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Dissertations / Theses on the topic 'Pregnancy Complications'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Benton, Samantha Jayne. "Angiogenic factors in placentally-mediated pregnancy complications." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50014.

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Placentally-mediated pregnancy complications include pre-eclampsia, intrauterine growth restriction (IUGR), placental abruption and some causes of stillbirth. These complications are believed to arise from abnormal placental development in early gestation that leads to compromised placental function in later pregnancy which can adversely affect both mother and fetus. It is a priority in obstetrics to identify these pregnancies early and accurately so that appropriate monitoring and intervention can optimise outcomes for these mothers and babies. Novel biomarkers such as angiogenic factors in t

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2

ElMoursi, Mohamed Saad Elsayed. "Quantification of placental dysfunction in pregnancy complications." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/17262/.

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Background The pathogenetic mechanisms behind placental dysfunction-related complications like preeclampsia and intrauterine growth restriction have remained perplexing till now, in part because of lack of well-defined structural and functional molecular characterisation. There is growing evidence that links trophoblast debris and the existence of syncytial nuclear aggregates (SNA) to the pathogenesis of gestational diseases. Characterisation and quantification of structural and functional parameters of placental dysfunction may give researchers a clearer picture of the mechanisms underlying t

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3

Rodie, Vanessa Angela. "Metabolic complications of pregnancy and cardiovascular disease risk." Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421118.

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4

Demetriou, Charalambos. "Investigating genetic factors associated with complications of pregnancy." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/30728.

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This PhD project sets out to investigate the role of genetic factors associated with fetal growth restriction and recurrent miscarriage (RM), two of the most common complications of pregnancy. This work studied large cohorts of patients collected from specialist clinics in West London with the aim of better understanding their underlying molecular aetiology. The first part of this project focused on the paternally expressed, maternally imprinted gene, IGF2, which is a key growth hormone critical for in utero growth in mice. Its role in human fetal growth has remained ambiguous, as it has only

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5

Bayingana, Claude. "The prevalence of members of the "red complex" in pregnant women as revealed by PCR and BANA hydrolysis." Thesis, University of the Western Cape, 2005. http://etd.uwc.ac.za/index.php?module=etd&amp.

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Increased levels of oestrogen and progesterone during pregnancy may lead to periodontal disease. The anaerobic Gram-negative bacteria called red complex (Porphyromonas gingivalis, Tannerella forsythensis and Treponema denticola) are frequently associated with periodontal disease. Periodontopathogens produce toxins and enzymes which can enter the bloodstream and cross the placenta to harm the foetus. The response of the mother&rsquo<br>s immune system to infection by these periodontopathogens, brings about the release of inflammatory mediators which may trigger preterm labour or result in low b

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6

Björklund, Anders. "Hypoglycaemia in pregnancy : hypoglycaemic clamp studies during and after pregnancy in women with IDDM /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980605bjor.

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7

Wilkerson, Diana Sue. "Perinatal complications as predictors of infantile autism." Virtual Press, 1992. http://liblink.bsu.edu/uhtbin/catkey/833467.

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This study investigated the impact of perinatal complications on the developing child and the relationship of those complications to the development of autism in an individual. The biological mothers of autistic children (N = 183) completed the Maternal Perinatal Scale, a maternal selfreport which surveys complications of pregnancy and medical conditions of the mother. Archival data on normals (N = 209), obtained during previous perinatal investigations, was utilized as a control group.Previous research in this area has been limited, with no definitive conclusions. All previous investigators h

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8

Walker, Kate Frances. "Late pregnancy complications in women of advanced maternal age." Thesis, University of Nottingham, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.718852.

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The age of childbearing is rising in women living in industrialised nations. Advanced maternal age is associated with a small increased risk of term antepartum stillbirth. Labour induction would likely reduce stillbirth, but might also increase Caesarean delivery, already high for older women. The aim of this thesis was to design and conduct a randomised controlled trial of induction of labour at 39 weeks versus expectant management for nulliparous women aged over 35 years. In total 619 women participated and the trial showed that induction of labour has no adverse short-term effects on matern

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9

Syngelaki, Argyro. "Screening for pregnancy complications at 11-13 weeks' gestation." Thesis, Manchester Metropolitan University, 2015. http://e-space.mmu.ac.uk/595938/.

