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Relevant bibliographies by topics / Precision health / Dissertations / Theses

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Dissertations / Theses on the topic 'Precision health'

Author: Grafiati

Published: 22 March 2025

Last updated: 25 July 2025

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1

Sloan-Heggen, Christina Marie. "Precision health and deafness–optimizing genetic diagnosis." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6287.

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Deafness is the most common sensory deficit in humans. In the United States 1-2 in a thousand babies is born with significant deafness, well over half of which is hereditary. Providing a patient and their family with a genetic diagnosis is the ultimate form of precision health and medicine; it can provide education, impact medical testing and treatment, provide peace of mind, and someday will be the key to providing gene specific therapies. Historically, providing this diagnosis was difficult, expensive, and time consuming due to the extreme clinical and genetic heterogeneity of non-syndromic

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2

Manrai, Arjun Kumar. "Statistical foundations for precision medicine." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/97826.

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Thesis: Ph. D., Harvard-MIT Program in Health Sciences and Technology, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Physicians must often diagnose their patients using disease archetypes that are based on symptoms as opposed to underlying pathophysiology. The growing concept of "precision medicine" addresses this challenge by recognizing the vast yet fractured state of biomedical data, and calls for a patient-centered view of data in which molecular, clinical, and environmental measurements are stored in large shareable databases. Such efforts have

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Eliot, Trevor G. "Provider precision labs healthcare analytics and decision support." Thesis, California State University, Long Beach, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10111177.

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<p> The healthcare industry is undergoing a shift due to changes in revenue cycles and therefore delivery models. This shift is causing horizontal integration among providers and a subsequent assumption of risk that behooves them to operate similar to a payer. Analytics, while used predominately by healthcare payers in the past, will now be applicable to providers of care. This opens the door to a niche consulting firm that can provide these services effectively and affordably. Provider Precision Labs is an idea for a company that can render payer-like services on the scale of regional provide

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4

GALASSO, ILARIA. "PRECISION MEDICINE IN SOCIETY: PROMISES, EXPECTATIONS AND CONCERNS AROUND SOCIAL AND HEALTH EQUITY." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/609264.

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This thesis analyzes precision medicine from an ethical and political perspective, especially in terms of distributive justice: it is aimed at investigating the kinds of benefits that can be produced after precision medicine, and the possible distributions of those benefits, by considering the consequent impact of precision medicine on social and health equity. Precision medicine is considered as a social construct subjected to different interpretations, and it is analyzed by mainly referring to two major case studies: the Precision Medicine Initiative in the US, and the 100,000 Genomes

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Arnold, Matthias [Verfasser]. "Linking Precision Medicine to Public Health: An Economic Perspective on Mammography Screening / Matthias Arnold." München : Verlag Dr. Hut, 2018. http://d-nb.info/1168534283/34.

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Mukwaya, Jovia Namugerwa. "An Investigation of Semantic Interoperability with EHR systems for Precision Dosing." Thesis, KTH, Medicinteknik och hälsosystem, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-279143.

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In healthcare, vulnerable populations that are using medications with a narrow therapeutic index and wide interpatient PK/PD (pharmacokinetic/pharmacodynamic modelling) variability are increasing. As such, variable dosage regimens may result in severe therapeutic failures or adverse drug reactions (ADR). Improved monitoring of patient response to medication and personalization of treatment is therefore warranted. Precision dosing aims to individualize drug regimens for each patient based on independent factors obtained from a patient’s clinical records. Personalization of dosing increases the

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7

Picard, Yani. "Improving the precision and accuracy of Monte Carlo simulation in positron emission tomography." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68241.

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PETSIM, a Monte Carlo simulation program of Positron Emission Tomography (PET) systems, was improved in terms of accuracy and efficiency. First, the accuracy, the speed and the ease of use of PETSIM were improved by using tabulated values of the Compton scattering and photoelectric absorption partial interaction attenuation coefficients for all common biological, collimator and detector materials. These were generated from chemical formula, or physical composition, and density of the absorbing medium.<br>Furthermore, simulations of PET systems waste considerable time generating events which wi

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8

Krieger, Glenn. "Cephalometric regional superimpositions -- digital vs. analog accuracy and precision : 1. the maxilla." Thesis, NSUWorks, 2014. https://nsuworks.nova.edu/hpd_cdm_stuetd/58.

