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Relevant bibliographies by topics / Precursor-directed in situ synthesis / Dissertations / Theses

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Dissertations / Theses on the topic 'Precursor-directed in situ synthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Shan, Lu. "Studies on saccharothriolides, phenyl-substituted 10-membered macrolides from a rare actinomycete Saccharothrix sp. and precursor-directed in situ synthesis of saccharothriolide analogs." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225540.

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2

Cook, Andrew J. "Design and synthesis of active-site-directed aspartic protease inhibitors." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316902.

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3

Krishna, Prasad Golla. "Synthesis of multicyclic 2-pyridones from a formyl and chlorometylene substituted precursor using a strategy of directed diversity-oriented synthesis." Thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-56763.

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Multi ring-fused 2-pyridones have shown interesting activity in a variety of biological systems. It would be of great interest to explore the biological application of even more multi heterocyclic ring fused 2-pyridones. ‘Diversity oriented synthesis’ is an excellent concept emerged in recent years to access compounds with structurally and stereochemically diverse skeletons. This served as an efficient avenue for synthesizing various ring fused 2-pyridones using formyl, chloromethylene substituted 2-pyridone ( 6) as a starting compound. By treating the starting material (6) with various nucleo

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4

Pereira, Ryan Apolinario. "FUNCTIONAL ANALYSIS OF TWO CONSERVED REGIONS OF ESCHERICHIA COLI ELONGATION FACTOR G AS STUDIED BY SITE-DIRECTED MUTAGENESIS." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1039030876.

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5

Konishi, Atsushi. "Studies on the thermostabilization of reverse transcriptases from Moloney murine leukemia virus and avian myeloblastosis virus." Kyoto University, 2015. http://hdl.handle.net/2433/199340.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第19016号<br>農博第2094号<br>新制||農||1029(附属図書館)<br>学位論文||H27||N4898(農学部図書室)<br>31967<br>京都大学大学院農学研究科食品生物科学専攻<br>(主査)教授保川清, 教授河田照雄, 教授谷史人<br>学位規則第4条第1項該当

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6

Shaik, Raziya. "Photochemical Generation of the C5' -Uridinyl and Pseudouridinylradical for the Study of Oxidative Damage in RNA." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1384518841.

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7

Andersson, Marie. "Elucidation of the product synthesis of the sesquiterpene synthase Cop6 isolated from Coprinus cinereus." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17252.

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Mushrooms are believed to have a great potential for production of bioactive metabolites e. g. terpenes, a group of interesting compounds with diverse chemical properties such as antitumour and antibacterial activity. Cop6 is a terpene cyclase isolated from the mushroom Coprinus cinereus that catalyzes the cyclization of farnesyl diphosphate (FPP) to mainly α-cuprenene. In this study gas chromatography combined with mass spectroscopy (GC-MS) is used to analyze the product profile of Cop6 mutants created by PCR based site directed mutagenesis. The goal is to produce trichodiene, the parent hydr

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8

Yu, Wenying. "Computational, Synthetic, Biochemical and Biological Studies and Characterization on STAT3 Inhibitors for Potential Anticancer Therapy." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1373328058.

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9

Krebs, Stefan Ralf. "Nonnatural ligands for the human leukocyte antigen HLA-B27 : protein expression, site-directed mutagenesis, peptide syntheses and binding studies." Zürich, 1997. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=12426.

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10

Eren, Mesut. "The design, chemical synthesis, expression in E. coli and site- directed mutagenesis of an artificial gene coding for the flavodoxin from Clostridium mp. /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487684245467148.

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11

Brown, Annette Vitale. "Total synthesis and precursor directed biosynthesis of epothilone analogues." 2004. http://etd.nd.edu/ETD-db/theses/available/etd-08042004-112035/.

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Thesis (Ph. D.)--University of Notre Dame, 2004.<br>Thesis directed by Richard E. Taylor for the Department of Chemistry and Biochemistry. "August 2004." Includes bibliographical references (leaves 179-186).

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12

Naiser, Thomas. "Characterization of oligonucleotide microarray hybridization microarray fabrication by light-directed in situ synthesis - development of an automated DNA microarray synthesizer, characterization of single base mismatch discrimination and the position-dependent influence of point defects on oligonucleotide duplex binding affinities /." 2008. http://opus.ub.uni-bayreuth.de/volltexte/2008/461/.

