Journal articles: 'PR 2353'

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Rodriguez, Maria Alma, and Jane N. Winter. "Treatment Response to Single Agent Sphingosomal Vincristine in Patients with Relapsed and/or Refractory Diffuse Aggressive Non-Hodgkin’s Lymphoma (NHL): Subgroup Analyses." Blood 104, no. 11 (November 16, 2004): 2488. http://dx.doi.org/10.1182/blood.v104.11.2488.2488.

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Abstract There is a substantial need for new effective therapies for patients with recurrent or refractory diffuse aggressive NHL. Efficacy and safety of sphingosomal vincristine (SV), a novel formulation of vincristine encapsulated in sphingomyelin liposomes or ‘sphingosomes’, were evaluated in a multinational study in aggressive NHL patients with multiple unfavorable prognostic factors. Methods: 119 pts with relapsed or refractory aggressive NHL were enrolled. SV was administered at 2 mg/m2 without capping the dose as a 1 hr IV infusion every 2 weeks. The objective response rate (ORR) and 95% CI for the proportions and difference in proportions were calculated for the following subgroups: by age (≤ 60 vs. > 60); sensitive disease vs. resistant (refractory or relapsed within 3 months of prior treatment); IPI score 0–2 vs. 3–5; prior therapies 2 vs. >2; bone marrow involvement at baseline; and prior ABMT. Results: ORR in the entire group was 25% (7% CR/Cru and 18% PR) (ASH Abstr. 2353, 2003). No of Prior Regimens/Disease Sensitivity ORR % aone patient had 1 prior regimen Sensitive (n=39) Resistant (n=80) 41% 18% 2 Regimens (n=24)a -Sensitive (n=11) -Resistant (n=13) 46% 64% 31% >2 Regimens (n=95) -Sensitive (n=28) -Resistant (n=67) 20% 32% 15% Other Subgroup Analyses ORR % bnot statistically significant as 95% CI on the difference in ORR includes zero Bone Marrow Involved (n=20) Not involved (n=93) 10% 27% Ageb ≥60 (n=60) >60 (n=59) 25% 25% IPIb 0–2 (n=59) 3–5 (n=58) 19% 31% Prior ABMTb Yes (n=39) No (n=80) 26% 25% Conclusion: Single-agent SV was active in heavily pretreated patients with relapsed and/or refractory NHL. A multivariate analysis showed that the two strongest predictors for response were number of prior regimens and sensitivity to the last therapy. The highest level of activity was observed in patients with sensitive disease and 2 prior regimens (ORR 64%). Response to SV in older patients was the same as in younger patients. Prior ABMT did not impact response with ORR being similar in both groups. SV was well tolerated and the safety profile was similar to standard vincristine despite a doubling of dose intensity.

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Kasparavičius, Gediminas. "XIX a. pab. – XX a. pr. lietuviai verslininkai JAV." OIKOS: lietuvių migracijos ir diasporos studijos 28, no. 2 (2019): 21–47. http://dx.doi.org/10.7220/2351-6561.28.2.

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Kairaitytė, Aušra. "Folk Religion and the Cult of Saints in Lithuanian Rural Culture at the Beginning of the 21st Century." SOTER: Journal of Religious Science 54 (2015): 37–54. http://dx.doi.org/10.7220/2335-8785.54(82).3.

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Scha¨fer, U., J. Neukum, N. Bodenschatz, and J. Heber. "Up-conversion in Pr 3+ : CsCdBr 3." Journal of Luminescence 60-61 (April 1994): 633–35. http://dx.doi.org/10.1016/0022-2313(94)90236-4.

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Kim, Sun Il, and S. I. Yun. "Up-conversion in Pr 3+ -doped tellurite glasses." Journal of Luminescence 60-61 (April 1994): 233–36. http://dx.doi.org/10.1016/0022-2313(94)90138-4.

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Dwiana, Anna, and Lucky Herawaty. "FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PERILAKU BUANG AIR BESAR PADA MASYARAKAT DI DESA BANDAR BATAUGA KECAMATAN BATAUGA KABUPATEN BUTON SELATAN." Berita Kedokteran Masyarakat 33, no. 6 (June 1, 2017): 273. http://dx.doi.org/10.22146/bkm.23539.

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Determinants of defecation behavior among coastal community in district of South ButonPurposeThe purpose of this study was to identify the factors associated with community attitudes toward defecation in Bandar Batauga village Batauga district South Buton Regency.MethodsThis study used mixed methods, with convergent/concurrent design to merge the results of the quantitative and qualitative data analysis, their combination and contributions to the problem from multiple angles and multiple perspectives. The total number of respondents for this study were 110, divided into 100 respondents and 10 informants.ResultsChi-square analysis showed associated knowledge p-value = 0.0117; PR = 0.635 and facility availability p-value = 0.0002; PR = 1.876 with open defecation behavior.ConclusionTo improve the cooperation between health workers, heads of the environment, and communities need to provide more health education in order to increase the knowledge of the community and support the program of toilet procurement to support basic sanitation facilities.

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Fernandez-Morales, L. A., E. Dalmau, S. Martinez, A. Arcusa, C. Pericay, J. M. Lain, J. Font, L. Tortajada, E. Saigi, and M. A. Segui-Palmer. "Analysis of the pathological response to primary chemotherapy in patients with locally advanced breast cancer (LABC) grouped according to ER, PR and HER2 status." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 626. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.626.

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626 Background: The determination of ER and PR has a considerable importance when evaluating the prognosis and the response to treatment in breast cancer (BC). Assessment of HER2 status is also a standard for the management of BC. Hormone receptors (HR), HER2, and increasingly, genomic profiles distinguish at least four major classes of BC: HER2+; HER2-HR+, which can be divided into two classes, favorable and unfavorable; and basal-like that express neither HER2 nor HR. In the clinical practice is possible to divided BC according to ER, PR and HER2: ER-PR-HER2+, ER-PR-HER2-, ER+PR+HER2-, ER+RP+HER2+; and less frequently ER+PR-HER2-, ER+PR-HER2+, ER-PR+HER2+ and ER-PR+HER2-. In the neoadjuvant setting the pathological complete response (pCR) to primary chemotherapy (PC) is associated to negativity for ER and PR receptors, and in patients (pts) with HER2 + BC, the addition of trastuzumab to PC increasing the rate of pCR. The aims of this study were to determine the pCR of PC with anthracyclines (A) and taxanes (T) in pts with LABC grouped according to ER, PR and HER2 status. Methods: Pts with LABC treated with PC including A and T were grouped according to ER, PR and HER2 status, and the pCR rate were analyzed using the chi-squared test and correlations with a p value of ≤0,05 were considered statistically significant. Results: A total of 103 pts were treated. There were 14.6% of ER-PR-HER2+ BC, 23.3% ER-PR-HER2-, 35.0%ER+PR+HER2-, 8.7% ER+PR+HER2+, 11.7% ER+PR-HER2-, 2.9% ER+PR-HER2+, 1.9% ER-PR+HER2+, and 1.9% ER-PR+HER2-. For the analysis of pCR only 100 pts were included. There were18 pts who achieved a pCR. Of these pts, 9/18 (50.0%) were RE-RP-HER2-, 5/18 (27.8%) ER-PR-HER2+, 3/18 (16.7%) ER+PR+HER2+, and 1/18 (5.6%) ER+PR+HER2- (p≤0.01). The table 1 show the pCR rate for each subgroup of BC. Conclusions: In patients with LABC to group BC according to ER, PR and HER2 status can help to predict pCR to PC. [Table: see text] No significant financial relationships to disclose.

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Bachier, Carlos R., Paul Shaughnessy, Brad Smith2, Richard Salinas, and Charles F. LeMaistre. "Interleukin-2 and Granulocyte-Macrophage Colony Stimulating Factor Is an Alternative to Donor Lymphocyte Infusion for Relapse after Allogeneic Stem Cell Transplantation and Is Associated with Increase Immune Effector Cells and Polarization to Type 2 Dendritic Cells." Blood 110, no. 11 (November 16, 2007): 1647. http://dx.doi.org/10.1182/blood.v110.11.1647.1647.

