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Journal articles on the topic 'Pre-cancer prognosis'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Luo, Juhua, Michael Hendryx, Lihong Qi, Gloria YF Ho, and Karen L. Margolis. "Pre-existing diabetes and lung cancer prognosis." British Journal of Cancer 115, no. 1 (2016): 76–79. http://dx.doi.org/10.1038/bjc.2016.141.

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Luo, J., M. Hendryx, B. Virnig, et al. "Pre-existing diabetes and breast cancer prognosis among elderly women." British Journal of Cancer 113, no. 5 (2015): 827–32. http://dx.doi.org/10.1038/bjc.2015.249.

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Yamamoto, Manabu, Hiroaki Saito, Chihiro Uejima, et al. "Combined Pre- and Postoperative Lymphocyte Count Accurately Predicts Outcomes of Patients with Colorectal Cancer." Digestive Surgery 36, no. 6 (2018): 487–94. http://dx.doi.org/10.1159/000492340.

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Background: Although preoperative lymphopenia is reportedly a prognostic factor in cancer patients, the association between postoperative lymphopenia and patient prognosis has not been widely studied. Methods: We enrolled 379 patients who underwent surgery for colorectal cancer (CRC) to analyze correlations among pre- and postoperative lymphocyte counts (LCs) and prognosis in patients with CRC. Results: Pre- and postoperative LCs were significantly correlated (r = 0.615, p < 0.0001). Based on results of receiver operating characteristic analysis, patients were subgrouped as preoperative LC

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Battista, Serena, Maria Raffaella Ambrosio, Francesco Limarzi, Graziana Gallo, and Luca Saragoni. "Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer." International Journal of Molecular Sciences 22, no. 13 (2021): 6652. http://dx.doi.org/10.3390/ijms22136652.

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Prognosis of gastric cancer is dramatically improved by early diagnosis. Correa’s cascade correlates the expression of some molecular markers with the progression of preneoplastic lesions toward carcinoma. This article reviews the diagnostic and prognostic values of molecular markers in complete (MUC2) and incomplete (MUC2, MUC5AC, and MUC6) intestinal metaplasia, gastric dysplasia/intra-epithelial neoplasia, and early gastric cancer. In particular, considering preinvasive neoplasia and early gastric cancer, some studies have demonstrated a correlation between molecular alterations and prognos

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Snyder, C. F., K. B. Stein, B. B. Barone, et al. "Does pre-existing diabetes affect prostate cancer prognosis? A systematic review." Prostate Cancer and Prostatic Diseases 13, no. 1 (2009): 58–64. http://dx.doi.org/10.1038/pcan.2009.39.

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Lin, Nan, Oana A. Zeleznik, Julian Avila-Pacheco, et al. "Abstract 3682: Pre-surgical blood metabolites associated with ovarian cancer prognosis." Cancer Research 84, no. 6_Supplement (2024): 3682. http://dx.doi.org/10.1158/1538-7445.am2024-3682.

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Abstract Background: Ovarian cancer has a poor prognosis with a 5-year survival less than 50%, resulting &gt; 14,000 deaths in the US annually and &gt; 150,000 globally. Identifying prognostic biomarkers at time of diagnosis and elucidating the biological dysregulation among those who are more likely to progress after first-line treatment could inform personalized treatment strategies. Thus, we evaluated metabolites and metabolomic profiles in pretreatment blood associated with survival in women with high-grade serous ovarian cancer, the most common and most deadly histologic subtype.

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Kandemir, EG, A. Mayadagli, B. Karagoz, O. Bilgi, O. Turken, and M. Yaylaci. "Prognostic Significance of Thrombocytosis in Node-negative Colon Cancer." Journal of International Medical Research 33, no. 2 (2005): 228–35. http://dx.doi.org/10.1177/147323000503300211.

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Several clinical studies have shown that thrombocytosis is a poor prognostic factor in some types of cancer, but data about the impact of thrombocytosis on prognosis in patients with colon cancer are very limited. We investigated the prevalence and prognostic effect of pre-operative thrombocytosis, defined as a platelet count > 400 × 109/l, retrospectively in patients with node-negative colon cancer. Out of 198 patients, 24 (12.1%) had thrombocytosis, and its presence correlated with tumour depth and lymphatic invasion. Univariate analysis revealed that disease-free survival and overall sur

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López-Cortés, Xaviera A., Felipe Matamala, Bernardo Venegas, and César Rivera. "Machine-Learning Applications in Oral Cancer: A Systematic Review." Applied Sciences 12, no. 11 (2022): 5715. http://dx.doi.org/10.3390/app12115715.

