Relevant bibliographies by topics / PRDX6

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  2. Dissertations / Theses
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  5. Conference papers

Academic literature on the topic 'PRDX6'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "PRDX6"

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Lee, Young Jae. "Knockout Mouse Models for Peroxiredoxins." Antioxidants 9, no. 2 (2020): 182. http://dx.doi.org/10.3390/antiox9020182.

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Peroxiredoxins (PRDXs) are members of a highly conserved peroxidase family and maintain intracellular reactive oxygen species (ROS) homeostasis. The family members are expressed in most organisms and involved in various biological processes, such as cellular protection against ROS, inflammation, carcinogenesis, atherosclerosis, heart diseases, and metabolism. In mammals, six PRDX members have been identified and are subdivided into three subfamilies: typical 2-Cys (PRDX1, PRDX2, PRDX3, and PRDX4), atypical 2-Cys (PRDX5), and 1-Cys (PRDX6) subfamilies. Knockout mouse models of PRDXs have been d
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Lambros, Lauren, Vien Sturm, and Calli A. Davison-Versagli. "Abstract 6223: Evaluating peroxiredoxins 1-6 and their potential as prognostic biomarkers for uterine corpus endometrial carcinoma." Cancer Research 83, no. 7_Supplement (2023): 6223. http://dx.doi.org/10.1158/1538-7445.am2023-6223.

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Abstract Introduction: Uterine corpus endometrial carcinoma (UCEC) is one of the most commonly diagnosed cancers in women in the United States, where the death rate continues to climb by 1.9% every year due to poor prognostic and therapeutic methodologies. Recently, altered expression patterns of peroxiredoxins (PRDX) (1-6), a family of antioxidant enzymes comprised of six known isoforms, has been connected to overall outcome in many cancers. While recent studies have begun to unravel the potential of PRDXs as prognostic biomarkers in other cancers, PRDX expression patterns and their use as pr
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Xu, Rui, Jiadong Pan, Jie Mei, and Qinglin Zhang. "Systematic Characterization of Prognostic Values of Peroxiredoxin Family in Gastric Cancer." BioMed Research International 2020 (January 9, 2020): 1–9. http://dx.doi.org/10.1155/2020/3948183.

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The peroxiredoxin (PRDX) gene family has been reported to participate in regulating occurrence and development of cancerous diseases, but its exact prognostic values in gastric cancer (GC) remain largely elusive. In the current research, we evaluated the prognostic value in predicting overall survival (OS) of each individual PRDX mRNA expression based on patients’ cohorts from the Kaplan–Meier (KM) plotter database, which contains clinical information and gene expression data obtained from a total of 876 GC patients. Our results revealed that mRNA expressions of PRDX1, PRDX2, PRDX3, and PRDX4
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Quitmeyer, Braden, and Shelley A. Phelan. "Abstract 604: Punicic acid from pomegranate seed oil induces cytotoxicity and oxidative stress in MCF-7 breast cancer cells." Cancer Research 85, no. 8_Supplement_1 (2025): 604. https://doi.org/10.1158/1538-7445.am2025-604.

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Abstract Punicic Acid is an omega-5 long chain saturated fatty acid found in abundance in the oil of pomegranate seeds. While already known to provide various health benefits from a dietary perspective, punicic acid (PA) has also been shown to be an anti-proliferation agent in various cancer cell lines such as colorectal cancer and breast cancer. In this study, we examined the effects of PA on the MCF-7 breast cancer cell line as compared to the non-cancerous MCF-10A breast epithelial cell line. We found that PA induces dose-dependent cytotoxicity on both lines, with higher cytotoxicity in MCF
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Hernández-Fernández, Javier, Andrés Mauricio Pinzón Velasco, Ellie Anne López Barrera, et al. "De novo assembly and functional annotation of blood transcriptome of loggerhead turtle, and in silico characterization of peroxiredoxins and thioredoxins." PeerJ 9 (November 18, 2021): e12395. http://dx.doi.org/10.7717/peerj.12395.

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The aim of this study was to generate and analyze the atlas of the loggerhead turtle blood transcriptome by RNA-seq, as well as identify and characterize thioredoxin (Tnxs) and peroxiredoxin (Prdxs) antioxidant enzymes of the greatest interest in the control of peroxide levels and other biological functions. The transcriptome of loggerhead turtle was sequenced using the Illumina Hiseq 2000 platform and de novo assembly was performed using the Trinity pipeline. The assembly comprised 515,597 contigs with an N50 of 2,631 bp. Contigs were analyzed with CD-Hit obtaining 374,545 unigenes, of which
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Nagy, Norbert, Gautam Malik, Aron B. Fisher, and Dipak K. Das. "Targeted disruption of peroxiredoxin 6 gene renders the heart vulnerable to ischemia-reperfusion injury." American Journal of Physiology-Heart and Circulatory Physiology 291, no. 6 (2006): H2636—H2640. http://dx.doi.org/10.1152/ajpheart.00399.2006.