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Abstract Donor lymphocyte infusion (DLI) is use for relapse after allogeneic stem cell transplant (ASCT). Immune activation with cytokines maybe an alternative to DLI. We administered Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Interleukin-2 (IL-2) at the time of relapse after ASCT in patients (pts) with hematologic malignancies. Pts. received subcutaneous GM-CSF at 500 mcg/day on days 1–14 and IL-2 at 1 × 106 units/m2/day on days 8–14. Pts. were off immunosuppressive therapy and had no prior history of graft versus host disease (GVHD) at the start of treatment. Twelve pts. received IL-2/GM-CSF for treatment of relapse AML (7), ALL (2), CML (1), MDS (2). Median age was 55 (range 8–66). Stem cell sources included: peripheral blood = 9, bone marrow = 2, umbilical cord blood (UCB) = 1. Donor sources were: match-related sibling = 4 and match-unrelated donor = 8 (UCB=1). Nine pts. had resistant relapse or primary resistant disease at time of ASCT. Median time from transplant to relapse was 4 months (range = 1–14). Two pts. had failed DLI and 5 pts. had received reinduction chemotherapy prior to IL-2/GM-CSF. Eight pts. responded to IL-2/GM-CSF (CR = 7, PR = 1). Two pts. remain disease free at 18 and 26 months post IL-2/ GM-CSF. Six pts. developed GVHD and of these 4 were responders. Two pts. had GM-CSF discontinued due to increase in peripheral blood blasts. No other toxicities related to IL-2/GM-CSF except for mild flu-like symptoms. The table below summarizes quantitative analysis of immune activation. Values represent means +/− standard error at day 0 (first day of GM-CSF), day 8 (prior to start of IL-2) and day 14 (last day of IL-2 and GM-CSF). P-values are based on paired t-test analysis of day 8 versus day 0 and day 14 versus day 0, respectively. Flow cytometric analysis showed an increase in the numbers of T-lymphocytes (CD3) and T-cell subsets (CD3/CD8 and CD3/CD4) as well as an increase in natural killer cells (CD16/56). Although no differences were seen in the number of dendritic cell subsets, DC1/DC2 ratios decreased with the administration of GM-CSF/IL-2. Limited (n= 4) CD4/FoxP3 analysis did not show change in absolute numbers with administration of GM-CSF/IL-2 (data not shown). In conclusion, cytokine therapy with IL-2/GM-CSF is well tolerated and is an alternative to DLI for relapse after ASCT. Flow cytometry analysis demonstrated a quantitative increase in immune effector cells and polarization to DC2. IMMUNE ACTIVATION FLOW CYTOMETRY ASSAYS D0 (Mean +/− SE) D8 (Mean +/− SE) D14 (Mean +/− SE) P-Value (Day7–0) P-Value (Day 14–0) SE=Standard Error; DC = dendritic cells CD3 (K/uL) 309 +/− 117 535 +/− 103 1306 +/− 403 0.034 0.027 CD3/CD8 (K/uL) 94 +/− 42 174 +/− 33 325 +/− 90 0.021 0.029 CD3/CD4 (K/uL) 309 +/− 117 404 +/− 102 977 +/− 310 0.249 0.045 CD16/CD56 (K/uL) 124 +/− 60 404 +/− 110 496 +/− 162 0.029 0.044 CD19 K/uL) 68 +/−39 89 +/− 36 116 +/− 31 0.183 0.044 Total Lymphs (K/uL 488 +/− 167 942 +/− 160 2353 +/− 532 0.016 0.013 CD11(DC1) (K/uL) 97.1 +/− 60.7 46.3 +/− 32.5 32.6 +/− 27.5 0.108 0.101 CD123(DC2) (K/uL) 32.1 +/− 7.3 39.7 +/− 15.9 45.4 +/− 35.8 0.694 0.628 DC1/DC2 2.77 +/− 1.26 0.68 +/− 0.35 0.61 +/− 0.07

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Maioli, Marcos Rogério, and Carlos Alberto Tomelin. "Estratégias competitivas praticadas por empresas de organização de eventos de Curitiba e região metropolitana – PR." Revista de Turismo Contemporâneo 7, no. 2 (December 2, 2019): 240–59. http://dx.doi.org/10.21680/2357-8211.2019v7n2id16975.

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Temas relacionados às estratégias competitivas têm sido cada vez mais abordados por pesquisadores que buscam indicativos do comportamento organizacional realizado por empresas frente a um ambiente mutável. A competição entre as organizações faz com que aquelas que não conseguem se adaptar a mudanças tenham dificuldades em sobreviver no mercado. O objetivo deste estudo foi analisar a influência das estratégias competitivas nas formas de gestão das empresas de eventos da cidade de Curitiba-PR e Região Metropolitana. O estudo é do tipo exploratório-descritivo, com análises quantitativas, e se deu por meio de aplicação de instrumento de coleta de dados junto a gestores de empresas organizadoras de eventos baseado nas estratégias competitivas de Porter, Ansoff e Miles e Snow. A estratégia mais indicada pela média de homogeneidade foi a estratégia de diversificação de Ansoff, e a segunda e terceira foram as estratégias de Miles e Snow de atitudes analíticas e atitudes prospectivas. Como principais resultados aferiu-se que as empresas utilizam estratégias de forma aleatória e não vinculadas a um planejamento estratégico formulado e discutido para obter o maior retorno e uma maior aplicabilidade com possibilidade de retorno na resolução de problemas. Percebe-se que devido à concorrência cada vez mais acirrada as empresas que subsidiam suas decisões em estratégias já consolidadas possuem fatores de sobrevivência em longo prazo. Palavras-chave: Empresas de eventos. Estratégia de competitividade. Gestão de empresas.

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Bleiber, Gabriela, Miguel Munoz, Angela Ciuffi, Pascal Meylan, and Amalio Telenti. "Individual Contributions of Mutant Protease and Reverse Transcriptase to Viral Infectivity, Replication, and Protein Maturation of Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1." Journal of Virology 75, no. 7 (April 1, 2001): 3291–300. http://dx.doi.org/10.1128/jvi.75.7.3291-3300.2001.

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ABSTRACT Human immunodeficiency virus type 1 (HIV-1) variants resistant to protease (PR) and reverse transcriptase (RT) inhibitors may display impaired infectivity and replication capacity. The individual contributions of mutated HIV-1 PR and RT to infectivity, replication, RT activity, and protein maturation (herein referred to as “fitness”) in recombinant viruses were investigated by separately cloning PR, RT, and PR-RT cassettes from drug-resistant mutant viral isolates into the wild-type NL4-3 background. Both mutant PR and RT contributed to measurable deficits in fitness of viral constructs. In peripheral blood mononuclear cells, replication rates (means ± standard deviations) of RT recombinants were 72.5% ± 27.3% and replication rates of PR recombinants were 60.5% ± 33.6% of the rates of NL4-3. PR mutant deficits were enhanced in CEM T cells, with relative replication rates of PR recombinants decreasing to 15.8% ± 23.5% of NL4-3 replication rates. Cloning of the cognate RT improved fitness of some PR mutant clones. For a multidrug-resistant virus transmitted through sexual contact, RT constructs displayed a marked infectivity and replication deficit and diminished packaging of Pol proteins (RT content in virions diminished by 56.3% ± 10.7%, and integrase content diminished by 23.3% ± 18.4%), a novel mechanism for a decreased-fitness phenotype. Despite the identified impairment of recombinant clones, fitness of two of the three drug-resistant isolates was comparable to that of wild-type, susceptible viruses, suggestive of extensive compensation by genomic regions away from PR and RT. Only limited reversion of mutated positions to wild-type amino acids was observed for the native isolates over 100 viral replication cycles in the absence of drug selective pressure. These data underscore the complex relationship between PR and RT adaptive changes and viral evolution in antiretroviral drug-resistant HIV-1.

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Hirao, K., M. Higuchi, and N. Soga. "Upconversion mechanism of Pr 3+ -doped fluoride fiber glass." Journal of Luminescence 60-61 (April 1994): 115–18. http://dx.doi.org/10.1016/0022-2313(94)90108-2.

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Yanbing, Hou, Hua Yulin, and Xu Xurong. "The electroluminescence of Pr ions in ZnS thin films." Journal of Luminescence 60-61 (April 1994): 916–18. http://dx.doi.org/10.1016/0022-2313(94)90311-5.

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Purim, Kátia Sheylla Malta, and Fernanda Cristina Wroblevski. "Exposição e proteção solar dos estudantes de medicina de Curitiba (PR)." Revista Brasileira de Educação Médica 38, no. 4 (December 2014): 477–85. http://dx.doi.org/10.1590/s0100-55022014000400009.

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Trata-se de estudo observacional de corte transversal que teve como objetivo analisar a exposição e proteção solar de estudantes de Medicina de Curitiba (PR), através de questionário autoaplicado, comparando os resultados entre alunos de ambos os sexos que tiveram ou não intervenção da disciplina de Dermatologia. Análise estatística pelo Teste Exato de Fisher e Qui-Quadrado. Amostra composta de 398 estudantes com perfil sociodemográfico caracterizado principalmente por mulheres (54,9%), brancas, predominando a média de 23,8 anos. A maioria cursou a disciplina de Dermatologia (72,1%) e possui conhecimentos básicos sobre fotoproteção (65,3%). Quanto às práticas de exposição solar, os horários preferidos foram após 16 horas (55%) e entre 10-16 horas (23,3%), com uso diário de protetor solar (36,5%) e fator de proteção 30 ou superior (65,5%). Em relação aos riscos individuais para carcinomas cutâneos, 61,2% se enquadraram nos fototipos II e III de Fitzpatrick. Histórico familiar de câncer de pele ocorreu em 24,6% nos avós e/ou pais. Entre as mulheres que cursaram a disciplina de Dermatologia, verificou-se aplicação diária de fotoprotetor mais vezes ao dia e com fator de proteção solar mais alto.