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Over the years, several machine-learning applications have been suggested to assist in various clinical scenarios relevant to oral cancer. We offer a systematic review to identify, assess, and summarize the evidence for reported uses in the areas of oral cancer detection and prevention, prognosis, pre-cancer, treatment, and quality of life. The main algorithms applied in the context of oral cancer applications corresponded to SVM, ANN, and LR, comprising 87.71% of the total published articles in the field. Genomic, histopathological, image, medical/clinical, spectral, and speech data were used

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Tsang, Mazie, Siqi Gan, Melisa L. Wong, Louise Christie Walter, and Alexander K. Smith. "Pre-existing geriatric conditions in older adults with poor prognosis cancers." Journal of Clinical Oncology 39, no. 15_suppl (2021): 12044. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.12044.

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12044 Background: Older adults with poor prognosis cancers are more likely to experience toxicity from cancer-directed therapies. Although geriatric assessment (GA) reduces chemotherapy toxicity by detecting pre-existing conditions, GA can be difficult for oncologists to perform because of limited time and resources. We aim to determine the prevalence of pre-existing geriatric conditions that could be detected if GA were performed during routine oncology care. Methods: We used the Health and Retirement Study (HRS) linked with Medicare (1998-2016) to identify adults age >65 with poor prognos

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Extermann, Martine, Biwei Cao, Anders E. Berglund, et al. "Ovarian cancer: Age, prognosis, and biologic underpinnings." Journal of Clinical Oncology 40, no. 16_suppl (2022): e17555-e17555. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e17555.

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e17555 Background: The prognosis of ovarian cancer worsens markedly with age. Yet few data are available to explain this phenomenon. Two hypotheses can be made. Changes in pharmacokinetics (PK) and treatment tolerance limit the dosing of chemotherapy, and/or changes in tumor and host-tumor biology limit treatment efficacy. Objective:To identify PK, body composition, and biologic changes with age that may impact prognosis. We reported PK findings in a previous abstract (Extermann et al., ASCO 2021) In this abstract we focus on the biologic findings. Methods: We conducted a prospective cohort st

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Nathan, Revathy, and M. Rithani. "Lung Cancer Prognosis Through Standardized Pre-Processing And Multifaceted Data Enhancement: A Deep Learning Approach." SHS Web of Conferences 194 (2024): 01006. http://dx.doi.org/10.1051/shsconf/202419401006.

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With high rates of morbidity and mortality, lung cancer continues to be a major problem for world health. A precise prognosis is essential for clinical judgment and patient care. This study provides a unique deep learning method for enhancing the prognosis of lung cancer through multimodal data enhancement and standardized pre-processing. The proposed methodology begins with the comprehensive pre-processing of diverse patient data sources, including medical images, clinical records, and genomic information. Standardization techniques are applied to ensure data consistency and reliability, redu

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Shigematsu, Hideo, Mutsumi Fujimoto, Yoshie Kobayashi, et al. "Abstract PO3-07-12: Effect of neoadjuvant chemotherapy on peritumoral edema in early stage breast cancer and its prognostic value." Cancer Research 84, no. 9_Supplement (2024): PO3–07–12—PO3–07–12. http://dx.doi.org/10.1158/1538-7445.sabcs23-po3-07-12.

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Abstract Objectives: We aimed to evaluate the effect of neoadjuvant chemotherapy (NAC) on peritumoral edema (PE) and its prognostic value in operable breast cancer. Materials & Methods: This retrospective study included 128 cT1-4N0-3M0 breast cancer patients who underwent contrast-enhanced magnetic resonance imaging (MRI) of the breast before and after anthracycline- and/or taxane-based NAC, followed by curative surgery at our hospital, between 2006 and 2016. T2-weighted MRI revealed PE, and PE before NAC (pre-PE) and PE after NAC (residual PE) were evaluated. The correlation between the p

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SOHDA, MAKOTO, MAKOTO SAKAI, ARISA YAMAGUCHI, et al. "Pre-treatment CRP and Albumin Determines Prognosis for Unresectable Advanced Oesophageal Cancer." In Vivo 36, no. 4 (2022): 1930–36. http://dx.doi.org/10.21873/invivo.12914.

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Jain, Meera, and Anthony B. Miller. "Pre-morbid body size and the prognosis of women with breast cancer." International Journal of Cancer 59, no. 3 (1994): 363–68. http://dx.doi.org/10.1002/ijc.2910590312.

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Rao, T. Uma Maheswara, Venkat Hanuman Phanikumar, and Hemanth Kumar. "Albumin, prealbumin and CRP levels can be used to predict prognosis in gastric cancer." International Surgery Journal 4, no. 3 (2017): 941. http://dx.doi.org/10.18203/2349-2902.isj20170616.

