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Journal articles on the topic 'Pre-transfusion tests'

Author: Grafiati

Published: 8 September 2021

Last updated: 29 July 2025

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1

Ferraz, Ana, Vítor Carvalho, José Machado, and José Brito. "Mechatronic system for performing blood pre-transfusion tests." Sensors and Actuators A: Physical 246 (August 2016): 81–90. http://dx.doi.org/10.1016/j.sna.2016.05.022.

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2

Meža, Marko, Marko Breskvar, Andrej Košir, Irena Bricl, Jurij Tasič, and Primož Rožman. "Telemedicine in the blood transfusion laboratory – remote interpretation of pre-transfusion tests." Journal of Telemedicine and Telecare 13, no. 7 (2007): 357–62. http://dx.doi.org/10.1258/135763307782215370.

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We have developed a telemedicine system for blood transfusion work, to supply the local hospital laboratory with an expert opinion from the central reference laboratory. The telemedicine system allows remote inspection and interpretation of pre-transfusion tests, which are performed by ID-cards (micro-tube gel technology). The system was installed at three blood transfusion laboratories in Slovenia, approximately 70 km apart. Validation of the telemedicine system was performed using 99 clinical cases selected randomly from routine work. Two groups of immunohaematology specialists participated.

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3

Regina Belem Lermen, Amanda, Daiane Cobianchi da Costa, Edneia Casagranda Bueno, Larissa Pucci Vieira, and Alexandre Geraldo. "Evaluation of transfusion incidents and near-misses in a hospital on the coast of Santa Catarina." Hematology & Transfusion International Journal 10, no. 3 (2022): 1–6. http://dx.doi.org/10.15406/htij.2022.10.00282.

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Transfusion medicine is not free of risks and their source could be both technical and human. The near-miss is a deviation from a procedure detected before its occurrence, which could result in an erroneous transfusion and/or a transfusion reaction. The incidents in turn comprise the deviations in the security policy, leading to inadequate transfusions. This study aimed to evaluate transfusion incidents and near-misses of a transfusion agency on the coast of Santa Catarina, Brazil. The pre-analytical, analytical and post-analytical phases of the pre-transfusion tests and transfusion procedure

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4

Holland, Paul V. "Old and New Tests: Where Will It End?" Vox Sanguinis 78, S2 (2000): 67–70. http://dx.doi.org/10.1111/j.1423-0410.2000.tb00040.x.

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Testing has improved the safety of the blood supply. We have excellent serologic tests in place now and are implementing nucleic acid based tests to identify asymptomatic carriers of viruses during the infectious part of the pre‐seroconversion (window) period. However, the blood supply was already quite safe after a variety of other mechanisms had been put into place besides testing to screen out individuals at risk of carrying the most important transfusion transmissible agents. An important safety factor is the use of volunteer, unpaid (unremunerated) blood donors. The best alternative to im

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5

Tenorio, Maria, Gemma Moreno Jiménez, Valentín García Gutiérrez, et al. "Validation of Daraex to Resolve Daratumumab-Induced Interferences in Pre-Transfusion Screen Tests." Blood 134, Supplement_1 (2019): 4983. http://dx.doi.org/10.1182/blood-2019-131345.

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Daratumumab is a CD38-directed antibody increasingly used for the treatment of adult patients with multiple mieloma. The membrane of red blood cells express CD38 and thus samples from patients treated with daratumumab show agglutination in red blood cell antibody screen tests performed prior to transfusion. This interference hinders the detection of red blood cell alloantibodies. Published literature has described a method to eliminate CD38 in red blood cells with DTT (Chapuy, 2016). This technique is cumbersome, requires positive and negative controls as DTT destroys Kell antigens and can pro

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6

Solves Alcaina, Pilar, and Pedro Asensi Cantó. "Interference of Monoclonal Antibody Therapy in Transfusion: An Update." Hemato 5, no. 3 (2024): 220–29. http://dx.doi.org/10.3390/hemato5030018.

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Monoclonal antibody (MoAb) therapy has been increasingly used in recent years for hematologic malignancies. The MoAbs anti-CD38 and anti-CD47 are immunoglobulins directed against epitopes that are highly expressed not only on cancer cells, but also on red blood cells (RBCs), as well as platelets. Additionally, producing an off-target effect interferes in pre-transfusion testing, having the potential to unchain hemolytic anemia. Blood banks must assure the availability and safety of blood products for patients in need. Thus, MoAbs have become a challenge for blood banks, since methods to overco

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7

Raos, Mirela, Jurjana Novoselac, Iva Lucija Burnać, Marija Lukić, Ivana Leskovar, and Branka Golubić Ćepulić. "Evaluation of antibody screening and identification pre-transfusion tests using DG Gel cards." Journal of Applied Health Sciences 4, no. 2 (2018): 179–86. http://dx.doi.org/10.24141/1/4/2/4.

