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Bukhari, Syeda Rabia, Alia Firdus, Sadaf Jalal, Lamia Yusuf, Surraya Israr, and Amanullah Bhutto. "Plasma Lipid and Lipoprotein Concentrations in Pregnancy Induced Hypertension." Pakistan Journal of Medical and Health Sciences 16, no. 12 (2022): 884–86. http://dx.doi.org/10.53350/pjmhs20221611884.
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Background and aim: Variation in serum lipid profile is associated with hypertension. Abnormal lipid profile directly affects the endothelial dysfunction and significantly associated with atherosclerotic cardiovascular diseases. Hypertension is the pregnancy toxaemia associated key feature which is considered to be caused by vasospastic phenomena in placenta, kidney, brain, and uterus. The current study aimed to assess plasma lipid and lipoprotein concentrations in pregnant women with hypertension (PIH). Methods: This study was conducted on 66 (36 PIH cases, 30 control cases) age matched women in the Department of Obstetrics and Gynecology, Moulvi Ameer Shah Memorial Hospital, Peshawar from October 2021 to June 2022. The criteria for preeclampsia were proteinuria, and proteinuria after pregnancy, hypertension, edema, and reversal of hypertension. Subjects' fasting venous blood samples were collected. Plasma was isolated from heparine anticoagulated blood. In a preservative bottle (500 mg/1000 mL urine) of Na2B4O7, urine was collected after 24 hours. Urine and plasma were kept at -80°C until the assay. Total cholesterol levels, HDL-C, and triglyceride were enzymatically measured. The amount of spectrophotometric and malondialdehyde was measured for plasma lipid peroxidation. SPSS version 26 was used for data analysis. Results: There was a significant increase in proteinuria, mean diastolic, and systolic pressure of preeclampsia patients than the control group. Total triglyceride, malondialdehyde (MDA), low density lipoprotein cholesterol (LDL-C), and apolipoprotein B (apo-B) in a study group were significantly higher as compared to control. Whereas the study group had lower high density lipoprotein cholesterol (HDL-C) than that of control group. The total cholesterol concentration, plasma protein, gestational age, apo-A, and hemoglobin had no statistical significance in both groups. Conclusion: The present study suggested that abnormal lipid metabolism, high triglycerides, specifically LDL-C and lipid peroxides, and low HDL-C concentrations, may lead to the vascular dysfunction and preeclampsia is associated with oxidative stress. There are only minor differences in lipoprotein concentrations and serum lipid between PIH women and women with uncomplicated pregnancy. Keywords: Plasma lipid, Lipoprotein concentration, Pregnancy-induced hypertension
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a, Himabindu, G. Rama, Arjumand Bano, and Himasailakshmi Prasanna. "STUDY OF MATERNAL LIPID PROFILE IN PREECLAMPSIA." International Journal of Advanced Research 10, no. 12 (2022): 63–66. http://dx.doi.org/10.21474/ijar01/15808.
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Introduction: This study evaluates relationship between serum lipid profile and preeclampsia1 . Objective:The study is to compare the mean lipid levels in pre-eclamptic and normal pregnancy. Design:This is a descriptive study. Participants: Among patients attending Out Patient Department in Chalmeda Anand Rao institute of medical sciences, 25 singleton pregnancies diagnosed as having preeclampsia and 25 pregnancies without such diagnosis were included in study. Outcome measures: Risk of preeclampsia, pregnancy induced hypertension, preterm birth, small/large for gestational age and child loss. Results:In pre-eclamptic mean triglycerides levels were (254 mg/dl ± 0.45 versus 116.59 ± 4.9) significantly higher than normal controls (p<0.05). Mean HDL-Cholesterol levels were (36.92 mg/dl ± 7.70 versus 51 ± 5.46) statistically significantly higher than normal controls (p<0.05). Mean LDL-Cholesterollevels were(132.95mg/dl ± 32.26 versus 99.36 ± 17.75) statistically significantly higher in pre-eclamptic as compared to normal controls (p<0.05). Conclusion: Pre-eclamptic women had deranged lipid profile as compared to normal pregnant women.
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McGrowder, Donovan, Kevin Grant, Rachael Irving, et al. "Lipid Profile and Clinical Characteristics of Women with Gestational Diabetes Mellitus and Preeclampsia." Journal of Medical Biochemistry 28, no. 2 (2009): 72–81. http://dx.doi.org/10.2478/v10011-009-0007-x.
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Lipid Profile and Clinical Characteristics of Women with Gestational Diabetes Mellitus and Preeclampsia Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy-induced hypertension and other maternal and foetal complications of pregnancy. The aims of the study were to evaluate the serum lipid profile of women with GDM, and determine the number of women with GDM who have preeclampsia (PE). A retrospective study of 84 women with GDM and 90 pregnant women with normal glucose tolerance (controls) was conducted. Women with GDM had significantly higher parity (p=0.047), total cholesterol (p=0.039) and triglycerides (p=0.033), but non-significantly lower HDL-cholesterol (p=0.086) when compared to controls. Systolic blood pressure was significantly elevated in women with GDM coupled with PE (GDM-PE; p=0.015), the mean birth weight of infants born to women with GDM-PE was significantly lower than that of women with only GDM (p=0.025). Women with GDM-PE had significantly higher triglycerides (p=0.020), had to be more multi-gravida (p=0.047) with significantly elevated VLDL-cholesterol (p=0.037) when compared with women with only GDM. 11.9% of women with GDM had PE. On the basis of these findings, it can be concluded that GDM is associated with hyperlipidaemia as evident by the significantly elevated total cholesterol and triglyceride concentrations. Women with dyslipidaemia and GDM are at risk of developing preeclampsia. It is imperative that blood lipids be evaluated in women with GDM during antenatal care as it would be helpful in the early detection and treatment of PE.
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Dev, Kapil, Rajeev Sood, and Aanya Sharma. "Estimation and comparison of serum lipid profile of women with pregnancy induced hypertension and normal pregnancy." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 12 (2019): 4939. http://dx.doi.org/10.18203/2320-1770.ijrcog20195348.
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Background: Hypertensive disorders during pregnancy are the most common medical complication seen during pregnancy, affecting around 5-10% of all pregnancies. Raised blood pressure in pregnancy is the major cause of fetomaternal morbidity and mortality. The most important feature in preeclampsia is hypertension which is supposed to be due to vasospastic phenomenon in kidney, uterus, placenta and brain. Altered lipid synthesis leading to decrease in PGI2:TXA2 ratio is also supposed to be an important way of pathogenesis in pregnancy induced hypertension.Methods: This one-year prospective case control study total 200 pregnant women attending antenatal care and admitted in eclampsia ward fulfiling the inclusion criteria were studied. Serum lipid profile was estimated by semiautomatic analyzers. Statistical analysis of data was done by student’s t-test and p-value.Results: Mean total cholesterol in pregnancy induced hypertension was 278.5±52.52 mg/dl and normal pregnancy was 245.47±20.075 mg/dl. Mean triglycerides in pregnancy induced hypertension was 249.88±92.575 mg/dl and normal pregnancy was 206.89±46.345 mg/dl. Mean HDL in pregnancy induced hypertension was 43.69±4.135 mg/dl and normal pregnancy was 49.9±6.501 mg/dl. Mean LDL in pregnancy induced hypertension was 174.43±39.083 mg/ dl and normal pregnancy was 151.22±19.92 mg/dl. Mean VLDL in pregnancy induced hypertension was 46.885±15.143 mg/dl and in normal pregnancy was 40.964±9.061 mg/dl, total cholesterol, low density lipoprotein, very low density lipoprotein, triglycerides were increased in pregnancy induced hypertension when compared to normal pregnancy, which is statistically significant.Conclusions: We concluded that the Patient who developed pre-eclampsia have abnormal lipid profile. This abnormal lipid profile is responsible for endothelial dysfunction. This endothelial dysfunction may play a key role the pathophysiology of pre-eclampsia. Early detection of these parameters may help patient by preventing complications and is going to aid in better management of pre-eclampsia.
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Masad, Atef. "Assessment of dyslipidemia among hypertensive pregnant women in Gaza Strip." Israa University Journal for Applied Science 1 (October 1, 2017): 17–42. http://dx.doi.org/10.52865/zdrq1624.
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The aim of this study is to assess dyslipidemia status among hypertensive pregnant women and to correlate with preeclampsia in Gaza Strip. A cross sectional study was conducted on 85 pregnant women attending the Gynecology and Obstetrics Department of tertiary care in Gaza Strip (49-hypertension pregnant woman as patients and 36 normal pregnant women without hypertension as a control). Pregnancy induced hypertension (PIH) was found to be associated with fetus sex and it was higher with male fetus 28.6 % and twins 12.2% compared with control. The majority of the PIH patient were obese BMI (32.9 ±4.6) compared with control (25.7±3.5) (P < 0.001). Serum cholesterol, triglycerides, LDL-C, among PIH patients were high (175.3±56.6, 226.9±130.1, 67.4±51.4 mg/dl) respectively, compared with control (143.8±44.1, 186.3 ±101.3, 48.9±46.5 mg/dl) respectively. Abnormal lipid profile and low HDL-C levels may add to the promotion of vascular dysfunction during pregnancy and may induce hypertension and eventually pre-eclampsia and serious complications of fetus.
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Zaidi, Syeda Sabahat Haider, Rukhsana Tumrani, Anber Rahim, Sadia Khalid, Tayyeba Younas, and Dua Ashraf. "Association of hyperuricemia and dyslipidemia in primigravida with preeclampsia during third trimester of gestation at tertiary care hospital." Journal of Rehman Medical Institute 10, no. 2 (2024): 31–35. https://doi.org/10.52442/jrmi.v10i2.840.
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Introduction: It is still difficult to identify women who are more likely to develop preeclampsia, even after decades of research into the condition. Determining whether women are "at-risk" is a crucial goal because a marker that identified high-risk women would enable greater surveillance in secondary care, recruiting for studies of possible therapeutic drugs, accurate diagnosis, and prompt action when issues arise. Predicting preeclampsia in women with underlying medical disorders would also be beneficial for tailored therapy. Objective:To determine the association of hyperuricemia and dyslipidemia with pre-eclampsia in primigravida. Materials & Methods: A descriptive cross-sectional study was conducted in Chemical Pathology section, Sheikh Zayed Hospital, Rahim Yar Khan, from June 15, 2023, to December 16, 2023, on primigravida aged 18-35 years in their third trimester attending OPD and Indoor Gynecology Department of the hospital. Patients with alreadynown diabetes, gestational diabetes mellitus, chronic hypertension, HBV, HIV, chronic obstructive pulmonary disease (COPD), using aspirin, corticosteroids, and antihypertensive medication were excluded. Lipid profile and uric acid were estimated in preeclampsia and normal pregnancy and results compared between the groups. SPSS 23 was used for data analysis and p≤0.05 was taken as statistically significant. Results: Mean serum cholesterol in study subjects with preeclampsia was 260.97±36.74mg/dl, mean serum triglyceride was 248.88 ± 34.55mg/dl, mean serum HDL-c was 37.57 ± 5.17mg/dl, and mean LDL-c was 160.06 ± 27.85mg/dl. The difference of mean serum cholesterol, triglyceride, HDL-c, LDL-c was found statistically significant with p value <0.05. Mean serum uric acid level was found higher in preeclampsia as compared to normal pregnancy with statistically significant difference (p= 0.0001). Conclusion: Hyperuricemia and dyslipidemia were found as significant biochemical abnormalities in females with preeclampsia when compared to normal pregnancy.