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Background: malnutrition and systemic inflammatory response in cancers result in a shorter survival rate, reduced treatment response and a higher rate of complications associated with therapy. Prealbumin, albumin and CRP Levels has utility as a prognostic indicator of cancer survival in cancer. The objective of this study was to albumin, pre-albumin and CRP levels of the patients who underwent surgery for gastric cancer were prospectively recorded and retrospectively evaluated.Methods: Study was done for period of 1 year in patients underwent surgery for gastric cancer. Details noted from reco

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Saito, Hiroaki, Yusuke Kono, Yuki Murakami, et al. "Prognostic Significance of Pre- and Postoperative Lymphocyte Counts in Patients with Gastric Cancer." Digestive Surgery 36, no. 2 (2018): 137–43. http://dx.doi.org/10.1159/000486581.

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Background: Although preoperative lymphopenia is reportedly a prognostic factor in cancer patients, the association between postoperative lymphopenia and patient prognosis has not been widely studied. Methods: We enrolled 352 patients who underwent surgery for gastric cancer (GC) between January 2005 and April 2013 to analyze correlations among pre- and postoperative lymphocyte counts (LCs) and prognosis in GC patients. Results: Pre- and postoperative (obtained 1 day after surgery) LCs were significantly correlated (r = 0.496, p < 0.0001). Pre- and postoperative LCs of elderly patients were

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Jung, Audrey Y., Xinting Cai, Kathrin Thoene, et al. "Antioxidant supplementation and breast cancer prognosis in postmenopausal women undergoing chemotherapy and radiation therapy." American Journal of Clinical Nutrition 109, no. 1 (2019): 69–78. http://dx.doi.org/10.1093/ajcn/nqy223.

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ABSTRACT Background There is a paucity of information on the prevalence of dietary supplement use in breast cancer survivors. Only a few studies have examined the impact of dietary supplements, particularly antioxidants, on breast cancer prognosis and the results are inconclusive. Objective We examined pre- and postdiagnosis use of supplements in postmenopausal breast cancer survivors in Germany and investigated associations between postdiagnosis use of antioxidants and other supplements, and prognosis (total and breast cancer mortality, and recurrence-free survival) both overall and in women

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Goodgame, Boone W., Farya Phillips, Wenhui Vivian Zhang, and Barbara L. Jones. "Communicating Oncologic Prognosis with Empathy (COPE) Pilot Study." Journal of Clinical Oncology 37, no. 15_suppl (2019): 11613. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.11613.

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11613 Background: Multiple studies show that patients with advanced cancer often believe the goal of treatment is cure. Our interprofessional team designed the Communicating Oncologic Prognosis with Empathy (COPE) guide to enhance communication for patients, families, and the healthcare team. This unique, single-page tool allows treating physicians to estimate prognosis for patients, including likelihood of living 6 mo, 1y, 2y, and 5y, with or without treatment. Methods: Patients with incurable cancer were enrolled at one oncology clinic. Using a pre/post-test design, participants completed th

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Vallboehmer, D., E. Kuhn, J. Brabender, et al. "Survivin expression in esophageal cancer: Association with histomorphological response to neoadjuvant therapy and prognosis." Journal of Clinical Oncology 25, no. 18_suppl (2007): 4536. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4536.

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4536 Background: The poor prognosis associated with locally advanced esophageal cancer prompted an evaluation of combined modality treatments including neoadjuvant radiochemotherapy in combination with surgery. However, it has been well established that only patients with a complete pathological response to neoadjuvant therapy will have a significant survival benefit. Therefore, predictive markers to allow a tailored radiochemotherapy are needed. The aim of this study was to examine the association of the protein expression of survivin, an inhibitor of apoptosis, with histopathologic response

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Mizuno, Keiko, Kengo Tanigawa, Nijiro Nohata, et al. "FAM64A: A Novel Oncogenic Target of Lung Adenocarcinoma Regulated by Both Strands of miR-99a (miR-99a-5p and miR-99a-3p)." Cells 9, no. 9 (2020): 2083. http://dx.doi.org/10.3390/cells9092083.

