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Journal articles on the topic 'Pre-implantation development'

Author: Grafiati

Published: 24 June 2021

Last updated: 29 July 2025

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1

Niakan, K. K., J. Han, R. A. Pedersen, C. Simon, and R. A. R. Pera. "Human pre-implantation embryo development." Development 139, no. 5 (2012): 829–41. http://dx.doi.org/10.1242/dev.060426.

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2

Sudheer, S., and J. Adjaye. "Functional genomics of human pre-implantation development." Briefings in Functional Genomics and Proteomics 6, no. 2 (2007): 120–32. http://dx.doi.org/10.1093/bfgp/elm012.

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3

Zhang, Pu, Marco Zucchelli, Sara Bruce, et al. "Transcriptome Profiling of Human Pre-Implantation Development." PLoS ONE 4, no. 11 (2009): e7844. http://dx.doi.org/10.1371/journal.pone.0007844.

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4

Ko, Minoru S. H. "Embryogenomics of pre-implantation mammalian development: current status." Reproduction, Fertility and Development 16, no. 2 (2004): 79. http://dx.doi.org/10.1071/rd03080.

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Pre-implantation development is marked by many critical molecular events, including the maternal to zygotic transition and the first differentiation of cells. Understanding such events is important, for both basic reproductive biology and practical applications, including regenerative medicine and livestock production. Scarcity of materials has hampered the progress of the field, but systematic genomics approaches are beginning to be applied to the study of pre-implantation development, resulting in unprecedented amounts of data about the pre-implantation process. The first step in embryogenom

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5

Liu, Weimin, and William S. B. Yeung. "LET-7 REGULATES PRE-IMPLANTATION MOUSE EMBRYO DEVELOPMENT." Fertility and Sterility 116, no. 3 (2021): e279. http://dx.doi.org/10.1016/j.fertnstert.2021.07.748.

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6

Maganha, Juliana, Evelise de Souza Rocha, Marcos Antônio Fernandes Brandão, Vera Maria Peters, and Martha de Oliveira Guerra. "Embryo development alteration in rats treated with lapachol." Brazilian Archives of Biology and Technology 49, no. 6 (2006): 927–34. http://dx.doi.org/10.1590/s1516-89132006000700010.

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Lapachol, a naphthoquinone extracted from plants of the genus Tabebuia (family Bignoneaceae), showed multiple therapeutic activities. Pregnant Wistar rats were treated with Lapachol from the 1st to the 4th (pre-implantation period) and from 5th to 7th (implantation period) post insemination day (PID). Mothers were sacrificed on the 5th or on the15th PID. Number of corpora lutea, preimplantation embryo, blastocysts, live and dead fetuses and resorptions were counted. There were no signs of maternal toxicity. The number and the morphology of embryos, during oviduct development (pre-implantation

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7

Justin, R. Chimka, and Jiang Leiying. "A note on interaction and pre-implantation development stages." Journal of Cell and Animal Biology 8, no. 6 (2014): 110–13. http://dx.doi.org/10.5897/jcab2014.0416.

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8

Wu, Xiaoli, Sumit Sandhu, Nehal Patel, Barbara Triggs-Raine, and Hao Ding. "EMG1 is essential for mouse pre-implantation embryo development." BMC Developmental Biology 10, no. 1 (2010): 99. http://dx.doi.org/10.1186/1471-213x-10-99.

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9

Herrick, J., A. Greene, W. Schoolcraft, and R. Krisher. "95 ROLE OF POLYAMINES IN BOVINE PRE-IMPLANTATION DEVELOPMENT." Reproduction, Fertility and Development 28, no. 2 (2016): 177. http://dx.doi.org/10.1071/rdv28n2ab95.

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Polyamines are involved in trophectoderm attachment and outgrowth, but little is known about their role in earlier stages of development. The objective of this study was to evaluate the effects of an inhibitor of polyamine synthesis (difluoromethylornithine, DFMO) on development (blastocyst formation and hatching) and cell allocation to the trophectoderm (TE, CDX2-positive) and inner cell mass (ICM, SOX2-positive) in the bovine embryo. Cumulus-oocyte complexes (COCs) were recovered from slaughterhouse ovaries and matured for 24 h in a defined maturation medium (5.0 mM glucose, 0.6 mM cysteine,

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Jiang, Zongliang, Jiangwen Sun, Hong Dong, et al. "Transcriptional profiles of bovine in vivo pre-implantation development." BMC Genomics 15, no. 1 (2014): 756. http://dx.doi.org/10.1186/1471-2164-15-756.

