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Journal articles on the topic 'Precancerous disorder'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Meenapriya M and Deepika Rajendran. "Prevalence of oral potentially malignant disorders among adult population: A retrospective study." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 671–79. http://dx.doi.org/10.26452/ijrps.v11ispl4.4016.

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Oral potentially malignant disorders refer to both the precancerous lesions and precancerous conditions of the oral cavity. They possess the risk of cancer development in the oral cavity. Precancerous lesions and conditions are associated with various causative factors such as smoking, smokeless forms of tobacco etc. Early detection of oral, potentially malignant disorders can reduce the risk of development into oral cancer. Therefore, the purpose of this study is to find out the prevalence of oral, potentially malignant disorders among the adult population. The records were obtained through D

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Vasileva, Irina, and Viktor Bespalov. "PRECLINICAL AND CLINICAL STUDY OF EXTRACELLULAR DNA IN CANCER AND OTHER DISEASES ASSOCIATED WITH APOPTOSIS DISORDER." Problems in oncology 64, no. 3 (2018): 435–39. http://dx.doi.org/10.37469/0507-3758-2018-64-3-435-439.

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Oncological diseases at all stages of carcinogenesis are accompanied by violation of apoptosis processes. Drug and radiotherapy activates the apoptosis of tumor cells. This study presents the results of extracellular DNA changes after exposure to ionizing radiation and low-frequency noise are presented, administration of vitamins; in animals with benign prostatic hyperplasia, with ovarian cancer; in clinical studies in patients with chronic obstructive pulmonary disease, and in acute disorders of cerebral circulation. The possibilities of determination of extracellular DNA for the evaluation o

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Gupta, M., A. Pachauri, SK Singh, R. Ahuja, P. Singh, and SSS Mishra. "Recent Advancements in Oral Submucous Fibrosis Management: an Overview." Bangladesh Journal of Dental Research & Education 4, no. 2 (2014): 88–90. http://dx.doi.org/10.3329/bjdre.v4i2.20256.

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The management of Oral submucous fibrosis has been the subject of controversy ever since Schwartz first described the condition in 1952. It is potentially malignant disorder and crippling condition of oral mucosa. An attempt is made update the knowledge about the management of this precancerous condition with advancements which helps to reduce the mortality of oral cancer. DOI: http://dx.doi.org/10.3329/bjdre.v4i2.20256 Bangladesh Journal of Dental Research and Education Vol.4(2) 2014: 88-90

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Kohli, Sahil. "Various Treatment Modalities of Oral Lichen Planus: A Concise Review." International Journal of Research and Review 11, no. 6 (2024): 35–40. http://dx.doi.org/10.52403/ijrr.20240605.

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Oral Lichen Planus (OLP) is an autoimmune, mucocutaneous disorder present in the oral cavity. Besides oral mucosa, skin, scalp and genital mucosa can also get affected. Middle aged females are mostly affected. It is a precancerous lesion and its atrophic and erosive forms are painful. The patient can experience burning sensation and discomfort in such cases. It is chronic inflammatory disorder and it mostly affects adults. Cytotoxic T cells play an important role in its pathogenesis. This disorder is also triggered by viral and bacterial infections. The treatment plan aims in reducing the infl

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You, Jie-Ru, Ya-Ting Chen, Chia-Yu Hsieh, et al. "Exploring Possible Diagnostic Precancerous Biomarkers for Oral Submucous Fibrosis: A Narrative Review." Cancers 15, no. 19 (2023): 4812. http://dx.doi.org/10.3390/cancers15194812.

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Oral submucous fibrosis (OSF) stands as a progressive oral ailment, designated as a potentially malignant disorder. OSF has gained widespread recognition as a significant precursor to malignant transformation. In the pursuit of dependable, straightforward, and non-invasive diagnostic measures for the early detection of oral malignant progression, research has delved into potential diagnostic biomarkers of OSF. This comprehensive review delves into current investigations that explore the correlation between various biomarkers and OSF. The molecular biomarkers of OSF are categorized based on cyt

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Mosiychuk, L. M., O. M. Shevtsova, and O. P. Petishko. "Clinical and vegetative disorders, adaptive capacity and stress resistance in patients with precancerous conditions of the stomach in comorbidity with thyroid pathology." GASTROENTEROLOGY 55, no. 1 (2021): 1–6. http://dx.doi.org/10.22141/2308-2097.55.1.2021.229430.

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Background. An important aspect of the course of precancerous conditions of the stomach is comorbidity with thyroid pathology. To date, there is no consensus among researchers regarding the involvement of the autonomic nervous system in ensuring the reactivity of the body and the formation of adaptive processes in patients with atrophic gastritis combined with thyroiditis. The purpose was to determine the features of clinical manifestations, autonomic status and heart rate variability in patients with precancerous conditions of the stomach in comorbid thyroid pathology. Materials and methods.

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Shih, Yin-Hwa, Tong-Hong Wang, Tzong-Ming Shieh, and Yu-Hsin Tseng. "Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy." International Journal of Molecular Sciences 20, no. 12 (2019): 2940. http://dx.doi.org/10.3390/ijms20122940.