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8

Mburu, Joy Muthoni, Natalie Pitch, Hana Al-Julaih, and Suzan Williams. "Comparison of the Efficacy of Simple, Partial Manual and Automated Exchange Transfusions in the Management of Sickle Cell Disease in Pediatric Patients." Blood 138, Supplement 1 (2021): 4283. http://dx.doi.org/10.1182/blood-2021-154368.

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Abstract Background: Chronic transfusion therapy in sickle cell disease is used to prevent complications of sickle cell disease by reducing hemoglobin S levels, most commonly used for primary or secondary stroke prophylaxis, amongst other indications. Transfusions can be completed as simple, partial manual exchange or automated exchange.Comparative evidence on the long term efficacy of simple, partial manual or automated exchange in the management of children with sickle cell disease is lacking. Methods: A retrospective study of patients aged less than 18 years with a diagnosis of sickle cell

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9

Park, Insu, Woong Sik Jang, Chae Seung Lim, and Jeeyong Kim. "Evaluation of Pre-Transfusion Crossmatch Test Using Microscanner C3." Diagnostics 14, no. 12 (2024): 1231. http://dx.doi.org/10.3390/diagnostics14121231.

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A pre-transfusion crossmatch test is crucial for ensuring safe blood transfusions by identifying the compatibility between donor and recipient blood samples. Conventional tube methods for crossmatching have limitations, including subjectivity in result interpretation and the potential for human error. In this study, we evaluated the diagnostic performance of a new crossmatch test using Microscanner C3, which can overcome these shortcomings. The crossmatch test results using the method were obtained in 323 clinical samples. The sensitivity, specificity, positive predictive value, negative predi

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10

Hourani, Layla, Christiane Weingart, and Barbara Kohn. "Alloimmunisation in transfused patients: serial cross-matching in a population of hospitalised cats." Journal of Feline Medicine and Surgery 19, no. 12 (2017): 1231–37. http://dx.doi.org/10.1177/1098612x16688574.

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Objectives Cross-matching is currently recommended as part of pre-transfusion testing for repeat transfusions in cats 4 days after having received an initial transfusion. This prospective study determined when and if cats developed positive cross-match (CM) results after having been transfused with AB-compatible blood. Methods Donors were selected according to standard transfusion safety protocols. Twenty-one hospitalised anaemic recipients (blood type A: n = 20; blood type B: n = 1) received 1–4 (median 2) whole blood transfusions (WBTs) over 1–6 days (median 2) in 33 transfusion instances. T

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11

Khalaf- Adeli, Elham, Mostafa Alavi, Alireza Alizadeh-Ghavidel, and Ali Akbar Pourfathollah. "Comparison of Standard Coagulation Testing with Thromboelastometry Tests in Cardiac Surgery." Journal of Cardiovascular and Thoracic Research 11, no. 4 (2019): 300–304. http://dx.doi.org/10.15171/jcvtr.2019.48.

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Introduction: According to the several evidences, using thromboelastometry as a point of care test canbe effective in reduction in blood loss and transfusion requirements in cardiac surgeries. However,there are limited data regarding to the comparison of thromboelastometry and the standard coagulationtests. In this study, we compared thromboelastometry and standard coagulation tests (PT, PTT andfibrinogen level) in patients under combined coronary-valve surgery. Methods: Forty adult patients who were under on-pump combined coronary-valve surgery wereincluded in this study. Thromboelastometry t

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12

Natukunda, Bernard, Robert Wagubi, Ivan Taremwa, et al. "The utility of ‘home-made’ reagent red blood cells for antibody screening during pre-transfusion compatibility testing in Uganda." African Health Sciences 21, no. 2 (2021): 782–87. http://dx.doi.org/10.4314/ahs.v21i2.38.

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Background: The WHO recommends that pre-transfusion testing should include ABO/RhD grouping followed by screen- ing for red blood cell (RBC) alloantibodies using the indirect antiglobulin test (IAT). However, in Uganda, current practice does not include RBC alloantibody screening. Objective: To assess the utility of ‘home-made’ reagent RBCs in alloantibody screening. Materials and methods: In a laboratory-based study, group O RhD positive volunteer donors were recruited and their extended phenotype performed for C, c, E, e, K, Fya, Fyb Jkb, S and s antigens. These ‘home-made’ reage

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13

Kino, Shuichi, Yutaka Tomoda, Yoshihisa Itoh, Hidenori Karasaki, and Shinichi Kasai. "IMPLEMENTATION OF PRE- AND POST-TRANSFUSION VIRAL MARKER TESTS AT ASAHIKAWA MEDICAL COLLEGE HOSPITAL." Japanese Journal of Transfusion and Cell Therapy 55, no. 1 (2009): 21–28. http://dx.doi.org/10.3925/jjtc.55.21.

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14

Vasavi, Perada, Mahesh Kumar Usha, and Anurag Yadav. "Role of training session in improving the knowledge of blood transfusion practices among undergraduates- a hospital based study." Journal of Pathology of Nepal 10, no. 2 (2020): 1702–5. http://dx.doi.org/10.3126/jpn.v10i2.29827.