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Rocha, Adilson Carlos da, Gilberto Francisco Ceretta, and Camila Battisti. "ANÁLISE DO COMPORTAMENTO ESTRATÉGICO DAS EMPRESAS LOCALIZADAS NO MUNICÍPIO DE VITORINO – PR." Revista GESTO 4, no. 2 (December 16, 2016): 13. http://dx.doi.org/10.20912/2358-0216/2016.v4i2.1975.

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<p>Este estudo teve como objetivo analisar o comportamento estratégico das empresas localizadas no município de Vitorino – PR. Conforme a tipologia proposta por Miles e Snow (1978) as empresas podem apresentar quatro tipos de comportamento estratégico, sendo eles o prospector, o defensivo, o analítico e o reativo. Com o intuito de responder ao problema de pesquisa, optou-se pela abordagem quantitativa com característica descritiva. A coleta de dados ocorreu uma amostra de 48 empresas em um universo de 119 empresas existentes no município. Como resultado da pesquisa considerando toda a amostra verificou-se que na área empresarial 42,7% das empresas apresentam comportamento estratégico analítico. Na área de engenharia, tanto o comportamento analítico quanto o reativo foram adotados por 27,8% das empresas, já na área administrativa o comportamento prospector foi o predominante, com 33,3% das empresas. Considerando os resultados inerentes aos comportamentos estratégicos apresentados pelas empresas, não considerando a estratificação por ciclos adaptativos e suas respectivas áreas, os dados evidenciam um equilíbrio entre os quatro tipos de comportamento. Este estudo ressalta a importância de as empresas adotarem um comportamento estratégico bem definido, que seja direcionado aos objetivos empresariais, e que possam potencializar a competitividade das empresas em seu nicho mercadológico.</p>

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Petsch, C. "Aspectos da Evolução da Impermeabilização na Bacia do Córrego Mandacaru, Maringá – PR." Revista Geoamazônia 1, no. 2 (June 30, 2014): 42–58. http://dx.doi.org/10.17551/2358-1778/geoamazonia.n2v1p42-58.

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Laine, Marc, Corinne Frere, Richard Toesca, Julie Berbis, Pierre Barnay, Michel Pansieri, Pierre Michelet, et al. "Ticagrelor versus prasugrel in diabetic patients with an acute coronary syndrome." Thrombosis and Haemostasis 111, no. 02 (2014): 273–78. http://dx.doi.org/10.1160/th13-05-0384.

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SummaryOptimal P2Y12 receptor blockade is critical to prevent ischaemic recurrence in patients undergoing percutaneous coronary intervention (PCI). We aimed to compare the level of platelet reactivity (PR) inhibition achieved by prasugrel and ticagrelor loading dose (LD) in diabetic acute coronary syndrome (ACS) patients undergoing PCI. We performed a single-center prospective open-label randomised trial. Patients with diabetes mellitus undergoing PCI for an ACS were randomised to receive prasugrel 60 mg or ticagrelor 180 mg. The primary endpoint of the study was the level of platelet reactivity (PR) assessed between 6 and 18 hours post-LD using the VASP index. We randomised 100 diabetic patients undergoing PCI for an ACS. No difference was observed in baseline characteristics between the two groups. In particular, the rate of patient receiving insulin therapy was identical (25 vs 28.6%; p =0.7). Ticagrelor achieved a significantly lower PR compared to prasugrel loading dose (17.3 ± 14.2 vs 27.7 ± 23.3%; p=0.009). In addition the rate of high on-treatment platelet reactivity, defined by a VASP ≥50%, tend to be lower in the ticagrelor group although the difference did not reach statistical significance (6 vs 16%; p=0.2). The rate of low on treatment PR was identical (60 vs 54%; p=0.8). The present study demonstrates that ticagrelor LD is superior to prasugrel LD to reduce PR in ACS patients with diabetes mellitus. Whether the higher potency of ticagrelor could translate into a clinical benefit should be investigated.

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Millward, M., A. Mita, M. A. Spear, K. C. Federico, G. K. Lloyd, G. Cropp, M. Mita, and P. Mainwaring. "Phase I trial of NPI-2358 (a novel vascular disrupting agent) plus docetaxel." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 3571. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.3571.

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3571 Background: NPI-2358 is a vascular disrupting agent (VDA) that destabilizes tumor vascular endothelial cell architecture resulting in selective collapse of established tumor vasculature. In murine tumor models NPI-2358 produces tumor regression alone and synergistically with agents such as paclitaxel, docetaxel (TXT) and irinotecan, often with decreased toxicity. Methods: The objective was to determine the Recommended Phase 2 Dose (RP2D) of NPI-2358 in combination with TXT. Patients with previously treated advanced NSCLC or other malignancies where TXT use was appropriate were enrolled. Patients received 75 mg/m2 TXT every 21 days. NPI-2358 was administered IV 2 hours after TXT on Day 1, and alone on Day 8. The dose of NPI-2358 was escalated from the single agent biologic effect dose (BED) of 13.5 mg/m2 to the single agent RP2D of 30 mg/m2 using a 3+3 design. PK was assessed on Days 1 and 8. Results: 13 patients were enrolled of whom 10 had NSCLC. At all dose levels adverse events were consistent with those of both agents given alone. Adverse events commonly associated with NPI-2358 were seen, including nausea, vomiting, fatigue, fever, tumor pain and transient blood pressure elevations. One DLT of nausea, vomiting, dehydration and neutropenia occurred at 30mg/m2. PK analysis did not indicate a drug-drug interaction. Of the patients with NSCLC, 8 had measureable disease of which 2 demonstrated a partial response (PR), with 4 others having lesser regressions. The RP2D was thus 30 mg/m2 of NPI-2358 with 75 mg/m2 TXT. Conclusions: The combination of full dose NPI-2358 and TXT is tolerable. Although a limited data set, activity appears favorable relative to the 5–10% response rate reported with TXT alone in this population. Based on these results, efficacy is now being assessed in Phase 2 (the ADVANCE study), a randomized comparison of TXT ± 30 mg/m2 of NPI-2358 in 2nd- line NSCLC. Of note, entry criteria allow patients with squamous cell carcinoma, as VDAs do not appear to result in unfavorable outcomes associated with some other agents in this sub-population. [Table: see text]

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Vieira, Carolina H. S. D., Carina Kozera, and Daniela Biondi. "Preferência visual de paisagens de Parque Municipal do Passaúna, Curitba, PR." Paisagem e Ambiente, no. 24 (December 31, 2007): 421. http://dx.doi.org/10.11606/issn.2359-5361.v0i24p421-430.

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Pearson, A., and W. S. Brocklesby. "Hole burning studies of Pr 3+ -doped fluoride and chalcogenide glasses." Journal of Luminescence 60-61 (April 1994): 208–11. http://dx.doi.org/10.1016/0022-2313(94)90131-7.

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Xie, Bin Qing, Y. M. Cheung, and S. K. Gayen. "Intra-4f 2 two-photon transitions in Pr 3+ : LiYF 4." Journal of Luminescence 60-61 (April 1994): 661–63. http://dx.doi.org/10.1016/0022-2313(94)90244-5.

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Rodrigues, Evandro De Oliveira, Fabiana Pavão Da Silva, Fabíola Dalmolin, Gabrielle Coelho Freitas, and Gentil Ferreira Gonçalves. "PROJETO DE EXTENSÃO SERVIÇO DE ANESTESIOLOGIA ANIMAL NA UNIVERSIDADE FEDERAL DA FRONTEIRA SUL, CAMPUS REALEZA - PR: EVOLUÇÃO DE 2014 A 2017." REVISTA BRASILEIRA DE EXTENSÃO UNIVERSITÁRIA 10, no. 2 (September 9, 2019): 95–99. http://dx.doi.org/10.24317/2358-0399.2019v10i2.8205.