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Peroxiredoxin 6 (Prdx6) is a novel peroxidase enzyme belonging to the Prdx family, which in mammals contains five more peroxiredoxins (Prdx1–Prdx5). Like glutathione peroxidase (GSHPx) and catalase, Prdx6 possesses H2O2-scavenging activities, and, like the former, it also removes hydroperoxides. Since significant amounts of catalase and GSHPx are present in the heart contributing toward the attenuation of H2O2 and hydroperoxides formed during ischemia-reperfusion injury and thereby providing cardioprotection, we asked whether Prdx6 also has any role in this process. In the present study we use
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Schröder, Ewald, Jonathan P. Brennan, and Philip Eaton. "Cardiac peroxiredoxins undergo complex modifications during cardiac oxidant stress." American Journal of Physiology-Heart and Circulatory Physiology 295, no. 1 (2008): H425—H433. http://dx.doi.org/10.1152/ajpheart.00017.2008.

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Peroxiredoxins (Prdxs), a family of antioxidant and redox-signaling proteins, are plentiful within the heart; however, their cardiac functions are poorly understood. These studies were designed to characterize the complex changes in Prdxs induced by oxidant stress in rat myocardium. Hydrogen peroxide, a Prdx substrate, was used as the model oxidant pertinent to redox signaling during health and to injury at higher concentrations. Rat hearts were aerobically perfused with a broad concentration range of hydrogen peroxide by the Langendorff method, homogenized, and analyzed by immunoblotting. Hea
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O’Flaherty, Cristian, Annie Boisvert, Gurpreet Manku, and Martine Culty. "Protective Role of Peroxiredoxins against Reactive Oxygen Species in Neonatal Rat Testicular Gonocytes." Antioxidants 9, no. 1 (2019): 32. http://dx.doi.org/10.3390/antiox9010032.

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Peroxiredoxins (PRDXs) are antioxidant enzymes that protect cells from oxidative stress and play a role in reactive oxygen species (ROS)-mediated signaling. We reported that PRDXs are critical for human fertility by maintaining sperm viability and regulating ROS levels during capacitation. Moreover, studies on Prdx6−/− mice revealed the essential role of PRDX6 in the viability, motility, and fertility competence of spermatozoa. Although PRDXs are abundant in the testis and spermatozoa, their potential role at different phases of spermatogenesis and in perinatal germ cells is unknown. Here, we
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Ayuso, Pedro, Elena García-Martín, and José A. G. Agúndez. "Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions." Antioxidants 10, no. 2 (2021): 294. http://dx.doi.org/10.3390/antiox10020294.

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Adverse drug reactions are a major cause of morbidity and mortality. Of the great diversity of drugs involved in hypersensitivity drug reactions, the most frequent are non-steroidal anti-inflammatory drugs followed by β-lactam antibiotics. The redox status regulates the level of reactive oxygen and nitrogen species (RONS). RONS interplay and modulate the action of diverse biomolecules, such as inflammatory mediators and drugs. In this review, we address the role of the redox status in the initiation, as well as in the resolution of inflammatory processes involved in drug hypersensitivity react
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Mascarenhas, Cintia, Lara Woldmar, Maria Helena Almeida, Rosangela Vieira Andrade, Anderson Ferreira Cunha, and Carmino A. De Souza. "Evaluation of Peroxiredoxins (PRDX1, PRDX2 and PRDX6) Expression in Patients with Chronic Myeloid Leukemia (CML) Treated with Imatinib in First Line." Blood 124, no. 21 (2014): 5545. http://dx.doi.org/10.1182/blood.v124.21.5545.5545.

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Abstract Introduction: Satisfactory response is present for the majority of chronic myeloid leukemia (CML) patients (pts) in chronic phase (CP) treated with tyrosine kinase inhibitors (ITK) . However, some pts exhibit suboptimal response or treatment failure. The probability of achieving optimal response may be related with several factors. The oxidative stress modulation is tightly related with the physiopathology of various hematologic diseases and can cause cell death, apoptosis and necrosis. Peroxiredoxins (Prdx) are a family of multifunctional antioxidant thioredoxin-dependent peroxidases
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Dissertations / Theses on the topic "PRDX6"

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STUCCHI, SIMONE. "Role of glucose and peroxiredoxin 6 in human chondrocytes and novel biomaterial for in vitro three-dimensional chondrocytes culture." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2020. http://hdl.handle.net/10281/261927.

