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Journal articles on the topic 'Pre-Analytical requirements'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Vermeersch, Pieter, Glynis Frans, Alexander von Meyer, Seán Costelloe, Giuseppe Lippi, and Ana-Maria Simundic. "How to meet ISO15189:2012 pre-analytical requirements in clinical laboratories? A consensus document by the EFLM WG-PRE." Clinical Chemistry and Laboratory Medicine (CCLM) 59, no. 6 (2021): 1047–61. http://dx.doi.org/10.1515/cclm-2020-1859.

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Abstract The International Organization for Standardization (ISO) 15189:2012 standard aims to improve quality in medical laboratories through standardization of all key elements in the total testing process, including the pre-analytical phase. It is hence essential that accreditation bodies, assessing laboratories against ISO15189:2012, pay sufficient attention to auditing pre-analytical activities. However, there are significant differences in how technical auditors interpret the pre-analytical requirements described in ISO15189:2012. In this consensus document, the European Federation of Cli

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Dagher, Georges, Karl-Friedrich Becker, Serena Bonin, et al. "Pre-analytical processes in medical diagnostics: New regulatory requirements and standards." New Biotechnology 52 (September 2019): 121–25. http://dx.doi.org/10.1016/j.nbt.2019.05.002.

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Krčmová, Lenka Kujovská, Bohuslav Melichar, and František Švec. "Chromatographic methods development for clinical practice: requirements and limitations." Clinical Chemistry and Laboratory Medicine (CCLM) 58, no. 11 (2020): 1785–93. http://dx.doi.org/10.1515/cclm-2020-0517.

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AbstractDevelopment of a chromatographic method in bioanalysis is a challenging and complex procedure with many pitfalls and often unexpected reversals that can require several months to accomplish. Even an experienced analytical team must contend many limitations mainly in connection with the strict requirements imposed on current clinical research. These restrictions typically persist throughout the whole development process, from clinical trial assignment, across optimization of extraction of biological materials and chromatographic separation, to validation and data interpretation. This pa

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Pietruczuk, Mirosława, Łukasz Kraszula, Anna Jasińska, Piotr Kuna, and Makandjou-Ola Eusebio. "The usefulness of quality indicators of preanalitical phase in medical labs, according to the Quality standards requirements, ISO 15189:2013 and WG-LEPS recommendation, Jan 2017." Diagnostyka Laboratoryjna 55, no. 2 (2019): 113–20. http://dx.doi.org/10.5604/01.3001.0013.7453.

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This paper presents the usefulness of pre-analytical process in medical diagnostic laboratories, recommended by WG-LEPS, according to departmental requirements and ISO 15189, with regard to clinical hospital laboratory. It is known that the pre-analytical process generates over 70% of all laboratory errors. The tested materials are laboratory test referrals data for a period of one year (2017), mainly from the Laboratory Information Management System. The study includes the mean annual pre-laboratory error rates. The results showed low error rates in the areas related to the laboratory testing

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Kristoffersen, Ann Helen, Anne V. Stavelin, Eva Ajzner, et al. "Pre-analytical practices for routine coagulation tests in European laboratories. A collaborative study from the European Organisation for External Quality Assurance Providers in Laboratory Medicine (EQALM)." Clinical Chemistry and Laboratory Medicine (CCLM) 57, no. 10 (2019): 1511–21. http://dx.doi.org/10.1515/cclm-2019-0214.

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Abstract Background Correct handling and storage of blood samples for coagulation tests are important to assure correct diagnosis and monitoring. The aim of this study was to assess the pre-analytical practices for routine coagulation testing in European laboratories. Methods In 2013–2014, European laboratories were invited to fill in a questionnaire addressing pre-analytical requirements regarding tube fill volume, citrate concentration, sample stability, centrifugation and storage conditions for routine coagulation testing (activated partial thromboplastin time [APTT], prothrombin time in se

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Kutlija, Nevena. "Hemolysis - a constant source of error in laboratory diagnostics // Hemoliza – stalni izvor greške u laboratorijskoj dijagnostici." SESTRINSKI ŽURNAL 4, no. 1 (2017): 55. http://dx.doi.org/10.7251/sez0117055k.

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The aim of this paper is to point out the importance of proper pre-analytical preparation of the sample in order to reduce the number of errors in the laboratory with a special emphasis on hemolysis. In recent years, the lab has become more efficient in terms of faster results, more precise, faster and more precise controls, all due to automation, but it needs to be cautious as errors continue to occur. The largest share of errors occurs in the pre-analytic and post-analytical phase. The erythrocyte hemolysis in vivo or in vitro is one of the most significant errors in the preanalytic phaseThi

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Snyder, James W. "Blood Cultures: the Importance of Meeting Pre-Analytical Requirements in Reducing Contamination, Optimizing Sensitivity of Detection, and Clinical Relevance." Clinical Microbiology Newsletter 37, no. 7 (2015): 53–57. http://dx.doi.org/10.1016/j.clinmicnews.2015.03.001.