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Lung adenocarcinoma (LUAD) is the most aggressive cancer and the prognosis of these patients is unfavorable. We revealed that the expression levels of both strands of miR-99a (miR-99a-5p and miR-99a-3p) were significantly suppressed in several cancer tissues. Analyses of large The Cancer Genome Atlas (TCGA) datasets showed that reduced miR-99a-5p or miR-99a-3p expression is associated with worse prognoses in LUAD patients (disease-free survival (DFS): p = 0.1264 and 0.0316; overall survival (OS): p = 0.0176 and 0.0756, respectively). Ectopic expression of these miRNAs attenuated LUAD cell prol

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Feier, Catalin Vladut Ionut, Calin Muntean, Alaviana Monique Faur, et al. "An Exploratory Assessment of Pre-Treatment Inflammatory Profiles in Gastric Cancer Patients." Diseases 12, no. 4 (2024): 78. http://dx.doi.org/10.3390/diseases12040078.

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Gastric cancer ranks as the fifth most common cancer, and the assessment of inflammatory biomarkers in these patients holds significant promise in predicting prognosis. Therefore, data from patients undergoing surgical intervention for gastric cancer over a 7-year period were analyzed. This study was retrospective and involved a preoperative investigation of six inflammatory parameters derived from complete blood counts. Statistical analysis revealed a significant increase in the leucocyte-to-monocyte ratio (LMR) (p = 0.048), along with a significant decrease in the number of lymphocytes and m

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Dr., Sandeep Kumar, Manisha Roy Dr, Nupur Nelson Dr, et al. "Pre-treatment de-ritis ratio as a marker for cervical cancer: a study at regional cancer centre." International Journal of Medical Research and Review 7, no. 3 (2019): 162–69. https://doi.org/10.17511/ijmrr.2019.i03.03.

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Background: The role of AST/ALT ratio in prognostication of cancer cervix is not established in different study settings except for very few where they have highlighted on circulation of higher levels of AST and ALT in the cervical cancer patients. Moreover, there is a biological plausibility explained in one of the studies hence the study was conducted to elicit if the AST/ALT ratio could predict the prognosis of advanced cancer cervix before the initiation of treatment. Methodology: A follow up study was conducted among 122 newly diagnosed locally advanced carcinoma cervix patients in a regi

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Jung, Seung Pil, Soo Youn Bae, Jeong Hyeon Lee, and Joung Won Bae. "Differences in prognosis by p53 expression after neoadjuvant chemotherapy in triple-negative breast cancer." Journal of Global Oncology 5, suppl (2019): 119. http://dx.doi.org/10.1200/jgo.2019.5.suppl.119.

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119 Background: Triple negative breast cancer (TNBC) exhibits a higher rate of early recurrence and more aggressive behavior. Despite unfavorable prognoses, TNBCs are known to be highly reactive to chemotherapy and show higher pathologic complete response rates after neoadjuvant chemotherapy. However, TNBC patients with residual cancer have significantly worse prognoses than patients with non-TNBC associated residual cancer. TP53 mutations are the most common genetic alterations in breast cancer and are highly linked to basal subtype carcinomas. Past studies have investigated if TP53 mutation

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Chen, Yue, Rui Zhang, Xinxin Dong, and Fang Liu. "Evaluation of prognosis of rectal cancer patients with neoadjuvant chemoradiotherapy by clinical TNM stage: Is it suitable?" Journal of Clinical Oncology 38, no. 15_suppl (2020): e16029-e16029. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16029.

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e16029 Background: In the Union for International Cancer Control /American Joint Committee on Cancer TNM classification system, the prognosis of rectal cancer patients with adjuvant treatment are based on pre-radiotherapy clinical TNM stage. However, the value of this classification system is still debated. Here, we find that neoadjuvant pathologic TNM stage may be better than clinical TNM stage in patients with rectal cancer. Furthermore, we propose a novel risk stratification which may be more accurate in the assessment of prognosis of these patients. Methods: Between 2010 and 2015, 316 pati

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Ragusi, Max AA, Gonneke AO Winter-Warnars, Jelle Wesseling, et al. "Prognostic value of breast MRI characteristics before and during neoadjuvant endocrine therapy in patients with ER+/HER2- breast cancer." British Journal of Radiology 94, no. 1123 (2021): 20201125. http://dx.doi.org/10.1259/bjr.20201125.

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Objective: To investigate whether BIRADS MRI characteristics before or during neoadjuvant endocrine therapy (NET) are associated with the preoperative endocrine prognostic index (PEPI) in ER+/HER2- breast cancer patients. Methods: This retrospective observational cohort study included 35 ER+/HER2- patients with 38 tumors (3 bilateral cases) treated with NET. The pre- and midtreatment (after 3 months) MRIs were evaluated by two breast radiologists for BIRADS imaging characteristics, shrinkage pattern, and radiologic response. PEPI was used as end point. PEPI is based on the post-treatment surgi

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Yang, Lei, Kaarina Korhonen, Heta Moustgaard, Karri Silventoinen, and Pekka Martikainen. "Pre-existing depression predicts survival in cardiovascular disease and cancer." Journal of Epidemiology and Community Health 72, no. 7 (2018): 617–22. http://dx.doi.org/10.1136/jech-2017-210206.