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L’osteoartrite (OA) è una delle malattie reumatiche con più alta incidenza nel mondo moderno e rappresenta la pricipale cause di disabilità. L’OA è data da un disquilibrio tra degradazione e riparazione della cartilagine, a favore della degradazione, con un incremento dell’attivita degli enzimi catabolici come le matrici metalloproteinasiche. I condrociti sono responsabili della riparazione e della biosintesi degli elementi che compongono la ECM. Diversi studi supportano l’ipotesi che il diabete è uno dei fattori che causano l’osteoartrite. Sebbene non si conoscono ancor ai meccanismi molecola
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Pelletier, Jean-François. "L'inhibition de l'activité transcriptionnelle de PRDM6 diminue la migration et l'invasion de cellules de cancer ovarien épithélial." Thesis, Université Laval, 2014. http://www.theses.ulaval.ca/2014/30364/30364.pdf.

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La base moléculaire de la progression du cancer ovarien épithélial (COE) est encore peu comprise. Lors d’une étude antérieure, nous avons déterminé PRDM6 comme gène potentiellement hypométhylé dans les tumeurs de cancer ovarien de haut stade et grade comparés à des tissus normaux. L’hypométhylation n’a pas pu être confirmée, mais la surexpression de ce gène dans les tumeurs de COE laisse croire que PRDM6 peut avoir une implication dans ce cancer. L’expression de PRDM6 fut diminuée dans la lignée COE SKOV3 par la technique de l’interférence à l’ARN et des études fonctionnelles furent effectuées
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Decarpentrie, Fanny. "Etudes de gènes des chromosomes sexuels au cours de la spermatogenèse chez l'homme et la souris et implication dans la fertilite masculine." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20684.

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Les chromosomes sexuels subissent pendant la spermatogenèse de multiples modifications qui entrainent d’importantes variations dans le niveau d’expression des gènes qu’ils portent. Notamment, ils sont inactivés au cours de la méiose et la majorité reste réprimé tout au long de la spermiogenèse. Cette étude met en évidence l’existence de transcrits alternatifs particuliers de gènes sur le chromosome X et Y, dont les profils d’expressions témoignent de leur rôle au cours de ces deux phases de la spermatogenèse. Sur le chromosome X nous avons isolé, chez l’homme et chez la souris, trois gènes ubi
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Norman, Per-Gustaf. "Cloning, Purification and Crystallization of Low PSII Accumultation 19 (LPA19) and Peroxiredoxin-6 (Prx6): A Thorny Road to Diffracting Crystals." Thesis, Umeå universitet, Kemiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111548.

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Wang, Zhiqiang. "The regulatory roles of APE1 and Prdx1 interaction." Thèse, 2014. http://hdl.handle.net/1866/11830.

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L’apurinic/apyrimidic endonuclease 1 (APE1) est une protéine multifonctionnelle qui joue un rôle important dans la voie de réparation de l’ADN par excision de base. Elle sert également de coactivateur de transcription et est aussi impliquée dans le métabolisme de l’ARN et la régulation redox. APE1 peut cliver les sites AP ainsi que retirer des groupements, sur des extrémités 3’ créées suite à des bris simple brin, qui bloquent les autres enzymes de réparation, permettant de poursuivre la réparation de l’ADN, puisqu’elle possède plusieurs activités de réparation de l’ADN comme une activité phos
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Huang, Po-Chun, and 黃柏鈞. "The function of prdxI (Peroxiredoxin 1) during vascular development in zebrafish." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/81995355389320672702.

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碩士<br>國立中山大學<br>生物科學系研究所<br>104<br>The balance of reduction-oxidation (redox) has been shown acting an important role in vascular formation, especially in angiogenesis. Most studies have done in adult animals under pathological conditions, and very limited information about oxidative stress and vascular development during embryogenesis. Here, we report a novel biologi-cal function of prdx1 that play critical roles in vascular growth during zebrafish devel-opment. Prdx1 (peroxiredoxin1) belongs to a member of the peroxiredoxin family of anti-oxidant enzymes.We show prdx1 is expressed in develop
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Marques, Catarina de Almeida. "Molecular effects of continuous positive airway pressure therapy in patients with obstructive sleep apnea: a proteomics approach." Master's thesis, 2016. http://hdl.handle.net/10400.1/10024.