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Introduction: The purpose of this study was to measure the displacement of defined dental structures, as a result of superimposition of cephalometric images across paired time-points by both digital and analog methods. The magnitudes of such displacements across three methods of superimposition were compared to each other and to a reference method constructed by registering superimposed cephalometric images on tantalum markers implanted in the study participants' maxillae. The defined dental structures were: 1) First molar mesial contact point; 2) First molar apical root bisection; 3) Central

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9

Buran, Bradley N. (Bradley Nicholas). "Precision and reliability of cochlear nerve response in mice lacking functional synaptic ribbons." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/54454.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2009.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 87-99).<br>Synaptic ribbons are electron-dense structures surrounded by vesicles and anchored to the presynaptic membrane of photoreceptors, retinal bipolar cells and hair cells. Ribbon synapses are characterized by sustained exocytosis that is graded with stimulus intensity and can achieve high release rates. Leading hypotheses implicate the ribbon in maintenance of a large readily releasable pool (RRP) of presynaptic vesicles which

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McCaffrey, Kevin. "Cephalometric regional superimpositions -- digital vs. analog accuracy and precision: 2. the mandible." Thesis, NSUWorks, 2014. https://nsuworks.nova.edu/hpd_cdm_stuetd/19.

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Introduction: Lateral cephalometric superimpositions (LCS) are used to measure dental and skeletal changes that occur in the craniofacial complex over time. Orthodontists use LCSs to assess treatment outcomes. The purpose of this study was to conduct an assessment of the measured displacement of defined dental landmarks across digital and analog methods of mandibular regional serial superimposition as compared to an implant-registered superimposition reference. The data used in this study was derived from the Mathew's Acquisition Group implant sample; the first United States longitudinal study

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Chunara, Rumi. "Electronic readout of microchannel resonators for precision mass sensing in solution by Rumi Chunara." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57803.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 115-120).<br>Microfabricated transducers have enabled new approaches for detection of biomolecules and cells. Integration of electronics with these tools simplify systems and provide platforms for robust use outside of the laboratory setting. Suspended microchannel resonators (SMRs) are sensitive microfluidic platforms used to precisely measure the buoyant mass of single cells and monolayers of protein in fluid environments. Conventi

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12

Sinha, Vikram Paritosh 1969. "Prediction of in vivo hepatic clearance of selected compounds using the isolated perfused rat liver, precision-cut liver slices and hepatocytes." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/282203.

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The overall objective of this dissertation was to estimate the in vivo hepatic clearance (CL(H)) of compounds using in vitro methods of drug metabolism. The isolated perfused rat liver, precision-cut liver slices and hepatocyte were used to estimate in vitro CL(H) and compared to in vivo CL(H) Two compounds, benzoic acid and tolbutamide were chosen as model compounds. An isolated perfused rat liver (IPRL) apparatus was developed to measure hepatic extraction ratio. Three compounds, antipyrine, ethanol and lidocaine were used to characterize the apparatus. The ability of the IPRL to utilize oxy

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Mazumdar, Sohinee. "Geographic information systems in the application of precision agriculture for sustainable sugarcane production in the Republic of Panama." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18772.

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Geographic Information Systems (GIS) have revolutionized the development of the sophisticated resource management method known as Precision Agriculture (PA). PA involves the wise management of agricultural inputs based on knowledge of soil and plant health heterogeneity over a field, in order to minimize environmental impact and increase economic efficiency. A GIS platform was created as the basis of PA implementation at Azucarera Nacional sugarcane plantation in Panama. Field data collection took place over two years, from 2005 to 2006. A digital map of Mangote plantation was created and link

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Shaw, Douglas. "Cephalometric regional superimpositions -- digital vs. analog accuracy and precision : 3. the cranial base." Thesis, NSUWorks, 2014. https://nsuworks.nova.edu/hpd_cdm_stuetd/18.

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Objective. To assess the accuracy and precision in measurement of pairwise implant displacement across three methods of cranial base superimposition. Background. Cephalometric superimposition is the principal radiographic method used to evaluate changes within the craniofacial skeleton. Many studies have examined the accuracy of software intended to produce cephalometric superimposition. Such studies have utilized anatomic landmarks, selected by the respective software manufacturers, as registration points for constructing superimpositions and their analysis. As a result, these studies are onl

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Gashi, Tomor, and Eddie Larsson. "A standardized method for evaluating trueness and precision of intraoral scanners – in vitro accuracy." Thesis, Malmö högskola, Odontologiska fakulteten (OD), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19925.