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Background: Blood is a vital and limited resource with a lifesaving therapeutic benefit. Knowledge of standard transfusion practices to be followed is important in delivering quality transfusion services. The present study aims at assessing the knowledge of transfusion practices among undergraduate medical students, train them, and to assess the impact of this type of training sessions in improving the outcome. Materials and methods: 82 undergraduate MBBS students participated in the study. The students were asked to attempt a pre-test and a post-test questionnaire before and after the t

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15

Dhabangi, Aggrey, Ezra Musisi, and Dorothy Kyeyune. "Improving blood transfusion safety in resource-poor countries: a case study of using leucocyte reduced blood in Uganda." African Health Sciences 20, no. 2 (2020): 977–83. http://dx.doi.org/10.4314/ahs.v20i2.54.

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Background: The majority of blood transfusion safety strategies recommended by the WHO for resource-poor countries focus mainly on reducing the risk of transfusion-transmitted infections (TTIs). Other technologies such as leucocyte reduc- tion may represent complementary strategies for improving transfusion safety. Objective: To evaluate the role of using leucocyte reduced blood in a resource-poor country. Methods: Pre-storage leucocyte reduced (LR) red blood cells (RBCs) were specially prepared for the Tissue Oxygenation by Transfusion in severe Anaemia and Lactic acidosis (TOTAL)

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16

Damulak, O. D., E. D. Jatau, E. Ekam, et al. "Blood Transfusion Service and Hospital Blood Rotation: The Implications on Transfusion Safety in Nigeria." Journal of BioMedical Research and Clinical Practice 2, no. 1 (2019): 19–24. http://dx.doi.org/10.46912/jbrcp.107.

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Blood donation is not readily an altruistic sacrifice in sub-Saharan Africa where microbial infections, maternal haemorrhages, malaria and other tropical diseases that frequently require blood transfusion are daily diagnoses. Blood transfusion safety is hindered by the combined prevailing high rate of Transfusion-Transmissible Infections (TTIs) and poor screening techniques. This study determined the rate of Enzyme-Linked Immuno-Sorbent Assay (ELISA) positive reactions to transfusion-transmissible infections in rapid diagnostic test negative family replacement blood units, compared to the firs

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17

Damulak, O. D., E. D. Jatau, E. Ekam, et al. "Blood Transfusion Service and Hospital Blood Rotation: The Implications on Transfusion Safety in Nigeria." Journal of BioMedical Research and Clinical Practice 2, no. 1 (2019): 19–24. http://dx.doi.org/10.46912/jbrcp.v2.i1.2019.107.

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Blood donation is not readily an altruistic sacrifice in sub-Saharan Africa where microbial infections, maternal haemorrhages, malaria and other tropical diseases that frequently require blood transfusion are daily diagnoses. Blood transfusion safety is hindered by the combined prevailing high rate of Transfusion-Transmissible Infections (TTIs) and poor screening techniques. This study determined the rate of Enzyme-Linked Immuno-Sorbent Assay (ELISA) positive reactions to transfusion-transmissible infections in rapid diagnostic test negative family replacement blood units, compared to the firs

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18

Damulak, O. D., E. D. Jatau, E. Ekam, et al. "Blood Transfusion Service and Hospital Blood Rotation: The Implications on Transfusion Safety in Nigeria." Journal of BioMedical Research and Clinical Practice 2, no. 1 (2019): 19–24. http://dx.doi.org/10.46912/jbrcp2i1.2019107.

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Blood donation is not readily an altruistic sacrifice in sub-Saharan Africa where microbial infections, maternal haemorrhages, malaria and other tropical diseases that frequently require blood transfusion are daily diagnoses. Blood transfusion safety is hindered by the combined prevailing high rate of Transfusion-Transmissible Infections (TTIs) and poor screening techniques. This study determined the rate of Enzyme-Linked Immuno-Sorbent Assay (ELISA) positive reactions to transfusion-transmissible infections in rapid diagnostic test negative family replacement blood units, compared to the firs

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19

O. Ondondo, Beatrice. "Management of Major Obstetric Haemorrhage using ROTEM Point-of-Care Haemostasis Analysers Can Reduce Blood Product usage Without Increasing Fibrinogen Replacement Therapy." Biomedical and Pharmacology Journal 11, no. 3 (2018): 1167–76. http://dx.doi.org/10.13005/bpj/1478.

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Major obstetric haemorrhage (MOH) is a leading cause of maternal death and morbidity, with the majority of deaths occurring within four hours of delivery. Therefore, prompt identification of women at risk of MOH is crucial for the rapid assessment and management of blood loss to urgently restore haemodynamic stability. Furthermore, as the rate of blood loss during MOH can increase rapidly in the time when laboratory results are awaited, the management of MOH could benefit from point-of-care coagulation testing by the ROTEM analyser which has a quicker turnaround time compared to standard labor

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20

Goy-Thollot, I., U. Giger, C. Boisvineau, et al. "Pre- and Post-Transfusion Alloimmunization in Dogs Characterized by 2 Antiglobulin-Enhanced Cross-match Tests." Journal of Veterinary Internal Medicine 31, no. 5 (2017): 1420–29. http://dx.doi.org/10.1111/jvim.14801.