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Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5–15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, diagnostic biomarkers, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also impo

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Rubtsov, Vyacheslav A., Mariya N. Parygina, Sergey I. Mozgovoy, et al. "ARID1A as Marker of Precancerous Alterations in Gastric Mucosa." NAUKA MOLODYKH (Eruditio Juvenium) 13, no. 1 (2025): 5–14. https://doi.org/10.23888/hmj20251315-14.

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INTRODUCTION: Disorder in the function of the ARID1A gene is associated with the initiation and progression of many malignant tumors. In gastric cancer, ARID1A loss is noted in approximately 31% of all adenocarcinomas, in particular, in the subtype with microsatellite instability, indicating a probable potential for assessment of ARID1A protein for early diagnosis of early and pronounced precancerous alterations and gastric cancer. AIM: To compare the characteristics of ARID1A protein production in tissues of gastric adenocarcinoma and gastric mucosa in the distant zone of tumor growth to asse

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Indra G, Maragathavalli G, and Deepika Rajendran. "Complete Blood Count as a Diagnostic Marker in Oral Lichen Planus." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (2020): 1766–71. http://dx.doi.org/10.26452/ijrps.v11ispl3.3510.

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Oral precancerous lesions and conditions like oral lichen planus, leukoplakia, or oral submucous fibrosis have the potential to develop into oral cancer. Oral cancer accounts for approximately 3 % of all malignancies. Oral lichen planus is a premalignant condition occurring in the oral cavity due to various factors. Blood investigations are routinely done minimally invasive procedures carried out for various diagnostic purposes. The study aims to identify if the complete blood count (CBC) can be used as a pathologic diagnostic marker in an oral premalignant disorder like oral lichen planus. A

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Kim, Ji-Sun, Byung Guk Kim, and Se Hwan Hwang. "Efficacy of Artificial Intelligence-Assisted Discrimination of Oral Cancerous Lesions from Normal Mucosa Based on the Oral Mucosal Image: A Systematic Review and Meta-Analysis." Cancers 14, no. 14 (2022): 3499. http://dx.doi.org/10.3390/cancers14143499.

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The accuracy of artificial intelligence (AI)-assisted discrimination of oral cancerous lesions from normal mucosa based on mucosal images was evaluated. Two authors independently reviewed the database until June 2022. Oral mucosal disorder, as recorded by photographic images, autofluorescence, and optical coherence tomography (OCT), was compared with the reference results by histology findings. True-positive, true-negative, false-positive, and false-negative data were extracted. Seven studies were included for discriminating oral cancerous lesions from normal mucosa. The diagnostic odds ratio

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Soham, Kulkarni Sachin Jadhav Sahil Shaikh* Suraj Gholap. "A Review on Screening Model for Submucosa Fibrosis." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3445–56. https://doi.org/10.5281/zenodo.15475252.

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Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5–15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also important. Oral submu

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Pratt, Guy, Hannah V. Giles, and Jennifer H. Pinney. "Renal Disorders Associated with Waldenström Macroglobulinaemia, IgM MGUS and IgM-Producing B-Cell Lymphoproliferative Disorders." Hemato 4, no. 2 (2023): 184–95. http://dx.doi.org/10.3390/hemato4020015.

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Renal disorders are uncommonly associated with IgM MGUS and Waldenström macroglobulinaemia (WM). Data are limited to large case series that suggest that related renal involvement occurs in 5% of patients with WM. Although uncommon, there is a much greater variety of renal pathologies associated with WM and IgM MGUS than that seen in patients with multiple myeloma, where cast nephropathy predominates. In WM, uncommonly direct infiltration of the renal system by lymphoma or cast nephropathy with a high light-chain level can occur. AL amyloidosis can present with nephrotic syndrome as a feature w

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Peng, Chih-Yu, Yi-Wen Liao, Ming-Yi Lu, Chieh-Mei Yang, Pei-Ling Hsieh, and Cheng-Chia Yu. "Positive Feedback Loop of SNAIL-IL-6 Mediates Myofibroblastic Differentiation Activity in Precancerous Oral Submucous Fibrosis." Cancers 12, no. 6 (2020): 1611. http://dx.doi.org/10.3390/cancers12061611.

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Oral submucosal fibrosis (OSF) is a premalignant disorder of the oral cavity, and areca nut chewing is known to be a major etiological factor that could induce epithelial to mesenchymal transition (EMT) and activate buccal mucosal fibroblasts (BMFs). However, this detailed mechanism is not fully understood. In this study, we showed that the upregulation of Snail in OSF samples and fibrotic BMFs (fBMFs) may result from constant irritation by arecoline, a major alkaloid of the areca nut. The elevation of Snail triggered myofibroblast transdifferentiation and was crucial to the persistent activat

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Yu, Cheng-Chia, Yi-Wen Liao, Pei-Ling Hsieh, and Yu-Chao Chang. "Targeting lncRNA H19/miR-29b/COL1A1 Axis Impedes Myofibroblast Activities of Precancerous Oral Submucous Fibrosis." International Journal of Molecular Sciences 22, no. 4 (2021): 2216. http://dx.doi.org/10.3390/ijms22042216.

