra.hull.ac.uk/resources/hull:16087.
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To establish accurate and early stage tumour diagnosis, quantitative molecular imaging modalities such as positron emission tomography (PET) are being employed. Molecular probes containing a positron emitting isotope (e.g. ¹⁸F, ⁶⁴Cu) are designed to target biomarkers or metabolic processes within the tumour. A therapeutic molecule could then be conjugated to this diagnostic probe to create a multifunctional construct (MFC). MFCs are a new concept in drug design offering the potential for both diagnosis and therapy. This work exploits the chelating properties of saturated tetraazamacrocycles known herein as macrocycles as well as their known affinity for the chemokine receptor CXCR4, a cell surface receptor involved in embryonic development and cell migration known to be overexpressed in at least twenty three different tumour types, along with the photodynamic activity of porphyrin molecules to create novel MFCs with diagnostic and therapeutic properties. A series of configurationally restricted copper(II), zinc(II) and nickel(II) mono-ring macrocycles bearing a methylamine pendant arm are presented. Monomacrocycles possess the potential for improved pharmacological properties. Biological studies assessing the affinity and potency of these macrocycles as CXCR4 antagonists demonstrated that zinc(II) monomacrocycles were the most potent in their class. A side bridged (SB) zinc(II) monocyclen compound; [Zn9]²⁺ synthesised in 64% yield, demonstrated the highest affinity for CXCR4 in its class showing a 2.5-fold higher affinity in comparison to the clinically licensed antagonist AMD3100 (IC₅₀ = 12 nM vs. 31 nM). In response to the high affinity observed for a meta-substituted biscyclen ligand (L48) a novel cross bridged (CB) meta-substituted biscyclen compound bearing a methylamine pendant arm 20 was synthesised along with its copper(II), nickel(II) and zinc(II) complexes in 77%, 88% and 90% yields, respectively. These metal complexes displayed high affinity for CXCR4 when competed with a CXCR4 specific antibody (% inhibition >85%) and required sub-micromolar concentrations to reduce the ‘normal’ signalling of CXCR4 by 50%. [Cu₂20]⁴⁺ has the potential to be a targeted PET probe through the use of ⁶⁴Cu and so a detailed biological evaluation into its binding mode was undertaken. These assays concluded that [Cu₂20]⁴⁺ exerts its antagonistic effect by locking the receptor on the surface of the cell, stopping the internalisation and recycling processes, which would result in formation of a new receptor. An analogous meta-substituted biscyclam ligand (28) and its copper(II), zinc(II) and nickel(II) complexes were synthesised in 74%, 58% and 46% yields, respectively. These metal complexes also demonstrated high affinity for CXCR4 (IC₅₀ < 0.1 μM). In fact [Cu₂28]⁴+ showed unexpectedly high affinity for CXCR4 demonstrating almost a 3-fold higher affinity than AMD3100 (IC₅₀ = 11nM vs. 31 nM), the potential of [Cu₂28]⁴⁺ as a targeted PET probe should also be considered. Various organic spacer arms were attached to bismacrocycle 20, to produce a CXCR4 targeting probe with a functional arm for further conjugation which would also act to prevent steric hindrance. An acidic terminating chain was successfully attached to bismacrocycle 20 in quantitative yield, via ring-opening of diglycolic anhydride as well as an amine terminating variant (93% yield). A biotin tag was also attached to bimacrocycle 20 and its copper(II) complex was successfully isolated in a 94% yield. Addition of a spacer arm was found to have no significantly detrimental effect on binding affinity to CXCR4. A series of known water and organic soluble metalloporphyrins were synthesised. Subsequent conjugation to macrocyclic compounds proved challenging but analytical data for the conjugation of bismacrocycle 20 and metalloporphyrin [Zn59] indicated a successful reaction had occurred. This reaction represents important steps towards the synthesis of MFCs with diagnostic and therapeutic properties.
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Seman, Vladimír. "Analýza PPC systémů při různých PPC kampaních." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-15459.
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Pay per click (PPC) advertising over the past few years has gained importance and companies invest larger amounts of money into it. There are more PPC systems in the market from which to choose for advertising. Which PPC system is appropriate to use for a specific campaign? This thesis consists of four chapters (excluding introduction and conclusion). The first chapter clarifies terms, talks about the basic characteristics of the subject and gives an idea of the importance of the topic (position of pay per click in the market of internet advertising). The second chapter characterizes three PPC systems (and their principles) which the author considers to be the most important in the Slovak market. The third chapter is important for the characterisation of different types of PPC campaigns. In it the author used his own classification of PPC campaigns. Two case studies are analysed in the fourth chapter. According to them an evaluation of the suitability of selected PPC systems is made (using induction method). The first three chapters are based on an analysis of available literature, the fourth part on the author's own experiences.