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Krawchuk, Dayana, and Yojiro Yamanaka. "Understanding inter-strain differences in pre-implantation mouse development." Developmental Biology 356, no. 1 (2011): 204–5. http://dx.doi.org/10.1016/j.ydbio.2011.05.295.

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12

Hupalowska, Anna, Agnieszka Jedrusik, Meng Zhu, Mark T. Bedford, David M. Glover, and Magdalena Zernicka-Goetz. "CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development." Cell 175, no. 7 (2018): 1902–16. http://dx.doi.org/10.1016/j.cell.2018.11.027.

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13

Chin, P. Y., J. G. Thompson, and S. A. Robertson. "Programming embryo development with a pre-implantation inflammatory insult." Journal of Reproductive Immunology 86, no. 1 (2010): 39. http://dx.doi.org/10.1016/j.jri.2010.06.075.

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14

Morgani, Sophie M., and Joshua M. Brickman. "LIF supports primitive endoderm expansion during pre-implantation development." Development 142, no. 20 (2015): 3488–99. http://dx.doi.org/10.1242/dev.125021.

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15

Esmaeilzadeh, Khadijeh, Hamid Gourabi, Masoud Sheidai, Mostafa Fakhri, and Masood Bazrgar. "Taxol Improves Pre-Implantation Development Potential of Mouse Embryos." Gynecologic and Obstetric Investigation 85, no. 1 (2019): 94–99. http://dx.doi.org/10.1159/000502820.

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16

Strnad, Petr, Stefan Gunther, Judith Reichmann, et al. "Inverted light-sheet microscope for imaging mouse pre-implantation development." Nature Methods 13, no. 2 (2015): 139–42. http://dx.doi.org/10.1038/nmeth.3690.

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17

Habibi, Razieh, Sayyed Morteza Hosseini, Faezeh Ghazvini Zadegan, et al. "Functional characterization of NANOG in goat pre-implantation embryonic development." Theriogenology 120 (October 2018): 33–39. http://dx.doi.org/10.1016/j.theriogenology.2018.07.023.

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18

Rankin, Tracy, Selma Soyal, and Jurrien Dean. "The mouse zona pellucida: folliculogenesis, fertility and pre-implantation development." Molecular and Cellular Endocrinology 163, no. 1-2 (2000): 21–25. http://dx.doi.org/10.1016/s0303-7207(99)00236-1.

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19

Tachibana, Masahito, Lisa Clepper, Michelle Sparman, Cathy Ramsey, and Shoukhrat Mitalipov. "The Role of NANOG During Primate Pre-Implantation Embryo Development." Biology of Reproduction 81, Suppl_1 (2009): 248. http://dx.doi.org/10.1093/biolreprod/81.s1.248.

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20

Moley, K. H., W. K. Vaughn, A. H. DeCherney, and M. P. Diamond. "Effect of diabetes mellitus on mouse pre-implantation embryo development." Reproduction 93, no. 2 (1991): 325–32. http://dx.doi.org/10.1530/jrf.0.0930325.

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21

Gutiérrez-Adán, A., M. Perez-Crespo, R. Fernandez-Gonzalez, et al. "Developmental Consequences of Sexual Dimorphism During Pre-implantation Embryonic Development." Reproduction in Domestic Animals 41, s2 (2006): 54–62. http://dx.doi.org/10.1111/j.1439-0531.2006.00769.x.

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22

Gao, Yawei, Xiaoyu Liu, Bin Tang, et al. "Protein Expression Landscape of Mouse Embryos during Pre-implantation Development." Cell Reports 21, no. 13 (2017): 3957–69. http://dx.doi.org/10.1016/j.celrep.2017.11.111.

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23

Wu, Qiuyang, Zixu Zhou, Zhangming Yan, et al. "A temporal extracellular transcriptome atlas of human pre-implantation development." Cell Genomics 4, no. 1 (2024): 100464. http://dx.doi.org/10.1016/j.xgen.2023.100464.

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24

Smirnov, A. А. "Oxygen in the preimplantation development of mammals: concentration in the oviduct/uterus, in vitro cultivation." Krolikovodstvo i zverovodstvo, no. 1 (2025): 44–60. https://doi.org/10.52178/00234885_2025_1_44.