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Resumo: O projeto de extensão Serviço de Anestesiologia Animal é uma ação contínua vinculada às atividades desenvolvidas na Superintendência Unidade Hospitalar Veterinária Universitária da Universidade Federal da Fronteira Sul, Campus Realeza – PR. Entre seus objetivos está o auxílio à realização de procedimentos ambulatoriais e cirúrgicos, proporcionar terapia e controle da dor em diferentes espécies, estimular o envolvimento acadêmico à vivência das técnicas e protocolos anestésicos. Desde a sua criação em 2014, foram realizados mais de 1.160 procedimentos anestésicos divididos em 77,5% procedimentos em caninos, 18,9% em felinos, 1,9% em silvestres, 0,9% em aves e 0,8% em animais de produção. O número de procedimentos anestésicos realizados desde a implantação, bem como o trabalho desempenhado no projeto de anestesiologia animal, evidenciam a necessidade de manutenção e ampliação de projetos similares. Além de proporcionar o crescimento acadêmico e a vivência profissional, o projeto atua efetivamente no bem-estar dos animais e no auxílio à comunidade externa, principalmente a população carente do município e região. Palavras-chave: Anestesia; Bem-estar Animal; Extensão Universitária; Medicina Veterinária Extension project of Animal Anesthesiology Service at the Universidade Federal da Fronteira Sul, campus Realeza PR: evolution from 2014 to 2017 Abstract: The extension Project Animal Anesthesiology Service is an ongoing action linked to the activities developed at the Superintendência Unidade Hospitalar Veterinária Universitária da Universidade Federal da Fronteira Sul, Campus Realeza - PR. Among its objectives is the assistance to the accomplishment of ambulatory and surgical procedures, to provide therapy and control of pain in different species, and to stimulate the academic involvement to the experience of the techniques and anesthetic protocols. Since its creation in 2014, more than 1,160 anesthetic procedures have been performed, divided into 77.5% procedures in canines, 18.9% in felines, 1.9% in wild animals, 0.9% in birds and 0.8% in animals of production. The number of anesthetic procedures performed since the implantation, as well as the work performed in the animal anesthesiology project, evidences the need for maintenance and expansion of similar projects. In addition to providing academic growth and professional experience, the project works effectively on animal welfare and assistance to the outside community, especially the needy population of the municipality and region. Keywords: Anesthesia; Animal welfare; University extension; Veterinary medicine Proyecto de extensión Servicio de Anestesiología Animal en la Universidade Federal da Fronteira Sul, campus Realeza PR: evolución de 2014 a 2017 Resumen: El proyecto de extensión del Servicio de Anestesiología Animal es una acción continua vinculada a las actividades desarrolladas en la Superintendência Unidade Hospitalar Veterinária Universitária da Universidade Federal da Fronteira Sul, Campus Realeza, Paraná, Brasil. Sus objetivos incluyen ayudar a realizar procedimientos ambulatorios y quirúrgicos, proporcionar terapia y control del dolor en diferentes especies, estimular la participación académica en la experiencia de las técnicas y protocolos anestésicos. Desde su inicio en 2014, se han realizado más de 1,160 procedimientos anestésicos, divididos en 77,5% de procedimientos caninos, 18,9% de felinos, 1,9% de animales salvajes, 0,9% de aves de corral y 0,8%. Animales de producción. El número de procedimientos anestésicos realizados desde la implantación, así como el trabajo realizado en el proyecto de anestesiología animal, evidencia la necesidad de mantenimiento y expansión de proyectos similares. Además de proporcionar crecimiento académico y experiencia profesional, el proyecto trabaja efectivamente en el bienestar animal y la asistencia a la comunidad externa, especialmente a la población necesitada del municipio y la región. Palabras-clave: Anestesia; Bienestar animal; Extensión universitaria; Medicina veterinaria

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Rasheed, Asma. "Correlation of HER-2/neu Status with Estrogen (ER) & Progesterone (PR) Receptor in Breast Malignancies." Proceedings of Shaikh Zayed Medical Complex Lahore 34, no. 1 (December 3, 2020): 30–38. http://dx.doi.org/10.47489/p000s341z7391-9mc.

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Introduction: Prognosis and management of breast cancer are influenced by the classic variables such as histologic type and grade, tumor size, lymph node status, status of hormonal receptors- i.e. estrogen receptor (ER) and progesterone receptor (PR) of the tumor, and, more recently, HER-2/neu (Human Epidermal Growth factor Receptor-2) overexpression. Expression levels of the estrogen, progesterone and HER2/neu receptors which characterize clinically distinct breast tumours have been shown to change during disease progression and in response to systemic therapies. The interrelationship of ER, PR, and HER -2 has come to have a crucial role in the management of breast cancer. Aims & Objectives: To determine the ER, PR and HER2/neu status in breast malignancies. Place and duration of study: The study was conducted at Department of Histopathology, Federal Postgraduate Medical Institute, Shaikh Zayed Hospital Lahore, for the period of Six months. Material & Methods: 30 samples of diagnosed breast cancer were included in study. Formalin fixed paraffin embedded wax block were taken for immunohistochemical staining of ER, PR & HER-2/neu. Results: Out of 30 cases, racially 29 were Punjabi and 1 was Pakhtun. There were 23 mastectomy samples and 7 needle core biopsies. Out of 30 cases, 29 were Infiltrating Ductal Carcinoma. Grade I, II, III 13.3%, 66. 7% and 20% respectively and only one case was of Carcinosarcoma (p<0.01). Overall immunoexpression for ER, PR and HER-2/neu were 33.3% (p<0.01), 56.7% (p<0.05) and 73.3% respectively. Triple positive (TP) cases were 23.3% and triple negative (TN) were 10 %. Regarding ER expression in infiltrating ductal carcinoma, 63.3% were ER negative and 33.3% were ER positive and comparison was statistically highly significant (p<0.01) .PR expression in infiltrating ductal carcinoma showed 56.7% PR positive and 40% PR negative which was statistically significant (p<0.05).There is negative correlation of HER-2/neu positive and ER positive and positive correlation of HER-2/neu positive and PR positive cases. Conclusion: There is inverse correlation of HER-2/neu positive and ER positive and positive correlation of HER-2/neu positive and PR positive cases.

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Jacquier, B., C. Linare`s, R. Mahiou, J. L. Adam, E. De´noue, and J. Lucas. "Efficient blue upconversion in Tm 3+ and Pr 3+ doped BIGaZYbTZr glasses." Journal of Luminescence 60-61 (April 1994): 175–78. http://dx.doi.org/10.1016/0022-2313(94)90123-6.

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Anghelov, B. M. "Intermediate coupled wave functions of R3+ in LiRP4O12 (R = Pr or Tm)." Journal of Luminescence 47, no. 1-2 (August 1990): 59–64. http://dx.doi.org/10.1016/0022-2313(90)90059-k.

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Reis, Luiza Naujorks, Cézane Priscila Reuter, Jane Dagmar Pollo Renner, Leandro Tibiriçá Burgos, Silvia Isabel Rech Franke, and Miria Suzana Burgos. "High urate concentration is associated with elevated blood pressure in schoolchildren." Journal of Pediatric Endocrinology and Metabolism 31, no. 11 (November 27, 2018): 1207–12. http://dx.doi.org/10.1515/jpem-2018-0227.

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Abstract Background Studies in adults have shown a relationship between high blood pressure and hyperuricemia, but few studies have investigated this association in children and adolescents. The aim of the present study was to associate urate concentration with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in schoolchildren. Methods This cross-sectional study used a sample of 2335 schoolchildren in basic education between 7 and 17 years old. Blood pressure was classified by percentile according to Brazilian parameters for sex and age, reclassified into two categories: normal and borderline/hypertension. Blood collection to obtain serum for urate concentration analysis was performed after a 12-h fast. Values above 5.5 mg/dL were considered hyperuricemia. Descriptive data were presented in frequency and percentage. Linear regression and Poisson regression (prevalence ratio [PR]) was used to test the association between urate concentration and blood pressure. Results Urate concentration was weakly associated with SBP (β: 0.05; 95% CI: 0.02–0.08) and DBP (β: 0.03; 95% CI: 0.01–0.05) z-scores. Schoolchildren with hyperuricemia had a higher prevalence of high SBP (PR: 1.12; p<0.001) and DBP (PR: 1.08; p<0.001). Conclusions Elevated urate concentration is associated with altered blood pressure in schoolchildren.

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Aganezov, S. S., V. N. Ellinidi, A. V. Morotskaya, A. S. Artemyeva, A. O. Nyuganen, and N. V. Aganezova. "Endometrial expression of leukemia inhibitory factor in women with different estrogen/progesterone receptor status of the endometrium." Obstetrics, Gynecology and Reproduction 13, no. 2 (July 4, 2019): 85–94. http://dx.doi.org/10.17749/2313-7347.2019.13.2.085-094.