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Background: The current approach to prenatal care, which was established more than 80 years ago, is characterised by a high concentration of visits in the third-trimester of pregnancy which implies that firstly, most complications occur at this late stage of pregnancy and secondly, most adverse outcomes are unpredictable during the first or even the second trimester. Objectives: The objective of this thesis is to provide evidence that most pregnancy complications are predictable as early as 12 weeks’ gestation. The pregnancy complications examined include fetal aneuploidies, fetal structural d

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10

Chaudhry, Shazia Hira. "The Association of Homocysteine with Placenta-Mediated Pregnancy Complications." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39425.

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Background: Preeclampsia, small for gestational age (SGA), placental abruption, and fetal death are pregnancy complications linked to the utero-placental vasculature with serious consequences for maternal and infant well-being. Elevated homocysteine, a marker of cardiovascular disease risk, is postulated to play a role in placenta-mediated complications, but epidemiologic studies have reported inconsistent findings. The two primary objectives of this thesis were to 1: comprehensively investigate the association of homocysteine with placenta-mediated complications and examine modifying effects

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11

Nevin, James. "Pregnancy-associated cervical cancer." Thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/26272.

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12

Linné, Yvonne. "Factors affecting weight development after pregnancy - the SPAWN (Stockholm Pregnancy And Women's Nutrition) study /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-405-4/.

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13

Nilsson, Emma. "Genetic epidemiological studies of adverse pregnancy outcomes and the role of schizophrenia /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-590-9/.

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14

Matte, Susan Marie. "HOW PREGNANT DIABETIC WOMEN VIEW THEIR PREGNANCIES." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/275243.

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15

Chambers, Andrea Suzanne. "Relaxation During Pregnancy to Reduce Stress and Anxiety and Their Associated Complications." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/195435.

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Stress and anxiety during pregnancy predict perinatal complications over the course of pregnancy and labor as well as premature birth and low infant birth weight. The current study examined whether relaxation training provided to women at the beginning of the 2nd trimester could reduce stress and anxiety and assessed the impact of the intervention on perinatal complications, premature delivery, and infant outcomes at birth. Twenty-six moderately anxious pregnant women between 14 and 20 weeks gestation participated in the treatment study. Women completed a baseline laboratory assessment that i

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16

Shub, Alexis. "Periodontal disease and adverse pregnancy outcomes." University of Western Australia. School of Women's and Infants' Health, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0184.

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[Truncated abstract] Periodontal disease is a common and underdiagnosed disease in humans that may have adverse effects on pregnancy outcomes. The aim of this thesis was to investigate the effects of periodontal disease in pregnancy by means of two observational human studies and the development of animal models of fetal and uterine exposure to periodontopathic bacteria and lipopolysaccharide. I performed a prospective study examining the rates of preterm birth, small for gestational age neonates and neonatal inflammation in 277 women who had undergone a detailed antenatal periodontal examinat

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17

Tong, Stephen. "Investigation of novel endocrine markers of early pregnancy and later pregnancy health." Monash University, Dept. of Obstetrics and Gynaecology, 2004. http://arrow.monash.edu.au/hdl/1959.1/9689.

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18

Ives, Angela Denise. "Breast cancer and pregnancy : how does a concurrent or subsequent pregnancy affect breast cancer diagnosis, management and outcomes?" University of Western Australia. School of Surgery, 2010. http://theses.library.uwa.edu.au/adt-WU2010.0038.

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[Truncated abstract] A diagnosis of breast cancer is a life-changing event for any woman. For young women and their families it can be devastating. Women aged less than 45 years make up 20% of new cases of breast cancer diagnosed annually in Australia. With the trend for women to delay pregnancy, young women diagnosed with breast cancer may want at least the option to become pregnant after diagnosis and treatment but little is known about how pregnancy affects breast cancer or how breast cancer affects pregnancy. The aims of this thesis were to investigate how concurrent and subsequent pregna

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19

Porter, Charlene. "Immunological, molecular and proteomic evaluation of pregnancy associated conditions using human placental models." Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=167960.