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Shiva and Sinha Chitra. "Determining the Correlation between Elevated Levels of High-Sensitivity C-Reactive Protein and Dyslipidaemia in Pregnancy-Induced Hypertension: A Retrospective Study." International Journal of Current Pharmaceutical Review and Research 16, no. 03 (2024): 696–703. https://doi.org/10.5281/zenodo.12795737.
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AbstractAim: To investigate the correlation between elevated levels of high-sensitivity C-reactive protein anddyslipidaemia with the occurrence of pregnancy-induced hypertension.Material and Methods: This retrospective study was conducted in the Department of Obstetrics andGynaecology, Patna Medical College and Hospital, Patna, Bihar, India from January 2020 to December 2020. Thestudy population was 18-35 years old pregnant women after 20 weeks of gestation. Case: Women with pregnancyinduced hypertension with age 18-35 years after 20 weeks of gestation. Case includes-Gestational hypertension,Pre-eclampsia and Eclampsia. Control: Pregnant normotensive women with the same age group and gestation. Asthis study includes more variables so for better statistical results sample size is increased to 60 in each group. 60patients with pregnancy-induced hypertension with age between 18-35 years after 20 weeks of gestation (case).60 pregnant normotensive patients of the same age and gestation (Control).Results: Mean serum total cholesterol (261.13±68.62), serum LDL (183.76±66.51), serum triglycerides (285.98±125.61) and CRP (6.98±4.21) were higher in case compared to that in control (220.46±54.16), (121.90±33.36),(189.03±64.38) and (5.26±2.72) respectively. Mean serum HDL was lower in the case (45.86±15.25) ascompared to that in control (54.06±12.03). All these findings were statistically significant (p≤0.05). Table 6describes the comparison of lipid profile and C-reactive protein among groups-preeclampsia, eclampsia,gestational HTNand normotensive pregnancy, which were statistically significant (p≤0.05). Among the cases58.3% and among controls 31.7% had serum cholesterol ≥ 299 mg/dl and respondents with serum cholesterol ≥299 mg/dl had a 3.02 times more chance to develop pregnancy-induced hypertension which was statisticallysignificant (p=0.003). Among cases 15.0% and among controls 3.3% hadserum HDL < 52mg/dl and respondentswith serum HDL < 52 mg/dl had 5.11 times more chance to develop pregnancy-inducedhypertension which wasstatistically significant (p=0.027). Among cases 61.7% and among controls 11.7% had serum LDL level ≥ 184mg/dl and respondents with serum LDL level ≥ 184 mg/dl had 10.18 times more chance to develop pregnancyinduced hypertension which was statisticallysignificant (p<0.001). Among cases 68.3% and among control 38.3%had serum TG level ≥ 382 mg/dl and respondents with serum TG level ≥ 382 mg/dl had 3.47 times morechance to develop pregnancy-induced hypertension which was statisticallysignificant (p=0.001).Conclusion: In conclusion, based on the results presented in this study we found that high CRP and dyslipidemiawere associated with pregnancy-induced hypertension.
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International, Journal of Medical Science and Advanced Clinical Research (IJMACR). "Vitamin D Level in Preeclampsia and Eclampsia and Its Correlation with Fetomaternal Outcome." International Journal of Medical Science and Advanced Clinical Research (IJMACR) 8, no. 2 (2025): 14–19. https://doi.org/10.5281/zenodo.15239776.
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<strong>Abstract</strong> <strong>Aim: </strong>The aim of the study is to evaluate the levels of vitamin D in pregnant women with preeclampsia and eclampsia and to investigate its correlation with fetomaternal outcomes, including maternal complications and neonatal health parameters. <strong>Materials and methods:</strong> The study included 100 pregnant women beyond 28 weeks of gestation with singleton pregnancies. Women with multiple pregnancies, diabetes, or chronic health conditions were excluded. Routine investigations, including fasting lipid profiles and a 75g glucose screening test (GST), were conducted. Lipid profile thresholds included total cholesterol <200 mg%, triglycerides <150 mg%, HDL 30–70 mg%, LDL <100 mg%, and VLDL 2–30 mg%. Gestational diabetes mellitus (GDM) was diagnosed using the DIPSI criteria (venous glucose >140 mg% post-GST), while pregnancy-induced hypertension, preterm labor, and intrahepatic cholestasis of pregnancy were diagnosed based on standard clinical and biochemical criteria. Statistical analyses were done using SSPS software. <strong>Results:</strong> In the study of 30 healthy pregnant women, 35 preeclamptic women, and 35 eclamptic women, significant differences were observed in gestational age, blood pressure, fetal birth weight, and vitamin D levels. Gestational age at delivery was lower in preeclamptic (36.2±2.5 weeks) and eclamptic women (34.1±2.3 weeks) compared to healthy pregnancies (38.2±2.1 weeks, P<0.002). Both systolic and diastolic blood pressures were significantly elevated in preeclamptic (160/110.2 mmHg) and eclamptic women (160.1/112.3 mmHg) compared to healthy controls (117.2/65.2 mmHg, P<0.002). Fetal birth weights were significantly reduced in preeclamptic (2,112±712.22 g) and eclamptic women (2,654±702.1 g) compared to healthy pregnancies (3,662±621.45 g, P<0.002). Vitamin D levels were also markedly lower in preeclamptic (18.2±3.76 ng/ml) and eclamptic women (19.1±4.01 ng/ml) compared to healthy pregnant women (24.2±5.01 ng/ml, P<0.002). <strong>Conclusion:</strong> The study establishes a significant association between low vitamin D levels and an increased risk of preeclampsia, eclampsia, and adverse fetomaternal outcomes. These findings suggest that vitamin D supplementation may help mitigate these risks, though further research is needed to fully understand its potential role in preventing or managing hypertensive pregnancy disorders.
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Rao, A. Harish. "GLYCEMIC AND LIPIDEIC STATUS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION." Journal of Health and Allied Sciences NU 04, no. 01 (2014): 009–14. http://dx.doi.org/10.1055/s-0040-1703723.
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Abstract: Objective: to know the glycemic and lipidaemic status in patients with acute myocardial infarction, and with the secondary objective to know the effect of age, gender, diabetes, smoking, hypertension on fasting glucose and lipid levels. Methods and materials: The 74 patients admitted for acute myocardial infarction during the study period of one year were analysed for fasting glucose values and serum levels of total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides. Results: The mean serum concentrations of total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol were 233.28±45.34, 139.22±41.71, 171.43±36.53 and 27.07±36.53 respectively. Mean levels of total cholesterol, HDL cholesterol, triglycerides and fasting glucose values were not affected by age, gender, BMI, hypertension and smoking. BMI >30kg/m2 was associated with increased levels of total cholesterol(p=0.013) and LDL cholesterol(p=0.014). Also increase LDL cholesterol was seen in male gender(p=0.04). The prevalence of hypercholesterolemia, hypertriglyceridemia and low HDL cholesterol was 82.4%,77% and 78% respectively. Diabetes had no effect on lipid profile. Conclusion: our study highlighted the prevalence of dyslipidemias associated with myocardial infarction but not significant impact of fasting glucose levels.
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Harpreet, Bajwa Sharma, and Punia Nikky. "Comparative Assessment of Lipid Profile in Pre-Eclampsia." International Journal of Pharmaceutical and Clinical Research 16, no. 5 (2024): 934–36. https://doi.org/10.5281/zenodo.11429198.
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Pre-eclampsia is common medical complication of pregnancy. The association of altered lipid profile in essential hypertension is well documented. The present study was planned to study the role of altered lipid profile in the development of pre- eclampsia. <strong>Methodology:</strong> The study comprised of 30 normal pregnant women and 30 pre-eclamptic women in their third trimester of pregnancy. Serum Total cholesterol, Triglycerides, LDL Cholesterol and HDL- Cholesterol by enzymatic colorimetric method were done. <strong>Results:</strong> There was significant rise in Serum Total cholesterol, Triglycerides, LDL Cholesterol and a significant decrease in HDL Cholesterol in pre-eclamptic group as compared to normal healthy pregnant women. <strong>Conclusion:</strong> Altered lipid profile also has a potential role in the genesis of endothelial dysfunction and expression of pre-eclampsia. Early detection of these parameters may help patient by preventing complications in pre-eclampsia and is going to aid in better management of Pre-eclampsia.
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Falbová, Darina, Lenka Vorobeľová, Veronika Candráková Čerňanová, Radoslav Beňuš, and Daniela Siváková. "Association of Leu432Val (rs1056836) polymorphism of the CYP1B1 gene with lipid profile in hypertensive Slovak women." Anthropological Review 85, no. 2 (2022): 1–12. http://dx.doi.org/10.18778/1898-6773.85.2.01.
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Leu432Val (rs1056836) polymorphism of the CYP1B1 gene was examined in relationship with lipid profile in hypertensive Slovak women according to their menopausal status. The entire study sample comprised 255 women suffering from hypertension aged from 39 to 65 years who were recruited from different localities in the western, southern, and middle parts of Slovakia. The participants provided a saliva or blood sample for DNA genotyping and a blood sample for biochemical analysis. The Leu432Val genotypes demonstrated statistically significant associations with all monitored atherogenic indices – total cholesterol-to-HDL-Cholesterol (AI1), Non-HDL-Cholesterol (AI2), LDL-Cholesterol-to-HDL-Cholesterol (AI3), and the logarithm of the ratio of plasma concentration of triglycerides to HDL-cholesterol (AIP log) in hypertensive pre/perimenopausal women. The mean values were significantly lower in women carrying the Val/Val genotype. In early postmenopausal hypertensive women the Leu432Val genotypes were statistically significant and associated with LDL-cholesterol (LDL-C) and AI2. The mean values of LDL-C and AI2 were significantly lower in women carrying the Leu/Leu genotype. In conclusion, the Leu432Val polymorphism may be associated with the atherogenic indices and LDL-C in hypertensive women.
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JAYWANT, Deshpande Janhavi, Amit BHALERAO, Vikas RATNAPARKHI, et al. "Lipid Profile of the Patient with Acute Coronary Syndromes Undergoing Coronary Angiography (CAG) in Rural Costal Region of Maharashtra." Medicina Moderna - Modern Medicine 28, no. 4 (2021): 397–400. http://dx.doi.org/10.31689/rmm.2021.28.4.397.
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Background: Coronary Heart Disease (CHD) is widely prevalent across the globe and significantly high level of Cholesterol in circulation is a single major risk factor associated with coronary heart disease. It is well established that cardiovascular disease is associated with hypertension and elevated blood levels of low-density lipoprotein (LDL), total cholesterol, and triglycerides. In disparity, a low level of high-density lipoprotein (HDL) is a risk factor for mortality from cardiovascular disease. Aim: The present study was conducted with the aim to assess the lipid profile in patients of Acute Coronary Syndrome (ACS) undergoing coronary angiography (CAG) in rural coastal population. Patients and Methods: The present study was done on 62 patients with Acute Coronary Syndrome (ACS) undergoing coronary angiography (CAG) Serum levels of total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides were examined in biochemical laboratory of the hospital. Coronary angiography was performed for the presence of lesions. Results: 43.5% of the patients (n=27) were elderly (age>60 years). Approximately 82% of the patients (n=51) aged more than 50 years. Males outnumbered females with a ratio of 2.4:1. 71% of the patients were males. Mean cholesterol levels were 177.86 mg/dl. Approx 3/4th of the patients (n=41) had cholesterol level <200 mg/Dl. Mean triglycerides levels in the patients were 158.29 mg/dl. Only 11 patients out of 62 CAD patients had abnormal triglycerides. Mean LDL level was 119.5 mg and Mean HDL level was 34.5 mg %. The high plasma concentration of low-density lipoprotein (LDL-C) in 30% and the low plasma concentration of high-density lipoprotein (HDL-C) n 33% of patients were important abnormal findings in our patients. Conclusion: Dyslipidemia as in form of very low levels of HDL cholesterol with comparatively high levels of LDL-c with near normal total Cholesterol and triglyceride levels associated with ACS in our rural costal region of Maharashtra.
