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Journal, Baghdad Science. "Evaluation the Levels of Serum Hormones (Progesterone, Estradiol, and hCG) in Preeclamptic IraqiPregnancies." Baghdad Science Journal 9, no. 2 (June 3, 2012): 244–50. http://dx.doi.org/10.21123/bsj.9.2.244-250.
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This study aimed to evaluate serum levels of steroid hormones and human chorionic gonadotropin (hCG) hormone in preeclamptic Iraqi pregnancies compared to those of healthy pregnancies.This study enrolled 120 pregnant women, divided into four groups:1. 30 healthy pregnant women.2. 37 pregnant women with mild preeclampsia3. 53 pregnant women with severe preeclampsia4. 90 pregnant women with preeclampsia Preeclamptic women and their severe cases but not mild cases had significantly (P
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Bereketoğlu, Ceyhun, Mülkiye Kasap, and Ayfer Pazarbaşı. "Studies on Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Genotype Distributions in Turkish Preeclampsia Patients." Journal of Pregnancy 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/108206.
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Placental, immune and genetic factors are thought to play an important role in preeclampia (PE)’s pathophysiology. Angiotensin-Converting Enzyme (ACE) plays a vital role in the renin-angiotensin-system (RAS) which regulates blood pressure by converting angiotensin I into a powerfull vasoconstrictor angiotensin II. A deletion polymorphism (D allele) has been reported to be associated with elevated ACE activity. The aim of the this study was to investigate whether there is an association between angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and PE. In this study, 120 preeclamptic and 116 normotensive Turkish pregnant women were genotyped for ACE I/D polymorphism and the distribution of genotype and allele frequencies of this polymorphism in preeclampsia and controls were evaluated. Codominant, dominant and recessive models were appplied in ACE gene I/D polymorphism. In the codominant model, DD genotype was found significantly more frequent in preeclampsia than controls (P=0.016). Moreover, in dominant model (DD frequency versus DI+II frequency) there was a significant relation between DD genotype and preeclampsia (P=0.006). D allele frequency was 64.6% in preeclampsia while it was 56.1% in controls (P=0.062). In conclusion, there was significant difference in genotype distribution between preeclampsia and controls.
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Alghazali, Basima, and Karim Tabarak. "Serum catestatin level in preeclampsia." Scripta Medica 55, no. 5 (2024): 547–55. http://dx.doi.org/10.5937/scriptamed55-49730.
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Background/Aim: Preeclampsia, a significant cause of maternal morbidity and mortality, is linked to increased cardiovascular risks. Catestatin regulates cardiovascular function which indicates its usefulness in understanding pathophysiology of preeclampsia and its severity. Aim of this study was to evaluate association of catestatin in preeclamptic women and control non preeclamptic women and assess its association with presence and severity of preeclampsia. Methods: A case-control study at Al-Zahraa Teaching Hospital, Iraq, performed from January to December 2023 involved 90 pregnant women: 30 with severe preeclampsia, 30 with mild preeclampsia and 30 healthy controls. Inclusion criteria were preeclamptic pregnant women at 27-40 weeks of gestation and age ranging from 20-40 years and similar non-eclamptic controls. Exclusions were smokers, chronic drug users and those with chronic illnesses. Data collection included general and clinical information, BMI, vital signs, examinations and laboratory tests including serum catestatin. Results: Catestatin levels varied significantly among severe preeclampsia, mild preeclampsia and control groups. Average catestatin level in severe preeclampsia group was markedly lower at 29.01 ng/mL, compared to 43.67 ng/mL in mild preeclampsia and 59.96 ng/mL in controls. The diagnostic performance of catestatin for severe preeclampsia was notable, with a cutoff point of ≤ 37.165 ng/mL, sensitivity of 80 % and specificity of 83.3 %, highlighting its potential as a critical biomarker in preeclampsia evaluation. Conclusion: Catestatin level was significantly lower in sever preeclampsia compared to mild and control group, which may indicate its association with preeclampsia. Lower catestatin in sever preeclampsia suggest its inverse relation with preeclampsia severity.
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Mira Kusuma Wardhani. "TNF-α, TNF-R1, TNF-R2 levels in women with normal pregnancy, preeclampsia, and preeclampsia with sepsis." World Journal of Advanced Research and Reviews 15, no. 3 (September 30, 2022): 358–56. http://dx.doi.org/10.30574/wjarr.2022.15.3.0948.
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Preeclampsia (PE) is a disorder in pregnancy with a worldwide prevalence of about 5-8% of cases. TNF is the main physiological mediator of the inflammatory process. These membrane-bound and soluble cytokines are biologically active. They have different affinities for two types of TNF receptors, apoptotic receptors (TNFR1) and non-apoptotic receptors (TNFR2). This study reveals the levels of TNF-α, TNF-R1, TNF-R2 in women with normal pregnancy, preeclampsia, and preeclampsia with sepsis. An observational analytic cross sectional research design is applied. The minimum number of sample is 14 women for each group (group 1: women with normal pregnancy, group 2: preeclampsia, and group 3: preeclampsia with sepsis). The results show that · There is an increase in TNF- levels in preeclamptic women and in preeclamptic women with sepsis · There is an increase in TNF-R1 receptor levels in preeclamptic women and in preeclamptic women with sepsis There is an increase in TNF-R2 receptor levels in preeclamptic women and in preeclamptic women with sepsis.
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Rahardjo, Bambang, Tatit Nurseta, and Aqua Rossalinda Sinaga. "Profile Tumor Necrosis Factor Alpha and Procalcitonin in Preeclampsia and Preeclampsia with Sepsis." Open Access Macedonian Journal of Medical Sciences 11, B (May 4, 2023): 299–304. http://dx.doi.org/10.3889/oamjms.2023.11644.
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BACKGROUND: Preeclampsia is hypertension in pregnancy which are characterized by high blood pressure, proteinuria that occur after 20 weeks of GA. Preeclampsia remains a massive cause of maternal morbidity and mortality that 50.000 death annually. The cause of preeclampsia is still unclear but there is a possibility caused by immunological processes in micro placenta environment during the early age of pregnancy. It is suggested that cytokines such as tumor necrosis factor (TNF-α) has an important role in the pathogenesis of preeclampsia. Preeclampsia is an extreme feature of the systemic inflammatory response during pregnancy. Systemic inflammation in preeclampsia can cause organ damage and induce sepsis. The pathophysiology is initiated by a high level of pro-inflammatory cytokine that released by peripheral blood mononuclear cell (PBMC). Beside pro-inflammatory cytokine, the marker of sepsis can be shown by procalcitonin (PCT) that produced by PBMC which is activated by TNF-α. AIM: The objective of the study is to evaluate profile maternal plasma levels of TNF-α and PCT and analyze their correlation in normotensive pregnant woman, preeclamptic and preeclampsia with sepsis. METHODS: An observational cross-sectional study. The sample were normotensive, preeclamptic, and preeclamptic with sepsis (n = 18) in Bangil Hospital, Pasuruan. The level of TNF-α and PCT was measured by ELISA. The statistical analysis with SPSS 18.0 with p < 0.05. RESULTS: This study showed level of TNF-α and PCT in preeclamptic with sepsis was significantly higher than control (p < 0.05) and not a significant difference in preeclampsia (p > 0.05). The level of TNF-α and PCT in preeclampsia compared with control was not a significant difference (p > 0.05). This study showed there was no correlation between TNF-α and PCT in patients with preeclampsia with sepsis. CONCLUSION: The plasma level of TNF-α and PCT was statistically different between the control group, preeclampsia and preeclampsia with sepsis. There was no significant difference of TNF-α and PCT plasma level in preeclampsia with sepsis than preeclampsia group. There was no significant correlation between preeclampsia in woman and preeclampsia with sepsis in maternal plasma TNF-α and PCT levels.
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Ekasari, Tutik, and Mega Silvian Natalia. "Pengaruh Pemeriksaan Kehamilan secara Teratur terhadap Kejadian Preeklamsi." JI-KES (Jurnal Ilmu Kesehatan) 3, no. 1 (November 4, 2019): 24–28. http://dx.doi.org/10.33006/ji-kes.v3i1.125.
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ABSTRAKKematian ibu tertinggi disebabkan oleh Preeklamsi. Kejadian preeklamsia dapat dikatakan sebagai masalah kesehatan masyarakat jika CaseFatalityRate (CFR) preeklamsia mencapai 1,4% - 1,8%.Menurut data terakhir prevalensi kejadian preeklamsia di Indonesia sekitar 3-10%. Angka tersebut menunjukkan bahwa kejadian preeklamsia di Indonesia melewati batas CFR sehingga preeklamsia menjadi salah satu masalah kesehatan masyarakat. Angka Kematian Ibu (AKI) pada tahun 2017 di Kabupaten Probolinggo sebanyak 14 orang. Penyebab langsung kematian ibu pada tahun 2017 disebabkan karena Perdarahan (15%), Preeklamsi/Eklamsi (50%), Infeksi (5%), Emboli Air Ketuban (5%), dan Lain-lain(25%). Semakin meningkatnya kejadian preeklampsi di Kabupaten Probolinggo diduga karena ibu hamil tidak memeriksakan kehamilannya secara teratur. Penelitian ini bertujuan menganalisis pengaruh pemeriksaan kehamilan secara teratur terhadap kejadian preeklamsia.Desain yang digunakananalitik korelasional dengan pendekatan Retrospektifstudy. Populasi yang digunakan semua ibu hamil pada tahun 2018. Teknik pengambilan sampel dengan purposive sampling dan diperoleh sampel sejumlah 200 orang yang memenuhi kriteria inklusi.Pengumpulan data menggunakan kuesioner dan wawancara. Uji statistik yang digunakan adalah Chi Square. Hasil penelitian menunjukkan bahwa terdapat 50% ibu hamil yang mengalami preeklamsi, sedangkan 59% dari ibu hamil yang mengalami preeklamsi tidak memeriksakan kehamilannya secara teratur. Setelah dianalisis dengan Chi Square didapatkan p value 0,003 yang artinya ada pengaruh pemeriksaan kehamilan secara teratur terhadap kejadian preeklamsi. Kata kunci : pemeriksaan kehamilan, teratur, preeklamsi ABSTRACTThe highest maternal mortality is caused Preeclampsia. The incidence of preeclampsia can be said to be a public health problem if the Case Fatality Rate (CFR) of preeclampsi areaches 1.4% - 1.8%. According to the latest data, the prevalence of preeclampsiain Indonesia is around 3-10%. This figures hows that the incidence of preeclampsiain Indonesia exceeds the CFR limit so that preeclampsia is one of the public health problems. The maternal mortality rate (AKI) in 2017 in Probolinggo Districtis 14 people. The direct cause of maternal deathin 2017 is caused by bleeding (15%), preeclampsia / eclampsia (50%), infection (5%), amnioticembolism (5%), and others (25%). The increasing incidence of preeclampsiain Probolinggo Regency is suspected because pregnant women do not check their pregnancy regularly. This study aims to analyze the effect of regular pregnancy examinations on the incidence of preeclampsia. The design used correlational analytic with a retrospective study approach. The population used was all pregnant women in 2018. The sampling technique was purposive sampling and a sample of 200 people met the inclusion criteria. Data collection used questionnaires and interviews. The statistical test used is Chi Square. The results showed that there were 50% of pregnant women who experienced preeclampsia, while 59% of pregnant women who experienced preeclampsia did not check their pregnancy regularly. After being analyzed with Chi Square, it was obtained p value 0.003, which means that the reisan effect of regula rpregnancy examinations on the incidence of preeclampsia. Keywords: pregnancy checkup, regular, preeclampsia
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Akhter, Selina, Taskina Ali, Shelina Begum, and Sultana Ferdousi. "Micronutrient Deficiency in Severe Preeclampsia." Journal of Bangladesh Society of Physiologist 8, no. 1 (October 25, 2013): 26–32. http://dx.doi.org/10.3329/jbsp.v8i1.16644.