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Haemolytic Disease of the Foetus and Newborn (HDFN) and Foetal and Neonatal Alloimmune Thrombocytopenia (FNAIT) are the most clinically relevant alloimmune disorders of pregnancy caused by maternal alloimmunisation to paternally derived foetal red blood cell (RhD) and platelet antigens (HPA-1a) respectively. Recombinant Fc-modified antibodies have been designed as inert potential biotherapeutics to compete with maternal alloantibodies and reduce foetal mortality. Fc-modified anti-D (Fog1G1 Δnab) and anti-HPA-1a (B2G1Δnab & B2G1Δnac) have been evaluated for their materno-foetal transport capaci

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20

Hamel, Lois C. "Planning for a Healthier Birth and Beyond: Strategies Women Use to Manage Gestational Diabetes." Fogler Library, University of Maine, 2003. http://www.library.umaine.edu/theses/pdf/HamelLC2003.pdf.

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21

Zetterström, Karin. "Chronic Hypertension and Pregnancy : Epidemiological Aspects on Maternal and Perinatal Complications." Doctoral thesis, Uppsala University, Department of Women's and Children's Health, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7755.

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<p>These studies were undertaken to investigate risks of maternal and perinatal complications in pregnant women with chronic hypertensive disease, and to investigate future risk of preeclampsia in women born small for gestational age (SGA). Population based cohort studies using the Swedish Medical Birth Register from different years were performed.</p><p>The maternal complications mild and severe preeclampsia, gestational diabetes and abruptio placenta were studied in a population of 681 515 women, with a prevalence of 0,5% for chronic hypertension. Risk estimates were adjusted for differences

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22

Zetterström, Karin. "Chronic hypertension and pregnancy : epidemiological aspects on maternal and perinatal complications /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7755.

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23

Aye, Christina. "The influence of pregnancy complications on fetal and neonatal cardiovascular development." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:e3353669-2a87-4e68-9905-a4beb1d7fb9c.

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It is becoming increasingly clear that exposure to pregnancy complications such as hypertensive disorders of pregnancy and premature birth (birth before 37 weeks gestation) have a long term and specific effect on future cardiovascular disease development and risk in the offspring. Those born to a preeclamptic pregnancy have been shown to have double the risk of stroke in adulthood and studies have consistently shown an increase in blood pressure in these individuals. Higher blood pressure has also been observed in those born preterm in addition to specific cardiac modifications in young adulth

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24

Bakun, O. V., and D. Ashish. "THE INFLUENCE OF PYELONEPHRITIS COMPLICATIONS ON COURSE OF PREGNANCY AND LABOR." Thesis, Буковинський державний медичний університет, 2014. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/9600.

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Pyelonephritis - nonspecific, infectious-inflammatory process with primary and primary lesion interstitial tissue walls and renal tubules, with subsequent involvement of glomerular and vascular system. Different pathological conditions, which provoked acute stage of chronical pyelonephritis among pregnant women has been analized. Among: anomalies of kidney development, glomerulonephritis, hypertonic disease, preeclampsia and oth. According retrospective investigation of case history of women of postpartum period which have complicated pyelonephritis of Chernivtsi region has been received such

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25

Myers, Patricia D. "The Association of Maternal Pregnancy Complications and Sudden Infant Death Syndrome." [Tampa, Fla.] : University of South Florida, 2003. http://purl.fcla.edu/fcla/etd/SFE0000068.

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26

Noftall, Alice. "The experience of men whose partners are hospitalized for high-risk pregnancies : a phenomenological study /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0016/MQ55532.pdf.

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27

Yatich, Nelly J. "The effect of malaria and intestinal helminth coinfection on birth outcomes in Ghana." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008r/yatich.pdf.