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Aim: to analyze the endometrial expression of leukemia inhibitory factor (LIF) related to the estrogen/progesterone receptor endometrial status in women with the history of reproductive dysfunctions.Materials and methods. The main group consisted of patients with the history of infertility (n = 81) or early pregnancy loss (n = 40). The control group included 16 women with normal fertility. At days 6–8 after ovulation, endometrial biopsy was performed and peripheral blood samples were taken to assess the estradiol and progesterone levels. Histological and immunohistochemical (to quantify the estrogen (ER)/progesterone (PR) receptors and LIF expression) examinations of the endometrium biopsy materials were carried out.Results. In the middle phase of the secretion, women of the control group showed higher levels of LIF expression in the endometrial glands (94%; n = 15) and stroma (88 %; n = 14) significantly more often than patients with reproductive dysfunctions – 69 % (n = 84) and 44 % (n = 53) respectively (p < 0.05). There was no difference in the endometrial LIF expression between women with infertility and those with early pregnancy loss. In women with a sizable hormone-receptor 'response', a pronounced expression of LIF in the luminal epithelium (87 %; n = 52 out of 60) and stroma (68 %; n = 47 out of 69) was detected more often (p < 0.01) than that in patients with impaired hormone-receptor interactions (61 %, n = 27 of 44; 29 %, n = 20 of 68). High PR expression in the endometrial glands (H-score > 105) indicates the risk of impaired LIF expression in the luminal epithelium (OR =2.6) and stroma (OR = 2.5). Overexpression of ER (H-score > 155) in the endometrial stroma is associated with the risk of sub-normal LIF expression in the endometrial glands (OR = 2.5) and stroma (OR = 2.8).Conclusion. A meaningful connection has been found between the endometrial estrogen/progesterone receptor status and the expression of LIF. Women with well-pronounced endometrial hormone-receptor interactions show high levels of endometrial LIF expression more often. The stromal ER and glandular PR expression levels are considered to be prognostic factors of reduced endometrial LIF expression in the uterine body mucosa.

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Campos, A. F., C. de Mello Donegá, and O. L. Malta. "Theoretical estimates of vibronic transition rates for Pr+3 in different host lattices." Journal of Luminescence 72-74 (June 1997): 166–67. http://dx.doi.org/10.1016/s0022-2313(96)00183-4.

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Mariotto, G., F. Tietz, E. Zanghellini, and M. Ferrari. "Luminescence of Pr 3+ ions in sodium β-Al 2 O 3 crystals." Journal of Luminescence 60-61 (April 1994): 216–19. http://dx.doi.org/10.1016/0022-2313(94)90133-3.

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Aganezov, S. S., V. N. Ellinidi, A. V. Morotskaya, A. S. Artemyeva, A. O. Nyuganen, and N. V. Aganezova. "Endometrial expression of e-cadherin in relation to estrogen-progesterone receptor characteristics of the endometrium." Obstetrics, Gynecology and Reproduction 14, no. 2 (July 26, 2020): 163–73. http://dx.doi.org/10.17749/2313-7347/ob.gyn.rep.2020.084.

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Aim: to evaluate the endometrial expression of e-cadherin in relation to the estrogen-progesterone-receptor status of the endometrium.Materials and methods. In total 137 women were examined including 81 patients with infertility and 40 with a history of early pregnancy loss (main group); for comparison, 16 healthy fertile women (control group) were also examined. Endometrial aspiration biopsy was performed on 6–8 days after ovulation; in parallel, a peripheral blood sample was taken to determine the levels of estradiol and progesterone. A histological and immunohistochemical study of the endometrium with determination of estrogen (ER) and progesterone (PR) receptors and e-cadherin expression was carried out.Results. All fertile women (n = 16) and only 44 % (n = 53) of patients in the main group had the normal pattern of hormonereceptor endometrial interactions, i. e., low expression of ER and PR in the endometrial glands as well as reduced expression of ER and high expression of PR in the endometrial stroma. The endometrial e-cadherin expression was assessed in the following cohorts: a) women with normal hormone-receptor interactions (16 women in the control group and 53 women in the main group); b) with abnormal variants of hormone-receptor interactions in the endometrium (68 patients in the main group). The frequency of reduced e-cadherin expression was significantly lower in the cohort of women with normal estrogenprogesterone-receptor endometrial status (a) than in the cohort of women with abnormal variants of the endometrial “response” (b): in the luminal epithelium – in 5 % (3 out of 63) (а) vs. 17 % (8 out of 47) (b) (p < 0.05); in the glands – in 13 % (9 out of 69) (a) vs. 37 % (25 out of 68) (b) (p < 0.05).Conclusion. The estrogen-progesterone-receptor status of the endometrium is significant for the e-cadherin expression in the luminal epithelium and glands of the endometrium.

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Sonpavde, Guru, Gregory Russell Pond, Arnoud J. Templeton, Daniel Peter Petrylak, Bertrand F. Tombal, Mark Rosenthal, and Ian Tannock. "Association of changes in measurable disease by RECIST with survival in metastatic castration-resistant prostate cancer (mCRPC)." Journal of Clinical Oncology 33, no. 7_suppl (March 1, 2015): 186. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.186.

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186 Background: In men with mCRPC receiving chemotherapy, measurable disease response by World Health Organization criteria has been demonstrated to be prognostic for overall survival (OS). We aimed to explore the association of changes in measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) with OS. Methods: Data from the control arm (n=612) of the phase III VENICE trial receiving docetaxel plus prednisone combined with placebo were available. Data on baseline clinical and laboratory variables were obtained in addition to outcome measures: best RECIST 1.0 response, PSA response and OS. Cox proportional hazards regression was used to evaluate the prognostic ability of RECIST-defined changes for OS using a 90-day landmark analysis. Results: 363 of 612 patients (59.3%) had measurable lesions, of whom 296 were evaluable for landmark analysis. 28 (9.5%) had progressive disease (PD) prior to day 90, while 58 (19.6%) had unconfirmed partial response (PR), i.e. declines ≥30% of the sum of diameters of target lesions. Median OS beyond day 90 for men with PR, stable disease (SD), and PD was 28.3, 23.3, 11.4 months, respectively (P < 0.001). In a multivariable analysis adjusting for pain, PCWG-2 subtype, type of progression (PSA vs. other), Gleason Score (≤ 7 vs. > 7), PSA, derived neutrophil-lymphocyte ratio, ECOG performance status and alkaline phosphatase, the hazard ratio (HR) for OS for patients with PR was 0.64 (95% CI 0.42 – 0.99, P = 0.045) compared to those without PR, and 1.78 (95% CI 1.07 – 2.95, P = 0.026) for those with PD compared to those without PD. PD remained significant (HR = 1.85, 95% CI 1.10 – 3.12, P = 0.020) after adjusting for PSA changes, but PR (P = 0.14) did not. Conclusions: In men with mCRPC receiving first-line docetaxel-based chemotherapy PR and PD by RECIST 1.0 within 90 days were associated with longer or shorter OS, respectively. Given the more frequent detection of measurable disease with current imaging, the accrual of patients with measurable tumors in phase II trials to assess RECIST changes may provide an objective signal of efficacy of new drugs.

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Schoab, Viviane Aparecida, Diego Araujo Lazanha, Ronaldo Ferreira Maganhotto, and Diogo Lüders Fernandes. "O compartilhamento das experiências vivenciadas na RPPN Ninho do Corvo, Prudentópolis/PR, no TripAdvisor e sua classificação nas esferas da Economia da Experiência." Revista de Turismo Contemporâneo 8, no. 1 (April 30, 2020): 127–48. http://dx.doi.org/10.21680/2357-8211.2020v8n1id15797.

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O turismo de aventura é um segmento da atividade turística que oferece aos consumidores produtos experienciais que tem a capacidade de estimular diversas das dimensões da esfera da economia da experiência. Muitas destas são relatadas nas redes e mídias sociais pelos usuários e influenciam a compra por produtos e serviços turísticos neste segmento. A RPPN do Ninho do Corvo, localizada no Município de Prudentópolis, é um destes empreendimentos que possuem relato dos visitantes quanto as atividades de esportes radicais oferecidos pelo estabelecimento. Portanto, o objetivo deste estudo é identificar com base nos relatos dos usuários do Tripadvisor, quais as dimensões da esfera da economia da experiência são estimuladas pelas atividades na RPPN Ninho do Corvo em Prudentópolis. A pesquisa em questão se caracteriza por ser de natureza qualitativa, exploratória e descritiva e se utilizou da netnografia como técnica de coleta de dados e do programa de análise qualitativa MAXQA para auxiliar na apresentação e análise dos dados. Foi constato por meio do estudo que os relatos no site se referem principalmente as dimensões das experiencias de evasão, entretenimento e contemplação, vividas pelos visitantes na RPPN Ninho do Corvo. Palavras-chave: Experiência. Rede Social. TripAdvisor. Turismo de Aventura. Prudentópolis.

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Hilton, Heidi N., Tram B. Doan, J. Dinny Graham, Samantha R. Oakes, Audrey Silvestri, Nicole Santucci, Silke Kantimm, et al. "Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease." Oncotarget 5, no. 18 (August 16, 2014): 8651–64. http://dx.doi.org/10.18632/oncotarget.2354.