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Background:. Micronutrient such as calcium, magnesium and zinc deficiency are associated with preeclampsia. Objective: To observe serum calcium, magnesium and zinc levels in severe preeclamptic women. Methods: This cross sectional study was carried out in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka from July 2009 to June 2010. 60 cases of preeclampsia, aged 18-39 years and >20th weeks of pregnancy were included in the study group. They were further sub divided into group B1 (30 mild preeclampsia) and group B2 (30 severe preeclampsia). Age and gestational period matched 30 normotensive pregnant women (Group A) were also studied as control. All the preeclamptic women were selected from the Obstetric and Gynaecology in and out patient Department of BSMMU and Dhaka Medical College Hospital. Serum calcium and magnesium was measured by colorimetric and serum zinc was measured by spectrophotometric method. For statistical analysis one way ANOVA, independent sample t test and ÷2 test were used. Results: The mean serum calcium, magnesium and zinc levels were significantly (p<0.001) lower in both group of preeclampsia than normotensive pregnant women. Again serum calcium and zinc levels were significantly lower (P<0.05) in severe preeclampsia compared to mild preeclampsia whereas serum magnesium levels were found almost similar in both group of preeclampsia (P>0.05). Again in this study, 40% mild, 73.3 % severe preeclamptic women and 20% normotensive pregnant women had hypocalcaemia. 36.7% mild, 30.0% severe preeclamptic women and 3.3% normotensive pregnant women had hypomagnesaemia and 6.7% mild, 20 % severe preeclamptic women and no normotensive pregnant women had hypozincemia. Conclusion: This study may conclude that micronutrient deficiency may be one of the risk factor of preeclampsia and increases the risk of its severity. Therefore early detection and supplementation to treat this deficiency may reduce the incidence of preeclampsia. DOI: http://dx.doi.org/10.3329/jbsp.v8i1.16644 J Bangladesh Soc Physiol. 2013, June; 8(1): 26-32
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Laskowska, Marzena. "Altered Maternal Serum Matrix Metalloproteinases MMP-2, MMP-3, MMP-9, and MMP-13 in Severe Early- and Late-Onset Preeclampsia." BioMed Research International 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/6432426.
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Objective. The aim of this study was to determine whether maternal serum matrix metalloproteinases 2, 3, 9, and 13 levels differ in early- and late-onset preeclampsia and uncomplicated pregnancies. Patients and Methods. The study was carried out in 125 pregnant women (29 with early-onset preeclampsia; 31 preeclamptic patients with late-onset preeclampsia; and 65 healthy pregnant controls). Levels of MMP-2, MMP-3, MMP-9, and MMP-13 were measured in the maternal serum using an enzyme-linked immunosorbent assay. Results. Maternal serum MMP-2 levels in both the groups of preeclamptic women were significantly higher than those in the controls. Levels of MMP-3 were significantly higher in preeclamptic patients with early-onset disease; however, the MMP-3 levels in patients with late-onset preeclampsia were similar to those observed in the control subjects. MMP-9 levels were lower whereas the levels of MMP-13 were higher in both preeclamptic groups of pregnant women than in the healthy controls, but these differences were statistically insignificant. Conclusions. One important finding of the present study was that MMP-3 appears to be involved solely in early-onset preeclampsia, but not in late-onset preeclampsia. Higher levels of MMP-2 and MMP-13 and lower levels of MMP-9 seem to be related to both early- and late-onset severe preeclampsia.
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Dewantiningrum, Julian, and Zaki Hetami. "Level of hsCRP Maternal Serum During Puerperium of Severe Preeclampsia." Journal of Biomedicine and Translational Research 4, no. 1 (July 30, 2018): 9. http://dx.doi.org/10.14710/jbtr.v4i1.2501.
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Background: Preeclampsia and eclampsia arestill major problemsin the world. Maternal mortality of severe preeclampsia at the puerperal period is likely to be greater because of the cardiovascular diseases (CVD). HsCRP (high sensitivity C-Reactive Protein) is a usefull prediction for CVD among non preeclamptic patients. Before using hsCRP as a marker for that prediction of cardiovascular event from preeclamptic patient, we should do research to know difference of hsCRP between preeclampsia and normal pregnancy.Objective: To determine the differences levels of hsCRP among severe preeclampsia and normal pregnancyMethod : A cross sectional study was conducted to severe preeclampsia. The inclusion criteria were subjects in puerperal period (2- 6 weeks) with a history of severe preeclampsia and normotensive.Exclusion criteria were puerperal infection, chronic hypertension, metabolic syndrome, caesarean section delivery and refuse to join this research. All subjects were examined the levels of hsCRP maternal serum when blood pressure £140 / 90.Result: Subjects were consist of 26 severe preeclampsia (53%) and 23 normal pregnancy (46.9%). Level of hsCRP in severe preeclampsia was 4.73 +3.57while in normotensive 2.42 +4.14 (p <0.05). Severe preeclampsia group will increase the risk of hsCRP rise as much as 2.5 times compared to the normotensive group.Conclusion:Level of hsCRP in patients with preeclampsia post partum were higher than patients with normal pregnancies.
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Parrales-Bravo, Franklin, Rosangela Caicedo-Quiroz, Leonel Vasquez-Cevallos, Elena Tolozano-Benites, Jorge Charco-Aguirre, Julio Barzola-Monteses, and Lorenzo Cevallos-Torres. "Supporting the Characterization of Preeclampsia Patients Through Descriptive and Clustering Analysis." Electronics 13, no. 23 (December 9, 2024): 4854. https://doi.org/10.3390/electronics13234854.
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One of the most common causes of maternal death during pregnancy is preeclampsia. A deeper understanding of the patient’s features can aid in the hospital’s clinical care distribution. However, at the IESS Los Ceibos Hospital, these types of studies have not been carried out for preeclampsia. Therefore, in this work, we describe the application of descriptive and clustering analysis to characterize preeclamptic patients. Preeclamptic patients treated at the IESS Los Ceibos Hospital in Guayaquil comprised the dataset used in this study. Descriptive and clustering analysis allowed us to find that severe preeclampsia (O141) is the most common diagnosis when preeclamptic patients arrive at the hospitalization unit, representing 79.5% of the cases. Moreover, women whose maternal age falls between 26 and 35 years have the highest prevalence of preeclampsia, representing 55.4% of the cases. Finally, adult patients in their late 30s or older are often diagnosed with severe preeclampsia (O141) and often require many hours of hospital care during the first two visits. These findings will help to generate care and prevention policies, such as the use of a low dose of aspirin, in these age groups to avoid the complications that preeclampsia can cause.
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Timalsina, S., and P. Gyawali. "Can serum prolactin be a reliable marker for preeclampsia? A hospital based study on Nepalese mothers." Journal of Chitwan Medical College 5, no. 1 (March 31, 2015): 2–5. http://dx.doi.org/10.3126/jcmc.v5i1.12558.
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Preeclampsia is a pregnancy specific complication characterized by hypertension, proteinuria and oedema. It has remained as a major cause of maternal and perinatal morbidity and mortality worldwide. The major function of prolactin is its role in lactation during pregnancy, but many authors have claimed that this hormone is also involved in angiogenesis, thus linking it with the pathogenesis of preeclampsia. In this context, our study aims to compare the serum prolactin level between preeclamptic and healthy pregnancies and correlate with the severity.A total of 54 pregnant women diagnosed with preeclampsia and 60 age and gestational weeks matched healthy pregnant women were recruited in this case control study. Preeclampsia was defined as per Australasian Society Consensus Statement research definition. Among 54 preeclamptic women, 41 had mild preeclampsia and 13 had severe preeclampsia. The mean age and the gestational weeks of the preeclamptic cases and pregnant controls were not significantly different. This study showed that the median concentration of prolactin was significantly higher in preeclampsia than in normal pregnancies (156.6 vs. 129.8 ng/mL, P=0.012). Though the median concentration of prolactin was higher in severe preeclampsia in comparison to mild one, the difference did not reach the significant level (228.3 vs.152.9 ng/mL, P=0.061). No significant correlation of prolactin was found with mean arterial pressure and 24h UTP. Due to poor correlation with established markers of severity, serum prolactin is not a reliable marker of preeclampsia.DOI: http://dx.doi.org/10.3126/jcmc.v5i1.12558
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Fato, Bianca R., Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Stephen Tong, Tu’uhevaha J. Kaitu’u-Lino, and Natalie J. Hannan. "Serum Collected from Preeclamptic Pregnancies Drives Vasoconstriction of Human Omental Arteries—A Novel Ex Vivo Model of Preeclampsia for Therapeutic Development." International Journal of Molecular Sciences 23, no. 18 (September 16, 2022): 10852. http://dx.doi.org/10.3390/ijms231810852.
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New-onset maternal hypertension is a hallmark of preeclampsia, driven by widespread endothelial dysfunction and systemic vasoconstriction. Here, we set out to create a new ex vivo model using preeclamptic serum to cause injury to the endothelium, mimicking vascular dysfunction in preeclampsia and offering the potential to evaluate candidate therapeutic interventions. Human omental arteries were collected at caesarean section from normotensive pregnant patients at term (n = 9). Serum was collected from pregnancies complicated by preterm preeclampsia (birth < 34 weeks’ gestation, n = 16), term preeclampsia (birth > 37 weeks’ gestation, n = 5), and healthy gestation-matched controls (preterm n = 16, term n = 12). Using wire myography, we performed ex vivo whole vessel assessment where human omental arteries were treated with increasing doses of each serum treatment (2–20%) and vasoreactivity was assessed. All pregnant serum treatments successfully drove vasoconstriction; no significant difference was observed in the degree of vasoconstriction when exposed to preeclamptic or control serum. We further demonstrated the ability of esomeprazole (a candidate therapeutic for preeclampsia; 0.1–100 µM) to drive vasorelaxation of pre-constricted vessels (only with serum from preeclamptic patients). In summary, we describe a novel human physiological model of preeclamptic vascular constriction. We demonstrate its exciting potential to screen drugs for their therapeutic potential as treatment for vasoconstriction induced by preeclampsia.
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Asadi-Tarani, Mina, Mohsen Saravani, Marzieh Ghasemi, Mahnaz Rezaei, and Saeedeh Salimi. "Maternal and placental ANRIL polymorphisms and preeclampsia susceptibility." Personalized Medicine 20, no. 5 (September 2023): 445–52. http://dx.doi.org/10.2217/pme-2023-0073.
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Aim: The possible effects of maternal and placental ANRIL polymorphisms on preeclampsia were examined. Methods: The maternal blood of 315 preeclamptic and 317 control women and the placentas of 103 preeclamptic and 133 control women were enrolled in the study. ANRIL polymorphisms were genotyped using a PCR–RFLP method. Results: The maternal ANRIL rs1333048C variant showed a relationship with a lower risk of preeclampsia in codominant and dominant models. The maternal ANRIL rs4977574G variant had a relationship with a lower risk of preeclampsia in codominant and recessive models. There was an association between the placental rs1333048C variant and a lower risk of preeclampsia in codominant and dominant models. Conclusion: Maternal ANRIL rs1333048C and rs4977574G variants and placental rs1333048 variant showed a relationship with a lower risk of preeclampsia.