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28

KAZAMA, SHARON WONG. "THE EFFECTS OF STRESS AND MARITAL INTIMACY ON PREGNANCY AND BIRTH COMPLICATIONS." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184150.

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The present prospective longitudinal investigation examined the relationship of life event stress and marital intimacy to pregnancy and birth complications (N = 65). As expected, marital intimacy had a significant buffering effect on stress, but had no relationship with pregnancy and birth complications. In addition, stress levels were not related to pregnancy outcome. Social desirability and conflict resolution on the intimacy measure, as well as ethnicity were significantly related to pregnancy and birth complications. Particular attention is focused on social desirability and its implicatio

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29

Gebremedhin, Amanuel Tesfay. "Effects of interpregnancy interval on pregnancy complications in a high-income country." Thesis, Curtin University, 2021. http://hdl.handle.net/20.500.11937/85548.

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Using a high-quality, population-based cohort spanning over 35 years in WA, we found insufficient evidence to suggest that short intervals increase the risk of hypertensive disorders of pregnancy (HDPs) and gestational diabetes. However, long intervals (>24 months) were associated with an increased risk of HDPs. Findings from this thesis suggest that optimal intervals vary by maternal age and previous pregnancy complications at birth prior to the interval and challenge the applicability of the current birth spacing recommendations, including WHO, to high-income settings such as Australia.

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30

Okong, Pius. "Maternal morbidity in Uganda : studies on life-threatening pregnancy complications in low-income settings /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-127-X/.

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31

Öhman, Inger. "Newer antiepileptic drugs in women of child-bearing age : pharmacokinetic studies during pregnancy, breastfeeding, and contraception /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7357-046-X/.

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32

Laresgoiti, Servitje Estibalitz. "Effect of Stress, Emotional Lability and Depression on the Development of Pregnancy Complications." Thesis, Walden University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3591710.

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<p> Chronic stress and other emotional factors may have relevant impacts on pregnancy outcomes because they are related to neuroendocrine changes that lead to alterations in immunomodulation during pregnancy. In this quantitative prospective cross-sectional study, the relationship of emotional lability, depression, and stress during pregnancy and the development of preterm labor, preeclampsia, placental abruption, and low birth weight for gestational age babies was examined. Additionally, social support scores were compared to levels of stress/anxiety, depression, and emotional lability in pre

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33

Laresgoiti, Servitje Servitje Estibalitz. "Effect of Stress, Emotional Lability and Depression on the Development of Pregnancy Complications." ScholarWorks, 2011. https://scholarworks.waldenu.edu/dissertations/1074.

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Chronic stress and other emotional factors may have relevant impacts on pregnancy outcomes because they are related to neuroendocrine changes that lead to alterations in immunomodulation during pregnancy. In this quantitative prospective cross-sectional study, the relationship of emotional lability, depression, and stress during pregnancy and the development of preterm labor, preeclampsia, placental abruption, and low birth weight for gestational age babies was examined. Additionally, social support scores were compared to levels of stress/anxiety, depression, and emotional lability in pregnan

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34

Didrickson, Susanna. "Facing Uncertainty on Two Fronts: The Experience of Being Pregnant While One's Husband is Deployed." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/578608.

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This qualitative descriptive study investigated the unique and specific impact of being pregnant while one's husband was deployed to a combat zone. Three specific aims were used to address the study objectives 1) Describe the experience of being pregnant while one's husband is deployed 2) Describe the women's experiences with health-care providers 3) Describe the types of support women sought or had access to during pregnancy. Participants were 16 women who had been pregnant while their husbands were deployed for greater than 30 days from 2004-2014, with no prior personal history of being depl

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35

Hill, S. Kristian. "Maternal perinatal events as predictors of sensory-motor functioning in normal children." Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1117100.

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The relationship between perinatal complications and sensory-motor functions was examined. Information from the Maternal Perinatal Scale (MPS) was used to predict factor scores of the Dean Sensory-Motor Battery (DSMB). Participants were 187 normal nonreferred children who were administered the DSMB while their mothers completed the MPS. Using MPS items as predictors, separate stepwise regression analyses for each DSMB factor found that 11 - 16% of variance could be accounted for in sensory-motor performance. At least three MPS items significantly contributed to the prediction of each DSMB fact

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36

Challis, Kenneth. "Monitoring pregnancy for improved perinatal outcome in Mozambique /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-406-2/.