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Bakgrund. En gyllene standard för att bestämma noggrannheten för intraorala scannrarexisterar inte. Intraorala scannrars prestanda som ges av olika leverantörer är inte fulltjämförbara. Det finns ett behov att standardisera och ta fram oberoende försöksupplägg för att kunna jämföra intraorala scannrar.Mål. Målet med studien var att beskriva och utvärdera en ny metod för att bestämmanoggrannheten av intraorala scannrar genom ett standardiserat in vitro testförsök och attanvända metoden för att beräkna noggrannheten på en kommersiell intraoral scanner.Material och metod. SP Sveriges tekniska for

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Coholic, Alexander, and Fanny Hellberg. "Reliability and precision of root length measurements in cone beam CT images: a study of adolescents." Thesis, Malmö universitet, Odontologiska fakulteten (OD), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19758.

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Bakgrund: Under en ortodontisk behandling med fast apparatur finns det en risk för att tänderna drabbas av rotresorption. Rotresorptioner kan mätas med hjälp av Cone Beam Computed Tomography (CBCT). Mätresultatet kan dock variera mellan olika observatörer och mätfel kan uppstå vilket påverkar metodens tillförlitlighet.Syfte: Att beräkna det mätfel som uppstår vid mätning av rotresorptioner som uppstår till följd av en ortodontisk behandling i CBCT-bilder och utvärdera mätmetodens tillförlitlighet. Metod: Tio ungdomar som genomgick ortodontisk behandling undersöktes med hjälp av CBCT-röntgen

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Lyttkens, Peter. "Epidemiologiska modeller för herpesvirusets roll i kognitiv svikt." Thesis, Uppsala universitet, Folkhälsovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447420.

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Introduction: Cognitive impairment is converted for 15% to Alzheimer’s disease (AD), which is incurable. The aim of this study is to investigate whether Herpes simplex virus type 1 (HSV1) and its interaction with allele ε4 of Apolipoprotein E (ApoE-ε4) may be possible risk factors for cognitive impairment. Here, suggestions for implementation of Precision Public Health (PPH) is also presented; population studies of relevant biomarkers of infectious burden and data from health outcomes with the aim of remedying public health crises, monitoring diseases, anticipating risks and using public healt

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Fernandez, Shane. "A multi-method approach to exploring the role of genetics in explaining cognitive decline heterogeneity across the Alzheimer's disease spectrum." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2025. https://ro.ecu.edu.au/theses/2899.

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Cognitive decline is a fundamental measure of Alzheimer’s disease progression. However, individual variation in rates of change is widely reported. Genetics may contribute to this, but prior studies have struggled to replicate findings, possibly due to inconsistent cognitive measures as well as methodological limitations. To address this, traditional and novel modelling approaches were compared in exploring how genetic factors may affect rates of decline in five cognitive domains. Results show that accounting for non-linear effects of impairment improves detection of genetic signals in cogniti

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Crabtree, Brian, J. Lyle Bootman, Cynthia J. Boyle, Patricia Chase, Peggy Piascik, and Lucinda L. Maine. "Aligning the AACP Strategic Engagement Agenda with Key Federal Priorities in Health: Report of the 2016-17 Argus Commission." AMER ASSOC COLL PHARMACY, 2017. http://hdl.handle.net/10150/626251.

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The Argus Commission identified three major federal priorities related to health care, including the precision medicine initiative, the Cancer Moonshot and the opioid abuse epidemic. Current activities at the federal level were summarized and an analysis of activities within the profession, and academic pharmacy specifically, was prepared. The implications for pharmacy education, research and practice are compelling in all three areas. Recommendations, suggestions and two policy statements aim to optimize the attention to these priorities by the academy. Further, aligning the AACP Strategic En

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Mohammad, Ammad Uddin. "UAV Routing Protocol (URP) for crop health management." Thesis, Brest, 2017. http://www.theses.fr/2017BRES0147/document.