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DO., Allagoa, Agbo OJ., and Orluwene CG. "Comparative Evaluation of Serum Calcium and Magnesium Level in Preeclamptic and NonPreeclamptic Women in a Tertiary Hospital in Southern Nigeria." European Scientific Journal, ESJ 14, no. 12 (April 30, 2018): 437. http://dx.doi.org/10.19044/esj.2018.v14n12p437.
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Background: Calcium and magnesium are two micronutrients whose role in the development of preeclampsia has been investigated over the years. There is paucity of studies on the role of serum levels of calcium and magnesium in the development of preeclampsia in south-south Nigeria. Objective: Our study evaluated the serum level of calcium and magnesium in preeclamptic and non preeclamptic women in a Tertiary Hospital in southsouth Nigeria. Methodology: We carried out a comparative study in which 52 preeclamptic and 52 non preeclamptic women, who satisfied the eligibility criteria, were enrolled for the study. Data entry and statistical analysis was done using statistical software (IBM SPSS® for windows version 21.0). Data were analyzed for mean and standard deviation. Comparison of serum levels of elements between the two groups was performed by student t-test, and P value < 0.05 was considered as statistically significant. Results: The serum calcium level was statistically lower in the women who developed preeclampsia compared to those who did not (8.37±0.91 mg/dl vs 9.33±1.15mg/dl, p<0.001). The serum magnesium level was not statistically different between women who had preeclampsia and those who did not (1.79±0.24mg/dl vs 1.88±0.37mg/dl, p = 0.102). The systolic and diastolic blood pressure showed a significant negative correlation with serum calcium level, unlike serum magnesiun level in those that had preeclampsia. Conclusion: This study showed that women who developed preeclampsia demonstrated reduced serum calcium level and no reduction in serum magnesium level. This study support the hypothesis that hypocalcaemia, unlike hypomagnecaemia, is a possible aetiology of preeclampsia.
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Akter, Halima, M. Tofazzel Hossain, and Shirin Shabnam. "The role of maternal serum homocysteine level in early onset preeclampsia for prediction of severity of disease." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 13, no. 10 (September 26, 2024): 2641–48. http://dx.doi.org/10.18203/2320-1770.ijrcog20242790.
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Background: This study was conducted to observe the relationship between high serum homocysteine levels and preeclampsia with severe features among preeclamptic pregnant women of 20-34 weeks of gestation. Method: This study was a hospital based a prospective cohort study and was conducted in Department of Obstetrics and Gynaecology in Dhaka Medical College. A total of 110 preeclamptic pregnant women of 20-34 weeks of gestational age were taken and data were collected after taking an informed written consent. After diagnosis of preeclampsia, I gave them some investigations like CBC, SGPT, S. Creatinine and S. Homocysteine. The patients were divided into two groups that is normal homocysteine level (Group-I) and elevated/high homocysteine level (Group-II) and then the patients were followed up by me at 2 to 4 weekly interval or more frequent if needed. Result: Among 110 preeclamptic women, mean age of the them was 27.2±6.84 (SD) years and gestational age was 28.0±2.58 (SD) weeks when patients developed preeclampsia without severe features. Majority were nullipara (51.8%) and overweight (54.5%). The mean BMI of the preeclamptic women were 28.2±3.46 kg/m2. The median (IQR) Homocysteine level was 11.4 (6.7-16.8) μmol/l and Hyperhomocysteinemia was reported in 31.8% of pregnant women. A cut-off value of homocysteine level≥15.3 μmol/l showed sensitivity, specificity, NPV, PPV and accuracy 91.3%, 83.9%, 60%, 97.3% and 85.4%, respectively to correctly predict preeclampsia with severe features. Homocysteine level was significantly associated with preeclampsia with severe features (p<0.05) and was higher in severe preeclamptic women (91.3%). The homocysteine level was higher in patients with severe features, median-18.3 (17.6-19.4) than without severe features median 9.14 (6.68-13.5). Women with Hyperhomocysteinemia had also greater fetal complications, FGR 20%, oligohydramnios 22.9%). The relative risk ratio of development of preeclampsia with severe features was 22.5, among the preeclamptic women having S. homocysteine level ≥15.3 µmol/l. Conclusion: The study shows that increased maternal serum homocysteine level at 20-34 weeks gestation in preeclampsia without severe features pregnant lady is a predictor of subsequent development of preeclampsia with severe features.
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Ezeigwe, Chijioke Ogomegbulam, Charles Ikechukwu Okafor, George Uchenna Eleje, Gerald Okanandu Udigwe, and Daniel Chukwuemeka Anyiam. "Placental Peripartum Pathologies in Women with Preeclampsia and Eclampsia." Obstetrics and Gynecology International 2018 (September 20, 2018): 1–8. http://dx.doi.org/10.1155/2018/9462938.
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Objective. To determine the pattern of pathological changes in placentas of preeclamptic/eclamptic parturients and its correlation with the clinical severity as well as the perinatal outcome.Methods. A cross-sectional analytical study of placental pathologies in preeclamptic/eclamptic patients was performed in a blinded pattern and compared with matched normal controls. Data were analyzed using Epi-Info 2008 version 3.5.1.Results. Placental pathologies were evaluated in 61 preeclamptic/eclamptic patients and in 122 controls. Of the 61 placentas, 53 (4.7%) were of preeclampsia while 8 (0.71%) were of eclampsia. Of the preeclamptic group, 14 (23%) had mild preeclampsia while 39 (63.9%) had severe preeclampsia. Infarction, haematoma, and some histological changes increased with the severity of preeclampsia (p<0.001). When comparing placentas in eclampsia, severe preeclampsia, mild preeclampsia, and normal controls, there was respective increase in the presence of any infarction (75%, 66.7%, 35.7% vs. 12.3%) or any haematoma (100%, 100%, 71.4% vs. 35.2%), decidual arteriopathy (87.5%, 76.9%, 64.3% vs. 35.2%), cytotrophoblastic proliferation (75%, 71.8%, 42.9% vs. 25.4%), and accelerated villous maturation (75%, 69.2%, 57.1% vs. 31.1%). There was no statistically significant difference in placental calcifications, stromal oedema, stromal fibrosis, and syncytial knots. Degree of placental infarction was correlated with the fetal birth weight. The fetal birth weight with placental involvement of >10% was significant (p=0.01).Conclusion. In mild or severe preeclampsia/eclampsia, placentas had significant histological signs of ischaemia and degree of placental involvement by infarction is inversely proportional to fetal birth weight. While feto-placental ratio was higher with increased severity of the disease, the mean weight was less. This trial is registered withresearchregistry3503.
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Khalida, Siti Nur, Erry Gumilar Dachlan, and Gatot Soegiarto. "Maternal distress during pregnancy related to preeclampsia." Bali Medical Journal 12, no. 3 (August 22, 2023): 2451–55. http://dx.doi.org/10.15562/bmj.v12i3.4715.
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Introduction: Maternal distress related to the occurrence of preeclampsia. The distress condition may disrupt the neuroendocrine and immune systems, activating the maternal HPA axis and increasing serum cortisol levels. The latter may affect the placental cortisol lvel, may alter the trophoblast invasion, which is the main pathology of preeclampsia. This study aims to assess the correlation between maternal distress and the incidence of preeclampsia using PSS and DASS-21 questionnaires. Methods: We conducted a cross-sectional study at two secondary hospitals in Surabaya, East Java, Indonesia from December 2022 until February 2023. Twenty women with preeclampsia and seventeen non-preeclamptic women as control were included in this study. Maternal distress was measured using self-reported PSS and DASS-21 questionnaires. Results: Preeclamptic women were significantly more depressed and stressed than the control group, while there was no significant difference in anxiety scores between groups. Maternal distress measured by PSS score positively correlated with the occurrence of preeclampsia (p<0,05; β-value 0,742). Conclusion: Maternal distress conditions were correlated with the occurrence of preeclampsia. Further research still needs to be done to unravel the mechanisms by which maternal distress can induce preeclampsia.
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Lafuente-Ganuza, Paula, Fran Carretero, Paloma Lequerica-Fernández, Ana Fernandez-Bernardo, Ana I. Escudero, Jesus M. de la Hera-Galarza, Daniel Garcia-Iglesias, Rut Alvarez-Velasco, and Francisco V. Alvarez. "NT-proBNP levels in preeclampsia, intrauterine growth restriction as well as in the prediction on an imminent delivery." Clinical Chemistry and Laboratory Medicine (CCLM) 59, no. 6 (February 15, 2021): 1077–85. http://dx.doi.org/10.1515/cclm-2020-1450.
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Abstract Objectives Studies of cardiovascular function in pregnancy have shown inconsistent and, in some cases, contradictory results, particularly regarding cardiac output. While some studies report preeclampsia associated with high cardiac output, other studies suggest that preeclampsia should be further subdivided into women with high or low cardiac output. This study was conducted to examine the NT-proBNP levels in preeclampsia, intrauterine growth restriction, and hypertensive pregnancies without preeclampsia. We also examined N-terminal pro-B natriuretic peptide (NT-proBNP) levels three to four months after delivery, in preeclamptic women as well as the prediction of delivery within 10 days. In a reduced number of preeclamptic women and controls we performed echocardiograms to study their diastolic function. Methods We investigated the NT-proBNP levels in 213 subjects with preeclampsia only, 73 with intrauterine growth restriction, 44 with preeclampsia and intrauterine growth restriction, 211 who were hypertensive and 662 unaffected pregnancies (controls). We also performed echocardiograms on 36 preeclampsia and 19 controls before delivery and three to five months after delivery. Results NT-proBNP levels are higher in early onset preeclampsia than in late onset preeclampsia. Intrauterine growth restriction pregnancies showed a NT-proBNP levels similar to hypertensive and unaffected pregnancies. Compared with healthy pregnancies, women with preterm preeclampsia (<37 gestational weeks) had altered left atrial segments. Conclusions We observed that NT-proBNP levels are higher in early onset preeclampsia than in late onset. Moreover, diastolic dysfunction is higher in early onset than in late-onset term preeclampsia. An NT-proBNP value >136 pg/mL has a high positive predictive value for an imminent delivery within 10 days.
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Ejaz, Saima, Reem Yaqoob, Reem Alkahtani, Anila Anila Khalique, Maryam Azam, Nousheen Mahmood, and Nada Saleh. "Association Of Socioeconomic Status With Preeclampsia In Pakistani Females." BioSight 2, no. 2 (December 31, 2021): 50–57. http://dx.doi.org/10.46568/bios.v2i2.54.