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Oral submucous fibrosis (OSF) is known as a potentially malignant disorder, which may result from chemical irritation due to areca nuts (such as arecoline). Emerging evidence suggests that fibrogenesis and carcinogenesis are regulated by the interaction of long noncoding RNAs (lncRNAs) and microRNAs. Among these regulators, profibrotic lncRNA H19 has been found to be overexpressed in several fibrosis diseases. Here, we examined the expression of H19 in OSF specimens and its functional role in fibrotic buccal mucosal fibroblasts (fBMFs). Our results indicate that the aberrantly overexpressed H1

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Li, Luyuan, John N. Jensen, Sara Szabo, Peter VanTuinen, and Sean M. Lew. "Recurrent giant cranial desmoid tumor in a 3-year-old boy with familial adenomatous polyposis requiring bifrontoparietal cranioplasty: case report." Journal of Neurosurgery: Pediatrics 18, no. 6 (2016): 703–7. http://dx.doi.org/10.3171/2016.6.peds15741.

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Desmoid tumors, also known as aggressive fibromatosis, are locally infiltrating musculoaponeurotic neoplasms arising in connective tissues. Desmoid tumors may be associated with familial adenomatous polyposis (FAP), a genetic disorder that presents with hundreds to thousands of precancerous colorectal polyps. The authors report the case of an 18-month-old boy who underwent resection of a right temporal desmoid tumor (initially diagnosed as cranial fasciitis) and developed a bilateral frontoparietal calvarial desmoid tumor 2 years later. The patient underwent gross-total resection of the tumor

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Aslam, Sidra, and Sarah Ghafoor. "Insulin-like growth factor-I signaling plays a pivotal role in the development of oral premalignant lesions in patients with diabetes mellitus." BioMedica 38, no. 3 (2022): 129–33. http://dx.doi.org/10.51441/biomedica/5-759.

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<p>Diabetes mellitus is a disorder of the metabolic system that is diagnosed by hyperglycemia and glucose intolerance. Diabetic patients are frequently prone to developing oral health complications, such as being at a higher risk for developing oral precancerous conditions like lichen planus, leukoplakia, and erythroplakia. Insulin-like growth factor-I (IGF-I) is a peptide hormone with a structure similar to insulin and belongs to the family of growth factors that play a vital role in the development of embryonic, postembryonic, and normal physiological functions of the human body. IGF-I

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Anthony, George, BS Sreenivasan, S. Sunil, et al. "Potentially Malignant Disorders of Oral Cavity." Oral and Maxillofacial Pathology Journal 2, no. 1 (2011): 95–100. https://doi.org/10.5281/zenodo.167066.

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Even though rapid advances have been made in the field of medicine and surgery, cancer is the leading cause for human mortality. It is estimated that more than one million new oral cancer cases are being detected annually in the Indian subcontinent, of which 90% are oral squamous cell carcinomas (OSCC). 60-70% of the Indian patients presented for treatment only in the advanced stage of oral cancer leading to the high mortality rate. Lack of public awareness about the signs, symptoms and risk factors, along with the absence of knowledge for early detection by health-care providers are believed

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Shi, Xiaolan, Zijiao Chen, Yi Yang, and Su Yan. "Bile Reflux Gastritis: Insights into Pathogenesis, Relevant Factors, Carcinomatous Risk, Diagnosis, and Management." Gastroenterology Research and Practice 2022 (September 12, 2022): 1–7. http://dx.doi.org/10.1155/2022/2642551.

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Bile reflux gastritis (BRG), a kind of gastrointestinal disorder in clinical practice, is characterized by regurgitation and inflammation. However, lack of guidelines leads to simple cognition and even ignorance of this disease for clinicians. Primarily, making the pathogenesis of BRG clear contributes to a correct and general understanding of this disease for physicians. Next, although recently there has been an increasing awareness among researchers in terms of the relevant factors for BRG, further studies involving large samples are still required to certify the relationship between them ex

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Nolano, Antonio, Giovanni Battista Rossi, Valentina D’Angelo, et al. "Germline Variants in MLH1 and ATM Genes in a Young Patient with MSI-H in a Precancerous Colonic Lesion." International Journal of Molecular Sciences 24, no. 6 (2023): 5970. http://dx.doi.org/10.3390/ijms24065970.

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Lynch syndrome (LS) is an autosomal dominant inherited disorder that primarily predisposes individuals to colorectal and endometrial cancer. It is associated with pathogenic variants in DNA mismatch repair (MMR) genes. In this study, we report the case of a 16-year-old boy who developed a precancerous colonic lesion and had a clinical suspicion of LS. The proband was found to have a somatic MSI-H status. Analysis of the coding sequences and flanking introns of the MLH1 and MSH2 genes by Sanger sequencing led to the identification of the variant of uncertain significance, namely, c.589-9_589-6d

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Kolenko, Y., and K. Malkivskyi. "Status of Periodontal Tissues in Patients with Diseases of the Oral Mucosa." SUCHASNA STOMATOLOHIYA 123, no. 6 (2024): 33. https://doi.org/10.33295/1992-576x-2024-6-33.