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Les réseaux de capteurs sans fil sont maintenant un moyen crédible de collecte de données sur les cultures. L'installation d'une structure de communication fixe pour relayer les données surveillées depuis la tête de grappe jusqu'à sa destination finale peut être soit impraticable en raison de la topologie du terrain, soit prohibitive en raison du coût initial élevé. Une solution plausible consiste à utiliser des véhicules aériens sans pilote (UAV) comme moyen alternatif de collecte de données et de contrôle de supervision limité de l'état des détecteurs. Dans cet article, nous considérons le c

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Jensen, Anne. "The accuracy and precision of kinesiology-style manual muscle testing : designing and implementing a series of diagnostic test accuracy studies." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:4fd95394-e812-402e-9195-6c82643eaa15.

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<b>Introduction</b>: Kinesiology-style manual muscle testing (kMMT) is a non-invasive assessment method used by various types of practitioners to detect a wide range of target conditions. It is distinctly different from the muscle testing performed in orthopaedic/neurological settings and from Applied kinesiology. Despite being estimated to be used by over 1 million people worldwide, the usefulness of kMMT has not yet been established. The aim of this thesis was to assess the validity of kMMT by examining its accuracy and precision. <b>Methods</b>: A series of 5 diagnostic test accuracy studie

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Wingqvist, Jenny, and Josephine Lantz. "Utvärdering av IMU-sensorers precision vid mätning av handledens vinkelhastigheter : Jämförande studie med ett optiskt spårningssystem." Thesis, KTH, Medicinteknik och hälsosystem, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-254059.

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Belastningsskador hos arbetare är ett ökande problem hos olika företag och det har visat sig finnas en tydlig koppling mellan dessa skador och handledens vinkelhastigheten. Det är därför av stort intresse att kunna mäta dessa vinkelhastigheter på ett noggrant och smidigt sätt. Syftet med denna rapport är att utvärdera precisionen av IMU-sensorers förmåga att beräkna vinkelhastigheten av handleden. Detta görs genom att jämföra data från IMU-sensorer med data från ett optiskt spårningssystem (OTS), vilket klassas som en gold standard inom detta område. Ett experiment beståe

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Mei, Ying. "Error analysis for distributed fibre optic sensing technology based on Brillouin scattering." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/278660.

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This dissertation describes the work conducted on error analysis for Brillouin Optical Time Domain Reflectometry (BOTDR), a distributed strain sensing technology used for monitoring the structural performance of infrastructures. Although BOTDR has been recently applied to many infrastructure monitoring applications, its measurement error has not yet been thoroughly investigated. The challenge to accurately monitor structures using BOTDR sensors lies in the fact that the measurement error is dependent on the noise and the spatial resolution of the sensor as well as the non-uniformity of the mon

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Unger, Elin, and Sofia Wahlgren. "Artikulatorisk hastighet och precision i stavelseupprepning för patienter med Parkinsons sjukdom: : En postoperativ jämförelse mellan patienter som genomgått Deep Brain Stimulation i Caudal Zona Incerta (cZi) respektive Nucleus Subthalamicus (STN)." Thesis, Umeå universitet, Logopedi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-146254.

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Bakgrund: En förbättring av kroppslig motorik efter Deep Brain Stimulation (DBS) har noterats hos Parkinsonpatienter efter Deep Brain Stimulation (DBS) i Nucleus Subthalamicus (STN) och Caudal Zona Incerta (cZi). Postoperativa effekter för talmotorik och övrig kroppsmotorik skiljer sig dock ofta åt. Försämring av flera talaspekter har rapporterats, inklusive nedsatt artikulatorisk precision. Minskad artikulatorisk precision hos Parkinsonpatienter påverkar produktionen av tonlösa klusiler, såväl som talhastigheten. Detta kan mätas via akustisk analys av diadochokinetiska uppgifter (DDK) i form

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Sawvel, Eric J. "Use Of passive samplers to characterize the spatial heterogeneity of coarse particle mass concentration and composition in Cleveland, OH." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/5053.

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The overall goals of this dissertation are: 1) to better quantify the spatial heterogeneity of coarse particulate matter (PM10-2.5) and its chemical composition; and 2) to evaluate the performance (accuracy and precision) of passive samplers analyzed by computer-controlled scanning electron microscopy with energy-dispersive X-ray spectroscopy (CCSEM-EDS) for PM10-2.5. For these goals, field studies were conducted over multiple seasons in Cleveland, OH and were the source of data for this dissertation. To achieve the first goal, we characterized spatial variability in the mass and composition o

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Iborra, Egea Oriol. "Novel approaches towards precision medicine in acute and chronic heart failure." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669734.