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Introduction: To identify whether there is an association between maternal socioeconomic status as in living style, and preeclampsia in women from Pakistan, and if so, to what extent it increases the risk of developing preeclampsia. Methods: This is a case-control study, consisting of 74 normal pregnant and 76 already diagnosed preeclamptic Pakistani females, recruited from various hospitals in Karachi. Their socioeconomic status was assessed through the standard of living index (SLI) using the National Family Health Surveys (NFHS) criteria, which considers different living facilities as an indicator of socioeconomic status. Odds ratios of preeclampsia were calculated for low, middle and high socioeconomic status and other maternal anthropometric parameters. Results: Based on their groups, it appeared that the highest percentage of preeclamptic females (n= 65; 43.3%) and the lowest of control patients (n=14; 9.3%) lie in lower socioeconomic groups and the results were highly significantly different. Study observed that having lower socioeconomic status (P<0.001) significantly increase risk of having preeclampsia by 9% and middle socioeconomic status has no role in prevalence of preeclampsia shown by 0.0 odds ratio. In addition, odds ratio of age and PreBMI for the preeclamptic females were found as 1.37 (P<0.001) and 1.55 (P<0.001) respectively, which shows that each year increase in age, increases risk of preeclampsia by 1.37 times and 1.55 times with each increased in BMI. Conclusion: Living facilities are indications of socioeconomic status and are strong risk factors of preeclampsia
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Yanglem, Ajitkumar S., Niren S. Koch, Sangeeta Naorem, Roshita D. Kshetrimayum, Guiphiuliu Kamei, Bidya Nongmaithem, and Reshmi Okram. "Serum malondialdehyde and serum glutathione peroxidase levels in pregnant women with and without preeclampsia." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 12, no. 11 (October 27, 2023): 3294–98. http://dx.doi.org/10.18203/2320-1770.ijrcog20233297.
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Background: Preeclampsia is a pregnancy-specific disorder that affects 10% of all pregnancies which contributes heavily to maternal mortality and perinatal morbidity. Several studies have shown that oxidative stress plays an important role in the pathogenesis of preeclampsia. However, the association has not been proven indisputably. So, the study was done with the view to determine serum malondialdehyde and glutathione peroxidase levels in pregnant women with and without preeclampsia and to compare the levels between the two groups of participants. Methods: This is a cross-sectional study conducted in the Department of Biochemistry and Department of Obstetrics and Gynaecology, RIMS. 55 preeclamptic patients and 55 pregnant women without preeclampsia were recruited as cases and controls respectively. Results: Serum malondialdehyde was found to be significantly higher in cases (1280.02±619.55ng/ml) than the controls (826.51±599.84ng/ml) and glutathione peroxidase levels were found to be significantly decreased in the preeclamptic women (224.49±201.29pg/ml) when compared to the normal healthy pregnant women (448±350.54 pg/ml. Serum malondialdehyde levels were found to be positively correlated with blood pressure. Conclusions: Serum malondialdehyde was increased in preeclampsia and serum glutathione levels was decreased in preeclamptic pregnant women when compared to the pregnant women without preeclampsia. Serum malondialdehyde levels were significantly correlated with high blood pressure. The oxidant-antioxidant system may be involved in the etiology of preeclampsia, however the cause and effect relation needs further evaluation.
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Psilopatis, Iason, Kleio Vrettou, Florian Nima Fleckenstein, and Stamatios Theocharis. "The Role of Peroxisome Proliferator-Activated Receptors in Preeclampsia." Cells 12, no. 4 (February 17, 2023): 647. http://dx.doi.org/10.3390/cells12040647.
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Preeclampsia is a common pregnancy-related hypertensive disorder. Often presenting as preexisting or new-onset hypertension complicated by proteinuria and/or end-organ dysfunction, preeclampsia significantly correlates with maternal and perinatal morbidity and mortality. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins that regulate gene expression. In order to investigate the role of PPARs in the pathophysiology of preeclampsia, we conducted a literature review using the MEDLINE and LIVIVO databases. The search terms “peroxisome proliferator-activated receptor”, “PPAR”, and “preeclampsia” were employed and we were able to identify 35 relevant studies published between 2002 and 2022. Different study groups reached contradictory conclusions in terms of PPAR expression in preeclamptic placentae. Interestingly, PPARγ agonists alone, or in combination with well-established pharmaceutical agents, were determined to represent novel, potent anti-preeclamptic treatment alternatives. In conclusion, PPARs seem to play a significant role in preeclampsia.
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Kaplan, Şehmus, Mehmet Uğur Karabat, Esranur Atiç, Muhyiddin Sancar, İlkan Alkan, and Fırat Aşır. "Histopathological Alterations in Placentas of Severe and Non-Severe Preeclamptic Patients." Journal of Drug Delivery and Therapeutics 14, no. 11 (November 15, 2024): 54–57. http://dx.doi.org/10.22270/jddt.v14i11.6886.
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Preeclampsia is a significant pregnancy complication associated with vascular lesions and trophoblastic invasion, leading to substantial maternal and fetal risks. This study compares histopathological changes in placental structures among severe and non-severe preeclamptic patients. Placental tissues were analyzed, revealing that preeclampsia groups showed notable villous degeneration, increased fibrin deposition, vascular dilatation, congestion, and syncytial node formation. Severe preeclampsia further exhibited intensified hemorrhage and leukocyte infiltration. These findings underscore the link between preeclampsia severity and placental dysfunction, providing insights into the pathological mechanisms affecting perinatal outcomes. Keywords: placenta, preeclampsia, HELLP, histology
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Al-Rubayi, Maisoon Hanoon, Faris Anwar Rasheed, and Alyaa Aziz Ahmed. "Serum β-hCG Levels in Pregnant Women with Mild and Severe Preeclampsia During the Third Trimester." Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ) 5, no. 1S (December 24, 2023): S195–200. http://dx.doi.org/10.54133/ajms.v5i1s.398.
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Background: Preeclampsia is a prevalent complication that frequently arises during pregnancy. It is a disorder of the trophoblasts. Given that human chorionic gonadotropin is secreted by the trophoblast, this complication may have an impact on its serum concentration. Objective: To compare the β-hCG levels of expectant women who are preeclamptic and those who are normotensive. Methods: A prospective cross-sectional study design was implemented at Al-Elweyia Maternity Teaching Hospital for this investigation. One hundred fifty expectant women in their third trimester are participating. The study participants were allocated into three cohorts, each consisting of 50 women: normotensive, mild preeclamptic, and severe preeclamptic. β-hCG levels in maternal serum were determined using an enzyme-linked immunosorbent assay (ELISA) in every instance. Results: Compared to expectant women with normotensive conditions and patients with mild preeclampsia, the levels of maternal serum β-hCG were significantly elevated in patients with severe preeclampsia. β-hCG levels were not significantly affected by maternal age across all three groups. Conclusion: β-hCG concentrations are greater in pregnant women with moderate and severe preeclampsia compared to normotensive women, with severe preeclampsia being more pronounced than mild.
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Liong, Stella, Gillian Barker, and Martha Lappas. "Bromodomain protein BRD4 is increased in human placentas from women with early-onset preeclampsia." Reproduction 155, no. 6 (June 2018): 573–82. http://dx.doi.org/10.1530/rep-17-0744.
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Preeclampsia affects 5% of all pregnancies and is a serious disorder of pregnancy, characterised by high maternal blood pressure, placental hypoxia, fluid retention (oedema) and proteinuria. Women with preeclampsia are associated with exaggerated levels of pro-inflammatory cytokines, chemokines and anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 (sFLT1). Studies in non-gestational tissues have described the bromodomain (BRD) and extraterminal family of proteins, in particular BRD4 to play a critical role in propagating inflammation and is currently a therapeutic target for treating cancer, lung inflammation and asthma. The aims of this study were to: (i) determine the effect of severe early-onset preeclampsia on placental BRD4 expression; (ii) the effect of loss of BRD4 function by siRNA-targeted knockdown or with the BRD inhibitor JQ1 in human primary trophoblast cells and human umbilical vein endothelial cells (HUVECs) on TNF-stimulated production of pro-inflammatory mediators, cell adhesion molecules and anti-angiogenic markers and (iii) the effect of BRD4 suppression on placental sFLT1 secretion under hypoxia conditions and in preeclampic placenta. BRD4 mRNA expression was significantly increased (sevenfold) in severe early-onset preeclampsia placenta. BRD4 silencing resulted in a significant reduction in TNF-induced IL6, CXCL8, CCL2, CXCL1 and sFLT1-e15a mRNA expression and IL6, CXCL8, CCL2, CXCL1 and sFLT1 secretion in primary trophoblast and HUVECs. Additionally, JQ1 treatment significantly reduced placental sFLT1 secretion under hypoxic conditions and in preterm preeclamptic placenta. In conclusion, these findings suggest BRD4 may play a central role in propagating inflammation and endothelial dysfunction associated with the pathophysiology of early-onset preeclampsia.
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Al-Gazali, Basima Shamkhi, Saba Muhammed Jassim, Abd Al-Aziz A.Aziz, and Raed F. Al-joubori. "Estimation of Umbilical Artery Resistive Index in Pregnant Women with Preeclampsia in Al-Najaf Province." JOURNAL OF UNIVERSITY OF BABYLON for Pure and Applied Sciences 27, no. 1 (April 1, 2019): 107–12. http://dx.doi.org/10.29196/jubpas.v27i1.2071.
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This study was carried out on 105 pregnant women with preeclampsia in addition to 105 pregnant women without preeclampsia as a control at Al-Najaf province from September ,2017-May 2018. All the included patients were examined by Doppler study to assess the resistive index of umbilical artery RI in preeclamptic pregnant patients with PE and pregnant women without PE. The results reveals that there was significant difference of umbilical artery RI 0.658±0.304, concerning preeclamptic pregnant patients in comparison to pregnant women without PE(0.571±0.215) , ( PV lesser than0.05) .
In addition to that the umbilical artery RI was (0.577±0.301) in preeclamptic pregnant patient with mild PE while it was (0.813±0.247) in preeclamptic pregnant patient with severe PE which displayed a statistically significant difference( PV less than0.05).Also this study showed that the umbilical artery RI in preeclamptic pregnant patients with H. pylori was(1.11±0.319) which was greater than that for preeclamptic pregnant patients without H. pylori (0.919±0.25) with a statistically significant difference ( PV less than 0.5). It was concluded that Umbilical artery resistive index is a useful parameter in detection of preeclampsia and its severity and the umbilical artery resistive index might be useful parameter in prediction of infection of positive H. pylori infection associated with preeclampsia.
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Devi, Lakshmi, Preet Banerjee, D. V. K. Durga, and Pooja Sahu. "Cross-sectional study to evaluate various cardiovascular manifestations in pregnant women with preeclampsia using 2d echocardiogram." EUREKA: Health Sciences, no. 6 (November 30, 2022): 23–30. http://dx.doi.org/10.21303/2504-5679.2022.002727.
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Preeclampsia is one of the most frequent complications found in pregnancy. Preeclampsia was initially thought to cause poor long-term cardiovascular outcomes, but recent studies have shown its effect to be more early and severe.
Aims: To reduce the morbidity and mortality for all patients with hypertension in pregnancy through any cardiovascular problem that is directly caused by hypertension in pregnancy
Methods: it is a cross-sectional and observational study of pregnant women with preeclampsia in the reproductive age group (15–44 years) diagnosed with preeclampsia in the antenatal ward/HDU/MICU at Niloufer hospital were evaluated with 2d echo on diagnosis and a follow up 2d echo after delivery was done and changes in 2d echo were noted, patients with prior changes in 2d echo have been excluded from the study. About 113 preeclamptic patients were studied and further classified as non-severe and severe preeclampsia, and their results were compared.
Results: This study shows significant cardiovascular dynamics changes in subjects with preeclampsia (both severe and non-severe) which can be studied by 2 D echo. Non-severe preeclampsia was associated with more normal birth weight. This was found statistically significant in our study. IUD and early neonatal death were more associated with severe preeclampsia when compared to non-severe preeclampsia, which was found statistically significant.
Conclusions: Early identification of preeclamptic patients at higher risk of developing cardiovascular complications later in life by undergoing timely echocardiography.
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Bairwa, Radheshyam, and Suhail Iqbal. "Serum lactate dehydrogenase (LDH) level in mild and severe preeclampsia as a prognostic marker." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 10 (September 26, 2018): 3969. http://dx.doi.org/10.18203/2320-1770.ijrcog20183890.