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13

Naiser, Thomas [Verfasser]. "Characterization of oligonucleotide microarray hybridization : microarray fabrication by light-directed in situ synthesis ; development of an automated DNA microarray synthesizer, characterization of single base mismatch discrimination and the position-dependent influence of point defects on oligonucleotide duplex binding affinities / von Thomas Naiser." 2008. http://d-nb.info/989870049/34.

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14

ZHAO, YIGANG. "Reduction of Tertiary Benzamides to Benzaldehydes by an in situ-Generated Schwartz Reagent (Cp2Zr(H)Cl); Formal Synthesis of Lysergic Acid 2. Ru-Catalyzed Amide-Directed Aryl C-H, C-N and C-O Bond Functionalizations: C-B Formation, C-C Suzuki Cross Coupling and Hydrodemethoxylation." Thesis, 2010. http://hdl.handle.net/1974/6671.

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Chapter 2 of the thesis describes a highly efficient in situ method for the reduction of amides to aldehydes and aryl O-carbamates to phenols and other transformations involving hydrozirconations. The method, as a three-component-type reaction, involves in situ generation of the Schwartz reagent (Cp2Zr(H)Cl) from Cp2ZrCl2 and the reductant, LiAlH(O-t-Bu)3, and immediate reaction with a substrate. Substrates include aliphatic and aromatic tertiary amides which are reduced to aldehydes, aryl O-carbamates which are reduced to phenols, and alkynes which undergo other transformations via hydrozirco

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15

Parrish, Cynthia Ann. "Synthesis of an α,3-Dehydrotoluene Biradical Precursor with DNA Cleaving Activity and Studies Directed Toward the Total Synthesis of Tetracycline". Thesis, 1999. https://thesis.library.caltech.edu/9922/2/Parrish_ca_1999.pdf.

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<p>The synthesis and characterization of a model of the enediyne antibiotics is described. The prepared conjugate consists of an α,3-dehydrotoluene biradical precursor tethered to an N-methylpyrrolecarboxamide minor groove binding element. The conjugate is shown to bind and cleave DNA with sequence selectivity. The binding domain is shown to localize the allene-ene-yne effector domain for sequence-selective DNA cleavage at micromolar concentrations of substrate. The time course of DNA cleavage parallels the rate of cyclization of the bioconjugate in organic solvent to form an α,3-dehydro

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16

(6948542), Emilio Leal Cardenas. "STRUCTURE-BASED DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1." Thesis, 2020.

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<p>Alzheimer’s disease (AD) continues to plague the healthcare community as a serious healthcare crisis. Currently there fails to be an effective FDA approved drug that can treat the underlying mechanisms of the disease. Pathologically the disease is characterized by the accumulation of neurotoxic amyloid-b(Ab) plaques within a diseased patient’s brain. These plaques are widely accepted to be generated by the sequential proteolytic cleavage of amyloid precursor protein (APP) by b-secretase (BACE1, memapsin 2) and g-secretase. Numerous biochemical markers suggest that BACE1 is a viable target f

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17

Hernandez-Buquer, Selene. "Characterization of a fatty acid elongase condensing enzyme by site-directed mutagenesis and biochemical analysis." Thesis, 2014. http://hdl.handle.net/1805/5915.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Fatty acid elongation is the extension of de novo synthesized fatty acids through a series of four reactions analogous to those of fatty acid synthase. ELOs catalyze the first reaction in the elongation pathway through the condensation of an acyl group with a two carbon unit derived from malonyl-CoA. This study uses the condensing enzyme, EloA, from the cellular slime mold, Dictyostelium discoideum as a model for the family of ELOs. EloA has substrate specificity for monounsaturated and saturated C16 fatty acids and catalyzes the elo

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18

Myers, Cullen Lucan. "Investigations of the Natural Product Antibiotic Thiostrepton from Streptomyces azureus and Associated Mechanisms of Resistance." Thesis, 2013. http://hdl.handle.net/10012/7381.

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The persistence and propagation of bacterial antibiotic resistance presents significant challenges to the treatment of drug resistant bacteria with current antimicrobial chemotherapies, while a dearth in replacements for these drugs persists. The thiopeptide family of antibiotics may represent a potential source for new drugs and thiostrepton, the prototypical member of this antibiotic class, is the primary subject under study in this thesis. Using a facile semi-synthetic approach novel, regioselectively-modified thiostrepton derivatives with improved aqueous solubility were prepared. In vivo

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