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L’infart de miocardi (IM) és causat per una aturada sobtada del flux de sang que provoca isquèmia local al cor i desencadena un remodelat patològic, que es pot desenvolupar en insuficiència cardíaca (IC). Tot i que pot presentar-se com un esdeveniment estàtic, aquest és un procés complex i dinàmic. En aquesta tesi, es va valorar la IC considerant tot l'espectre de la malaltia. A més, estudis recents donen suport a la idea que processos biològics específics probablement estiguin influïts pel context biològic (p. ex: un teixit específic o una determinada malaltia). Aquesta aproximació constantm

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Gibbons, Deborah Kay. "“It's Not Only About Them:“ Female Family Members' Understanding of Indeterminate Negative BRCA1/2 Test Results." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7701.

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Genetic test results have important implications for close family members. Indeterminate negative results are the most common outcome of BRCA1/2 mutation testing. Little is known about family members' understanding of indeterminate negative BRCA1/2 test results. The purpose of this qualitative descriptive study was to investigate how daughters and sisters received and understood genetic test results as shared by their mothers or sisters. Participants included 81 women aged 40-74 with mothers or sisters previously diagnosed with breast cancer and who received indeterminate negative BRCA1/2 tes

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Jönsson, David, and Mir Kevci. "Geometrical accuracy of metallic objects produced with Additive or Subtractive Manufacturing: a comparative in-vitro study." Thesis, Malmö högskola, Odontologiska fakulteten (OD), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19934.

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Syftet: Utvärdera produktionstolerans av objekt som producerats genom additiv framställningsteknik (AF) för användning inom tandvård, samt att jämföra denna teknik med subtraktiv framställningsteknik (SF) genom reverse engineering.Material och metod: Tio exemplar av två olika geometriska objekt framställdes från fem olika AF maskiner och en SF maskin. Objekt A efterliknar ett inlay, medan objekt B återspeglar en modell av en fyrledsbro. Alla objekt delades in i olika mätled; X, Y och Z. Mätningarna utfördes med validerade och kalibrerade instrument. Linjära avstånd mättes med ett digitalt skju

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Marčišovský, Peter. "Zpracování signálu z akcelerometru na měření vibrací." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2020. http://www.nusl.cz/ntk/nusl-413224.

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Táto diplomová práca sa zaoberá návrhom zariadenia schopného vysoko presného merania vibrácií za použitia piezoelektrického akcelerometra. Zariadenie je určené na vyhodnocovanie zdravotného stavu strojov, najmä elektrických strojov ako elektromotor, veterná turbína a iné. Za účelom dosiahnutia vysoko presného a vysoko lineárneho merania v spektre extrémne nízkych frekvencií siahajúcich až ku jednosmerným napätím, cez sub-hertzové pásma po desiatky hertzov, ale aj vo vyšších frekvenciách, bola vyžadovaná možnosť použitia prístupu s jednosmernou väzbou zvaného "posúvanie napäťovej úrovne" a násl

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Dias, Pedro Carvalhaes 1983. "Um novo sensor de umidade de solo de pulso de calor de alta sensibilidade, baseado em um único transistor bipolar de junção npn = A novel high sensitivity single probe heat pulse soil moisture sensor based on a single npn bipolar junction transistor = A novel high sensitivity single probe heat pulse soil moisture sensor based on a single npn bipolar junction transistor." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/261867.

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Orientador: Elnatan Chagas Ferreira<br>Texto em inglês<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Elétrica e de Computação<br>Made available in DSpace on 2018-08-20T11:54:01Z (GMT). No. of bitstreams: 1 Dias_PedroCarvalhaes_M.pdf: 7362254 bytes, checksum: dd839cf652cbbda17a2a5d9b6cecbdc3 (MD5) Previous issue date: 2012<br>Resumo: A constante preocupação em aumentar a produtividade das plantações de uma forma sustentável e otimizando o uso dos insumos agrícolas (água, fertilizantes, pesticidas e produtos para correção do PH) levou ao desenvolvimento

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DOTTOR, ALBERTO. "MOTOR CONTROL OF THUMB-INDEX SYSTEM IN HEALTHY POPULATION." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1057767.