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McKenney, James M. "Understanding and Treating Dyslipidemia Associated With Noninsulin‐Dependent Diabetes Mellitus and Hypertension." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 13, no. 4 (1993): 340–52. http://dx.doi.org/10.1002/j.1875-9114.1993.tb02741.x.
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Hypertension and diabetes appear to increase coronary heart disease risk in part by causing an abnormality in lipid metabolism. Most affected are patients with familial dyslipidemic hypertension (FDH) and noninsulin‐dependent diabetes mellitus (NIDDM). The lipid disorders most often encountered in these patients are increased levels of triglycerides, very low‐density lipoprotein (VLDL) cholesterol, and small, dense low‐density lipoprotein (LDL) cholesterol, and low levels of high‐density lipoprotein (HDL) cholesterol. These abnormalities appear to result from increased hepatic secretion of VLDL particles due to increased concentrations of free fatty acids and glucose, reduced VLDL clearance due to reduced activity of lipoprotein lipase, and reduced LDL clearance due to glycosylation of ligand proteins. Treatment of the dyslipidemia associated with FDH should follow the guidelines from the National Cholesterol Education Program. Treatment in men and women with NIDDM should be considered when LDL cholesterol levels are 130 mg/dl or above, triglyceride levels are 200 mg/dl or above, or non‐HDL cholesterol levels are 160 mg/dl or greater. Aggressive lifestyle changes should be initiated first, including weight loss in obese patients, control of glucose levels in those with NIDDM, avoidance of antihypertensive drugs that may worsen lipid levels in patients with FDH, and eating a diet restricting saturated fat and cholesterol. Addition of lipid‐altering drugs should be considered if such changes do not achieve effective lipid control. The agent should be tailored to the patient's lipid profile, in general by using bile acid resins, niacin, or reductase inhibitors to lower LDL cholesterol and gemfibrozil or niacin to lower triglycerides. Niacin should be avoided in patients with NIDDM.
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Rafaqat, Saira, Sana Rafaqat, and Aleksandra Klisić. "The role of serum lipid profile in the pathogenesis of arterial hypertension." Arhiv za farmaciju 74, no. 1 (2024): 76–91. http://dx.doi.org/10.5937/arhfarm74-47908.
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Hypertension is a key contributor to the high global burden of cardiovascular morbidity and mortality, due to its increasing prevalence worldwide. In clinical practice, dyslipidemia and hypertension often coexist, possibly because they share similar underlying causes, such as endothelial dysfunction and obesity. Consequently, this review article presents the collective findings on the role of lipid profile parameters in arterial hypertension. Individuals with hypertension often have significantly higher mean serum levels of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C), while exhibiting lower mean serum levels of high-density lipoprotein cholesterol (HDL-C) compared to those without hypertension. TC and HDL-C play an important role in the pathogenesis of arterial hypertension. However, there is a lack of studies explaining the link between TG and LDL-C and arterial hypertension. Future studies are necessary to fully elucidate the exact mechanisms by which the mentioned lipid parameters contribute to arterial hypertension.
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Chandra, Shruti, S. P. Singh, Rashmi Singh, and Neeraj Kumar Agarwal. "Effect of lisinopril and perindopril on serum lipid profile in Albino rabbits." International Journal of Basic & Clinical Pharmacology 7, no. 6 (2018): 1136. http://dx.doi.org/10.18203/2319-2003.ijbcp20182095.
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Background: Hypertension with dislipidemia is becoming a common morbidity, since ACE inhibitors are the first line of antihypertensive drugs so present study was undertaken with the aim to evaluate the possible effects of ACE inhibitor on lipid profile in albino rabbits.Methods: The study was conducted in the Department of Pharmacology and Therapeutics, GSVM Medical College, Kanpur. Rabbits were divided into 2 groups with 6 in each group. Rabbits of Group I was given Lisinopril in dose of 0.25mg/kg and of group II was given Perindopril in dose of 0.20mg/kg for a period of 6 weeks. Lipid profile estimation (Serum Total cholesterol, serum HDL, serum LDL, serum Triglycerides and serum VLDL) was done at day 0, 7, 21 and 45 respectively.Results: After analysis Rabbits of group-I (Lisinopril) showed 3.1% decrease in serum cholesterol level at 45th day (P<0.001). Serum HDL level increased by 6.4% and 14.3% at day 21 and 45 respectively (P<0.05). Increase in serum Triglyceride level was 2.6% at day 45 (P>0.05). Serum LDL level decreases by 4.4% and 8.6% at day 21 and 45 respectively (P<0.001). There was no significant change in Serum VLDL level. Rabbits of group- II (Perindopril) showed decreased total cholesterol levels by 2.6% (P<0.05). There was an increase in HDL level by 6.8 % at day 45(P<.05). Triglycerides and VLDL levels were not significantly altered while serum LDL level decreases by 6.7% at day 45 (P<0.01).Conclusions: From our study it was concluded that Lisinopril had a favourable effect on serum lipid profile by decreasing total cholesterol, increasing serum HDL level. It may increase triglycerides, decrease LDL. Perindopril increase serum HDL and decreases LDL, there is no significant change in cholesterol, TG and VLDL levels.
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Khalid Moufak, Shaimaa, Rowshen Hani Al Nakeeb, and Tamara Sami Naji. "Estimation of Some Biochemical Tests in the Serum of Obese Men with Normal Blood Pressure and High Blood Pressure." Sumer 4 8, CSS 4 (2023): 1–5. http://dx.doi.org/10.21931/rb/css/2023.08.04.25.
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Obesity is a medical word that refers to a state in which a person's body fat levels are excessively high. Obesity is linked to a variety of health issues in humans, like the emergence of hypertension. This study aimed to look at the blood glucose concentration, urea, creatinine, and lipid profile factors in obese and hypertension-overweight men's sera. The study included 75 people who were evenly divided into three groups: healthy controls, normotensive obese people, and hypertension-obese people. When comparing obese males to controls, there was a significant increase (P<0.01) in blood glucose, urea, creatinine, cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C) although only triglycerides (TGs) and VLDL-C were substantially different in hypertension obese versus normotensive obese. Compared to controls, Obese men had significantly lower levels of high-density lipoprotein cholesterol (HDL-C). High levels of triglycerides (TGs) and Very Low-density Lipoprotein cholesterol (VLDL) in hypertensive obese males show they play a role in hypertension problems. Keywords: Obesity, Hypertension, Urea, Creatinine, lipid profile.
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Gawande, Madhuri Sushil, and Sulabha Avinash Joshi. "Lipid profile in patients of preeclampsia: A comparative study." Panacea Journal of Medical Sciences 6, no. 3 (2016): 155–58. https://doi.org/10.18231/2348-7682.2016.0010.
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Preeclampsia occurs in 7 to 10% of pregnancies worldwide. At present most popular theory is an oxidative stress. Abnormal lipid profiles and species may have a role in promotion of oxidative stress and vascular dysfunction seen in pre-eclampsia. The study was carried out to evaluate lipid profile in subjects with preeclampsia and to compare lipid profile in subjects of preeclampsia as compared to normal pregnant women from 26 weeks of gestation till term. Pregnant women with and without preeclampsia between 26weeks-till term were compared for serum total cholesterol, triglycerides(TG), low density lipoprotein(LDL), high density lipoprotein (HDL) and very low density lipoproteins(VLDL). The study was conducted in tertiary care hospital over a period of one year. The total serum cholesterol, triglycerides, LDL and VLDL was significantly raised in subjects with preeclampsia as compare to pregnant women without preeclampsia. Considering the results in this study correlating with the various other studies, it can be concluded that dyslipidemia is significantly evident in preeclampsia and plays an important role in its pathogenesis. The preventive measures taken to avoid dyslipidemia like dietary control, weight reduction and physical activity and its positive effect on pregnancy needs to be further studied.
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Saihood, Sumaya T. "Early-Pregnancy Changes in Maternal Lipid Profile in Women with Recurrent Preeclampsia and Women with Normal Pregnancy." Journal of the Faculty of Medicine Baghdad 59, no. 2 (2017): 128–31. http://dx.doi.org/10.32007/jfacmedbagdad.592122.
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Background: “According to the current knowledge, changes in lipid profile in pregnancy is a major contributor in the pathogenesis of preeclampsia. The present study was designed to compare the changes in lipid profile in normal pregnancy and in patients with history of recurrent pre-eclampsia (PE).”Objective: Assessment the relationship between lipid profiles changes in women with history of recurrent preeclampsia in comparison to normal pregnancy in early pregnancy.Patients and Methods: Measurement of lipid profile changes in women with history of recurrent preeclampsia (more than two preeclampsia in previous pregnancies) at 12 to 16 weeks of pregnancy and compared to normal pregnancy as a control group who does not have history of preeclampsia also early in pregnancyResults: The patients with history of recurrent Preeclampsia had significantly higher mean total cholesterol level compared to controls (216.1 ± 25.5 mg/dl) and (195.6 ± 23.2 mg/dl), respectively, (P<0.05).The mean HDL cholesterol (HDL-C) level was significantly lower in PE group (49.3 ± 9.2 mg/dl) than controls (52.2 ± 8.4 mg/dl), (P<0.05). The mean level of LDL cholesterol was (122.3 ± 28.7) mg/dl in PE group and it was significantly higher than the (108.6 ± 26.8 mg/dl) of controls, (P<0.05). Similarly, the mean VLDL cholesterol was also higher in women with history of recurrent preeclampsia than control group, (44.8 ± 12.6) vs. (34.8 ± 7.3) mg/dl, respectively, (P<0.05). The Triglycerides (TG) was also elevated in women with history of recurrent preeclampsia where the mean TG level was (224.2 ± 63.1 mg/dl) compared to (174.6 ± 36.3mg/dl) in controls, (P<0.05).Conclusion: “This study showed that the women who have history of recurrent preeclampsia had disturbed lipid profile (increased levels of total TC, TG, VLDL-C and LDL-C concentration) in addition to decrease the high density lipoprotein cholesterol (HDL-C) level in subsequent pregnancy compared to normal pregnancy.”
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Waseem, Shahid, Zain Ul Abideen, Fatima Saadat, et al. "Lipid Profile in PTS of Type 02 Diabetes Mellitus with & without Hypertension." Pakistan Journal of Medical and Health Sciences 16, no. 6 (2022): 691–93. http://dx.doi.org/10.53350/pjmhs22166691.
