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Journal articles on the topic 'Prediabetic State/metabolism'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Akinnuga, Akinjide Moses, Angezwa Siboto, Bongiwe Khumalo, Ntethelelo Hopewell Sibiya, Phikelelani Ngubane, and Andile Khathi. "Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model." Canadian Journal of Gastroenterology and Hepatology 2020 (February 20, 2020): 1–9. http://dx.doi.org/10.1155/2020/2475301.

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Background. Prediabetes is an intermediary hyperglycaemic state that precedes type 2 diabetes mellitus (T2DM) in which abnormal metabolism of glucose and lipids occurs in organs such as the liver. Evidence has shown that, about 70% of T2DM patients develop hepatic dysfunction which is found to begin during the prediabetic stage. Bredemolic acid, a pentacyclic triterpene, has been found to improve insulin sensitivity in diet-induced prediabetic rats. The effects of this compound on liver function, however, are unknown. This study was therefore designed to investigate the effects of BA on liver

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de Souza, Milena Cremer, Maria Luisa Gonçalves Agneis, Karoliny Alves das Neves, et al. "Melatonin Improves Lipid Homeostasis, Mitochondrial Biogenesis, and Antioxidant Defenses in the Liver of Prediabetic Rats." International Journal of Molecular Sciences 26, no. 10 (2025): 4652. https://doi.org/10.3390/ijms26104652.

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Type 2 diabetes mellitus represents a major global health burden and is often preceded by a prediabetic state characterized by insulin resistance and metabolic dysfunction. Mitochondrial alterations, oxidative stress, and disturbances in lipid metabolism are central to the prediabetes pathophysiology. Melatonin, a pleiotropic indolamine, is known to regulate metabolic and mitochondrial processes; however, its therapeutic potential in prediabetes remains poorly understood. This study investigated the effects of melatonin on energy metabolism, oxidative stress, and mitochondrial function in a ra

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de Wit-Verheggen, Vera H. W., and Tineke van de Weijer. "Changes in Cardiac Metabolism in Prediabetes." Biomolecules 11, no. 11 (2021): 1680. http://dx.doi.org/10.3390/biom11111680.

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In type 2 diabetes mellitus (T2DM), there is an increased prevalence of cardiovascular disease (CVD), even when corrected for atherosclerosis and other CVD risk factors. Diastolic dysfunction is one of the early changes in cardiac function that precedes the onset of cardiac failure, and it occurs already in the prediabetic state. It is clear that these changes are closely linked to alterations in cardiac metabolism; however, the exact etiology is unknown. In this narrative review, we provide an overview of the early cardiac changes in fatty acid and glucose metabolism in prediabetes and its co

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Shestakova, Ekaterina A., Elena Y. Lunina, Gagik R. Galstyan, Marina V. Shestakova, and Ivan I. Dedov. "Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study." Diabetes mellitus 23, no. 1 (2020): 4–11. http://dx.doi.org/10.14341/dm12286.

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BACKGROUND: Type 2 diabetes (T2D) is multifactorial disease. NATION epidemiological study may provide the information about the prevalence of T2D and prediabetic state in patients with different risk factor combinations in Russian population. AIMS: To evaluate the prevalence of T2D and prediabetic state in NATION cohort depending on the amount of diabetes risk factors. MATERIALS AND METHODS: NATION is an epidemiological, cross-sectional study, designed to assess the prevalence of T2D in Russian adult population, where HbA1c was used to establish T2D (HbAc6,5%) and prediabetes (5,7%

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Baranowska-Jurkun, Angelika, Wojciech Matuszewski, and Elżbieta Bandurska-Stankiewicz. "Chronic Microvascular Complications in Prediabetic States—An Overview." Journal of Clinical Medicine 9, no. 10 (2020): 3289. http://dx.doi.org/10.3390/jcm9103289.

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A prediabetic state is a major risk factor for the development of diabetes, and, because of an identical pathophysiological background of both conditions, their prevalence increases parallelly and equally fast. Long-term hyperglycemia is the main cause inducing chronic complications of diabetes, yet the range of glucose levels at which they start has not been yet unequivocally determined. The current data show that chronic microvascular complications of diabetes can be observed in patients with abnormal glucose metabolism in whom glycaemia is higher than optimal but below diagnostic criteria f

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Abdollahi, Milad, Sayyed Mohammad Marandi, Kamran Ghaedi, et al. "Insulin-Related Liver Pathways and the Therapeutic Effects of Aerobic Training, Green Coffee, and Chlorogenic Acid Supplementation in Prediabetic Mice." Oxidative Medicine and Cellular Longevity 2022 (February 24, 2022): 1–14. http://dx.doi.org/10.1155/2022/5318245.