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Barros, Arielle Muniz de. "Bioadsorção e dessorção dos íons 'Cd POT. 2+', 'Cu POT. 2+' , 'Ni POT. 2+', 'Pb POT. 2+' e 'Zn POT. 2+' pela macrófita aquáica Azolla pinnata." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/266685.
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Orientadores: Meuris Gurgel Carlos da Silva, Sirlei Jaiana KleinübingDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Química
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Resumo: Pesquisas no campo da tecnologia têm buscado avaliar técnicas e/ou processos econômicos e eficientes para o tratamento de efluentes que contenham metal pesado. Atualmente a bioadsorção vem se apresentando como uma boa alternativa às tecnologias existentes. Este trabalho teve como objetivo a investigação da macrófita Azolla pinnata como bioadsorvente de cinco íons metálicos: Cd2+, Cu2+, Ni2+, Pb2+ e Zn2+ em soluções sintéticas. A caracterização do biomaterial foi realizada utilizando-se técnicas como Microscopia Eletrônica de Varredura (MEV) para análise da superfície do material; análise de Espectroscopia de Energia Dispersiva de Raios-X (EDX), que mostrou que qualitativamente a diminuição de íons de competição (Ca, Na e K) após o processo de adsorção, evidenciando que a troca iônica pode ser um dos mecanismos do processo; e análise de Infravermelho por Transformada de Fourier (FTIR), em que se pôde constatar que alguns grupos funcionais como carboxilas e grupos sulfonados são fundamentais no processo. A cinética de adsorção foi ajustada pelos modelos de pseudoprimeira e pseudossegunda ordem, sendo que o melhor ajuste variou de acordo com o íon estudado. O modelo de difusão intrapartícula mostrou que muitos mecanismos podem ser limitantes na taxa com a qual ocorre o processo. Os dados de equilíbrio foi ajustado pelos modelos de isoterma de Langmuir e de Freundlich em duas temperaturas, 25 e 45 ºC. O processo foi favorecido pelo acréscimo de temperatura para todos os íons. O modelo de Langmuir se ajustou melhor aos dados experimentais de todos os íons e o valor de capacidade máxima de adsorção (qmax) a 25 ºC foi de 0,359; 0,448; 0,254; 0,472 e 0,357 mmol/g para Cd2+, Cu2+, Ni2+, Pb2+ e Zn2+, respectivamente. Os eluentes HCl, EDTA e CaCl2 foram testados no processo de dessorção em batelada e o cloreto de cálcio se mostrou eficiente além de não causar danos ao material nem diminuir a capacidade de adsorção da macrófita. Ensaios dinâmicos em coluna de leito fixo foram realiados para os íons Cu2+ e Pb2+ com soluções mono e bicomponentes. Nos ensaios em sistema binários, pode-se constatar uma grande preferência pela adsorção de íons chumbo e, portanto, uma grande queda na adsorção de cobre. Foram testados ciclos de adsorção/dessorção em coluna utilizando o CaCl2 como eluente e, em três ciclos, a macrófita manteve suas propriedades adsortivas. Com estes resultados, pode-se constatar que a realização deste trabalho contribuiu para a avaliação deste material como bioadsorvente alternativo e que, especificamente, macrófita A. pinnata mostrou-se atrativa para utilização nos processos de tratamento e/ou estabilização de metais pesados presentes em baixas concentrações em efluentes industriais
Resumo: No processo Kraft para produção de papel e celulose, os cavacos de madeira são cozidos em um digestor com uma solução aquosa denominada licor branco, constituída de hidróxido de sódio (NaOH) e sulfeto de sódio (Na2S). Durante o cozimento uma pasta fibrosa é produzida. Esta pasta é filtrada e segue para o branqueamento. O produto filtrado chama-se licor negro, devido à mudança da sua cor nesta etapa. O licor negro possui aproximadamente 15 % de sólidos em massa. Ele é bombeado para a unidade de recuperação, na qual ele será concentrado em evaporadores de múltiplosefeitos até 75 % de sólidos em massa. Em seguida, ele é bombeado para uma caldeira onde é queimado, para recuperar os sais inorgânicos e, principalmente, fornecer calor para geração de calor. Durante a evaporação do licor negro, quando a porcentagem em sólidos ultrapassa 50 %, ocorre a precipitação de sais inorgânicos. Estes sais se depositam nas superfícies de troca térmica dos evaporadores diminuindo sua eficiência e causando prejuízos à indústria. Os principais sais que causam este problema são o carbonato de sódio (Na2CO3) e o sulfato de sódio (Na2SO4). O objetivo do presente trabalho foi testar e validar um método experimental para a determinação da quantidade de Na2CO3 presente em amostras industriais de licor negro. Além disso, também foram analisadas algumas propriedades físico-químicas do licor negro, como massa específica, teor de sólidos e viscosidade. Com os resultados obtidos, tentou-se obter uma correlação entre o teor de carbonato de sódio e as demais propriedades do licor que foram determinadas. Os resultados das análises das características físico-químicas demonstraram coerência e boa reprodutibilidade, porém, os resultados das análises de teor de carbonato de sódio não foram satisfatórios e mostraram que a técnica deve ser aperfeiçoada