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Bertolo, Angélica Patrícia, Daiane Lançanova, Eloiza Muzzolon, Amábile Trento, Eduarda Molardi Bainy, and Cátia Tavares dos Passos. "EXPERIÊNCIA DO USO DAS BOAS PRÁTICAS DE FABRICAÇÃO PARA MELHORIA DAS CONDIÇÕES HIGIÊNICO-SANITÁRIAS DA FEIRA DO AGRICULTOR DE LARANJEIRAS DO SUL – PR." REVISTA BRASILEIRA DE EXTENSÃO UNIVERSITÁRIA 7, no. 1 (July 27, 2016): 51–57. http://dx.doi.org/10.36661/2358-0399.2016v7i1.3101.

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Esse trabalho teve como objetivo melhorar as condições higiênico-sanitárias dos alimentos comercializados na Feira do Produtor do município de Laranjeiras do Sul-PR para garantir a qualidade dos alimentos e a saúde dos consumidores. Para isso, foi inicialmente realizada uma pesquisa exploratória das condições higiênico-sanitárias dos ambientes de preparo, manipulação e comercialização dos alimentos a partir de visitas técnicas e diagnósticos das condições das propriedades dos agricultores e da comercialização de alimentos na feira. As não conformidades identificadas durante essa etapa do trabalho foram utilizadas para elaborar o curso de BPF baseado na legislação federal vigente focado, porém, na realidade dos feirantes. Os cursos foram ministrados em três locais para grupos de agricultores e participantes da feira, totalizando 101 pessoas. Após a execução dos treinamentos, foi realizado o monitoramento das atividades para observar o atendimento às boas práticas na feira e os resultados foram analisados de forma qualitativa e interpretativa. Como resultado, conclui-se que os cursos foram eficazes, pois melhorias significativas foram constatadas no local do estudo, como a melhoria dos hábitos de higiene praticados pelos feirantes, como práticas adequadas no preparo e comercialização de alimentos.

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Andretta, Marcela Heloisa, Evandra Gusatti, Pricila Da Silveira, Amábile Trento, Leide Graciela Blanco Mattje, and Eduarda Molardi Bainy. "DESENVOLVIMENTO DE FERRAMENTA DE CÁLCULO DA INFORMAÇÃO NUTRICIONAL PARA ROTULAGEM DE PRODUTOS ALIMENTÍCIOS COMERCIALIZADOS NA FEIRA DO AGRICULTOR DE LARANJEIRAS DO SUL-PR." REVISTA BRASILEIRA DE EXTENSÃO UNIVERSITÁRIA 7, no. 2 (August 23, 2016): 67–73. http://dx.doi.org/10.36661/2358-0399.2016v7i2.3104.

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A Feira do Agricultor fornece uma importante fonte de renda para a agricultura familiar do município de Laranjeiras do Sul, na qual são comercializados principalmente hortaliças, produtos de panificação, massas alimentícias, doces e derivados do leite. O presente projeto de extensão universitária teve como objetivo a elaboração de uma ferramenta de cálculo de informação nutricional de produtos alimentícios. A partir de uma pesquisa exploratória, foi verificado que poucos produtores possuíam produtos alimentícios com rótulos e os mesmos tinham interesse na obtenção dos rótulos para se adequarem às normas municipal e federal. Para isso, uma ferramenta de cálculo foi desenvolvida em planilha eletrônica baseada na metodologia proposta pela Agência Nacional de Vigilância Sanitária (ANVISA) e em tabelas de composição de alimentos (TACO). Os feirantes foram conscientizados da importância de obter produtos alimentícios portando rótulos, e um levantamento da situação atual da feira foi realizado. Com o processo de rotulagem dos alimentos, as receitas tiveram que ser padronizadas, e o rendimento da produção foi medido. O serviço de confecção dos rótulos foi oferecido para os produtores que comercializavam os seus alimentos na feira e depois estendido para a comunidade. Palavras-chave: Composição dos Alimentos, Rótulos, Feiras Livres, Extensão Universitária. Development of a nutritional information calculation tool for labeling the food products sold at the Farmer’s Market from Laranjeiras do Sul-PR Abstract: The Farmer’s Market provides an important income source for family farming in the city of Laranjeiras do Sul,he where vegetables, bakery products, pasta, sweets and milk-based foods are the main products for sale. This university extension project was aimed at developing a nutritional information calculation tool for the food products. From an exploratory study, it was found that only a few producers had food products with labels and they were interested in getting the labels to suit the municipal and federal standards. For this, a calculation tool was developed with electronic spreadsheets based on the methodology proposed by the Agência Nacional de Vigilância Sanitária (National Health Surveillance Agency - ANVISA) and food composition tables (TACO). The food sellers were made aware about the importance of obtaining products with labels and a survey of the current Farmer’s market situation was conducted. With the process of food labeling, the recipes were standardized and production yield was measured. The labeling service was offered to the Farmer’s Market producers and then offered to the community. Key-words: Food composition, Labels, Farmer’s Market, University Extension. Desarrollo de herramienta de cálculo de información nutricional para el etiquetado de los productos alimenticios comercializados en la feria de agricultores de Laranjeiras do Sul-PR/Brasil Resumen: La Feria de Agricultores proporciona una fuente de renta importante para la agricultura familiar en la ciudad de Laranjeiras do Sul, ubicada al sur de Brasil, donde son comercializados las verduras, productos de panadería, pastas, dulces y alimentos a base de leche. Este proyecto de extensión universitaria tuvo como objetivo el desarrollo de una herramienta de cálculo de la información nutricional de los productos alimenticios. A partir de un estudio exploratorio, se verificó que solo unos pocos productores tenían productos alimenticios con etiquetas pero estaban interesados en conseguir-las para adaptarse a las normas municipales y federales. Para ello, una herramienta de cálculo fue desarrollada con hojas de cálculo electrónicas basadas en la metodología propuesta por la Agencia Nacional de Vigilancia Sanitaria (ANVISA) y las tablas de composición de alimentos (TACO). Los vendedores de alimentos se hicieron conscientes de la importancia de la obtención de productos con etiquetas y una encuesta de la situación corriente de la Feria de Agricultores se llevó a cabo. Con el proceso de etiquetado de los alimentos, las recetas fueron estandarizadas y se midió el rendimiento de producción. El servicio de etiquetado se ofreció a los productores de la Feria de Agricultores y luego se ofreció también a la comunidad. Palabras-clave: Composición de los Alimentos, Etiquetas, Mercado de los Agricultores, Extensión Universitaria.

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Guo, Jun, Lu Si, Yan Kong, Keith T. Flaherty, Xiaowei Xu, Yanyan Zhu, Christopher L. Corless, et al. "Phase II, Open-Label, Single-Arm Trial of Imatinib Mesylate in Patients With Metastatic Melanoma Harboring c-Kit Mutation or Amplification." Journal of Clinical Oncology 29, no. 21 (July 20, 2011): 2904–9. http://dx.doi.org/10.1200/jco.2010.33.9275.

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Purpose Melanomas harbor aberrations in the c-Kit gene. We tested the efficiency of the tyrosine kinase inhibitor imatinib in selected patients with metastatic melanoma harboring c-Kit mutations or amplifications. Patients and Methods Forty-three patients with metastatic melanoma harboring c-Kit aberrations were enrolled on this phase II trial. Each patient received a continuous dose of imatinib 400 mg/d unless intolerable toxicities or disease progression occurred. Fifteen patients who experienced progression of disease were allowed to escalate the dose to 800 mg/d. Results Forty-three patients were eligible for evaluation, and the median follow-up time was 12.0 months. The median progression-free survival (PFS) was 3.5 months, and the 6-month PFS rate was 36.6%. Rate of total disease control was 53.5%: 10 patients (23.3%; 95% CI, 10.2% to 36.4%) and 13 patients (30.2%; 95% CI, 16.0% to 44.4%) achieved partial response (PR) and stable disease (SD), respectively. Eighteen patients (41.9%) demonstrated regression of tumor mass. Notably, nine of the 10 PRs were observed in patients with mutations in exons 11 or 13. The 1-year overall survival (OS) rate was 51.0%. The median PFS and OS times for patients who had PR or SD versus disease progression were 9.0 months versus 1.5 months (P < .001) and 15.0 months versus 9.0 months (P = .036), respectively. Imatinib 400 mg/d was well tolerated, and only one of the 15 patients who received dose escalation to 800 mg/d achieved SD. Conclusion Imatinib demonstrated significant activity in patients with metastatic melanoma harboring genetic c-Kit aberrations, with an overall response rate of 23.3%. Escalation to 800 mg/d could not restore disease control.

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Schacht, G. L. "A Presença de Formações Relictuais de Vegetação em Apucarana (PR); A Formação de Araucária (Araucaria angustifolia)." Revista Geoamazônia 2, no. 4 (December 31, 2014): 108–21. http://dx.doi.org/10.17551/2358-1778/geoamazonia.v2n4p108-121.