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Background: Lactate Dehydrogenase (LDH) is mainly an intracellular enzyme. Its level is an useful biomarker for cellular injury which may suggested as a potential marker to predict the severity of preeclampsia and indicator for multi-organ involvement have significant role in management of preeclampsia. We conducted this study to examine the relationship between lactate dehydrogenase concentration and the severity of the disease and occurrence of complications. The objective of the present study was to assess role of serum LDH level in mild and severe preeclamptic womenMethods: This prospective study was conducted in the Department of obstetrics and gynecology in Jhalawar medical college from Jan 2017 to Oct 2017 Total 120 pregnant women during third trimester (32-40 weeks) aged 18 to 35 years were selected. Among them 40 were severe preeclampsia and 40 were mild preeclampsia patients and 40 were healthy normotensive control. Serum LDH level was estimated by continuous spectrophotometric method. Demographic, hemodynamic, and laboratory data were compared among the three groups. The symptoms and complications of severe pre-eclampsia along with foetal outcome were analyzed according to the levels of LDH.Results: In this study, serum LDH level was significantly higher (P<0.001) in preeclamptic compared to those of control. Again, this value was significantly higher in severe preeclamptic than those of mild preeclamptic. The symptoms and complications of preeclampsia along with perinatal mortality were increased significantly in patents with LDH> 800IU/I compared with those who had lower levels.Conclusions: From this study, it can be concluded that elevated serum LDH level is associated with severity of preeclampsia. LDH has been evaluated as a biochemical marker for preeclampsia and as a prognosticator of the disease severity. Detection of high-risk patients with increased levels of LDH mandate close monitoring and management to prevent maternal and fetal morbidity and mortality.
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El-Samra, Mohamed Abd El-Moety, and Sherif Mansour Aggag. "Relation of serum visfatin level and uterine artery Doppler to preeclampsia." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 1 (December 25, 2017): 48. http://dx.doi.org/10.18203/2320-1770.ijrcog20175831.
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Background: Preeclampsia (PE) is a significant cause of remarkable fetomaternal morbidity and mortality worldwide. Visfatin is 52 KDa novel adipokine, pre B cell colony enhancing factor (PBEF) which could be used as a biochemical marker predictor or a diagnostic tool for preeclampsia. Trans abdominal pulsed Doppler ultrasound (US) monitor the impedance to blood flow in the uterine arteries in pregnant females and those with preeclampsia. Visfatin has been implicated in the pathogenesis of preeclampsia with a limited contradictory. The aim of our study is to monitor the risky pregnant females through Visfatin level and transabdominal pulsed Doppler of the uterine artery.Methods: Assessment of the serum Visfatin levels in the maternal circulation of preeclamptic pregnant females wether mild or severe, and compared to those in the normal pregnant subjects as control through recruitment of cases of mild PE (n=40), severe PE (n=40), normal pregnant subjects (n=60) in a cross sectional study where the cases were of the patients hospitalized at El Shatby Hospital of Obstetrics and Gynecology, and the control subjects were of referrals to the outpatient departments. Fasting blood samples were drawn, kept at -20 degree centigrades , enzyme linked immune sorbant assay (ELISA) Test was performed on them to determine the Visfatin level and recorded the uterine arteries pulsatility index through transabdominal doppler ultrasound. Lastly, the data were analysed using (F test) ANOVA statistical method.Results: Amongst the groups, Serum visfatin level was significantly higher in the severe preeclamptic group rather than the normal pregnant group and those with mild preeclampsia (p<0.001). Uterine artery pulsatility index was significantly higher in the severe preeclamptic group rather than the normal pregnant group and those with mild preeclampsia (p<0.001).Conclusions: Severe preeclamptic pregnant females were shown to represent higher circulating visfatin levels as one of the most recent biochemical markers of preeclampsia, higher uterine artery pulsatility index compared to normal pregnant and those with mild preeclamptic groups of women.
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Tahaa, Amira M., Iman B. Abd Raboub, and Hala W. Abd Halim. "The value of maternal serum levels of growth differentiation factor-15 as a predictor of preeclampsia." Scientific Journal of Al-Azhar Medical Faculty, Girls 5, no. 1 (2021): 204–10. http://dx.doi.org/10.4103/sjamf.sjamf_128_20.
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Back ground Preeclampsia is a leading cause of maternal morbidity and mortality worldwide. Growth differentiation factor-15 (GDF-15) is a stress-induced cytokine and related to the prognosis of cardiovascular diseases. It was expressed in the placentae of both normal and preeclamptic pregnancies. Objective To evaluate the value of GDF-15 as a predictor of preeclampsia and its correlation with the severity of the disease. Patients and methods This was a prospective study in which we enrolled a number of primigravidae at gestational age between 19 and 20 weeks. After complete and thorough history taking and examination in addition to basal ultrasound, serum blood samples were taken from all women and were frozen at −20°C for later assay. After Institutional Ethics Committee approval, antenatal care for all women till delivery was done. Women who developed preeclampsia, 40 of them, were chosen as the study group (group B), and 40 women who were passed the antenatal period without complications were included as the control group (group A). Results We found that serum levels of GDF-15 were higher in preeclamptic group than control group, and this reached a highly significant level. The mean±SD level of GDF-15 in the preeclamptic group was 383.42±130.67 versus 118.73±28.88 pg/ml in the control group (P=0.000). The more the severity of preeclampsia, the higher GDF-15 level, with the highest level being detected in severe–early preeclampsia. Conclusion GDF-15 is increased in preeclampsia than normal physiological pregnancy, with the highest level detected in severe–early preeclampsia.
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Irhamna, Rifka, Xela Adilla Pramesthi, Yuman Arya Nasrullah, and Minarni Wartiningsih. "Prevent Mortality Rates of Pregnant Women in Preeclampsia Condition Based on Characteristics Analysis." Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) 2, no. 3 (October 3, 2019): 95. http://dx.doi.org/10.22146/rpcpe.46872.
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Background: Preeclampsia is the leading cause of the deaths of pregnant women in Indonesia (30.9%). The cause of preeclampsia until now is not known for sure. The purpose of this study was to determine the characteristics of preeclamptic pregnant women based on age, parity, body mass index and based on a history of hypertension, family history of hypertension, and level of education.Methods: The research method is observasional descriptive. The sampling technique is total sampling. The sample in this study were preeclamptic pregnant women in Dr. Mohammad Soewandhie Hospital in the period of 1 January up to 31 Desember 2017 amounting to 100 samples.Results: The results showed that 55% of preeclampsia pregnant women aged >35 years, 65% of primipaternity preeclampsia mothers, 63% obesity, 67% had no history of hypertension, 78% had no family history of hhypertension, and level of education does not affect the condition.Conclusions and Discussions: The highest risk factors for preeclampsia are age> 35 years, primipaternity and obesity. Therefore, it needs appropriate prevention methods to avoid the emergence of pregnancy problems and their complications include recognizing the signs and symptoms of preeclampsia, be aware of risk factors for the causes of preeclampsia, routine antenatal care, and adopting a healthy lifestyle.
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Binder, Natalie K., Sally Beard, Natasha de Alwis, Bianca R. Fato, Tuong-Vi Nguyen, Tu’uhevaha J. Kaitu’u-Lino, and Natalie J. Hannan. "Investigating the Effects of Atrial Natriuretic Peptide on the Maternal Endothelium to Determine Potential Implications for Preeclampsia." International Journal of Molecular Sciences 24, no. 7 (March 24, 2023): 6182. http://dx.doi.org/10.3390/ijms24076182.
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Preeclampsia is associated with an increased lifelong risk of cardiovascular disease (CVD). It is not clear whether this is induced by persistent systemic organ and vascular damage following preeclampsia or due to a predisposition to both conditions that share cardiovascular pathophysiology. Common to both CVD and preeclampsia is the dysregulation of corin and its proteolytic product, atrial natriuretic peptide (ANP). ANP, a hypotensive hormone converted from pro-ANP by corin, is involved in blood pressure homeostasis. While corin is predominantly a cardiac enzyme, both corin and pro-ANP are significantly upregulated in the gravid uterus and dysregulated in preeclampsia. Relatively little is known about ANP function in the endothelium during a pregnancy complicated by preeclampsia. Here, we investigated the effect of ANP on endothelial cell proliferation and migration, markers of endothelial dysfunction, and receptor expression in omental arteries exposed to circulating preeclamptic toxins. ANP receptor expression is significantly upregulated in preeclamptic vasculature but not because of exposure to preeclampsia toxins tumour necrosis factor α or soluble fms-like tyrosine kinase-1. The supplementation of endothelial cells with ANP did not promote proliferation or migration, nor did ANP improve markers of endothelial dysfunction. The role of ANP in preeclampsia is unlikely to be via endothelial pathways.
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Mirzaeva, Dilfuza Botirjonovna, and Das Sharodiya. "Diagnostic and prognostic value of platelet indices as a potential biomarker in preeclampsia: a case-control study in a maternity hospital at Tashkent." International Journal of Medical Sciences And Clinical Research 5, no. 2 (February 1, 2025): 95–101. https://doi.org/10.37547/ijmscr/volume05issue02-18.
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Background: Globally, preeclampsia (PE), a serious pregnancy complication, is the cause of mother and fetal morbidity and mortality. Preeclampsia and eclampsia together account for 10 to 15% of direct maternal deaths. It is distinguished by the development of proteinuria and hypertension after 20 weeks of pregnancy. In this study, the impact of platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) on the development of preeclampsia in patients will be examined, and their relationship to the severity of the condition will be assessed. Methods: 58 pregnant women participated in a case-control study in Tashkent, with 30 age-matched normotensive controls and 28 preeclamptic (mild: n=15; severe: n=13). Results: The platelet count was lowest in patients with severe preeclampsia and considerably lower in preeclamptic patients than in controls. With a rising trend in severe preeclampsia, MPV and PDW were significantly higher in preeclampsia (p<0.001). Systolic blood pressure and MPV had a significant correlation (r=0.56, p=0.001), while PDW and hypertension had a moderate correlation (r=0.46, p=0.013). In conclusion, platelet indices—specifically MPV and PDW—have the potential to serve as indicators of preeclampsia severity. In clinical practice, their prognostic implications can aid in early risk assessment and management, thereby averting imminent eclampsia.
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Pradhan, P. "Role of Angiogenic Factors in Preeclampsia." Nepal Journal of Obstetrics and Gynaecology 9, no. 1 (September 28, 2014): 71–73. http://dx.doi.org/10.3126/njog.v9i1.11194.
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Preeclampsia, the syndrome of hypertension, proteinuria, edema and hyperuricemia occurring during the last trimester of pregnancy remains one of the great mysteries. Recently gene expression profiling of placental tissue from healthy and preeclamptic women used to see which genes were up or down regulated in preeclamptic patients. Alterations in circulating angiogenic proteins correlated with disease severity, earlier onset of preeclampsia and birth of small for gestational age (SGA) fetus. These findings lend support to the hypothesis that circulating angiogenic proteins may have an important biological role in preeclampsia. DOI: http://dx.doi.org/10.3126/njog.v9i1.11194 NJOG 2014 Jan-Jun; 2(1):71-73
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Parvin, Salma, Humaira Hoque, Salma Akhtar Walida, and Shabnam Banu. "Association of Serum Lactic Dehydrogenase Level with Severity of Preeclampsia." Ibrahim Cardiac Medical Journal 12, no. 1 (November 15, 2023): 46–51. http://dx.doi.org/10.3329/icmj.v12i1.69794.