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21

Girianto, Pria Wahyu Romadhon, and Mega Wahyu Mulyasari. "The Effectiveness of Durante Hemodialysis Packed Red Cells (PRC) Transfusion on Hemoglobin Levels." Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) 8, no. 1 (2021): 013–18. http://dx.doi.org/10.26699/jnk.v8i1.art.p013-018.

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Renal Disease was a chronic disease that the most attacking people in Indonesia. Damage to this vital organ in the human body greatly affected a person's health condition, one of which was anemia. This study aimed to determine the effectiveness of Durante hemodialysis PRC transfusions on hemoglobin levels. The method used was Pre-experimental design, with the One group pre-post test design approach. With a sample of 49 patients who underwent regular hemodialysis at RSUD dr. Iskak Tulungagung. Data were obtained by direct observation. Processed by computerized methods with a statistical t-test,

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22

Detterich, Jon, Adam Bush, Roberta Miyeko Kato, et al. "Elevated Tricuspid Regurgitation Jet Correlates with Decreased Brachial Artery Relaxivity In Sickle Cell Anemia Patients on Chronic Transfusion Therapy." Blood 116, no. 21 (2010): 1645. http://dx.doi.org/10.1182/blood.v116.21.1645.1645.

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Abstract Abstract 1645 Introduction: Vascular disease in both pulmonary and systemic vessels underlies most complications of sickle cell anemia (SCA). Multiple mechanisms contribute to this process, including inflammation, oxidative stress and decreased nitric oxide bioavailability. Chronic transfusion therapy (CTT) is thought to ameliorate some of these factors. Our goal was to determine the relationship between systemic vascular function, as indexed by flow mediated dilation (FMD), and elevated tricuspid regurgitation jet (TRJ) as a surrogate for pulmonary hypertension (PH), in chronically t

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23

Begum, Nilufar, Md Yunus Ali, and Amdadul Haque. "Study on Screening tests among the Blood donors in Community Based Medical College Hospital, Mymensingh, Bangladesh." Community Based Medical Journal 8, no. 1 (2019): 19–22. http://dx.doi.org/10.3329/cbmj.v8i1.55665.

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The aim of the study was to find out the prevalence of transfusion transmitted diseases (TTD) in voluntary and Replacement donors. A total of 4,885 donors were analyzed for the prevalence of TTD over a period of 1 year and 9 month from August 2016 to May 2018, Conducted at the Community Based Medical College Hospital, Mymensingh, Bangladesh, of these 38.8% were voluntary donors and 61.2% were replacement donors. Prevalence of Hepatitis B virus (HBv) was highest (.86%) followed by syphilis (.3%), HCV (.14%), Malaria (.06%) and HIV (.04%). Prevalence was more in male replacement donors. Seroposi

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Al-Enizi, Hadia Farhan Al-Dahmeshi, Aref Awad Al-Shammari, Mohammed Shabout Al-Shammari, and Eidah Adehim Ageel Al-Dhafiry. "The Effect of Viruses on Blood Transfusion, an Applied Study on the Hafr Al-Batin Blood Bank." Saudi Journal of Pathology and Microbiology 7, no. 12 (2022): 446–56. http://dx.doi.org/10.36348/sjpm.2022.v07i12.001.

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The fact that blood groups can act as receptors/coreceptors for bacteria, viruses, and parasites demonstrates the importance of blood groups in infection. Blood group antigens also aid in cell adsorption, signal transmission, and/or membrane micro-domain retention. Furthermore, blood type can influence the innate immune response to infection. This data was compiled using the risk perception of blood transfusion scale, which is part of a larger risk perception questionnaire. Blood transfusion risk perception is measured on a 7-point Likert scale based on a set of qualitative characteristics; 11

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KANDER, T., A. FRIGYESI, J. KJELDSEN-KRAGH, H. KARLSSON, F. ROLANDER, and U. SCHÖTT. "Bleeding complications after central line insertions: relevance of pre-procedure coagulation tests and institutional transfusion policy." Acta Anaesthesiologica Scandinavica 57, no. 5 (2013): 573–79. http://dx.doi.org/10.1111/aas.12075.

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26

Shahjahan, Md, Khondaker Mahbub Elahi, Tamima Hossain та Md Rabiul Awal. "Cardiovascular Assessment Before and After Splenectomy in β-Thalassemia: A Longitudinal Study". Scholars Journal of Applied Medical Sciences 13, № 05 (2025): 1045–49. https://doi.org/10.36347/sjams.2025.v13i05.007.

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Background: β-Thalassemia is a hereditary hemoglobin disorder characterized by chronic hemolytic anemia and increased transfusion dependency. Splenectomy is often performed in patients with massive splenomegaly, hypersplenism, or excessive transfusion requirements to reduce hemolysis and improve hematological parameters. However, its impact on cardiac function and post-splenectomy complications remains a subject of concern. This study aims to evaluate the hematological, echocardiographic, and cardiovascular changes before and after splenectomy in β-thalassemia patients. Methods: A longitudinal

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27

Detterich, Jon A., Suvimol Sangkatumvong, Roberta Kato, et al. "Acute Hemodynamic and Vascular Effects of Transfusion in Chronically Transfused Patients with Sickle Cell Anemia." Blood 114, no. 22 (2009): 1516. http://dx.doi.org/10.1182/blood.v114.22.1516.1516.