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This review present two aspects regarding the oxygen regime in the development of the pre-implantation embryo: measurement of oxygen concentration in the genital tract (oviduct/uterus) of females of various mammalian species, taking into account the estrous cycle of the animal; development and optimization of the conditions for the development of the embryo in vitro, taking into account the concentration of oxygen in the culture medium. It has been shown that for the twelve mammalian species presented in the review, the value of oxygen concentration in the oviduct/uterus (regardless of the pha

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25

Li, Shuai, and Wipawee Winuthayanon. "Oviduct: roles in fertilization and early embryo development." Journal of Endocrinology 232, no. 1 (2017): R1—R26. http://dx.doi.org/10.1530/joe-16-0302.

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Animal oviducts and human Fallopian tubes are a part of the female reproductive tract that hosts fertilization and pre-implantation development of the embryo. With an increasing understanding of roles of the oviduct at the cellular and molecular levels, current research signifies the importance of the oviduct on naturally conceived fertilization and pre-implantation embryo development. This review highlights the physiological conditions within the oviduct during fertilization, environmental regulation, oviductal fluid composition and its role in protecting embryos and supplying nutrients. Fina

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26

Petropoulos, S., S. P. Panula, J. P. Schell, and F. Lanner. "Single-cell RNA sequencing: revealing human pre-implantation development, pluripotency and germline development." Journal of Internal Medicine 280, no. 3 (2016): 252–64. http://dx.doi.org/10.1111/joim.12493.

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27

Nishii, Kiyomasa, Yasushi Kobayashi, and Yosaburo Shibata. "Absence of connexin43 and connexin45 does not disturb pre- and peri-implantation development." Zygote 24, no. 3 (2015): 457–64. http://dx.doi.org/10.1017/s0967199415000386.

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SummaryGap junctional intercellular communication is assumed to play an important role during pre- and peri-implantation development. In this study, we eliminated connexin43 (Cx43) and connexin45 (Cx45), major gap junctional proteins in the pre- and peri-implantation embryo. We generated Cx43−/−Cx45−/− embryos by Cx43+/−Cx45+/− intercrossing, because mice deficient in Cx43 (Cx43−/−) exhibit perinatal lethality and those deficient in Cx45 (Cx45−/−) exhibit early embryonic lethality. Wild-type, Cx43−/−, Cx45−/−, and Cx43−/−Cx45−/− blastocysts all showed similar outgrowths in in vitro culture. Mo

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28

Ishchuk, Mariia A., Evgeniia M. Komarova, Elena A. Lesik, et al. "Morphokinetic characteristics of preimplantation development of human donor embryos." Journal of obstetrics and women's diseases 73, no. 6 (2025): 67–78. https://doi.org/10.17816/jowd635008.

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Background: The introduction of time-lapse incubators into assisted reproductive technology practices provides a detailed examination of human pre-implantation embryo development. The continuous time-lapse filming technology is used to determine prognostic markers of embryo viability and implantation potential based on morphokinetic parameters. At present, the main time intervals for morphokinetic events during the pre-implantation phase of human embryo development have been documented primarily in embryos from infertile patients, with limited data available concerning the development of donor

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29

Affaf Yousaf, Muhammad Umair Adeel, Nida Anjum Ghouri, et al. "EFFECT OF COCHLEAR IMPLANTATION IN PRE-LINGUAL ADULTS ON SPEECH DEVELOPMENT." Insights-Journal of Health and Rehabilitation 3, no. 2 (Health & Rehab) (2025): 480–86. https://doi.org/10.71000/v6gyyc30.

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Background: Cochlear implants (CIs) have emerged as a transformative intervention for individuals with severe-to-profound sensorineural hearing loss. While extensive research has supported their effectiveness in post lingually deaf individuals, outcomes in prelingually deaf adults remain less explored. This population presents unique auditory and neurological challenges due to a lack of early sound exposure, which may affect speech and language development. Understanding the extent of benefits in this group is vital for evidence-based clinical decisions. Objective: To evaluate the impact of co

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30

Affaf Yousaf, Muhammad Umair Adeel, Nida Anjum Ghouri, et al. "EFFECT OF COCHLEAR IMPLANTATION IN PRE-LINGUAL ADULTS ON SPEECH DEVELOPMENT." Insights-Journal of Health and Rehabilitation 3, no. 2 (Health & Allied) (2025): 494–500. https://doi.org/10.71000/wy9a8b22.