Abstract: Research in the technology field has been looking for evaluating efficient and economic techniques and/or process for effluents that contains heavy metal. The biodsorption process has been seemed as a good alternative to the existing technology. This work had the aim to investigate the use of Azolla pinnata macrophyte as biosorbent of five metallic ions: Cd2+, Cu2+, Ni2+, Pb2+ and Zn2+ in synthetic solutions. The biomaterial characterization was carried out by techniques as scanning electron microscopy (SEM) for the analyze of material superficies; the energy dispersive X-ray spectroscopy (EDX), which showed, qualitatively, a decreasing in the competitions ions (Ca, Na e K) after the sorption process, indicating that the ion exchange can be one o the process mechanism; and Fourier Transform Infrared Spectroscopy (FTIR), in which it was possible implied functional groups as carboxyl and sulfonate play a important role in the adsorption. The kinetics was adjusted by primer and second order models and the model which fit better depends on each ion. The intra-particle diffusion model showed that several mechanisms may be limiting to the process rate. The equilibrium data were adjusted by Langmuir and Freundlich models in two temperatures: 25 and 45 ºC. The process was favored by the increasing in the temperature for all five ions. The Langmuir model fit better the experimental data and the maximum adsorption capacity (qmax) were 0,359; 0,448; 0,254; 0,472 and 0,357 mmol/g for Cd2+, Cu2+, Ni2+, Pb2+ and Zn2+, respectively. The HCl, EDTA and CaCl2 eluents were tested in the desorption process and the calcium chloride was efficient and did not cause any damage in the biomaterial or decreasing the biosorption capacity. Dynamics runs were carried out in fixed-bed in mono and bi-components solutions. In the binary were found a great preference for lead instead of copper and as a result, a significant decrease in the removal of copper. Adsorption/desorption cycles were tested in fixed-bed system using CaCl2 as eluent. After three cycles no damage, weight lost or significant decrease in the biosorption capacity was noticed. These results indicating that the A.pinnata macrophyte is an attractive potential new biosorbent to be used in heavy metal removal especially in low concentrations effluents
Abstract: In the Kraft process for pulp and paper production, wood chips are cooked in a digester with an aqueous solution named white liquor, consisted by sodium hydroxide (NaOH) and sodium sulfide (Na2S). During this cooking process, wood chips are transformed generating a fibrous paste and a liquid solution. This paste is filtered and separated from the liquid solution, named black liquor due to its color. The paste goes to the bleaching stage to produce cellulose. Black liquor contains inorganic and organic (mainly lignin) compounds from wood. Initially this black liquor contains approximately 15 mass/% of solids and is sent to the recovery unit to have this concentration raised to approximately 75 mass/% to be burned in a recovery boiler in order to generate power and recover inorganic reactants, recycling them to the process. The concentration process of black liquor occurs in a multiple effect evaporators unit. During this process, when the concentration of solids exceeds 50%, the precipitation of inorganic salts (mainly Na2CO3 and Na2SO4) begins. These salts are deposited in the heat transfer surfaces of the evaporator tubes, reducing their efficiency, leading to a reduction in the production capacity. The scope of this work was testing and validate an experimental method to estimate the content of Na2CO3 present in industrial black liquor samples. Moreover, some black liquor's physical-chemical properties as density, solids content and viscosity were also analyzed. An attempt to develop a predictive model to evaluate sodium carbonate content from the other properties was made. The results obtained for physical-chemical properties have shown a good consistency. However, the results of sodium carbonate analyses were not satisfactory, showing that the technique must be improved
Mestrado
Engenharia de Processos
Mestra em Engenharia Química
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Martel, Bernuy Gianella Darlen, Niquen Dario Massa, Chávez Fiorella Francesca Olcese, and Vizarreta Alison Gloria Ramirez. "Safe Pet." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2020. http://hdl.handle.net/10757/655746.