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Abstract Abstract 1516 Poster Board I-539 Introduction Patients with sickle cell anemia (SCA) who are at risk for stroke or develop recurrent episodes of acute chest are often placed on chronic transfusion therapy. The acute hemodynamic and vascular consequences of transfusion are poorly characterized. In order to better characterize chronic changes in these patients, it is important to understand the acute changes involved with this intervention. Methods We enrolled SCA patients who are on chronic transfusion therapy in a prospective study to determine the cardiovascular effects of a single t

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Rodrigues, Ana Beatriz Frota Lima, Samia Valéria Ozorio Dutra, Maria Ivaneide Teixeira dos Santos, et al. "The Effects of the Clinical Simulation of Transfusion Reactions on Nursing Students’ Knowledge Gain: A Pragmatic Clinical Trial." Education Sciences 15, no. 6 (2025): 693. https://doi.org/10.3390/educsci15060693.

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Background: Blood transfusion is a therapeutic procedure characterized by the use of blood components for the treatment of certain pathologies. When applied properly, it is highly successful; however, it also has risks, such as transfusion reactions. Objective: This study aimed to evaluate the effects of the clinical simulation of transfusion reactions on the knowledge gain of nursing students. Methods: Two groups were compared: the intervention group, which used the educational intervention: “clinical simulation of transfusion reactions in adults”, and the control group, which did not use the

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29

Dilberović, Admir, Lidija Kola, and Ivan Kola. "The importance of removing interference caused by Darzalex® (daratumumab) in pre-transfusion testing." Journal of Health Sciences 13, no. 3 (Suplement 1) (2024): 243–45. http://dx.doi.org/10.17532/jhs.2023.2612.

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Introduction: Multiple myeloma (MM) is a hematologic malignacy characterized by the uncontrolled proliferation of abnormal plasma cells in the bone marrow. Darzalex® (daratumumab) has emerged as a highly effective therapeutic agent for MM, offering an additional treatment option for patients who have developed resistance to other therapies. However, the use of Darzalex® poses challenges in pre-transfusion testing due to its strong binding affinity of the monoclonal anti-CD38 antibody to CD38 protein, resulting in panreactivity with test erythrocytes and complicating the detection of erythrocyt

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Inomata, Makiko, Chiduru Yamaguchi, Machiko Yamamoto, and Junichi Kitazawa. "ESTABLISHMENT OF A SYSTEM FOR IMPROVING THE IMPLEMENTATION RATE OF PRE- AND POST-TRANSFUSION VIRAL INFECTION TESTS." Japanese Journal of Transfusion and Cell Therapy 56, no. 6 (2010): 702–8. http://dx.doi.org/10.3925/jjtc.56.702.

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31

Kiyokawa, Tomoko, Kotarosumitomo Nakayama, Mika Hosokawa, et al. "RESULTS OF PRE- AND POST-TRANSFUSION TESTS FOR INFECTIOUS DISEASE AT OSAKA UNIVERSITY HOSPITAL AND FUTURE PROSPECTS." Japanese Journal of Transfusion and Cell Therapy 66, no. 3 (2020): 577–82. http://dx.doi.org/10.3925/jjtc.66.577.

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32

Chou, Stella T., Julia Mewha, David F. Friedman, et al. "Real-World Feasibility of RH Genotype-Matched Red Blood Cells for Chronically Transfused Patients with Sickle Cell Disease." Blood 142, Supplement 1 (2023): 1291. http://dx.doi.org/10.1182/blood-2023-179238.

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Introduction Most red blood cell (RBC) alloimmunization in sickle cell disease (SCD) is caused by sensitization to Rh (D, C, c, E, and e) and K antigens. Provision of serologic Rh and K-matched RBCs has reduced but not eliminated Rh alloantibody formation due to the high genetic variation within the RH loci in Blacks. Over 85% of patients with SCD, as well as Black donors needed to support CEK matching programs, have variant RHD or RHCE alleles that result in loss or alteration of Rh antigens. These variant Rh proteins are not detected by standard serologic tests, and thus, genetically matched

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Meijden, Paola E. J. van der, René van Oerle, Joyce Curvers, Elisabeth C. M. van Pampus, Saskia E. M. Schols, and Johan W. M. Heemskerk. "Increased thrombin generation and fibrinogen level after therapeutic plasma transfusion: Relation to bleeding." Thrombosis and Haemostasis 99, no. 01 (2008): 64–70. http://dx.doi.org/10.1160/th07-07-0438.