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Introduction: Diabetes causes hyperglycemia, glucose, lipid, and protein metabolic issues owing to insufficient insulin production or activity resulting in dyslipidemia and hypertension. Dyslipidemia raises triglycerides, free fatty acids, and serum HDL cholesterol, causing cardiovascular events including high blood pressure. Objective: The current study aimed to evaluate the serum lipid profiles of type 02 diabetics with and without hypertension. Study layout The research strategy is experimental, using a comparative study method. Methodology: Mercy Teaching Hospital and Prime Hospital, Peshawar, performed the study. 6-month research. Peshawar's Prime and Mercy Teaching Hospitals conducted lab tests from July to December 2021. Descriptive-analytic research was our objective. Cases and controls were chosen among 200 type 02 diabetics. Cases comprised type 02 diabetics with hypertension; controls had none. Blood cholesterol, triglyceride, LDL, and HDL were measured. Statisticians utilised SPSS 24. Comparing groups' means using a student T-test. Result: Patients averaged 51.33 6.35 years old. Our patients were mostly 41-50. 82 (41%) men and 112 (59%) women participated in our research. Mean blood cholesterol, triglycerides, and low-density lipoprotein (LDL) values in cases and controls were 211.40 101.64 mg/dL vs 158.88 31.84 mg/dL, 307.95 167.17 mg/dL vs 154.39 59.12 mg/dL, and 115.57 82.26 mg/dL vs 94.40 Serum cholesterol, triglyceride, and LDL values were significant (p0.01). Serum HDL in controls (44.23 6.41mg/dL) was greater than in controls (41.13 4.96mg/dL) but not statistically significant (p-value > 0.05). Conclusion: Our study found that hyperlipidemia is common in type 2 diabetes mellitus patients with hypertension, However the mechanism of this connection is uncertain. Keywords: Diabetes mellitus type 2 , Dyslipidemia, hypertension, Peshawar, Pakistan
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ATOE, Kenneth, and Ejuoghamran Oriseseyigbemi ONOVUGHAKPO-SAPKA. "Lipid ratios improve early detection of atherosclerotic cardiovascular disease in women with hypertensive disorders in pregnancy." Journal of Experimental and Clinical Medicine 39, no. 2 (2022): 353–58. http://dx.doi.org/10.52142/omujecm.39.2.9.
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In a normal healthy pregnancy, increased lipid profiles help to encourage fetal development, but in hypertensive disorders in pregnancy, these changes in lipid profiles are amplified, which may predispose these women to atherosclerotic cardiovascular disease. The study's aim was to determine the alteration in lipid profile levels of women with hypertensive disorders in pregnancy and also calculate their atherogenic risk ratios, with the view to improving the predictive capacity of the lipid assay for the risk of arteriosclerosis and cardiovascular incidence. This study enlisted 190 participants, which included 124 pregnant women with preeclampsia, 30 pregnant women with pregnancy-induced hypertension, and 36 pregnant women with normal blood pressure who served as controls. Lipid profile was determined via the enzymatic method from blood samples obtained from the participants. When compared to normotensive control study participants, patients with hypertensive disorders in pregnancy had a slight increase in total cholesterol and LDL cholesterol, as well as a substantial difference in triglyceride levels. Despite minor increases in total and LDL cholesterol levels, the case group's mean atherogenic index plasma, atherogenic coefficient, and Castelli risk index I and II were all higher than the control group's. Individual lipid parameter measurements were found to be ineffective in evaluating the relative contribution of lipids to cardiovascular risk in pregnant patients with hypertensive disorders. Lipid ratios, also known as atherogenic indices, were found to be more effective in assessing the relative contribution of lipids to cardiovascular risk.
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Putranti, Widyasari, Lina Widiyastuti, Moch Saiful Bachri, and Defianti. "Test Activity Combinations of Celery Herb (Apium graveolens L.) and Bay Leaf (Syzygium polyanthum W.) Ethanol Extract Toward DecreasedLipid Profile Levels in Hypertensive Mice." Advanced Materials Research 1162 (April 2021): 166–72. http://dx.doi.org/10.4028/www.scientific.net/amr.1162.166.
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Celery herb contains flavonoid which can hamper cholesterol synthesis through inhibitor HMG-CoA reductase. Bay leaf has a working mechanism that stimulates bile fluid secretion and stimulates blood circulation. This research aims to know the activity combinations of bay leaf ethanol extract (BLEE) and celery herb ethanol extract (CHEE) and to know which dose mostly can decrease lipid profile levels. The design of this research uses experimental with pre-post control group design. The mice are rendered with NaCl 8% solution and High Fat Feed. The mice are divided into 9 groups, in each group there are 5 mice which are normal group, control group, HCT group, Simvastatin group, and CHEE 4.50 mg/kgBW, BLEE 25.00 mg/kgBW, combination 1, combination 2, and combination 3. Data analysis is conducted with Normality test, One Way ANOVA test, Kruskal-Wallis, Mann-Whitney. Based on the research after they are induced with NaCl 8% solvent and given high-fat feed, the extract can increase total cholesterol levels, triglycerides, LDL, and also significantly decrease HDL (p <0.05). After giving a test extract solution, it can reduce total cholesterol, triglycerides, LDL, and also significantly increase HDL levels (p <0.05). The conclusion, the three variations combinations dose can decrease total cholesterol, Triglycerides, LDL, and also increase HDL levels, and combination dose 3 has the greatest decrease in total cholesterol, triglyceride, LDL, and the highest increase in HDL levels. So the lower the total cholesterol level, the lower the possibility of hypertension.
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Pawar, Satish Ambadas. "Comparison of lipid profile in physically trained adults and sedentary adults." International Journal of Bioassays 6, no. 8 (2017): 5465. http://dx.doi.org/10.21746/ijbio.2017.08.004.
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The incidence of diseases like angina pectoris, myocardial infarction, hypertension and cerebrovascular is increasing nowadays. The high blood lipid level is found to be the main cause of atherosclerosis. Present study is undertaken with the aim to evaluate the effect of physical training on BMI, Waist-hip ratio and lipid profile. Our research is focussed to study the Effect of Physical Training on Serum Lipids in physically trained adults and sedentary adults. To compare lipid profile between physically trained adult and sedentary adult. The study was conducted on 50 male physically trained adults and 50 male sedentary adults in the age group between 30-40 years. Following parameters were evaluated: Total cholesterol, Triglycerides, HDL, LDL and VLDL. There is statistically highly significant decrease in BMI, Waist-hip ratio, total cholesterol, triglycerides, LDL- C, VLDL- C, and highly significant increase in HDL- C in physically trained adults as compared to sedentary adults. From the results, it is concluded that combination of aerobic exercise and games causes highly significant decrease in total cholesterol, TG, LDL- C, VLDL-C and increase in HDL-C. Thus, combination of aerobic exercise and games is more beneficial instead of only aerobic exercise and hence should be recommended.
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Imawati, Hening. "Overview of Glucose Levels, Blood Pressure, and Lipid Profiles in Patients with Prolanis DM Hypertension." Jaringan Laboratorium Medis 2, no. 2 (2021): 61–67. http://dx.doi.org/10.31983/jlm.v2i2.7066.
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The Primary Clinic of UKSW is one of the FKTP BPJS Health implementing service program of chronic disease (Prolanis). Patients with screening of one time blood glucose 200 mg/dL or fasting blood sugar 126 mg/dL were included in control patients of DM prolanis. Patients with criteria of pre hypertension and hypertension 1 were included in the control patients of hypertensive prolanis. Patients with DM and hypertension may have level of high lipid profile so laboratory tests are needed to prevent complications, including cholesterol, HDL, LDL and triglycerides. Research objective to find out the description of glucose level, blood pressure, and lipid profile in patients of DM hipertension prolanis at the Primary Clinic of UKSW Salatiga. The research type was descriptive. The research data was primary data by measuring blood pressure, blood glucose levels and lipid profile. Research results normotension 16 (30,2%), pre hypertension 20 (37,70%), and first degree hypertension as many as 17 (32,10%). The glucose levels of normal blood 20 (37,74%), normal 33 (62,26%). The profile levels of normal lipid cholesterol 30 (54,72%), HDL 26 (49,06%), LDL 9 (18,98%), and triglyceride 30 (56,60%). The profile levels of abnormal lipid cholesterol 29 (45,29%), HDL 27 (50,95%), LDL 44 (83,02%), and triglyceride 23 (43,40%). The glucose levels of normal blood 20 (37,74%) in normotension 5 (9,4%), pre hypertension 8 (15,09%), and first degree hypertension as many as 7 (13,21%). Blood glucose levels normal 62,3% in normotension 11 (20,8%), pre hypertension 12 (22,64%) and first degree hypertension as many as 10 (18,87%).
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Datta Banik, Sudip. "Interrelationships between Blood Pressure and Lipid Profile Characteristics among Postmenopausal Women at Naxalbari in Darjeeling, West Bengal." Collegium antropologicum 46, no. 2 (2022): 113–20. http://dx.doi.org/10.5671/ca.46.2.5.
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Objective of the present study was to find association between blood pressure and lipid profile characteristics in postmenopausal women. A cross-sectional study was done in 2015 at Naxalbari in Darjeeling district of West Bengal, India. The sample included 129 postmenopausal women aged between 40- and 55-years, representing Dhimal community. Blood pressure (systolic and diastolic) was recorded and levels of triglycerides (TG), high-density lipoprotein cholesterol (HDLC), and low-density lipoprotein cholesterol (LDL-C) were estimated. Derived lipid profile parameters were total cholesterol, non-HDL-C, Castelli Risk Index (CRI) I and II, atherogenic coefficient, and atherogenic index of plasma (AIP).Hypertension (systolic/diastolic 140/90 mmHg), hypertriglyceridemia (≥150 mg/dL), high LDL-C (≥130 mg/dL), and low HDL-C (&lt;50 mg/dL) were diagnosed. Correlation and binomial logistic regression analyses were done to find the association between variables. Mean values of age and age at menopause were 50.34 years and 45.36 years, respectively. Prevalence of hypertension (65.89%), hypertriglyceridemia (21.71%), high LDL-C (43.41%), and low HDL-C (48.06%) were remarkable in the sample. Binomial logistic regression models after adjusting for age, showed that lipid parameters (TG, non-HDL-C, and AIP) significantly predicted hypertension. AIP was observed to be the best predictor of hypertension (Youden index = 0.52) and odds ratio showed that one unit increase in AIP had a chance of 24% rise in odds of having hypertension. Hypertensive postmenopausal women had higher mean values and prevalence of abnormal lipid profile characteristics. Age at menopause had significantly negative association with blood pressure and lipid profile parameters.
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Babu, S. Vinod, Anusha R. Jagadeesan, and Jothimalar Ramalingam. "A Comparative Study of Lipid Profile in Obese and Nonobese Men attending Master Health Checkup." Indian journal of Medical Biochemistry 21, no. 2 (2017): 73–75. http://dx.doi.org/10.5005/jp-journals-10054-0024.
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ABSTRACT Introduction Obesity is emerging as an epidemic worldwide. Obesity is associated with a number of comorbid conditions, such as diabetes mellitus, hypertension, cancer, dyslipidemia, cardiovascular abnormalities, anemia, obstructive sleep apnea, and psychosocial abnormalities. Aim This study aims at comparing the lipid profile levels of obese and nonobese men. Materials and methods This was a case—control study conducted at a tertiary care center. Totally, 80 men in the age group of 20 to 47 years attending the master health checkup were included in the study, out of which 40 men with normal body mass index (BMI) of 18 to 25 belonged to group I and 40 men with increased BMI of 30 and above belonged to group II. Lipid profile parameters, such as triglycerides (TGLs), total cholesterol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol were estimated in them. The data were statistically analyzed using Statistical Package for the Social Sciences (SPSS) software version 15.0. Results Statistically significant difference was found in the total cholesterol levels with a p-value of 0.040 while the difference in LDL cholesterol was statistically highly significant with a p-value of 0.040. Conclusion Among lipid profile parameters, only total cholesterol and LDL cholesterol showed significant difference between the obese and nonobese individuals. However, the other parameters like HDL cholesterol and TGLs did not show any significant difference. How to cite this article Babu SV, Jagadeesan AR, Ramalingam J. A Comparative Study of Lipid Profile in Obese and Nonobese Men attending Master Health Checkup. Indian J Med Biochem 2017;21(2):73-75.