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Background. The liver controls blood glucose levels via regulation of anabolic (glycogen synthesis and gluconeogenesis) and catabolic (glycolysis and glycogenolysis) processes through activation of the PI3K-AKT signalling pathway. The aim of this study was to assess the effect of aerobic training, green coffee, and chlorogenic acid supplementation on glucose metabolism-regulating pathways in prediabetic mice. Methods. C57BL/6 mice were exposed to a high-fat diet and physical activity limitation to induce a state of prediabetes. After 12 weeks, mice were fed a high-fat diet compared to the cont

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Papaetis, Georgios S. "Liraglutide Therapy in a Prediabetic State: Rethinking the Evidence." Current Diabetes Reviews 16, no. 7 (2020): 699–715. http://dx.doi.org/10.2174/1573399816666191230113446.

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Background: Prediabetes is defined as a state of glucose metabolism between normal glucose tolerance and type 2 diabetes. Continuous β-cell failure and death are the reasons for the evolution from normal glucose tolerance to prediabetes and finally type 2 diabetes. Introduction: The necessity of new therapeutic approaches in order to prevent or delay the development of type 2 diabetes is obligatory. Liraglutide, a long-acting GLP-1 receptor agonist, has 97% homology for native GLP-1. Identification of the trophic and antiapoptotic properties of liraglutide in preclinical studies, together with

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Paprott, Rebecca, Christa Scheidt-Nave, and Christin Heidemann. "Determinants of Change in Glycemic Status in Individuals with Prediabetes: Results from a Nationwide Cohort Study in Germany." Journal of Diabetes Research 2018 (October 14, 2018): 1–12. http://dx.doi.org/10.1155/2018/5703652.

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Previous studies investigating determinants of changes in glycemic status among individuals with prediabetes mainly focused on glucose-defined prediabetes. In this study, we examined determinants of a regression to normoglycemia or a progression to diabetes among individuals with HbA1c-defined prediabetes. The study included 817 participants (18–79 years) with prediabetes (HbA1c 5.7–6.4% (39–47 mmol/mol)) at baseline. Glycemic status at follow-up was categorized as diagnosed diabetes (self-reported physician diagnosis or antidiabetic medication), undiagnosed diabetes (HbA1c ≥ 6.5% (≥48 mmol/mo

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Knezek, Savanah, Marielle Engelen, Gabriella Ten Have, John Thaden, and Nicolaas Deutz. "Prediabetes Is Associated with Specific Changes in Valine Metabolism." Current Developments in Nutrition 6, Supplement_1 (2022): 34. http://dx.doi.org/10.1093/cdn/nzac047.034.

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Abstract Objectives Recent studies have suggested that a high plasma concentration of the branched-chain amino acids (BCAAs) can serve as a biomarker for type-2-diabetes (T2D). Whether this is also the case for prediabetes remains unclear. Our goal is to examine whether specific disturbances exist in the kinetics of the BCAAs leucine, isoleucine and valine in middle aged/older adults with prediabetes. Methods We measured BCAA kinetics in 70 prediabetic subjects (fasting glucose: 5.7-6.5 mM), 47 diabetic subjects (fasting glucose: ≥6.5 mM, or are taking medication to control blood glucose) and

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Dreval', Alexander Vasil'evich, Irina Vladimirovna Trigolosova, and Inna Vladimirovna Misnikova. "Leptin secretion and severity of glycemic disorders in women with body weight excess." Diabetes mellitus 16, no. 2 (2013): 67–72. http://dx.doi.org/10.14341/2072-0351-3758.

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Aim. To characterize leptin secretion in fasting state and upon intravenous glucose administration in patients with type 2 diabetes mel- litus (T2DM), prediabetes and obesity. Materials and methods. 59 female patients took part in this study: 12 had no signs of glycemic disorder, 18 were diagnosed with prediabetes and 30 ? with newly diagnosed T2DM. Median age was 54 [48.6?60] years, median BMI ? 33.2 [29.0?37.2] kg/m2. All participants were tested for fasting leptin, fasting insulin and blood glucose levels. Prediabetic and diabetic subjects also received a bolus intravenous injection of 40%

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Kostara, Christina E., Kiriaki S. Karakitsou, Matilda Florentin, Eleni T. Bairaktari, and Vasilis Tsimihodimos. "Progressive, Qualitative, and Quantitative Alterations in HDL Lipidome from Healthy Subjects to Patients with Prediabetes and Type 2 Diabetes." Metabolites 12, no. 8 (2022): 683. http://dx.doi.org/10.3390/metabo12080683.

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Prediabetes is a clinically silent, insulin-resistant state with increased risk for the development of type 2 diabetes (T2D) and cardiovascular disease (CVD). Since glucose homeostasis and lipid metabolism are highly intersected and interrelated, an in-depth characterization of qualitative and quantitative abnormalities in lipoproteins could unravel the metabolic pathways underlying the progression of prediabetes to T2D and also the proneness of these patients to developing premature atherosclerosis. We investigated the HDL lipidome in 40 patients with prediabetes and compared it to that of 40

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Yoshida, Sumiko, Emiko Aizawa, Naoko Ishihara, Kotaro Hattori, Kazuhiko Segawa, and Hiroshi Kunugi. "High Rates of Abnormal Glucose Metabolism Detected by 75 g Oral Glucose Tolerance Test in Major Psychiatric Patients with Normal HbA1c and Fasting Glucose Levels." Nutrients 17, no. 4 (2025): 613. https://doi.org/10.3390/nu17040613.