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Actuality. There is an axis of interaction between periodontitis and some oral mucosa lesions. For example, generalized periodontitis is closely related to lichen planus, a chronic inflammatory condition caused by an autoimmune disorder (i.e., the immune system mistakenly attacks the cells of the oral mucosa). The aim was to investigate the relationship between oral mucosa and periodontal diseases. Materials and methods. In 2024, 65 people aged 21–75 applied for examination and rehabilitation at the Department of Therapeutic Dentistry of the Bogomolets National Medical University. The main stu

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Ajay, K. Pillai, Raghuvanshi Vikalp, Dubey Siddarth, Kumar Rahmatker Akshay, Sahoo Anumita, and Kawadkar Dhwani. "Prevalence of Potentially Malignant Disorders of the Oral Cavity in Bhopal." PJSR 13, no. 2 (2020): 1–9. https://doi.org/10.5281/zenodo.8216905.

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Oral cancer is generally preceded by some benign lesions for a varying length of time. Many of them show high potential to become cancers, and therefore termed “precancerous”. Even though only small proportion of precancer actually progress to oral cancer, this development forms a source for over 70% of oral cancers in India Aims/Objectives: An epidemiological survey was conducted in the population of Bhopal city to estimate the prevalence of potentially malignant disorder of the oral cavity. Results: Our study comprised of total 2509 samples out of which males were 1354 (54%) and

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Mijoska, Aneta, Gordana Kovacevska, and Georgi Tomov. "ORAL TISSUE CONDITION IN PROSTHODONTIC GERIATRIC PATIENTS." Teacher of the future 31, no. 4 (2019): 865–68. http://dx.doi.org/10.35120/kij3104865m.

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The world population is continuously getting older in developed and undeveloped countries. According to WHO over 20% of the population in Europe is over 65 years old. Geriatric population in North Macedonia is presented with 16% and with high prevalence of anodontia over 45, 1%, poor oral hygiene and urgent demand of prosthodontics treatment. Aging is a process with different and specific changes of all systems and organs, including the orophacial system. In this population, the number of remaining teeth is evidently reduced, their condition has changed, and soft and hard oral tissues are affe

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Sadat, S. M. Anwar, Fariha Tajin, Nowrin Jahan Nishi, and Naimul Islam. "Management of Oral Leukoplakia: A Review." Journal of Bangladesh College of Physicians and Surgeons 41, no. 2 (2023): 156–63. http://dx.doi.org/10.3329/jbcps.v41i2.64506.

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Oral leukoplakia is a widely known white oral mucosal lesion which is encountered by dental practitioners specially by oral and maxillofacial surgeons in daily practice. The objective of this article is to update the reader on the concept of treatment algorithm for the management of leukoplakia. Articles were searched through PubMed, Google Scholar and the Cochrane Library (2017 to 2021), confining search to English language with the key words e.g., leukoplakia, white patch, precancerous lesion, premalignant lesion and oral potentially malignant disorders. After initial collection of abstracts

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Ayala, Alberto G., and Jae Y. Ro. "Prostatic Intraepithelial Neoplasia: Recent Advances." Archives of Pathology & Laboratory Medicine 131, no. 8 (2007): 1257–66. http://dx.doi.org/10.5858/2007-131-1257-pinra.

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Abstract Context.—There have been 2 putative prostatic cancer precursors, prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia (adenosis), but PIN remains as a well-known precancerous condition. Objective.—To describe recent advances in knowledge of PIN and to better define the diagnostic criteria and differential diagnosis of PIN. Data Sources.—Review of the pertinent literature and our experience. Conclusions.—The presence of ductal/acinar epithelial changes including nuclear enlargement, prominent nucleoli, chromatin alterations, and luminal complexity is an easy w

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Sarkar, Rupam. "Journey from Oral Sub mucous Fibrosis (Osmf) to Functional Disease-Free Mouth Opening." Journal of Health Physiotherapy and Orthopaedics 1, no. 1 (2024): 22–27. https://doi.org/10.55522/jhpo.v1i1.0008.

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Oral Submucous Fibrosis (OSMF) is a potentially malignant disease that causes oral mucosa damage. It is a well-known chronic insidious disease, precancerous condition, an autoimmune and collagen-related disorder with a multifactorial cause associated with betel quid chewing and characterized by gradual hyalinization of the lamina propria. In the large literature available for OSMF, multiple staging systems have already been proposed by various authors. Some of the most essential staging systems are widely utilized in clinical practice, resulting in earlier diagnosis and treatment. The treatmen

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Yu, Chuan-Hang, Chih-Yuan Fang, Cheng-Chia Yu, et al. "LINC00312/YBX1 Axis Regulates Myofibroblast Activities in Oral Submucous Fibrosis." International Journal of Molecular Sciences 21, no. 8 (2020): 2979. http://dx.doi.org/10.3390/ijms21082979.