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Belyaeva, O., E. A. Bazhenova, A. V. Berezina та ін. "Adiponectin levels, lipid profile and glucose metabolism in patients with abdomi-nal obesity". "Arterial’naya Gipertenziya" ("Arterial Hypertension") 15, № 3 (2009): 309–13. http://dx.doi.org/10.18705/1607-419x-2009-15-3-309-313.
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Adiponectin levels, lipid profile and parameters of glucose metabolism were evaluated in patients with abdominal obesity. It was found that adiponectin level negatively correlated with body mass index (BMI). The significant correlations were found between levels of adiponectin, triglycerides, and high-density lipoprotein (HDL) cholesterol in patients with abdominal obesity. Patients with abdominal obesity and arterial hypertension had higher levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides comparing to non-hypertensive patients with abdominal obesity. BMI increase positively correlated with insulin level and insulin resistance index estimated by homeostasis model assessment (HOMA-IR). Positive correlations were also determined between HOMA-IR and waist circumference, BMI, and adiponectin level.
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Chopra, Sheena, and Sangeeta Pahwa. "Role of lipid profile and uterine artery doppler in predicting risk of preeclampsia in early second trimester." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 5 (2020): 1806. http://dx.doi.org/10.18203/2320-1770.ijrcog20201542.
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Background: Preeclampsia is associated with adverse pregnancy outcome and is a major cause of the fetomaternal morbidity and mortality. This study aimed at finding the role of lipid profile and uterine artery Doppler as a reliable predictor of risk of preeclampsia in early second trimester.Methods: This study is conducted in the obstetrics and gynecology department of a tertiary care teaching hospital, Amritsar. Lipid profile and Uterine artery doppler is estimated in 100 antenatal women from 14-20 weeks of period of gestation who met the inclusion criteria and are followed up till delivery or till preeclampsia sets in.Results: Out of 100 subjects 74 remained normotensive (Group A) and 26 developed preeclampsia (Group B). The mean serum level of total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL) and very low-density lipoprotein cholesterol (VLDL) was significantly higher in Group B as compared to group A women. The Preeclamptic women showed significant fall in high density lipoprotein cholesterol (HDL) level as compared to normal pregnant women. The mean S/D ratio, PI and RI values of uterine artery Doppler were higher for group B and were statistically significant.Conclusions: The combined predictive value of lipid profile and uterine artery Doppler for estimating risk of preeclampsia was more reliable than of any of the test individually.
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Matwiejuk, Mateusz, Hanna Mysliwiec, Olivia Jakubowicz-Zalewska, Adrian Chabowski, and Iwona Flisiak. "Effects of Hypolipidemic Drugs on Psoriasis." Metabolites 13, no. 4 (2023): 493. http://dx.doi.org/10.3390/metabo13040493.
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Psoriasis is a chronic, systematic, inflammatory disease in which multiple metabolic and immunologic disturbances lead to lipid abnormalities, impaired glucose tolerance, metabolic syndrome, diabetes mellitus, atherosclerosis, hypertension, ischemic heart disease, and numerous metabolic disorders. In clinical practice, the most commonly used drugs in the treatment of lipid abnormalities are statins and fibrates. Statins are characterized by pleiotropic effects such as antioxidant, anti-inflammatory, anticoagulant, and antiproliferative. They work by reducing the concentrations of low-density lipoprotein (LDL), total cholesterol, and triglycerides and stabilizing atherosclerotic plaque. Fibrates are medications, which help to lower triglycerides, LDL, very low-density lipoprotein (VLDL) levels and increase lower high-density lipoprotein (HDL). In recent years, many new drugs were found to normalize the lipid profile in patients with psoriasis: glitazones (pioglitazone, troglitazone), and glucagon-like peptide-1 (GLP-1) receptor agonists. Pioglitazone improves the lipid profile, including the decrease of triglycerides, fatty acids, and LDL, as well as the increase of HDL. Glucagon-like peptide 1 (GLP-1) analogs decrease modestly low-density lipoprotein cholesterol (LDL-C), total cholesterol, and triglycerides. The purpose of this study is to assess the current state of knowledge on the effect of different hypolipidemic treatments on the course of psoriasis. The study includes literature from medical databases PubMed and Google Scholar. We were browsing PubMed and Google Scholar until the beginning of December. The systematic review includes 41 eligible original articles.
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Iqbal, M., M. Asif Shahab, Mohsin Ali Hassni, Sana Dur Muhammad, Shehroz Bashir, and Shah Murad. "Caffeic Acid, Chlorogenic Acid, Garlic Acid, and Protocatechuic Acid as Hypolipidemic Agents." SAR Journal of Pathology and Microbiology 4, no. 06 (2023): 82–85. http://dx.doi.org/10.36346/sarjpm.2023.v04i06.005.
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As the pathophysiology of dyslipidemias is clarified, one system is likely to emerge in which the underlying mechanism explains the phenotypic pattern observed on lipoprotein analysis. Every day, millions of vials of blood are drawn to assess patients’ risk for the disease. These tests measure three biomarkers, or factors in the blood known to be associated with CAD: low-density lipoproteins (LDL cholesterol), high-density lipoproteins (HDL cholesterol), and triglycerides. All three biomarkers are lipids – water-insoluble molecules that are among the structural and functional building blocks of living cells. Highly altered Body Mass Index (BMI) and hypertension are independent and reversible determinants for coronary artery disease. Hypolipidemia can prevent hyperlipidemic patients to be victim of coronary artery disease. This study was conducted to compare hypolipidemic effects of Niacin and Jujube fruit in primary as well as secondary hyperlipidemic patients. Study was conducted in 2023 at Jinnah Hospital Lahore, Pakistan. Sixty participants were enrolled of both gender male and female hyperlipidemic patients age range from 20 to 70 years. Written and explained consent was taken from all patients. They were divided in two groups. Group-I was advised to take two grams Niacin in divided doses for the period of two months. Group-II was advised to take 500 grams of fruit Jujube daily for the period of two months. Their baseline LDL and HDL cholesterol was determined by conventional method of measuring Lipid Profile. After two months therapy, their post treatment lipid profile was measured and mean values with ± SEM were analyzed biostatistically. Group-I which was on Niacin their LDL cholesterol decreased significantly and HDL cholesterol was increased significantly. In group-II patients LDL cholesterol was decreased significantly but HDL increase was not significant with p-value of >0.05. It was concluded from the research work that Niacin is potent in lowering LDL and increasing HDL cholesterol, while Jujube has significant effect as LDL cholesterol lowering agent, but it does not increase HDL cholesterol significantly.
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Manish, Kumar. "A Hospital-Based Study Assessing Relationship between Glycated Hemoglobin (Hba1c) and Lipid Profile Components in Newly Diagnosed T2DM Patients." International Journal of Current Pharmaceutical Review and Research 15, no. 09 (2023): 268–72. https://doi.org/10.5281/zenodo.11656751.
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AbstractAim: The aim of the present study was to find the relationship between Glycated hemoglobin (HbA1c) and lipidprofile components in newly diagnosed T2DM patients.Material & Methods: In the study, 50 newly diagnosed type 2 diabetes patients were included as cases and 50non-diabetic subjects were included as controls. Blood samples were collected from the subjects of both thestudy and control groups and were analysed for fasting and post-prandial plasma glucose, HbA1c, TC, TG,LDL-C, and HDL-C. 84% of cases had dyslipidemia whereas only 52% of controls were found to havedyslipidemia and the difference between the two groups was statistically significant (p<0.05).Results: 84% of cases had dyslipidemia whereas only 54% controls were found to have dyslipidemia and thedifference between the two was statistically significant (P < 0.05). The difference of mean age between twogroups was not statistically significant (p> 0.05). Statistically significant difference (p<0.05) was found whenthe mean values of HbA1c, FBS, PPBS, S. Total Cholesterol, S. Triglycerides, LDL-C, HDL-C of cases andcontrol groups, were compared. The frequency of raised blood sugar parameters (HbA1c>6.5, FBS>126mg/dl,PPBS>200mg/dl) and dyslipidemia (S. Cholesterol-total, S. Triglycerides, LDL-C, HDL-C) in cases and controlgroups were noted. The statistically significant (p<0.05) difference was found between the two groups, whencompared. A significant positive correlation was found between glycemic parameters (HbA1c, FBS and PPBS)and lipid profile parameters (Serum Triglyceride, Serum Total Cholesterol, Serum LDL Cholesterol) withp<0.05. But insignificant correlation was found with Serum HDL-Cholesterol (p>0.05).Conclusion: Significant positive correlation of HbA1c with lipid profiles in our study suggests that HbA1c canalso be used as a predictor of dyslipidemia in addition to a glycemic control parameter for prevention ofcomplication. Furthermore, HbA1c shows a significant correlation with TC, TG, LDL, and VLDL, whereas ithas a significant negative correlation with HDL. The study showed thatHbA1c might be useful for predictingdyslipidemia in T2DM patients
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Kapustin, Roman V., Elizaveta M. Tsybuk, Elena N. Alexeyenkova, et al. "The role of dyslipidemia in the pathogenesis of perinatal complications in pregnant women with diabetes mellitus." Journal of obstetrics and women's diseases 70, no. 1 (2021): 89–100. http://dx.doi.org/10.17816/jowd48566.
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Hypothesis/Aims of study: The prevalence of diabetes mellitus in pregnant women is increasing. Physiological hyperlipidemia is usually developed during the last third of gestation, increases during pregnancies complicated by diabetes mellitus. Abnormal lipid profiles are associated with adverse perinatal outcomes. However, the associations between maternal dyslipidemia and pregnancy complications in women with different diabetes mellitus types remain unclear. The aim of this study was to assess the lipid profile in women with different types of diabetes mellitus (Type 1, Type 2, and gestational diabetes) based on the therapy in the third trimester of pregnancy, to investigate the associations between serum lipid profile and perinatal complications, and to determine possible prognostic value of lipids in the development of adverse pregnancy outcomes.
 Study design, materials and methods: The study included 277 women who were divided into several groups depending on the type of diabetes mellitus and its therapy method, a group of patients with preeclampsia, and the control group. We analyzed the clinical and laboratory data of outpatient and inpatient cards of pregnant women in the period between 2010 and 2017. Maternal blood samples were collected between 28 and 32 weeks of gestation. The samples were assayed for fasting triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and very-low-density lipoprotein cholesterol concentrations, as well as the atherogenic index of plasma. We also assessed the incidence of gestational arterial hypertension, preeclampsia, intrauterine growth restriction, and preterm birth.
 Results: Pregnant women with various types of diabetes mellitus were characterized by a significant rise in serum triglycerides and very-low-density lipoprotein cholesterol levels, an increase in the atherogenic index of plasma, and a significant decrease in antiatherogenic, high-density lipoprotein cholesterol levels. These changes were most pronounced in pregnant women with pregestational diabetes mellitus types and in groups receiving insulin therapy. Correlation analysis revealed weak positive correlations between serum triglycerides concentrations and macrosomia (r = 0.26) and between the atherogenic index of plasma and severe preeclampsia (r = 0.26). The analysis of the ROC curve showed that triglycerides, very-low-density lipoprotein cholesterol, and the atherogenic index of plasma are predictors of severe preeclampsia.
 Conclusion: Diabetic pregnancies are associated with increased dyslipidemia, which plays an essential role in the pathogenesis of perinatal complications. Evaluating lipid profile markers in the third trimester of diabetic pregnancy may be valid predictors of severe preeclampsia.
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Samara, Diana, Magdalena Wartono, and Adrianus Kosasih. "The Correlation between Laboratory Metabolic Profile and Blood Pressure." Jurnal Biomedika dan Kesehatan 7, no. 1 (2024): 61–70. http://dx.doi.org/10.18051/jbiomedkes.2024.v7.61-70.