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37

Vääräsmäki, M. (Marja). "Care and outcome of Finnish diabetic pregnancy." Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:951426469X.

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Abstract The aim of this study was to evaluate the treatment, course and outcome of pregnancy in Finland using two cohorts of diabetic women. The clinical cohort consisted of data from all 210 women with Type 1 diabetes and their 296 pregnancies managed between 1986 and 1995 in the two northernmost provinces of Finland. The register-based study population included all 1442 mothers with a singleton birth who had insulin treatment during pregnancy in 1991-1995 according to the Medical Birth Register. Of these mothers, 954 (66%) had pre-existing diabetes. Insulin-treated diabetes complicated

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38

Toivo, Aini-Kaarin. "Perceptions and experiences of pregnant women towards HIV voluntary antenatal counselling and testing in Oshakati Hospital, Namibia." Thesis, University of the Western Cape, 2005. http://etd.uwc.ac.za/index.php?module=etd&amp.

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This study focused on perceptions and experiences of pregnant women who opted in against those who opted out of voluntary antenatal HIV counseling and testing. The pregnant women's perceptions and experiences were assessed in order to gain insight into their views towards voluntary antenatal counseling and testing.

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39

Fritz, Kathleen Gary. "Development of a urinary metabolic ratio that reflects systemic theophylline elimination during pregnancy." Scholarly Commons, 1993. https://scholarlycommons.pacific.edu/uop_etds/2245.

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A number of studies have investigated the natural history of asthma in pregnancy. Most of the data suggests that the course of asthma for a given patient is unpredictable. Turner, et al.7 summarize the data from all of the English-language literature of studies on the effect of pregnancy on astha. Of 1054 cases examined, 49% of the asthma conditions remained unchanged, 22% got worst and 29% became better.7 Theophylline has been used safely during pregnancy. A review of the literature by O'Brien, showed that no teratogenic effects were associated with the use of theophylline in 117 cases and am

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40

Mathai, Elizabeth. "Genital and urinary tract infections in pregnancy in southern India : diagnosis, management and impact on perinatal outcome /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-129-6/.

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41

林勇行 and Yung-hang Lam. "Sonographic features of fetuses with homozygous [alpha]-thalassaemia-1during early pregnancy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31981744.

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42

Edwards, Lisa J. "Maternal undernutrition and fetal blood pressure and the hypothalamo-pituitary adrenal axis in the late gestation fetal sheep." Title page, table of contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phe2654.pdf.

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Includes bibliographical references (leaves 228-257). Aims to determine the impact of maternal undernutrition during late gestation and during the periconceptional and gestational periods on fetal growth, fetal blood pressure and the fetal hypothalamo-pituitary adrenal axis in the sheep.

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43

Ojodun, Olumide. "The prevalence of hypertensive complications of pregnancy in Dora Nginza Hospital, Port Elizabeth, Eastern Cape." Thesis, Stellenbosch : Stellenbosch University, 2010. http://hdl.handle.net/10019.1/20451.

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Research report (MMed) -- Stellenbosch University, 2010.<br>Bibliography<br>ENGLISH ABSTRACT: BACKGROUND: Hypertension and its complications is responsible for a significant proportion of maternal and neonatal morbidity and mortality worldwide. In Dora Nginza Hospital, clinical experience has shown that hypertension and its complications are common but despite this assumption, the overall prevalence of complications, social and demographic characteristics and various forms of presentations of hypertension in pregnancy is still largely unknown. OBJECTIVES: To determine the prevalence of compl

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44

Poles, A. "Glycoprotein estimation and analysis of genes associated with inherited platelet disorders and complications of pregnancy." Thesis, University of the West of England, Bristol, 2013. http://eprints.uwe.ac.uk/22243/.