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Thumb and Index fingers are involved in many daily tasks, it is understandable how injuries, musculoskeletal, rheumatologic, and neurological diseases could affect hand function causing severe disability. The evaluation of motor control deficits of the thumb-index system is necessary to identify impairments and to propose specific therapeutic or surgical proposes. Pinch maximal voluntary contraction is the most investigated parameter, it is a valid estimator of general hand function. However, thumb and index are rarely involved at their maximal contraction, usually they are used in precision

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Morice, Pierre-Marie. "Evaluation de la déficience de la recombinaison homologue et de la réponse des tumeurs ovariennes aux inhibiteurs de PARP grâce à l'utilisation de modèles de culture 3D en vue du développement d'un test prédictif Identifying eligible patients to PARP inhibitors: from NGS-based tests to promising 3D functional assays Automated scoring for assessment of RAD51-mediated homologous recombination in patient-derived tumor organoids of ovarian cancers Risk of myelodysplastic syndrome and acute myeloid leukemia related to PARP inhibitors: a combined approach using a safety meta-analysis of placebo randomized controlled trials and the World Health Organization's pharmacovigilance database The long non-coding RNA ‘UCA1’ modulates the response to chemotherapy of ovarian cancer through direct binding to miR-27a-5p and control of UBE2N levels." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC414.

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Chaque année, plus de 150 000 décès sont associés aux cancers épithéliaux de l’ovaire dans le monde, notamment en raison du développement d’une résistance à la chimiothérapie. Environ la moitié de ces cancers présentent des altérations moléculaires provoquant une déficience de la réparation de l’ADN par recombinaison homologue (HRD) qui les sensibilise à l’action des inhibiteurs de la protéine PARP (PARPi). A ce jour, il n’existe pas de test capable d’appréhender le phénotype HRD dans sa globalité, limitant ainsi l’accès à ces traitements. Dans ce contexte, nous avons entrepris de mettre au po

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Silva, Daniele Fernandes e. "A levels-of-precision approach for physics-based soft tissues modeling." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/119120.

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Simulação computacional de ambientes cirúrgicos têm sido amplamente utilizados, normalmente para treinamentos, ajudando no desenvolvimento de habilidades essenciais e minimizando erros em procedimentos cirúrgicos. Para estes ambientes, é essencial a obtenção de um comportamento mais realista, sendo importante o uso de técnicas com alta precisão, além de uma simulação em tempo real. A fim de melhor controlar este trade-off entre eficiência e eficácia, apresentamos um ambiente híbrido e adaptativo que combina um conjunto de métodos para alcançar uma boa precisão e desempenho na simulação. Nosso

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Grinter, Lori Nicole. "VALIDATION OF AN AUTOMATED BEHAVIOR MONITORING COLLAR, AND EVALUATION OF HEAT STRESS ON LACTATING DAIRY COW BEHAVIOR WITH ACCESS TO A FREE CHOICE SOAKER." UKnowledge, 2019. https://uknowledge.uky.edu/animalsci_etds/101.

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Precision dairy technologies (PDT) are becoming more accessible and are therefore becoming more common on commercial dairy farms and in dairy research. Prior to any use of PDT, one should understand the precision, accuracy and bias of the device by a validations studies before interpreting the behavior measurements. Thus, the objective of the first section of my thesis is to validate ruminating, feeding and resting measurements of a behavior monitoring collar used in the second section. Precision dairy technology is used in heat stress studies to compare behavior of cows exposed to different h

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Kestin, Rebecca (Rebecca Sarah Elmer). "Design and manufacturing of a microcalorimeter for measuring heat flows in electrochemical reactions to milli-Kelvin precision." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119953.

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Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 27-28).<br>Due to their high energy density, lithium-air batteries have tremendous potential for application to batteries for electric vehicles. While significant efforts have been made in understanding the material origins of electrochemical performance under discharging and charging conditions, there is still very limited understanding of the thermodynamics and thermal science, including heat transfer, of such

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Freitas, Marcelle Louise Coelho de. "Evidências de validade e precisão do Teste das Fábulas em escolares." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/59/59137/tde-06102014-213825/.

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Dentre os diversos recursos para avaliação psicológica, os métodos projetivos destacam-se pela riqueza de suas informações a respeito dos componentes e do funcionamento psíquico, nomeadamente na área da investigação de características de personalidade. Para examinar a faixa etária infantil, o Teste de Fábulas (TF) é um dos métodos projetivos disponíveis, baseado na teoria psicanalítica e tem se mostrado relevante e útil, embora com necessidade de revisão de suas evidências psicométricas no contexto brasileiro. O teste consiste em 10 historietas inacabadas que são contadas para a criança, sendo

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Silva, Wilma Madeira da. "Navegar é preciso: avaliação de impactos do uso da internet na relação médico-paciente." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/6/6135/tde-30102006-103313/.