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Konstandatos, Otto. "Fair-value analytical valuation of reset executive stock options consistent with IFRS9 requirements." Annals of Actuarial Science 14, no. 1 (2020): 188–218. http://dx.doi.org/10.1017/s1748499519000125.

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AbstractExecutive stock options (ESOs) are widely used to reward employees and represent major items of corporate liability. The International Accounting Standards Board IFRS9 financial reporting standard which came into full effect on 1-Jan 2018, along with its Australian implementation AASB9, requires public corporations to report their fair-value cost in financial statements. Reset ESOs are typically issued to re-incentivise employees by allowing the option to be cancelled and re-issued with a lower exercise price or later maturity. We produce a novel analytical Reset ESO valuation consiste

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Athanasiadou, Zoi S., Antonia Mourtzikou, Marilena Stamouli, and Petros Karkalousos. "Quality Indicators for the Performance Evaluation at a Biochemistry Laboratory." International Journal of Reliable and Quality E-Healthcare 9, no. 2 (2020): 18–33. http://dx.doi.org/10.4018/ijrqeh.2020040102.

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The use of quality indicators and risk evaluation are valuable tools for maintaining the quality of laboratory tests. There are both requirements of ISO 15189: 2012 and are usually based on common statistical and empirical data. The purpose of the present study was the quality quantification and risk evaluation through the collection, study, and analysis of quality indicators covering the pre-analytical, analytical, and post-analytical phases of the laboratory testing process. Statistical data was collected for the period from 1/12/2017 to 28/2/2018, using the LIS of Biochemical Laboratory. QI

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Knight, D., R. Singer, J. M. White, and C. G. Fraser. "Laboratory evaluation of the Du Pont "Dimension Clinical Chemistry System"." Clinical Chemistry 34, no. 9 (1988): 1899–903. http://dx.doi.org/10.1093/clinchem/34.9.1899.

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Abstract We evaluated the analytical performance of the Du Pont Dimension Clinical Chemistry System to assess its suitability as a replacement for the Du Pont aca III, currently routinely used for analysis of pediatric, high-risk, and emergency specimens. Twenty-six analyses were studied. These generally fulfilled pre-set analytical goals for precision based on biological variation or "state of the art." Significant economies were achieved and we found the Dimension to be reliable, easy to operate, and simple to maintain. It also fulfilled safety requirements for analysis of specimens of high

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Rossi, Esther Diana, and Fernando Schmitt. "Pre-analytic steps for molecular testing on thyroid fine-needle aspirations: The goal of good results." CytoJournal 10 (November 28, 2013): 24. http://dx.doi.org/10.4103/1742-6413.122300.

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Fine-needle aspiration cytology (FNAC) represents a valid alternative to biopsy in a variety of clinical settings mainly based on its simplicity and less invasive clinical approach. In some cases, morphology evaluation alone is not sufficient to manage the patients, so that the application of ancillary techniques can contribute to diagnosis, prognosis and prediction of tumor behavior. These techniques include polymerase chain reaction (PCR), fluorescence in situ hybridization (FISH), in situ PCR, direct Sequencing, microarrays and proteomic methodologies. Although several recent experiences un

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El seidy, Mansour, and Iman Alazab. "A proposed program in light of the requirements of the Integrated Science Approach (STEM) to develop the professional and academic performance of secondary school science and mathematics teachers." International Journal of research in Educational Sciences 4, no. 2 (2021): 195–288. http://dx.doi.org/10.29009/ijres.4.2.6.

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The current study aimed to identify the effectiveness of a proposed program to develop the professional and academic performance of science and mathematics teachers in the light of the entrance to the integration between science, technology, engineering and mathematics (STEM), by preparing a list of requirements for building a proposed program for science and mathematics teachers in the light of STEM education, and from Then building the proposed program based on these requirements, and the researchers used the descriptive analytical approach to describe and analyze research and studies relate

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Katser, Iurii D., Vyacheslav O. Kozitsin, Ivan V. Maksimov, Denis A. Larionov, and Konstantin I. Kotsoev. "Data pre-processing methods for NPP equipment diagnostics algorithms: an overview." Nuclear Energy and Technology 7, no. 2 (2021): 111–25. http://dx.doi.org/10.3897/nucet.7.63675.

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The main tasks of diagnostics at nuclear power plants are detection, localization, diagnosis, and prognosis of the development of malfunctions. Analytical algorithms of varying degrees of complexity are used to solve these tasks. Many of these algorithms require pre-processed input data for high-quality and efficient operation. The pre-processing stage can help to reduce the volume of the analyzed data, generate additional informative diagnostic features, find complex dependencies and hidden patterns, discard uninformative source signals and remove noise. Finally, it can produce an improvement

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Boone, D. J. "Governmental perspectives on evaluating laboratory performance." Clinical Chemistry 39, no. 7 (1993): 1461–67. http://dx.doi.org/10.1093/clinchem/39.7.1461.