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Malinowski, M., M. F. Joubert, and B. Jacquier. "Infrared to blue up-conversion in Pr 3+ doped YAG and LiYF 4 crystals." Journal of Luminescence 60-61 (April 1994): 179–82. http://dx.doi.org/10.1016/0022-2313(94)90124-4.

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Ganem, Joseph, W. M. Dennis, and W. M. Yen. "One-color sequential pumping of the 4f5d bands in Pr-doped yttrium aluminum garnet." Journal of Luminescence 54, no. 2 (September 1992): 79–87. http://dx.doi.org/10.1016/0022-2313(92)90250-d.

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Dos Santos, Mariana Barcelos Fabrício, Isabela Mascarenhas De Oliveira, Mateus Dias Antunes, Sonia Maria Marques Gomes Bertolini, Fernanda Shizue Nishida, and Siméia Gaspar Palácio. "Efeitos do Método Pilates no equilíbrio, na força muscular e flexibilidade em idosas." PAJAR - Pan American Journal of Aging Research 8, no. 1 (July 31, 2020): e34953. http://dx.doi.org/10.15448/2357-9641.2020.1.34953.

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Objetivos: analisar os efeitos do Método Pilates no equilíbrio, na força muscular e na flexibilidade em mulheres idosas. Método: estudo de natureza intervencional com idosas do município de Maringá/ PR. Foram avaliadas em relação ao equilíbrio, à flexibilidade e à força muscular. Ao término da avaliação, iniciaram os atendimentos fisioterapêuticos que consistiram em 10 sessões, realizadas em grupo, com duração de 60 minutos, utilizando o Método Pilates no solo. A análise estatística foi realizada pelo teste Kolmogorov-Smirnov, seguida do teste t/Wilcoxon, e do teste t/Mann – Whitney, adotando 5% como índice de significância. Resultados: obteve-se melhora de todas as variáveis, sendo: 10,71%, para a flexibilidade; 25,47%, para o equilíbrio; 46,05%, para a força dos músculos abdominais; e 65,44%, para os músculos extensores de tronco. Conclusões: o Método Pilates no solo mostrou-se eficaz na melhora de todas as variáveis estudadas em mulheres idosas.

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Gomes, Henrique, and Hellen Monique Silva Bet. "ASSOCIAÇÃO ENTRE O CRONOTIPO E O DESEMPENHO ESCOLAR DE ALUNOS DO ENSINO FUNDAMENTAL DE DUAS ESCOLAS PÚBLICAS DE CURITIBA, PR." Revista Temas em Educação 30, no. 2 (June 12, 2021): 152–66. http://dx.doi.org/10.22478/ufpb.2359-7003.2021v30n2.56306.

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O cronotipo constitui fator importante para o aprendizado e tarefas cotidianas. Alterações no ciclo sono-vigília podem ocorrer com maior frequência em adolescentes, o que também pode levar à diminuição de seu desempenho. Atualmente, tem se mostrado que quando o estudante está matriculado no mesmo período de acordo com seu cronotipo, seu desempenho escolar é melhor. Este trabalho teve como objetivo avaliar o cronotipo dos alunos do 9º ano e associar com as notas obtidas ao longo de um semestre. A pesquisa envolveu alunos de dois colégios públicos de Curitiba. As informações foram coletadas através de questionário de identificação do cronotipo. Teve também o apoio de um levantamento documental sobre o desempenho acadêmico dos alunos investigados. Observou-se nos resultados obtidos que o cronotipo intermediário é o mais comum entre esses adolescentes e que apenas 7% deles estudam em horário inapropriado ao seu cronotipo. Ficou demonstrado, também, que o rendimento escolar não sofreu interferência significativa do cronotipo, sexo ou idade do aluno, o que pode estar associado ao pequeno universo amostral de estudantes. Com base nos resultados, conclui-se que a aprendizagem destes estudantes não demonstrou relação com seu tipo cronobiológico, ou com a idade e o sexo, ainda que outras pesquisas sejam necessárias para melhor compreensão dessa relação.

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Furlan, Cássia Cristina, and Bruna Fernanda da Silva. "Infância, gênero e o brincar em um projeto de educação social." EDUCA - Revista Multidisciplinar em Educação 7, no. 17 (September 6, 2020): 880. http://dx.doi.org/10.26568/2359-2087.2020.4725.

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Este artigo tem por objetivo analisar as questões relativas às desigualdades entre meninos e meninas nas relações desenvolvidas no brincar das crianças participantes de um projeto de Educação Social desenvolvido no Vale do Ivaí-PR. É uma pesquisa de cunho qualitativo que utiliza técnicas etnográficas. Na pesquisa, realizamos observações participantes e análise dos relatórios produzidos por educadores/as atuantes no projeto, após as intervenções e entrevistas semiestruturadas com as crianças e os/as educadores/as. A análise de dados baseou-se no método de análise de conteúdo de Bardin (1997). Apontamos que ainda há diferenças de gênero no brincar de meninas e meninos participantes do projeto, as quais ocorrem de maneiras sutis, ficando mais evidentes em práticas binárias já enraizadas na cultura dominante, como em jogos/esportes tradicionais. No decorrer da pesquisa, observamos que as crianças ainda reproduzem muitos aspectos normativos, no entanto também conseguem ressignificar algumas normas de gênero, muitas vezes sem se darem conta.

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Otto, F. W., M. Lukac, and E. L. Hahn. "Spin Hamiltonian spectroscopy and spin-spin cross relaxation by optical pumping of Pr+3: LaF3." Journal of Luminescence 35, no. 6 (September 1986): 321–27. http://dx.doi.org/10.1016/0022-2313(86)90018-9.

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P. Neves, Cleiton. "Diagnóstico Preliminar do Risco Ambiental Associado ao Transporte Rodoviário Internacional de Produtos Perigosos em Foz do Iguaçu-PR." Revista FLAMMAE 2, no. 3 (April 2016): 254. http://dx.doi.org/10.21628/2359-4837/flammae.v2n3p254-257.

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de Mello Donega´, C., M. J. D. Crombag, A. Meijerink, and G. Blasse. "Vibronic transitions in the luminescence spectra of Pr 3+ in Na 5 La(MoO 4 ) 4." Journal of Luminescence 60-61 (April 1994): 74–77. http://dx.doi.org/10.1016/0022-2313(94)90097-3.

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Luditk, Willian Aparecido de Jesus, Priscila Caroza Frasson Costa, and Simone Luccas. "O ENSINO DE MATEMÁTICA COM A UTILIZAÇÃO DE RECURSOS TECNOLÓGICOS: uma sequência de atividades para o ensino de função do 1º grau com a utilização do software Scratch." Ensino da Matemática em Debate 7, no. 2 (August 31, 2020): 225–41. http://dx.doi.org/10.23925/2358-4122.2020v7i2p225-241.

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O presente artigo objetiva compreender as possíveis contribuições da resolução de problemas referente ao conceito de função do 1º grau com a utilização do software Scratch. Para tal, desenvolveu-se algumas atividades com estudantes do 2º ano de Licenciatura em Matemática da Universidade Estadual do Norte do Paraná (UENP) – Campus Cornélio Procópio-PR. A partir destas atividades e das respostas ao questionário entregue ao final, tornou-se possível tecer algumas considerações: evidenciou-se que a utilização do Scratch proporciona o ensino de forma lúdica, construindo diálogos, de modo a responder a situação-problema proposta. Outro fator a se destacar é que o Software pode atuar como instrumento motivador para o ensino de conceitos matemáticos, que vão desde as quatro operações básicas até o trabalho com funções.

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Da Silva, Eduardo T., and Douglas E. C. Martins. "Perfil dos produtores de produtos hidropônicos do município de Colombo - região metropolitana de Curitiba - PR." Revista Acadêmica: Ciência Animal 2, no. 1 (January 15, 2004): 49. http://dx.doi.org/10.7213/cienciaanimal.v2i1.15026.

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Foram realizadas entrevistas com produtores de alface em cultivo hidropônico, em Colombo, região metropolitana de Curitiba com objetivo de verificar a situação atual, bem como identificar os pontos de estrangulamento no sistema de produção. Foram identificados 17 produtores na região, a quem foram realizadas várias visitas para coleta de dados no período de novembro de 2002 a março de 2003. Foi elaborado um questionário, onde foram registradas informações sobre a data de implantação (pico máximo em 1998 com 4 produtores); tamanho da área de produção (23,53% com áreas entre 0,5 e 1,0 ha); idade dos produtores (35,30% com idade entre 20 a 30 anos); grau de instrução (41,19% possuem 1o grau); experiência profissional fora da atividade agrícola (53,0% dos produtores hidropônicos não possuem); origem dos produtores (65% são de origem rural e 35% urbana); de quem foi a iniciativa; a origem do capital para investimento (65% capital próprio); diversidade de produtos produzidos (47,06% apenas 1 variedade); nível de processamento (70,59% apenas embalam); locais de comercialização (pequenos mercados 35,30%); gerenciamento e administração (88,24% o proprietário); marketing (5,89% apenas 1 investe) e ampliação da área (64,71% ampliaram). A pesquisa evidenciou que embora a maioria dos produtores seja proprietário da terra e tenha acesso à tecnologia, sua utilização é feita empiricamente; os produtores estão sem assistência técnica e produzindo por meio de tentativas, demandando uma atuação mais efetiva de órgãos de ensino, pesquisa e extensão da região.