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Objectives: Comorbid diabetes is an important factor in the treatment of major psychiatric disorders. However, a substantial proportion of diabetic patients remain undetected by routine diabetic indices such as blood glucose and HbA1c. This study tried to estimate rates of such unidentified diabetic or prediabetic patients by using a 75 g oral glucose tolerance test (OGTT). Methods: Participants in the test were 25 patients with major depressive disorder (MDD), 28 patients with bipolar disorder (BP), 26 patients with schizophrenia, and 28 psychiatrically normal controls. They were all Japanese

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Lerat, Hervé, Mohamed Rabah Imache, Jacqueline Polyte, et al. "Hepatitis C virus induces a prediabetic state by directly impairing hepatic glucose metabolism in mice." Journal of Biological Chemistry 292, no. 31 (2017): 12860–73. http://dx.doi.org/10.1074/jbc.m117.785030.

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Haffner, S. M., C. Gonzales, R. A. Valdez, et al. "Is microalbuminuria part of the prediabetic state? The Mexico City Diabetes Study." Diabetologia 36, no. 10 (1993): 1002–6. http://dx.doi.org/10.1007/bf02374491.

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Ding, Yilan, Shuangyuan Wang, and Jieli Lu. "Unlocking the Potential: Amino Acids’ Role in Predicting and Exploring Therapeutic Avenues for Type 2 Diabetes Mellitus." Metabolites 13, no. 9 (2023): 1017. http://dx.doi.org/10.3390/metabo13091017.

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Diabetes mellitus, particularly type 2 diabetes mellitus (T2DM), imposes a significant global burden with adverse clinical outcomes and escalating healthcare expenditures. Early identification of biomarkers can facilitate better screening, earlier diagnosis, and the prevention of diabetes. However, current clinical predictors often fail to detect abnormalities during the prediabetic state. Emerging studies have identified specific amino acids as potential biomarkers for predicting the onset and progression of diabetes. Understanding the underlying pathophysiological mechanisms can offer valuab

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Kovács, Györgyi, Barbara Buday, Attila Fék, et al. "Metabolic differences in healthy first-degree female relatives of type 2 diabetic patients." Orvosi Hetilap 154, no. 44 (2013): 1747–53. http://dx.doi.org/10.1556/oh.2013.29737.

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Introduction: Today the prevalence of type 2 diabetes reached an epidemic level. It is known that type 2 diabetes could only be prevented before the manifestation, during the “prediabetic” state, urging the development of diagnostic tests to recognize the group at risk in time. Aim: The authors explored metabolic differences between healthy, normal glucose tolerant, normal insulin resistant females having first degree relatives with and without type 2 diabetes. Method: Healthy, normal insulin sensitive females without (n = 26) and with (n = 18) type 2 diabetic relatives were investigated. Resu

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Weninger, Savanna N., Angela Ding, Elizabeth N. Browne, et al. "Longitudinal Characterization of the Gut Microbiota in the Diabetic ZDSD Rat Model and Therapeutic Potential of Oligofructose." Metabolites 13, no. 5 (2023): 660. http://dx.doi.org/10.3390/metabo13050660.

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The complex development of type 2 diabetes (T2D) creates challenges for studying the progression and treatment of the disease in animal models. A newly developed rat model of diabetes, the Zucker Diabetic Sprague Dawley (ZDSD) rat, closely parallels the progression of T2D in humans. Here, we examine the progression of T2D and associated changes in the gut microbiota in male ZDSD rats and test whether the model can be used to examine the efficacy of potential therapeutics such as prebiotics, specifically oligofructose, that target the gut microbiota. Bodyweight, adiposity, and fed/fasting blood

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Tripathy, D., Å L. Carlsson, M. Lehto, B. Isomaa, T. Tuomi, and L. Groop. "Insulin secretion and insulin sensitivity in diabetic subgroups: studies in the prediabetic and diabetic state." Diabetologia 43, no. 12 (2000): 1476–83. http://dx.doi.org/10.1007/s001250051558.

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Yulug, Burak, Ozlem Saatci, Aysun Işıklar, et al. "The Association between HbA1c Levels, Olfactory Memory and Cognition in Normal, Pre-Diabetic and Diabetic Persons." Endocrine, Metabolic & Immune Disorders - Drug Targets 20, no. 2 (2020): 198–212. http://dx.doi.org/10.2174/1871530319666190614121738.

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Background and Aim: Recent data have shown that olfactory dysfunction is strongly related to Alzheimer’s Disease (AD) that is often preceded by olfactory deficits suggesting that olfactory dysfunction might represent an early indicator of future cognitive in prediabetes. Methods: We have applied to a group of normal (n=15), prediabetic (n=16) and type 2 diabetic outpatients (n=15) olfactory testing, 1.5-T MRI scanner and detailed cognitive evaluation including the standard Mini-Mental State Examination (MMSE) form, Short Blessed Test (SBT), Letter Fluency Test (LFT) and the category fluency te

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Mbatha, Nonkululeko Avril, Aganze Gloire-Aimé Mushebenge, and Andile Khathi. "Identification of Putative Causal Relationships between Blood-Based Biomarkers and Prediabetes-Induced Senescence: A Comprehensive Review." Physiologia 4, no. 2 (2024): 149–81. http://dx.doi.org/10.3390/physiologia4020009.