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Abstract The quality of laboratory analytical performance required to support medical decision-making has been defined in four major ways: (a) by the analytical variance of the state of the practice; (b) by the total variance, including analytical and biological variability; (c) by the loss of diagnostic efficiency attributable to analytical error; and (d) by medical-usefulness criteria. From the federal government's perspective, the answer to the question "How good must a laboratory test result be to be medically relevant?" must take into account the clinical context of the test, with accompa

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Collie, Jake T. B., Ronda F. Greaves, Oliver A. H. Jones, Glenn Eastwood, and Rinaldo Bellomo. "Vitamin C measurement in critical illness: challenges, methodologies and quality improvements." Clinical Chemistry and Laboratory Medicine (CCLM) 58, no. 4 (2020): 460–70. http://dx.doi.org/10.1515/cclm-2019-0912.

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AbstractBackgroundThere is renewed interest in high-dose vitamin C interventions in clinical medicine due to its antioxidant properties, safe use and cost-effectiveness. Yet, randomised control trials (RCTs) employing these interventions are failing to include robust analytical methodology and proper sample handling and processing techniques. Consequently, comparisons between studies becomes impossible as there is no metrological traceability and results may be prone to pre-analytical errors.ContentThrough published vitamin C stability studies, method comparison papers and data from vitamin C

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Ali, A. "Contamination of Alluvial Aquifers by Metal Industries in Parts of Central Ganga Basin, India." Water Science and Technology 26, no. 9-11 (1992): 2321–24. http://dx.doi.org/10.2166/wst.1992.0726.

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Physicochemical characteristics of wastewater from metal industries in parts of central Ganga basin, district Aligarh, India and the differential accumulation of heavy metals in shallow aquifers were investigated. It has been observed through analytical results that the concentration of heavy metals like Fe, Cu, Mn, Cd and Pb are higher than the suggested guidelines of World Heath Organisation, 1985 both in wastewater and shallow groundwater. Since groundwater is the only source of water supply for drinking, agricultural and industrial requirements, it is an essential pre-requisite that the ex

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Lachenal, X., P. M. Weaver, and S. Daynes. "Multi-stable composite twisting structure for morphing applications." Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences 468, no. 2141 (2012): 1230–51. http://dx.doi.org/10.1098/rspa.2011.0631.

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Conventional shape-changing engineering structures use discrete parts articulated around a number of linkages. Each part carries the loads, and the articulations provide the degrees of freedom of the system, leading to heavy and complex mechanisms. Consequently, there has been increased interest in morphing structures over the past decade owing to their potential to combine the conflicting requirements of strength, flexibility and low mass. This article presents a novel type of morphing structure capable of large deformations, simply consisting of two pre-stressed flanges joined to introduce t

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Aloraini, Seham Abdulrahman Sulayman. "Development of Mathematics Teacher’s Preparation Programs in the Light of STEM Education." Journal of Education and Training Studies 8, no. 4 (2020): 10. http://dx.doi.org/10.11114/jets.v8i4.4707.

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The study aimed to reveal the reality of keeping pace with the preparation programs of mathematics teachers to the requirements of STEM education and develop a suggested scenario for the development of mathematics teacher preparation programs in the light of the requirements of STEM. To this end, the analytical descriptive method was conducted, and the researcher built a list of requirements in the light of STEM education which should be included in the programs of preparation of mathematics teachers. The questionnaire was used as a data collection tool. The study sample consisted of (47) facu

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Brierley, Sam, Anthony Adlam, and Matthew Hall. "Quantification of Ethanedinitrile in Air Using a New and Accurate Gas Chromatography Method." Methods and Protocols 2, no. 1 (2018): 1. http://dx.doi.org/10.3390/mps2010001.

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Compared to previously tested fumigants such as methyl bromide, sulfuryl fluoride and phosphine; ethanedinitrile (EDN) is a new fumigant which is being trialled around the world as a pre-plant soil treatment and as a quarantine and pre-shipment (QPS) treatment of commodities. To collect the data necessary to assess the effectiveness of this fumigant, an accurate analytical method is needed across a wide concentration range. We reviewed the methods of detection for EDN described in recently published fumigation studies and have developed and validated a method to quantify EDN in air using a gas

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Okojie, J. A., A. E. Effiom, E. N. Tawiah, and I. J. Akpejiori. "COMPUTATIONAL TIME MODELLING FOR TREE CROWN EXTRACTION FROM HIGH RESOLUTION IMAGERY USING GEOGRAPHIC OBJECT-BASED IMAGE ANALYSIS." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLII-2/W13 (June 4, 2019): 483–88. http://dx.doi.org/10.5194/isprs-archives-xlii-2-w13-483-2019.