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Este trabajo de investigación nace por el amor a nuestras mascotas, el querer darles una mejor calidad de vida y la necesidad que tenemos los dueños de mascotas de tener una atención inmediata y de calidad para nuestros amigos peludos cuando pase alguna emergencia. De esa necesidad es que nace el seguro para mascotas SAFE PET, que ofrece un paquete estándar que incluyan varios beneficios y coberturas para las mascotas afiliadas.
La principal fuente de ingreso de SAFE PET será la venta de nuestras pólizas, nuestra inversión inicial será de s/ 124,890 que la financiaremos el 60% los 4 socios de la empresa y 40% con un préstamo a una entidad financiera.
Por las investigaciones que realizamos mediante encuestas a dueños de mascotas, estos en su mayoría nos manifestaba el querer tener un seguro para su mascota, y luego gracias nuestra landing page pudimos observar que del 100% de visitas a nuestra landing el 54.6% dejó sus datos porque le interesa nuestro seguro, este porcentaje es mucho mayor al que esperábamos y eso nos alienta mucho más a ser uno de los primero en el país en dedicarnos exclusivamente en seguro integral de mascotas.
Finalmente, luego del estudio financiero realizado a nuestra empresa hemos considerado en el análisis de sensibilidad COK (89.71%) y un costo promedio ponderado de capital de WACC (74.53%), para terminar después de todo nuestro plan financiero podemos concluir que SAFE PET, es una empresa viable económicamente.This research was born for our love to pets and we want to give them a better life quality and the need that pet owners to have immediate and quality care for our furry friends when an emergency happens. From that need is born SAFE PET, that is a pet insurance, which offers a standard package that includes many benefits and coverages for affiliated pets. The main source of income for SAFE PET will be the sale of our policies, our initial investment will be S/ 124,890 which will be financed by 60% the 4 partners of the company and 40% with a loan to a financial institution. Due to the research we conducted through surveys of pet owners, most of them told us that they wanted to have insurance for their pet, and then thanks to our landing page we could observe that of 100% of visits to our landing, 54.6% left their data Because you are interested in our insurance, that percentage is much higher than we expected and that encourages us much more to be one of the first in the country to dedicate ourselves exclusively to comprehensive pet insurance. Finally, after the financial study carried out on our company, we have considered in the sensitivity analysis COK (89.71%) and a weighted average cost of capital of WACC (74.53%), to finish after all our financial plan we can conclude that SAFE PET, it is an economically viable company.
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Leon, Gómez Gabriela, Zegarra Speedy Jason Gomez, Arellano Kiara Yolanda Gutierrez, Grados Laura Viviana Olaya, and Huyhua Ricardo Augusto Toralba. "Pet Safe." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2019. http://hdl.handle.net/10757/653907.
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El presente trabajo plantea la puesta en marcha de un negocio innovador, para ello, se ha considerado los factores externos e internos que podrían repercutir en el desarrollo del mismo. Asimismo, se ha evaluado el contexto actual y se ha elaborado el respectivo estudio que sustenta la viabilidad del proyecto.
Hoy en día las personas se preocupan más por la seguridad de sus mascotas, existe una tendencia petfriendly que ha llevado a la sociedad a incrementar el consumo de alimentos balanceados, gastos en veterinarias y spas caninos.
Considerando que no existe en la actualidad un negocio similar al planteado, los alumnos autores del presente trabajo han considerado que la creación de un seguro para mascotas en el Perú sería altamente rentable.
Para sustentar la idea expuesta, se ha tomado en consideración todos los aspectos concernientes a la creación de la persona jurídica, los objetivos estratégicos, políticas internas y externas, análisis financieros y la rentabilidad del proyecto.