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BackgroundPrevious studies have found depression to be negatively associated with the prognosis of both cardiovascular disease (CVD) and cancer, but this may partly reflect reverse causality. We limited the possibility of reverse causality by measuring depression before the first diagnosis of CVD or cancer.MethodsWe used an 11% longitudinal random sample of the Finnish population aged 25 years or older who are residents of Finland for at least 1 year between 1987 and 2007, with an 80% oversample of those who died during this period. Those who had their first incidence of coronary heart disease

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van Dalen, A. "Pre-Operative Tumour Marker Levels in Patients with Breast Cancer and Their Prognosis." Tumor Biology 11, no. 4 (1990): 189–95. http://dx.doi.org/10.1159/000217654.

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Schwameis, Richard, Gerda Hofstetter, Stefanie Aust, et al. "The role of gamma-glutamyltransferase in malignant transformation and prognosis of ovarian cancer." Journal of Clinical Oncology 31, no. 15_suppl (2013): e16524-e16524. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e16524.

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e16524 Background: Gamma-glutamyltransferase (GGT) – a membrane bound enzyme crucially involved in the cell’s detoxification pathway and apoptotic balance – is involved in tumor development, progression and chemotherapy resistance. Elevated GGT serum levels are associated with increased cancer risk in women and worse prognosis in gynecologic cancers. The present study investigated the prognostic role of GGT in ovarian cancer patients. Methods: In this multi-center study, pre-therapeutic GGT levels were ascertained in 634 consecutive patients with epithelial ovarian cancer (EOC, n = 567) and bo

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Jang, Wooyoung, Jad F. Zeitouni, Daniel K. Nguyen, et al. "The Effectiveness of Inflammatory Indexes in Assessing Oropharyngeal Cancer Prognosis." Surgeries 5, no. 2 (2024): 377–90. http://dx.doi.org/10.3390/surgeries5020031.

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Background: Inflammation has long been a key tenet in the diagnosis and management of malignancies, likely contributing to cancer incidence, staging, and progression. Systemic inflammation, in particular, is often elevated prior to and during cancer development. Systemic inflammation in the context of cancer diagnosis and monitoring is measured by various inflammatory indexes such as the systemic inflammatory response index (SIRI), plasma-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and neutrophil-to-lymphocyte ratio (NLR). We set out to determine the relationship betwe

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Tsukagoshi, Mariko, Kenichiro Araki, Norio Kubo, et al. "Impact of Preoperative Weight Loss on Prognosis in Patients with Pancreatic Cancer." Biomedicines 13, no. 7 (2025): 1703. https://doi.org/10.3390/biomedicines13071703.

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Background/Objectives: This study aimed to investigate the impact of preoperative weight loss on long-term postoperative survival and the significance of preoperative nutrition on perioperative weight change in patients with pancreatic cancer. Methods: Overall, 125 patients who underwent radical resection for invasive pancreatic ductal carcinoma were retrospectively analyzed. The preoperative weight loss rate (pre-%WL) from the initial visit to immediately before surgery was calculated. Patients were classified by pre-%WL into the weight-loss (≥6% loss) and weight-maintenance (<6% loss) gro

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Wu, Yi-Feng, Sung-Chao Chu, Bee-Song Chang, Yi-Tso Cheng, and Tso-Fu Wang. "Hematologic Markers as Prognostic Factors in Nonmetastatic Esophageal Cancer Patients under Concurrent Chemoradiotherapy." BioMed Research International 2019 (January 29, 2019): 1–11. http://dx.doi.org/10.1155/2019/1263050.

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Nonmetastatic esophageal cancer can demonstrate a high local recurrence rate even under the standard treatment. We evaluated platelet counts before and after concurrent chemoradiotherapy (CCRT), neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio for predicting esophageal cancer prognosis under CCRT. Newly diagnosed patients with esophageal cancer (stages IA–IIIC) who underwent CCRT during January 2013–December 2017 were enrolled. The data were collected retrospectively. Overall survival (OS), time to progressive disease (TPD), and time to metastasis (TM) were recorded for indicat

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Abdalwahid, Shadan Mohammed Jihad, Sami Ismael, and Shahab Wahhab Kareem. "Pre-Cancer Diagnosis via TP53 Gene Mutations Applied Ensemble Algorithms." Technium BioChemMed 2, no. 4 (2021): 9–16. http://dx.doi.org/10.47577/biochemmed.v2i4.4654.