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Objetivos: verificar se indivíduos que acessam a Internet a utilizam para consultar informações sobre saúde e doenças; se o paciente, acessando a Internet muda sua atitude de paciente e se verifica mais ativo e mais participante do processo de decisão sobre sua saúde; e se, do ponto de vista do paciente, houve mudança na atitude do profissional médico frente ao maior uso da Internet por parte desse paciente. Metodologia: pesquisa com abordagem qualiquantitativa. A técnica empregada foi a do Discurso do Sujeito Coletivo DSC, que possibilita a identificação e a construção de sujeitos e discurs

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Massard, Christophe. "Biomarqueurs cellulaires circulants dans les cancers avancés." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-01015618.

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Les biomarqueurs sanguins peuvent être utilisés pour définir le pronostic des patients ou permettre de déterminer les altérations moléculaires des cancers, et peut-être pouvoir guider les traitements de thérapies ciblées.Les cellules tumorales circulantes sont le reflet de la cascade métastatique et de la progression tumorale. La détection et la caractérisation des CTC est un domaine clé de la recherche dans le cancer. Cependant, il n'existe pas de méthode standard pour la détection des CTC, et le premier objectif de notre étude a été de comparer deux systèmes de détection des CTC basé sur l'e

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Brunsch, Reiner, and Cornelia Weltzien. "Gesunde Ernährung, Anforderungen und Potentiale der Rückverfolgbarkeit und Transparenz-Idee der dezentralen Wertschöpfungsketten." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-234777.

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Andrade, Protasio Nery. "Caracterização microestrutural e mecanica de ligas Ti-Cu para aplicações odontologicas." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/263193.

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Orientadores: Rubens Caram Junior, Adelino Aguiar Coelho<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica<br>Made available in DSpace on 2018-08-08T17:54:45Z (GMT). No. of bitstreams: 1 Andrade_ProtasioNery_M.pdf: 9178937 bytes, checksum: f63ed0f47d8aa70b2d3a755e537fbe8f (MD5) Previous issue date: 2006<br>Resumo: Em função de características como alta razão resistência/peso, ótima biocompatibilidade, elevada resistência à corrosão e módulo de elasticidade que pode ser controlado pela adição de elementos de liga, o uso de ligas de titânio pela in

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Анциферова, Олеся Олександрівна. "Технологічне забезпечення точності та якості поверхонь зубчастих коліс при удосконаленні методу зубошліфування". Thesis, НТУ "ХПІ", 2018. http://repository.kpi.kharkov.ua/handle/KhPI-Press/38013.

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Дисертація на здобуття наукового ступеня кандидата технічних наук за спеціальністю 05.02.08 – технологія машинобудування. – Національний технічний університет "Харківський політехнічний інститут", Харків, 2018. Дисертацію присвячено вирішенню проблеми підвищення продуктивності процесу зубошліфування на основі досягнення високої необхідної точності і якості поверхневого шару з оцінкою комплексного впливу конструктивно-технологічних факторів на процес формування поверхневого шару зубів зубчастих коліс з метою підвищення їх зносостійкості, а також продуктивності технологічного процесу в оптимал

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Анциферова, Олеся Олександрівна. "Технологічне забезпечення точності та якості поверхонь зубчастих коліс при удосконаленні методу зубошліфування". Thesis, НТУ "ХПІ", 2018. http://repository.kpi.kharkov.ua/handle/KhPI-Press/37888.

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Дисертація на здобуття наукового ступеня кандидата технічних наук за спеціальністю 05.02.08 – технологія машинобудування. – Національний технічний університет "Харківський політехнічний інститут", Харків, 2018. Дисертацію присвячено вирішенню проблеми підвищення продуктивності процесу зубошліфування на основі досягнення високої необхідної точності і якості поверхневого шару з оцінкою комплексного впливу конструктивно-технологічних факторів на процес формування поверхневого шару зубів зубчастих коліс з метою підвищення їх зносостійкості, а також продуктивності технологічного процесу в оптималь

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van, Rie A., Viedma D. G. de, Conor J. Meehan, et al. "Whole-genome sequencing for TB source investigations: principles of ethical precision public health." 2021. http://hdl.handle.net/10454/18526.