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Dissertação de mestrado, Biotecnologia, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2017<br>Obstructive sleep apnea (OSA) is a common public health concern in many countries, including Portugal, causing deleterious effects on metabolic and cardiovascular health. There are still, however, gaps in scientific and clinical knowledge in this field. Continuous positive airway pressure (CPAP) is considered the first line treatment in OSA, reducing co-morbidities and associated societal consequences such as accidents and cognitive impairment. However, residual sleepiness may persist i
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Books on the topic "PRDX6"

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Hutchinson. Win31/Qp 50win/Prdx Win/Wp6a Win P. Irwin, 1994.

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Hutchinson. DOS 50/Prdx 35/Q Pro 40/WP 51. Irwin, 1994.

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Book chapters on the topic "PRDX6"

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Fujita, Hiroaki. "Ferroptosis: Iron-dependent Non-apoptotic Cell Death." In Iron in Biology. Royal Society of Chemistry, 2025. https://doi.org/10.1039/9781837677979-00033.

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Ferroptosis is a form of non-apoptotic cell death induced by the iron-dependent accumulation of lipid hydroperoxides. It has been extensively studied due to its involvement in various pathological conditions, such as cancer, neurodegenerative diseases, and ischaemia–reperfusion injury. Selenoprotein glutathione peroxidase 4 (GPX4) is a critical suppressor of ferroptosis that detoxifies lipid hydroperoxides into nontoxic lipid alcohols via a catalytic selenocysteine (Sec) residue. Sec is the genetically encoded 21st amino acid, the synthesis of which is essential for life. However, the mechanis
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Conference papers on the topic "PRDX6"

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Lulek, Courtney F., Malabika Maulik, Josee Guindon, Boyd R. Rorabaugh, Angela N. Henderson-Redmond, and Daniel J. Morgan. "The Role of Peroxiredoxin 6 (PRDX6) in Cannabinoid-Induced Antinociception." In ASPET 2024 Annual Meeting Abstract. American Society for Pharmacology and Experimental Therapeutics, 2024. http://dx.doi.org/10.1124/jpet.501.925280.

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Sundar, Isaac Kirubakaran, Sangwoon Chung, Jaewoong Hwang, et al. "Targeted Disruption Of Prdx6 Does Not Show Increased Susceptibility To Cigarette Smoke-mediated Lung Inflammation And Emphysema In Mouse Lung." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1351.

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Wei, Tingting, Xiaocen Wang, Ke Lang, and Dong Yang. "The effects and mechanisms of PRDX6 on alleviating epithelial ferroptosis in COPD through enhancing the stability of ferritin and inhibiting its ferritinophagy." In ERS Congress 2024 abstracts. European Respiratory Society, 2024. http://dx.doi.org/10.1183/13993003.congress-2024.pa4399.

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Jain, Pallavi, Azin Sayad, Erik Mollen, et al. "Abstract 883: PRDX4 as a novel target for pancreatic cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-883.

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Jain, Pallavi, Azin Sayad, Erik Mollen, et al. "Abstract 883: PRDX4 as a novel target for pancreatic cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-883.

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Fulco, Natalie, Sophia Fagan, and Shelley A. Phelan. "Abstract 1872: Oleuropein reduces Prdx1 expression, cell proliferation and viability in K562 human leukemia cells." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-1872.

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Fulco, Natalie, Sophia Fagan, and Shelley A. Phelan. "Abstract 1872: Oleuropein reduces Prdx1 expression, cell proliferation and viability in K562 human leukemia cells." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-1872.

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Xinrui, Ji, Sun Annan, Wu Kexin, and Hu Ran. "Inhibition of Mdm2 ubiquitin-ligase activity by PRDX1 leads to the activation of p53 tumor suppressor." In ISAIMS 2021: 2nd International Symposium on Artificial Intelligence for Medicine Sciences. ACM, 2021. http://dx.doi.org/10.1145/3500931.3500970.

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Wang, Sen, Zheng Chen, Heng Lu, et al. "Abstract 885: Induction of PRDX2 by H. pylori reduces ROS and promotes cancer cell survival and resistance to cisplatin." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-885.

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Wang, Sen, Zheng Chen, Heng Lu, et al. "Abstract 885: Induction of PRDX2 by H. pylori reduces ROS and promotes cancer cell survival and resistance to cisplatin." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-885.

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