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SummaryIn a clinical setting, fresh frozen plasma (FFP) is transfused to diluted patients with complicated surgery or trauma, as guided by prolonged conventional coagulation times or low fibrinogen levels. However, the limited sensitivity of these coagulation tests may restrict their use in measuring the effect of transfusion and hence predicting the risk of perioperative bleeding. We used the more sensitive, calibrated automated thrombogram (CAT) method to evaluate the result of therapeutic FFP transfusion to 51 patients with dilutional coagulopathy. Thrombin generation was measured in pre- a

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Warner, Matthew A., Ian J. Welsby, Phillip J. Norris, et al. "Point-of-care washing of allogeneic red blood cells for the prevention of transfusion-related respiratory complications (WAR-PRC): a protocol for a multicenter randomised clinical trial in patients undergoing cardiac surgery." BMJ Open 7, no. 8 (2017): e016398. http://dx.doi.org/10.1136/bmjopen-2017-016398.

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IntroductionThe transfusion-related respiratory complications, transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO), are leading causes of transfusion-related morbidity and mortality. At present, there are no effective preventive strategies with red blood cell (RBC) transfusion. Although mechanisms remain incompletely defined, soluble biological response modifiers (BRMs) within the RBC storage solution may play an important role. Point-of-care (POC) washing of allogeneic RBCs may remove these BRMs, thereby mitigating their impact on post-transfus

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Cahill, Chris, Priya Jegatheesan, Dongli Song, et al. "Implementing Higher Phototherapy Thresholds for Jaundice in Healthy Infants 35 Plus Weeks." Hospital Pediatrics 13, no. 9 (2023): 857–64. http://dx.doi.org/10.1542/hpeds.2022-007098.

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OBJECTIVES To determine the impact of higher bilirubin thresholds on testing and treatment of healthy infants during the neonatal period. METHODS This quality improvement study included infants born at ≥35 weeks gestation and admitted to the well-baby nursery between July 2018 and December 2020. We assessed the transition from infants treated according to the 2004 AAP guidelines (pregroup) with those following the Northern California Neonatal Consortium guidelines (postgroup). We examined the proportion of infants receiving phototherapy and total serum bilirubin (TSB) assessments as outcome me

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Karkouti, Keyvan, Stuart A. McCluskey, Jeannie Callum, et al. "Evaluation of a Novel Transfusion Algorithm Employing Point-of-care Coagulation Assays in Cardiac Surgery." Anesthesiology 122, no. 3 (2015): 560–70. http://dx.doi.org/10.1097/aln.0000000000000556.

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Abstract Background: Cardiac surgery requiring the use of cardiopulmonary bypass is frequently complicated by coagulopathic bleeding that, largely due to the shortcomings of conventional coagulation tests, is difficult to manage. This study evaluated a novel transfusion algorithm that uses point-of-care coagulation testing. Methods: Consecutive patients who underwent cardiac surgery with bypass at one hospital before (January 1, 2012 to January 6, 2013) and after (January 7, 2013 to December 13, 2013) institution of an algorithm that used the results of point-of-care testing (ROTEM®; Tem Inter

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Abel, Gregory A., Heidi D. Klepin, Emily S. Magnavita, et al. "Feasibility of Peri-Transfusion Quality of Life Assessment for Patients with Myelodysplastic Syndromes." Blood 136, Supplement 1 (2020): 25–26. http://dx.doi.org/10.1182/blood-2020-139919.

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BACKGROUND: Decreased quality of life (QOL) due to fatigue in the setting of anemia is common with myelodysplastic syndromes (MDS), often leading to dependence on red blood cell (RBC) transfusions. Moreover, the COVID-19 pandemic has resulted in considerably reduced blood supply such that the importance of conserving donor RBCs for patients particularly in need is even more crucial (Shander, Anesth Analg 2020). While some patients with MDS experience improved QOL after transfusions, many do not, even at the same ECOG performance status (PS) and hemoglobin (Hb). In a pilot study, we sought to a

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Jarisch, Andrea, Jan Soerensen, Emilia Salzmann, et al. "Safety and Tolerability of Donor Type Red Blood Cell Transfusion before Allogeneic Stem Cell Transplantation in Children with Major ABO Mismatch." Blood 128, no. 22 (2016): 3415. http://dx.doi.org/10.1182/blood.v128.22.3415.3415.

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Abstract Background Major ABO mismatch in allogeneic bone marrow transplant (BMT) can cause clinical problems like severe transfusion reactions, acute haemolysis, and delay of red blood cell (RBC) engraftment or manifestation of pure red cell aplasia, related to circulating isoagglutinin titers. Even there is no increased incidence of graft failure or slower engraftment of neutrophils and platelets ABO mismatch leads to an increase of transplant related mortality. To reduce circulating isoagglutinin titers pre transplant plasma exchange during conditioning period can be performed. This procedu

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Tikhomirov, D. S., T. A. Tupoleva, A. A. Gulyaeva, et al. "A comprehensive measures ensuring the safety of blood component transfusions." Russian journal of hematology and transfusiology 65, no. 3 (2020): 312–34. http://dx.doi.org/10.35754/0234-5730-2020-65-3-321-334.