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yes<br>BACKGROUND: Whole-genome sequencing (WGS) of Mycobacterium tuberculosis allows rapid, accurate inferences about the sources, location and timing of transmission. However, in an era of heightened concern for personal privacy and science distrust, such inferences could result in unintended harm and undermine the public´s trust. METHODS: We held interdisciplinary stakeholder discussions and performed ethical analyses of real-world illustrative cases to identify principles that optimise benefit and mitigate harm of M. tuberculosis WGS-driven TB source investigations.RESULTS: The speed and p

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Ferrão, João Luís. "Characterising, modelling and mapping malaria occurrence and its mortality trend for precision public health." Doctoral thesis, 2018. http://hdl.handle.net/10362/64068.

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A thesis submitted in partial fulfillment of the requirements for the degree of Doctor in Information Management Specialization in Statistics and Econometrics<br>This work considers characterizing, modelling and mapping malaria occurrence and its mortality trend for Precision Public Health in Chimoio. Mozambique. Malaria is an ancient disease and a major public concern especially in the African continent. The majority of deaths occur among children living in Africa (91 %), where a child dies every minute and half from malaria. The data for malaria cases and mortality were obtained from the wee

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Cotta, Pedro António Guimarães de Vasconcelos Rebelo. "Precision medicine and schizophrenia: What about telomere length?" Master's thesis, 2019. https://hdl.handle.net/10216/120649.

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Cotta, Pedro António Guimarães de Vasconcelos Rebelo. "Precision medicine and schizophrenia: What about telomere length?" Dissertação, 2019. https://hdl.handle.net/10216/120649.

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Angel, Yoseline. "Monitoring crop development and health using UAV-based hyperspectral imagery and machine learning." Diss., 2021. http://hdl.handle.net/10754/670149.

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Agriculture faces many challenges related to the increasing food demands of a growing global population and the sustainable use of resources in a changing environment. To address them, we need reliable information sources, like exploiting hyperspectral satellite, airborne, and ground-based remote sensing data to observe phenological traits through a crops growth cycle and gather information to precisely diagnose when, why, and where a crop is suffering negative impacts. By combining hyperspectral capabilities with unmanned aerial vehicles (UAVs), there is an increased capacity for provi

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Jackson, Jennie A. "Bias and Precision in Biomechanical Exposure Assessment : Making the Most of our Methods." Doctoral thesis, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-314784.

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Background: Insufficient exposure assessment is a suggested contributing factor to the current lack of clearly characterised relationships between occupational biomechanical risk factors and musculoskeletal disorders. Minimal attention has been paid to the potential bias of measurement tools from expected true values (i.e. accuracy) or between measurement tools, and empirical data on the magnitudes of variance contributed by methodological factors for measurement tool precision are lacking. Aim: The aim of this thesis was to quantify aspects of bias and precision in three commonly employed bio

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Tsai, Pei-Fen, and 蔡佩芬. "The Construction of Precision Healthcare Innovation Service Design Model: An Example from High-end Self-pay Health Management Clinic in Taipei." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/7a3mgd.

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碩士<br>國立臺灣大學<br>健康政策與管理研究所<br>106<br>As the burden of chronic diseases rapidly increases and population demographics shift towards an aging society, healthcare utilization gradually increases in the current year. In addition, with the development of precision medicine, the introduction of personalized healthcare services which meet the needs for individual health expectation will be a key strategy for developing healthcare market and merit further research. However, there is a lack of research on personalized healthcare services, and even fewer studies directly examine innovation management a

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Beato, Frederico Marcelo Rodrigues. "Validation of a predictive model of early tooth loss in periodontitis patients." Master's thesis, 2020. http://hdl.handle.net/10400.26/35387.

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Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz<br>Introduction: Periodontitis is a highly prevalent oral disease characterized by tissue destruction with loss of the dentition’s attachment apparatus and ultimately results in tooth loss, if not treated. Patients with periodontitis and tooth loss see their quality of life greatly impacted. The continuing growth of precision dentistry and prediction modeling approaches to Periodontology aims to excel treatments while minimizing unnecessary costs in what ends up being a more informed and tailored approach, improv

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