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Oral submucous fibrosis (OSF) has been recognized as a precancerous disorder in the oral cavity. Great effort has been made to inhibit the malignant progression of OSF over the past decades, but the cure of this fibrosis disease has not been discovered. In the present study, we found that a long noncoding RNA, LINC00312, was upregulated in OSF tissues, and positively associated with several fibrosis factors, such as α-SMA, type I collagen, and fibronectin. As such, we sought to investigate the role of LINC00312 in OSF progression and identify its interacting factor that mediated oral fibrogene

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Guttieri, Luisa, Salvatore Raffa, Gerardo Salerno, et al. "FGFR2c Upregulation Contributes to Cancer-Associated Fibroblast Program Activation and to Enhanced Autophagy in Actinic Keratosis-Derived Dermal Fibroblasts: A Possible Role in Precancerous Cell/Stromal Cell Crosstalk." Biology 12, no. 3 (2023): 463. http://dx.doi.org/10.3390/biology12030463.

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Actinic keratosis (AK) is a preneoplastic skin disorder which can rapidly progress to cutaneous squamous cell carcinomas (SCCs). In light of our previous findings, indicating a possible oncogenic role of the mesenchymal isoform of FGFR2 (FGFR2c) aberrantly expressed in AK keratinocytes, we analyzed the possible tumor-promoting role of this receptor in the stromal AK counterpart in this work. Molecular analysis showed that, particularly in early AK lesions, FGFR2c dermal upregulation is accompanied by the downregulation of the cancer-associated fibroblasts (CAF) transcription repressor CSL, the

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Zheng, Weiyang, Ke Pang, Yiyang Min, and Dong Wu. "Prospect and Challenges of Volatile Organic Compound Breath Testing in Non-Cancer Gastrointestinal Disorders." Biomedicines 12, no. 8 (2024): 1815. http://dx.doi.org/10.3390/biomedicines12081815.

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Breath analysis, despite being an overlooked biomatrix, has a rich history in disease diagnosis. However, volatile organic compounds (VOCs) have yet to establish themselves as clinically validated biomarkers for specific diseases. As focusing solely on late-stage or malignant disease biomarkers may have limited relevance in clinical practice, the objective of this review is to explore the potential of VOC breath tests for the diagnosis of non-cancer diseases: (1) Precancerous conditions like gastro-esophageal reflux disease (GERD) and Barrett’s esophagus (BE), where breath tests can complement

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Paul, Joan, Alicia T. Dagrosa, Youdinghuan Chen, Pamela Gangar, Daniel Ressler та M. Shane Chapman. "Photodynamic Therapy with δ-Aminolevulinic Acid and Blue Light for the Treatment of Actinic Cheilitis". SKIN The Journal of Cutaneous Medicine 4, № 4 (2020): 357–60. http://dx.doi.org/10.25251/skin.4.4.14.

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ABSTRACTBackground: Actinic cheilitis is a common precancerous disorder of the lower lip caused by ultraviolet radiation. Photodynamic therapy (PDT) is a potential treatment for actinic cheilitis, however controlled clinical trials regarding this treatment are needed.Objective: To evaluate the safety and efficacy of PDT with blue light and topical δ-aminolevulinic acid (Levulan®) in the treatment of actinic cheilitis.Methods: We conducted a single center, investigator-initiated, nonrandomized, open-label, proof of concept study of PDT with blue light for the treatment of actinic cheilitis. We

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Lin, Cindy (Hsin-Ti), Benjamin Liu, Hannah Hill, et al. "Comparative risk of obesity-related cancer with glucagon-like protein-1 receptor agonists vs. bariatric surgery in patients with BMI ≥ 35." Journal of Clinical Oncology 42, no. 16_suppl (2024): 10508. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.10508.

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10508 Background: Bariatric surgery is suggested to reduce the risk of obesity-related cancers, prompting us to explore whether glucagon-like peptide-1 receptor agonist (GLP-1 RA) offers a similar association. Methods: We queried TriNetX, a global healthcare database to identify patients with BMI of ≥ 35. Three pair-wise propensity score-matched (PSM) comparisons were created: 1) GLP-1 RA vs. Bariatric Surgery, 2) GLP-1 RA vs. No Intervention, 3) Bariatric Surgery vs. No Intervention. Cohorts were exclusive and no intervention was defined as an ambulatory visit. Patients required a minimum of

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Sevlani, Sonia T., Sheetal Gondkar, and Ravindranath Saudagar. "A REVIEW Oral Sub Mucous Fibrosis: A Review." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 712–15. http://dx.doi.org/10.22270/jddt.v9i3.2898.

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Oral Sub Mucous Fibrosis is a well- recognized clinical entity, known since the time of Sushruta. In the modern literature OSMF was first reported by Schwartz (1952), Joshi (1953) was the first person to describe this entity in India. Oral Sub Mucous Fibrosis (OSMF) is a potentially malignant disease that results in progressive juxtaepithelial fibrosis of the oral soft tissues, resulting in increasing loss of tissue mobility, marked rigidity and an eventual inability to open the mouth. The basic change is a fibroelastic transformation of the connective tissue in the lamina propria followed by

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Agha-Hosseini, Farzaneh, Nafiseh Sheykhbahaei, and Maryam-Sadat SadrZadeh-Afshar. "Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review." Journal of Contemporary Dental Practice 17, no. 8 (2016): 692–701. http://dx.doi.org/10.5005/jp-journals-10024-1914.