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Background High blood glucose and cholesterol are risk factors for hypertension. This study aims to determine the correlation between blood glucose and cholesterol levels with blood pressure in the normal blood pressure (NBP), controlled hypertension (CHT), and uncontrolled hypertension groups (UHT). Methods The study used a cross-sectional design with analytic observations on subjects aged 36 years or older. Ninety-five subjects were divided into three groups: NBP, CHT, and UHT. Subjects were men and women, without chronic heart failure or chronic renal failure. Samples were taken by consecutive random sampling. Blood pressure, body mass index, random BG, and lipid profile (triglycerides, HDL, LDL, total cholesterol) were measured. Statistical test using Spearman correlation test with p-value <0.05 significantly. Results There were 95 subjects with a range age of 36-81 years old. There were 30 NBP subjects, 34 CHT subjects, and 31 UHT subjects. There was a weak positive correlation between HDL level and diastolic BP in the NBP group (r=0.391;p=0.032). There was no correlation between blood glucose and other lipid profiles with BP in the three groups. Conclusions The increase in HDL is accompanied by an increase in diastolic blood pressure in NT but not with random blood sugar and other lipid profiles in all three blood pressure groups.
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Vrijkotte, Tanja G. M., Náthalie Krukziener, Barbara A. Hutten, Karlijn C. Vollebregt, Manon van Eijsden, and Marcel B. Twickler. "Maternal Lipid Profile During Early Pregnancy and Pregnancy Complications and Outcomes: The ABCD Study." Journal of Clinical Endocrinology & Metabolism 97, no. 11 (2012): 3917–25. http://dx.doi.org/10.1210/jc.2012-1295.
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Context: Elevated lipid levels during late pregnancy are associated with complications and adverse outcome for both mother and newborn. However, it is inconclusive whether a disturbed lipid profile during early pregnancy has similar negative associations. Objective: Our objective was to investigate whether nonfasting maternal total cholesterol and triglyceride levels during early pregnancy are associated with six major adverse pregnancy outcomes. Methods: Data were derived from the Amsterdam Born Children and Their Development (ABCD) cohort study. Random blood samples of nonfasting total cholesterol and triglyceride levels were determined during early gestation (median = 13, interquartile range = 12–14 wk). Outcome measures were pregnancy-induced hypertension (PIH), preeclampsia, preterm birth, small/large for gestational age (SGA/LGA), and child loss. Only nondiabetic women with singleton deliveries were included; the baseline sample consisted of 4008 women. Analysis for PIH and preeclampsia were performed in nulliparous women only (n = 2037). Results: Mean (sd) triglyceride and total cholesterol levels were 1.33 (0.55) and 4.98 (0.87) mmol/liter, respectively. The incidence of pregnancy complications and perinatal outcomes were as follows: PIH, 4.9%; preeclampsia, 3.7%; preterm birth, 5.3%; SGA, 9.3%; LGA, 9.3%; and child loss, 1.4%. After adjustments, every unit increase in triglycerides was linearly associated with an increased risk of PIH [odds ratio (OR) = 1.60, P = 0.021], preeclampsia (OR = 1.69, P = 0.018), LGA (OR = 1.48, P &lt; 0.001), and induced preterm delivery (OR = 1.69, P = 0.006). No associations were found for SGA or child loss. Total cholesterol was not associated with any of the outcome measures. Conclusions: Elevated maternal triglyceride levels measured during early pregnancy are associated with pregnancy complications and adverse pregnancy outcomes. These results suggest that future lifestyle programs in women of reproductive age with a focus on lowering triglyceride levels (i.e. diet, weight reduction, and physical activity) may help to prevent hypertensive complications during pregnancy and adverse birth outcomes.
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Amauche Martina Ngwu, Doris EyiucheEzigbo, and Modesta Chiamaka Njoku. "Differences by age and marital status in hypertensive patients in Enugu." GSC Biological and Pharmaceutical Sciences 31, no. 2 (2025): 106–12. https://doi.org/10.30574/gscbps.2025.31.2.0184.
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Hypertension is a well-established risk factor for cardiovascular disease and is known to increase with age across all populations. Lipid abnormalities often co-occur with hypertension, further compounding cardiovascular risk. This study assessed the influence of age and marital status on lipid profiles among hypertensive patients in Enugu, Nigeria. A total of 70 hypertensive patients aged 30–70 years receiving treatment at Enugu State University Teaching Hospital were enrolled. Demographic data, including age and marital status, were collected using a structured questionnaire. Blood pressure was measured, and fasting lipid profiles—including total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL)—were analyzed from serum samples using standard laboratory methods. Data were analyzed using Analysis of Variance (ANOVA) and Pearson correlation coefficients. The study population consisted of 54.3% married women (n=38), 30.0% married men (n=21), and 15.7% unmarried individuals (n=11). Married men had significantly lower HDL levels (0.857 ± 0.183 mmol/L) compared to married women (1.021 ± 0.243 mmol/L; p=0.015). Among married men, diastolic blood pressure showed a significant positive correlation with total cholesterol (r=0.468, p<0.05) and LDL cholesterol (r=0.438, p<0.05). The findings suggest that marital status, particularly among men, may influence lipid metabolism in hypertensive individuals. Married men exhibited lower HDL levels and a significant association between diastolic blood pressure and both total cholesterol and LDL, indicating a potentially heightened cardiovascular risk profile.
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Nahid, Sanzida, Nahid Parveen, and Shahnaj Begum. "Changes in Lipid Profile in Preeclampsia." Ibrahim Cardiac Medical Journal 12, no. 2 (2023): 53–58. http://dx.doi.org/10.3329/icmj.v12i2.69862.
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Background & objective: Preeclampsia is an age-old pregnancy-specific disorder. Numerous theories and ideas have been advanced on its etiology, pathophysiology, and complications, but commendable progress in preventing this long-standing disorder has not yet been made. The relationship between altered blood lipid levels and preeclampsia is currently a topic of discussion. The present study was to ascertain whether serum lipid levels are associated with preeclampsia. Methods: The present case-control study was carried out at the Department of Obstetrics & Gynaecology, Dhaka Medical College Hospital and Department of Obstetrics & Gynaecology, BSMMU, Dhaka over a period of one year between January 2011 to December 2011. Pregnant women in their 3rd trimester with preeclampsia were included as cases, while normal pregnant women at term without preeclampsia were included as controls. An equal number of cases (n = 75) and controls (n = 75) were selected consecutively. While the exposure variable was preeclampsia, the outcome variable was dyslipidaemia, which was defined as either total cholesterol:HDL ratio>4.5 or triglyceride:HDL ratio > 3.5. Result: The cases and the controls were almost identical in terms of age. The gestational age was also comparable between groups. The preeclamptic patients were predominantly primigravidae (57.3%) and overweight or obese (85.3%). Past history of PET was found in 12% cases as opposed to none in the controls. The prevalences of elevated serum total cholesterol (TC), LDL-C, and triglycerides (Tg) were considerably higher in the case group than those in the control group, although the differences were not statistically significant. However, the prevalence of low HDL-C was significantly higher in the former group than that in the latter group (56% vs. 14.7%, p < 0.001). The incidences of raised total cholesterol and HDL ratio > 4.5 and raised triglyceride and HDL ratio > 3.5 were observed to be significantly higher in the case group than those in the control group(p< 0.001 and p < 0.001 respectively). The likelihood of having raised TC:HDL ratio was estimated to be 10.1(95% CI = 4.2 - 23.9) times higher and that of raised TG:HDL ratio was 3.7(95% CI = 1.9 - 7.4) times higher in the case group than those in the control group. Conclusion: The total cholesterol:HDL ratio and triglyceride:HDL ratio increase significantly in preeclamptic women compared to that in normal pregnant women. However, the alteration is presumably caused by a significant lowering of HDL cholesterol, the total cholesterol and triglyceride do not experience any significant change. Ibrahim Card Med J 2022;12(2):53-58
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Thimmineni Haritha, Sanjaykumar Kaminwar, Anish Reddy P, Eshwaraiah Vanaparthy, and Sunil Chowdary M. "Clinical Study of Lipid Profile in Intracerebral Haemorrhage in Tertiary care Center." Indian Journal of Public Health Research & Development 15, no. 1 (2024): 435–40. https://doi.org/10.37506/aajqa435.
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Background: Stroke caused by Intracerebral haemorrhage (ICH) has high mortality rate. Among various risk factors for ICH, hypertension is the most important factor. Certain population studies have reported a paradox of inverse association between serum cholesterol and risk of ICH. Aims and objectives: The study aim was to evaluate the serum lipid profile total cholesterol (TC), triglycerides (TGL), high density cholesterol (HDL-C), very low density cholesterol (VLDL-C) and low density cholesterol (LDL-C) in intracerebral haemorrhage patients and look for correlation. Methods: 50 patients with ICH admitted in Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar who fulfilled the inclusion and exclusion criteria were selected. The study design was a hospital based observational clinical study. History, clinical examination and investigations (CT & MRI Brain and basic blood biochemistry with serum lipid profile) were collected and the data were analysed statistically. Results: Majority of the ICH patients in our study were >55 years and were males. The total serum cholesterol was < 200mg/dl in 72 % of our patients, with a mean of 168.09 ±43.74mg%. Serum triglyceride level was patients, with mean of 108.26±43.31mg%. HDL-C was < 40 mg/dl in 76% of patients and VLDL-C was < 30mg/dl in 72% patients. The various lipid fractions observed were found to be low in majority of our ICH patients (p value < 0.05), suggesting a negative association between the two. The results obtained were comparable to other similar studies. Conclusion: Majority of intracerebral haemorrhage patients in our study had lower levels of total cholesterol, triglyceride, HDL-C, LDL-C and VLDL-C. Whether the inverse association between serum lipid levels and ICH is a true causal association or only by chance due to other common confounding factors needs to be evaluated with large scale studies.
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Zhang, Wen, Yingchao Chen, Xian Zhang, et al. "Association of follicle-stimulating hormone with lipid profiles in older women: a cross-sectional SPECT-China study." BMJ Open 13, no. 7 (2023): e072796. http://dx.doi.org/10.1136/bmjopen-2023-072796.
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AimsFollicle-stimulating hormone (FSH) is associated with higher risks of metabolic syndrome and diabetes in menopausal women. We aimed to investigate whether FSH was associated with the lipid profile in women older than 55 years.DesignThe data were obtained from a cross-sectional study.ParticipantsOur data were from the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors (China, including Shanghai and Zhejiang, Jiangxi and Anhui provinces). A total of 1795 women older than 55 years were selected.MethodsMorning serum sex hormones and lipid profiles were measured. Linear and logistic regression analyses were used to analyse the data.ResultsLower FSH was associated with lower high-density lipoprotein cholesterol (HDL-C) and higher triglycerides (TG), total cholesterol (TC)/HDL-C ratio and low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio (all p for trend <0.05) after adjusting for age and other sex hormones. After further adjustment for body mass index, diabetes and hypertension, the associations of FSH with the lipid profile weakened, but the associations of FSH quartiles with HDL-C and the TC/HDL-C ratio were still significant (both p for trend <0.05). Compared with women in the highest FSH quartile, the odds of low HDL-C (HDL-C<1.04 mmol/L) in women in the lowest FSH quartile were 5.25 (95% CI 1.60 to 17.26) (p for trend <0.05) in the fully adjusted model, and the odds of TC≥6.22 mmol/L, TGs≥2.26 mmol/L and LDL-C≥4.14 mmol/L were not significant. Luteinising hormone did not show a significant association with dyslipidaemia.ConclusionLower FSH was associated with a worse lipid profile in women older than 55. Diabetes, adiposity and hypertension mostly explained the association of FSH with TGs and the LDL-C/HDL-C ratio but only partially explained the associations of FSH with HDL-C and the TC/HDL-C ratio.