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Background: Cochlear implants (CIs) have emerged as a transformative intervention for individuals with severe-to-profound sensorineural hearing loss. While extensive research has supported their effectiveness in post lingually deaf individuals, outcomes in prelingually deaf adults remain less explored. This population presents unique auditory and neurological challenges due to a lack of early sound exposure, which may affect speech and language development. Understanding the extent of benefits in this group is vital for evidence-based clinical decisions. Objective: To evaluate the impact of co

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31

Fu, Bo, Hong Ma, and Di Liu. "Endogenous Retroviruses Function as Gene Expression Regulatory Elements During Mammalian Pre-implantation Embryo Development." International Journal of Molecular Sciences 20, no. 3 (2019): 790. http://dx.doi.org/10.3390/ijms20030790.

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Pre-implantation embryo development encompasses several key developmental events, especially the activation of zygotic genome activation (ZGA)-related genes. Endogenous retroviruses (ERVs), which are regarded as “deleterious genomic parasites”, were previously considered to be “junk DNA”. However, it is now known that ERVs, with limited conservatism across species, mediate conserved developmental processes (e.g., ZGA). Transcriptional activation of ERVs occurs during the transition from maternal control to zygotic genome control, signifying ZGA. ERVs are versatile participants in rewiring gene

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32

Navarro, M., C. Bluguermann, M. Von Meyeren, V. Bariani, C. Osycka, and A. Mutto. "2 Role of histone H3 lysine 9 trimethylation during bovine pre-implantation embryonic development." Reproduction, Fertility and Development 31, no. 1 (2019): 126. http://dx.doi.org/10.1071/rdv31n1ab2.

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Histones play an important role in DNA’s compaction and organisation into the cellular nucleus. Depending on which histone modification occurs, chromatin can take a conformation of heterochromatin or euchromatin, which are associated with gene repression or expression, respectively. Histone H3 lysine 9 (H3K9) trimethylation (H3K9me3) is associated with gene silencing. At least 3 methyltransferases are able to change the methylation status of H3K9: SUV39H1, SUV39H2, and SETDB1. In several mammalian species, modulation of H3K9 methylation status has been demonstrated to be necessary to achieve a

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33

Gusella, Anna, Guido Martignoni, and Cinzia Giacometti. "Behind the Curtain of Abnormal Placentation in Pre-Eclampsia: From Molecular Mechanisms to Histological Hallmarks." International Journal of Molecular Sciences 25, no. 14 (2024): 7886. http://dx.doi.org/10.3390/ijms25147886.

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Successful human pregnancy needs several highly controlled steps to guarantee an oocyte’s fertilization, the embryo’s pre-implantation development, and its subsequent implantation into the uterine wall. The subsequent placenta development ensures adequate fetal nutrition and oxygenation, with the trophoblast being the first cell lineage to differentiate during this process. The placenta sustains the growth of the fetus by providing it with oxygen and nutrients and removing waste products. It is not surprising that issues with the early development of the placenta can lead to common pregnancy d

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34

Artus, Jérôme, Isabelle Hue, and Hervé Acloque. "Preimplantation development in ungulates: a ‘ménage à quatre’ scenario." Reproduction 159, no. 3 (2020): R151—R172. http://dx.doi.org/10.1530/rep-19-0348.

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In ungulates, early embryonic development differs dramatically from that of mice and humans and is characterized by an extended period of pre- and peri-implantation development in utero. After hatching from the zona pellucida, the ungulate blastocyst will stay free in the uterus for many days before implanting within the uterine wall. During this protracted peri-implantation period, an intimate dialog between the embryo and the uterus is established through a complex series of paracrine signals. The blastocyst elongates, leading to extreme growth of extra-embryonic tissues, and at the same tim

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Yang, Luhan, Claudia Baumann, Rabindranath De La Fuente, and Maria M. Viveiros. "Bisphenol Exposure Disrupts Cytoskeletal Organization and Development of Pre-Implantation Embryos." Cells 11, no. 20 (2022): 3233. http://dx.doi.org/10.3390/cells11203233.

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The endocrine disrupting activity of bisphenol compounds is well documented, but less is known regarding their impact on cell division and early embryo formation. Here, we tested the effects of acute in vitro exposure to bisphenol A (BPA) and its common substitute, bisphenol F (BPF), during critical stages of mouse pre-implantation embryo development, including the first mitotic division, cell polarization, as well as morula and blastocyst formation. Timing of initial cleavage was determined by live-cell imaging, while subsequent divisions, cytoskeletal organization and lineage marker labeling

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36

Anifandis, G., C. I. Messini, K. Dafopoulos, and I. E. Messinis. "Genes and Conditions Controlling Mammalian Pre- and Post-implantation Embryo Development." Current Genomics 16, no. 1 (2015): 32–46. http://dx.doi.org/10.2174/1389202916666141224205025.