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<p><strong>Abstract.</strong> Image segmentation, unlike most conventional approaches, assesses image pixel information in relation to image contextual information to extract congruent image objects. A comprehensive review of literature during the research conceptualization phase revealed that while a lot of work has been done into the optimization of the segmentation computational time, there was a conspicuous research gap in the area of computational time modelling and pre-analytical projections.</p><p>The focus of this research was, therefore, to model the comp

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Frigerio, Roberto, Angelo Musicò, Marco Brucale, et al. "Extracellular Vesicles Analysis in the COVID-19 Era: Insights on Serum Inactivation Protocols towards Downstream Isolation and Analysis." Cells 10, no. 3 (2021): 544. http://dx.doi.org/10.3390/cells10030544.

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Since the outbreak of the COVID-19 crisis, the handling of biological samples from confirmed or suspected SARS-CoV-2-positive individuals demanded the use of inactivation protocols to ensure laboratory operators’ safety. While not standardized, these practices can be roughly divided into two categories, namely heat inactivation and solvent-detergent treatments. These routine procedures should also apply to samples intended for Extracellular Vesicles (EVs) analysis. Assessing the impact of virus-inactivating pre-treatments is therefore of pivotal importance, given the well-known variability int

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Michalski, Jan P. "Parametric Method For Evaluating Optimal Ship Deadweight." Polish Maritime Research 21, no. 2 (2014): 3–8. http://dx.doi.org/10.2478/pomr-2014-0013.

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Abstract The paper presents a method of choosing the optimal value of the cargo ships deadweight. The method may be useful at the stage of establishing the main owners requirements concerning the ship design parameters as well as for choosing a proper ship for a given transportation task. The deadweight is determined on the basis of a selected economic measure of the transport effectiveness of ship - the Required Freight Rate (RFR). The mathematical model of the problem is of a deterministic character and the simplifying assumptions are justified for ships operating in the liner trade. The ass

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Tsonos, Alexander-Dimitrios, George Kalogeropoulos, Pantelis Iakovidis, Marios-Zois Bezas, and Michail Koumtzis. "Seismic Performance of RC Beam–Column Joints Designed According to Older and Modern Codes: An Attempt to Reduce Conventional Reinforcement Using Steel Fiber Reinforced Concrete." Fibers 9, no. 7 (2021): 45. http://dx.doi.org/10.3390/fib9070045.

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An analytical and experimental investigation was conducted herein to examine the cyclic load behavior of beam–column joint subassemblages, typical of both the modern reinforced concrete (RC) structures and of the pre-1960s–1970s existing ones. Seven exterior RC beam–column joint subassemblages were constructed and subjected to earthquake-type loading. Three specimens were designed according to the requirements of the Eurocode (EC) for ductility class medium (DCM), while the other three specimens possessed poor seismic details, conforming to past building codes. The hysteresis behavior of the s

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Zhelankin, Andrey V., Daria A. Stonogina, Sergey V. Vasiliev, et al. "Circulating Extracellular miRNA Analysis in Patients with Stable CAD and Acute Coronary Syndromes." Biomolecules 11, no. 7 (2021): 962. http://dx.doi.org/10.3390/biom11070962.

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Extracellular circulating microRNAs (miRNAs) are currently a focus of interest as non-invasive biomarkers of cardiovascular pathologies, including coronary artery disease (CAD) and acute coronary syndromes (ACS): myocardial infarction with and without ST-segment elevation (STEMI and NSTEMI) and unstable angina (UA). However, the current data for some miRNAs are controversial and inconsistent, probably due to pre-analytical and methodological variances in different studies. In this work, we fulfilled the basic pre-analytical requirements provided for circulating miRNA studies for application to

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Paro, M. M. Kardum, S. Perkov, Z. Šiftar, and A. Radeljak. "Role of laboratory in improving pre- analytical quality and patient safety: Impact of educational activities on sample collection based on the ISO 15189 requirements and the national recommendations." Clinica Chimica Acta 493 (June 2019): S702. http://dx.doi.org/10.1016/j.cca.2019.03.1554.

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Єршов, Микола. "DIGITALISATION OF PROFESSIONAL (VOCATIONAL) AND PRE-HIGH TERTIARY EDUCATION: PROBLEMS AND PROSPECTS." Науковий вісник Інституту професійно-технічної освіти НАПН України. Професійна педагогіка, no. 18 (June 24, 2019): 67–74. http://dx.doi.org/10.32835/2223-5752.2019.18.67-74.