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Background & objective: : The present study was undertaken to measure the levels of lactic dehydrogenase (LDH) in normal pregnancy, mild preeclampsia and severe preeclampsia and compare them among the three groups of women. Methods: This cross-sectional analytical study was carried out in the Department of Obstetrics & Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, between January 2014 to December 2014. A total of 120 pregnant women admitted in the above-mentioned hospital were included in the study. Pregnant women with blood pressure ≥140/90 mmHg and proteinuria ≥ 0.3 gm/24 hours were included in the study as case, while pregnant women with normal blood pressure without proteinuria were included as control. Of them 40 women were mildly preeclamptic, 40 severely preeclamptic and 40 were normal pregnant women. While preeclampsia was exposure variable, the outcome variable was LDH level. Lactic Dehydrogenase (LDH) level was measured in all the study subjects. Pregnant women with diabetes, chronic renal disease, hepatic disease, systemic infection and systemic lupus erythematosus, cardiovascular disease, essential hypertension, thyroid disorder and hemorrhagic disorders were excluded. Result: The case and control groups were almost similar with respect to age with mean age of the cases and controls being 26.1 and 27.2 years respectively (p = 0.272). However, preeclamptic patients were comparatively heavy than the normal pregnant women (31.4 ± 7.5 vs. 26.3 ± 3.1 kg/m2) (p = 0.001). The preeclamptic women exhibited significantly raised serum LDH level than their normal counterparts did (561.4 ± 301.2 vs. 270.2 ± 89.3 U/L, p = 0.001). More than half (52.5%) of the severe preeclamptic women had LDH ≥ 600 U/L as opposed to only 17.5% of the mild preeclamptic patients with risk of having raised LDH in severe preeclamptic patients being > 5-fold (95% CI of OR = 1.8 – 14.5) higher than that in the mild preeclamptic patients (p = 0.001). The LDH level was also found to increase with increasing severity of preeclampsia (p < 0.001). Both systolic and diastolic blood pressures of mild and severe preeclamptic patients had significantly linear correlations with serum LDH levels. Proteinuria in preeclamptic patients were also significantly correlated with LDH level (r = 0.636, p = 0.001). Categorically both systolic and diastolic blood pressures in severe form of preeclampsia were associated with higher level of LDH (> 800 U/L) (p = 0.003 and p = 0.012 respectively). Conclusion: The study concluded that LDH level increases in preeclampsia patients and rise of serum LDH is associated with severity of preeclampsia. Ibrahim Card Med J 2022; 12 (1): 46-51
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Wulandari, Priharyanti. "FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN PREEKLAMSIDI PUSKESMAS SUMBER KABUPATEN REMBANG." Jurnal Ilmiah Keperawatan Indonesia [JIKI] 1, no. 2 (March 19, 2018): 83. http://dx.doi.org/10.31000/jiki.v1i2.412.
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ABSTRAK Preeklamsi adalah penyakit yang ditandai dengan hipertensi, proteinuria, dan oliguria. Preekalmsi disebabkan beberapa faktor seperti usia ibu, paritas, riwayat preeklamsi, dan jarak kehamilan. Setelah dilakukan wawancara di Puskesmas Sumber Kabupaten Rembang dengan 9 ibu hamil, 6 mengatakan memilliki riwayat preeklamsi, hipertensi sebelumnya, dan 1 ibu hamil tidak memiliki faktor resiko preeklamsi.Desain penelitian ini Kuantitatif Deskriptif Korelasional. Desain penelitian menggunakan Crosectional. Populasi penelitian ini semua ibu hamil di Puskesmas Sumber Kabupaten Rembang dengan sampel sejumlah 31responden menggunakan teknik Accidental Sampling serta pengumpulan data menggunakan lembar kuesioner dan analisis uji bivariat menggunakan uji chi square.Hasil penelitian menunjukkan bahwa faktor usia dengan kejadian preeklamsi dengan jumlah reponden yang berisiko (<20&>35 tahun ) sebanyak 22 (71,0%) yang preeklamsi, umur berisiko sebanyak 3 (9,7%) yang tidak preeklamsi, dan umur yang tidak berisiko (20-35 tahun) sebanyak 3 (9,7%) yang preeklamsi, umur tidak berisiko sebanyak 3 (9,7%) yang tidak preeklamsi didapatkan nilai pvalue= 0,034 <0,05. Faktor paritas yang berisiko (≥3 kali) yang mengalami preeklamsi sebanyak 11 (35,3%) responden, faktor paritas berisiko (≥3 kali) yang tidak preeklamsi sebanyak 6 (19,45), dan paritas <3kali yang mengalami preeklamsi sebanyak 14 orang (45,1%) didapatkan nilai pvalue= 0,o13 <0,05. Faktor riwayat preeklamsi yang memiliki riwayat dengan jumlah 12 orang (38,7%) preeklamsi, dan ibu yang tidak memiliki riwayat namun mengalami preeklamsi sebanyak 13 (41,9% serta 6 orang (19,4%) tidak preeklamsi didapatkan nilai pvalue= 0,030 <0,05. Faktor jarak kehamilan yang berisiko (≤2 tahun ) yang mengalami preeklamsi sebanyak 17 (54,8%), jarak kehamilan berisiko (≤2 tahun tidak preeklamsi sebanyak 3 (9,75), jarak kehamilan tidak berisiko (>2 tahun) yang preeklamsi sebanyak 8 responden (25,8%), jarak kehamilan tidak berisiko yang tidak preeklamsi sebanyak 3 (9,75). Dari 4 faktor tersebut didapatkan faktor (usia, paritas, riwayat preeklamsi) ada hubungannya dengan kejadian preeklamsi di Puskesmas Sumber Kabbupaten Rembang. Dan faktor jarak kehamilan tidak berhubungan dengan kejadian preeklamsi karena nillai pvalue= >0,05.Kata Kunci : Faktor-faktor preeklamsi, dan kejadian preeklamsiABSTRACT Preeclampsia is a disease characterized by hypertension, proteinuria, and oliguria. Preecalmtion is due to several factors such as maternal age, parity, preeclampsia history, and gestational distance. After interviewing at Puskesmas Sumber Kabupaten Rembang with 9 pregnant women, 6 said memilliki history preeklamsi, previous hypertension, and 1 pregnant women do not have risk factor of preeklamsi. The design of this study is Quantitative Descriptive Correlational. Research design using Crosectional. The population of this study were all pregnant women in Puskesmas Sumber Kabupaten Rembang with sample of 31 responden using Accidental Sampling technique and data collection using questionnaire sheet and bivariate test analysis using chi square test. The results showed that age factor with preeclampsia incidence with the number of respondents at risk (<20 &> 35 years) was 22 (71.0%) with preeclampsia, risky age of 3 (9.7%) not preeclampsed, and age not At risk (20-35 years) as many as 3 (9.7%) of preeclampsia, age not risk as much as 3 (9.7%) not preeklamsi obtained pvalue = 0,034 <0,05. Risk factor (≥3 times) with preeclampsia was 11 (35.3%), risk factor (≥3 times), preeclampsia was 6 (19,45), and parity <3 times with preeclampsia of 14 People (45,1%) got value pvalue = 0, o13 <0,05. The history factor of preeclampsia with history of 12 people (38,7%) preeclampsia, and mothers with no history but 13 preeclampsia (41,9% and 6 persons (19,4%) did not preeclampsed pvalue = 0,030 <0,05 Risk of gestational distance (≤2 years) with preeclampsion of 17 (54.8%), risky gestational distance (≤ 2 years not preeclamped as much as 3 (9.75), non-risk pregnancy distance (> 2 years) with preeclampsia as many as 8 respondents (25.8%), non-preeclamped pregnancy spacing of 3 (9.75) .The 4 factors (age, parity, history of preeclampsia) were related to preeclampsia occurrence in Puskesmas Sumber Kabbupaten Rembang And the distance factor of pregnancy is not related to preeclampsia occurrence because nillai pvalue => 0,05Keywords : Preecclampsia factors, and occurrence of preeclampsia
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TAŞIN, Cuma, Nezaket KADIOGLU, Revan Sabri CİFTCİ, Ayhan COSKUN, and Hakan AYTAN. "The role of platelet mass index in the prediction of preeclampsia full." Journal of Experimental and Clinical Medicine 39, no. 1 (January 1, 2022): 221–25. http://dx.doi.org/10.52142/omujecm.39.1.43.
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To assess the possible roles of platelet indices including platelet mass index (PMI), platelet count (PC), mean platelet volume (MPV) and PC/MPV in prediction of preeclampsia. 190 pregnant women diagnosed with preeclampsia and 100 healthy uncomplicated control patients were included in this retrospective study. Age, gestational week, fetal weight, alanine transaminase (ALT), aspartate transaminase (AST), creatinine, blood urea nitrogen (BUN), complete blood count parameters and platelet indices were compared. ROC curve was applied to analyze the cut-off values of the significantly differing parameters for prediction of preeclampsia. Preeclamptic patients gave birth significantly earlier than the controls. In preeclamptic patients, the mean values of PC, PC / MPV and PMI were significantly lower than the control group. Although mean MPV values were lower in preeclampsia patients, the difference was not significant. The cut-off values of PC, PC/MPV and PMI were found to be 207,500, 18448.16 and 2411.75 with a-sensitivity/specificity of 45.3%/ 44.3%, 42.2%/ 42.6% and 44.1%/ 44.3%, respectively. Indices such as PC, PC / MPV and PMI changed significantly in preeclampsia. Although they have low sensitivity and specificity, these indices can be combined with other parameters and used in the prediction of preeclampsia.
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ERDOGAN, Gamze, Yusuf NERGİZ, and Elif AĞAÇAYAK. "HISTOLOGICAL AND HISTOCHEMICAL EVALUATION OF NORMOTENSIVE AND PREECLAMPTIC PLACENTAS." International Journal of Health Services Research and Policy 4, no. 1 (April 1, 2019): 67–73. http://dx.doi.org/10.33457/ijhsrp.533771.
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The placenta plays a role in the pathophysiology of preeclampsia. Preeclampsia is more common in multifetal pregnancies than singleton pregnancies. In this study, we aimed to investigate the histopathology of normotensive and preeclamptic placentas and the localization of alkaline phosphatase activity. In our study, 10 normotensive and 10 preeclamptic, totally 20 placentas were obtained.Paraffin sections were stained with Hematoxylin-Eosin, Masson trichrome and PAS for histopathological examination.Remaining sections were then stained via Gomori’s method and micrographed under light microscope. Sections of the control group observed normal histologically structure.The alkaline phosphatase reaction was evident in the inner and outer membranes of the syncytiotrophoblasts. There was a significant increase in the number of syncytial knots, terminal villi and syncytial bridges in the preeclamptic placenta sections. Marked thickening of the trophoblast basal membranes were observed. Alkaline phosphatase reaction in preeclampsia group: The localization of alkaline phosphatase in the inner and outer membranes of the syncytiotrophoblasts was reduced. In placentas of preeclampsia group, a significant increase in syncytial knot, syncytial bridge were observed. The level of alkaline phosphatase enzyme in preeclamptic placentas was found to be lower compared to normotensive placenta.
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Nath, Meryl C., Hajrunisa Cubro, Daniel J. McCormick, Natasa M. Milic, and Vesna D. Garovic. "Preeclamptic Women Have Decreased Circulating IL-10 (Interleukin-10) Values at the Time of Preeclampsia Diagnosis." Hypertension 76, no. 6 (December 2020): 1817–27. http://dx.doi.org/10.1161/hypertensionaha.120.15870.