Después de analizar los aspectos antes mencionados, y de considerar todos los aspectos que puedan influir en su desarrollo, se llega a la conclusión de que el negocio es viable.This work proposes the start-up of an innovative business, for this, the external and internal factors that could have an impact on its development have been considered. Likewise, the current context has been evaluated and the respective study that supports the viability of the project has been prepared. Nowadays people care more about the safety of their pets, there is a petfriendly trend that has led society to increase consumption of feed, veterinary expenses and canine spas. Considering that there is currently no business similar to that proposed, the student authors of the present work have considered that the creation of pet insurance in Peru would be highly profitable. To support the idea presented, all aspects concerning the creation of the legal entity, strategic objectives, internal and external policies, financial analysis and the profitability of the project have been taken into consideration. After analyzing the aforementioned aspects, and considering all aspects that may influence its development, it is concluded that the business is viable.
Trabajo de investigación
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Cerrutti, Depaz Giannina Melitza, Huerta Nadya Fernández, Ortega Arturo Alejandro Salazar, and Cabrejos Mario Augusto Troya. "Pet Go." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/624821.
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Las mascotas tienen una influencia positiva en la salud y el bienestar de los seres humanos, por lo que hoy ocupan un lugar muy importante en los hogares de las familias, son considerados como un miembro más en la familia, independientemente del estrato cultural. Esta relación implica preocupación, temor entre otros riesgos que no solo causan tristeza en la familia, sino también en la misma mascota que sufre y pone en riesgo su salud que es necesario minimizar; aquí es donde nuestra idea contribuye a crear una identidad para las mascotas, a través de una placa con un código QR, que ofrece beneficios especialmente dirigidos a mejorar el cuidado de las mascotas y en caso de pérdida poder regresar a casa. Asimismo, contribuye a fortalecer la tenencia responsable de mascotas en los hogares de familia. Es necesario que el dueño conozca que en una era de constante crecimiento tecnológico puede llegar a tener un impacto positivo para la protección y beneficios a sus mascotas.Pets have a positive influence on the health and well-being of human beings, so today they occupy a very important place in the homes of families, they are considered as one more member in the family, regardless of the cultural stratum. This relationship implies concern, fear among other risks that not only cause sadness in the family, but also in the same pet that suffers and puts their health at risk that it is necessary to minimize; This is where our idea contributes to create an identity for pets, through a plate with a QR code, which offers benefits especially aimed at improving the care of pets and in case of loss to be able to return home. It also contributes to strengthening responsible pet ownership in family homes. It is necessary that the owner knows that in an era of constant technological growth can have a positive impact for the protection and benefits to their pets
Trabajo de investigación
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Ryusuke, Nakamoto. "Comparison of PET/CT with sequential PET/MRI using an MR-compatible mobile PET system." Kyoto University, 2018. http://hdl.handle.net/2433/232099.
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Diop, Bocar Noël. "Élaboration de nanoparticules hybrides multifonctionnelles à base de silice par microémulsion inverse : application à la conception d’un agent antibactérien." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10281/document.
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Cette thèse a pour objectif l’élaboration de nanoparticules hybrides à base de silice par microémulsion inverse. Les nanoparticules de silice constituent une matrice de base permettant de confiner et de protéger des molécules organiques et/ou des nanoparticules métalliques. L’incorporation combinée de différentes entités dans la silice ouvre ainsi de larges perspectives de par l'introduction de nouvelles propriétés liées à la structure hybride. Afin d’élaborer de tels objets, nous avons utilisé des micelles inverses à base d'eau, de Triton X-100, d'hexanol et de cyclohexane comme milieu réactionnel. L’influence des conditions opératoires sur le contrôle de la taille des micelles inverses a d'abord été étudiée. Ces micelles inverses ont ensuite été mises à profit comme nanoréacteurs pour la synthèse de nanoparticules de silice par procédé sol-gel en utilisant les précurseurs alkoxysilanes adéquats. Nous avons regardé dans quelle mesure il était possible de contrôler la taille des nanoparticules de silice en fonction du pourcentage d’eau par rapport au tensioactif. Il a ainsi été possible d’accéder de façon reproductible à des nanoparticules avec de tailles variables, de 30 nm à 200 nm. Nous avons ensuite regardé qu'il était possible d'encapsuler au sein de cette matrice nanométrique des fluorophores et des nanoparticules d’or et d’argent de façon contrôlée. En vue d’assurer une bonne stabilisation colloïdale en solution, ces nanoparticules hybrides ont été fonctionnalisées d'une part par ajout d'un silane fonctionnel et d'autre part par click chemistry. Nous avons ainsi pu montrer qu’il est possible d’effectuer dans un même milieu micellaire l’ensemble des processus de fabrication de la nanoparticule hybride, de la matrice de silice à sa