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The national professional (vocational) and pre-high tertiary education are represented based on the analisys national legislation, the materials of Ukrainian and foreign mass-media, scientific articles on reforming education system issues, statistic data of Ministry of Education and Science of Ukraine, State Statistics Service of Ukraine, State Employment Service, the Internet-sources (HeadHanter, UNESCO Database, Approved Event (UFI), Eurostat Educational Statistics), VET schools and colleges web-sites, analytical materials the Institute of vocational education of the National academy of educ

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Kapil P. Sawarkar and Pramod Shah. "Role of Computed Tomography in Predicting Severity of Acute Pancreatitis." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 4039–46. http://dx.doi.org/10.26452/ijrps.v11i3.2601.

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The current study was based on Computed Tomography (CT) findings and results. We found 63% of patients with acute interstitial edematous pancreatitis, and we found 37% of patients with acute necrotic pancreatitis in 46 cases. Based on our findings, we observed bulky pancreas among 26 cases (56.52%), 17 cases (36.95%) of pancreatic necrosis, 9 cases of pancreatic atrophy, 11 cases of pseudocyst, and 9 cases of peri-pancreatic fluid. When we evaluated the Modified CT Severity index among the study cases, we observed that 19.56% cases have mild index, the majority (56.52% cases) have moderate ind

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Zhelankin, Andrey V., Sergey V. Vasiliev, Daria A. Stonogina, et al. "Elevated Plasma Levels of Circulating Extracellular miR-320a-3p in Patients with Paroxysmal Atrial Fibrillation." International Journal of Molecular Sciences 21, no. 10 (2020): 3485. http://dx.doi.org/10.3390/ijms21103485.

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The potential of extracellular circulating microRNAs (miRNAs) as non-invasive biomarkers of atrial fibrillation (AF) has been confirmed by a number of recent studies. However, the current data for some miRNAs are controversial and inconsistent, probably due to pre-analytical and methodological differences. In this work, we attempted to fulfill the basic pre-analytical requirements provided for circulating miRNA studies for application to paroxysmal atrial fibrillation (PAF) research. We used quantitative PCR (qPCR) to determine the relative plasma levels of circulating miRNAs expressed in the

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Stan, A., E. Bell, P. Schoonheim, and E. Mysler. "THU0652-HPR ONLINE EDUCATION YIELDS SIGNIFICANT GAINS IN RHEUMATOLOGISTS’ KNOWLEDGE OF BIOLOGICS AND BIOSIMILARS BUT A SUBSTANTIAL GAP REMAINS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 570.2–571. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6048.

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Background:Biologics are complex proteins which have revolutionized the treatment of many serious diseases. Due to their complexity and manufacturing which involves living organisms, it is not possible to create identical versions of reference biologics, but it is possible to create biosimilar drugs. Biosimilars have the potential to yield high cost savings and expand treatment options to meet the growing demand for biological therapies.Objectives:This study assessed whether the online CME-accredited round-table-discussion titled “Understanding Biologics: from protein to clinical practice” imp

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Pisarek, M., A. Roguska, L. Marcon, M. Andrzejczuk, and M. Janik-Czachor. "Enhanced Bioactivity of Calcium Phosphate Coatings Obtained by a Direct Electrodeposition from Hanks’ Solution on Ti Surface / Zwiekszona Bioaktywnosc Powłok Fosforanowo-Wapniowych Otrzymanych Metoda Bezposredniego Elektroosadzania Na Powierzchni Ti Z Roztworu Hanka." Archives of Metallurgy and Materials 58, no. 1 (2013): 261–67. http://dx.doi.org/10.2478/v10172-012-0183-4.

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The main requirements for titanium biomaterials are: (a) biocompatibility, (b) resistance to biological corrosion and (c) antisepticity. These requirements may be met by a new generation of titanium biomaterials with a specific surface layer of strictly defined microstructure, chemical and phase composition. Recently, various surface modifications have been applied to form a bioactive layer on Ti surface, which is known to accelerate osseointegration. The purpose of this study was to investigate bioactivity of porous calcium phosphate coatings prepared by a direct electrodeposition on Ti surfa

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Weissgerber, Sophia C., Matthias Brunmair, and Ralf Rummer. "Null and Void? Errors in Meta-analysis on Perceptual Disfluency and Recommendations to Improve Meta-analytical Reproducibility." Educational Psychology Review 33, no. 3 (2021): 1221–47. http://dx.doi.org/10.1007/s10648-020-09579-1.

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AbstractIn the 2018 meta-analysis of Educational Psychology Review entitled “Null effects of perceptual disfluency on learning outcomes in a text-based educational context” by Xie, Zhou, and Liu, we identify some errors and inconsistencies in both the methodological approach and the reported results regarding coding and effect sizes. While from a technical point of view the meta-analysis aligns with current meta-analytical guidelines (e.g., PRISMA) and conforms to general meta-analytical requirements (e.g., considering publication bias), it exemplifies certain insufficient practices in the cre

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Barnes, Rebecca O., and Peter H. Watson. "Precision medicine: Driving the evolution of biobanking quality." Healthcare Management Forum 33, no. 3 (2020): 102–6. http://dx.doi.org/10.1177/0840470419898874.