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A key immunomodulatory cytokine, IL-10 (interleukin-10), has been shown to be dysregulated in preeclampsia, a pregnancy-specific hypertensive disorder, further characterized by multi-system involvement. However, studies have reported inconsistent findings about circulating IL-10 levels in preeclamptic versus normotensive pregnancies. The aim of the present systematic review and meta-analysis was to assess circulating IL-10 levels in preeclamptic and normotensive pregnancies at 2 time points: before, and at the time of preeclampsia diagnosis. PubMED, EMBASE, and Web of Science databases were searched to include all published studies examining circulating IL-10 levels in preeclamptic and normotensive pregnancies. Differences in IL-10 levels were evaluated by standardized mean differences. Of 876 abstracts screened, 56 studies were included in the meta-analysis. Circulating IL-10 levels were not different before the time of active disease (standardized mean differences, −0.01 [95% CI, −0.11 to 0.08]; P =0.76). At the time of active disease, women with preeclampsia (n=1599) had significantly lower IL-10 levels compared with normotensive controls (n=1998; standardized mean differences, −0.79 [95% CI, −1.22 to −0.35]; P =0.0004). IL-10 levels were lower in both early/severe and late/mild forms of preeclampsia. Subgroup analysis revealed that IL-10 measurement methodology (ELISA or multiplex bead array) and the sample type (plasma or serum) significantly influenced the observed differences, with the use of sera paired with ELISA technology providing the best distinction in IL-10 levels between preeclamptic and normotensive pregnancies. These findings support the role of decreased IL-10 levels in the pathophysiology of preeclampsia. Future studies should address the therapeutic potential of IL-10 in preeclampsia.
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Simmons, Lisa A., Adrian G. Gillin, and Richmond W. Jeremy. "Structural and functional changes in left ventricle during normotensive and preeclamptic pregnancy." American Journal of Physiology-Heart and Circulatory Physiology 283, no. 4 (October 1, 2002): H1627—H1633. http://dx.doi.org/10.1152/ajpheart.00966.2001.
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Increased cardiac output in pregnancy is associated with cardiac remodeling and possible reduction in contractility, which may worsen in preeclampsia. Left ventricular (LV) geometry and function were compared between nonpregnant controls ( n = 12) and normotensive ( n = 44) and preeclamptic ( n = 15) pregnant women using echocardiography. Load-independent comparisons of LV systolic function compared end-systolic stress (ESS) and rate-corrected velocity of circumferential fiber shortening ( VCFC). Mean arterial pressures were 101 ± 14 mmHg in preeclampsia, 76 ± 6 mmHg in normotensive pregnancy, and 78 ± 6 mmHg in controls ( P < 0.005 vs. preeclampsia). LV mass increased during normotensive pregnancy (66 ± 13 to 76 ± 16 g/m2; P < 0.05; controls, 65 ± 10 g/m2; P < 0.05) and was greater in preeclampsia (90 ± 18 g/m2; P < 0.05). In normotensive pregnancy, ESS decreased (59 ± 9 to 52 ± 11 g/cm2; P < 0.05; controls, 66 ± 14 g/cm2; P < 0.005). ESS was greater in preeclampsia (60 ± 14 g/cm2; P < 0.05). In controls, there was an inverse relationship between ESS and VCFC( r = −0.78). The ESS- VCFCrelationships in normotensive and preeclamptic pregnancy were unchanged from controls. We conclude that LV hypertrophy in normotensive and preeclamptic pregnancy matches changes in cardiac work, and LV contractility is preserved.
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Hussien, Nahed Ahmed, Nazia Shuaib, Zeinab Ali Baraia, Adel Omar Laradhi, Wenna Wang, and Zhenxiang Zhang. "Perceived Cardiovascular Disease Risk Following Preeclampsia: A Cross-Sectional Study." Healthcare 11, no. 16 (August 21, 2023): 2356. http://dx.doi.org/10.3390/healthcare11162356.
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Preeclampsia has been linked to an increased risk of cardiovascular disease (CVD), and the preeclamptic women were unaware of this link. Therefore, this study aims to assess women’s knowledge and perception of future CVD after preeclampsia. This study used a cross-sectional descriptive design. Two hundred and forty-six women with a preeclampsia history were recruited from the Al Salam MCH Center and Suez Canal University Hospital. Data were collected during March 2022 using a socio-demographic questionnaire, an Adapted Coronary Heart disease knowledge tool for preeclamptic women, and The Perception of Risk of Heart Disease Scale (PRHDS). Most women (96%) were unaware of the relationship between CVD and preeclampsia. The women had a low CVD knowledge level (10.26 ± 6.08) as well as a low perception of cardiovascular disease risk (37.15 ± 7.22). There was a significant positive correlation between CVD knowledge and CVD risk perception (r = 0.434, p = 0.000). This study found that preeclampsia survivors underestimated their CVD risk. Based on these findings, preeclamptic women should receive health education sessions on CVD risk and prevention from their nurses and obstetricians. The hospital pre-discharge plan must contain these sessions in written and electronic formats to help women remember and follow CVD risk reduction measures.
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Öcal, Ece, Veysel Toprak, Senem Alkan Akalin, Firat Aşir, and Engin Deveci. "Investigation of Beclin 1 and TNF-α expressions in preeclampsia placentas: Immunohistochemical study." Medicine 102, no. 33 (August 18, 2023): e34757. http://dx.doi.org/10.1097/md.0000000000034757.
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Background: Preeclampsia is a pregnancy complication Aim of this study was to investigate expression of Beclin1 and tumor necrosis factor (TNF)-α in normotensive and preeclamptic placentas of pregnant women patients. Methods: Twenty normotensive and 20 preeclamptic patients placentas were dissected for paraffin- wax processing. Placental samples were embedded in parafin blocks. Sections were stained with Hematoxylin-Eosin staining and TNF-α and Beclin1 immunostaining. Results: In control group, root and floating villi were normal in histological perspectives, syncytial node number was low, vessels were normal with connective tissue. No hemorrhage was observed in the intervillous area. In preeclampsia group, decidual cell degeneration and fibrinoid accumulation increased. Vascular dilatation and congestion with mononuclear cell infiltration were observed. Beclin1 reaction was generally negative in control group. In preeclampsia group, Beclin1 reaction was increased in decidual cells, syncytial nodes and bridges and in chorionic villi and in some Hoffbauer cells. In control group, TNF-α expression was mainly negative but only in some decidual cells. In preeclampsia, TNF-α reaction was observed in degenerated decidua cells, in leukocytes and in villi. Conclusion: In preeclampsia placentas, degenerated decidua cells and inflammation increased. It was thought that Beclin1 and TNF-α signals could be used as a marker in affecting the fetal structure of blood flow in preeclamptic placentas.
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Akhter, Nasima, M. Azharur Rahman, Ashik Mahmud, Saima Rahman, and Rabab Sultana. "The association of serum ferritin with preeclampsia and its severity." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 13, no. 4 (March 28, 2024): 853–56. http://dx.doi.org/10.18203/2320-1770.ijrcog20240777.
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Background: Preeclampsia, a pregnancy-related condition with heightened blood pressure and organ damage after 20 weeks, prompts concern. Serum ferritin, an iron-storing protein, gauged by blood tests, mirrors iron levels. Investigating link before conception between serum ferritin and preeclampsia could impact how we identify, manage, and treat this condition during pregnancy. Study aimed to assess the association of serum ferritin with preeclampsia and its severity. Methods: This case-control study was conducted in Bangabandhu Sheikh Mujib medical university hospital and Dhaka medical college hospital, Dhaka, Bangladesh from July 2011 to June 2012. A total of 100 pregnant women, comprising 50 cases (Preeclamptic) and 50 controls (Normal pregnant women), were purposively included as study subjects. Data analysis was performed using SPSS version 23.0. Results: In the case group, 64% were with mild and 36% with severe preeclampsia. Mean serum ferritin was significantly higher in cases than in controls (p<0.001); 76% of cases had elevated serum ferritin, compared to 44% in controls (p=0.001). Severe preeclampsia group had a mean serum ferritin of 192.8, mild preeclampsia group had 86.1, and normal pregnant women had 21.7 ng/ml, indicating higher serum ferritin with preeclampsia severity (p<0.001). Conclusions: Preeclamptic cases exhibit significantly elevated serum ferritin levels, with a fourfold increased likelihood compared to normal pregnancies. Furthermore, the severity of preeclampsia is associated with higher serum ferritin concentrations in comparison to uncomplicated pregnancies.
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Drury-Stewart, Danielle N., Kara K. Hoppe, Kerry W. Lannert, Dominic W. Chung, Hilary S. Gammill, and Jill M. Johnsen. "Pregnancies Complicated By Severe Preeclampsia Exhibit Perturbed Von Willebrand Factor (VWF)-Associated Parameters." Blood 122, no. 21 (November 15, 2013): 3525. http://dx.doi.org/10.1182/blood.v122.21.3525.3525.
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Abstract Background Elevated levels of the critical coagulation glycoproteins von Willebrand Factor (VWF) and Factor VIII (FVIII) are associated with thrombovascular disease. VWF and FVIII levels are elevated in healthy pregnancy compared with the nonpregnant state, and further increases have been reported in pregnancies complicated by preeclampsia, a potentially life-threatening vascular disorder of pregnancy. Aside from the quantitative increases in VWF and FVIII, data is inconsistent or little is known regarding other key VWF-associated parameters in pregnancies complicated by preeclampsia. Hypothesis We hypothesized that pregnancies complicated by severe preeclampsia would exhibit distinct changes in VWF-associated parameters compared to healthy pregnancies. Methods We assayed VWF-associated parameters in subjects newly diagnosed with severe preeclampsia, based on standard blood pressure (BP) and proteinuria criteria. Severe preeclampsia was defined on the basis of one or more of the following: severe hypertension (systolic BP >160 or diastolic BP >110) for at least 6 hours, seizures (eclampsia), hemolysis, elevated liver enzymes, thrombocytopenia, pulmonary edema, renal dysfunction, or fetal growth restriction. We compared results from preeclamptic pregnancies to gestational age-matched healthy pregnant controls. VWF antigen (VWF:Ag), VWF propeptide (VWF:pp), and FVIII antigen (FVIII:Ag) levels were determined by ELISA. Factor VIII activity (FVIII:C) was measured using a one-stage assay and ADAMTS13 activity was determined via cleavage of an enzyme-linked peptide substrate. Results Forty-two patients with severe preeclampsia and a cohort of thirty-nine controls of similar gestational ages met study inclusion criteria (Table 1). The results of the coagulation assays are presented in Table 2. In summary, preeclamptic pregnancies were notable for statistically significant (p<0.001) increases in VWF:Ag (1.4-fold), VWF:pp (1.5-fold), and FVIII:Ag (1.2-fold) compared to controls. FVIII:Ag and FVIII:C were similar, and FVIII:Ag was used in the calculation of the VWF:FVIII ratio. The VWF:FVIII ratio trended higher in preeclamptic pregnancies, but this did not reach statistical significance (p=0.058). The mean ADAMTS13 activity in patients with preeclampsia was also significantly lower (0.76-fold, p<0.001) than healthy pregnancy controls. Conclusions In pregnancies complicated by severe preeclampsia, VWF:Ag and FVIII were significantly elevated, as expected. VWF:FVIII ratios also tended to be higher in preeclamptic pregnancies compared to controls. Interestingly, activity of the VWF-cleaving protease ADAMTS13 was modestly but significantly decreased in preeclampsia pregnancies, a finding for which there is conflicted literature. Three subjects with thrombocytopenia had ADAMTS13 activities >85%, indicating the thrombocytopenia was unrelated to a relative ADAMTS13 deficiency. These findings support the hypothesis that pregnancies complicated by severe preeclampsia exhibit VWF biology that is distinct from healthy pregnancy. We speculate that preeclampsia-associated VWF differences could play a direct role in the vascular pathogenesis and end-organ damage of preeclampsia. These data offer new clues towards better understanding of the mechanisms of severe preeclampsia and represent promising future targets for diagnosis and/or treatment. Disclosures: No relevant conflicts of interest to declare.