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Prediabetes, a pivotal phase in glucose metabolism between normalcy and diabetes, exerts a profound influence on the aging process and the risk of age-related diseases. This comprehensive review delves into the intricate web of blood-based biomarkers that collectively expedite senescence, marking the transition from a state of health to age-related complications. Key findings underscore the significance of diverse biomarkers, such as telomere length, p16INK4a, senescence-associated secretory phenotype (SASP) factors, DNA methylation clocks, advanced glycation end products (AGEs), inflammatory

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Kosaryan, Mehrnoush, Malihe Rahimi, Daniel Zamanfar та Hadi Darvishi-Khezri. "Liver iron concentration is an independent risk factor for the prediabetic state in β-thalassemia patients". International Journal of Diabetes in Developing Countries 40, № 2 (2020): 227–34. http://dx.doi.org/10.1007/s13410-019-00789-0.

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Liebmann, Moritz, Melissa Asuaje Pfeifer, Katharina Grupe, and Stephan Scherneck. "Estradiol (E2) Improves Glucose-Stimulated Insulin Secretion and Stabilizes GDM Progression in a Prediabetic Mouse Model." International Journal of Molecular Sciences 23, no. 12 (2022): 6693. http://dx.doi.org/10.3390/ijms23126693.

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Female New Zealand obese (NZO) mice are an established model of preconceptional (pc.) prediabetes that progresses as gestational diabetes mellitus (GDM) during gestation. It is known that NZO mice show improvement in insulin sensitivity and glucose-stimulated insulin secretion (GSIS) during gestation in vivo. The latter is no longer detectable in ex vivo perifusion experiments in isolated islets of Langerhans, suggesting a modulation by extrapancreatic factors. Here, we demonstrated that plasma 17β-estradiol (E2) levels increased markedly in NZO mice during gestation. The aim of this work was

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Méan, Marie, Gérard Waeber, and Pedro Marques-Vidal. "Do Hospital Doctors Screen for Diabetes?" Experimental and Clinical Endocrinology & Diabetes 127, no. 08 (2018): 511–16. http://dx.doi.org/10.1055/a-0598-4682.

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Abstract Background One in five hospitalized patients presents with previously undetected diabetes mellitus (DM). We assessed whether hospital doctors measure HbA1c in hospitalized patients and act consequently. Methods Data from patients hospitalized between January 2013 and December 2014 in a Swiss teaching hospital was collected. We assessed the frequency of HbA1c measurements and the number of newly detected prediabetes or DM. We also examined whether HbA1c values were associated with the antidiabetic drugs prescription and reporting of DM in the discharge letter. Results Of the 2618 patie

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Burhop, Milena, Jan Philipp Schuchardt, Josefine Nebl, Mattea Müller, Ralf Lichtinghagen, and Andreas Hahn. "Marine Oil from C. finmarchicus Enhances Glucose Homeostasis and Liver Insulin Resistance in Obese Prediabetic Individuals." Nutrients 14, no. 2 (2022): 396. http://dx.doi.org/10.3390/nu14020396.

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The intermediate state between normal glucose tolerance and overt type 2 diabetes mellitus is associated with micro- and macrovascular diseases, requiring safe and cost-effective treatment measures interventions. A novel source of LC n-3 FAs is Calanus finmarchicus Oil, which showed promising effects on glucose homeostasis in preclinical studies due to anti-obesity effects and/or anti-inflammatory properties. In total, 43 obese patients (BMI: 31.7 ± 5.2 kg/m2) were allocated in the following two groups: (1) Calanus oil group (2 g CO/day) and (2) placebo group (2 g paraffin oil/day). Markers of

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Blaak, Ellen E. "Characterisation of fatty acid metabolism in different insulin-resistant phenotypes by means of stable isotopes." Proceedings of the Nutrition Society 76, no. 3 (2017): 419–24. http://dx.doi.org/10.1017/s0029665116003013.

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The obese insulin resistant and/or prediabetic state is characterised by systemic lipid overflow, mainly driven by an impaired lipid buffering capacity of adipose tissue, and an impaired capacity of skeletal muscle to increase fat oxidation upon increased supply. This leads to the accumulation of bioactive lipid metabolites in skeletal muscle interfering with insulin sensitivity via various mechanisms. In this review, the contribution of dietary v. endogenous fatty acids to lipid overflow, their extraction or uptake by skeletal muscle as well as the fractional synthetic rate, content and compo

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Cali', Anna M. G., Riccardo C. Bonadonna, Maddalena Trombetta, Ram Weiss, and Sonia Caprio. "Metabolic Abnormalities Underlying the Different Prediabetic Phenotypes in Obese Adolescents." Journal of Clinical Endocrinology & Metabolism 93, no. 5 (2008): 1767–73. http://dx.doi.org/10.1210/jc.2007-1722.