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ABSTRACT Aim Many studies have suggested that a lesion originally diagnosed as oral lichen planus (OLP) has different possibilities of undergoing malignant transformation in time, although these findings remain a controversial issue; for example, some studies reported different values of potential malignancy of OLP. Introduction World Health Organization (WHO) classifies OLP as a “potentially malignant disorder” with unspecified malignant transformation risk, and suggests that OLP patients should be closely monitored. Numerous studies have attempted to confirm the malignant transformation pote

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Nouraddini, Nazanin, and Giorgi Dugashvili. "Oral Microbiome and Its Role in Oral Lichen Planus Development: A Literature Review." European Scientific Journal, ESJ 21, no. 39 (2025): 30. https://doi.org/10.19044/esj.2025.v21n39p30.

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This article aims to explore the oral microbiome, the implications of its dysbiosis and its role in the development of oral lichen planus (OLP) and systemic diseases. This underscores the necessity for additional research to elucidate the connections between oral microorganisms and the pathology of OLP. Furthermore, a deeper understanding of these intricate interactions may pave the way for novel therapeutic strategies and improved disease management. An electronic search was conducted using PubMed and Scopus, complemented by a manual review of the reference lists of the identified articles fo

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Christie-Nguyen, P., J. Tschen, and B. mai. "Exploring Epidermodysplasia Verruciformis: A Case Report, Treatment Strategies, and Emerging Therapies." American Journal of Clinical Pathology 162, Supplement_1 (2024): S29. http://dx.doi.org/10.1093/ajcp/aqae129.063.

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Abstract Introduction/Objective Epidermodysplasia verruciformis (EV) is a rare cutaneous disorder with both inherited and acquired forms. Inherited cases involve mutations in genes such as ERV1 and ERV2, crucial for HPV immunity, while acquired cases affect immunocompromised individuals. EV is linked to cutaneous squamous cell carcinoma (SCC), highlighting the need for prompt diagnosis and treatment. Methods/Case Report A 54-year-old HIV-positive man was referred with a persistent, itchy eruption on his forearms despite given ARV regimen, oral retinoids and topical therapies. Physical examinat

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Liu, Yu-Xin, Cheng-Li Bin, Lu Zhang, Wen-Tao Yang, and Bai-Ping An. "Socioeconomic traits and the risk of Barrett’s esophagus and gastroesophageal reflux disease: A Mendelian randomization study." World Journal of Gastrointestinal Oncology 16, no. 6 (2024): 2631–45. http://dx.doi.org/10.4251/wjgo.v16.i6.2631.

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BACKGROUND Previous observational studies have shown that the prevalence of gastroesophageal reflux disease (GERD) and Barrett’s esophagus (BE) is associated with socioeconomic status. However, due to the methodological limitations of traditional observational studies, it is challenging to definitively establish causality. AIM To explore the causal relationship between the prevalence of these conditions and socioeconomic status using Mendelian randomization (MR). METHODS We initially screened single nucleotide polymorphisms (SNPs) to serve as proxies for eight socioeconomic status phenotypes f

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Darjani, Abbas, Zahra Mohtasham-Amiri, Kiarash Mohammad Amini, Javad Golchai, Shahryar Sadre-Eshkevari, and Narges Alizade. "Skin Disorders among Elder Patients in a Referral Center in Northern Iran (2011)." Dermatology Research and Practice 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/193205.

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Background. Geriatric health care has become a worldwide concern, but a few statistical studies were carried out about skin diseases in this age group. In this study, we set out to determine the frequency as well as the age and gender distribution of dermatological diseases in geriatric patients.Materials and Methods. In a cross-sectional study, all patients over 60 years who were accepted to department of dermatology in north of Iran participated in this study. Baseline information and clinical examination were done by a group of dermatologists. Biopsy, Pathological and laboratory methods wer

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Rakheerathnam, K. K., K. Ranganathan та S. Niranjali Devaraj. "Cross-talk of TGF-β and Wnt/β-Catenin Pathways Leading to Epithelial Mesenchymal Transition in Oral Submucous Fibrosis in Indian Population". Journal of Global Oncology 4, Supplement 2 (2018): 203s. http://dx.doi.org/10.1200/jgo.18.82100.

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Background: Oral squamous cell carcinoma (OSCC) is a predominant type of cancer in India. It has been observed that OSSC is preceded by premalignant lesions or otherwise reported as potentially malignant disorders (PMD) by WHO during the year 2005. PMD include various oral mucosal diseases such as leukoplakia, erythroplakia, oral submucous fibrosis (OSMF), oral lichen planus, discoid lupus erythematosus and actinic keratosis etc. Literature surveys have highlighted that areca nut–associated oral squamous cell carcinoma is the third most common malignancy in the developing world and OSMF has be

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Shen, Jie, Pei Li, Shuangshuang Liu, et al. "The chemopreventive effects of Huangqin-tea against AOM-induced preneoplastic colonic aberrant crypt foci in rats and omics analysis." Food & Function 11, no. 11 (2020): 9634–50. http://dx.doi.org/10.1039/d0fo01731k.