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The archetypical inherited platelet (PLT) disorders are Glanzmann’s Thrombasthenia (GT) and Bernard Soulier Syndrome (BSS) and both are autosomal recessive disorders. GT results from mutations in the ITGB3 and/or ITGA2B genes that encode the GPIIb/IIIa complex, while BSS results from mutations in the genes (GPIba, GPIbb and GPIX) that encode the GPIb/IX/V complex. GT and BSS patients have a mild bleeding tendency which is in contrast with patients with another inherited PLT disorder known as congenital amegakaryocytic thrombocytopenia (CAMT). CAMT is associated with mutations in the MPL gene t

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45

Chalana, Vikram. "Deformable models for segmentation of medical ultrasound images /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/8025.

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46

Rogal, Shari. "The Effects of Posttraumatic Stress Disorder on Pregnancy Outcomes." Yale University, 2006. http://ymtdl.med.yale.edu/theses/available/etd-06282006-141433/.

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The purpose of this study was to determine the effect of posttraumatic stress disorder (PTSD), diagnosed prospectively during pregnancy, on the occurrence of low birthweight (<2500 grams) and preterm delivery (<37 weeks gestational age). A cohort of 1362 women was recruited from prenatal care visits and screened for depression, panic disorder, posttraumatic stress disorder, and substance use. Current episodes of PTSD were assessed using the MINI International Neuropsychiatric Interview. Pregnancy outcomes were abstracted from hospital records after delivery, and the data were analyzed using lo

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47

Spadafore, Lori. "Relationship between perinatal complications and attention deficit hyperactivity disorder and other behavioral characteristics." Virtual Press, 1997. http://liblink.bsu.edu/uhtbin/catkey/1115716.

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The present study was undertaken to determine the relationship between perinatal complications and subsequent development of Attention Deficit Hyperactivity Disorder (ADHD) and other behavioral characteristics. The biological mothers of 74 children diagnosed with ADHD and 77 children displaying no characteristics of the disorder completed the Maternal Perinatal Scale (MPS), the Behavior Assessment System for Children-Parent Rating Scales (BASC-PRS), and a demographic survey. In addition, the biological mothers of 120 children with no characteristics of ADHD or any other behavior disorders comp

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48

Janssen, Anna. "Investigating a role for imprinted genes in pregnancy complications and the possible influence of maternal lifestyle." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/80617/.

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Imprinted genes, displaying monoallelic parent of origin specific expression, are known to regulate fetal growth and placental development. Work in animal models also suggests that imprinted genes regulate placental hormone signalling to the mother, which is required for induction of maternal adaptation to pregnancy. Aberrant placental imprinted gene expression may therefore have a causative role in pregnancies characterised by abnormal fetal growth and/or inadequate maternal adaptation to pregnancy. Given these important functions, identifying environmental stimuli responsible for perturbed i

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49

Reep, Daniel T. "Placental Eicosanoids and Sphingolipids in Preeclampsia." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5553.

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Placental dysfunction is implicated in the pathogenesis of preeclampsia. Chemical signals between the placenta and maternal circulation are a suspect cause of endothelial dysfunction and maternal hypertension. This study examined select lipid mediators of inflammation produced by the placenta. Patients were recruited from Virginia Commonwealth University’s pregnancy clinics and placentas were collected at delivery. Forty-eight-hour explant cultures of villous placental tissue were used to model lipid production. Electrospray ionization mass spectrometry was used to quantify concentrations of f

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50

Abdel, Azim Hatem Hamdy. "Breast cancer in young women: impact of pregnancy on biology and outcome." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209357.

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In this work, we found that proliferation-related prognostic gene signatures could aid treatment decision-making independent of age. This is clinically relevant for the younger breast cancer population given the potential long-term side effects of adjuvant systemic chemotherapy and hence the need to identify patients who are less likely to benefit adjuvant chemotherapy. In addition, it was clear that young age at diagnosis adds extra biological complexity, which is independent of differences in breast cancer subtype distribution. This includes enrichment with known breast cancer targets like R

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