fonctionnalisation en passant par l’incorporation d’entités fonctionnelles. Cette méthode de synthèse séquentielle nous a ainsi permis de supprimer les étapes de purification et de redispersion qui peuvent s’avérer problématiques dans les procédés classiques. L’ensemble de ce travail a été mis à profit pour la conception d’un agent antibactérien à base de nanoparticules argent/silice capables d’empêcher la prolifération bactérienne grâce au relargage progressif des ions argent. Les tests effectués en solution comme sur le coton et le polyéthylène téréphtalate imprégnés montrent effectivement un caractère antibactérien certain de ces systèmesThis thesis aims at developing hybrid nanoparticles based on silica by reverse microemulsion. The silica nanoparticles are the basic matrix containing and protecting organic molecules and/or metallic nanoparticles. The combined incorporation of different entities within the silica opens wide prospects for the introduction of new properties related to the hybrid structure. To develop such objects, we used reverse micelles based on water, Triton X-100, hexanol and cyclohexan as reaction medium. The influence of operating conditions on the control of the size of reverse micelles was first studied. These micelles were then set to be used as nanoreactors for the synthesis of silica nanoparticles by sol-gel using suitable alkoxysilanes precursors. We monitored how it was possible to control the size of silica nanoparticles based on the water to surfactant ratio. It was thus possible to prepare in a reproducible way nanoparticles with sizes varying from 30 nm to 200 nm. We then investigated the possibility to encapsulate, in this nanoscaled matrix, fluorophores and nanoparticles of gold and silver in a controlled manner. To ensure a good colloidal stability in solution, these hybrid nanoparticles were, on the one hand, modified by adding a functional silane and, on the other hand, by click chemistry. We have thus shown that it is possible to perform, in a same micellar media, all of manufacturing process of the hybrid nanoparticle, from the silica matrix to its functionalization passing by the incorporation of functional entities. This method of sequential synthesis allowed us to bypass the purification and redispersion steps that can be problematic in the conventional methods. All this work has been extended to the design of an antibacterial agent based of silver/silica nanoparticles, capable of preventing bacterial growth through the gradual release of silver ions. Tests conducted in solution on the impregnated cotton and polyethylene terephtalate indeed show an interesting antibacterial character of these systems
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Chonde, Daniel B. "Improved PET Data Quantification in Simultaneous PET/MR Neuroimaging." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467219.
Full textAbstract:
Recently, systems that integrate positron emission tomography and magnetic resonance imaging (PET/MR) have become available for clinical use. This new technology, which combines the high spatial resolution and superior soft-tissue contrast of MR with the picomolar sensitivity, quantitative capabilities, and wide array of tracers of PET, has the potential to benefit patients and provide insights that were previously unattainable in standalone systems. Simultaneous measurement of PET and MR parameters provides complementary information, allowing for a more complete assessment of disease, as well as cross validation and calibration of MR and PET measurements and techniques.
To take full advantage of such a multi-modal system, accurate quantification of the PET data is necessary. Due to the low spatial resolution of PET – which can be further reduced by external factors like patient motion – and the inherent lack of anatomic detail, accurate quantification can be challenging. The simultaneously acquired MR information provides an opportunity to optimize PET quantification and analysis. In order to fully realize the benefits provided by the simultaneously acquired MR data, the MR data cannot be treated as discrete sequences, but as the continuous flow of information. This is due to differences in the time required for data collection to generate PET and MR images.
This work describes the development and optimization of a pipeline for the reconstruction and analysis of PET data in a brain-dedicated prototype PET/MR system, the BrainPET (Siemens Healthcare). First, the performance of the BrainPET system was optimized for neurological imaging. MR-hardware interference and characteristics of the PET camera were quantified and a method for multimodal alignment was developed. To simplify and streamline the reconstruction and quantification process, a platform was designed which utilizes the functionality of a number of specialized brain imaging analysis software packages in an automated fashion. Second, MR-based methods addressing specific challenges to PET quantification were addressed. Simultaneously acquired structural MR data was used to correct the PET data for attenuation and partial volume effects. The use of MR data for motion correction was addressed and a unified algorithm which derives motion estimates from the PET data when MR data is unavailable was presented. Finally, the value of the optimized PET processing for neurological studies was evaluated in three instances: first an upper limit on the physiologic noise introduced by MR imaging on cerebral metabolism was estimated using PET and found to be minimal; next the benefit of MR-based motion correction and partial volume effect correction were estimated in a patient study; and lastly, a method to derive the PET radiotracer input function from the PET data using multiple MR sequences was presented.Biophysics