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37

Komatsu, Kouji, and Toshihiko Fujimori. "Multiple phases in regulation of Nanog expression during pre-implantation development." Development, Growth & Differentiation 57, no. 9 (2015): 648–56. http://dx.doi.org/10.1111/dgd.12244.

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38

Scenna, F. N., J. L. Edwards, and F. N. Schrick. "139PROSTAGLANDIN F2± COMPROMISES DEVELOPMENT OF PRE-IMPLANTATION BOVINE EMBRYOS DURING COMPACTION." Reproduction, Fertility and Development 16, no. 2 (2004): 191. http://dx.doi.org/10.1071/rdv16n1ab139.

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Several studies have implicated prostaglandin F2α (PGF) as a major embryotoxic factor during early embryonic development in cattle. Elevated uterine concentrations of PGF were negatively associated with embryo development, quality and pregnancy rates (Schrick FN et al. 1993 Biol. Reprod. 49, 617–621; Hockett ME et al. 1998 J. Anim. Sci. 76 (Suppl 1), 241 abst; Seals RC et al. 1998 Prostaglandins 56, 377–389). Moreover, addition of PGF to culture medium decreased hatching rates of compacted morulae (Scenna FN et al. 2002 Theriogenology 53, 512 abst) and decreased development of pre-compacted (1

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39

Yamagata, K. "Capturing Epigenetic Dynamics During Pre-implantation Development Using Live Cell Imaging." Journal of Biochemistry 143, no. 3 (2007): 279–86. http://dx.doi.org/10.1093/jb/mvn001.

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40

Werner, Hendrikje, and Colin Stewart. "Dynamic composition of the nuclear envelope during mouse pre-implantation development." Mechanisms of Development 145 (July 2017): S95—S96. http://dx.doi.org/10.1016/j.mod.2017.04.244.

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41

De Hertogh, R., I. Vanderheyden, S. Pampfer, D. Robin, and J. Delcourt. "Maternal insulin treatment improves pre-implantation embryo development in diabetic rats." Diabetologia 35, no. 5 (1992): 406–8. http://dx.doi.org/10.1007/bf02342434.

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42

Saitou, M., S. Kagiwada, and K. Kurimoto. "Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells." Development 139, no. 1 (2011): 15–31. http://dx.doi.org/10.1242/dev.050849.

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43

Chen, Mo, Zhaoyan Wang, Zhiwen Zhang, et al. "Intelligence development of pre-lingual deaf children with unilateral cochlear implantation." International Journal of Pediatric Otorhinolaryngology 90 (November 2016): 264–69. http://dx.doi.org/10.1016/j.ijporl.2016.09.031.

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44

Pashinskaya, E. S., I. S. Sobolevskaya, A. K. Pashinskaya, et al. "The significance of light chronodestruction in the development of the embryotoxic effect in the experiment." Health and Ecology Issues 21, no. 1 (2024): 75–80. http://dx.doi.org/10.51523/2708-6011.2024-21-1-09.

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Objective. To assess the significance of light chronodestruction in the development of the embryotoxic effect in the experiment. Materials and methods. The experiment was conducted on 60 female rats of the Wistar line. To assess the significance of chronodestruction in the development of embryotoxic effect, the uterus was isolated in the experiment, in which the number of implantation sites, the total number of embryos, the number of live and dead embryos, and the number of resorptions were estimated. The number of corpus luteum in the harvested ovaries was estimated. In addition, the mean emb

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45

Chin, P. Y., J. G. Thompson, and S. A. Robertson. "172. A MODEST INFLAMMATORY INSULT IN THE PRE-IMPLANTATION PERIOD ALTERS OVIDUCT CYTOKINE EXPRESSION AND PROGRAMS FETAL DEVELOPMENT." Reproduction, Fertility and Development 22, no. 9 (2010): 90. http://dx.doi.org/10.1071/srb10abs172.

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The cytokine milieu surrounding the pre-implantation embryo contributes to programming optimal embryo development. Perturbations to the maternal environment such as infection and inflammation during the pre-implantation period can influence cytokine synthesis and may cause changes in embryo development that compromise pregnancy outcome. We aimed to investigate the effect of an inflammatory insult with LPS during the pre-implantation period on later fetal development and the role of oviduct cytokine expression in mediating this response. LPS (at various doses of 0.5–62.5 μg) was administered i.