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Abstract Objective: The aim of this study was to define the metabolic abnormalities underlying the prediabetic status of isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), and combined IFG/IGT in obese youth. Research Design and Methods: We used state-of-the-art techniques (hyperinsulinemic-euglycemic and hyperglycemic clamps), applying a model of glucose-stimulated insulin secretion to the glucose and C-peptide concentration, in 40 normal glucose tolerance (NGT), 17 IFG, 23 IGT, and 11 IFG/IGT obese adolescents. Percent fat (by dual-energy x-ray absorptiometry

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Keenan, Daniel M., Johannes D. Veldhuis, Ananda Basu, and Rita Basu. "A novel measure of glucose homeostasis (or loss thereof) comprising the joint dynamics of glucose, insulin, glucagon, and cortisol." American Journal of Physiology-Endocrinology and Metabolism 316, no. 6 (2019): E998—E1011. http://dx.doi.org/10.1152/ajpendo.00078.2018.

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Quantification of disturbances in glucose-insulin homeostasis has been the cornerstone of appraising insulin resistance and detecting early-stage diabetes. Metabolic homeostasis arises from feedback and feed-forward interactions among (at least) all four of glucose, insulin, glucagon, and cortisol. Quantifying such tetrapartite interactions in the fasting (endogenously regulated) state overnight could elucidate very early regulatory disruption. In the present study, healthy subjects without diabetes (ND; n = 20) and patients with Type 2 diabetes (T2D; n = 21) were investigated by repeated over

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Mensink, M., M. K. C. Hesselink, L. B. Borghouts, et al. "Skeletal muscle uncoupling protein-3 restores upon intervention in the prediabetic and diabetic state: implications for diabetes pathogenesis?" Diabetes, Obesity and Metabolism 9, no. 4 (2007): 594–96. http://dx.doi.org/10.1111/j.1463-1326.2006.00628.x.

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Joseph, Anu, S. Parvathy, and Koyikkal Karthikeya Varma. "Hyperinsulinemia Induced Altered Insulin Signaling Pathway in Muscle of High Fat- and Carbohydrate-Fed Rats: Effect of Exercise." Journal of Diabetes Research 2021 (February 23, 2021): 1–10. http://dx.doi.org/10.1155/2021/5123241.

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Insulin resistance is a state of impaired responsiveness to insulin action. This condition not only results in deficient glucose uptake but increases the risk for cardiovascular diseases (CVD), stroke, and obesity. The present work investigates the molecular mechanisms of high carbohydrate and fat diet in inducing prediabetic hyperinsulinemia and effect of exercise on InsR signaling events, muscular AChE, and lactate dehydrogenase activity. Adult male Wistar rats were divided into the control (C) diet group, high-carbohydrate diet (HCD) group, high-fat diet (HFD) group, and HCD and HFD groups

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Bakkar, Nour-Mounira Z., Nahed Mougharbil, Ali Mroueh, et al. "Worsening baroreflex sensitivity on progression to type 2 diabetes: localized vs. systemic inflammation and role of antidiabetic therapy." American Journal of Physiology-Endocrinology and Metabolism 319, no. 5 (2020): E835—E851. http://dx.doi.org/10.1152/ajpendo.00145.2020.

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Cardiac autonomic neuropathy (CAN) is an early cardiovascular manifestation of type 2 diabetes (T2D) that constitutes an independent risk factor for cardiovascular mortality and morbidity. Nevertheless, its underlying pathophysiology remains poorly understood. We recently showed that localized perivascular adipose tissue (PVAT) inflammation underlies the incidence of parasympathetic CAN in prediabetes. Here, we extend our investigation to provide a mechanistic framework for the evolution of autonomic impairment as the metabolic insult worsens. Early metabolic dysfunction was induced in rats fe

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Park, Sunmin, Chan-Joong Kim, Ki-Chan Ha, et al. "Efficacy and Safety of Aronia, Red Ginseng, Shiitake Mushroom, and Nattokinase Mixture on Insulin Resistance in Prediabetic Adults: A Randomized, Double-Blinded, Placebo-Controlled Trial." Foods 10, no. 7 (2021): 1558. http://dx.doi.org/10.3390/foods10071558.

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We determined whether oral consumption of Aronia, red ginseng, shiitake mushroom, and nattokinase mixture (3.4: 4.1: 2.4: 0.1 w/w; AGM) improved glucose metabolism and insulin resistance in prediabetic adults in a 12-week randomized, double-blinded clinical trial. Participants with fasting serum glucose concentrations of 100–140 mg/dL were recruited and randomly assigned to an AGM or placebo group. Participants of the AGM group (n = 40) were given an AGM granule containing 4 g of freeze-dried Aronia, red ginseng, shiitake mushroom, and nattokinase (3.4: 4.1: 2.4: 0.1 w/w) twice daily for 12 we

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Bounias, Ioannis, Stamatia Pouliliou, Gregory Tripsianis, et al. "Ghrelin Levels in Basal Conditions and During Glucose Tolerance Test in Prediabetic and Diabetic Patients." Hormone and Metabolic Research 50, no. 11 (2018): 822–26. http://dx.doi.org/10.1055/a-0746-4014.