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Yang, Deok-Hwan, Je-Jung Lee, Jung-Joon Min, Se-Ryeon Lee, Yeo-Kyeoung Kim, Hee-Seung Bom, and Hyeoung-Joon Kim. "Clinical Usefulness and Therapeutic Plan with Interim PET/CT Analysis in Malignant Lymphoma." Blood 108, no. 11 (November 1, 2006): 2403. http://dx.doi.org/10.1182/blood.v108.11.2403.2403.

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Abstract FDG-PET, a functional imaging modality used for staging and monitoring response to treatment of malignant lymphoma, has a higher sensitivity and specificity than conventional imaging. PET/CT may be more accurate than conventional imaging in assessing treatment effects to correctly identify patients with residual disease and predict therapy outcomes. We prospectively investigated that PET/CT may provide additional prognostic information in mid-response assessment prior to completion of chemotherapy. Patients and Method: Eighty-six newly diagnosed patients with malignant lymphoma were enrolled from Aug. 2004 to July 2006. Both CT and PET/CT analysis were performed at the time of diagnosis and after the 3rd or 4th chemotherapy. The clinical stage of the patients was assessed according to International Workshop Criteria (IWC). PET/CT imaging was analyzed according to the combination of morphology using the CT portion and by the uptake and location of the FDG-PET portion. The cut off value of the positive in PET/CT was more than max SUV 3.0. We divided them into four different response groups using IWC and PET/CT (CRu-negative, Cru-positive, PR-negative, PR-positive). The limited-stage patients were treated with chemotherapy and involved field radiation therapy and the advanced-stage patients were treated with eight cycles of chemotherapy. However, advanced-stage patients who were older than sixty, if they had CRu-negative in interim analysis, were treated with only six cycles. Results: Median age was 53.5 years (range: 19 – 85). Seventy five patients had Non-Hodgkin’s lymphoma [Indolent-11 (12.8%), Aggressive-64 (74.4%)] and eleven patients (12.8%) had Hodgkin’s lymphoma. Forty-two patients (48.8%) achieved CRu-negative, 6 patients (7.0%) achieved CRu-positive, 20 patients (23.3%) achieved PR-negative and 18 patients (20.9%) showed PR-positive by interim IWC and PET/CT. The relapse rate is significantly different between PET-positive (58.3%) and PET-negative (8.1%) (P=0.000), especially when 12 of 18 patients in PR-positive group (66.7%) relapsed after or during chemotherapy. Figures showed the Kaplan-Meier estimates of overall and progression free survival of 86 patients depending on the combined evaluation of interim IWC and PET/CT. Conclusion: Interim PET/CT analysis was a significantly predictive value of disease progression and survival. The patients with PR-positive according to interim IWC and PET/CT analysis should be considered for an intensive therapeutic plan. Figure Figure

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Zanca, Cássia Rejane Balvedi, and Cineiva Campoli Paulino Tono. "Hábitos dos adolescentes quanto ao uso das mídias digitais." EDUCA - Revista Multidisciplinar em Educação 5, no. 11 (September 4, 2018): 98. http://dx.doi.org/10.26568/2359-2087.2018.2647.

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Esta pesquisa busca apresentar e analisar as mudanças comportamentais das últimas décadas, a partir da influência das tecnologias digitais, observando-se os aspectos positivos e negativos da questão e, consequentemente, o que isso tem provocado na sociedade, e na família, e quais seriam as soluções apresentadas quanto ao uso excessivo e/ou indiscriminado das mídias digitais, seus impactos nos hábitos de vida dos adolescentes, assim como a implicação nos estudos, os transtornos que têm causado à saúde, entre outros. A metodologia adotada é descritiva, bibliográfica, com enfoque qualitativo, complementada por dados quantitativos. A coleta de dados se deu em 4 colégios estaduais de Francisco Beltrão-PR, sendo 2 colégios abaixo da média e 2 acima da média proposta pelo IDEB, sendo este um critério que foi usado apenas para selecionar as escolas pesquisadas. O público estudado consistiu em 336 adolescentes e 17 professores. O prognóstico evidencia motivo de preocupação e necessidade emergente de conscientização da sociedade quanto aos impactos biopsicossociais de uso das tecnologias digitais. Aponta-se, com isso, a necessidade emergente de mudanças na prática pedagógica, nos métodos de ensino e muito mais na gestão escolar dos recursos disponíveis, sobretudo os tecnológicos.

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Kurgacheva, K. D. "Black PR as a Function of the Political Internet (Case Study of Russian Election Campaigns)." Vestnik Povolzhskogo instituta upravleniya 20, no. 1 (2020): 97–102. http://dx.doi.org/10.22394/1682-2358-2020-1-97-102.

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Kamilova, D. P., M. M. Ovchinnikova, E. Sh Ablyaeva, M. M. Leviashvili, N. S. Stuleva, E. V. Broitman, M. A. Ganikhina, et al. "An observational study «FOLLITROPIN» comparing the efficacy of follitropin alpha biosimilar: the real-world data." Obstetrics, Gynecology and Reproduction 15, no. 1 (March 6, 2021): 5–21. http://dx.doi.org/10.17749/2313-7347/ob.gyn.rep.2021.212.

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Introduction. The efficacy and safety of biosimilar follitropin alpha have been demonstrated in randomized blinded prospective clinical trials of phases I and III. Unfortunately, there is a gap between the clinical trials and real clinical practice data. The real-world patient data helps to create an evidence-based background for successful implementation of medicine at everyday practice in a nonselected population.Aim: to investigate the efficacy of follitropin alpha biosimilar therapy (Primapur®) in nonselected real-world population.Materials and Methods. A retrospective observational anonymized cohort study of follitropin alpha biosimilar (Primapur®) as a pre-filled pen injector with a dose adjustment of 5 IU, aimed to investigate its efficacy and safety in a nonselected population with indications to assisted reproductive technologies (ART) was carried out. The ovarian stimulation (OS) protocols included: monotherapy protocols with using only Primapur®; mixed protocols (recombinant and urinary-derived gonadotropins); short protocols with using antagonists of gonadotropin-releasing hormone (GnRH) and long protocols with GnRH agonists. The stimulation protocols were analyzed with Primapur® application for at least 5 days.Results. The overall clinical efficacy of ovarian stimulation cycles (N = 5484) was: oocytes retrieved - 9.5 ± 7.2, mature (MII) - 6.8 ± 6.6, fertilized (2PN) - 6.1 ± 5.8, clinical pregnancy per ET (PR) - 38.4 %. Mixed gonadotropin protocols (N = 2625) vs. monotherapy with Primapur® (N = 2859): oocytes retrieved - 8.6 ± 6.8 vs. 10.3 ± 7.4 (p < 0.001), mature (MII) - 6.7 ± 6.2 vs. 7.7 ± 6.9 (p < 0.001), fertilized (2PN) - 5.8 ± 5.2 vs. 7.2 ± 6.2 (p < 0.001). There were statistically significant differences between oocyte yields in mixed vs. monotherapy protocols due to subgroup differences, including age, body mass index (BMI) and IVF/ICSI attempts. No statistically significant differences were found for PR: 39.3 % vs. 37.6 % (p = 0.314). Monotherapy protocols with GnRH antagonist OS (N = 2183) vs. GnRH agonist (N = 676) revealed: oocytes retrieved - 10.5 ± 7.5 vs. 9.6 ± 7.0 (p = 0.032), mature (MII) - 7.6 ± 6.9 vs. 6.7 ± 5.7 (p < 0.001), fertilized (2PN) - 7.3 ± 6.3 vs. 5.7 ± 5.0 (p < 0.001). There were statistically significant differences between BMI and IVF/ICSI attempts. No statistically significant differences were found for PR: 37.9 % vs. 35.9 % (p = 0.482). All medicines were well tolerated and no serious adverse reactions were reported.Conclusion. This was the largest retrospective observational study conducted in the field of fertility in Russia and involved 5484 ovarian stimulation protocols at 35 IVF clinics. The obtained results demonstrated similar clinical efficacy for follitropin alpha biosimilar Primapur® in different OS protocols in real clinical practice.

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Journal articles on the topic 'PR 2353'

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