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Safoor, Iqra, Abdul Hakim, Shahid Iqbal, Sohail Babar Niazi, Nawal Khurshid, and Saleh Khurshied. "Factors Affecting the Development of Speech in Children After Cochlear Implant." Pakistan Armed Forces Medical Journal 74, no. 2 (2024): 260–64. http://dx.doi.org/10.51253/pafmj.v74i2.9375.

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Objective: To determine the odds of different factors for developing poor speech intelligibility in pre-lingually deaf children who have undergone cochlear implantation. Study Design: Case-control study. Place and Duration of Study: Department of ENT, Combined Military Hospital, Rawalpindi Pakistan, Jan 2020 to Aug 2022. Methodology: This study was based on a sample of 60 patients: 30 cases with cochlear implants placed before two years of age, with a total time of using a cochlear implant of ≥1 year, and 30 controls. Both groups consisted of both genders aged between 3 and 12 years. All patie

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47

Kulikov, Alexey, Sergey Zhad'ko, Inessa Romanenko, and Maksim Kriventsov. "PRE-IMPLANTATION GINGIVAL HISTOPATHOLOGICAL CHANGES: CLINICAL CASE SERIES." Actual problems in dentistry 19, no. 2 (2023): 59–67. http://dx.doi.org/10.18481/2077-7566-2023-19-2-59-67.

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An inflammatory process in the gingival and/or periodontal tissues prior to implantation seems to be a significant risk factor contributing to impaired osteointegration with implant rejection in the early or late stages due to the development of periimplantation mucositis followed by periimplantitis. In this regard, the task of searching for highly informative markers, both morphological and laboratory, as well as molecular genetic markers, remains extremely relevant, allowing predicting the risk of developing periimplantitis in various populations. An equally urgent task is the search for eff

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48

Shi, Yu, Mingcheng Cai, Kun Du, et al. "Dynamics of Known Long Non-Coding RNAs during the Maternal-to-Zygotic Transition in Rabbit." Animals 11, no. 12 (2021): 3592. http://dx.doi.org/10.3390/ani11123592.

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The control of pre-implantation development in mammals undergoes a maternal-to-zygotic transition (MZT) after fertilization. The transition involves maternal clearance and zygotic genome activation remodeling the terminal differentiated gamete to confer totipotency. In the study, we first determined the profile of long non-coding RNAs (lncRNAs) of mature rabbit oocyte, 2-cell, 4-cell, 8-cell, and morula embryos using RNA-seq. A total of 2673 known rabbit lncRNAs were identified. The lncRNAs exhibited dynamic expression patterns during pre-implantation development. Moreover, 107 differentially

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49

Hwang, In-Sul, Joohyun Shim, Keon Bong Oh, Haesun Lee, and Mi-Ryung Park. "cd26 Knockdown Negatively Affects Porcine Parthenogenetic Preimplantation Embryo Development." Animals 12, no. 13 (2022): 1662. http://dx.doi.org/10.3390/ani12131662.

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cd26 is ubiquitously distributed in the body, particularly in the endothelial and epithelial cells, with the highest expression in the kidney, liver, and small intestine. In humans, cd26 serves as a marker for the embryo implantation phase. However, little is known about the role of cd26 in porcine pre-implantation embryo development. Here, we aimed to examine siRNA-induced cd26 downregulation in the cytoplasm of MII oocytes, to determine whether cd26 is involved in the regulation of porcine pre-implantation embryonic development. The cd26 siRNA was micro-injected into the cytoplasm of MII ooc

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50

Travnickova, Ivona, Pavlina Hulinska, Zbysek Sladek, Mariusz T. Skowronski, and Marie Machatkova. "Changes of the zona pellucida patterns during oocyte maturation, fertilization and embryo development in mammals: mini-review." Medical Journal of Cell Biology 10, no. 1 (2022): 23–28. http://dx.doi.org/10.2478/acb-2022-0004.

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Abstract The mammalian zona pellucida (ZP) is an extracellular matrix that surrounds immature and mature oocytes and early embryos until the stage of a blastocyst and its implantation. This mini-review summarizes basic information on the ZP and its morphologic and functional changes during in vitro oocyte maturation and fertilization and in vivo pre-implantation embryo development.

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