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According to current study, individuals with cancer who have a gene mutation have a bad prognosis. Young women with breast cancer had a poorer prognosis than older women, although it is unknown if the p53 gene mutation contributed to this. Due in part to the devastation of cancer, the appropriate technology may help cancer sufferers in regaining their lives. Researchers seek for mutations in cancer-causing gene sequences in order to identify the precancerous stage. While genetic testing may be used to forecast some kinds of cancer, there is presently no effective technique for identifying all

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Li, Yinglu, Zhiming Li, and Wei-Guo Zhu. "Molecular Mechanisms of Epigenetic Regulators as Activatable Targets in Cancer Theranostics." Current Medicinal Chemistry 26, no. 8 (2019): 1328–50. http://dx.doi.org/10.2174/0929867324666170921101947.

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Epigenetics is defined as somatically inheritable changes that are not accompanied by alterations in DNA sequence. Epigenetics encompasses DNA methylation, covalent histone modifications, non-coding RNA as well as nucleosome remodeling. Notably, abnormal epigenetic changes play a critical role in cancer development including malignant transformation, metastasis, prognosis, drug resistance and tumor recurrence, which can provide effective targets for cancer prognosis, diagnosis and therapy. Understanding these changes provide effective means for cancer diagnosis and druggable targets for better

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Reibel, Jesper. "Prognosis of Oral Pre-malignant Lesions: Significance of Clinical, Histopathological, and Molecular Biological Characteristics." Critical Reviews in Oral Biology & Medicine 14, no. 1 (2003): 47–62. http://dx.doi.org/10.1177/154411130301400105.

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The concept of a two-step process of cancer development in the oral mucosa, i.e., the initial presence of a precursor subsequently developing into cancer, is well-established. Oral leukoplakia is the best-known precursor lesion. The evidence that oral leukoplakias are pre-malignant is mainly derived from follow-up studies showing that between < 1 and 18% of oral pre-malignant lesions will develop into oral cancer; it has been shown that certain clinical sub-types of leukoplakia are at a higher risk for malignant transformation than others. The presence of epithelial dysplasia may be even mo

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Chen, Wei-Chung, Chun-Chieh Wu, Yi-Hsun Chen, et al. "Change in PD-L1 and CD8 Expression after Chemoradiotherapy for Esophageal Squamous Cell Carcinoma." Biomedicines 10, no. 8 (2022): 1888. http://dx.doi.org/10.3390/biomedicines10081888.

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Esophageal cancer has a dismal prognosis with a five-year survival rate below 20%. Recently, immunotherapy has become a new standard of care for this cancer; therefore, we aimed to examine the programmed death ligand 1 (PD-L1) expression in esophageal squamous cell carcinoma (ESCC) tissues before and after concurrent chemoradiation therapy (CCRT). In total, 64 patients with pre-CCRT ESCC specimens were examined for PD-L1 expression, with twenty-three of them having a partial response (N = 23) or stable disease (N = 1) after CCRT while post-CCRT tissue specimens were collected. All of them were

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Manikam, Nurul Ratna, Yosua Y. Kristian, Luana Lidwina, Ayu Diandra Sari, and Diana Sunardi. "Prediction of Post-operative Survival of Colorectal Cancer Patient By Using the Prognostic Nutritional Index: An Evidence-Based Case Report." World Nutrition Journal 2, no. 2 (2019): 25. http://dx.doi.org/10.25220/wnj.v02.i2.0005.

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Background: Colorectal cancer patients may be treated with several modalities and one of them is surgical treatment. Surgery in cancer patients is risky procedure and may not always resulted in prolonged survival. Therefore, before receiving any recommended treatment, the patient’s prognosis has to be assessed and defined properly. Several methods are available to assess the prognosis of cancer patients; one of them is the prognostic nutritional index (PNI).Objective: This study aimed to predict the survival of a colorectal cancer patient post-operatively by calculating the pre-operative PNI s

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Saito, Shigeo, Chia-Chen Ku, Kenly Wuputra, et al. "Biomarkers of Cancer Stem Cells for Experimental Research and Clinical Application." Journal of Personalized Medicine 12, no. 5 (2022): 715. http://dx.doi.org/10.3390/jpm12050715.

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The use of biomarkers in cancer diagnosis, therapy, and prognosis has been highly effective over several decades. Studies of biomarkers in cancer patients pre- and post-treatment and during cancer progression have helped identify cancer stem cells (CSCs) and their related microenvironments. These analyses are critical for the therapeutic application of drugs and the efficient targeting and prevention of cancer progression, as well as the investigation of the mechanism of the cancer development. Biomarkers that characterize CSCs have thus been identified and correlated to diagnosis, therapy, an

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Wu, Qijing, Qiong Huang, Mengting Sun, et al. "Unraveling metabolism heterogeneity in colorectal cancer and its implications in pan-cancer cohort." Journal of Clinical Oncology 38, no. 15_suppl (2020): e16016-e16016. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16016.