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Introduction. Human immunodefi ciency virus (HIV), Hepatitis B and C viruses (HBV, HCV) are the major blood-borne infections. Donor blood components cannot be currently replaced with synthetic substitutes, which determines the necessity of improving the viral safety of blood component transfusions.Aim. To describe a multicomponent system for monitoring the viral safety of donor blood component transfusions. General fi ndings. Measures ensuring the safety of blood component transfusions include the maintenance of regular communication with donors, pre-donation laboratory tests, viral screening,

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Dinić, Radovan, Nevenka Bujandrić, and Jasmina Grujić. "Prevalence and Specificity of Red Blood Cell Alloimmunization: Insights from Transfusion-Dependent Populations in Serbia." Thalassemia Reports 15, no. 2 (2025): 5. https://doi.org/10.3390/thalassrep15020005.

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Background/Objectives: Red blood cell (RBC) alloimmunization is a significant challenge in transfusion medicine, particularly among transfusion-dependent patients, such as those with thalassemia. It arises from the production of antibodies against non-self RBC antigens and can lead to complications like hemolytic transfusion reactions. This study aimed to evaluate the prevalence, specificity, and clinical implications of RBC alloimmunization at the University Clinical Center of Serbia (UCCS), emphasizing transfusion-dependent populations. Methods: This retrospective study analyzed 27,530 trans

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ABIDI, SAR, I. AHMED, T. RAZA, et al. "EFFECT OF PRE-OPERATIVE TRANEXAMIC ACID ADMINISTRATION ON POST-OPERATIVE HEMOGLOBIN LEVEL IN PERITROCHANTERIC FRACTURES." Biological and Clinical Sciences Research Journal 2024, no. 1 (2024): 867. http://dx.doi.org/10.54112/bcsrj.v2024i1.867.

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Peritrochanteric fractures, a common orthopaedic challenge, often necessitate surgical intervention to restore mobility and prevent complications in the elderly population. Despite advancements in surgical techniques, optimizing perioperative care remains critical to improving outcomes. Tranexamic acid (TXA), an antifibrinolytic agent, has effectively reduced blood loss and transfusion requirements in various surgical procedures. Objective: To assess the influence of pre-operative TXA administration on postoperative haemoglobin levels, intraoperative blood loss, transfusion rates, and adverse

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Ribkoff, Jessica, Thomas G. Deloughery, and Sven Reid Olson. "Incidence of False-Positive Direct Anti Globulin Tests (DAT): A Single-Center Retrospective Analysis." Blood 136, Supplement 1 (2020): 6. http://dx.doi.org/10.1182/blood-2020-143476.

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Background The direct antiglobulin test (DAT) is frequently ordered by both hematologists and non-hematology medical professionals in the workup of possible allo- or autoimmune hemolytic anemias. Frustratingly, positive DAT results in the absence of other abnormal blood hemolysis biomarkers can be challenging to interpret, as published data on the frequency of these "false-positive" DATs is limited. We sought to characterize the frequency of "false-positive" DATs and describe potential associations with co-morbid diseases, in order to better define the diagnostic accuracy of the DAT for allo-

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Obeidat, Mohammad, Omar Bashmaf, Sami Alrwashdeh, Faris Ababneh, and Suleiman Sharadgah. "Tranexamic acid with vitamin K mixture decreases bleeding of total hip arthroplasty in a Jordanian population." International Journal of Research in Orthopaedics 10, no. 6 (2024): 1148–52. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20243107.

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Background: Bleeding of total hip arthroplasty has severe consequences on postoperative recovery. 75–90% of early bleeding after surgery and during surgery is caused by operative technical issues. tranexamic acid decreases bleeding of arthroplasty. vitamin k has late and dose sensitive effect in clotting. Methods: This retrospective investigation included subjects of middle age and of both genders scheduled for primary hip replacement at Queen Alia hospital, Jordanian Royal medical services, between March 2022 and June 2023. Subjects were classified into two groups. Group I subject were admini

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Chiluka Sudhakar, Blessy Prabhu Priyanka S, Shanmuga Sundaram M, and Rajashekar K. "Clinical profile of transfusion-dependent thalassemia major children with reference to serum ferritin and liver function: A prospective observational study." Asian Journal of Medical Sciences 14, no. 11 (2023): 260–65. http://dx.doi.org/10.3126/ajms.v14i11.56668.

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Background: Thalassemia major is a genetic disorder characterized by severe anemia and the need for lifelong blood transfusions. Aims and Objectives: The aim of this study was to investigate the clinical profile of transfusion-dependent thalassemia major children with reference to serum ferritin levels and liver function. Materials and Methods: A prospective observational study included 100 children aged 1–12 years with beta-thalassemia major, who were receiving blood transfusions. Clinical data, including growth parameters, serum ferritin levels, and liver function tests, were collected. Desc

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Quarmyne, Maa-Ohui, Janet Figueroa, Courtney McCracken, Charles T. Quinn, Clark Brown, and Clinton H. Joiner. "Effect of Acute Transfusion on Cerebral Oxygenation in Patients with Sickle Cell Disease." Blood 130, Suppl_1 (2017): 988. http://dx.doi.org/10.1182/blood.v130.suppl_1.988.988.