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AbstractGhrelin is associated with glucose homeostasis but its’ possible relevance with glucose levels in physiological and pathological conditions has so far been poorly investigated. The aim of the present study was to evaluate circulating ghrelin levels in prediabetic and diabetic patients in basal conditions and in response to oral glucose tolerance test (OGTT). A total of 90 male adults aged 40 – 73 years old were enrolled in our study. Fasting and postprandial plasma ghrelin, insulin and glucose levels were measured at 0, 60, 120 and 180 min following an OGTT in 40 patients with type 2 d

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Woehrle, M., K. Blumrich, R. G. Bretzel, and K. Federlin. "A comparative study of antigen expression by skin and pancreas in the prediabetic and diabetic state of the BB rat." Acta Diabetologica 28, no. 3-4 (1992): 215–20. http://dx.doi.org/10.1007/bf00779002.

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Motterle, Anna, Sonia Gattesco, Dorothée Caille, Paolo Meda, and Romano Regazzi. "Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice." Diabetologia 58, no. 8 (2015): 1827–35. https://doi.org/10.1007/s00125-015-3641-5.

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AIMS/HYPOTHESIS: Exposure of pancreatic beta cells to cytokines released by islet-infiltrating immune cells induces alterations in gene expression, leading to impaired insulin secretion and apoptosis in the initial phases of type 1 diabetes. Long non-coding RNAs (lncRNAs) are a new class of transcripts participating in the development of many diseases. As little is known about their role in insulin-secreting cells, this study aimed to evaluate their contribution to beta cell dysfunction. METHODS: The expression of lncRNAs was determined by microarray in the MIN6 beta cell line exposed to proin

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Füllert, S., F. Schneider, E. Haak, et al. "Effects of Pioglitazone in Nondiabetic Patients with Arterial Hypertension: A Double-Blind, Placebo-Controlled Study." Journal of Clinical Endocrinology & Metabolism 87, no. 12 (2002): 5503–6. http://dx.doi.org/10.1210/jc.2002-020963.

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Abstract Hypertension is often associated with insulin resistance, dyslipidemia and obesity, which indicate a prediabetic state and increased risk of cardiovascular disease. Pioglitazone treatment of patients with type 2 diabetes reduces insulin resistance and improves lipid profiles. The present double-blind placebo-controlled study is the first study to report effects of pioglitazone in non-diabetic patients with arterial hypertension. Following a one week run-in, 60 patients were randomized to receive either pioglitazone (45 mg/day) or placebo for 16 weeks. Insulin sensitivity (M-value) inc

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Cho, You-Ree, Hyo-Jeong Kim, So-Young Park, et al. "Hyperglycemia, maturity-onset obesity, and insulin resistance in NONcNZO10/LtJ males, a new mouse model of type 2 diabetes." American Journal of Physiology-Endocrinology and Metabolism 293, no. 1 (2007): E327—E336. http://dx.doi.org/10.1152/ajpendo.00376.2006.

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As a new mouse model of obesity-induced diabetes generated by combining quantitative trait loci from New Zealand Obese (NZO/HlLt) and Nonobese Nondiabetic (NON/LtJ) mice, NONcNZO10/LtJ (RCS10) male mice developed type 2 diabetes characterized by maturity onset obesity, hyperglycemia, and insulin resistance. To metabolically profile the progression to diabetes in preobese and obese states, a 2-h hyperinsulinemic euglycemic clamp was performed and organ-specific changes in insulin action were assessed in awake RCS10 and NON/LtJ (control) males at 8 and 13 wk of age. Prior to development of obesi

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Poorhosseini, Hamidreza, Hamed Tavolinejad, Arya Aminorroaya, et al. "The association of statins for secondary prevention with progression to diabetes in patients with prediabetic state after coronary artery bypass graft surgery: A retrospective cohort study." Journal of Diabetes and its Complications 34, no. 12 (2020): 107713. http://dx.doi.org/10.1016/j.jdiacomp.2020.107713.

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Yalcin, Mehmet Muhittin, Alev Eroglu Altinova, Mujde Akturk, et al. "GDF-15 and Hepcidin Levels in Nonanemic Patients with Impaired Glucose Tolerance." Journal of Diabetes Research 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/1240843.