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e16016 Background: Colorectal cancer (CRC) molecular subtype has been emphasized and links to biological and clinical behavior. However, comprehensive metabolism of CRC has not been characterized. Subtype-specific metabolic differences and immunometabolism phenotypes remain unclear. Therefore, this study performed metabolism clustering and explore its relation with immune phenotypes as well as prognosis predictive value. Methods: Transcriptome of TCGA CRC cohort was utilized to generate 113 KEGG metabolism pathway scores via GSVA algorithm. Consensus clustering were used to identify metabolism

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Kazarian, Anna, Oleg Blyuss, Gergana Metodieva, et al. "Testing breast cancer serum biomarkers for early detection and prognosis in pre-diagnosis samples." British Journal of Cancer 116, no. 4 (2017): 501–8. http://dx.doi.org/10.1038/bjc.2016.433.

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Abdallah, Nadia. "Independence of liver, renal and blood physiology in prognosis of pre-menopausal breast cancer." Bulletin of Faculty of Science, Zagazig University 2022, no. 3 (2022): 91–95. http://dx.doi.org/10.21608/bfszu.2022.144859.1150.

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Puglisi, F., C. Di Loreto, M. Bazzocchi, G. Anania, and C. A. Beltrami. "116 O - Large core breast biopsy: a pre-operative tool in breast cancer prognosis." European Journal of Cancer 32 (January 1996): S23. http://dx.doi.org/10.1016/0959-8049(96)84873-8.

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Schmidt, Viktoria, Julia Kaiser, Julia Treml, and Anette Kersting. "Factors associated with pre-loss grief and preparedness in relatives of people with cancer during the COVID-19 pandemic: A cross-sectional study." PLOS ONE 17, no. 11 (2022): e0278271. http://dx.doi.org/10.1371/journal.pone.0278271.

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Objectives Before the loss of a loved one to cancer, relatives have time to adapt to the impending death. However, due to the current COVID-19 pandemic, adjustment to an imminent death may be more difficult. This study investigates factors related to pre-loss grief and preparedness during the COVID-19 pandemic and their relationship with COVID-19 related fears. Methods Data of 299 participants from a cross-sectional study was used. Participants were included if they were relatives of people with cancer, spoke German and were at least 18 years. Multivariate linear regression analyses were condu

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Fröhlich, Anaïs, JoEllen Welter, Isabell Witzel, Julia Voppichler, and Mathias K. Fehr. "Does an Autoimmune Disorder Following Ovarian Cancer Diagnosis Affect Prognosis?" Current Oncology 31, no. 8 (2024): 4613–23. http://dx.doi.org/10.3390/curroncol31080344.

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We investigated whether developing an autoimmune disorder (AID) following a high-grade epithelial ovarian cancer diagnosis improves overall survival. This retrospective study included data from women treated for high-grade serous, endometrioid, or transitional cell ovarian, fallopian tube, or peritoneal cancer FIGO stage III or IV at a Swiss cantonal gynecological cancer center (2008–2023). We used Kaplan–Meier estimates and the Cox proportional hazards model using time-varying covariates for the survival function estimation. In all, 9 of 128 patients developed an AID following a cancer diagno

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Ma, Yifei, Ping Lu, Xinjun Liang, and Shaozhong Wei. "Prognostic role of apolipoprotein and lactate dehydrogenase levels in resectable colorectal cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): e15541-e15541. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e15541.

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e15541 Background: Apolipoprotein b (apob), apolipoprotein a1 (apoa1), and lactate dehydrogenase (LDH) levels are circulating biomarkers that relate to tumor inflammation. This study aimed to evaluate the prognostic role of apob/apoa1 and LDH in resectable colorectal cancer (CRC). Methods: 513 patients of colorectal cancer (CRC) from Hubei cancer hospital were included finally, and we collected the pre-operative laboratory results within a week before surgery. We combined the two indicators and divided them into three groups (group 1: apob/apoa1-LDH low; group 2: apob/apoa1 or LDH high; group

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Kosaka, Hisashi, Masaki Ueno, Koji Komeda, et al. "The Impact of a Preoperative Staging System on Accurate Prediction of Prognosis in Intrahepatic Cholangiocarcinoma." Cancers 14, no. 5 (2022): 1107. http://dx.doi.org/10.3390/cancers14051107.