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Sasmal, Nabarun, Rashmi Mukherjee, Dilip Kr. Nandi, and Surajit Bose. "BIOCHEMICAL METABOLITE PROFILING IN ORAL POTENTIALLY MALIGNANT DISORDERS: A DIAGNOSTIC AND PROGNOSTIC APPROACH." International Journal of Advanced Research 13 (February 28, 2025): 127–34. https://doi.org/10.21474/ijar01/20360.

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Cancer is characterised by the uncontrolled cell growth that disrupt surrounding tissues. Oral cancer (OC) typically starts as a tiny, unexplained growth or lesion of oral cavityextending to the oropharynx. Alterations in antioxidant defence, whether through an increase or decrease, can damage macromolecules, including proteins and other biochemical metabolites. Thus, protein, lipid profile and other biochemical metabolites can be potential biomarkers in oral premalignant. This research aims to determine and compare the levels of serum proteins, Lipid profile, urea, uric acid, and other metabo

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Ognerubov, Nikolai A. "Facial nerve lesion as a complication of cryodestruction for facial basal cell carcinoma." Consilium Medicum 23, no. 11 (2021): 891–96. http://dx.doi.org/10.26442/20751753.2021.11.201251.

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Background. Skin cancer is the most common malignant neoplasm which represents an important problem for modern health care. Published data show that the incidence is increasing over the past 50 years; by 310% annually. The prevalence of skin cancer depends on a number of factors: genetic, environmental influences, age, profession. Treatment options for basal cell skin cancer include surgery, radiation therapy, photodynamic therapy, local chemotherapy and immunotherapy, radio wave therapy, cryosurgery, laser therapy, and targeted therapy. Among them, cryosurgery is an effective, technically sim

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Misbahul, Haque. "Pre- and Post-Treatment Comparison of Intralesional Dexamethasone and Hyaluronidase for Managing Oral Submucous Fibrosis (OSMF)." International Journal of Pharmaceutical and Clinical Research 16, no. 11 (2024): 2002–6. https://doi.org/10.5281/zenodo.14637495.

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<strong>Background:</strong> (OSMF) is a chronic, progressive disorder of the oral mucosa, characterized by fibrosis of the submucosal tissues, leading to restricted mouth opening, pain, and difficulty in oral functions. The condition is considered a precancerous lesion with a significant risk of malignant transformation, particularly in regions with high betel nut chewing prevalence. Despite its high prevalence, the management of OSMF remains challenging, with limited success from conservative therapies. <strong>Aim:</strong> This study aimed to evaluate the efficacy of intrale

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Nishinaka-Arai, Yoko, Yohko Kitagawa, Yasuhiro Kazuki, et al. "Elucidation of the Unique Function of GATA1s in the Development of Transient Abnormal Myeloproliferative Disorders." Blood 142, Supplement 1 (2023): 4121. http://dx.doi.org/10.1182/blood-2023-179017.

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Transient abnormal myeloproliferative disorder (TAM) is a pre-leukemic condition that occurs at birth in children with Down syndrome. The responsible gene of TAM, GATA1, is a hematopoietic transcription factor integral to hematopoiesis. The GATA1 gene has two translation start sites, giving rise to two protein variants: GATA1-fl, a full-length protein, and GATA1s, an isoform lacking the N-terminal domain. Notably, TAM blasts express only the GATA1s due to a mutation in the GATA1 gene, as opposed to normal cells which express both proteins. This implies that the precancerous state is not trigge

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Lipne, Dr.Namrata, Dr.Archana Kulkarni, and Dr.Apurva Pathak. "Pap Smear as a Diagnostic Tool for Gynecological Disorders in the Context of Yoni Vyapad: A Literature Review." International Journal of Diagnostics And Research 2, no. 2 (2025): 19–24. https://doi.org/10.5281/zenodo.14650002.

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The Pap smear is a vital diagnostic tool in modern gynaecology, widely recognized for its role in detecting cervical abnormalities, infections, and precancerous lesions. This test involves the collection of cells from the cervix to identify precancerous and cancerous processes. It is a vital component in the prevention of cervical cancer, enabling early detection and treatment of abnormal cell changes before they progress to cancer. In Ayurveda various gynaecological disorders explained under the term Yoni Vyapad, encompassing structural, functional, and infectious conditions caused by Dosha i

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Kokane, Gauri, Viraj Kharkar, Harjit Kalsi, et al. "Quantum leap in the diagnosis of oral potentially malignant disorders – A review of literature." National Journal of Maxillofacial Surgery 15, no. 3 (2024): 360–66. http://dx.doi.org/10.4103/njms.njms_132_23.