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The promise of precision medicine will only be realized if the healthcare system adapts to meet some key infrastructure needs. Among these needs are adequate biobanking practices, capable of producing the biological samples and data that precision medicine relies upon in both the research and clinical phases. Within the research domain, there have been significant improvements to biobanking processes over the past two decades, driven by increased understanding of the impact of pre-analytical variability and the critical role of biospecimen and data quality. In the era of precision medicine, bi

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Michalski, Jan P. "Parametrical Method for Determining Optimal Ship Carrying Capacity and Performance of Handling Equipment." Polish Maritime Research 23, no. 2 (2016): 19–24. http://dx.doi.org/10.1515/pomr-2016-0016.

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Abstract The paper presents a method of evaluating the optimal value of the cargo ships deadweight and the coupled optimal value of cargo handling capacity. The method may be useful at the stage of establishing the main owners requirements concerning the ship design parameters as well as for choosing a proper second hand ship for a given transportation task. The deadweight and the capacity are determined on the basis of a selected economic measure of the transport effectiveness of ship – the Required Freight Rate. The mathematical model of the problem is of a deterministic character and the si

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Kutsenko, O. I., V. D. Yakovenko, and Ye O. Yakovenko. "EVALUATION OF QUALITY MANAGEMENT SYSTEMS." Scientific Notes of Junior Academy of Sciences of Ukraine, no. 3(19) (2020): 59–70. http://dx.doi.org/10.51707/2618-0529-2020-19-07.

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The article defines the essence of the concepts “assessment” and “internal audit” of the quality assurance system, the requirements of international ISO standards for the formation of an internal system for evaluating the effectiveness of management systems are analyzed, highlights the main aspects of the formation of the program and plan of internal audit, the competence of auditors, proposes a method of expert assessment in the quality management system of educational institutions in the context of a real educational process, proposes automated information and analytical management system. T

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Kohlhagen, Mindy, Surendra Dasari, Maria Willrich, et al. "Automation and validation of a MALDI-TOF MS (Mass-Fix) replacement of immunofixation electrophoresis in the clinical lab." Clinical Chemistry and Laboratory Medicine (CCLM) 59, no. 1 (2021): 155–63. http://dx.doi.org/10.1515/cclm-2020-0581.

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AbstractObjectivesA matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) method (Mass-Fix) as a replacement for gel-based immunofixation (IFE) has been recently described. To utilize Mass-Fix clinically, a validated automated method was required. Our aim was to automate the pre-analytical processing, improve positive specimen identification and ergonomics, reduce paper data storage and increase resource utilization without increasing turnaround time.MethodsSerum samples were batched and loaded onto a liquid handler along with reagents and a barcoded sampl

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Morales-Palma, Domingo, Marcos Borrego, Andrés Martínez-Donaire, Gabriel Centeno, and Carpóforo Vallellano. "Optimization of Hole-Flanging by Single Point Incremental Forming in Two Stages." Materials 11, no. 10 (2018): 2029. http://dx.doi.org/10.3390/ma11102029.

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Single point incremental forming (SPIF) has been demonstrated to accomplish current trends and requirements in industry. Recent studies have applied this technology to hole-flanging by performing different forming strategies using one or multiple stages. In this work, an optimization procedure is proposed to balance fabrication time and thickness distribution along the produced flange in a two-stage variant. A detailed analytical, numerical and experimental investigation is carried out to provide, evaluate and corroborate the optimal strategy. The methodology begins by analysing the single-sta

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Litvinova, O. G., and T. G. Cheshuina. "ARCHITECTURAL DESIGN METHOD OF MODERN BUILDINGS IN HISTORICAL TOMSK." Vestnik Tomskogo gosudarstvennogo arkhitekturno-stroitel'nogo universiteta. JOURNAL of Construction and Architecture, no. 2 (April 29, 2019): 63–75. http://dx.doi.org/10.31675/1607-1859-2019-21-2-63-75.

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Pre-project studies in modern building design in the historical and architectural urban environment is relevant to architects, as the city-planning requirements are systematically updated and complicated. A special attention is paid to the analysis of international documents, which formulate objective approaches to preservation of the unique architectural and artistic images of the urban environment. The purpose of this study is to concretize the list of research works for identification of the architectural design standards in the historical environment. The events and the standards are formu

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van Rossum, Huub H., and Hans Kemperman. "Implementation and application of moving average as continuous analytical quality control instrument demonstrated for 24 routine chemistry assays." Clinical Chemistry and Laboratory Medicine (CCLM) 55, no. 8 (2017): 1142–51. http://dx.doi.org/10.1515/cclm-2016-0696.