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Background: Non-invasive biomarkers detected preoperatively are still inadequate for treatment decision making for patients with intrahepatic cholangiocarcinoma (ICC). In this study, we analyzed preoperative findings to establish a novel preoperative staging system (PRE-Stage) for patients with ICC. Methods: The clinical data of 227 consecutive patients with histologically confirmed ICC following hepatectomy at five university hospitals were analyzed. Results: Cox proportional hazards regression analysis of survival revealed that a CRP–albumin–lymphocyte index < 3, central tumor location, a

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Gupta, Shankar Kumar, Vinod Kumar, Afzal Anees, and Arjun Goel. "The study of prognostic significance of CA 15-3 in breast cancer." International Surgery Journal 5, no. 2 (2018): 580. http://dx.doi.org/10.18203/2349-2902.isj20180356.

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Background: Cancer Antigen 15-3 (CA 15-3) is a tumour-associated antigen used as serum marker for breast cancer surveillance in patients and for monitoring the response to treatment. Aim of this study was to prospectively evaluate CA 15-3 as a prognostic factor in early detection of breast cancer relapse, recurrence and early detection of distant metastasis as well as to analyse the statistical correlation between CA 15-3 levels and clinical-pathological parameters including tumour size, lymph node, histological type, grading, hormonal receptors.Methods: Sera of 85 women with breast carcinoma

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Abdulkareem Ibrahim,, Aisha, and Sardar Nori Ahmed. "Study of Serum Adiponectin, Leptin, and Galectin-3 in Breast Cancer." Diyala Journal of Medicine 24, no. 1 (2023): 185–96. http://dx.doi.org/10.26505/djm.v24i1.983.

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Background: Breast cancer is the most common cancer that threatens the lives of women all over the world. Adipocytokines (adiponectin, leptin), and the β-galactoside-binding proteins (galectin-3) are new suggested parameters for the diagnosis and prognosis of breast cancer. Objective: To find relationship between serum adiponectin, leptin, and galectin-3 and breast cancer diagnosis and prognosis factors. Patients and Methods: A case-control study was done between (August 2021 to June 2022). Totally collected 111 female blood samples from patients that diagnosed with a breast cancer and healthy

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Abdulkareem Ibrahim, Aisha, and Sardar Nori Ahmed. "Study of Serum Adiponectin, Leptin, and Galectin-3 in Breast Cancer." Diyala Journal of Medicine 24, no. 1 (2023): 185–96. http://dx.doi.org/10.26505/djm.24016910908.

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Background: Breast cancer is the most common cancer that threatens the lives of women all over the world. Adipocytokines (adiponectin, leptin), and the β-galactoside-binding proteins (galectin-3) are new suggested parameters for the diagnosis and prognosis of breast cancer. Objective: To find relationship between serum adiponectin, leptin, and galectin-3 and breast cancer diagnosis and prognosis factors. Patients and Methods: A case-control study was done between (August 2021 to June 2022). Totally collected 111 female blood samples from patients that diagnosed with a breast cancer and healthy

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He, Yihong, Changhao Huang, Kaimei Cai, et al. "PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance." Acta Biochimica et Biophysica Sinica 53, no. 7 (2021): 893–902. http://dx.doi.org/10.1093/abbs/gmab059.

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Abstract Pre-mRNA processing factor 19 (PRPF19) is a multifaceted protein and participates in DNA damage response and pre-mRNA processing. The role of PRPF19 in cancer is unclear. Here, we report that the expression of PRPF19 in human tongue cancer is associated with unfavorable prognosis. Overexpression of PRPF19 promotes while knockdown of PRPF19 inhibits tongue cancer cell migration, proliferation, and tumor growth. Overexpression of PRPF19 increases the resistance of tongue cancer cells to radiation and cisplatin treatment. Furthermore, PRPF19 regulates the expression of solute carrier fam

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Marcuzzi, Elisabetta, Roberta Angioni, Barbara Molon, and Bianca Calì. "Chemokines and Chemokine Receptors: Orchestrating Tumor Metastasization." International Journal of Molecular Sciences 20, no. 1 (2018): 96. http://dx.doi.org/10.3390/ijms20010096.

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Metastasis still represents the primary cause of cancer morbidity and mortality worldwide. Chemokine signalling contributes to the overall process of cancer growth and metastasis, and their expression in both primary tumors and metastatic lesions correlate with prognosis. Chemokines promote tumor metastasization by directly supporting cancer cell survival and invasion, angiogenesis, and by indirectly shaping the pre-metastatic niches and antitumor immunity. Here, we will focus on the relevant chemokine/chemokine receptor axes that have been described to drive the metastatic process. We elabora

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