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Abstract Introduction : The molecular abnormality in sickle hemoglobin (HbS) produces a unique cellular pathology characterized by fragile and rigid red blood cells which block the microcirculation, which, in concert with large vessel vasculopathy and the anemia of sickle cell disease (SCD), compromises oxygen delivery to the brain and other organs. Long-term, periodic transfusions are commonly used to prevent and ameliorate neurologic complications related to vasculopathy, particularly stroke. Despite widespread use of transfusions, little is known about the physiological effects on cerebral

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Pradhan Malla, Anagha, Padma Gurung, Sushma Lama, and Reena Shrestha Thapa. "Gynecologic surgery during the COVID-19 pandemic: Patan Hospital experience." Journal of Patan Academy of Health Sciences 8, no. 2 (2021): 25–31. http://dx.doi.org/10.3126/jpahs.v8i2.28537.

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Introduction: The COVID-19 pandemic is a major challenge for health care services including safe and effective surgery. This study aims to analyze gynecological surgery delivery during COVID-19 pandemic. Method: Data on gynecologic surgeries performed at Patan Hospital from 01 Jan to 31 Dec,2020 during pre-lockdown , lockdown and post-lockdown period of the COVID-19 pandemic were analyzed from medical record for surgical procedures, blood transfusion, ICU stay, length of hospital stay, mortality, COVID-19 PCR positive cases. Chi-square and Anova tests were used to compare between three p

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Wade, Jenna, Christina L. Dean, John D. Roback, and Harold C. Sullivan. "Diagnostic Management Team: Platelet Refractory Algorithm and Consult." American Journal of Clinical Pathology 152, Supplement_1 (2019): S6. http://dx.doi.org/10.1093/ajcp/aqz112.011.

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Abstract Platelet refractoriness occurs when a patient fails to achieve appropriate platelet count increment following platelet (plt) transfusion. Approximately 30% to 40% of cases are due to human leukocyte antigen (HLA) alloantibodies and 2% to 10% are due to human platelet antigen (HPA) alloantibodies, which can be detected by various assays. The results of these tests are then used to guide selection of appropriate units, such as crossmatch-compatible (XM) and HLA-matched (HLAm) plts. Given the various steps and tests involved in diagnosing and managing plt refractoriness, clinicians may o

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Li, Valery J., Shawn Lawrence Bailey, Morgan Bawcom-Randall, et al. "Safety and Efficacy of 14-Day Cold Stored Platelets in Reversing Effects of Aspirin." Blood 138, Supplement 1 (2021): 353. http://dx.doi.org/10.1182/blood-2021-148217.

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Abstract Background: Aspirin is an antiplatelet therapy used to reduce the risk of vascular occlusive events. However, this therapy is associated with an increased risk of bleeding for which there is no antidote currently. Transfusion of 5-day room stored platelets (RSP) at 22°C can reverse the effect of aspirin but surprisingly, the recent randomized PATCH trial showed increased morbidity and mortality for patients who received RSP transfusion for intracranial hemorrhage while on aspirin. Prior studies have shown that cold stored platelets (CSP) at 4°C are mildly activated and may participate

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Marques, Marisa B., Robinna G. Lorenz, and Lance A. Williams. "High Percentage of Evanescent Red Cell Antibodies in Patients with Sickle Cell Disease Highlights the Need for a National Antibody Database." Blood 126, no. 23 (2015): 3572. http://dx.doi.org/10.1182/blood.v126.23.3572.3572.

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Abstract Introduction: From 20 to 50% of patients with sickle cell disease are alloimmunized to red cell antigens from transfusions and/or pregnancies. Pre-transfusion testing (e.g. antibody screening) is essential to avoid hemolytic transfusion reactions from clinically significant antibodies, such as those to Rh, Kell, Duffy and Kidd antigens, among others. Unfortunately, alloantibodies may evanesce over time, becoming undetectable or even leading to a negative antibody screen. Furthermore, antibodies to low frequency antigens in the donor pool, mostly from Caucasians, may not be detected be

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R, Bindu Madhavi, Hanumanthappa A R, and Vishwanath G. "Seroprevalence of HIV, HBV, HCV and Syphilis among Blood donors at a tertiary care hospital." JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES 10, no. 1 (2020): 15–20. http://dx.doi.org/10.58739/jcbs/v10i1.6.

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Introduction: Blood transfusion is a lifesaving essential therapeutic procedure in many medical and surgical instances, as there is no genuine substitution. Even though it can save many human lives, in some instances it can transmit infectious diseases which are fatal. Amongst the undesirable complications due to blood transfu-sion, transmission of certain Transfusion Transmissible Infections (TTIs) like HIV, HBV, HCV and Syphilis are the most significant long term detrimental side effects. Hence meticulous pre transfusion testing and screening particularly for TTIs is the need of the hour. Ob

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