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Nadera, Yasmeen, Amatul Rahman Jaweria Syeda, and Ali Imtiyaz. "Study of Lipid Profile in Primary Hypertension." International Journal of Pharmaceutical and Clinical Research 15, no. 12 (2023): 1135–38. https://doi.org/10.5281/zenodo.11199531.
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Hypertension is a major public health problem in India and studies have been documented a high prevalence rate of hypertension in developing countries [1]. Cardiovascular diseases account for a large proportion of all deaths and disability worldwide. The elevation of blood pressure is secondary to raised total peripheral resistance, which in turn is caused by narrowing of the lumen of the peripheral arterioles, which are the main resistance vessels. The aim of the present study is to compare and analyse the relation between blood pressure and lipid parameters in hypertensives and normotensives so that it will be a useful predictor of coronary artery disease. The study is undertaken in 50 hypertensives taken as subjects and 50 normotensives taken as controls with the age range being 40- 60 yrs. Ethical committee clearance was taken and consent obtained from all the study subjects. In the present study, it was found that the mean values of Total cholesterol and LDL cholesterol, are higher with more significance (p < 0.01) and VLDL cholesterol and Triglycerides are higher with less significance (p < 0.05) in hypertensives. The mean values of HDL Cholesterol are found to be lower with less significance (p < 0.05) in hypertensives. Thus, it can be concluded that in patients of primary hypertension, significant changes are seen in lipid profile which can be used for early detection of individuals prone to hypertension.
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Octavia, Zana Fitriana, Kis Djamiatun, and Nyoman Suci. "Pengaruh pemberian yogurt sinbiotik tepung pisang tanduk terhadap profil lipid tikus sindrom metabolik." Jurnal Gizi Klinik Indonesia 13, no. 4 (2017): 159. http://dx.doi.org/10.22146/ijcn.19369.
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Background: The metabolic syndrome, which is characterized by hyperglycemia, obesity, dyslipidemia, hypertension, prothrombic and proinflamatory state, is a risk factor for cardiovascular disease and diabetes mellitus. The synbiotic yogurt of tanduk banana (Musa paradisiaca fa. corniculata) flour contains lactic acid bacteria, fructooligosaccarides, flavonoids, and vitamin C which all of them play role in improving the lipid profile.Objective: The aim of this study was to prove the effect of synbiotic yogurt of tanduk banana flour on lipid profile of metabolic syndrome rats.Method: This study was an true experimental with pre-post test control group design. The subject of this study were 18 metabolic syndrome male Wistar rats divided into 3 groups,i.e control group (standart diet), intervention group I (standart diet and synbiotic yogurt of banana flour 0,009 ml/g weight/day), and intervention group II (standart diet and synbiotic yogurt of banana flour 0,018 ml/g weight/day). The intervention period was 2 weeks. Different test before and after intervention used paired t-test. The difference test between groups used One-Way ANOVA and Kruskal wallis.Results: The result showed that both of intervention group improved lipid profile significantly (p<0,05). The intervention group II showed more effective improvement of lipid profile significantly (p<0,05) than intervention group I. The intervention group II decreased triglycerides level 41,56%; total cholesterol level 41,39%; LDL-cholesterol level 57,5%; and increased HDL-cholesterol level 139,62%.Conclucion: The intervention of synbiotic yogurt of tanduk banana flour can decrease triglyceride level, total cholesterol level, LDL-cholesterol level, and increase HDL-cholesterol level.
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Gordon, Lorenzo, Dalip Ragoobirsingh, Errol Y. St A. Morrison, Eric Choo-Kang, Donovan McGrowder, and E. Martorell. "Lipid Profile of Type 2 Diabetic and Hypertensive Patients in the Jamaican Population." Journal of Laboratory Physicians 2, no. 01 (2010): 025–30. http://dx.doi.org/10.4103/0974-2727.66709.
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ABSTRACT Aims: Previous studies have shown that diabetes mellitus (DM) increases the risk of cardiovascular diseases in females to a greater extent than in males. In this cross-sectional study, we evaluated the lipid profiles of type 2 diabetic males and females. Materials and Methods: The study included 107 type 2 diabetic patients (41 males and 66 females), and 122 hypertensive type 2 diabetic patients (39 males and 83 females), aged 15 years and older. Total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C) and high density lipoprotein-cholesterol (HDL-C) concentrations were assayed for each group using standard biochemical methods. Results: The mean TC, TG, VLDL-C, HDL-C and LDL-C concentrations, TG/HDL and LDL/HDL ratios were higher in type 2 diabetic and hypertensive type 2 diabetic patients compared with non-diabetic, and hypertensive non-diabetic control subjects, although these were not significant (P > 0.05). Hypertensive type 2 diabetic females had significantly higher serum TC (7.42 ± 1.63 mmol/L) than hypertensive non-diabetic males (5.76±1.57 mmol/L; P < 0.05). All the other lipid and lipoprotein parameters except HDL-C were non-significantly higher in females with type 2 DM and those with hypertension and type 2 DM, compared with type 2 diabetic and hypertensive type 2 diabetic males, respectively (P > 0.05). Conclusion: This study demonstrated that dyslipidemia exists in our type 2 diabetic population with greater TC in hypertensive type 2 diabetic females compared with hypertensive type 2 diabetic males. This suggests that hypertensive type 2 diabetic females are exposed more profoundly to risk factors including atherogenic dyslipidemia compared with males.
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Dr, Aqsa Choudhary Dr Masooma Batool Dr Muntaha Munawar. "A DESCRIPTIVE RESEARCH TO ASSESS THE LIPID PROFILE AMONG PATIENTS DIAGNOSED WITH HYPERTENSION AT MAYO HOSPITAL, LAHORE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 04 (2019): 8548–55. https://doi.org/10.5281/zenodo.2652822.
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<strong><em>Objective: </em></strong><em>The purpose of this study was to see the lipid profile in hypertension cases.</em> <strong><em>Methods: </em></strong><em>This descriptive study held at Mayo Hospital, Lahore from April 2017 to August 2018. A total of 100 patients admitted with hypertension were the participants of the study. The patients are in the range of 40-80 years. Both known hypertensive patients who were on treatment for a varying time and newly diagnosed hypertensive patients participated in the study.</em> <strong><em>Results: </em></strong><em>Serum TC, LDL/ HDL, VLDL, TGL, TC/HDL, LDL, were much higher within the hypertensive group in comparison with healthy controls. HDL serum was deficient within patients of hypertension in comparison with controls, and the LDL was high within obese in comparison with non-obese patient value for both HDL and LDL was statistically significant. It was definitely found that LDL /HDL and TC/ HDL were high within obese patients, TC was high in the group of CVA, LDL was high in the IHD group, TC was high in the IHD group, LDL was high in the CVA group, and LDL/ HDL along with TC/ HDL was high in the CVA group in comparison with non-CVA group.</em> <strong><em>Conclusion: </em></strong><em>There was significant variation of lipid profile within hypertensive patients in comparison with controls. LDL cholesterol, triglycerides, total cholesterol, LDL/HDL, TC/HDL, and VLDL ratios were high within patients of hypertension. HDL was reduced in hypertensive patients. Hyperlipidemia was often observed in most cases of patients with Type IIa pattern. Mean TC /HDL, TC, LDL/ HDL, LDL were found high within obese. Average TC, TC/ HDL, LDL/ HDL, and LDL ratios are raised in a group of CVA. The average TC and LDL were high in the group of IHD. </em> <strong><em>Keywords</em></strong><em>: Hypertension; TC; LDL; HDL; VLDL; TGL; Cerebrovascular accident; Ischemic heart diseases; Obesity.</em>
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Sandhya, Kumari, Sinha Sushma, and Shukla Dwivedy Lata. "A Study of Comparison of Serum Lipid Profile of Women with Pregnancy Induced Hypertension and Normal Pregnancy." International Journal of Pharmaceutical and Clinical Research 15, no. 8 (2023): 445–47. https://doi.org/10.5281/zenodo.11482154.
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<strong>Background:</strong> One of the main causes of fetomaternal morbidity is pregnancy-induced hypertension. Studies have indicated that early-stage PIH patients have altered serum lipid metabolism, which may aid in predicting PIH. The study’s objective was to examine the levels of serum lipids in women with naturally occurring pregnancy and hypertension. <strong>Methods:</strong> From August 2021 to July 2022, the study was carried out at the Department of Obstetrics and Gynecology, ANNMCH, Gaya, Bihar. In each group, 40 women were chosen after exclusion and inclusion criteria were applied. A thorough history and clinical examination were followed by a routine investigation, lipid profile assessment, and data analysis. <strong>Results:</strong> Serum lipid level in the PIH group was significantly higher compared to normal group. Women with PIH had significantly higher values of total cholesterol (348mg/dl, SD±45), Triglycerides (368 mg/dl, SD ±39), LDL (201 mg/dl, SD±17)and VLDL (107 mg/dl, SD±11) as compared to normotensive pregnant women, total cholesterol (135mg/dl, SD±8.7), Triglycerides (120mg/dl, SD ±20), LDL(83 mg/dl, SD ±4.7)and VLDL(26mg/dl, SD±5) with p value of 0.0001. However HDL level is found to be significantly higher (p value<0.05) in normal group (61 mg/dl, SD 2.81) as compared to PIH group (34.3 mg/dl, SD ±4.3). <strong>Conclusion:</strong> In conclusion, compared to pregnant women with normotensive blood pressure, women with PIH have greater levels of total cholesterol, triglycerides, LDL, VLDL, and low HDL. Early identification of PIH may benefit from prenatal testing for serum lipid levels.
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Khobibah, Budi Astyandini, and Mimi Ruspita. "Aerobic Gymnastics Intervention on BMI, Abdominal Circumference and Lipid Profile in DMPA Acceptance." EMBRIO 13, no. 1 (2021): 1–9. http://dx.doi.org/10.36456/embrio.v13i1.3163.
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The risk of obesity and hypertension is associated with the influence of the hormone estrogen and the impact of the use of contraceptives. Use over one year is at risk of 1.36 times overweight, and will continue to increase in use over seven years (8.3 times). An important component for weight loss is aerobic exercise, so expected BMI, triglycerides, total cholesterol. LDL and HDL under normal conditions. Interventions in the form of treadmills, aerobic gymnastics or ergocycle. The purpose of this study is to determine the influence of aerobic gymnastics BMI, abdominal circumference and lipid profile of KB DMPA acceptors. The design was the quasi-experimental research (one group pretest posttest design). Pretest BMI, abdominal circumference, cholesterol, HDL and LDL were performed before and after the acceptor performed aerobic gymnastics a total of 16 meetings with a frequency of 3 times per week. The sample numbered 31 people. Data analysis using t-test and Wilcoxon. The results showed that aerobic gymnastics had no significant effect on BMI (p=0.818) and HDL (p=0.416) but had no significant effect on decreased abdominal fat (p=0.002), cholesterol (p = 0.044) and LDL (p=0.030). This recommendation of research is the need for routine physical activity such as aerobic gymnastics for DMPA KB acceptors so as to reduce complaints due to the side effects of DMPA contraceptives.
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Kala, Jaya Saklani, and Swapnil Singhai. "Management of Hyperlipidaemia through Ayurvedic Intervention." European Journal of Medical and Health Sciences 3, no. 3 (2021): 4–7. http://dx.doi.org/10.24018/ejmed.2021.3.3.815.