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Stefanović, Milan, Predrag Vukomanović, Mileva Milosavljević, Ranko Kutlešić, Jasmina Popović, and Aleksandra Tubić-Pavlović. "Insulin Resistance and C-reactive Protein in Preeclampsia." Bosnian Journal of Basic Medical Sciences 9, no. 3 (August 20, 2009): 235–38. http://dx.doi.org/10.17305/bjbms.2009.2813.
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Preeclampsia is referred to as the “disease of the theories” because of the multiple hypotheses proposed to explain is occurrence. Despite considerable research, the causes of preeclampsia remain unclear. Preeclampsia is likely to be multifactorial in origin, and recent research has focused on endothelial dysfunction as a central abnormality in preeclampsia. Insulin resistance and inflammation may contribute to the onset of preeclampsia. They could also be correlated. The aim of the study was to evaluate the presence and relationship between insulin resistance and its markers and C-reactive protein as a marker of inflammation. During their third trimester, 17 preeclamptic women and 20 normotensive controls underwent oral glucose tolerance test, basic biochemical analyses and SHBG. Preeclamptic women were more insulin resistant (p=0,004), and they had higher triglycerides levels (p=0,006), uric acid (p=0,002). However, the study groups did not differ in C-reactive protein (CRP), sex hormone-binding globulin (SHBG), high and low-density lipoproteins (HDL-cholesterol and LDL-cholesterol). In multiple regression analysis only SHBG (p=0,014) and triglycer-ides (p=0,003) were associated with insulin sensitivity independently of the body mass index (BMI), weight gain, HDL and LDL, and CRP. Preeclampsia is a state of increased insulin re- sistance, and CRP as the marker of inflammation was not increased in our research, and not associated with established preeclampsia.
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WANG, Tao, Yan-yun WANG, Rong ZHOU, Chang-ping SONG, Wei LIN, Xiao-yu NIU, Lin ZHANG, and Huai-zhong HU. "Bioactive proteins in healthy pregnancies and preeclampsia: relevance to hypertension and proteinuria." Chinese Medical Journal 126, no. 11 (June 5, 2013): 2015–20. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20122800.
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Background Bioactive proteins, such as cytokines and chemokines, have not been systematically evaluated in healthy and preeclamptic pregnancies. We aimed to investigate the difference of these proteins between healthy and preeclamptic pregnancies in order to help clarify their potential roles in the pathogenesis of hypertension and proteinuria in preeclampsia. Methods Samples of amniotic fluid and maternal/umbilical cord blood were collected from normal pregnancies and women with preeclampsia for examination of bioactive proteins. Fifty-three pregnant women were enrolled in this study. Of them, 30 pregnant women were recruited as healthy controls, and 23 pregnant women were diagnosed with preeclampsia. An antibody array was used to screen for higher levels of cytokines and related proteins in amniotic fluid than in the blood samples, and these proteins were then selected for quantification by immunoassay. Results Interleukin-1 receptor 4, hepatocyte growth factor, and urokinase plasminogen activator receptor were significantly elevated in the blood of preeclampsia patients. In particular, interleukin-1 receptor 4 was 8-fold higher in preeclampsia patients than in the healthy pregnancies. Moreover, in cord blood samples hepatocyte growth factor and interleukin-8 were significantly higher in preeclampsia patients. Conclusions Because of the biologic activities, Interleukin-1 receptor 4, hepatocyte growth factor, urokinase plasminogen activator receptor and interleukin-8 in maternal and/or cord blood could play a role in the pathogenesis of hypertension and proteinuria in preeclampsia.
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Sharodiya Das and Dilfuza Botirjonovna Mirzaeva. "Diagnostic and prognostic value of Platelet Indices as a potential biomarker in Preeclampsia: A Case-Control Study in a maternity hospital at Tashkent." International Journal of Science and Research Archive 14, no. 3 (March 30, 2025): 398–403. https://doi.org/10.30574/ijsra.2025.14.3.0640.
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Background: Preeclampsia (PE) is a significant pregnancy complication which is responsible for maternal and fetal morbidity and mortality worldwide. Overall 10 to 15% of direct maternal mortality is linked with preeclampsia and eclampsia. It is characterized by the new onset of hypertension and proteinuria after 20 weeks of gestation period. The objective of this study is to analyse whether platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) is involved in the onset of preeclampsia in patients and evaluate their correlation with the severity of disease. Methods: A case-control study was conducted at Tashkent in 58 pregnant women, among them 28 was preeclamptic (mild: n=15, severe: n=13) and 30 age-matched normotensive controls. Platelet indices on complete blood count (CBC). Data was analyzed using MS-excel and SPSS. Results: Platelet count was significantly low in preeclamptic patients compared to controls, lowest in severe preeclampsia. MPV and PDW were grossly elevated in preeclampsia (p<0.001) with an increasing trend in severe preeclampsia. MPV was positively correlated with systolic blood pressure (r=0.56, p=0.001), while PDW also moderately correlated with hypertension (r=0.46, p=0.013). Conclusion: Platelet indices, particularly MPV and PDW, can be used as potential severity markers in preeclampsia. Their prognostic implications in clinical practice can help in early risk stratification and management and prevent impending eclampsia.
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Adhikari, Shree Prasad, and Jewan Pariyar. "CORRELATION BETWEEN 12-HOUR AND 24-HOUR URINE TOTAL PROTEIN IN PREGNANT WOMEN WITH PREECLAMPSIA." Journal of Chitwan Medical College 9, no. 4 (December 27, 2019): 57–60. http://dx.doi.org/10.54530/jcmc.72.
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Background: Although 24-hour urine total protein (UTP) measurement is the gold standard method for detecting proteinuria in preeclamptic women, the procedure is lengthy and time consuming that might result in delay in diagnosis of the condition. This study aimed at determining the correlation between these 2 parameters.
Methods: This was a cross-sectional study done on 50 pregnant women with preeclampsia admitted at Bharatpur Hospital from September 2018 - January 2019. Patient with preeclampsia and having albumin ≥1 on urine dipstick, the sample was collected in every 12 hours interval on two separate well labeled container with the assistance of nursing staff. Total urine protein at 12-hour and 24-hour were measured by spectrophotometric method. The data were analyzed using SPSS version 21. Correlation between the 2 measurements was analyzed using Spearman’s rank correlation coefficient. p<0.01 was considered to be statistically significant.
Results: The age of participants ranged between 20-38 years (Mean age: 26.6 years). The maximum occurrence of preeclampsia was observed in primigravid women and younger age group (between 20-25 years), 72% had mild preeclampsia and 28% developed severe preeclampsia. There was a significant correlation between 12-hour and 24-hour UTP (Spearman’s r = 0.99, p<0.001).
Conclusions: There is a strong correlation between 12- and 24-hour urine total protein measurements in women with preeclampsia. 12-hour UTP can be used as an alternative for the assessment of proteinuria in these women, with benefits such as early diagnosis and better patient compliance.
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Adhikari, Shree Prasad, and Jewan Pariyar. "Correlation between 12-hour and 24-hour urine total protein in pregnant women with preeclampsia." Journal of Chitwan Medical College 9, no. 4 (December 27, 2019): 57–60. http://dx.doi.org/10.3126/jcmc.v9i4.26903.
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Background: Although 24-hour urine total protein (UTP) measurement is the gold standard method for detecting proteinuria in preeclamptic women, the procedure is lengthy and time consuming that might result in delay in diagnosis of the condition. This study aimed at determining the correlation between these 2 parameters.
Methods: This was a cross-sectional study done on 50 pregnant women with preeclampsia admitted at Bharatpur Hospital from September 2018 - January 2019. Patient with preeclampsia and having albumin ≥1 on urine dipstick, the sample was collected in every 12 hours interval on two separate well labeled container with the assistance of nursing staff. Total urine protein at 12-hour and 24-hour were measured by spectrophotometric method. The data were analyzed using SPSS version 21. Correlation between the 2 measurements was analyzed using Spearman’s rank correlation coefficient. p<0.01 was considered to be statistically significant.
Results: The age of participants ranged between 20-38 years (Mean age: 26.6 years). The maximum occurrence of preeclampsia was observed in primigravid women and younger age group (between 20-25 years), 72% had mild preeclampsia and 28% developed severe preeclampsia. There was a significant correlation between 12-hour and 24-hour UTP (Spearman’s r = 0.99, p<0.001).
Conclusions: There is a strong correlation between 12- and 24-hour urine total protein measurements in women with preeclampsia. 12-hour UTP can be used as an alternative for the assessment of proteinuria in these women, with benefits such as early diagnosis and better patient compliance.
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Başar, Günay, Uğur Parlatan, Şeyma Şeninak, Tuba Günel, Ali Benian, and İbrahim Kalelioğlu. "Investigation of Preeclampsia Using Raman Spectroscopy." Spectroscopy: An International Journal 27 (2012): 239–52. http://dx.doi.org/10.1155/2012/376793.
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Preeclampsia is associated with increased perinatal morbidity and mortality. There have been numerous efforts to determine preeclampsia biomarkers by means of biophysical, biochemical, and spectroscopic methods. In this study, the preeclampsia and control groups were compared via band component analysis and multivariate analysis using Raman spectroscopy as an alternative technique. The Raman spectra of serum samples were taken from nine preeclamptic, ten healthy pregnant women. The Band component analysis and principal component analysis-linear discriminant analysis were applied to all spectra after a sensitive preprocess step. Using linear discriminant analysis, it was found that Raman spectroscopy has a sensitivity of 78% and a specificity of 90% for the diagnosis of preeclampsia. Via the band component analysis, a significant difference in the spectra of preeclamptic patients was observed when compared to the control group. 19 Raman bands exhibited significant differences in intensity, while 11 of them decreased and eight of them increased. This difference seen in vibrational bands may be used in further studies to clarify the pathophysiology of preeclampsia.
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Levani, Yelvi. "PENGGUNAAN PENANDA BIOLOGIS ANGIOGENIK RASIO s-Flt1 DAN PIGF SEBAGAI PREDIKTOR PREEKLAMSIA." Medical and Health Science Journal 3, no. 1 (March 1, 2019): 1–6. http://dx.doi.org/10.33086/mhsj.v3i1.920.
Full textAbstract:
Preeclampsia is a leading cause of maternal death worldwide. Preeclampsia involves multi-organ and characterized by hypertension and proteinuria. One of the hypothesis pathogenesisin preeclampsia is placental insufficiency. Its causing imbalance between angiogenic and antiangiogenic factors in maternal circulation. This imbalance factors are responsible for systemic vasoconstriction. However, until now, there is no predictor for preeclampsiain high risk pregnancy. Therefore, this review briefly describes the recent studies about utility of biologic angiogenesis marker, such as s-Flt1 and PIGF as predictor in preeclampsia