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Abstract Background: General application of a moving average (MA) as continuous analytical quality control (QC) for routine chemistry assays has failed due to lack of a simple method that allows optimization of MAs. A new method was applied to optimize the MA for routine chemistry and was evaluated in daily practice as continuous analytical QC instrument. Methods: MA procedures were optimized using an MA bias detection simulation procedure. Optimization was graphically supported by bias detection curves. Next, all optimal MA procedures that contributed to the quality assurance were run for 100

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Bartko, Robert, and András Payrich. "Comparative Study on the Pre-trial Detention with Reference to the New Hungarian Code on Criminal Procedure." International and Comparative Law Review 17, no. 2 (2017): 169–78. http://dx.doi.org/10.2478/iclr-2018-0022.

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Summary The decision of legislating the new Criminal Procedure Code made by the Hungarian Government in 2015 was necessary with special reference to the new forms of criminality and criminal investigation. The conception of the new Code on Criminal Procedure (hereinafter: new Code) was accepted by the Government on 11 February in 2015. The directives of the conception were the followings: efficiency, rapidity, simplicity, up-to-dateness, coherency and expediency. Not only the European but also the international requirements and the Hungarian legal traditions were followed by the legislation. T

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Pokrovskaya, M. S., A. L. Borisova, O. V. Sivakova, et al. "QUALITY MANAGEMENT IN BIOBANK. WORLD TENDENCIES AND EXPERIENCE OF BIOBANK OF FSI «NMRC FOR PREVENTIVE MEDICINE» OF THE MINISTRY OF HEALTHCARE OF RUSSIA." Russian Clinical Laboratory Diagnostics 64, no. 6 (2019): 380–84. http://dx.doi.org/10.18821/0869-2084-2019-64-6-380-384.

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This paper provides several definitions of the term “biobank”; a list of standards developed by the International Organization for Standardization (ISO) applicable to the activities of biobanks; analyzes the legal and ethical requirements; the Russian legal framework in the field of biobanking, the best international practices and recommendations; describes the experience of the development and implementation of quality management systems according to ISO 9001 in Biobanks established in different countries, and the experience of the Bank of Biological Material of the National Medical Research

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Baber, Ronny, and Michael Kiehntopf. "Automation in biobanking from a laboratory medicine perspective." Journal of Laboratory Medicine 43, no. 6 (2019): 329–38. http://dx.doi.org/10.1515/labmed-2019-0151.

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Abstract Biobanks are important infrastructures to support clinical research and developments in personalized medicine. Although biobanking is not a new invention it has gained importance in the last few years due to increased quality requirements for biological samples in biomedical research and new high resolution Omics-technologies. Moreover, quality-assured collection, processing and storage of biological samples with defined pre-analytical history plays a key role for reproducibility in scientific research and paves the path towards precision medicine. Due to the increasing need for large

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Demoiny, Sara B. "Social studies teacher educators who do race work." Social Studies Research and Practice 13, no. 3 (2018): 330–44. http://dx.doi.org/10.1108/ssrp-04-2018-0017.

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Purpose The purpose of this paper is to explore how 11 social studies teacher educators (SSTEs) incorporated race into their social studies methods courses. It examines the instructional practices of the SSTEs using racial-pedagogical-content-knowledge (RPCK) as an analytical framework. Design/methodology/approach The paper is a qualitative interview study. The data sources included two 40–90 min semi-structured interviews per participant, methods course syllabi and reading lists, and university documents such as departmental mission statements and program course requirements. Data were analyz

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Adeyeye, Emmanuel Ilesanmi. "Simultaneous Identification and Evaluation of Amino Acid Profiles of the Male and Female Innards of Neopetrolisthes maculatus." International Letters of Natural Sciences 75 (May 2019): 13–26. http://dx.doi.org/10.18052/www.scipress.com/ilns.75.13.

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This article reports the amino acid profiles of the innards of the male and female dry samples ofN. maculatuscollected from the Atlantic Ocean at Orimedu beach in Ibeju-Lekki, Lagos, Nigeria. The analytical results showed high values of amino acids being observed in both heterosexual samples (g 100g-1protein): 8.17-8.32 (Leu), 8.35-10.3 (Asp), 17.6-18.2 (Glu) and 7.76-9.55 (Arg) with total amino acid values being greater in female innards (97.6g100g-1) than the male innards (95.5g 100g-1). These quality parameters were instructive of the quality of the amino acids in the innards ofN. maculatus

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Shi, Leimin, Amanda Baker, and Honglin Chen. "Chinese EFL Teachers’ Cognition about the Effectiveness of Genre Pedagogy: A Case Study." RELC Journal 50, no. 2 (2017): 314–32. http://dx.doi.org/10.1177/0033688217716506.