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The potential of hyperlipidemia to engage in the pathology of atherosclerotic diseases such as coronary heart disease, which dominates the scenario of diseases causing morbidity and mortality in the world. Hyperlipidemia is defined as elevated serum levels of cholesterol, triglycerides, or both. It is characterized by abnormally elevated lipid concentrations in blood caused by impaired lipid and lipoprotein metabolism and has the potential to cause a variety of complications such as cardiovascular disease, diabetes, obesity, hypertension, atherosclerosis, and so on. Hyperlipidemia is classified as Medoroga in Ayurveda. The results obtained for the lipid profile parameter demonstrated a significant change. The difference in total serum cholesterol is 36 mg/dl, serum triglycerides is 32 mg/dl, serum LDL is 40 mg/dl, serum VLDL is 15 mg/dl and serum HDL is -3 mg/dl.
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Dotsenko, O., and Z. Boiarska. "Age and gender characteristics of blood lipid profile in patients with hypertension and coronary heart disease." Visnyk of Lviv University. Biological series, no. 85 (February 25, 2021): 79–89. http://dx.doi.org/10.30970/vlubs.2021.85.09.
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Cardiovascular disease (CVD) in the 21st century remains the leading cause of death worldwide. In Ukraine, during 2020, 365,515 ukrainians died from heart disease and damage of the circulatory system. It is known that hypertension (AH) is one of the most important risk factors for atherosclerosis, accelerates its development and complicates the course, and these two diseases often accompany each other. Especially common is a combination of coronary heart disease (CHD), its various forms (angina, myocardial infarction, arrhythmia) and hypertension. The aim of the study was to establish the age and sex characteristics of the lipid profile of the blood of patients with hypertension and coronary heart disease. Analyzed the statistical data of a survey of 775 people (of which 436 women and 339 men). The data on total cholesterol, triglycerides and high-density lipoprotein cholesterol content for patients with hypertension and coronary disease was analyzed in order to assess the blood lipid spectrum. Statistical analysis and data processing was performed using standard methods of variation Statistics in the Statistics 8.0 software. Changes in lipid metabolism in patients with ischemic heart disease and hypertension were studied. The performed analysis of age-related and gender-related dynamics of blood lipid spectrum parameters – total triglycerides, total cholesterol (CS), low- and high-density lipoprotein cholesterol (LDL cholesterol and HDL cholesterol), the prognostic coefficient of atherogenicity (CA). It was found that the level of total cholesterol in women in the age groups <45 and 55–65 years old is higher than in similar groups in men. In age groups > 65 years, gender difference in total cholesterol levels is not observed. In age group 45–55 years, there are gender-dependent differences in the value of the prognostic coefficient of atherogenicity. For women there were no age-related changes in triglyceride levels. For men there is a dependence of the triglyceride’s levels with the age of patients. There were no significant differences in the levels of low- and high-density lipoproteins depending on gender.
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Forhad, CM Reza Qureshi, Asma Kabir, Tuhin Biswas, et al. "Status of Lipid Profile among the Hypertensive Patients in Bangladesh." University Heart Journal 10, no. 2 (2015): 73–77. http://dx.doi.org/10.3329/uhj.v10i2.26124.
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Back ground: Hypertension and dyslipidemia are associated with oxidative stress and are major causes of cardiovascular disease amounting to 30% of global death rate. It is widely accepted that cardiovascular disease is associated with hypertension and increased blood levels of low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides. In contrast, a low level of high density lipoprotein (HDL) is a risk factor for mortality from cardiovascular disease. Hypertension is a major public health problem in developed and developing countries. Methods: This study was a cross sectional study in which 159 diagnosed hypertensive patient and 75 with normal blood pressure (normotensive) were enrolled for compare. These patients sought a through health cheek up including blood pressure assessment between May 2012 to April 2013 in Tairunnessa Memorial Medical College and Hospital. Lipid parameters total cholesterol (TC), triglyceride (TG), low density lipoprotein ( LDLc) and high density lipoprotein (HDLc) were estimated by enzymatic colorimetric test. Results: The mean of Systolic blood pressure and Diastolic blood pressure of hypertensive were higher than normotensive (p<0.001). The serum levels of total cholesterol, triglyceride and LDL-C in hypertensive subject were higher than normotensive and statistically significant (p<0.001). Serum HDL-C was significantly lower (p<0.001) in hypertensive patients than in normotensive. Age, waist circumference (WC), body mass index (BMI) showed significant association with hypertensive patients (p<0.001) than in normotensive subjects.The logistic regression analysis indicates hypertensive were 1.2 times higher total cholesterol, 1.3 times higher triglyceride and 1.2 times higher LDL-C than normotensive and was statistically significant (p<0.001). HDL-C was 1.08 times lower in hypertensive than normotensive and statistically significant p<0.001). Conclusion: Analytical results of the study revealed that hypertensive patients have been found to have close association with dyslipidemia. Hypertension and dyslipidemia can be modified either by proper life style changes or medical management or by the combination of the both. This study suggests that hypertensive patients need measurement of blood pressure and lipid profile at regular interval to prevent heart diseases and stroke.University Heart Journal Vol. 10, No. 2, July 2014; 73-77
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Patidar, Nihar, Kshitij Kumar, B. B. Gupta, and R. K. Jha. "STUDY OF LIPID PROFILE OF PATIENT WITH ACUTE MYOCARDIAL INFARCTION." International Journal of Advanced Research 10, no. 12 (2022): 1374–80. http://dx.doi.org/10.21474/ijar01/15979.
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Background- There is discussion over the biomarker potential of using different lipid fractions to predict the risk of acute myocardial infarction (AMI). In order to compare the lipid profiles of 67 AMI patients, we looked at serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglycerides (TG). Material And Method- A prospective, cross-sectional study was conducted in the SAIMS emergency/opd. Within 24hours of onset of chest pain. All patients admitted with AMI were included after providing informed consent. Results- Among 200 AMI Patients included 100 STEMI (ST- elevated myocardial infarction) patients, 100 NSTEMI (non-ST-elevated myocardial infarction) patients. The median age of STEMI patient was 57.7years while that of NSTEMI patients 60.3 years. BMI of STEMI 24.6 kg/m2 and NSTEMI 24.9 kg/m2. History of diabetes was present in 22% STEMI patient while that of NSTEMI patients 39%. History of hypertension is present in 52 % STEMI patient and 68% of NSTEMI patients. 49 % STEMI patients were currently smoking while only 36% among NSTEMI patients. Conclusion- The lipid paradox exists for STEMI patients LDL-C and TC levels and hospitalisation, 30-day, and 1-year mortality. NSTEMI patients have a lipid pseudo-paradox. HDL-C, myocardial infarction type, and hospital death are interrelated. These results need more study.
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Alexescu, Teodora Gabriela, Ioana Roxana Bordea, Angela Cozma, et al. "Metabolic Profile and the Risk of Early Atherosclerosis in Patients with Obesity and Overweight." Revista de Chimie 70, no. 10 (2019): 3627–33. http://dx.doi.org/10.37358/rc.19.10.7610.
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Obesity and Overweight have the highest rate of incidence and prevalence in the past 3 decades, as global pathologies. The purpose of this study was to evaluate cardiovascular, classic and modern risk factors in overweight and obese patients by studying lipid metabolism (total cholesterol, HDL-cholesterol, non-HDL-cholesterol, LDL-cholesterol, serum triglycerides), glucose metabolism, insulin resistance and insulin sensitivity, the prevalence of hypertension (HBP) and the prevalence of metabolic syndrome (MS). This analytical study was performed on 111 subjects divided as follows: Group I consisting of 27 normal weight subjects - NW; Group II consisting of 84 overweight and obese subjects - OW + O: 36 overweight patients - OW; 33 patients with grade I obesity - O-I; 13 patients with grade II obesity - O-II; 2 patients with grade III obesity - O-III. The overweight and obese, although unknown with heart disease, have significant metabolic changes, such as atherogenic dyslipidemia, dysglycemia, high insulin resistance and low insulin sensitivity, metabolic syndrome, these being the first steps towards endothelial dysfunction and early atherosclerosis.
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Assiri, Khalil Ibrahim, Ali Mosfer A. Alqahtani, Abdullah Alqarni, et al. "Salivary Nitrate Level and Lipid Profile in Patients with Hypertension: A Cross-Sectional Study in a Saudi Sub-Population." Journal of Clinical Medicine 13, no. 23 (2024): 7051. http://dx.doi.org/10.3390/jcm13237051.
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Background: The use of salivary biomarkers offers a non-invasive approach to understanding the metabolic and inflammatory status of hypertensive patients. This study aimed to quantify the salivary nitric oxide (NO), total cholesterol, triglycerides, high-density lipoproteins (HDL), and low-density lipoproteins (LDL) levels in hypertensive individuals and healthy controls in a sub-population in Saudi Arabia. Methods: This cross-sectional study comprised 40 hypertensive patients (test group, 40–50 years old) and 40 age-matched healthy controls who visited the dental hospital in the College of Dentistry, King Khalid University, for dental treatment. Nitric oxide, total cholesterol, triglycerides, HDL, and LDL levels in saliva were assessed. An independent sample t-test was used to compare the results between the hypertensive and control groups. Results: The mean triglyceride and cholesterol levels in the test group were significantly higher (p < 0.05) than those in the control group. Alternatively, the NO level in the test group was significantly (p = 0.014) lower than that in the controls. The triglyceride level was significantly correlated with age in the test group (p = 0.04). Conclusions: This study demonstrated significant differences in the nitrate levels and lipid profiles between hypertensive patients and healthy individuals in a sub-population in Saudi Arabia. The findings indicate that saliva can be used as a non-invasive diagnostic tool for assessing nitrate levels and the lipid profile. However, additional studies with larger sample sizes and more precise testing parameters are required to validate the findings.
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Rezende, Gabriela Pravatta, Thamyse Dassie, Daniela Angerame Yela Gomes, and Cristina Laguna Benetti-Pinto. "Cardiovascular Risk Factors in Premature Ovarian Insufficiency using Hormonal Therapy." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 45, no. 06 (2023): 312–18. http://dx.doi.org/10.1055/s-0043-1770088.
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Abstract Objective Premature ovarian insufficiency (POI) is characterized by early hypoestrogenism. An increased risk of cardiovascular (CV) disease is a long-term consequence of POI. A challenge of hormone therapy (HT) is to reduce the CV risk. Methods Cross-sectional study with lipid profile analysis (total cholesterol, LDL-C, HDL-C, VLDL-C and triglycerides), blood glucose levels and arterial blood pressure of women with POI using HT, compared with age and BMI-matched women with normal ovarian function (controls). Results The mean age and BMI of 102 POI patients using HT and 102 controls were 37.2 ± 6.0 and 37.3 ± 5.9 years, respectively; 27.0 ± 5.2 and 27.1 ± 5.4 kg/m2. There wasn't difference between groups in arterial systolic and diastolic blood pressure, blood glucose levels, total cholesterol, LDL-C, VLDL-C and triglycerides. HDL-C levels were significantly higher in the POI group (56.3 ± 14.6 and 52 ± 13.9mg/dL; p = 0.03). Arterial hypertension was the most prevalent chronic disease (12% in the POI group, 19% in the control group, p = ns), followed by dyslipidemia (6 and 5%, in POI and control women). Conclusion Women with POI using HT have blood pressure levels, lipid and glycemic profile and prevalence of hypertension and dyslipidemia similar to women of the same age and BMI with preserved gonadal function, in addition to better HDL levels.