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Early diagnosis of oral potentially malignant disorders (OPMDs) can bring about considerable improvement in reducing the statistics related to morbidity and mortality associated with oral cancer. The objective of this review was to summarize advanced diagnostic aids used for OPMDs. Pubmed, Embase, and Cochrane Central Register of Controlled Trials electronic databases from 1969 to 2022 focus on advanced diagnostic techniques for potentially malignant disorders. An electronic database was searched for keywords: “Potentially malignant disorders”, “Early diagnostic aids”, advanced diagnostic aids

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Harris, Ashlee, and Thomas Andl. "Precancerous Lesions of the Head and Neck Region and Their Stromal Aberrations: Piecemeal Data." Cancers 15, no. 8 (2023): 2192. http://dx.doi.org/10.3390/cancers15082192.

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Head and neck squamous cell carcinomas (HNSCCs) develop through a series of precancerous stages from a pool of potentially malignant disorders (PMDs). Although we understand the genetic changes that lead to HNSCC, our understanding of the role of the stroma in the progression from precancer to cancer is limited. The stroma is the primary battleground between the forces that prevent and promote cancer growth. Targeting the stroma has yielded promising cancer therapies. However, the stroma at the precancerous stage of HNSCCs is poorly defined, and we may miss opportunities for chemopreventive in

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Ambounda Ledaga, Nathalie, Sylvain Honore Woromogo, Felicite Emma Yagata-Moussa, Audin Serge Mavoungou, and Vicky Noel Simo Tekem. "Cervical precancerous lesions at the Tchibanga Regional Hospital and the University Hospital in Gabon in 2018: smartphone as a screening tool for diagnosis." African Health Sciences 22, no. 1 (2022): 92–7. http://dx.doi.org/10.4314/ahs.v22i1.12.

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Background: Cervical precancerous lesions are disorders that can induce discolouration changes. Their detection is difficult in remote areas in the absence of adequate equipment. The objectives were to evaluate Smartphone performance in diagnosing cervical precancerous lesions in Tchibanga, Gabon. Methods: It was an interventional cross-sectional study to evaluate the validity and reliability of the smartphone as a tool for diagnosing atypical changes in the cervix. Study period was between July 1, 2017 to February 28, 2018 at the Tchibanga Regional Hospital (CHRT) and the University Hos

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Memè, Lucia, Pierluigi Marotti, Valeria Colonna, et al. "Emphasizing HPV infection and the molecular processes in oral cancer development." Oral & Implantology 16, no. 3.1suppl (2024): 218–31. https://doi.org/10.11138/oi163.1suppl218-231.

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This research examines the epidemiological features and biomolecular mechanisms contributing to developing precancerous and cancerous conditions in oral lesions associated with Human Papillomavirus (HPV) infections. Existing literature highlights HPV's role in potentially malignant oral disorders. Consequently, the underlying biomolecular processes can initiate or contribute to benign lesions and oral carcinogenesis.

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Chole, Revant H., and Swati Balsaraf. "Prevention and control of oral potentially malignant disorders." International Journal of Oral Health Sciences 14, no. 2 (2024): 45–48. https://doi.org/10.4103/ijohs.ijohs_8_24.

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Abstract Oral cavity cancer accounts for approximately 4% of all malignancies and is a significant worldwide health problem. In Southeast Asia, oral cancer account for 40% of all cancers. It is the consensus of health promotion researchers that culturally specific (CS) interventions are important in addressing smoking-related health disparities. Equivocal evidence also exists for tobacco interventions that do not attend to culture specific characteristics, that is, traditional or non-CS interventions. Tobacco use is one of the major public health problems in the world, resulting in 5.4 million

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Santacroce, Luigi, Michele Di Cosola, Lucrezia Bottalico, et al. "Focus on HPV Infection and the Molecular Mechanisms of Oral Carcinogenesis." Viruses 13, no. 4 (2021): 559. http://dx.doi.org/10.3390/v13040559.

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This study is focused on the epidemiological characteristics and biomolecular mechanisms that lead to the development of precancerous and cancerous conditions of oral lesions related to Human Papilloma Virus (HPV) infections. Current evidence from the literature demonstrates the role of HPV in potentially malignant oral disorders. Therefore, the underlying biomolecular processes can give arise, or contribute to, benign lesions as well as to oral carcinogenesis.

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Riebesehl, Bea, Lea S. Beensen, Felix Bormann, et al. "Abstract 208: Epigenomic characterization of keratinocyte carcinomas in xeroderma pigmentosum." Cancer Research 85, no. 8_Supplement_1 (2025): 208–108. https://doi.org/10.1158/1538-7445.am2025-208.

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Keratinocyte carcinomas (KCs), comprising basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), arise in the epidermis due to chronic exposure to solar ultraviolet (UV) radiation. KCs account for 99% of skin neoplasms and represent the most prevalent form of cancer worldwide. DNA methylation, an epigenetic modification of CpG dinucleotides, modulates gene expression, thereby defining cell identity and mediating cellular responses to external stimuli. Aging and environmental stressors, including UV radiation, progressively alter epidermal methylomes, thus influencing KC devel

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