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Aims. Growth Differentiation Factor-15 (GDF-15) has been suggested as one of the regulators of hepcidin, an important regulatory peptide for iron deposition. Current data is conflicting about the relationship between hepcidin and disorders of glucose metabolism. We aimed to investigate serum hepcidin and GDF-15 concentrations and their associations with each other, in nonanemic subjects with impaired glucose tolerance (IGT) in comparison with the nonanemic subjects with normal glucose tolerance (NGT).Methods. Thirty-seven subjects with IGT and 32 control subjects with NGT, who were age-, gende

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Pisaruk, Anatoly, Ervin Asanov, Svitlana Naskalova, et al. "Effects of war-related stress on the cardiovascular system, metabolism and the rate of ageing in women." Ageing & Longevity, no. 1 2024 (February 9, 2024): 21–28. http://dx.doi.org/10.47855/jal9020-2024-5-3.

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Chronic war-related stress (WRS) due to disruption of adaptation mechanisms can affect physiological processes in the body, in particular, metabolism, neuroendocrine regulation, and the state of the cardiovascular and respiratory systems. WRS can also cause changes in the body's rate of ageing. Purpose of the Study: To investigate the effects of WRS on the cardiovascular system, metabolism and the rate of ageing in women. The study included 91 women aged from 30 to 74 years who experienced chronic WRS and 79 women examined before the Russian-Ukrainian war (control group). The biological age (B

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Ibrahim, Ibrahim, and Sherwan Salih. "Serum Irisin In Individuals with Type 2 Diabetes Mellitus and Prediabetes in Duhok City." Journal of Life and Bio Sciences Research 3, no. 02 (2022): 59–64. http://dx.doi.org/10.38094/jlbsr30277.

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Type 2 diabetes mellitus is one of the most common chronic metabolic diseases characterized by hyperglycemia, with either lack of insulin secretion or decreased sensitivity to insulin metabolic effects. Prediabetes is an intermediate stage between normal glucose metabolism and diabetes mellitus with high prevalence rate of diabetes mellitus developments. We aimed in this study to evaluate serum irisin level among patients with type 2 diabetes mellitus and individuals with prediabetes. A cross-sectional study was done on 214 participants, who were attend to the Azadi Teaching Hospital, Diabetic

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von Eckardstein, Arnold, Helmut Schulte, and Gerd Assmann. "Risk for Diabetes Mellitus in Middle-Aged Caucasian Male Participants of the PROCAM Study: Implications for the Definition of Impaired Fasting Glucose by the American Diabetes Association." Journal of Clinical Endocrinology & Metabolism 85, no. 9 (2000): 3101–8. http://dx.doi.org/10.1210/jcem.85.9.6773.

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Abstract The criteria of the American Diabetes Association and the WHO for the diagnosis of diabetes mellitus are controversially discussed. In a prospective population study, we evaluated the data of 3737 men, aged 36–60 yr, without diabetes mellitus and with fasting serum glucose levels less than 7 mmol/L at entry into the study who had at least 1 repeat examination during a follow-up of 4–10 yr. During a mean follow-up of 6.3 yr, 200 men developed diabetes mellitus. They differed significantly from 3537 men by body mass index, fasting serum levels of glucose, high density lipoprotein choles

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Keller. "From Obesity to Diabetes." International Journal for Vitamin and Nutrition Research 76, no. 4 (2006): 172–77. http://dx.doi.org/10.1024/0300-9831.76.4.172.

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The prevalence of obesity has been increasing dramatically in the last decades in the whole world, not only in industrialized countries but also in developing areas. A major complication of obesity is insulin resistance and type 2 diabetes. Diabetes is also rapidly increasing world-wide – reaching a prevalence in adults of approx. 5–6% in Central Europe and in the US, and more than 50% in specific, genetically prone populations. This article reviews pathogenetic mechanisms linking obesity and type 2 diabetes. Emphasis is placed on the observation that excessive amounts of adipocytes are associ

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Min'kova, Nadezhda B., Oleg Iu Latyshev, Goar F. Okminyan, Elena V. Kiseleva, Dar'ia S. Romaikina, and Liubov N. Samsonova. "Insulin resistance and its role in the pathogenesis of pre-diabetes development in obese adolescents." Consilium Medicum 25, no. 8 (2023): 524–28. http://dx.doi.org/10.26442/20751753.2023.8.202342.

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Background. The prevalence of childhood obesity has increased significantly over the past three decades worldwide, and in this regard, the frequency of diseases associated with obesity, including disorders of carbohydrate metabolism, has increased. The involvement of insulin resistance and insulin deficiency in the development of prediabetes in obesity has been established. However, the significance of each pathological mechanism in the development of prediabetes in childhood and adolescence has not been established. In this regard, in children's practice, there is no reliable data on methods

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Petunina, Nina A., Narine S. Martirosian, Mikhail V. Khachaturov, et al. "Diagnosis and treatment of prediabetes as prevention of type 2 diabetes: A review." Consilium Medicum 25, no. 4 (2023): 229–35. http://dx.doi.org/10.26442/20751753.2023.4.202312.