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Developing students’ communicative competence became the primary goal of the current College English Curriculum Requirements in 2004 in China. There has been increasing concern, however, that this goal has yet to be realized, particularly in relation to the teaching of writing. This study investigated the potential of a Systemic Functional Linguistics (SFL-) informed genre approach to enhance Chinese students’ communicative competence in writing. As teachers’ beliefs have a strong impact on the effectiveness of their teaching practice (Borg, 2003), the study examined six Chinese College Englis

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Wang, F., X. Zhao, D. Zhang, Y. Wu, B. Shirinzadeh, and Y. Tian. "Design and control of a high-acceleration precision positioning system using a novel flexible decoupling mechanism." Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 224, no. 2 (2010): 431–42. http://dx.doi.org/10.1243/09544062jmes1793.

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This article presents a high-acceleration precision positioning system to improve the efficiency and precision of micro-electro-mechanical system (MEMS) packaging. The positioning system is direct driven by linear voice coil actuators (LVCAs), and the mass and inertia of the motion system are significantly reduced by using a novel flexible decoupling mechanism based on flexure hinges. The decoupling principle of the mechanism is introduced, and the flexure hinges are designed by using an analytical method. Through dynamic analysis, the stiffness and preload of the spring are determined. With t

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Moskovenko, Nadezhda, Sergey Tikhonov, Nataliya Tikhonova, and Askar Muratov. "Unified Standards of the Eurasian Economic Union for Fruit and Vegetable Products as a Means of Integrated Trade in the Global Economic Environment." Food Processing: Techniques and Technology 50, no. 3 (2020): 559–74. http://dx.doi.org/10.21603/2074-9414-2020-3-559-574.

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Introduction. A unified system of normative and technical regulation can facilitate export of fruit and vegetables. The research objective was to develop a draft of unified standards for marketing regulation and quality control of fruit and vegetable products that participate in foreign trade in the Eurasian Economic Union (EAEU). Study objects and methods. The study featured draft standards for quality of prepared and packaged food products, classification, size, labeling, packaging, safety indicators, etc. The research also included development programs of interstate standards for tech

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Kahana-Edwin, Smadar, Lucy E. Cain, Geoffrey McCowage, et al. "Neuroblastoma Molecular Risk-Stratification of DNA Copy Number and ALK Genotyping via Cell-Free Circulating Tumor DNA Profiling." Cancers 13, no. 13 (2021): 3365. http://dx.doi.org/10.3390/cancers13133365.

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Background: MYCN amplification (MNA), segmental chromosomal aberrations (SCA) and ALK activating mutations are biomarkers for risk-group stratification and for targeted therapeutics for neuroblastoma, both of which are currently assessed on tissue biopsy. Increase in demand for tumor genetic testing for neuroblastoma diagnosis is posing a challenge to current practice, as the small size of the core needle biopsies obtained are required for multiple molecular tests. We evaluated the utility of detecting these biomarkers in the circulation. Methods: Various pre-analytical conditions tested to op

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Alves de Sousa, Nuno, Markus Kintscher, and Afzal Suleman. "Morphing of an adaptive shock control bump using pressurized chambers." Journal of Intelligent Material Systems and Structures 31, no. 15 (2020): 1821–37. http://dx.doi.org/10.1177/1045389x20932214.

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The dawn of research on shock and boundary layer interaction control dates back to the 1970s, when humped transonic aerofoils were first studied as a means to improve the performance of supercritical aerofoil technology at off-design conditions. Since then, shock control bumps have been found to be promising devices for such kind of flow control. They have a smearing effect on the shock wave structure achieved through isentropic pre-compression of the flow upstream of the main shock and can significantly lower wave drag without incurring unacceptable viscous losses. However, their performance

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Zdyrko, Nataliya. "Audit of Compliance of Public Procurement: Theoretical and Practical Aspects." Accounting and Finance, no. 1(91) (2021): 90–100. http://dx.doi.org/10.33146/2307-9878-2021-1(91)-90-100.

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The purpose of the article is to identify the main elements of the public procurement compliance audit and disclose the practical aspects of its implementation. It was determined that the control function is a priority in the management of public procurement in Ukraine among other functions (planning, organization, accounting, analysis, motivation, regulation). The problem of non-compliance of legislative provision of the state audit with international ISSAI standards due to the lack of compliance audit was identified. The main legislative requirements (general and specific) for conducting the

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Tölgyesi, Ádám, Luca Kozma, and Virender K. Sharma. "Determination of Alternaria Toxins in Sunflower Oil by Liquid Chromatography Isotope Dilution Tandem Mass Spectrometry." Molecules 25, no. 7 (2020): 1685. http://dx.doi.org/10.3390/molecules25071685.

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Alternaria toxins have gained attention as a potential health risk and can be classified as emerging mycotoxins. As a result, they are candidates to be regulated by the European Commission. This paper describes a liquid chromatography tandem mass spectrometric (LC-MS/MS) method for analyzing five Alternaria toxins in sunflower oil, which is a rather different type of sample to those matrices investigated in earlier published papers. An optimal sample preparation condition was achieved when samples were dissolved in n-hexane and extracted with methanol/water mixture, followed by sample pre-conc

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