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Prediabetes is defined as a disorder in which the criteria for diabetes mellitus are not met, but normal blood glucose values are exceeded; this intermediate hyperglycemia is associated with a high risk of developing diabetes and cardiovascular disease. The number of patients with diabetes mellitus continues to grow steadily, and therefore the role of timely interventions at the stage of prediabetes is obvious. A modern approach to preventing the progression of prediabetes includes correcting risk factors for cardiovascular diseases, arterial hypertension, dyslipidemia, weight loss and/or prev

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Kim, Dong-Min, and Sunghwun Kang. "Effects of Regulatory Resistance Exercise on Brain Neuroplasticity Factors in Prediabetic Elderly." Exercise Science 30, no. 1 (2021): 88–95. http://dx.doi.org/10.15857/ksep.2021.30.1.88.

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PURPOSE: The purpose of this study was to determine whether regulatory resistance exercise is as effective as aerobic training at improving the blood levels of brain-derived neurotrophic factor (BDNF), and nerve growth factors (NGF) as well as Cathepsin B, which are major factors contributing to the regulation of glucose metabolism and neuroplasticity, in prediabetic elderly.METHODS:Among the elderly aged 65 years or older who attended the B welfare center in C city, 16 patients who had no disease and had HbA1c of 5.7-6.4% were randomly assigned into either control group (CO, n=8, age 69.12±2.

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Bashir, Mir Iftikhar, Arshad Iqbal Wani, and Shariq R. Masoodi. "Prediabetes." JMS SKIMS 14, no. 1 (2011): 4–10. http://dx.doi.org/10.33883/jms.v14i1.62.

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Pre-diabetes is a metabolic condition characterized by insulin resistance and primary or secondary beta cell dysfunction which increases the risk of developing type 2 diabetes mellitus. It is used to describe the intermediate state of abnormal glucose metabolism in which blood glucose levels are higher than normal, but not yet in the range necessary for diagnosis of diabetes. The concept of prediabetes arose in 1950’s when high perinatal mortality was reported in pregnancies before diagnosis of diabetes mellitus. Prediabetes was included in the classification of glucose tolerance in the 1965 W

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Lyabina, N. V., O. I. Simonova, I. V. Shirokova та ін. "The features of carbohydrate metabolism in children with cystic ﬁ brosis: a 30-year-long history". Experimental and Clinical Gastroenterology, № 3 (4 жовтня 2022): 93–106. http://dx.doi.org/10.31146/1682-8658-ecg-199-3-93-106.

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Th e article presents a review on a cystic ﬁbrosis-r elated diabetes, a severe complication of cystic ﬁ brosis in children, which has acquired increasing importance and revealed to contribute in prognosis of the disease in recent years. Which include resent and historical epidemiology, pathophysiology, diagnostic methods, features of the course and the latest aspects of the targeted therapy eﬀect on endocrine function of the pancreas. The authors presented a retrospective analysis of the carbohydrate metabolism condition in two groups of children with cystic ﬁ brosis investigated in 1993 and 2

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Demidova, T. Y., and V. M. Plakhotnyaya. "Prediabetes. A new paradigm for early prevention of cardiovascular disease." Meditsinskiy sovet = Medical Council, no. 14 (October 18, 2021): 124–32. http://dx.doi.org/10.21518/2079-701x-2021-14-124-132.

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This literature review focuses on the association of prediabetes with cardiovascular disease (CVD). Recently, much attention has been paid to the study of prediabetes due to its extremely high prevalence and strong association with a high risk of developing serious complications that worsen the quality of kife of patients. Prediabetes is not only a metabolic condition with a high risk of developing type 2 diabetes mellitus (T2DM), but also CVD and death from all causes. This association is true for both patients who do not yet have CVD and those with a history of CVD. Also during the COVID-19

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Morgunova, T. B., I. V. Glinkina, and V. V. Fadeev. "Prediabetes: challenges and opportunities." Meditsinskiy sovet = Medical Council, no. 12 (September 19, 2021): 220–27. http://dx.doi.org/10.21518/2079-701x-2021-12-220-227.

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In the world, the number of patients with carbohydrate metabolism disorders is steadily growing. Over the past 10 years, the number of patients with diabetes mellitus in the world has more than doubled. Moreover, there is not only an increase in the number of patients with diabetes mellitus, predominantly type 2 diabetes, but also with prediabetes. The term «prediabetes» means impaired glucose tolerance and impaired fasting glycemia. To date, it is obvious that the development of prediabetes lead not only to the higher risk of diabetes mellitus in the future, but also of cardiovascular disease

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Liu, Rui, Gabriella H. Pugh, Erin Tevonian, et al. "Regulatory T Cells Control Effector T Cell Inflammation in Human Prediabetes." Diabetes 71, no. 2 (2021): 264–74. http://dx.doi.org/10.2337/db21-0659.

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A disparate array of plasma/serum markers provides evidence for chronic inflammation in human prediabetes, a condition that is most closely replicated by standard mouse models of obesity and metaflammation. These remain largely nonactionable and contrast with our rich understanding of inflammation in human type 2 diabetes. New data show that inflammatory profiles produced by CD4+ T cells define human prediabetes as a unique inflammatory state. Regulatory T cells (Treg) control mitochondrial function and cytokine production by CD4+ effector T cells (Teff) in prediabetes and type 2 diabetes by s

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